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[PMID]:29327928
[Au] Autor:Zhu ZJ; Chen HM; Chen JJ; Yang R; Yan XJ
[Ad] Endereço:Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo, Zhejiang 315211, China.
[Ti] Título:One-Step Bioconversion of Fatty Acids into C8-C9 Volatile Aroma Compounds by a Multifunctional Lipoxygenase Cloned from Pyropia haitanensis.
[So] Source:J Agric Food Chem;66(5):1233-1241, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The multifunctional lipoxygenase PhLOX cloned from Pyropia haitanensis was expressed in Escherichia coli with 24.4 mg·L yield. PhLOX could catalyze the one-step bioconversion of C18-C22 fatty acids into C8-C9 volatile organic compounds (VOCs), displaying higher catalytic efficiency for eicosenoic and docosenoic acids than for octadecenoic acids. C20:5 was the most suitable substrate among the tested fatty acids. The C8-C9 VOCs were generated in good yields from fatty acids, e.g., 2E-nonenal from C20:4, and 2E,6Z-nonadienal from C20:5. Hydrolyzed oils were also tested as substrates. The reactions mainly generated 2E,4E-pentadienal, 2E-octenal, and 2E,4E-octadienal from hydrolyzed sunflower seed oil, corn oil, and fish oil, respectively. PhLOX showed good stability after storage at 4 °C for 2 weeks and broad tolerance to pH and temperature. These desirable properties of PhLOX make it a promising novel biocatalyst for the industrial production of volatile aroma compounds.
[Mh] Termos MeSH primário: Ácidos Graxos/metabolismo
Lipoxigenase/genética
Lipoxigenase/metabolismo
Proteínas Recombinantes/metabolismo
Rodófitas/enzimologia
Compostos Orgânicos Voláteis/metabolismo
[Mh] Termos MeSH secundário: Clonagem Molecular
Óleo de Milho/metabolismo
Estabilidade Enzimática
Ácidos Erúcicos/metabolismo
Escherichia coli/genética
Ácidos Graxos Monoinsaturados/metabolismo
Óleos de Peixe/metabolismo
Expressão Gênica
Concentração de Íons de Hidrogênio
Rodófitas/genética
Especificidade por Substrato
Óleo de Girassol/metabolismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Erucic Acids); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Fish Oils); 0 (Recombinant Proteins); 0 (Sunflower Oil); 0 (Volatile Organic Compounds); 8001-30-7 (Corn Oil); EC 1.13.11.12 (Lipoxygenase); UDX6WPL94T (eicosenoic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05341


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[PMID]:28380579
[Au] Autor:Hales KE; Foote AP; Brown-Brandl TM; Freetly HC
[Ti] Título:The effects of feeding increasing concentrations of corn oil on energy metabolism and nutrient balance in finishing beef steers.
[So] Source:J Anim Sci;95(2):939-948, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of an added lipid is common in high-concentrate finishing diets. The objective of our experiment was to determine if feeding increasing concentrations of added dietary corn oil would decrease enteric methane production, increase the ME:DE ratio, and improve recovered energy (RE) in finishing beef steers. Four treatments were used in a replicated 4 × 4 Latin square ( = 8; initial BW = 397 kg ± 3.8). Data were analyzed using a Mixed model with the fixed effects of period and dietary treatment and random effects of square and steer within square. Treatments consisted of: (1) 0% added corn oil (Fat-0); (2) 2% added corn oil (Fat-2); (3) 4% added corn oil (Fat-4); (4) 6% added corn oil (Fat-6). Dry matter intake or GE intake did not differ across diets ( ≥ 0.39). As a proportion of GE intake, fecal energy loss, DE, and urinary energy loss did not differ by treatment ( ≥ 0.27). Additionally, methane energy produced decreased linearly as corn oil increased in the diet ( < 0.01). No differences were detected in ME loss as a proportion of GE intake ( ≥ 0.98). However, the ME:DE ratio increased linearly ( < 0.01; 93.06, 94.10, 94.64, and 95.20 for Fat-0, Fat-2, Fat-4, and Fat-6, respectively) as corn oil inclusion increased in the diet. No differences in RE or heat production as a proportion of GE intake were noted ( ≥ 0.59) and dry matter digestibility did not differ across diets ( ≥ 0.36). Digestibility of NDF as a proportion of intake responded quadratically increasing from 0% corn to 4% corn oil and decreasing thereafter ( = 0.02). Furthermore, ether extract digestibility as a proportion of intake responded quadratically, increasing from 0% to 4% corn oil inclusion before reaching a plateau ( < 0.01). As a proportion of GE intake, RE as protein decreased linearly as corn oil was increased in the diet ( < 0.01). As a proportion of total energy retained, RE as protein decreased when corn oil increased from 0% to 6% of diet DM ( < 0.01). Similarly, RE as fat and carbohydrate as a proportion of GE intake increased linearly as corn oil increased in the diet ( = 0.05). From these data, we interpret that adding dietary fat decreases enteric methane production and increases the ME:DE ratio, in addition to increasing the amount of energy retained as fat and carbohydrate.
