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  1 / 10019 MEDLINE  
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[PMID]:29335514
[Au] Autor:Kaiser M; Jug F; Julou T; Deshpande S; Pfohl T; Silander OK; Myers G; van Nimwegen E
[Ad] Endereço:Biozentrum, University of Basel and Swiss Institute of Bioinformatics, Klingelbergstrasse 50/70, 4056, Basel, Switzerland.
[Ti] Título:Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software.
[So] Source:Nat Commun;9(1):212, 2018 01 15.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Much is still not understood about how gene regulatory interactions control cell fate decisions in single cells, in part due to the difficulty of directly observing gene regulatory processes in vivo. We introduce here a novel integrated setup consisting of a microfluidic chip and accompanying analysis software that enable long-term quantitative tracking of growth and gene expression in single cells. The dual-input Mother Machine (DIMM) chip enables controlled and continuous variation of external conditions, allowing direct observation of gene regulatory responses to changing conditions in single cells. The Mother Machine Analyzer (MoMA) software achieves unprecedented accuracy in segmenting and tracking cells, and streamlines high-throughput curation with a novel leveraged editing procedure. We demonstrate the power of the method by uncovering several novel features of an iconic gene regulatory program: the induction of Escherichia coli's lac operon in response to a switch from glucose to lactose.
[Mh] Termos MeSH primário: Regulação Bacteriana da Expressão Gênica
Técnicas Analíticas Microfluídicas/métodos
Análise de Célula Única/métodos
Software
[Mh] Termos MeSH secundário: Algoritmos
Rastreamento de Células/instrumentação
Rastreamento de Células/métodos
Escherichia coli/citologia
Escherichia coli/efeitos dos fármacos
Escherichia coli/genética
Glucose/farmacologia
Óperon Lac/genética
Lactose/farmacologia
Análise de Célula Única/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
IY9XDZ35W2 (Glucose); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02505-0


  2 / 10019 MEDLINE  
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[PMID]:29111498
[Au] Autor:Malek R; Bonnarme P; Irlinger F; Frey-Klett P; Onésime D; Aubert J; Loux V; Beckerich JM
[Ad] Endereço:UMR 1319 MICALIS, INRA, AgroParisTech, CBAI, BP01, 78850 Thiverval Grignon, France. Electronic address: reinemalek@hotmail.com.
[Ti] Título:Transcriptomic response of Debaryomyces hansenii during mixed culture in a liquid model cheese medium with Yarrowia lipolytica.
[So] Source:Int J Food Microbiol;264:53-62, 2018 Jan 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Yeasts play a crucial role in cheese ripening. They contribute to the curd deacidification, the establishment of acid-sensitive bacterial communities, and flavour compounds production via proteolysis and catabolism of amino acids (AA). Negative yeast-yeast interaction was observed between the yeast Yarrowia lipolytica 1E07 (YL1E07) and the yeast Debaryomyces hansenii 1L25 (DH1L25) in a model cheese but need elucidation. YL1E07 and DH1L25 were cultivated in mono and co-cultures in a liquid synthetic medium (SM) mimicking the cheese environment and the growth inhibition of DH1L25 in the presence of YL1E07 was reproduced. We carried out microbiological, biochemical (lactose, lactate, AA consumption and ammonia production) and transcriptomic analyses by microarray technology to highlight the interaction mechanisms. We showed that the DH1L25 growth inhibition in the presence of YL1E07 was neither due to the ammonia production nor to the nutritional competition for the medium carbon sources between the two yeasts. The transcriptomic study was the key toward the comprehension of yeast-yeast interaction, and revealed that the inhibition of DH1L25 in co-culture is due to a decrease of the mitochondrial respiratory chain functioning.
[Mh] Termos MeSH primário: Queijo/microbiologia
Debaromyces/crescimento & desenvolvimento
Debaromyces/metabolismo
Perfilação da Expressão Gênica/métodos
Yarrowia/crescimento & desenvolvimento
Yarrowia/metabolismo
[Mh] Termos MeSH secundário: Aminoácidos/metabolismo
Amônia/metabolismo
Técnicas de Cocultura
Debaromyces/genética
Aromatizantes/análise
Microbiologia de Alimentos
Ácido Láctico/metabolismo
Lactose/metabolismo
Interações Microbianas/genética
Interações Microbianas/fisiologia
Transcriptoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Flavoring Agents); 33X04XA5AT (Lactic Acid); 7664-41-7 (Ammonia); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171108
[St] Status:MEDLINE


