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[PMID]:29428599
[Au] Autor:Bukhari SHF; Clark OE; Williamson LL
[Ad] Endereço:Psychology Department, Williams College, Williamstown, MA 01267, United States.
[Ti] Título:Maternal high fructose diet and neonatal immune challenge alter offspring anxiety-like behavior and inflammation across the lifespan.
[So] Source:Life Sci;197:114-121, 2018 Mar 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: This study examined the interaction between maternal high fructose diet and neonatal inflammation in neonates (P7), juveniles (P26-34) and adults on measures of anxiety-like behavior and cognition. The study aimed to assess the potential synergistic effects of these two forms of early-life inflammation. MAIN METHODS: We fed Sprague-Dawley dams with high fructose (60%) diet or normal chow. Each litter was treated with either saline or lipopolysaccharide (LPS) on postnatal day (P)3 and P5 and two pups were tested for USVs after maternal separation on P7. Post-weaning, juveniles were tested on the elevated zero maze (EZM) and in a context-object discrimination (COD) task prior to tissue harvest. Adults were tested on the EZM and the COD task as well. Immunohistochemistry and ELISA were used to assess molecular and cellular changes in the offspring. KEY FINDINGS: This study demonstrates that maternal diet and neonatal inflammation altered peripheral inflammation in neonates, altered anxiety-like behavior in juveniles, and altered anxiety-like behavior in adulthood. Maternal diet and sex increased juvenile peripheral inflammation and altered memory on the context-discrimination task. SIGNIFICANCE: Maternal diet has a profound impact on fetal and neonatal development, especially as obesity rates are on the rise worldwide. Together, these findings reveal enduring effects of maternal diet on offspring, support the findings on the effects of neonatal inflammation on anxiety-like behaviors in later-life periods, and add to the complex relationship between gestational and neonatal inflammation and anxiety.
[Mh] Termos MeSH primário: Ansiedade
Comportamento Animal/efeitos dos fármacos
Carboidratos da Dieta/efeitos adversos
Frutose/efeitos adversos
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Animais
Ansiedade/induzido quimicamente
Ansiedade/fisiopatologia
Carboidratos da Dieta/farmacologia
Feminino
Frutose/farmacologia
Inflamação/induzido quimicamente
Inflamação/patologia
Inflamação/fisiopatologia
Lipopolissacarídeos/toxicidade
Memória/efeitos dos fármacos
Gravidez
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Efeitos Tardios da Exposição Pré-Natal/patologia
Efeitos Tardios da Exposição Pré-Natal/fisiopatologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Lipopolysaccharides); 30237-26-4 (Fructose)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


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[PMID]:29197622
[Au] Autor:Qiao Y; Xu L; Tao X; Yin L; Qi Y; Xu Y; Han X; Tang Z; Ma X; Liu K; Peng J
[Ad] Endereço:College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian 116044, China.
[Ti] Título:Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
[So] Source:Toxicol Lett;284:37-45, 2018 Mar 01.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In the present work, the effects and possible mechanisms of dioscin, one natural product from the famous vegetable Dioscoreae rhizoma (Shanyao in Chinese), against high fructose-induced renal injury in rats were tested. The results showed that dioscin significantly restored fructose-induced renal injury by decreasing the levels of Cr, BUN, and rehabilitating histopathological changes. In addition, dioscin markedly adjusted the levels of MDA, SOD and GSH-Px, reduced ROS level in renal tissue, and decreased the levels of TG, FFA, α-SMA and COL1A. Mechanistic study showed that dioscin significantly up-regulated the expression levels of Sirt3, SOD2, and then suppressed inflammation by decreasing the expression levels of NF-kB, HMGB1, c-Jun, c-Fos, COX2, TNF-α, IL-1ß and IL-6. Furthermore, dioscin-caused high levels of Sirt3 and SOD2 attenuated oxidative stress by regulating the expression levels of Nrf2, GST, Keap1, regulated lipid metabolism by controlling the expression levels of SREBP-1c, SCD-1, FASn, ACC, CPT1, and adjusted TGF-ß1/Smad signal to inhibit renal fibrosis. In summary, dioscin showed protective effects against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, renal fibrosis, lipid metabolism and inflammation, which should be considered as one candidate to treat renal injury in the future. We also suggest that the patients with renal injury can take more Shanyao for the therapy and treatment.
