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[PMID]:29422755
[Au] Autor:Maharana PK; Raghuwanshi S; Chauhan AK; Rai VG; Pattebahadur R
[Ad] Endereço:Department of Ophthalmology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
[Ti] Título:Comparison of the Efficacy of Carboxymethylcellulose 0.5%, Hydroxypropyl-guar Containing Polyethylene Glycol 400/Propylene Glycol, and Hydroxypropyl Methyl Cellulose 0.3% Tear Substitutes in Improving Ocular Surface Disease Index in Cases of Dry Eye.
[So] Source:Middle East Afr J Ophthalmol;24(4):202-206, 2017 Oct-Dec.
[Is] ISSN:0975-1599
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the efficacy of carboxymethylcellulose 0.5% (CMC), hydroxypropyl-guar containing polyethylene glycol 400/propylene glycol (PEG/PG), and hydroxypropyl methylcellulose 0.3% (HPMC) as tear substitutes in patients with dry eye. METHODS: A retrospective evaluation of cases presenting with symptoms of dry eye from July 2014 to June 2015 was done. Patients with Ocular Surface Disease Index (OSDI) scoring >12 were included in the study. Parameters such as age, gender, Schirmer test (ST), and tear film breakup time (TBUT) were recorded on day 0, week 1, and week 4. For analysis, cases were divided into three groups; Group 1 - CMC, Group 2 - PEG/PG, and Group 3 - HPMC. RESULTS: Overall, 120 patients were included in the study. Demographic data and baseline characteristics were comparable among the groups. Group 2 had significant improvement in percentage change in OSDI (weeks 0-1, 0-4, and 1-4, = 0.00), TBUT (weeks 0-1, = 0.01; 0-4, = 0.006; and 1-4, = 0.007), and in ST (weeks 0-1, = 0.02; 0-4, = 0.002; and 1-4, = 0.008) compared to Group 1 at all follow-ups. Group 3 had improvements similar to Group 2, but it was not at all follow-ups (improvement in percentage change OSDI [weeks 0-1, 0-4, and 1-4, = 0.00], TBUT [weeks 0-1, = 0.10; 0-4, = 0.03; and 1-4, = 0.04], and in ST [weeks 0-1, = 0.007; 0-4, = 0.03; and 1-4, = 0.12]). No significant difference was found between Groups 2 and 3. CONCLUSIONS: Hydroxypropyl-guar containing PEG/PG and HPMC as tear substitutes are better than CMC. While HPMC was comparable to PEG/PG in subjective improvement, the objective improvement was not consistent.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/administração & dosagem
Síndromes do Olho Seco/tratamento farmacológico
Derivados da Hipromelose/administração & dosagem
Lubrificantes Oftálmicos/administração & dosagem
Polissacarídeos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oftálmica
Adulto
Combinação de Medicamentos
Síndromes do Olho Seco/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Soluções Oftálmicas
Polietilenoglicóis/química
Polissacarídeos/química
Propilenoglicol/química
Estudos Retrospectivos
Lágrimas/fisiologia
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Lubricant Eye Drops); 0 (Ophthalmic Solutions); 0 (Polysaccharides); 0 (hydroxypropyl guar); 30IQX730WE (Polyethylene Glycols); 3NXW29V3WO (Hypromellose Derivatives); 6DC9Q167V3 (Propylene Glycol); B697894SGQ (polyethylene glycol 400); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE
[do] DOI:10.4103/meajo.MEAJO_165_15


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[PMID]:28452989
[Au] Autor:Labetoulle M; Chiambaretta F; Shirlaw A; Leaback R; Baudouin C
[Ad] Endereço:Service d'Ophtalmologie, CHU Bicêtre, APHP, Université Paris Sud, Paris, France.
[Ti] Título:Osmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: a randomised controlled trial in moderate to severe dry eye.
