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[PMID]:28813468
[Au] Autor:He T; Zhang H; Wang J; Wu S; Yue H; Qi G
[Ad] Endereço:Key Laboratory of Feed Biotechnology of Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
[Ti] Título:Proteomic comparison by iTRAQ combined with mass spectrometry of egg white proteins in laying hens (Gallus gallus) fed with soybean meal and cottonseed meal.
[So] Source:PLoS One;12(8):e0182886, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cottonseed meal (CSM) is commonly used in hens' diets to replace soybean meal (SBM). However, the molecular consequences of this substitution remains unclear. To investigate the impact of this substitution at the molecular level, iTRAQ combined with biochemical analysis was performed in Hy-Line W-36 hens supplemented with a mixed diet of CSM and SBM. Egg weight, albumen height, and Haugh unit were significantly reduced in the CSM100 group (100% crude protein of SBM replaced by CSM) compared with the SBM group (P<0.05). A total of 15 proteins, accounting for 75% of egg white proteins with various biological functions of egg whites, were found to be reduced. This finding may relate to the decrease of albumen quality in the CSM100 group. Oviduct magnum morphology and hormone analysis indicated that a reduced level of plasma progesterone caused reduced growth of the tubular gland and epithelial cells in the magnum, further decreasing egg white protein synthesis in the magnum. These findings help demonstrate the molecular mechanisms of a CSM diet that cause adverse effects on albumen quality, while also showing that SBM should not be totally replaced with CSM in a hen diet.
[Mh] Termos MeSH primário: Galinhas/fisiologia
Óleo de Sementes de Algodão
Dieta/veterinária
Proteínas do Ovo/metabolismo
Espectrometria de Massas
Proteômica
Feijão de Soja
[Mh] Termos MeSH secundário: Animais
Eletroforese em Gel Bidimensional
Feminino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (Egg Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182886


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[PMID]:28370760
[Au] Autor:Bahraini Z; Salari S; Sari M; Fayazi J; Behgar M
[Ad] Endereço:Department of Animal Science, Animal Science and Food Technology Faculty, Ramin Agriculture and Natural Resources University of Khouzestan, Ahwaz, Iran.
[Ti] Título:Effect of radiation on chemical composition and protein quality of cottonseed meal.
[So] Source:Anim Sci J;88(9):1425-1435, 2017 Sep.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:This study was conducted to compare the effects of electron beam (EB) and gamma ray (GR) irradiation treatments at doses of 10, 20 and 30 kGy on chemical composition, protein quality and protein digestibility of cottonseed meal (CSM). GR irradiation in all doses significantly decreased the crude fiber of samples compared to raw CSM. Free and total gossypol content of CSM was decreased significantly by utilizing both types of irradiation in a dose-dependent manner. Also, EB irradiation caused decrease in free and total gossypol content more than that of GR irradiation. GR irradiation at doses of 20 and 30 kGy, and EB irradiation at doses of 10, 20 and 30 kGy can significantly decrease protein solubility of CSM compared to that of a raw sample. GR irradiation at a dose of 30 kGy significantly increased apparent digestibility of protein compared to raw and EB irradiation of CSM at a dose of 10 kGy in Leghorn cockerels. Maximum increase in protein digestibility of CSM was observed in GR irradiation at a dose of 30 kGy. In conclusion, the present study showed that EB and GR irradiation reduced gossypol and crude fiber and increased protein digestibility of CSM but had no effect on protein quality of CSM.
[Mh] Termos MeSH primário: Ração Animal/análise
Ração Animal/efeitos da radiação
Óleo de Sementes de Algodão/química
Óleo de Sementes de Algodão/efeitos da radiação
Fibras na Dieta/efeitos da radiação
Proteínas na Dieta/efeitos da radiação
Qualidade dos Alimentos
Raios gama
[Mh] Termos MeSH secundário: Animais
Galinhas/sangue
Galinhas/fisiologia
Óleo de Sementes de Algodão/análise
Digestão
Relação Dose-Resposta à Radiação
Elétrons
Gossipol/análise
Dose de Radiação
Solubilidade
Ácido Úrico/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (Dietary Fiber); 0 (Dietary Proteins); 268B43MJ25 (Uric Acid); KAV15B369O (Gossypol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12784


  3 / 795 MEDLINE  
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[PMID]:27988886
[Au] Autor:Shockey J; Dowd M; Mack B; Gilbert M; Scheffler B; Ballard L; Frelichowski J; Mason C
[Ad] Endereço:Commodity Utilization Research Unit, United States Department of Agriculture-Agricultural Research Service, Southern Regional Research Center, New Orleans, LA, USA. Jay.Shockey@ars.usda.gov.