[Mh] Termos MeSH primário: Diosgenina/análogos & derivados
Rim/efeitos dos fármacos
Rim/patologia
Metabolismo dos Lipídeos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Diosgenina/farmacologia
Modelos Animais de Doenças
Fibrose
Frutose
Inflamação
Masculino
Ratos Sprague-Dawley
Insuficiência Renal Crônica/metabolismo
Insuficiência Renal Crônica/patologia
Insuficiência Renal Crônica/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protective Agents); 30237-26-4 (Fructose); 3B95U4OLWV (dioscin); K49P2K8WLX (Diosgenin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE


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[PMID]:28458081
[Au] Autor:van Putten RJ; van der Waal JC; de Jong E; Heeres HJ
[Ad] Endereço:Avantium Chemicals B.V., Zekeringstraat 29, 1014 BV Amsterdam, The Netherlands. Electronic address: robert-jan.vanputten@avantium.com.
[Ti] Título:Reactivity studies in water on the acid-catalysed dehydration of psicose compared to other ketohexoses into 5-hydroxymethylfurfural.
[So] Source:Carbohydr Res;446-447:1-6, 2017 Jun 29.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The conversion of the four possible ketohexoses (fructose, tagatose, sorbose and psicose) into 5-hydroxymethylfurfural (HMF) was explored in water using sulphuric acid as the catalyst (33 mM H SO , 120 °C). Significant differences in reactivity were observed and tagatose (48% conversion after 75 min) and psicose (35% conversion after 75 min) were clearly more reactive than fructose and sorbose (around 20% conversion after 75 min). The selectivity to HMF was found to be higher for fructose and psicose than for tagatose and sorbose. 2-Hydroxyacetylfuran (HAF) was shown to be a by-product for mainly sorbose and tagatose (as high as 2% yield). The results indicate that the relative orientation of the hydroxyl groups on C3 and C4 has a major effect on the reactivity and selectivity. This suggests that the dehydration towards HMF takes place via a mechanism with cyclic intermediates in which the C3C4 bond is fixed in a ring structure. A reaction mechanism involving a bicyclic structure is proposed to explain the formation of HAF. The reactivity of the sugars was significantly lower in water than previously observed in methanol.
[Mh] Termos MeSH primário: Frutose/química
Furaldeído/análogos & derivados
Água/química
[Mh] Termos MeSH secundário: Catálise
Furaldeído/química
Concentração de Íons de Hidrogênio
Metanol/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 23140-52-5 (psicose); 30237-26-4 (Fructose); 70ETD81LF0 (5-hydroxymethylfurfural); DJ1HGI319P (Furaldehyde); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29376304
[Au] Autor:Apryatin SA; Mzhelskaya KV; Trusov NV; Balakina AS; Kulakova SN; Soto SK; Makarenko MA; Riger NA; Tutelyan VA
[Ti] Título:[Comparative characteristics of in vivo models of hyperlipidemia in Wistar rats and C57Bl/6 mice].
[So] Source:Vopr Pitan;85(6):14-23, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In vivo simulation of lipid disorders (hyperlipidemia, obesity, metabolic syndrome, atherosclerosis) is of considerable interest to search for genomic, transcriptomic and metabolomic markers that allow for differential diagnosis, prognosis and selection of personalized diet therapy in patients with such pathology. The aim of the study was the development and characterization of basic biochemical parameters of in vivo models of alimentary hyperlipidemia in outbred rats and inbred mice. The experiment was con­ducted on 48 growing female Wistar rats, and 48 growing female mice of line C57Black/6, which were divided into 12 groups of 8 animals per group. Within 63 days the rats and mice of first (control) group received a balanced semi synthetic diet (BD), the animals of the second groups - high-fat diet (HFD) with 30% of the total fat by weight of dry feed, third groups - BD and fructose solution (Fr) instead of water, the fourth groups -HFD + Fr, fifth groups - BD supplemented with 0.5% cholesterol (Cho) by weight of dry feed, sixth groups - BD with Cho and Fr. The amount and composition of diets consumed were corrected during the experiment for their closest approach in calories. After removal of animals from the experiment there were determined the mass of internal organs, HDL, LDL, total cholesterol, triglycerides, glucose in blood plasma, total lipids and their fatty acid composition in liver, ghrelin, GIP, GLP-1, glucagon, leptin, PAI-1, resistin levels in blood plasma. It was found that in both species the liver is the most sensitive to nutritional imbalance, nutrient exerting the greatest impact on this was Fr. In rats, as compared to mice, there was significantly more pronounced shifts in lipoprotein spectrum in response to nutritional imbalances, especially to the consumption of additional Cho, which was manifested in an increase of LDL, decrease of HDL and magnification of atherogenic index. In the liver of rats fed diets with Cho, marked steatosis developed manifested in a disproportionate increase in the lipid content and accompanied by changes in their fatty acid composition, especially in the ratio ω6 to ω3 PUFAs. Changing of hormones - regula­tors of carbohydrate metabolism (GLP, glucagon) and ghrelin was significantly greater in mice than in rats as a result of consumption of additional Fr. Effect had the opposite direction in two species of Cho and Fr combining on leptin levels. The significance is dis­cussed of the revealed interspecies differences in the light of the characteristics of lipid and glucose metabolism in these two lines of animals that are the most common models of alimentary-dependent diseases.