[Mh] Termos MeSH primário: Ração Animal/análise
Óleo de Milho/farmacologia
Dieta/veterinária
Metabolismo Energético/efeitos dos fármacos
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal
Animais
Bovinos
Óleo de Milho/administração & dosagem
Gorduras na Dieta/metabolismo
Digestão
Relação Dose-Resposta a Droga
Fezes
Masculino
Metano/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Fats); 8001-30-7 (Corn Oil); OP0UW79H66 (Methane)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.0902


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[PMID]:28333981
[Au] Autor:Wu C; Evans CE; Dai Z; Huang X; Zhang X; Jin H; Hu G; Song Y; Zhao YY
[Ad] Endereço:Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois, United States of America.
[Ti] Título:Lipopolysaccharide-induced endotoxemia in corn oil-preloaded mice causes an extended course of lung injury and repair and pulmonary fibrosis: A translational mouse model of acute respiratory distress syndrome.
[So] Source:PLoS One;12(3):e0174327, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia respiratory failure, bilateral pulmonary infiltrates, and pulmonary edema of non-cardiac origin. Effective treatments for ARDS patients may arise from experimental studies with translational mouse models of this disease that aim to delineate the mechanisms underlying the disease pathogenesis. Mouse models of ARDS, however, can be limited by their rapid progression from injured to recovery state, which is in contrast to the course of ARDS in humans. Furthermore, current mouse models of ARDS do not recapitulate certain prominent aspects of the pathogenesis of ARDS in humans. In this study, we developed an improved endotoxemic mouse model of ARDS resembling many features of clinical ARDS including extended courses of injury and recovery as well as development of fibrosis following i.p. injection of lipopolysaccharide (LPS) to corn oil-preloaded mice. Compared with mice receiving LPS alone, those receiving corn oil and LPS exhibited extended course of lung injury and repair that occurred over a period of >2 weeks instead of 3-5days. Importantly, LPS challenge of corn oil-preloaded mice resulted in pulmonary fibrosis during the repair phase as often seen in ARDS patients. In summary, this simple novel mouse model of ARDS could represent a valuable experimental tool to elucidate mechanisms that regulate lung injury and repair in ARDS patients.
[Mh] Termos MeSH primário: Endotoxemia/etiologia
Lipopolissacarídeos/farmacologia
Lesão Pulmonar/induzido quimicamente
Fibrose Pulmonar/induzido quimicamente
Síndrome do Desconforto Respiratório do Adulto/etiologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Óleo de Milho/farmacologia
Modelos Animais de Doenças
Endotoxemia/complicações
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 8001-30-7 (Corn Oil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174327


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[PMID]:28324023
[Au] Autor:Sankoda A; Harada N; Iwasaki K; Yamane S; Murata Y; Shibue K; Thewjitcharoen Y; Suzuki K; Harada T; Kanemaru Y; Shimazu-Kuwahara S; Hirasawa A; Inagaki N
[Ad] Endereço:Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
[Ti] Título:Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice.
[So] Source:Endocrinology;158(5):1172-1180, 2017 May 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Free fatty acid receptors GPR120 and GPR40 are involved in the secretion of gut hormones. GPR120 and GPR40 are expressed in enteroendocrine K cells, and their activation induces the secretion of the incretin glucose-dependent insulinotropic polypeptide (GIP). However, the role of these receptors in fat-induced GIP secretion in vivo and the associated mechanisms are unclear. In this study, we investigated corn oil-induced GIP secretion in GPR120-knockout (GPR120-/-) and GPR40-knockout (GPR40-/-) mice. Oil-induced GIP secretion was reduced by 50% and 80% in GPR120-/- and GPR40-/- mice, respectively, compared with wild-type mice. This was not associated with a significant difference in K-cell number or GIP content in K cells, nor messenger RNA levels of the lipid receptor GPR119, nor bile acid receptors TGR5 and farnesoid X receptor. GPR120-/- and GPR40-/- mice also exhibited substantially decreased levels of cholecystokinin (CCK), a hormone from I cells that promotes bile and pancreatic lipase secretion, and this decrease was associated with impaired gallbladder contraction. Notably, treatment with a CCK analog resulted in recovery of oil-induced GIP secretion in GPR120-/- mice but not in GPR40-/- mice. These results indicate that corn oil-induced GIP secretion from K cells involves both GPR120 and GPR40 signaling pathways, and GPR120-induced GIP secretion is indirectly mediated by CCK.
