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[PMID]:29367478
[Au] Autor:Sun M; Xu X; Zhang Q; Rui X; Wu J; Dong M
[Ad] Endereço:College of Food Science and Technology, Nanjing Agricultural University.
[Ti] Título:Ultrasonic-assisted Aqueous Extraction and Physicochemical Characterization of Oil from Clanis bilineata.
[So] Source:J Oleo Sci;67(2):151-165, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Ultrasound-assisted aqueous extraction (UAAE) was used to extract oil from Clanis bilineata (CB), a traditional edible insect that can be reared on a large scale in China, and the physicochemical property and antioxidant capacity of the UAAE-derived oil (UAAEO) were investigated for the first time. UAAE conditions of CB oil was optimized using response surface methodology (RSM) and the highest oil yield (19.47%) was obtained under optimal conditions for ultrasonic power, extraction temperature, extraction time, and ultrasonic interval time at 400 W, 40°C, 50 min, and 2 s, respectively. Compared with Soxhlet extraction-derived oil (SEO), UAAEO had lower acid (AV), peroxide (PV) and p-anisidine values (PAV) as well as higher polyunsaturated fatty acids contents and thermal stability. Furthermore, UAAEO showed stronger antioxidant activities than those of SEO, according to DPPH radical scavenging and ß-carotene bleaching tests. Therefore, UAAE is a promising process for the large-scale production of CB oil and CB has a developing potential as functional oil resource.
[Mh] Termos MeSH primário: Fenômenos Químicos
Larva/química
Lepidópteros/química
Extração Líquido-Líquido/métodos
Óleos/química
Óleos/isolamento & purificação
Ultrassom
Água
[Mh] Termos MeSH secundário: Animais
Antioxidantes
Ácidos Graxos Insaturados/análise
Óleos/farmacologia
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fatty Acids, Unsaturated); 0 (Oils); 059QF0KO0R (Water)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17108


  2 / 17774 MEDLINE  
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[PMID]:29353041
[Au] Autor:Hayashi Y; Shimamura A; Ishikawa T; Fujiwara Y; Ichi I
[Ad] Endereço:Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo, Japan.
[Ti] Título:FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion.
[So] Source:Biochem Biophys Res Commun;496(2):549-555, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fatty acid desaturase 2 (FADS2) is responsible for the first desaturation reaction in the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4n-6) and eicosapentaenoic acid (20:5n-3), and is involved in Mead acid (20:3n-9) production during essential fatty acid deficiency (EFAD). In this study, an obvious hepatic lipid accumulation was observed in EFAD mice treated with a FADS2 inhibitor. FADS2 inhibition in the EFAD state reduced secretion of very low-density lipoprotein (VLDL) and markedly diminished Mead acid in phosphatidylcholine (PC) in the liver and plasma. As the results, the amount of C20 HUFAs in hepatic and plasma PC dramatically reduced in the EFAD mice treated with a FADS2 inhibitor, whereas the decrease of C20 HUFA levels of PC in EFAD mice was not observed because of the increased Mead acid in PC. These results supposed that Mead acid in PC is important as a component of VLDL. It is possible that Mead acid plays the role of a substitute of HUFAs in VLDL secretion during EFAD.
[Mh] Termos MeSH primário: Ácidos Graxos Dessaturases/metabolismo
Ácidos Graxos Insaturados/metabolismo
Lipoproteínas VLDL/metabolismo
Fígado/metabolismo
[Mh] Termos MeSH secundário: Ácido 8,11,14-Eicosatrienoico/análogos & derivados
Ácido 8,11,14-Eicosatrienoico/metabolismo
Animais
Ácidos Graxos Dessaturases/antagonistas & inibidores
Fígado Gorduroso/metabolismo
Metabolismo dos Lipídeos
Masculino
Camundongos Endogâmicos C57BL
Oxirredução
Fosfatidilcolinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); 0 (Lipoproteins, VLDL); 0 (Phosphatidylcholines); 7324-41-6 (8,11,14-Eicosatrienoic Acid); EC 1.14.19.- (Fatty Acid Desaturases); EC 1.14.19.3 (FADS2 protein, mouse); JQS194YH3X (mead acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180122
[St] Status:MEDLINE


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[PMID]:28465173
[Au] Autor:Xue J; Balamurugan S; Li DW; Liu YH; Zeng H; Wang L; Yang WD; Liu JS; Li HY
[Ad] Endereço:Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
[Ti] Título:Glucose-6-phosphate dehydrogenase as a target for highly efficient fatty acid biosynthesis in microalgae by enhancing NADPH supply.