[Ti] Título:Naturally occurring high oleic acid cottonseed oil: identification and functional analysis of a mutant allele of Gossypium barbadense fatty acid desaturase-2.
[So] Source:Planta;245(3):611-622, 2017 Mar.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: Some naturally occurring cotton accessions contain commercially attractive seed oil fatty acid profiles. The likely causal factor for a high-oleate trait in pima cotton ( Gossypium barbadense ) accession GB-713 is described here. Vegetable oils are broadly used in the manufacture of many human and animal nutritional products, and in various industrial applications. Along with other well-known edible plant oils from soybean, corn, and canola, cottonseed oil is a valuable commodity. Cottonseed oil is a co-product derived from the processing of cottonseed fiber. In the past, it was used extensively in a variety of food applications. However, cottonseed oil has lost market share in recent years due to less than optimal ratios of the constituent fatty acids found in either traditional or partially hydrogenated oil. Increased awareness of the negative health consequences of dietary trans-fats, along with the public wariness associated with genetically modified organisms has created high demand for naturally occurring oil with high monounsaturate/polyunsaturate ratios. Here, we report the discovery of multiple exotic accessions of pima cotton that contain elevated seed oil oleate content. The genome of one such accession was sequenced, and a mutant candidate fatty acid desaturase-2 (FAD2-1D) gene was identified. The mutant protein produced significantly less linoleic acid in infiltrated Arabidopsis leaf assays, compared to a repaired version of the same enzyme. Identification of this gene provides a valuable resource. Development of markers associated with this mutant locus will be very useful in efforts to breed the high-oleate trait into agronomic fiber accessions of upland cotton.
[Mh] Termos MeSH primário: Alelos
Óleo de Sementes de Algodão/química
Ácidos Graxos Dessaturases/genética
Gossypium/enzimologia
Mutação/genética
Ácido Oleico/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Cromatografia Gasosa
Ácidos Graxos Dessaturases/metabolismo
Regulação da Expressão Gênica de Plantas
Genes de Plantas
Gossypium/genética
Ácido Linoleico/análise
Filogenia
Estabilidade de RNA/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (RNA, Messenger); 2UMI9U37CP (Oleic Acid); 9KJL21T0QJ (Linoleic Acid); EC 1.14.19.- (Fatty Acid Desaturases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-016-2633-0


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[PMID]:27796643
[Au] Autor:Shang X; Cheng C; Ding J; Guo W
[Ad] Endereço:State Key Laboratory of Crop Genetics and Germplasm Enhancement, Hybrid Cotton R&D Engineering Research Center, Ministry of Education, Nanjing Agricultural University, Nanjing, 210095, China.
[Ti] Título:Identification of candidate genes from the SAD gene family in cotton for determination of cottonseed oil composition.
[So] Source:Mol Genet Genomics;292(1):173-186, 2017 Feb.
[Is] ISSN:1617-4623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cotton is an economically important crop grown for natural fiber and seed oil production. Cottonseed oil ranks third after soybean oil and colza oil in terms of edible oilseed tonnage worldwide. The fatty acid composition of cottonseed oil determines its industrial application and nutritional values. However, little progress has been made in understanding cottonseed oil biogenesis. Stearoyl-acyl carrier protein desaturase (SAD), the only known enzyme to convert saturated fatty acids into unsaturated fatty acids in plants, plays key roles in determining the fatty acid composition of cottonseed oil. In this study, we identified 9, 9, 18 and 19 SAD genes in the genomes of four sequenced cotton species: diploid Gossypium raimondii (D ), G. arboreum (A ), tetraploid G. hirsutum acc. TM-1 (AD ) and G. barbadense cv. Xinhai21 (AD ), respectively. Bioinformatic and phylogenetic analyses revealed that cotton SADs can be classified into two classes. Expression patterns showed developmental and spatial regulation of SADs in cotton. GhSAD2 and GhSAD4 were preferentially expressed in developing ovules 20-35 days post-anthesis, and significantly different expression patterns were found between high-oil and low-oil cotton cultivars, implying these two genes could be involved in cottonseed oil biogenesis. Association analysis further confirmed that GhSAD4-At expression was closely related to the oleic acid (O) content, linoleic acid (L) content and O/L value in cottonseed, implying GhSAD4 plays an important role in cottonseed oil composition. This study brings new perspectives for integrated genome-wide identification of SADs in cotton and provides references for the genetic improvement of cottonseed oil.