[Mh] Termos MeSH primário: Colecistocinina/metabolismo
Óleo de Milho/farmacologia
Polipeptídeo Inibidor Gástrico/secreção
Receptores Acoplados a Proteínas-G/fisiologia
[Mh] Termos MeSH secundário: Animais
Gorduras na Dieta/farmacologia
Células Enteroendócrinas/efeitos dos fármacos
Células Enteroendócrinas/secreção
Ácidos Graxos não Esterificados/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Receptores Acoplados a Proteínas-G/genética
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids, Nonesterified); 0 (Gpr40 protein, mouse); 0 (O3far1 protein, mouse); 0 (Receptors, G-Protein-Coupled); 59392-49-3 (Gastric Inhibitory Polypeptide); 8001-30-7 (Corn Oil); 9011-97-6 (Cholecystokinin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00090


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[PMID]:28317713
[Au] Autor:de Andrade JK; de Andrade CK; Komatsu E; Perreault H; Torres YR; da Rosa MR; Felsner ML
[Ad] Endereço:Departamento de Química, Universidade Estadual do Centro-Oeste - UNICENTRO, 85040-080 Guarapuava, PR, Brazil. Electronic address: jucimarakulekdeandrade@gmail.com.
[Ti] Título:A validated fast difference spectrophotometric method for 5-hydroxymethyl-2-furfural (HMF) determination in corn syrups.
[So] Source:Food Chem;228:197-203, 2017 Aug 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Corn syrups, important ingredients used in food and beverage industries, often contain high levels of 5-hydroxymethyl-2-furfural (HMF), a toxic contaminant. In this work, an in house validation of a difference spectrophotometric method for HMF analysis in corn syrups was developed using sophisticated statistical tools by the first time. The methodology showed excellent analytical performance with good selectivity, linearity (R =99.9%, r>0.99), accuracy and low limits (LOD=0.10mgL and LOQ=0.34mgL ). An excellent precision was confirmed by repeatability (RSD (%)=0.30) and intermediate precision (RSD (%)=0.36) estimates and by Horrat value (0.07). A detailed study of method precision using a nested design demonstrated that variation sources such as instruments, operators and time did not interfere in the variability of results within laboratory and consequently in its intermediate precision. The developed method is environmentally friendly, fast, cheap and easy to implement resulting in an attractive alternative for corn syrups quality control in industries and official laboratories.
[Mh] Termos MeSH primário: Óleo de Milho/análise
Furaldeído/análogos & derivados
Xarope de Milho Rico em Frutose/química
Espectrofotometria/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos
Furaldeído/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (High Fructose Corn Syrup); 70ETD81LF0 (5-hydroxymethylfurfural); 8001-30-7 (Corn Oil); DJ1HGI319P (Furaldehyde)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28299528
[Au] Autor:Muhlenbeck JA; Butz DE; Olson JM; Uribe-Cano D; Cook ME
[Ad] Endereço:Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI, 53706, USA.
[Ti] Título:Dietary Conjugated Linoleic Acid-c9t11 Prevents Collagen-Induced Arthritis, Whereas Conjugated Linoleic Acid-t10c12 Increases Arthritic Severity.
[So] Source:Lipids;52(4):303-314, 2017 Apr.
