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[PMID]:28450244
[Au] Autor:El-Naggar AWM; Senna MM; Mostafa TA; Helal RH
[Ad] Endereço:Radiation Chemistry Department, National Center for Radiation Research and Technology, Nasr City, Atomic Energy Authority, Cairo, Egypt. Electronic address: ab_nagga@yahoo.com.
[Ti] Título:Radiation synthesis and drug delivery properties of interpenetrating networks (IPNs) based on poly(vinyl alcohol)/ methylcellulose blend hydrogels.
[So] Source:Int J Biol Macromol;102:1045-1051, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gamma radiation was used to prepare blend hydrogels from poly(vinyl alcohol) (PVA) and low ratios of methylcellulose (MC). The structure-property behavior was characterized by IR spectroscopy, gel fraction, differential scanning calorimetry (DSC) and swelling at room temperature and different pH values. The PVA/MC hydrogels were used as a carrier for doxycycline hyclate (DOX-h) drug. The results showed that the gel fraction of PVA/MC hydrogels decreased greatly with increasing the ratio of MC in the initial feeding solution. The PVA/MC hydrogels displayed pH-sensitive swelling character. The drug uptake-release study indicated that PVA/MC hydrogels possessed controlled release behavior and that the release process depends on pH. In this respect, the release of DOX-h drug was significant in alkaline medium.
[Mh] Termos MeSH primário: Portadores de Fármacos/química
Portadores de Fármacos/síntese química
Hidrogéis/química
Hidrogéis/síntese química
Metilcelulose/química
Álcool de Polivinil/química
[Mh] Termos MeSH secundário: Técnicas de Química Sintética
Doxiciclina/química
Liberação Controlada de Fármacos
Raios gama
Concentração de Íons de Hidrogênio
Radioquímica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Hydrogels); 9002-89-5 (Polyvinyl Alcohol); 9004-67-5 (Methylcellulose); N12000U13O (Doxycycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28453954
[Au] Autor:Pakulska MM; Tator CH; Shoichet MS
[Ad] Endereço:Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 3E5, Canada; Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
[Ti] Título:Local delivery of chondroitinase ABC with or without stromal cell-derived factor 1α promotes functional repair in the injured rat spinal cord.
[So] Source:Biomaterials;134:13-21, 2017 Jul.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Traumatic spinal cord injury (SCI) is a devastating event for which functional recovery remains elusive. Due to the complex nature of SCI pathology, a combination treatment strategy will likely be required for success. We hypothesized that tissue and functional repair would be achieved in a rat model of impact-compression SCI by combining degradation of the glial scar, using chondroitinase ABC (ChABC), with recruitment of endogenous neural precursor cells (NPCs), using stromal cell-derived factor 1α (SDF). To test this hypothesis, we designed a crosslinked methylcellulose hydrogel (XMC) for minimally invasive, localized, and sustained intrathecal drug delivery. ChABC was released from XMC using protein-peptide affinity interactions while SDF was delivered by electrostatic affinity interactions from polymeric nanoparticles embedded in XMC. Rats with SCI were treated acutely with a combination of SDF and ChABC, SDF alone, ChABC alone, or vehicle alone, and compared to injury only. Treatment with ChABC, both alone and in combination with SDF, resulted in faster and more sustained behavioural improvement over time than other groups. The significantly reduced chondroitin sulfate proteoglycan levels and greater distribution of NPCs throughout the spinal cord tissue with ChABC delivery, both alone and in combination with SDF, may explain the improved locomotor function. Treatment with SDF alone had no apparent effect on NPC number or distribution nor synergistic effect with ChABC delivery. Thus, in this model of SCI, tissue and functional repair is attributed to ChABC.