[So] Source:Metab Eng;41:212-221, 2017 05.
[Is] ISSN:1096-7184
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Oleaginous microalgae have great prospects in the fields of feed, nutrition, biofuel, etc. However, biomass and lipid productivity in microalgae remain a major economic and technological bottleneck. Here we present a novel regulatory target, glucose-6-phosphate dehydrogenase (G6PD) from the pentose phosphate pathway (PPP), in boosting microalgal lipid accumulation. G6PD, involved in the formation of NADPH demanded in fatty acid biosynthesis as reducing power, was characterized in oleaginous microalga Phaeodactylum tricornutum. In G6PD overexpressing microalgae, transcript abundance of G6PD increased by 4.4-fold, and G6PD enzyme activity increased by more than 3.1-fold with enhanced NADPH production. Consequently, the lipid content increased by 2.7-fold and reached up to 55.7% of dry weight, while cell growth was not apparently affected. The fatty acid composition exhibited significant changes, including a remarkable increase in monounsaturated fatty acids C16:1 and C18:1 concomitant with a decrease in polyunsaturated fatty acids C20:5 and C22:6. G6PD was localized to the chloroplast and its overexpression stimulated an increase in the number and size of oil bodies. Proteomic and metabolomic analyzes revealed that G6PD play a key role in regulating pentose phosphate pathway and subsequently upregulating NADPH consuming pathways such as fatty acid synthesis, thus eventually leading to lipid accumulation. Our findings show the critical role of G6PD in microalgal lipid accumulation by enhancing NADPH supply and demonstrate that G6PD is a promising target for metabolic engineering.
[Mh] Termos MeSH primário: Proteínas de Cloroplastos
Diatomáceas
Ácidos Graxos Insaturados
Glucosefosfato Desidrogenase
Microalgas
NADP
[Mh] Termos MeSH secundário: Proteínas de Cloroplastos/genética
Proteínas de Cloroplastos/metabolismo
Diatomáceas/enzimologia
Diatomáceas/metabolismo
Ácidos Graxos Insaturados/biossíntese
Ácidos Graxos Insaturados/genética
Glucose-6-Fosfato/genética
Glucose-6-Fosfato/metabolismo
Glucosefosfato Desidrogenase/genética
Glucosefosfato Desidrogenase/metabolismo
Microalgas/enzimologia
Microalgas/genética
NADP/genética
NADP/metabolismo
Via de Pentose Fosfato/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chloroplast Proteins); 0 (Fatty Acids, Unsaturated); 53-59-8 (NADP); 56-73-5 (Glucose-6-Phosphate); EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  4 / 17774 MEDLINE  
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[PMID]:28521524
[Au] Autor:Roggatz CC; González-Wangüemert M; Pereira H; Vizetto-Duarte C; Rodrigues MJ; Barreira L; da Silva MM; Varela J; Custódio L
[Ad] Endereço:a Faculty of Sciences and Technology, Center of Marine Sciences (CCMAR) , University of Algarve , Faro , Portugal.
[Ti] Título:A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain).
[So] Source:Nat Prod Res;32(1):116-120, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work reports for the first time the nutritional profile, including proximate chemical composition, amino acids, fatty acids and minerals of Parastichopus regalis from the Mediterranean Sea (SE Spain). The studied species had a high moisture content, moderate protein and low lipid levels. The most abundant amino acids were glutamic acid, arginine and tyrosine. Polyunsaturated fatty acids, especially arachidonic acid, dominated the fatty acid profile. Iron, sodium, calcium and zinc were the most abundant mine rals. In general, P. regalis has a balanced nutritional quality suitable for human consumption.