  3 / 10019 MEDLINE  
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[PMID]:29247504
[Au] Autor:Gallegos-Tabanico A; Sarabia-Sainz JA; Sarabia-Sainz HM; Carrillo Torres R; Guzman-Partida AM; Monfort GR; Silva-Campa E; Burgara-Estrella AJ; Angulo-Molina A; Acosta-Elias M; Pedroza-Montero M; Vazquez-Moreno L
[Ad] Endereço:Departamento de Física, Universidad de Sonora, Hermosillo, Sonora, 83000, México.
[Ti] Título:Molecular recognition of glyconanoparticles by RCA and E. coli K88 - designing transports for targeted therapy.
[So] Source:Acta Biochim Pol;64(4):671-677, 2017.
[Is] ISSN:1734-154X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The targeted drug delivery has been studied as one of the main methods in medicine to ensure successful treatments of diseases. Pharmaceutical sciences are using micro or nano carriers to obtain a controlled delivery of drugs, able to selectively interact with pathogens, cells or tissues. In this work, we modified bovine serum albumin (BSA) with lactose, obtaining a neoglycan (BSA-Lac). Subsequently, we synthesized glyconanoparticles (NPBSA-Lac) with the premise that it would be recognized by microbial galactose specific lectins. NPBSA-Lac were tested for bio-recognition with adhesins of E. coli K88 and Ricinus communis agglutinin I (RCA). Glycation of BSA with lactose was analyzed by electrophoresis, infrared spectroscopy and fluorescence. Approximately 41 lactoses per BSA molecule were estimated. Nanoparticles were obtained using water in oil emulsion method and spheroid morphology with a range size of 300-500 nm was observed. Specific recognition of NPBSA-Lac by RCA and E. coli K88 was displayed by aggregation of nanoparticles analyzed by dynamic light scattering and atomic force microscopy. The results indicate that the lactosylated nanovectors could be targeted at the E. coli K88 adhesin and potentially could be used as a transporter for an antibacterial drug.
[Mh] Termos MeSH primário: Antígenos de Bactérias/metabolismo
Portadores de Fármacos/metabolismo
Proteínas de Escherichia coli/metabolismo
Proteínas de Fímbrias/metabolismo
Nanopartículas/química
Lectinas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Portadores de Fármacos/química
Eletroforese em Gel de Poliacrilamida
Escherichia coli/metabolismo
Lactose/química
Microscopia de Força Atômica
Peso Molecular
Tamanho da Partícula
Soroalbumina Bovina/química
Espectrofotometria Infravermelho
Espectroscopia de Infravermelho com Transformada de Fourier
Triptofano/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Drug Carriers); 0 (Escherichia coli Proteins); 0 (K88 antigen, E coli); 0 (Plant Lectins); 0 (Ricinus communis agglutinin-1); 147680-16-8 (Fimbriae Proteins); 27432CM55Q (Serum Albumin, Bovine); 8DUH1N11BX (Tryptophan); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.18388/abp.2017_1639


  4 / 10019 MEDLINE  
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[PMID]:28470620
[Au] Autor:Wurm DJ; Herwig C; Spadiut O
[Ad] Endereço:Research Division Biochemical Engineering, Institute of Chemical Engineering, TU Wien, Gumpendorfer Strasse 1a, 1060, Vienna, Austria.
[Ti] Título:How to Determine Interdependencies of Glucose and Lactose Uptake Rates for Heterologous Protein Production with E. coli.
[So] Source:Methods Mol Biol;1586:397-408, 2017.
[Is] ISSN:1940-6029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Induction by lactose is known to have a beneficial effect on the expression of soluble recombinant proteins in E. coli harboring the T7 expression system (e.g., E. coli BL21(DE3)). As lactose is a metabolizable inducer, it needs to be supplied continuously to prevent depletion and thus only partial induction. Overfeeding and accumulation of lactose or glucose on the other hand can lead to osmotic stress. Thus, it is of utmost importance to know the possible feeding ranges. Here, we show a fast method using a simple mechanistic model to characterize E. coli strains harboring the T7 expression system regarding their ability to take up lactose and glucose. This approach reduces experimental work and the gained data allows running a stable and robust bioprocess without accumulation of lactose or glucose.
[Mh] Termos MeSH primário: Escherichia coli/metabolismo
Glucose/metabolismo
Lactose/metabolismo
[Mh] Termos MeSH secundário: Técnicas de Cultura Celular por Lotes/métodos
Transporte Biológico
Reatores Biológicos
Escherichia coli/genética
Escherichia coli/crescimento & desenvolvimento
Expressão Gênica
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Recombinant Proteins); IY9XDZ35W2 (Glucose); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/978-1-4939-6887-9_26