[Mh] Termos MeSH primário: Quimiocina CXCL12/química
Condroitina ABC Liase/metabolismo
Traumatismos da Medula Espinal/metabolismo
[Mh] Termos MeSH secundário: Animais
Quimiocina CXCL12/metabolismo
Quimiocina CXCL12/uso terapêutico
Condroitina ABC Liase/química
Proteoglicanas de Sulfatos de Condroitina/química
Ensaio de Imunoadsorção Enzimática
Feminino
Hidrogel de Polietilenoglicol-Dimetacrilato/química
Imuno-Histoquímica
Metilcelulose/química
Células-Tronco Neurais/citologia
Células-Tronco Neurais/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Traumatismos da Medula Espinal/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokine CXCL12); 0 (Chondroitin Sulfate Proteoglycans); 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 9004-67-5 (Methylcellulose); EC 4.2.2.20 (Chondroitin ABC Lyase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  3 / 4098 MEDLINE  
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[PMID]:29211290
[Au] Autor:Lee BN; Chun SJ; Chang HS; Hwang YC; Hwang IN; Oh WM
[Ad] Endereço:Chonnam National University, School of Dentistry, Dental Science Research Institute, Department of Conservative Dentistry, Gwangju, Korea.
[Ti] Título:Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulose and calcium chloride.
[So] Source:J Appl Oral Sci;25(6):680-688, 2017 Nov-Dec.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. This study assessed the influence of MC as an anti-washout ingredient and CaCl2 as a setting time accelerator on the physical and biological properties of MTA. MATERIAL AND METHODS: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl2; Group 3: 2% MC/CaCl2. Compressive strength, pH, flowability and cell viability were tested. The gene expression of bone sialoprotein (BSP) was detected by RT-PCR and real- time PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. RESULTS: Compressive strength, pH, and cell viability of MTA mixed with MC/CaCl2 were not significantly different compared to the control group. The flowability of MTA with MC/CaCI2 has decreased significantly when compared to the control (p<.05). The mRNA level of BSP has increased significantly in MTA with MC/CaCl2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl2 compared to the control (p<.05). CONCLUSIONS: MC decreased the flowability of MTA and did not interrupt the physical and biological effect of MTA. It suggests that these cements may be useful as a root-end filling material.
[Mh] Termos MeSH primário: Compostos de Alumínio/química
Compostos de Alumínio/farmacologia
Cloreto de Cálcio/farmacologia
Compostos de Cálcio/química
Compostos de Cálcio/farmacologia
Metilcelulose/farmacologia
Óxidos/química
Óxidos/farmacologia
Materiais Restauradores do Canal Radicular/química
Silicatos/química
Silicatos/farmacologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas/efeitos dos fármacos
Força Compressiva
Polpa Dentária/efeitos dos fármacos
Combinação de Medicamentos
Teste de Materiais
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Calcium Compounds); 0 (Drug Combinations); 0 (Oxides); 0 (Root Canal Filling Materials); 0 (Silicates); 0 (mineral trioxide aggregate); 9004-67-5 (Methylcellulose); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28745751
[Au] Autor:Thompson BR; Horozov TS; Stoyanov SD; Paunov VN
[Ad] Endereço:School of Mathematics and Physical Sciences (Chemistry), University of Hull, Hull, UK. V.N.Paunov@hull.ac.uk.
[Ti] Título:Structuring and calorie control of bakery products by templating batter with ultra melt-resistant food-grade hydrogel beads.
[So] Source:Food Funct;8(8):2967-2973, 2017 Aug 01.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report the use of a temperature insensitive, food-grade hydrogel to reduce the caloric density of pancakes that were prepared at temperatures much higher than the boiling point of water. This cheap, facile method utilises a mixed agar-methylcellulose hydrogel, which was blended to produce a slurry of hydrogel microbeads. The pancake batter was mixed with a controlled volume percentage of slurry of hydrogel beads and cooked. From bomb calorimetry experiments, the composites were found to have a reduced caloric density that reflects the volume percentage of hydrogel beads mixed with the batter. Using this procedure, we were able to reduce the caloric density of pancakes by up to 23 ± 3% when the volume percentage of hydrogel beads initially used was 25%. The method is not limited to pancakes and could potentially be applied to various other food products. The structure and morphology of the freeze-dried pancakes and pancake-hydrogel composites were investigated and pores of a similar size to the hydrogel beads were found, confirming that the gel beads maintained their structure during the cooking process. There is scope for further development of this method by the encapsulation of nutritionally beneficial or flavour enhancing ingredients within the hydrogel beads.
