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[PMID]:29381775
[Au] Autor:Sundaramoorthy J; Park GT; Mukaiyama K; Tsukamoto C; Chang JH; Lee JD; Kim JH; Seo HS; Song JT
[Ad] Endereço:School of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.
[Ti] Título:Molecular elucidation of a new allelic variation at the Sg-5 gene associated with the absence of group A saponins in wild soybean.
[So] Source:PLoS One;13(1):e0192150, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In soybean, triterpenoid saponin is one of the major secondary metabolites and is further classified into group A and DDMP saponins. Although they have known health benefits for humans and animals, acetylation of group A saponins causes bitterness and gives an astringent taste to soy products. Therefore, several studies are being conducted to eliminate acetylated group A saponins. Previous studies have isolated and characterized the Sg-5 (Glyma.15g243300) gene, which encodes the cytochrome P450 72A69 enzyme and is responsible for soyasapogenol A biosynthesis. In this study, we elucidated the molecular identity of a novel mutant of Glycine soja, 'CWS5095'. Phenotypic analysis using TLC and LC-PDA/MS/MS showed that the mutant 'CWS5095' did not produce any group A saponins. Segregation analysis showed that the absence of group A saponins is controlled by a single recessive allele. The locus was mapped on chromosome 15 (4.3 Mb) between Affx-89193969 and Affx-89134397 where the previously identified Glyma.15g243300 gene is positioned. Sequence analysis of the coding region for the Glyma.15g243300 gene revealed the presence of four SNPs in 'CWS5095' compared to the control lines. One of these four SNPs (G1127A) leads to the amino acid change Arg376Lys in the EXXR motif, which is invariably conserved among the CYP450 superfamily proteins. Co-segregation analysis showed that the missense mutation (Arg376Lys) was tightly linked with the absence of group A saponins in 'CWS5095'. Even though Arg and Lys have similar chemical features, the 3D modelled protein structure indicates that the replacement of Arg with Lys may cause a loss-of-function of the Sg-5 protein by inhibiting the stable binding of a heme cofactor to the CYP72A69 apoenzyme.
[Mh] Termos MeSH primário: Alelos
Genes de Plantas
Saponinas/genética
Feijão de Soja/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Saponins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0192150


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[PMID]:29329092
[Au] Autor:Tian Z; Pang H; Zhang Q; Du S; Lu Y; Zhang L; Bai J; Li P; Li D; Zhao M; Chen X
[Ad] Endereço:School of Chinese Materia Medica, Beijing University of Chinese Medicine, 6#, WangjingZhonghuanNanlu, Chaoyang District, Beijing 100102, China; School of Pharmaceutical Science, Tsinghua University, Shuangqinglu, Beijing, China.
[Ti] Título:Effect of aspirin on the pharmacokinetics and absorption of panax notoginseng saponins.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1074-1075:25-33, 2018 Feb 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Panax notoginseng saponins, a traditional Chinese medicine extraction, and aspirin are both widely used to treat cerebral infarction in China. Good results in clinical practice have been achieved, when Panax notoginseng saponins was taken together with aspirin. METHODS: To investigate the interaction of the two drugs in vivo, the concentration of notoginsenoside R , ginsenoside Rg , Rb , Re and Rd. in blood were simultaneously measured by UPLC/MS/MS. Sample preparation was carried out by the protein precipitation technique with an internal standard saikosaponin A standard. The separation of six components was achieved by using an ACQUITY UPLC ®BEH C18 column (1.7µm 2.1×100mm) by gradient elution using water (containing 0.2% formic acid) and acetonitrile (containing 0.2% formic acid) as the mobile phase at a flow rate of 0.2mL/min. The pharmacokinetic parameters were determined using non-compartmental analysis. The transport of notoginsenoside R , ginsenoside Rg , Rb , Re and Rd. in MDCK -MDR1 cell monolayer was also used to verify the conclusion of pharmacokinetic drug-drug interaction and study the mechanism of drug interaction. RESULTS: The concentrations of the five components increased in a certain extent when the two drugs administered together in rats. The values of apparent permeability coefficients were significantly increased when the two drugs were used together. Aspirin and salicylic acid could destroy the tight junction protein and open the intercellular space to increase the absorption of Panax notoginseng saponins. CONCLUSION: Pharmacokinetic drug-drug interaction in vivo existed between Panax notoginseng saponins and aspirin. The drug-drug interaction mainly occurred in the process of absorption.