[So] Source:Eye (Lond);31(10):1409-1416, 2017 Oct.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PurposeTo assess the safety and efficacy of an eye drop combining osmoprotectants, carboxymethylcellulose and hyaluronic acid (O/CMC/HA) in reducing symptomatic, moderate to severe dry eye, compared with HA.MethodsIn this investigator-masked, randomised study, patients instilled 1-2 drops/eye of O/CMC/HA or HA (2-6 times/day) for 3 months. Primary endpoint: mean change in Global Ocular Staining Score (GOSS) from baseline at day 35. Noninferiority of O/CMC/HA was tested in the per-protocol population; if achieved, superiority was tested in the intent-to-treat population. Secondary efficacy endpoints: mean change from baseline in GOSS, Ocular Surface Disease Index (OSDI), Schirmer score, tear break-up time (TBUT), corneal/conjunctival staining, conjunctival hyperaemia, symptoms, and patient/investigator assessments.ResultsBaseline characteristics were comparable between groups (n=40 each). O/CMC/HA was noninferior (and not superior) to HA based on similar GOSS reductions from baseline at day 35 and month 3 in both groups (P=0.778, day 35, per-protocol population). Overall, O/CMC/HA and HA provided similar reductions in OSDI, Schirmer score, TBUT, corneal staining and hyperaemia from baseline at 35 days (P≥0.155). More patients reported less severe stinging/burning, sandiness/grittiness, and painful/sore eyes at month 3 with O/CMC/HA (P≤0.039), and more rated the dropper bottle easy to use (87.5%), compared with HA (46.2%; P=0.002). Other patient and investigator assessments were similar between groups. O/CMC/HA and HA were well tolerated.ConclusionsO/CMC/HA is noninferior to HA in improving objective signs of dry eye, with potential advantages for subjective symptoms and patient acceptance.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/administração & dosagem
Síndromes do Olho Seco/tratamento farmacológico
Ácido Hialurônico/administração & dosagem
Lágrimas/química
[Mh] Termos MeSH secundário: Carboximetilcelulose Sódica/farmacocinética
Relação Dose-Resposta a Droga
Esquema de Medicação
Síndromes do Olho Seco/diagnóstico
Feminino
Seres Humanos
Ácido Hialurônico/farmacocinética
Masculino
Meia-Idade
Soluções Oftálmicas/administração & dosagem
Osmose/efeitos dos fármacos
Índice de Gravidade de Doença
Resultado do Tratamento
Viscossuplementos/administração & dosagem
Viscossuplementos/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Ophthalmic Solutions); 0 (Viscosupplements); 9004-61-9 (Hyaluronic Acid); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2017.73


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[PMID]:29231041
[Au] Autor:Carroll TL; Dezube A; Bauman LA; Mallur PS
[Ad] Endereço:1 Department of Otolaryngology, Harvard Medical School, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
[Ti] Título:Using Trial Vocal Fold Injection to Select Vocal Fold Scar Patients Who May Benefit From More Durable Augmentation.
[So] Source:Ann Otol Rhinol Laryngol;127(2):105-112, 2018 Feb.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Clinical indications for vocal fold injection augmentation (VFI) are expanding. Prior studies demonstrate the benefit of trial VFI for select causes of glottic insufficiency. No studies have examined trial VFI for glottic insufficiency resulting from true vocal fold (TVF) scar. METHODS: Retrospective chart review of patients who underwent trial VFI for a dominant pathology of TVF scar causing dysphonia. Patients who subsequently underwent durable augmentation were identified. The primary study outcome was the difference in Voice Handicap Index-10 (VHI-10) score from pretrial VFI to post-durable augmentation. RESULTS: Twenty-eight patients underwent trial VFI for TVF scar, 22 of whom reported a positive response. Fifteen of 22 subjects who underwent durable augmentation had viable data for analysis. Mean VHI-10 improved from 26.9 to 18.6 ( P < .05), for a delta VHI-10 of 8.3, or 30.9% improvement. Twelve of the 15 (80%) showed a clinically significant improvement (delta VHI-10 >5). CONCLUSIONS: A trial VFI is a potentially useful, low-risk procedure that appears to help the patient and clinician identify when global augmentation might improve the voice when vocal fold scar is present. Patients who reported successful trial VFI often demonstrated significant improvement in their VHI-10 after subsequent durable augmentation.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/administração & dosagem
Cicatriz/terapia
Disfonia/terapia
Doenças da Laringe/terapia
Prega Vocal
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Cicatriz/complicações
Disfonia/etiologia
Feminino
Seguimentos
Seres Humanos
Injeções
Masculino
Meia-Idade
Satisfação do Paciente
Estudos Retrospectivos
Qualidade da Voz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417746188


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[PMID]:28709527
[Au] Autor:Mohammadi A; Nemati S; Mosaferi M; Abdollahnejhad A; Almasian M; Sheikhmohammadi A
[Ad] Endereço:Department of Environmental Health Engineering, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
[Ti] Título:Predicting the capability of carboxymethyl cellulose-stabilized iron nanoparticles for the remediation of arsenite from water using the response surface methodology (RSM) model: Modeling and optimization.