[Is] ISSN:1558-9307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Two conjugated linoleic acid (CLA) isomers, cis-9, trans-11 (CLAc9t11) and trans-10, cis-12 (CLAt10c12), reduce inflammation in a number of animal models, including collagen-induced arthritis (CA). However, little is known about the ability of individual CLA isomers to prevent autoimmune disease onset. Evidence that mixed isomer CLA drives T helper cell (Th) 1 responses suggests that CLA, or a specific isomer, exacerbates onset of Th1 autoimmune diseases. In two experiments, we examined if prior dietary exposure to CLAt10c12 (experiment 1) or CLAc9t11 (experiment 2) affected the incidence or severity of CA. DBA/1 mice were fed a semi purified diet with either 6% corn oil (CO, w/w), 5.75% CO plus 0.25% CLAt10c12, or 5.5% CO plus 0.5% CLAc9t11 prior to arthritis development. Arthritis incidence and severity, anti-collagen antibodies, paw cytokines, and hepatic fatty acids were measured. CLAt10c12 had no effect on arthritis incidence but increased arthritic severity (42%, P = 0.02); however, CLAc9t11 decreased arthritis incidence 39% compared to CO fed mice (P = 0.01), but had no effect on disease severity. CLAt10c12-induced increase in anti-collagen type II IgG antibodies may be a mechanism by which this isomer increased arthritic severity, and CLAc9t11-induced increase in Th2 paw cytokines (IL-4 and IL-10, P ≤ 0.04) may explain how CLAc9t11 reduced the arthritis incidence. While both isomers are well known to reduce inflammation in arthritic mice, these new data suggest isomer differences when fed prior to autoimmune disease.
[Mh] Termos MeSH primário: Artrite Experimental/epidemiologia
Óleo de Milho/administração & dosagem
Gorduras na Dieta/administração & dosagem
Ácidos Linoleicos Conjugados/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/imunologia
Artrite Experimental/prevenção & controle
Óleo de Milho/farmacologia
Citocinas/metabolismo
Gorduras na Dieta/farmacologia
Quimioterapia Combinada
Ácidos Linoleicos Conjugados/farmacologia
Camundongos
Camundongos Endogâmicos DBA
Distribuição Aleatória
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Dietary Fats); 0 (Linoleic Acids, Conjugated); 0 (trans-10,cis-12-conjugated linoleic acid); 1839-11-8 (9,11-linoleic acid); 8001-30-7 (Corn Oil)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1007/s11745-017-4241-6


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[PMID]:28188800
[Au] Autor:Chen X; He X; Fu X; Zhang B; Huang Q
[Ad] Endereço:School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, PR China.
[Ti] Título:Complexation of rice starch/flour and maize oil through heat moisture treatment: Structural, in vitro digestion and physicochemical properties.
[So] Source:Int J Biol Macromol;98:557-564, 2017 May.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study investigated structural, in vitro digestion and physicochemical properties of normal rice starch (NRS)/flour (NRF) complexed with maize oil (MO) through heat-moisture treatment (HMT). The NRS-/NRF-MO complex displayed an increased pasting temperature and a decreased peak viscosity. After HMT, less ordered Maltese and more granule fragments were observed for NRS-/NRF-MO complex. Meanwhile, more aggregation was observed in the HMT samples with higher moisture contents. We found that higher onset temperature, lower enthalpy change and relative crystallinity of the NRS-/NRF-MO complex were associated with a higher moisture content of HMT samples. The higher moisture content of HMT was also favorable for the amylose-lipid complex formation. Differences in starch digestion properties were found for NRS-MO and NRF-MO complex. All of the NRS/NRF complexed MO after cooking showed lower rapidly digestible starch (RDS) contents compared with the control sample, therein NRS-/NRF- MO exhibited the highest sum of the slowly digestible starch and resistant starch contents. In general, HMT had a greater impact on the in vitro digestion and physicochemical properties of flour samples compared with starch counterparts.
[Mh] Termos MeSH primário: Culinária
Óleo de Milho/química
Amido/química
[Mh] Termos MeSH secundário: Amilose/química
Farinha
Temperatura Alta
Oryza/química
Termodinâmica
Viscosidade
Água/química
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 8001-30-7 (Corn Oil); 9005-25-8 (Starch); 9005-82-7 (Amylose)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


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[PMID]:28177390
[Au] Autor:Lindblom SC; Dozier WA; Shurson GC; Kerr BJ
[Ti] Título:Digestibility of energy and lipids and oxidative stress in nursery pigs fed commercially available lipids.