[Mh] Termos MeSH primário: Aspirina/farmacocinética
Medicamentos de Ervas Chinesas/farmacocinética
Panax notoginseng/química
Saponinas/sangue
Saponinas/farmacocinética
[Mh] Termos MeSH secundário: Animais
Aspirina/farmacologia
Membrana Celular/efeitos dos fármacos
Cães
Medicamentos de Ervas Chinesas/farmacologia
Interações Ervas-Drogas
Limite de Detecção
Modelos Lineares
Células Madin Darby de Rim Canino
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Saponinas/química
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Saponins); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE


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[PMID]:27771848
[Au] Autor:Zhang GB; Ren SS; Wang BY; Tian LQ; Bing FH
[Ad] Endereço:Pharmacy College, He'nan University of Traditional Chinese Medicine, Zhengzhou, 450046, China.
[Ti] Título:Hypouricemic effect of flaccidoside II in rodents.
[So] Source:J Nat Med;71(1):329-333, 2017 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:To investigate the effect of flaccidoside II on the serum uric acid levels in hyperuricemic rodents. Both mice and rats were injected intraperitoneally with potassium oxonate to induce hyperuricemia. Different dosages of flaccidoside II were orally administrated to hyperuricemic and normal rodents for 7 days, respectively. Liver xanthine oxidase (XOD) activities in hyperuricemic mice were determined using the colorimetric method. Acute toxicity of flaccidoside II was also evaluated in mice. Allopurinol, as a positive control, was administered under the same treatment scheme. The results showed that flaccidoside II (32, 16 and 8 mg/kg) could significantly lower serum uric acid levels in hyperuricemic mice. Flaccidoside II (24, 12 and 6 mg/kg) could also markedly lower serum uric acid levels in hyperuricemic rats. However, unlike allopurinol, oral administration of flaccidoside II did not produce any observable hypouricemic effect in normal animals. Flaccidoside II at the dose of 32 mg/kg significantly suppressed XOD activities in the liver of hyperuricemic mice, while at doses of 16 and 8 mg/kg flaccidoside II did not show a significant effect on XOD activities. In addition, flaccidoside II (300 mg/kg) has no or less toxicity than allopurinol in mice. These findings demonstrate that flaccidoside II exhibits anti-hyperuricemic activity in hyperuricemic animals.
[Mh] Termos MeSH primário: Hiperuricemia/induzido quimicamente
Saponinas/efeitos adversos
Ácido Úrico/metabolismo
[Mh] Termos MeSH secundário: Animais
Masculino
Camundongos
Ratos
Ratos Sprague-Dawley
Saponinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-O-rhamnopyranosyl-1-2-xylopyranosyl oleanolic acid 28-O-rhamnopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl ester); 0 (Saponins); 268B43MJ25 (Uric Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-1056-3


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[PMID]:28659043
[Au] Autor:Liu X; Zhang J; Guo K; Jia A; Zhang M; Shi Y; Liu C; Xiao L; Sun Z
[Ad] Endereço:a Key Laboratory for Biosensors of Shandong Province , Biology Institute of Shandong Academy of Sciences , Jinan , China.
[Ti] Título:Three new oleanane-type triterpenoid saponins from the seeds of Celosia cristata L.
[So] Source:Nat Prod Res;32(2):167-174, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the 1-butanol soluble fraction of 60% ethanol extract of the seeds of Celosia cristata L. led to the identification of three new oleanane-type triterpenoid saponins. Using D and D NMR experiment methods, ESI-MS analysis and acid hydrolysis, their structures were identified as 3-O-[ß-D-xylopyranosyl-(1 â†’ 3)-ß-D-glucuronopyranosyl]-2ß-hydroxy-oleanolic acid-28-O-ß-D-glucopyranoside (1), 3-O-[ß-D-xylopyranosyl-(1 â†’ 3)-ß-D-glucuronopyranosyl]-2ß, 23-dihydroxy-oleanolic acid-28-O-ß-D-glucopyranoside (2) and 3-O-[ß-D-glucopyranosyl-(1 â†’ 4)-ß-D-glucopyranosyl]-2-hydroxyl-medicagenic acid-28-O-ß-D-glucopyranosyide (3), respectively.