[So] Source:J Contam Hydrol;203:85-92, 2017 Aug.
[Is] ISSN:1873-6009
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study aimed to investigate the feasibility of carboxymethyl cellulose-stabilized iron nanoparticles (C-nZVI) for the removal of arsenite ions from aqueous solutions. Iron nanoparticles and carboxymethyl cellulose-stabilized iron nanoparticles were freshly synthesized. The synthesized nanomaterials had a size of 10nm approximately. The transmission electron microscope (TEM) images depicted bulkier dendrite flocs of non-stabilized iron nanoparticles. It described nanoscale particles as not discrete resulting from the aggregation of particles. The scanning electron microscopy (SEM) image showed that C-nZVI is approximately discrete, well-dispersed and an almost spherical shape. The energy dispersive x-ray spectroscopy (EDAX) and X-ray diffraction (XRD) spectrum confirmed the presence of Fe in the C-nZVI composite. The central composite design under the Response Surface Methodology (RSM) was employed in order to investigate the effect of independent variables on arsenite removal and to determine the optimum condition. The reduced full second-order model indicated a well-fitted model since the experimental values were in good agreement with it. Therefore, this model is used for the prediction and optimization of arsenite removal from water. The maximum removal efficiency was estimated to be 100% when all parameters are considered simultaneously. The predicted optimal conditions for the maximum removal efficiency were achieved with initial arsenite concentration, 0.68mgL ; C-nZVI, 0.3 (gL ); time, 31.25 (min) and pH, 5.2.
[Mh] Termos MeSH primário: Arsenitos/química
Carboximetilcelulose Sódica/química
Recuperação e Remediação Ambiental/métodos
Ferro/química
Nanopartículas Metálicas/química
[Mh] Termos MeSH secundário: Microscopia Eletrônica de Varredura
Modelos Teóricos
Espectrometria por Raios X
Água/química
Poluentes Químicos da Água/química
Purificação da Água/métodos
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenites); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); E1UOL152H7 (Iron); K679OBS311 (Carboxymethylcellulose Sodium); N5509X556J (arsenite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28673094
[Au] Autor:Laffleur F; Ijaz M; Menzel C
[Ad] Endereço:a Department of Pharmaceutical Technology , University of Innsbruck, Institute of Pharmacy , Innsbruck , Austria.
[Ti] Título:Screening of anionic-modified polymers in terms of stability, disintegration, and swelling behavior.