[Mh] Termos MeSH primário: Aditivos Alimentares/química
Hidrogel de Polietilenoglicol-Dimetacrilato/química
[Mh] Termos MeSH secundário: Testes Calóricos
Culinária
Farinha/análise
Análise de Alimentos
Temperatura Alta
Metilcelulose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives); 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 9004-67-5 (Methylcellulose)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00867h


  5 / 4098 MEDLINE  
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[PMID]:28715251
[Au] Autor:Shirata Y; Wakasa A; Miura K; Nakamura H; Matsumoto Y; Miyada T
[Ad] Endereço:a Division of Clinical Nutrition, Graduate School of Health Science and Technology , Kawasaki University of Medical Welfare , Kurashiki , Japan.
[Ti] Título:Body heat responsive gelation of methylcellulose formulation containing betaine.
[So] Source:Biosci Biotechnol Biochem;81(9):1829-1836, 2017 Sep.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We examined a methylcellulose (MC) formulation that gels at body temperature for enteral alimentation. Betaine was found to have a lowering effect on the gelation temperature of the MC solution. The thermal gelation temperature of a body heat-responsive (BHR) gelling MC formulation, consisting of 2% MC, 15% glucose, 1.2% sodium citrate, and 3.5% betaine mixture, was approximately 32 °C, indicating that it could gel in response to body heat. Glucose release from the BHR gels was delayed at 37 °C in an in vitro study. In rats, oral administration of BHR gelling MC formulation delayed an increase in blood glucose and appearance of CO in expired air in a C-acetate breath test in comparison with the control. These results suggested that the BHR gelling MC formulation was gelled in the stomach and delayed gastric emptying after oral administration and glucose in the gels was absorbed slowly.
[Mh] Termos MeSH primário: Betaína/química
Temperatura Corporal
Metilcelulose/química
Metilcelulose/farmacologia
[Mh] Termos MeSH secundário: Animais
Biomimética
Glicemia/metabolismo
Composição de Medicamentos
Esvaziamento Gástrico/efeitos dos fármacos
Géis
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/metabolismo
Intestino Delgado/fisiologia
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Gels); 3SCV180C9W (Betaine); 9004-67-5 (Methylcellulose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1347487


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[PMID]:28475444
[Au] Autor:Cutting KF
[Ad] Endereço:Clinical research consultant; Hertfordshire, Tissue Viability Specialist; First Community Health and Care, Surrey.
[Ti] Título:The cost-effectiveness of a novel soluble beta-glucan gel.
[So] Source:J Wound Care;26(5):228-234, 2017 May 02.
[Is] ISSN:0969-0700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Wounds that have stalled healing are costly in terms of patient morbidity and increase in use of material and financial resources. A natural polymer beta-glucans has been incorporated into a methylcellulose gel to provide a topical gel designed to accelerate healing in wounds where it has stalled. Although the gel provides an environment conducive to moist wound healing the active agent, beta-glucans, activate the innate immune response. METHOD: Using a Markov cohort simulation model, data were extrapolated from a double-blind randomised trial to evaluate the economic benefits of the soluble beta-glucan (SBG) gel in the treatment of diabetic foot ulcers (DFUs). RESULTS: Over an annual budget cycle, SBG gel is expected to heal 94% of wounds compared with 78% when given standard care. It also healed wounds more quickly, with the average expected healed weeks 34.4 in the SBG gel group, compared with 24.7 methylcellulose dressing group. In our model this leads to a cost saving over an annual budget cycle of £503 per patient. Note: healed weeks refers to the number of weeks when the wound has healed during the 12-week period and should not be confused with weeks to healing. CONCLUSION: The shorter healing time associated with the SBG gel treatment leads to a cost saving because fewer weeks of treatment are required to heal the wound, suggesting this is a promising new cost-effective option for the treatment of DFUs.
[Mh] Termos MeSH primário: Géis/uso terapêutico
Metilcelulose/uso terapêutico
Ferimentos e Lesões/tratamento farmacológico
beta-Glucanas/uso terapêutico
[Mh] Termos MeSH secundário: Administração Cutânea
Bandagens/economia
Estudos de Coortes
Simulação por Computador
Análise Custo-Benefício
Géis/economia
Seres Humanos
Cadeias de Markov
Metilcelulose/economia
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
Cicatrização
Ferimentos e Lesões/economia
beta-Glucanas/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gels); 0 (beta-Glucans); 9004-67-5 (Methylcellulose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE
[do] DOI:10.12968/jowc.2017.26.5.228


  7 / 4098 MEDLINE  
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[PMID]:28345979
[Au] Autor:Bardsley A
[Ad] Endereço:Senior Lecturer, Course Director Non-Medical Prescribing, Coventry University.