[Mh] Termos MeSH primário: Óleo de Sementes de Algodão/química
Ácidos Graxos/análise
Gossypium/enzimologia
Gossypium/genética
Oxigenases de Função Mista/genética
[Mh] Termos MeSH secundário: Família Multigênica
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (Fatty Acids); EC 1.- (Mixed Function Oxygenases); EC 1.14.19.2 (acyl-(acyl-carrier-protein)desaturase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1007/s00438-016-1265-1


  5 / 795 MEDLINE  
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[PMID]:27665012
[Au] Autor:Liu J; Song WJ; Zhang NY; Tan J; Krumm CS; Sun LH; Qi DS
[Ad] Endereço:Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
[Ti] Título:Biodetoxification of aflatoxin B1 in cottonseed meal by fermentation of Cellulosimicrobium funkei in duckling diet.
[So] Source:Poult Sci;96(4):923-930, 2017 Apr 01.
[Is] ISSN:1525-3171
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two experiments were conducted to optimize the fermentation of cottonseed meal by Cellulosimicrobium funkei (C. funkei) for the ability of the bacteria to degrade aflatoxin B1 (AFB1) and then to evaluate the bacterial detoxification in ducklings. In experiment 1, the fermentation of cottonseed meal by C. funkei was improved by changing the inoculation amounts by 10% (108 cfu/mL), using a 1:0.5 material to water ratio at 35°C temperature for a 144 h reaction duration, which resulted in an 83.4% biodegradation of AFB1. In experiment 2, 112 one-day-old male Cherry Valley ducklings were randomly allocated to 4 experimental groups with 4 replicates of 7 birds each. For a period of 2 wk the controls received a base duckling diet (BD), a second group received a base diet contaminated with 10% AFB1 cottonseed meal (96.8 µg AFB1/kg), a third group was fed a base diet added with 5% unfermented and 5% fermented AFB1-contaminated cottonseed meal (57.0 µg AFB1/kg), and the fourth group was fed a base diet added with 10% AFB1-contaminated fermented cottonseed meal (16.0 µg AFB1/kg). The growth performance, relative organ weights, and serum biochemistry were analyzed. The results showed that the feed conversion ratio in the second group was lower than that of the controls at wk one and 2 (P < 0.05). Also, after 2 wk, group 2 ducklings had increased relative weights of the liver, kidneys, and spleen, increased activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), increased concentration of blood urea nitrogen (BUN) and creatinine (Crt), and decreased relative weight of Fabricius bursa (P < 0.05). In addition, the concentrations of total protein (TP) and albumin (ALB) in serum were also significantly higher at weeks one and 2 (P < 0.05). These alterations were attenuated or prevented when 5 or 10% fermented cottonseed meal substituted equal amounts of unfermented cottonseed meal in the diet. In conclusion, fermentation of AFB1-contaminated feed materials by C. funkei offers a new strategy to reduce the negative effects of aflatoxicosis in ducklings.
[Mh] Termos MeSH primário: Actinobacteria/metabolismo
Aflatoxina B1/metabolismo
Ração Animal/análise
Óleo de Sementes de Algodão/análise
Patos/fisiologia
Valor Nutritivo
[Mh] Termos MeSH secundário: Aflatoxina B1/análise
Animais
Dieta/veterinária
Fermentação
Masculino
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE
[do] DOI:10.3382/ps/pew352


  6 / 795 MEDLINE  
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[PMID]:27646908
[Au] Autor:Grewal J; Khare SK
[Ad] Endereço:Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.
[Ti] Título:2-Pyrrolidone synthesis from γ-aminobutyric acid produced by Lactobacillus brevis under solid-state fermentation utilizing toxic deoiled cottonseed cake.
[So] Source:Bioprocess Biosyst Eng;40(1):145-152, 2017 Jan.
