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[PMID]: | 29236491 |
[Au] Autor: | Hung TV; Suzuki T |
[Ad] Endereço: | Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University , Higashihiroshima 739-8528, Japan. |
[Ti] Título: | Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons. |
[So] Source: | J Agric Food Chem;66(1):108-117, 2018 Jan 10. | [Is] ISSN: | 1520-5118 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, play an important role in the maintenance of intestinal homeostasis. In the present study, anti-inflammatory effects of SCFAs were examined in human intestinal Caco-2 cells and mouse colonic cultures. Stimulation of Caco-2 cells with tumor necrosis factor (TNF)-α induced interleukin (IL)-8 (TNF-α, 17.1 ± 7.2 vs Control, 1.00 ± 0.26, P < 0.01) and IL-6 expression (TNF-α, 21.7 ± 10.0 vs Control, 1.00 ± 0.28, P < 0.01) through the activation of nuclear factor κB p65, spleen tyrosine kinase, and mitogen-activated protein kinase pathways. Pretreatment of cells with acetate (5 mM, IL-8 1.23 ± 0.40, IL-6 2.19 ± 0.92, P < 0.01 ), propionate (2.5 mM, IL-8 2.45 ± 2.10, IL-6 2.19 ± 0.92, P < 0.01), or butyrate (0.625 mM, IL-8 1.44 ± 0.70, IL-6 2.31 ± 0.32, P < 0.01) suppressed inflammatory responses induced by TNF-α. Pharmacological inhibition of monocarboxylate transporter (MCT)-1 attenuated the suppression of inflammatory signals by SCFAs. High expression levels of CXC motif chemokine ligand 2 (CXCL2, an IL-8 homologue, DSS, 31.7 ± 9.8 vs Control, 1.00 ± 0.70, P < 0.01) and IL-6 (DSS, 17.5 ± 7.2 vs Control, 1.00 ± 0.68, P < 0.01) were observed in BALB/c mouse colonic cultures exposed to dextran sodium sulfate, whereas treatments with mixtures of SCFAs decreased these elevated expression levels (CXCL2 4.14 ± 2.88, IL-6 0.58 ± 0.28, P < 0.01). Our results suggest that SCFAs transported by MCT-1 suppress TNF-α-induced inflammatory signaling in intestinal cells. |
[Mh] Termos MeSH primário: |
Anti-Inflamatórios não Esteroides/farmacologia Colite/tratamento farmacológico Colo/efeitos dos fármacos Ácidos Graxos Voláteis/farmacologia
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[Mh] Termos MeSH secundário: |
Animais Células CACO-2 Colite/induzido quimicamente Colite/metabolismo Colo/metabolismo Colo/patologia Citocinas/metabolismo Sulfato de Dextrana/toxicidade Seres Humanos Interleucina-6/metabolismo Interleucina-8/metabolismo Masculino Camundongos Endogâmicos BALB C Proteínas/metabolismo Fator de Necrose Tumoral alfa/farmacologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Fatty Acids, Volatile); 0 (Interleukin-6); 0 (Interleukin-8); 0 (Proteins); 0 (Tumor Necrosis Factor-alpha); 9042-14-2 (Dextran Sulfate) |
[Em] Mês de entrada: | 1802 |
[Cu] Atualização por classe: | 180215 |
[Lr] Data última revisão:
| 180215 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 171214 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1021/acs.jafc.7b04233 |
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