[Mh] Termos MeSH primário: Celosia/química
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/isolamento & purificação
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Configuração de Carboidratos
Sequência de Carboidratos
Hidrólise
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Ácido Oleanólico/química
Saponinas/química
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); 0 (oleanane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1343317


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[PMID]:29402262
[Au] Autor:Liu MW; Wei R; Su MX; Li H; Fang TW; Zhang W
[Ad] Endereço:Department of Emergency, the First Hospital Affiliated To Kunming Medical University, 295 Xichang Road, Wu Hua District, Kunming, 650032, China. Lmw2004210@163.com.
[Ti] Título:Effects of Panax notoginseng saponins on severe acute pancreatitis through the regulation of mTOR/Akt and caspase-3 signaling pathway by upregulating miR-181b expression in rats.
[So] Source:BMC Complement Altern Med;18(1):51, 2018 Feb 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In China, Panax notoginseng has been used to treat oxidative stress-related diseases for a long time. Panax notoginseng saponins is an extract from Panax notoginseng Ledeb. Its therapeutic potential is related to antioxidant activity, but related mechanisms are still unclear. The study aims to assess the protection effects of Panax notoginseng saponins in the taurocholate-induced rat model of acute pancreatitis (AP) and explore underlying mechanisms. METHODS: A rat model of severe acute pancreatitis (SAP) was established in rats induced with taurocholate. Panax notoginseng saponins was firstly administered in the treatment group via intravenous injection. After 2 h, taurocholate administration was performed. After 24 h, the expression levels of miR-181b, Beclin1, LC3-II, Akt and mTOR from pancreas tissues were measured by Western Blotting and RT-PCR. Then the expression levels of Caspase-3 and Blc-2 were determined by immunohistochemistry. Apoptosis was assessed by the TUNEL assay. Amylase and lipase in serum were determined by ELISA and pancreatic water contents in pancreatic tissue were measured. After eosin and hematoxylin staining, the histologic analysis was performed. RESULTS: After SAP induction by taurocholate and the treatment with Panax notoginseng saponins for 24 h, we detected the up-regulated miR-181b, the reduced Bcl-2 expression, the increased activity of mTOR/Akt, the blocked Beclin1 and LC3-II expressions, and the enhanced Caspase-3 expression. Serum lipase and amylase levels were significantly decreased in the treatment group of Panax notoginseng saponins compared to the control group. Histological analysis results verified the attenuation effects of Panax notoginseng saponins on taurocholate-induced pancreas injury, apoptosis, and autophagy. CONCLUSION: By up-regulating the miR-181b expression level, Panax notoginseng saponins significantly reduced taurocholate-induced pancreas injury and autophagy and increased apoptosis. The significant protection effects of Panax notoginseng saponins suggested its potential in treating taurocholate induced-acute pancreatitis.
[Mh] Termos MeSH primário: Caspase 3/metabolismo
MicroRNAs/metabolismo
Panax notoginseng
Pancreatite/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Saponinas/farmacologia
Serina-Treonina Quinases TOR/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Modelos Animais de Doenças
Masculino
MicroRNAs/genética
Pâncreas/efeitos dos fármacos
Pâncreas/patologia
Pancreatite/patologia
Extratos Vegetais
Ratos
Ratos Sprague-Dawley
Transdução de Sinais/efeitos dos fármacos
Ácido Taurocólico/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN181 microRNA, rat); 0 (MicroRNAs); 0 (Plant Extracts); 0 (Saponins); 5E090O0G3Z (Taurocholic Acid); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.1 (mTOR protein, rat); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2118-8


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[PMID]:28743418
[Au] Autor:Kwon M; Ji HK; Goo SH; Nam SJ; Kang YJ; Lee E; Liu KH; Choi MK; Song IS
[Ad] Endereço:Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea; College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea.
[Ti] Título:Involvement of intestinal efflux and metabolic instability in the pharmacokinetics of platycodin D in rats.
[So] Source:Drug Metab Pharmacokinet;32(5):248-254, 2017 Oct.