[Is] ISSN:1615-7605
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:There is an increasing demand of γ-aminobutyric acid (GABA) as drug and food additive, as well as feedstock to produce 2-pyrrolidone, a precursor for the synthesis of nylon 4. 2-Pyrrolidone is a petrochemical and depleting reserve which raises concern for its bio-based production. The study herein describes bio-based economical GABA production from Lactobacillus brevis by solid-state fermentation (SSF) using toxic deoiled cottonseed cake (CSC) as substrate. In general, the use of cottonseed cake remains restricted due to the presence of toxic gossypols. Thus, simultaneous detoxification observed during fermentation also widens the scope of utilization of this residual seedcake for feed use vis-a-vis production of other value added chemicals. The SSF conditions were optimized for maximum GABA production, viz., 19.7 mg/g, CSC of GABA was obtained at 6th day of fermentation with 70 % degradation of gossypols simultaneously. The potential of this bio-based GABA as a platform chemical is demonstrated in the synthesis of 2-pyrrolidone. Thus, a simple and cost-effective strategy for utilizing toxic biomass has been developed as an alternate to chemical synthetic route.
[Mh] Termos MeSH primário: Óleo de Sementes de Algodão/química
Óleo de Sementes de Algodão/metabolismo
Gossypium/química
Lactobacillus brevis/crescimento & desenvolvimento
Pirrolidinonas/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Mh] Termos MeSH secundário: Ácido gama-Aminobutírico/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (Pyrrolidinones); 56-12-2 (gamma-Aminobutyric Acid); KKL5D39EOL (2-pyrrolidone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1007/s00449-016-1683-9


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[PMID]:27444442
[Au] Autor:Zhang F; Adeola O
[Ad] Endereço:Department of Animal Sciences, Purdue University, West Lafayette, IN 47907.
[Ti] Título:Energy values of canola meal, cottonseed meal, bakery meal, and peanut flour meal for broiler chickens determined using the regression method.
[So] Source:Poult Sci;96(2):397-404, 2017 Feb 01.
[Is] ISSN:1525-3171
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The energy values of canola meal (CM), cottonseed meal (CSM), bakery meal (BM), and peanut flour meal (PFM) for broiler chickens were determined in 2 experiments with Ross 708 broiler chickens from d 21 to 28 posthatch. The birds were fed a standard broiler starter diet from d 0 to 21 posthatch. In each experiment, 320 birds were grouped by weight into 8 blocks of 5 cages with 8 birds per cage and assigned to 5 diets. Each experiment used a corn-soybean meal reference diet and 4 test diets in which test ingredients partly replaced the energy sources in the reference diet. The test diets in Exp. 1 consisted of 125 g CM, 250 g CM, 100 g CSM, or 200 g CSM/kg. In Exp. 2, the test diets consisted of 200 g BM, 400 g BM, 100 g PFM, or 200 g PFM/kg. The ileal digestible energy (IDE), metabolizable energy (ME), and nitrogen-corrected metabolizable energy (ME ) of all the test ingredients were determined by the regression method. The DM of CM, CSM, BM and PFM were 883, 878, 878, and 964 g/kg, respectively and the respective gross energies (GE) were 4,143, 4,237, 4,060, and 5,783 kcal/kg DM. In Exp. 1, the IDE were 2,132 and 2,197 kcal/kg DM for CM and CSM, respectively. The ME were 2,286 and 2,568 kcal/kg DM for CM and CSM, respectively. The ME were 1,931 kcal/kg DM for CM and 2,078 kcal/ kg DM for CSM. In Exp. 2, IDE values were 3,412 kcal/kg DM for BM and 4,801 kcal/kg DM for PFM; ME values were 3,176 and 4,601 kcal/kg DM for BM and PFM, respectively, and the ME values were 3,093 kcal/kg DM for BM and 4,112 kcal/kg DM for PFM. In conclusion, the current study showed that chickens can utilize a considerable amount of energy from these 4 ingredients, and also provided the energy values of CM, CSM, BM and PFM for broiler chickens.
[Mh] Termos MeSH primário: Ração Animal/análise
Galinhas/metabolismo
Ingestão de Energia
Metabolismo Energético
[Mh] Termos MeSH secundário: Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Arachis/química
Brassica/química
Óleo de Sementes de Algodão/química
Dieta/veterinária
Digestão
Relação Dose-Resposta a Droga
Farinha
Masculino
Distribuição Aleatória
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.3382/ps/pew239


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[PMID]:27381745
[Au] Autor:Liu Q; Wu M; Zhang B; Shrestha P; Petrie J; Green AG; Singh SP
[Ad] Endereço:CSIRO Agriculture & Food, Canberra, ACT, Australia.