[Mh] Termos MeSH primário: Carboidratos da Dieta/efeitos adversos
Gorduras na Dieta/efeitos adversos
Modelos Animais de Doenças
Frutose/efeitos adversos
Hiperlipidemias
[Mh] Termos MeSH secundário: Animais
Carboidratos da Dieta/farmacologia
Gorduras na Dieta/farmacologia
Feminino
Frutose/farmacologia
Hiperlipidemias/sangue
Hiperlipidemias/induzido quimicamente
Hiperlipidemias/patologia
Camundongos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates); 0 (Dietary Fats); 30237-26-4 (Fructose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:29334926
[Au] Autor:Ghelani H; Razmovski-Naumovski V; Pragada RR; Nammi S
[Ad] Endereço:School of Science and Health, Western Sydney University, Sydney, NSW, 2751, Australia.
[Ti] Título:(R)-α-Lipoic acid inhibits fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro.
[So] Source:BMC Complement Altern Med;18(1):13, 2018 Jan 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objective of the present study is to evaluate the protective effect of (R)-α-lipoic acid (ALA) against fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro. METHODS: The anti-glycation activity of ALA was determined using the formation of AGEs fluorescence intensity, iron released from the heme moiety of myoglobin and the level of fructosamine. The fructation-induced myoglobin oxidation was examined using the level of protein carbonyl content and thiol group estimation. RESULTS: The results showed that co-incubation of myoglobin (1 mg/mL), fructose (1 M) and ALA (1, 2 and 4 mM) significantly inhibited the formation of AGEs during the 30 day study period. ALA markedly decreased the levels of fructosamine, which is directly associated with the reduction of AGEs formation. Furthermore, ALA significantly reduced free iron release from myoglobin which is attributed to the protection of myoglobin from fructose-induced glycation. The results also demonstrated a significant protective effect of ALA on myoglobin oxidative damages, as seen from decreased protein carbonyl content and increased protein thiols. CONCLUSION: These findings provide new insights into the anti-glycation properties of ALA and emphasize that ALA supplementation is beneficial in the prevention of AGEs-mediated diabetic and cardiovascular complications.
[Mh] Termos MeSH primário: Frutose/metabolismo
Produtos Finais de Glicação Avançada/metabolismo
Glicosilação/efeitos dos fármacos
Mioglobina/metabolismo
Ácido Tióctico/farmacologia
[Mh] Termos MeSH secundário: Animais
Produtos Finais de Glicação Avançada/análise
Mioglobina/análise
Mioglobina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycation End Products, Advanced); 0 (Myoglobin); 30237-26-4 (Fructose); 73Y7P0K73Y (Thioctic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2076-6


  6 / 14209 MEDLINE  
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[PMID]:29194737
[Au] Autor:Takada T; Sasaki T; Sato R; Kikuta S; Inoue MN
[Ad] Endereço:Graduate School of Bio-Applications and Systems Engineering (BASE), Tokyo University of Agriculture and Technology, Koganei, Japan.
[Ti] Título:Differential expression of a fructose receptor gene in honey bee workers according to age and behavioral role.