[So] Source:J Anim Sci;95(1):239-247, 2017 Jan.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An experiment was conducted to evaluate the impact of lipid source on GE and ether extract (EE) digestibility, oxidative stress, and gut integrity in nursery pigs fed diets containing 10% soybean oil (SO), choice white grease (CWG), palm oil (PO), distillers' corn oil with approximately 5% FFA (DCO-1), or distillers' corn oil with approximately 10% FFA (DCO-2). Fifty-four barrows weaned at 28 d of age were fed a common starter diet for 7 d, group fed their respective experimental diets for an additional 7 d, and then moved to metabolism crates and individually fed their respective diets for another 10 d. Following this period, a 4-d total fecal and urine collection period was used to determine apparent total tract digestibility (ATTD) of GE and EE and to determine the DE and ME content of each lipid source (11.03 ± 0.51 kg final BW). Following the last day of fecal and urine collection, pigs were given an oral dose of lactulose and mannitol and fed their respective experimental diets with urine collected for the following 12 h. A subsequent urine collection occurred for 5 h to determine thiobarbituric acid reactive substances (TBARS) and isoprostane (IsoP) concentrations. Following this urine collection, serum was obtained and analyzed for TBARS and endotoxin concentrations. Soybean oil had the greatest ( < 0.05) DE (9,388 kcal/kg) content compared with DCO-1, DCO-2, CWG, and PO (8,001, 8,052, 8,531, and 8,293 kcal/kg lipid, respectively). Energy digestibility was greatest for SO compared with the other lipid sources ( < 0.05). The ATTD of EE averaged 85.0% and varied slightly (84.4 to 85.6%) among treatments. Differences in ME content among lipids were similar to those reported for DE, with ME values for DCO-1, DCO-2, CWG, PO, and SO being 7,921, 7,955, 8,535, 8,350, and 9,408 kcal/kg lipid, respectively. Metabolizable energy as a percentage of DE did not differ among lipid sources. Pigs fed lipid diets had greater ( < 0.05) serum TBARS compared with pigs fed the control diet, but no differences were observed in urinary TBARS excretion among the lipid treatments. Urinary IsoP excretion differed among treatments ( < 0.01) but was highly variable (34.0 to 104.6 pg). However, no differences were observed among treatments for the urinary lactulose:mannitol ratio and serum endotoxin. These results indicate that DE and ME content of SO are greater than that of other lipid sources evaluated, but feeding these lipids has no effect on gut integrity while producing variable effects on oxidative stress.
[Mh] Termos MeSH primário: Gorduras na Dieta/metabolismo
Metabolismo Energético
Metabolismo dos Lipídeos
Suínos/fisiologia
[Mh] Termos MeSH secundário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Animais
Óleo de Milho/metabolismo
Dieta/veterinária
Digestão
Fezes
Isoprostanos/análise
Masculino
Estresse Oxidativo
Óleo de Palmeira
Óleos Vegetais/metabolismo
Óleo de Soja/metabolismo
Substâncias Reativas com Ácido Tiobarbitúrico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Isoprostanes); 0 (Plant Oils); 0 (Thiobarbituric Acid Reactive Substances); 5QUO05548Z (Palm Oil); 8001-22-7 (Soybean Oil); 8001-30-7 (Corn Oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.0915


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[PMID]:28117688
[Au] Autor:Wall-Medrano A; de la Rosa LA; Vázquez-Flores AA; Mercado-Mercado G; González-Arellanes R; López-Díaz JA; González-Córdova AF; González-Aguilar GA; Vallejo-Cordoba B; Molina-Corral FJ
[Ad] Endereço:Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico. awall@uacj.mx.
[Ti] Título:Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats.