[Ti] Título:Genetic enhancement of palmitic acid accumulation in cotton seed oil through RNAi down-regulation of ghKAS2 encoding ß-ketoacyl-ACP synthase II (KASII).
[So] Source:Plant Biotechnol J;15(1):132-143, 2017 Jan.
[Is] ISSN:1467-7652
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Palmitic acid (C16:0) already makes up approximately 25% of the total fatty acids in the conventional cotton seed oil. However, further enhancements in palmitic acid content at the expense of the predominant unsaturated fatty acids would provide increased oxidative stability of cotton seed oil and also impart the high melting point required for making margarine, shortening and confectionary products free of trans fatty acids. Seed-specific RNAi-mediated down-regulation of ß-ketoacyl-ACP synthase II (KASII) catalysing the elongation of palmitoyl-ACP to stearoyl-ACP has succeeded in dramatically increasing the C16 fatty acid content of cotton seed oil to well beyond its natural limits, reaching up to 65% of total fatty acids. The elevated C16 levels were comprised of predominantly palmitic acid (C16:0, 51%) and to a lesser extent palmitoleic acid (C16:1, 11%) and hexadecadienoic acid (C16:2, 3%), and were stably inherited. Despite of the dramatic alteration of fatty acid composition and a slight yet significant reduction in oil content in these high-palmitic (HP) lines, seed germination remained unaffected. Regiochemical analysis of triacylglycerols (TAG) showed that the increased levels of palmitic acid mainly occurred at the outer positions, while C16:1 and C16:2 were predominantly found in the sn-2 position in both TAG and phosphatidylcholine. Crossing the HP line with previously created high-oleic (HO) and high-stearic (HS) genotypes demonstrated that HP and HO traits could be achieved simultaneously; however, elevation of stearic acid was hindered in the presence of high level of palmitic acid.
[Mh] Termos MeSH primário: 3-Oxoacil-(Proteína de Transporte de Acila) Sintase/genética
Óleo de Sementes de Algodão/análise
Regulação para Baixo
Melhoramento Genético
Gossypium/enzimologia
Gossypium/genética
Ácido Palmítico/análise
Interferência de RNA
[Mh] Termos MeSH secundário: Agrobacterium tumefaciens/genética
Sequência de Bases
Óleo de Sementes de Algodão/química
Ácidos Graxos/análise
Ácidos Graxos/química
Ácidos Graxos Monoinsaturados/química
Inativação Gênica
Genes de Plantas
Vetores Genéticos
Genótipo
Germinação
Lipídeos/análise
Lipídeos/química
Estresse Oxidativo
Ácido Palmítico/química
Fosfatidilcolinas/análise
Filogenia
Óleos Vegetais/análise
Proteínas de Plantas/genética
Plantas Geneticamente Modificadas/metabolismo
Sementes/genética
Alinhamento de Sequência
Ácidos Esteáricos/análise
Transformação Genética
Triglicerídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Lipids); 0 (Phosphatidylcholines); 0 (Plant Oils); 0 (Plant Proteins); 0 (Stearic Acids); 0 (Triglycerides); 209B6YPZ4I (palmitoleic acid); 2V16EO95H1 (Palmitic Acid); 4ELV7Z65AP (stearic acid); EC 2.3.1.41 (3-Oxoacyl-(Acyl-Carrier-Protein) Synthase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160707
[St] Status:MEDLINE
[do] DOI:10.1111/pbi.12598


  9 / 795 MEDLINE  
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[PMID]:27128796
[Au] Autor:Myat TS; Tetsuka M
[Ad] Endereço:Division of Animal Production, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, Japan.
[Ti] Título:Gossypol inhibits LH-induced steroidogenesis in bovine theca cells.
[So] Source:Anim Sci J;88(1):63-71, 2017 Jan.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Gossypol, a polyphenolic aldehyde found in cottonseed, has been shown to perturb steroidogenesis in granulosa and luteal cells of rats, pigs and cattle. However, little is known about the direct effect of gossypol on theca cell functions in any species. The present study was conducted to investigate the effect of gossypol on the steroidogenesis and the expression of genes involved in it in cultured bovine theca cells. Theca cells were isolated from healthy preovulatory follicles and were cultured in the presence of luteinizing hormone (LH) for up to 7 days. During the culture period, main steroid products of the theca cells shifted from androstenedione (A4) at day 1 to progesterone (P4) from day 2 onward. At days 1 and 7, theca cells were treated with gossypol (0-25 µg/mL) for 24 h. Gossypol inhibited LH-stimulated theca cell A4 and P4 production in a dose-dependent manner at both occasions. The viability of theca cells was not affected by gossypol at any doses used. Gossypol down-regulated expressions of steroidogenic enzymes CYP11A1, HSD3B1 and CYP17A1, but not that of LHR. These results indicate that gossypol inhibits thecal steroidogenesis through down-regulating gene expressions of steroidogenic enzymes but without affecting cell viability in cattle.