  5 / 10019 MEDLINE  
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[PMID]:29199222
[Au] Autor:Hosaka S; Tokunaga Y
[Ad] Endereço:Research and Development Division, Sawai Pharmaceutical Co., Ltd.
[Ti] Título:Differences in Powder Properties of Two 1,4-Dihydropyridine-Type Compounds Evaluated through Thermal Analysis.
[So] Source:Chem Pharm Bull (Tokyo);65(12):1175-1178, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The powder properties of two 1,4-dihydropyridine type compounds, manidipine dihydrochloride (Man) and benidipine hydrochloride (Ben), which possess similar physicochemical properties, were compared through thermal and mechanical analyses. Man and Ben were compressed with lactose monohydrate (Lac) and magnesium stearate (Mgst) at different compression forces. As an index, we focused on the onset temperatures of Lac dehydration during thermal analysis and plotted them against compression forces to evaluate the differences in powder properties between Man and Ben. To discuss in detail, the Lac ratio was selected as a formulation factor and compression speed as a process factor, which would be influenced to the onset temperature or its profile. It could be represented that Man was more adherent than Ben through thermal analysis by changing these critical factors, which were consistent with the results obtained through mechanical analysis.
[Mh] Termos MeSH primário: Di-Hidropiridinas/química
Nifedipino/análogos & derivados
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Força Compressiva
Lactose/química
Nifedipino/química
Ácidos Esteáricos/química
Comprimidos/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dihydropyridines); 0 (Stearic Acids); 0 (Tablets); 0A6746FWDL (benidipine hydrochloride); 4ELV7Z65AP (stearic acid); 6O4754US88 (manidipine); I9ZF7L6G2L (Nifedipine); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00375


  6 / 10019 MEDLINE  
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[PMID]:29198188
[Au] Autor:Pimentel G; Burton KJ; Rosikiewicz M; Freiburghaus C; von Ah U; Münger LH; Pralong FP; Vionnet N; Greub G; Badertscher R; Vergères G
[Ad] Endereço:1Agroscope,Schwarzenburgstrasse 161,3003 Bern,Switzerland.
[Ti] Título:Blood lactose after dairy product intake in healthy men.
[So] Source:Br J Nutr;118(12):1070-1077, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The absence of a dedicated transport for disaccharides in the intestine implicates that the metabolic use of dietary lactose relies on its prior hydrolysis at the intestinal brush border. Consequently, lactose in blood or urine has mostly been associated with specific cases in which the gastrointestinal barrier is damaged. On the other hand, lactose appears in the blood of lactating women and has been detected in the blood and urine of healthy men, indicating that the presence of lactose in the circulation of healthy subjects is not incompatible with normal physiology. In this cross-over study we have characterised the postprandial kinetics of lactose, and its major constituent, galactose, in the serum of fourteen healthy men who consumed a unique dose of 800 g milk or yogurt. Genetic testing for lactase persistence and microbiota profiling of the subjects were also performed. Data revealed that lactose does appear in serum after dairy intake, although with delayed kinetics compared with galactose. Median serum concentrations of approximately 0·02 mmol/l lactose and approximately 0·2 mmol/l galactose were observed after the ingestion of milk and yogurt respectively. The serum concentrations of lactose were inversely correlated with the concentrations of galactose, and the variability observed between the subjects' responses could not be explained by the presence of the lactase persistence allele. Finally, lactose levels have been associated with the abundance of the Veillonella genus in faecal microbiota. The measurement of systemic lactose following dietary intake could provide information about lactose metabolism and nutrient transport processes under normal or pathological conditions.
[Mh] Termos MeSH primário: Dieta
Lactose/sangue
Leite
Iogurte
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alelos
Animais
Estudos Cross-Over
Método Duplo-Cego
Fezes/microbiologia
Galactose/sangue
Microbioma Gastrointestinal
Seres Humanos
Intestinos/metabolismo
Intestinos/microbiologia
Masculino
Período Pós-Prandial
Veillonella/isolamento & purificação
Adulto Jovem
beta-Galactosidase/genética
beta-Galactosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
EC 3.2.1.23 (beta-Galactosidase); J2B2A4N98G (Lactose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003245