[So] Source:Nutrients;9(1), 2017 Jan 20.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Specialty oils differ in fatty acid, phytosterol and antioxidant content, impacting their benefits for cardiovascular health. The lipid (fatty acid, phytosterol) and antioxidant (total phenolics, radical scavenging capacity) profiles of grapeseed (GSO), corn (CO) and coconut (CNO) oils and their physiological (triacylglycerides, total and HDL-cholesterol and antioxidant capacity (FRAP) in serum and fatty acid and phytosterol hepatic deposition) and genomic (HL, LCAT, ApoA-1 and SR-BP1 mRNA hepatic levels) responses after their sub-chronic intake (10% diet for 28 days) was examined in healthy albino rats. Fatty acid, phytosterol and antioxidant profiles differed between oils ( ≤ 0.01). Serum and hepatic triacylglycerides and total cholesterol increased ( ≤ 0.01); serum HDL-Cholesterol decreased ( < 0.05); but serum FRAP did not differ ( > 0.05) in CNO-fed rats as compared to CO or GSO groups. Hepatic phytosterol deposition was higher (+2.2 mg/g; ≤ 0.001) in CO- than GSO-fed rats, but their fatty acid deposition was similar. All but ApoA-1 mRNA level increased in GSO-fed rats as compared to other groups ( ≤ 0.01). Hepatic fatty acid handling, but not antioxidant response, nor hepatic phytosterol deposition, could be related to a more efficient reverse-cholesterol transport in GSO-fed rats as compared to CO or CNO.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Gorduras Insaturadas na Dieta/uso terapêutico
Regulação da Expressão Gênica
Hiperlipidemias/prevenção & controle
Metabolismo dos Lipídeos
Fígado/metabolismo
Óleos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/efeitos adversos
Antioxidantes/análise
Antioxidantes/química
Biomarcadores/sangue
Biomarcadores/metabolismo
HDL-Colesterol/agonistas
HDL-Colesterol/antagonistas & inibidores
HDL-Colesterol/sangue
Óleo de Coco
Óleo de Milho/efeitos adversos
Óleo de Milho/química
Óleo de Milho/uso terapêutico
Gorduras Insaturadas na Dieta/efeitos adversos
Ácidos Graxos/efeitos adversos
Ácidos Graxos/análise
Ácidos Graxos/metabolismo
Ácidos Graxos/uso terapêutico
Hiperlipidemias/sangue
Hiperlipidemias/etiologia
Masculino
Capacidade de Absorbância de Radicais de Oxigênio
Fenóis/efeitos adversos
Fenóis/análise
Fenóis/uso terapêutico
Fitosteróis/efeitos adversos
Fitosteróis/análise
Fitosteróis/metabolismo
Fitosteróis/uso terapêutico
Óleos Vegetais/efeitos adversos
Óleos Vegetais/química
Óleos Vegetais/metabolismo
Distribuição Aleatória
Ratos Wistar
Sementes/química
Organismos Livres de Patógenos Específicos
Vitis/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 0 (Cholesterol, HDL); 0 (Dietary Fats, Unsaturated); 0 (Fatty Acids); 0 (Phenols); 0 (Phytosterols); 0 (Plant Oils); 8001-30-7 (Corn Oil); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28116392
[Au] Autor:Salvia-Trujillo L; Fumiaki B; Park Y; McClements DJ
[Ad] Endereço:Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. mcclements@foodsci.umass.edu.
[Ti] Título:The influence of lipid droplet size on the oral bioavailability of vitamin D encapsulated in emulsions: an in vitro and in vivo study.
[So] Source:Food Funct;8(2):767-777, 2017 Feb 22.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vitamin D deficiency is prevalent in some populations leading to adverse health effects, and therefore there is a need to supplement functional foods and beverages with this important micronutrient. In this study, we examined the influence of the initial lipid droplet size on the in vitro bioaccessibility and in vivo absorption of vitamin D encapsulated in oil-in-water emulsions. Changes in particle size, charge, and microstructure were measured as vitamin-loaded lipid droplets were passed through a simulated GIT (mouth, stomach, small intestine). The in vitro studies showed that smaller lipid droplets were digested more rapidly than larger ones, thereby leading to the more rapid formation of mixed micelles in the small intestine capable of solubilizing the lipophilic vitamins. This effect may account for the highest vitamin D bioaccessibility being observed for the emulsions containing the smallest droplets. In contrast, the in vivo rat feeding studies suggested that the absorption of vitamin D was the highest for the emulsions containing the largest droplets. The poor in vitro-in vivo correlation observed in our study may have occurred for a number of reasons: the simulated GIT did not accurately model the complexity of a real GIT; the in vivo approach used did not monitor changes in vitamin levels in the blood over time. Overall, this study suggests that particle size does influence the gastrointestinal fate of encapsulated oil-soluble vitamins, but that further work is needed to establish strong correlations between in vitro and in vivo methods.
[Mh] Termos MeSH primário: Óleo de Milho/química
Ergocalciferóis/farmacocinética
[Mh] Termos MeSH secundário: Administração Oral
Animais
Disponibilidade Biológica
Suplementos Nutricionais/análise
Composição de Medicamentos
Sistemas de Liberação de Medicamentos
Emulsões/química
Emulsões/farmacocinética
Ergocalciferóis/química
Trato Gastrointestinal/metabolismo
Tamanho da Partícula
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Ergocalciferols); 8001-30-7 (Corn Oil)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo01565d



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