[Ti] Título:Assessment and treatment options for patients with constipation.
[So] Source:Br J Nurs;26(6):312-318, 2017 03 23.
[Is] ISSN:0966-0461
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Constipation is a common complaint for people of all ages, with prevalence increasing with age and during pregnancy. Women are more likely to be affected than men. Severity of constipation varies from person to person; most people experience short periods of constipation during their lives, including possibly after surgery, while others have constipation as a chronic long-term condition that can significantly affect their quality of life. There are a number of factors that can contribute to developing constipation including diets low in fibre, changes in lifestyle, side effects of certain medications and low fluid intake. People can successfully treat constipation by making changes to their diet and lifestyle. However, medication may be required to manage constipation for some.
[Mh] Termos MeSH primário: Constipação Intestinal/enfermagem
Dietoterapia
Laxantes/uso terapêutico
Avaliação em Enfermagem
[Mh] Termos MeSH secundário: Catárticos/uso terapêutico
Constipação Intestinal/diagnóstico
Constipação Intestinal/terapia
Gerenciamento Clínico
Seres Humanos
Lactulose/uso terapêutico
Metilcelulose/uso terapêutico
Peptídeos/uso terapêutico
Polietilenoglicóis/uso terapêutico
Qualidade de Vida
Extrato de Sena/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cathartics); 0 (Laxatives); 0 (Peptides); 30IQX730WE (Polyethylene Glycols); 4618-18-2 (Lactulose); 8013-11-4 (Senna Extract); 9004-67-5 (Methylcellulose); N0TXR0XR5X (linaclotide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.12968/bjon.2017.26.6.312


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[PMID]:28284427
[Au] Autor:Li Y; Zhang Y; Zhu CY
[Ad] Endereço:Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
[Ti] Título:Pharmacokinetics and correlation between in vitro release and in vivo absorption of bio-adhesive pellets of panax notoginseng saponins.
[So] Source:Chin J Nat Med;15(2):142-151, 2017 Feb.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The present study was designed to prepare and compare bio-adhesive pellets of panax notoginseng saponins (PNS) with hydroxy propyl methyl cellulose (HPMC), chitosan, and chitosan : carbomer, explore the influence of different bio-adhesive materials on pharmacokinetics behaviors of PNSbio-adhesive pellets, and evaluate the correlation between in vivo absorption and in vitro release (IVIVC). In order to predict the in vivo concentration-time profile by the in vitro release data of bio-adhesive pellets, the release experiment was performed using the rotating basket method in pH 6.8 phosphate buffer. The PNS concentrations in rat plasma were analyzed by HPLC-MS-MS method and the relative bioavailability and other pharmacokinetic parameters were estimated using Kinetica4.4 pharmacokinetic software. Numerical deconvolution method was used to evaluate IVIVC. Our results indicated that, compared with ordinary pellets, PNS bio-adhesive pellets showed increased oral bioavailability by 1.45 to 3.20 times, increased C , and extended MRT. What's more, the release behavior of drug in HPMC pellets was shown to follow a Fickian diffusion mechanism, a synergetic function of diffusion and skeleton corrosion. The in vitro release and the in vivo biological activity had a good correlation, demonstrating that the PNS bio-adhesive pellets had a better sustained release. Numerical deconvolution technique showed the advantage in evaluation of IVIVC for self-designed bio-adhesive pellets with HPMC. In conclusion, the in vitro release data of bio-adhesive pellets with HPMC can predict its concentration-time profile in vivo.