[So] Source:Drug Dev Ind Pharm;43(11):1866-1872, 2017 Nov.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to screen the stability, disintegration, and swelling behavior of chemically modified anionic polymers. Investigated polymers were well-known and widely used staples of the pharmaceutical and medical field, namely, alginate (AL), carboxymethyl cellulose (CMC), polycarbophil (PC), and hyaluronic acid (HA). On the basis of amide bond formation between the carboxylic acid moieties of anionic polymers and the primary amino group of the modification ligand cysteine (CYS), the modified polymers were obtained. Unmodified polymers served as controls throughout all studies. With the Ellman's assay, modification degrees were determined of synthesized polymeric excipients. Stability assay in terms of erosion study at physiological conditions were performed. Moreover, water uptake of compressed polymeric discs were evaluated and further disintegration studies according to the USP were carried out to define the potential ranking. Results ranking figured out PCCYS > CMCCYS > HACYS > ALCYS in terms of water uptake capacity compared to respective controls. Cell viability assays on Caco-2 cell line as well as on RPMI 2650 (ATTC CCL30) proved modification not being harmful to those. Due to the results of this study, an intense screening of prominent anionic polymer derivate was performed in order to help the pharmaceutical research for the best choice of polymeric excipients for developments of controlled drug release systems.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Alginatos/química
Ânions/química
Células CACO-2/química
Carboximetilcelulose Sódica/química
Cisteína/química
Excipientes/química
Ácido Hialurônico/química
Polímeros/química
[Mh] Termos MeSH secundário: Resinas Acrílicas/metabolismo
Alginatos/metabolismo
Carboximetilcelulose Sódica/metabolismo
Cisteína/metabolismo
Preparações de Ação Retardada
Sistemas de Liberação de Medicamentos
Ácido Glucurônico/química
Ácido Glucurônico/metabolismo
Ácidos Hexurônicos/química
Ácidos Hexurônicos/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Alginates); 0 (Anions); 0 (Delayed-Action Preparations); 0 (Excipients); 0 (Hexuronic Acids); 0 (Polymers); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 8F049NKY49 (calcium polycarbophil); 9004-61-9 (Hyaluronic Acid); K679OBS311 (Carboxymethylcellulose Sodium); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1349789


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[PMID]:28646437
[Au] Autor:Becaro AA; Siqueira MC; Puti FC; de Moura MR; Correa DS; Marconcini JM; Mattoso LHC; Ferreira MD
[Ad] Endereço:Programa de Pós-Graduação em Biotecnologia (PPGBiotec), Centro de Ciências Exatas e Tecnologia, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, 13565-905, Brazil.
[Ti] Título:Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa.
[So] Source:Environ Monit Assess;189(7):352, 2017 Jul.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Several mutagenic agents may be present in substances released in the environment, which may cause serious environmental impacts. Among these substances, there is a special concern regarding the widespread use of silver nanoparticles (AgNP) in several products due to their widely known bactericidal properties, including in the medical field and the food industry (e.g., active packaging). The assessment of the effects of AgNP released in the environment, having different concentrations, sizes, and being associated or not to other types of materials, including polymers, is therefore essential. In this research, the objective was to evaluate the genotoxic and cytotoxic effects of AgNP (size range between 2 and 8 nm) on root meristematic cells of Allium cepa (A. cepa). Tests were carried out in the presence of colloidal solution of AgNP and AgNP mixed with carboxymethylcellulose (CMC), using distinct concentrations of AgNP. As a result, when compared to control samples, AgNP induced a mitotic index decrease and an increase of chromosomal aberration number for two studied concentrations. When AgNP was in the presence of CMC, no cytotoxic potential was verified, but only the genotoxic potential for AgNP dispersion having concentration of 12.4 ppm.
[Mh] Termos MeSH primário: Allium/efeitos dos fármacos
Carboximetilcelulose Sódica/toxicidade
Nanopartículas Metálicas/toxicidade
Prata/toxicidade
[Mh] Termos MeSH secundário: Aberrações Cromossômicas
Dano ao DNA
Monitoramento Ambiental
Mutagênicos/toxicidade
Nanopartículas/toxicidade
Cebolas/efeitos dos fármacos
Raízes de Plantas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 3M4G523W1G (Silver); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6062-8


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[PMID]:28601319
[Au] Autor:Docherty JR; McCormick PA
[Ad] Endereço:Department of Physiology, Royal College of Surgeons in Ireland, Dublin 2, Ireland. Electronic address: docherty@rcsi.ie.
[Ti] Título:A carboxymethylcellulose-heparin combination for the prevention of surgical adhesions.