[So] Source:Arch Insect Biochem Physiol;97(2), 2018 Feb.
[Is] ISSN:1520-6327
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Honey bee (Apis mellifera) workers contribute to the maintenance of colonies in various ways. The primary functions of workers are divided into two types depending on age: young workers (nurses) primarily engage in such behaviors as cleaning and food handling within the hive, whereas older workers (foragers) acquire floral nutrients beyond the colony. Concomitant with this age-dependent change in activity, physiological changes occur in the tissues and organs of workers. Nurses supply younger larvae with honey containing high levels of glucose and supply older larvae with honey containing high levels of fructose. Given that nurses must determine both the concentration and type of sugar used in honey, gustatory receptors (Gr) expressed in the chemosensory organs likely play a role in distinguishing between sugars. Glucose is recognized by Gr1 in honey bees (AmGr1); however, it remains unclear which Gr are responsible for fructose recognition. This study aimed to identify fructose receptors in honey bees and reported that AmGr3, when transiently expressed in Xenopus oocytes, responded only to fructose, and to no other sugars. We analyzed expression levels of AmGr3 to identify which tissues and organs of workers are involved in fructose recognition and determined that expression of AmGr3 was particularly high in the antennae and legs of nurses. Our results suggest that nurses use their antennae and legs to recognize fructose, and that AmGr3 functions as an accurate nutrient sensor used to maintain food quality in honey bee hives.
[Mh] Termos MeSH primário: Antenas de Artrópodes/metabolismo
Abelhas/metabolismo
Frutose/metabolismo
Proteínas de Insetos/metabolismo
Receptores de Superfície Celular/metabolismo
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Abelhas/genética
Comportamento Animal
Xenopus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Proteins); 0 (Receptors, Cell Surface); 30237-26-4 (Fructose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1002/arch.21437


  7 / 14209 MEDLINE  
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[PMID]:29364598
[Au] Autor:Doronina NV; Kaparulina EN; Trotsenko YA
[Ti] Título:Emended Description of Methylovorus glucosotrophus Govorukhina and Trotsenko 1991.
[So] Source:Mikrobiologiia;85(5):506-511, 2016 Sep.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Phylogeneticanalysis based,on comparison of the 16S rRNA gene sequences in combination with comparative analysis of physiological, biochemical, and chemotaxonomic characteristics and DNA-DNA hybridization revealed that "Methylobacillusfructoseoxidans" 34 (VKM B-1609 = DSM 5897 and-Methylov- orus glucosotrophus 6B 1T (ATCC 49758T = DSM 6874T = VKM B- 1745T = NCIMB 13222 ) belong to the same Methylovorus species. Extended description of the limited facultative methylotroph Methylovorus gluco- sotrophus is proposed, which includes the fructose-utilizing strain 34. Emended description of Methylovorus glucosotrophus is provided.
[Mh] Termos MeSH primário: DNA Bacteriano/genética
Frutose/metabolismo
Metanol/metabolismo
Methylophilaceae/classificação
Filogenia
RNA Ribossômico 16S/genética
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Meios de Cultura/química
Meios de Cultura/farmacologia
Ácidos Graxos/química
Ácidos Graxos/isolamento & purificação
Frutose/farmacologia
Redes e Vias Metabólicas/genética
Metanol/farmacologia
Methylophilaceae/efeitos dos fármacos
Methylophilaceae/genética
Methylophilaceae/metabolismo
Fosfolipídeos/química
Fosfolipídeos/isolamento & purificação
Federação Russa
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 30237-26-4 (Fructose); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:29324859
[Au] Autor:He D; Mustafi D; Fan X; Fernandez S; Markiewicz E; Zamora M; Mueller J; Sachleben JR; Brady MJ; Conzen SD; Karczmar GS
[Ad] Endereço:Department of Radiology, The University of Chicago, Chicago, Illinois, United States of America.
[Ti] Título:Magnetic resonance spectroscopy detects differential lipid composition in mammary glands on low fat, high animal fat versus high fructose diets.