[Mh] Termos MeSH primário: Androstenodiona/biossíntese
Gossipol/farmacologia
Hormônio Luteinizante/farmacologia
Progesterona/biossíntese
Células Tecais/metabolismo
[Mh] Termos MeSH secundário: Animais
Bovinos
Células Cultivadas
Enzima de Clivagem da Cadeia Lateral do Colesterol/genética
Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo
Óleo de Sementes de Algodão
Relação Dose-Resposta a Droga
Regulação para Baixo/efeitos dos fármacos
Feminino
Expressão Gênica/efeitos dos fármacos
Complexos Multienzimáticos/genética
Complexos Multienzimáticos/metabolismo
Progesterona Redutase/genética
Progesterona Redutase/metabolismo
Esteroide 17-alfa-Hidroxilase/genética
Esteroide 17-alfa-Hidroxilase/metabolismo
Esteroide Isomerases/genética
Esteroide Isomerases/metabolismo
Células Tecais/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase); 0 (Cottonseed Oil); 0 (Multienzyme Complexes); 409J2J96VR (Androstenedione); 4G7DS2Q64Y (Progesterone); 9002-67-9 (Luteinizing Hormone); EC 1.1.1.145 (Progesterone Reductase); EC 1.14.14.19 (CYP17A1 protein, human); EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase); EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme); EC 5.3.3.- (Steroid Isomerases); KAV15B369O (Gossypol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160430
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12596


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[PMID]:27472154
[Au] Autor:Pereira ES; Mizubuti IY; Oliveira RL; Pinto AP; Ribeiro EL; Gadelha CR; Campos AC; Pereira MF; Carneiro MS; Arruda PC; Silva LP
[Ad] Endereço:the Lab. Animal Nutrition, Dept. of Animal Science, Federal Univ. of Ceara, Fortaleza, 60021970, Brazil. elzania@hotmail.com.
[Ti] Título:Supplementation with Cashew Nut and Cottonseed Meal to Modify Fatty Acid Content in Lamb Meat.
[So] Source:J Food Sci;81(9):C2143-8, 2016 Sep.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study evaluates the effect of cashew nut meal (CNM), whole cottonseed (WCS), and calcium salts of long-chain fatty acids (Ca-LCFA) on the fatty acid profiles of meat from hair lambs. Thirty-five 60-d-old, male, noncastrated Santa Ines lambs with an initial average body weight of 13.00 ± 1.80 kg were used in a randomized complete-block design with 7 blocks and 5 treatments. The experimental treatments consisted of a control diet (CON) without supplemental lipids and 4 test diets with different lipid supplements that were selected according to the degree of protection from ruminal hydrogenation and their polyunsaturated fatty acid richness. The tests diets included the following modifications: supplementation with WCS, supplementation with CNM, supplementation with both cottonseed and CNM (CSCNM), and supplementation with Ca-LCFA. The C18:1n9c content was highest in the meat of the animals fed the CNM diet (42.00%). The meat from lambs fed the WCS and Ca-LCFA diets had higher C18:0 contents (25.23 and 22.80%, respectively). The C16:1 content was higher in the meat from the animals fed the CNM and CON diets (1.54 and 1.49%, respectively). C18:2c9t11 concentration was higher in the meat from the animals fed the Ca-LCFA and CNM diets. The estimated enzyme activity of Δ9-desaturase C18 was highest in the muscles of the lambs fed the CON, CNM, and CSCNM diets. The use of cashew nuts in the diet resulted in an increase in the C18:2c9t11 content of the lamb meat, which improved the nutritional characteristics of the fat.
[Mh] Termos MeSH primário: Anacardium/química
Óleo de Sementes de Algodão/química
Ácidos Graxos Insaturados/análise
Nozes/química
Carne Vermelha/análise
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Peso Corporal
Dieta/veterinária
Análise de Alimentos
Masculino
Músculo Esquelético/química
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cottonseed Oil); 0 (Fatty Acids, Unsaturated)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13395



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