  7 / 10019 MEDLINE  
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[PMID]:28831840
[Au] Autor:Patil S; Mahadik A; Nalawade P; More P
[Ad] Endereço:a Department of Pharmaceutics, Poona College of Pharmacy , Bharati Vidyapeeth University , Pune , India.
[Ti] Título:Crystal engineering of lactose using electrospray technology: carrier for pulmonary drug delivery.
[So] Source:Drug Dev Ind Pharm;43(12):2085-2091, 2017 Dec.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Dry powder inhalers (DPIs) consisting of a powder mixture containing coarse carrier particles (generally lactose) and micronized drug particles are used for lung drug delivery. The effective drug delivery to the lungs depends on size and shape of carrier particles. Thus, various methods have been proposed for engineering lactose particles to enhance drug delivery to lungs. OBJECTIVE: The objective of current work was to assess suitability of electrospray technology toward crystal engineering of lactose. Further, utility of the prepared lactose particles as a carrier in DPI was evaluated. MATERIALS AND METHODS: Saturated lactose solutions were electrosprayed to obtain electrosprayed lactose (EL) particles. The polymorphic form of EL was determined using Fourier transform infrared spectroscopy, powder X-ray diffractometry, and differential scanning calorimetry. In addition, morphological, surface textural, and flow properties of EL were determined using scanning electron microscopy and Carr's index, respectively. The aerosolization properties of EL were determined using twin-stage impinger and compared with commercial lactose particles [Respitose (SV003, Goch, Germany)] used in DPI formulations. RESULTS AND DISCUSSION: EL was found to contain both isomers (α and ß) of lactose having flow properties comparable to Respitose (SV003). In addition, the aerosolization properties of EL were found to be significantly improved when compared to Respitose (SV003) which could be attributed to morphological (high elongation ratio) and surface characteristic (smooth surface) alterations induced by electrospray technology. CONCLUSION: Electrospray technology can serve as an alternative technique for continuous manufacturing of engineered lactose particles which can be used as a carrier in DPI formulations.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos
Lactose/química
Pulmão/metabolismo
Microscopia Eletrônica de Varredura/métodos
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Química Farmacêutica
Cristalização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
J2B2A4N98G (Lactose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1371733


  8 / 10019 MEDLINE  
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[PMID]:28821180
[Au] Autor:Schwartz C; Chabanet C; Szleper E; Feyen V; Issanchou S; Nicklaus S
[Ad] Endereço:Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Université Bourgogne Franche-Comté, 17 rue Sully, BP 86510, 21065 Dijon cedex, France.
[Ti] Título:Infant Acceptance of Primary Tastes and Fat Emulsion: Developmental Changes and Links with Maternal and Infant Characteristics.
[So] Source:Chem Senses;42(7):593-603, 2017 Sep 01.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies on taste acceptance have been conducted taste-by-taste and with a cross-sectional design. The aim of this study was to longitudinally evaluate the acceptance of sweet, salty, bitter, sour and umami solutions, and a fat emulsion comparatively in a birth cohort from 3 to 20 months old. The acceptance of each taste relative to water was defined using proportional variables that are based on ingestion (IR) or liking evaluated by the experimenter (LR). These data were analyzed with mixed models that accounted for age and subject effects (minimum 152 observations/age/taste; maximum 216). For saltiness, acceptance increased sharply between 3 and 12 months old. The trajectories of acceptance were parallel for sweetness, sourness, and the umami tastes between 3 and 20 months old, with sweetness being preferred. Between 12 and 20 months old, the acceptance of all tastes, except bitterness, decreased, and at 20 months old, only sweetness was not rejected. The acceptance of bitterness remained stable. For the fat emulsion, acceptance evolved from indifference to rejection. The acceptance of saltiness and umami tastes were lower in girls than boys at 20 months old. The acceptance of the fat emulsion was higher in infants who were born heavier and taller. At 20 months old, the fat emulsion acceptance was higher in infants who were born from mothers with a higher prepregnancy body mass index. Finally, the taste differential reactivity (the standard deviation of the IRs) significantly increased from 3 to 20 months old.
[Mh] Termos MeSH primário: Óleos Vegetais/farmacologia
Paladar/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Índice de Massa Corporal
Ácido Cítrico/farmacologia
Estudos Transversais
Feminino
Preferências Alimentares/efeitos dos fármacos
Seres Humanos
Lactente
Lactose/farmacologia
Masculino
Mães
Fatores Sexuais
Cloreto de Sódio/farmacologia
Glutamato de Sódio/farmacologia
Percepção Gustatória
Ureia/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 2968PHW8QP (Citric Acid); 451W47IQ8X (Sodium Chloride); 8W8T17847W (Urea); J2B2A4N98G (Lactose); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1093/chemse/bjx040