[Mh] Termos MeSH primário: Adesivos
Portadores de Fármacos
Absorção Intestinal
Panax notoginseng/química
Extratos Vegetais/farmacocinética
Saponinas/farmacocinética
[Mh] Termos MeSH secundário: Resinas Acrílicas
Animais
Quitosana
Liberação Controlada de Fármacos
Técnicas In Vitro
Masculino
Metilcelulose
Extratos Vegetais/administração & dosagem
Extratos Vegetais/metabolismo
Ratos Sprague-Dawley
Saponinas/administração & dosagem
Saponinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Adhesives); 0 (Drug Carriers); 0 (Plant Extracts); 0 (Saponins); 0 (carbomer); 9004-67-5 (Methylcellulose); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28275776
[Au] Autor:Borreani J; Espert M; Salvador A; Sanz T; Quiles A; Hernando I
[Ad] Endereço:Food Microstructure and Chemistry Research Group, Department of Food Technology, Universitat Politècnica de València, Camino de Vera, s/n, 46022, Valencia, Spain. jenbor@upvnet.upv.es mquichu@tal.upv.es mihernan@tal.upv.es.
[Ti] Título:Oil-in-water emulsions stabilised by cellulose ethers: stability, structure and in vitro digestion.
[So] Source:Food Funct;8(4):1547-1557, 2017 Apr 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of cellulose ethers in oil-in-water emulsions on stability during storage and on texture, microstructure and lipid digestibility during in vitro gastrointestinal digestion was investigated. All the cellulose ether emulsions showed good physical and oxidative stability during storage. In particular, the methylcellulose with high methoxyl substituents (HMC) made it possible to obtain emulsions with high consistency which remained almost unchanged during gastric digestion, and thus could enhance fullness and satiety perceptions at gastric level. Moreover, the HMC emulsion slowed down lipid digestion to a greater extent than a conventional protein emulsion or the emulsions stabilised by the other cellulose ethers. Therefore, HMC emulsions could be used in weight management to increase satiation capacity and decrease lipid digestion.
[Mh] Termos MeSH primário: Éteres/química
Metilcelulose/química
Óleos/química
Água/química
[Mh] Termos MeSH secundário: Digestão
Emulsões/química
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Ethers); 0 (Oils); 059QF0KO0R (Water); 9004-67-5 (Methylcellulose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00159b


  10 / 4098 MEDLINE  
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[PMID]:28263833
[Au] Autor:Kirsch K; Hanke U; Weitschies W
[Ad] Endereço:Universitiy of Greifswald, Center of Drug Absorption and Transport, Institute of Pharmacy, Felix-Hausdorff-Strasse 3, 17487 Greifswald, Germany.
[Ti] Título:Preparation and characterization of gastrointestinal wafer formulations.
[So] Source:Int J Pharm;522(1-2):165-171, 2017 Apr 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Many active pharmaceutical ingredients (API) have a very poor or highly variable bioavailability after oral administration. One possibility to overcome this problem might be found in the application of mucoadhesive dosage forms like gastrointestinal wafers. However, a currently unsolved challenge is the control of the adhesion of the wafer to the intestinal mucus. One suggested solution might be the combination of gastrointestinal wafers and expanding systems. Such a combination requires thin and elastic wafers which are further characterized by an unidirectional drug release. In this study gastrointestinal, twolayered wafers containing a water-insoluble backing layer and a drug-loaded, mucoadhesive layer were fabricated by casting solvent technique. The backing layer consists of Ethocel™ Standard 10 Premium and the mucoadhesive layer was prepared using a mixture of Methocel™ E15 Premium LV, polyvinyl alcohol and Macrogol 400. The wafers were characterized regarding their appearance, mechanical properties and dissolution profiles as well as the influence of backing layer thickness on drug transfer and their ability of unidirectional drug release. The wafers with backing layer thickness of 500µg Ethocel™/cm presented adequate mechanical properties, a drug transfer about 73% and unidirectional drug release.
[Mh] Termos MeSH primário: Composição de Medicamentos
Sistemas de Liberação de Medicamentos/métodos
Fármacos Gastrointestinais/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Disponibilidade Biológica
Mucosa Gástrica
Mucosa Intestinal
Metilcelulose
Polietilenoglicóis
Álcool de Polivinil
Solubilidade
Adesivos Teciduais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Agents); 0 (Tissue Adhesives); 30IQX730WE (Polyethylene Glycols); 9002-89-5 (Polyvinyl Alcohol); 9004-67-5 (Methylcellulose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE



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