[So] Source:J Surg Res;213:228-233, 2017 Jun 01.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adhesions are a major clinical problem after abdominal surgery. Despite decades of research, therapies to prevent adhesion formation are suboptimal. MATERIALS AND METHODS: We have investigated combinations of carboxymethylcellulose (CMC) and heparin at preventing surgical adhesions in two rat models of adhesion formation. The first was the well-established cecal abrasion model, and the second was a model developed in our laboratory, the avascular mesenteric knot model. This model consistently produced adhesions at the knot in 90% of experiments and causes little or no tissue injury. RESULTS: Topical administration of CMC 4% gave optimal results in the avascular knot model, but was less effective in the cecal abrasion model. This concentration of CMC was combined with a range of heparin doses between 0.5 and 160 IU/mL in the cecal abrasion model. These heparin doses, apart from the lowest (0.5 IU/mL), were effective in preventing adhesion formation in combination with CMC, as was the commercially available topical product Lipactin. The optimal dose was 30 IU/mL, that abolished adhesions, but there was little difference at doses between 2 and 160 IU. Heparin was effective in doses as low as 2 IU/mL when in combination with CMC. Heparin 160 IU/mL, but not heparin 30 IU/mL or Lipactin, significantly increased the degree of bleeding post cecal abrasion surgery. CONCLUSIONS: Topical application of tiny doses of heparin, in combination with CMC 4% gel, significantly reduces adhesion formation in experimental models. We suggest that this cheap and, as far as we know, safe intervention should be evaluated in human clinical trials.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/uso terapêutico
Heparina/uso terapêutico
Complicações Pós-Operatórias/prevenção & controle
Substâncias Protetoras/uso terapêutico
Aderências Teciduais/prevenção & controle
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Relação Dose-Resposta a Droga
Combinação de Medicamentos
Masculino
Ratos
Ratos Wistar
Método Simples-Cego
Aderências Teciduais/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Protective Agents); 9005-49-6 (Heparin); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE


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[PMID]:28581895
[Au] Autor:Chaturvedi AA; Yauw STK; Lomme RMLM; Hendriks T; van Goor H
[Ad] Endereço:1 Department of Surgery, Radboud University Medical Centre , Nijmegen, The Netherlands .
[Ti] Título:Safety and Efficacy of Alginate Adhesion Barrier Gel in Compromised Intestinal Anastomosis.
[So] Source:Surg Infect (Larchmt);18(6):670-675, 2017 Aug/Sep.
[Is] ISSN:1557-8674
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: For any anti-adhesive barrier developed for abdominal surgery, the use under conditions in which anastomotic healing is compromised needs to be investigated. The current study evaluates the effect of a new ultrapure alginate gel on early healing of high-risk anastomoses in the ileum and compares this with the gold standard used in clinical practice. MATERIALS AND METHODS: In 75 adult male Wistar rats, a 5 mm ileal segment was resected and continuity was restored by construction of an inverted anastomosis. Rats were divided randomly into a control group and groups receiving either alginate gel or a sodium hyaluronate carboxymethylcellulose (HA/CMC) film around the anastomosis (n = 25 each). Carprofen, given in a daily dose of 1.25 mg/kg, was used to compromise anastomotic healing. At day three, animals were killed and scored for signs of anastomotic leakage and the presence of adhesions. RESULTS: The incidence of adhesion formation was 95% in the HA/CMC film group, which was significantly higher than in the controls (64%, p = 0.010) and the alginate gel group (52%, p = 0.004). The adhesion score was nearly 40% lower in the alginate gel group compared with the HA/CMC film group. The incidence of ileal leakage in the HA/CMC film group (92%) was significantly higher than in the controls (68%, p = 0.016). Leakage rate did not differ between the alginate gel and control groups. There was no significant difference between groups in either incision bursting pressure or incision breaking strength. CONCLUSION: Ultrapure alginate gel does not interfere with repair of ileal anastomoses constructed under conditions in which chances of anastomotic dehiscence are high. The alginate gel performs better than the HA/CMC film.
[Mh] Termos MeSH primário: Alginatos/farmacologia
Alginatos/uso terapêutico
Anastomose Cirúrgica/métodos
Íleo/efeitos dos fármacos
Aderências Teciduais/tratamento farmacológico
Aderências Teciduais/prevenção & controle
[Mh] Termos MeSH secundário: Anastomose Cirúrgica/efeitos adversos
Fístula Anastomótica
Animais
Carboximetilcelulose Sódica
Ácido Glucurônico/farmacologia
Ácido Glucurônico/uso terapêutico
Ácidos Hexurônicos/farmacologia
Ácidos Hexurônicos/uso terapêutico
Ácido Hialurônico
Íleo/cirurgia
Masculino
Peritonite/tratamento farmacológico
Peritonite/prevenção & controle
Distribuição Aleatória
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Hexuronic Acids); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 9004-61-9 (Hyaluronic Acid); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1089/sur.2016.086


  9 / 2554 MEDLINE  
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[PMID]:28581832
[Au] Autor:Soulairol I; Chaheen M; Tarlier N; Aubert A; Bataille B; Sharkawi T
[Ad] Endereço:a UMR 5253, Equipe MACS, ICGM, University of Montpellier , Montpellier , France.