[Is] ISSN:1880-0920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We aimed to investigate the underlying mechanisms for low bioavailability of Platycodin D (PD) in rats. The bioavailability of PD was 1.89% with different half-lives depending on the administration route (2.14 ± 0.18 h for intravenous injection vs 5.42 ± 1.9 h for oral administration). The mean absorption time was 6.3 h calculated from the mean residence time of both administration routes. Consistent with these parameters, rat intestinal permeability using 3 different intestinal segments showed a low but greatest permeability in lower ileum (0.05 × 10 cm/s in jejunum and upper ileum vs 0.13 × 10 cm/s in lower ileum). The involvement of efflux system, probably Mrps, in upper ileum, could be explained from the efflux ratio of 6.4 and reduced efflux ratio by an Mrp inhibitor, MK571. The recovery of unchanged PD after the intravenous and oral administration was 50% and 5.2%, respectively, suggesting the contribution of gastrointestinal metabolism. In the gastrointestinal content, 4 metabolites of PD were identified: acetylated PD (m/z 1265.6), deglucose PD (m/z 1061.5), deapiose PD (m/z 1091.5), and deapiose-dexylose-derhamnose PD (m/z 813.4). In conclusion, the intestinal first-pass effect such as the presence of efflux functions in the upper ileum, limited but steady intestinal permeability, and gastrointestinal metabolism could explain the low bioavailability and prolonged absorption time of orally administered PD.
[Mh] Termos MeSH primário: Intestinos/metabolismo
Saponinas/farmacocinética
Triterpenos/farmacocinética
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Injeções Intravenosas
Masculino
Ratos
Ratos Sprague-Dawley
Saponinas/administração & dosagem
Triterpenos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); 0 (Triterpenes); CWJ06TA2GI (platycodin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:29253815
[Au] Autor:Sabela MI; Makhanya T; Kanchi S; Shahbaaz M; Idress D; Bisetty K
[Ad] Endereço:Department of Chemistry, Durban University of Technology, P.O Box 1334, Durban 4000, South Africa. Electronic address: myalos@dut.ac.za.
[Ti] Título:One-pot biosynthesis of silver nanoparticles using Iboza Riparia and Ilex Mitis for cytotoxicity on human embryonic kidney cells.
[So] Source:J Photochem Photobiol B;178:560-567, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plant extracts continue gaining significant prominence in green synthesis of silver nanoparticles (AgNPs), due to their potential applications in nano-medicine and material engineering. This work reports on green synthesis of silver nanoparticles (AgNPs) from aqueous extracts of Iboza Riparia leaf and Ilex Mitis root bark with diterpenes (DTPs) and saponins (SPNs) as major components. After TEM, DLS, TGA/DSC, ATR, XRD and UV-Vis characterization, the relevant cytotoxicity studies were conducted with the MTT assay on human embryonic kidney cells (HEK293T) followed by antioxidant activity with ABTS. Overall, the AgNPs-DTPs (156nm) were found to be less toxic with 49.7% cell viability, while AgNPs-SPNs (50nm) and AgNPs-PVA (44nm) had cell viability of 40.8 and 28.0% respectively at 400µM. Based on the cytotoxicity and antioxidant activity, it is fair to report that these plant extracts have potential reducing and capping agents as they retain chemical properties on the surface of the nanoparticles.
[Mh] Termos MeSH primário: Ilex/química
Nanopartículas Metálicas/química
Prata/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Varredura Diferencial de Calorimetria
Sobrevivência Celular/efeitos dos fármacos
Diterpenos/química
Diterpenos/isolamento & purificação
Química Verde
Células HEK293
Seres Humanos
Ilex/metabolismo
Nanopartículas Metálicas/toxicidade
Tamanho da Partícula
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Raízes de Plantas/química
Raízes de Plantas/metabolismo
Saponinas/química
Saponinas/isolamento & purificação
Espectrofotometria Ultravioleta
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Diterpenes); 0 (Plant Extracts); 0 (Saponins); 3M4G523W1G (Silver)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29260546
[Au] Autor:Zhang YZ; Zhang JW; Wang CZ; Zhou LD; Zhang QH; Yuan CS
[Ad] Endereço:School of Chemistry and Chemical Engineering, Chongqing University , Chongqing 400044, China.
[Ti] Título:Polydopamine-Coated Magnetic Molecularly Imprinted Polymers with Fragment Template for Identification of Pulsatilla Saponin Metabolites in Rat Feces with UPLC-Q-TOF-MS.