[So] Source:PLoS One;13(1):e0190929, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of consumption of different diets on the fatty acid composition in the mammary glands of SV40 T-antigen (Tag) transgenic mice, a well-established model of human triple-negative breast cancer, were investigated with magnetic resonance spectroscopy and spectroscopic imaging. Female C3(1) SV40 Tag transgenic mice (n = 12) were divided into three groups at 4 weeks of age: low fat diet (LFD), high animal fat diet (HAFD), and high fructose diet (HFruD). MRI scans of mammary glands were acquired with a 9.4 T scanner after 8 weeks on the diet. 1H spectra were acquired using point resolved spectroscopy (PRESS) from two 1 mm3 boxes on each side of inguinal mammary gland with no cancers, lymph nodes, or lymph ducts. High spectral and spatial resolution (HiSS) images were also acquired from nine 1-mm slices. A combination of Gaussian and Lorentzian functions was used to fit the spectra. The percentages of poly-unsaturated fatty acids (PUFA), mono-unsaturated fatty acids (MUFA), and saturated fatty acids (SFA) were calculated from each fitted spectrum. Water and fat peak height images (maps) were generated from HiSS data. The results showed that HAFD mice had significantly lower PUFA than both LFD (p < 0.001) and HFruD (p < 0.01) mice. The mammary lipid quantity calculated from 1H spectra was much larger in HAFD mice than in LFD (p = 0.03) but similar to HFruD mice (p = 0.10). The average fat signal intensity over the mammary glands calculated from HiSS fat maps was ~60% higher in HAFD mice than in LFD (p = 0.04) mice. The mean or median of calculated parameters for the HFruD mice were between those for LFD and HAFD mice. Therefore, PRESS spectroscopy and HiSS MRI demonstrated water and fat composition changes in mammary glands due to a Western diet, which was low in potassium, high in sodium, animal fat, and simple carbohydrates. Measurements of PUFA with MRI could be used to evaluate cancer risk, improve cancer detection and diagnosis, and guide preventative therapy.
[Mh] Termos MeSH primário: Dieta com Restrição de Gorduras
Dieta Hiperlipídica
Açúcares da Dieta
Ácidos Graxos/metabolismo
Glândulas Mamárias Animais/metabolismo
Espectroscopia de Prótons por Ressonância Magnética
[Mh] Termos MeSH secundário: Animais
Feminino
Frutose
Imagem por Ressonância Magnética
Glândulas Mamárias Animais/diagnóstico por imagem
Camundongos Transgênicos
Distribuição Aleatória
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Sugars); 0 (Fatty Acids); 30237-26-4 (Fructose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190929


  9 / 14209 MEDLINE  
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[PMID]:29232127
[Au] Autor:Wu J; Sabag-Daigle A; Metz TO; Deatherage Kaiser BL; Gopalan V; Behrman EJ; Wysocki VH; Ahmer BMM
[Ad] Endereço:Department of Chemistry and Biochemistry, The Ohio State University , Columbus, Ohio 43210, United States.
[Ti] Título:Measurement of Fructose-Asparagine Concentrations in Human and Animal Foods.
[So] Source:J Agric Food Chem;66(1):212-217, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The food-borne bacterial pathogen, Salmonella enterica, can utilize fructose-asparagine (F-Asn) as its sole carbon and nitrogen source. F-Asn is the product of an Amadori rearrangement following the nonenzymatic condensation of glucose and asparagine. Heating converts F-Asn via complex Maillard reactions to a variety of molecules that contribute to the color, taste, and aroma of heated foods. Among these end derivatives is acrylamide, which is present in some foods, especially in fried potatoes. The F-Asn utilization pathway in Salmonella, specifically FraB, is a potential drug target because inhibition of this enzyme would lead to intoxication of Salmonella in the presence of F-Asn. However, F-Asn would need to be packaged with the FraB inhibitor or available in human foods. To determine if there are foods that have sufficient F-Asn, we measured F-Asn concentrations in a variety of human and animal foods. The 400 pmol/mg F-Asn found in mouse chow is sufficient to intoxicate a Salmonella fraB mutant in mouse models of salmonellosis, and several human foods were found to have F-Asn at this level or higher (fresh apricots, lettuce, asparagus, and canned peaches). Much higher concentrations (11 000-35 000 pmol/mg dry weight) were found in heat-dried apricots, apples, and asparagus. This report reveals possible origins of F-Asn as a nutrient source for Salmonella and identifies foods that could be used together with a FraB inhibitor as a therapeutic agent for Salmonella.