  9 / 10019 MEDLINE  
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[PMID]:28768941
[Au] Autor:Kawakami M; Kitada R; Kurita T; Tokumura T
[Ad] Endereço:Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:A Method for Decreasing the Amount of the Drug Remaining on the Surfaces of the Mortar and Pestle after Grinding Small Amount of Tablets.
[So] Source:Yakugaku Zasshi;137(8):1017-1025, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The aim of the present study was to develop a method for grinding tablets with a mortar and pestle while reducing drug loss because grinding tablets is known to be associated with reductions in tablet weight and loss of the active drug. Seven kinds of tablets were subjected to grinding. The proportion (%) of the amount of the active drug in the powder remaining on the surfaces of the mortar and pestle relative to the total amount of the drug recovered (the recovery percent) was calculated. The recovery percent of the 7 kinds of tablets ranged from 17.2-35.9%, and the tablets' recovery percent decreased as the tablet weight increased. When the grinding was performed with 1 g of lactose monohydrate or 1 g of D-mannitol moistened with water, the recovery percent of the tablets decreased to 2.6-9.9% and 3.8-9.9%, respectively. The effects of the weight of lactose monohydrate on the recovery percent of Allegra 60 mg tablets were examined. It was found that at least 0.6 g of lactose monohydrate was required to have a sufficient effect on drug recovery. Therefore, additives that have stronger effects at lower amounts were sought. As a result, calcium monohydrogen phosphate was found to have the strongest effect on drug recovery. The addition of 0.4 g calcium monohydrogen phosphate resulted in the recovery percent of 5.1%, which was significantly lower than that of 15.0% observed after the addition of 0.4 g lactose monohydrate, and lower than the 6.8% of 1 g lactose monohydrate.
[Mh] Termos MeSH primário: Fosfatos de Cálcio
Composição de Medicamentos/instrumentação
Composição de Medicamentos/métodos
Excipientes
Comprimidos
Terfenadina/análogos & derivados
[Mh] Termos MeSH secundário: Adsorção
Lactose
Manitol
Pós
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Excipients); 0 (Powders); 0 (Tablets); 3OWL53L36A (Mannitol); 7BA5G9Y06Q (Terfenadine); E6582LOH6V (fexofenadine); J2B2A4N98G (Lactose); O7TSZ97GEP (calcium phosphate, dibasic, dihydrate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00041


  10 / 10019 MEDLINE  
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[PMID]:28763964
[Au] Autor:Kondor A; Hogan SA
[Ad] Endereço:Surface Measurement Systems Ltd., 5 Wharfside Rosemont Road, HA0 4PE London, UK.
[Ti] Título:Relationships between surface energy analysis and functional characteristics of dairy powders.
[So] Source:Food Chem;237:1155-1162, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Surface energetics of demineralised whey (DMW), skimmed milk (SMP), phosphocasein (PCN) and infant milk formula (IMF) powders were determined by inverse gas chromatography (IGC). All four milk powders were amphoteric in nature with the dispersive (apolar) component of surface energy dominating the specific (polar) contribution. PCN and IMF had the highest and lowest extent of surface heterogeneity, respectively. PCN also demonstrated the poorest functional properties of the powders examined. In contrast, IMF had excellent flow and rehydration properties. Thermodynamic work of cohesion was highest in PCN and may have contributed to inadequate rehydration behaviour. Glass transition temperature of IMF powder, determined by IGC, suggested a surface dominated by lactose. Surface heterogeneity provided a better indicator of functional behaviour than total surface energy. IGC is a useful complementary technique for chemical and structural analysis of milk powders and allows improved insight into the contribution of surface and bulk factors to functionality.
[Mh] Termos MeSH primário: Leite/química
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa
Lactose
Pós
Propriedades de Superfície
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Powders); J2B2A4N98G (Lactose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE



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