[Ti] Título:Evaluation of disintegrants functionality for orodispersible mini tablets.
[So] Source:Drug Dev Ind Pharm;43(11):1770-1779, 2017 Nov.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This work evaluates the functionalities of different superdisintegrants (SD) for manufacturing orodispersible mini tablets (ODMT) by direct compression. METHODS: Twenty-three formulations varying in SD type, concentration, and lubricant were used to manufacture ODMT. The ODMT were then characterized for the following properties: friability, porosity, tensile strength, in vivo and in vitro disintegration time (DT). RESULTS: The results show that the presence, type, and concentration of SD did not influence friability, porosity, or tablet tensile strength. With regards to in vivo DT, only cross-linked poly (vinyl pyrrolidone) improved DT in all the tested formulations. Results also showed that when using microcrystalline cellulose (MCC) above 20% in the formulation, DT is longer. Cross-linked carboxymethyl cellulose accelerates DT when the MCC content is less than 20%. As for cross-linked carboxymethyl starch and calcium alginate showed no improvement on DT. Results for in vitro DT were all shorter than in vivo results and there was no correlation with the in vivo evaluation. CONCLUSIONS: This study shows that there is a need to develop better in vitro testing that precisely simulates in vivo conditions and that are adapted to ODMT. This standardization of the test methods for ODMTs must be accompanied by an improvement in the comprehension of SD mechanisms.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/química
Celulose/química
Química Farmacêutica/métodos
Excipientes/química
Povidona/química
Amido/análogos & derivados
Comprimidos/química
Resistência à Tração/fisiologia
[Mh] Termos MeSH secundário: Celulose/metabolismo
Composição de Medicamentos
Porosidade
Amido/química
Amido/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Tablets); 9004-34-6 (Cellulose); 9005-25-8 (Starch); 9057-06-1 (carboxymethyl starch); FZ989GH94E (Povidone); K679OBS311 (Carboxymethylcellulose Sodium); OP1R32D61U (microcrystalline cellulose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1339081


  10 / 2554 MEDLINE  
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[PMID]:28490133
[Au] Autor:Koushesh Saba M; Amini R
[Ad] Endereço:Department of Horticultural Science, University of Kurdistan, P.O. Box 416, Sanandaj, Iran. Electronic address: m.saba@uok.ac.ir.
[Ti] Título:Nano-ZnO/carboxymethyl cellulose-based active coating impact on ready-to-use pomegranate during cold storage.
[So] Source:Food Chem;232:721-726, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Minimally processed pomegranate rapidly loses its overall quality because of high water loss and microbial contamination. Nano-ZnO in combination with carboxymethyl cellulose (CMC) coating was used on pomegranate arils. Arils were dipped for 4min in distilled water (control), 0.1 or 0.2% (w/v) nano-ZnO suspension and then ZnO treated arils were coated with 0.5% (w/v) CMC and stored for 12days at 4°C. Coatings decreased total yeast+mold during 12days of storage while total mesophilic bacteria was decreased during 6days of storage. Coatings decreased weight loss and also the greatest juice percent was in coated arils. Soluble solids content decreased during storage with no significant difference between treatments. CMC+0.2% nano-ZnO suppressed total phenol changes. Total anthocyanin, vitamin C, and antioxidant capacity were higher in coated arils. These findings suggest that nano-ZnO+CMC coating has the potential to extend minimally processed pomegranate storage life.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica
Conservação de Alimentos
Punicaceae
[Mh] Termos MeSH secundário: Antocianinas
Frutas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE



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