[Mh] Termos MeSH primário: Ração Animal/análise
Asparagina/análise
Asparagus (Planta)/química
Frutose/análise
Malus/química
Prunus armeniaca/química
Solanum tuberosum/química
[Mh] Termos MeSH secundário: Animais
Asparagus (Planta)/microbiologia
Temperatura Alta
Seres Humanos
Reação de Maillard
Malus/microbiologia
Prunus armeniaca/microbiologia
Salmonella enterica/genética
Salmonella enterica/metabolismo
Solanum tuberosum/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
30237-26-4 (Fructose); 7006-34-0 (Asparagine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04237


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[PMID]:29176325
[Au] Autor:Dibué-Adjei M; Kamp MA; Alpdogan S; Tevoufouet EE; Neiss WF; Hescheler J; Schneider T
[Ad] Endereço:Institute for Neurophysiology, Cologne, Germany.
[Ti] Título:Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo.
[So] Source:Cell Physiol Biochem;44(3):935-947, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Lamotrigine (LTG) is a popular modern antiepileptic drug (AED), however, its mechanism of action has yet to be fully understood, as it is known to modulate many members of several ion channel families. In heterologous systems, LTG inhibits Cav2.3 (R-type) calcium currents, which contribute to kainic-acid- (KA) induced epilepsy in vivo. To gain insight into the role of R-type currents in LTG drug action in vivo, we compared the effects of LTG to topiramate and lacosamide in Cav2.3-deficient mice and controls on KA-induced seizures. METHODS: Behavioral seizure rating and quantitative electrocorticography were performed after injection of 20 mg/kg [and 30 mg/kg] KA. One hour before KA injection, mice were pretreated with either 30 mg/kg LTG, 50 mg/kg topiramate (TPM) or 30 mg/kg lacosamide (LSM). RESULTS: Ablation of Cav2.3 reduced total seizure scores by 28.6% (p=0.0012) and pretreatment with LTG reduced seizure activity of control mice by 23.2% (p=0.02). In Cav2.3-deficient mice LTG pretreatment increased seizure activity by 22.1% (p=0.018) and increased the percentage of degenerated CA1 pyramidal neurons (p=0.02). All three tested AEDs reduced seizure activity in control mice, however only the non-calcium channel modulating AED, LSM had an anticonvulsive effect in Cav2.3-deficient mice. Furthermore LTG altered electrocorticographic parameters differently in the two genotypes, decreasing relative power of ictal spikes in control mice compared to Cav2.3-defcient mice. CONCLUSION: These findings give first in vivo evidence for an essential role for Cav2.3 in LTG pharmacology and shed light on a paradoxical effect of LTG in their absence. Furthermore, LTG appears to promote ictal activity in Cav2.3-deficient mice resulting in increased neurotoxicity in the CA1 region. This paradoxical mechanism, possibly reflecting rebound hyperexcitation of pyramidal CA1 neurons after increased inhibition, may be key in understanding LTG-induced seizure aggravation, observed in clinical practice.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Comportamento Animal/efeitos dos fármacos
Canais de Cálcio Tipo R/genética
Epilepsia/patologia
Fármacos Neuroprotetores/farmacologia
Triazinas/farmacologia
[Mh] Termos MeSH secundário: Acetamidas/farmacologia
Acetamidas/uso terapêutico
Animais
Anticonvulsivantes/uso terapêutico
Canais de Cálcio Tipo R/deficiência
Eletrocorticografia
Epilepsia/induzido quimicamente
Epilepsia/prevenção & controle
Frutose/análogos & derivados
Frutose/farmacologia
Frutose/uso terapêutico
Genótipo
Imuno-Histoquímica
Ácido Caínico/toxicidade
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fármacos Neuroprotetores/uso terapêutico
Células Piramidais/efeitos dos fármacos
Células Piramidais/patologia
Triazinas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetamides); 0 (Anticonvulsants); 0 (Calcium Channels, R-Type); 0 (Neuroprotective Agents); 0 (Triazines); 0H73WJJ391 (topiramate); 30237-26-4 (Fructose); 563KS2PQY5 (lacosamide); SIV03811UC (Kainic Acid); U3H27498KS (lamotrigine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1159/000485361



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