[So] Source:J Agric Food Chem;66(3):653-660, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this work, a modified pretreatment method using magnetic molecularly imprinted polymers (MMIPs) was successfully applied to study the metabolites of an important botanical with ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). The MMIPs for glucoside-specific adsorption was used to identify metabolites of Pulsatilla chinensis in rat feces. Polymers were prepared by using Fe O nanoparticles as the supporting matrix, d-glucose as fragment template, and dopamine as the functional monomer and cross-linker. Results showed that MMIPs exhibited excellent extraction performance, large adsorption capacity (5.65 mg/g), fast kinetics (60 min), and magnetic separation. Furthermore, the MMIPs coupled with UPLC-Q-TOF-MS were successfully utilized for the identification of 17 compounds including 15 metabolites from the Pulsatilla saponin metabolic pool. This study provides a reliable protocol for the separation and identification of saponin metabolites in a complex biological sample, including those from herbal medicines.
[Mh] Termos MeSH primário: Fezes/química
Nanopartículas de Magnetita/química
Polímeros/química
Pulsatilla/metabolismo
Saponinas/química
Saponinas/isolamento & purificação
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Indóis/química
Magnetismo
Espectrometria de Massas
Impressão Molecular
Polímeros/síntese química
Pulsatilla/química
Ratos
Saponinas/metabolismo
Extração em Fase Sólida/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Magnetite Nanoparticles); 0 (Polymers); 0 (Saponins); 0 (polydopamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05747


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[PMID]:28463530
[Au] Autor:Shi L; Tan DH; Yan TC; Jiang DH; Hou MX
[Ad] Endereço:a College of Food Science, Shenyang Agricultural University , Shenyang 110866 , China.
[Ti] Título:Cytotoxic triterpenes from the acid hydrolyzate of Gynostemma pentaphyllum saponins.
[So] Source:J Asian Nat Prod Res;20(2):182-187, 2018 Feb.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3ß,20,21ß,23ß,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3ß-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Gynostemma/química
Saponinas/isolamento & purificação
Saponinas/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Saponinas/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Saponins); 0 (Triterpenes); 545-22-2 (dammarane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1322070


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[PMID]:29183124
[Au] Autor:Lan X; Deng K; Zhao J; Chen Y; Xin X; Liu Y; Khan IA; Yang S; Wang T; Xu Q
[Ad] Endereço:Department of Biotechnology, School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China , Chengdu 610054, China.
[Ti] Título:New Triterpenoid Saponins from Green Vegetable Soya Beans and Their Anti-Inflammatory Activities.
[So] Source:J Agric Food Chem;65(50):11065-11072, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten compounds were isolated and identified from green vegetable soya beans, of which five are new triterpenoid saponins (1-5) and five are known compounds (6-10). The chemical structures of the five triterpenoid saponins (1-5) were elucidated to be 3ß,24-dihydroxy-22ß,30-epoxy-30-oxoolean-12-en 3-O-α-l-rhamnopyranosyl-(1 → 2)-ß-d-xylopyranosyl-(1 → 2)-ß-d-glucuronopyranoside, 1; 3ß,24-dihydroxy-22ß,30-epoxy-30-oxoolean-12-en 3-O-α-l-rhamnopyranosyl-(1 → 2)-ß-d-(3″-O-formyl)-galactopyranosyl-(1 → 2)-ß-d-glucuronopyranoside, 2; 22-keto-3ß,24-dihydroxy oleanane-12-ene 3-O-α-l-rhamnopyranosyl-(1 → 2)-ß-d-(3″-O-formyl)-galactopyranosyl-(1 → 2)-ß-d-glucuronopyranoside, 3; 3ß,22ß,24-trihydroxy oxyolean-18(19)-ene-29-acid 3-O-α-l-rhamnopyranosyl-(1 → 2)-ß-d-galactopyranosyl-(1 → 2)-ß-d-glucuronopyranoside, 4; and punicanolic acid 3-O-α-l-rhamnopyranosyl-(1 → 2)-ß-d-galactopyranosyl-(1 → 2)-ß-d-glucuronopyranoside, 5 from the spectroscopic data (IR, GTC/FID, HR-ESI-MS, and 1D and 2D NMR). The nitric oxide release inhibitions of compounds 1-10 in LPS-stimulated RAW264.7 cells were evaluated, and the data suggested that compounds 1, 2, and 5 might possess moderate anti-inflammatory activities, with IC values of 18.8, 16.1, and 13.2 µM, respectively.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Extratos Vegetais/química
Saponinas/química
Feijão de Soja/química
Triterpenos/química
Verduras/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Camundongos
Estrutura Molecular
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Células RAW 264.7
Saponinas/isolamento & purificação
Saponinas/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04134



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