[Mh] Termos MeSH primário: Aminoácidos/análise
Ácidos Graxos/análise
Minerais/análise
Valor Nutritivo
Pepinos-do-Mar/química
[Mh] Termos MeSH secundário: Animais
Ácidos Graxos Insaturados/análise
Mar Mediterrâneo
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Fatty Acids); 0 (Fatty Acids, Unsaturated); 0 (Minerals)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1331224


  5 / 17774 MEDLINE  
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[PMID]:29317615
[Au] Autor:An JU; Song YS; Kim KR; Ko YJ; Yoon DY; Oh DK
[Ad] Endereço:Department of Integrative Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea.
[Ti] Título:Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes.
[So] Source:Nat Commun;9(1):128, 2018 01 09.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hepoxilins (HXs) and trioxilins (TrXs) are involved in physiological processes such as inflammation, insulin secretion and pain perception in human. They are metabolites of polyunsaturated fatty acids (PUFAs), including arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid, formed by 12-lipoxygenase (LOX) and epoxide hydrolase (EH) expressed by mammalian cells. Here, we identify ten types of HXs and TrXs, produced by the prokaryote Myxococcus xanthus, of which six types are new, namely, HXB , HXD , HXE , TrXB , TrXD and TrXE . We succeed in the biotransformation of PUFAs into eight types of HXs (>35% conversion) and TrXs (>10% conversion) by expressing M. xanthus 12-LOX or 11-LOX with or without EH in Escherichia coli. We determine 11-hydroxy-eicosatetraenoic acid, HXB , HXB , HXD , TrXB and TrXD as potential peroxisome proliferator-activated receptor-γ partial agonists. These findings may facilitate physiological studies and drug development based on lipid mediators.
[Mh] Termos MeSH primário: Ácido 8,11,14-Eicosatrienoico/análogos & derivados
Ácidos Graxos Insaturados/metabolismo
Myxococcus xanthus/enzimologia
[Mh] Termos MeSH secundário: Ácido 8,11,14-Eicosatrienoico/química
Ácido 8,11,14-Eicosatrienoico/metabolismo
Araquidonato 12-Lipoxigenase/genética
Araquidonato 12-Lipoxigenase/metabolismo
Araquidonato Lipoxigenases/genética
Araquidonato Lipoxigenases/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Biotransformação
Epóxido Hidrolases/genética
Epóxido Hidrolases/metabolismo
Ácidos Graxos Insaturados/química
Redes e Vias Metabólicas/genética
Estrutura Molecular
Myxococcus xanthus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Fatty Acids, Unsaturated); 68860-46-8 (8,11,12-trihydroxy-5,9,14-eicosatrienoic acid); 7324-41-6 (8,11,14-Eicosatrienoic Acid); 85589-24-8 (8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid); EC 1.13.11.- (11-lipoxygenase); EC 1.13.11.- (Arachidonate Lipoxygenases); EC 1.13.11.31 (Arachidonate 12-Lipoxygenase); EC 3.3.2.- (Epoxide Hydrolases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02543-8


  6 / 17774 MEDLINE  
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[PMID]:29199310
[Au] Autor:Thorat RG; Harned AM
[Ad] Endereço:Texas Tech University, Department of Chemistry & Biochemistry, 1204 Boston Ave., Lubbock, TX 79409-1061, USA. andrew.harned@ttu.edu.
[Ti] Título:Rapid, enantioselective synthesis of the C1-C13 fragment of biselyngbyolide B.
[So] Source:Chem Commun (Camb);54(3):241-243, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A rapid synthesis of the C1-C13 fragment of biselynbyolide A and B is reported. The judicious use of catalytic transformations for C-C bond formation and stereocenter generation greatly minimizes the use of protecting groups and oxidation state changes, as compared to previously reported routes to similar fragments.
[Mh] Termos MeSH primário: Ácidos Graxos Insaturados/síntese química
Macrolídeos/química
[Mh] Termos MeSH secundário: Ácidos Graxos Insaturados/química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); 0 (Macrolides); 0 (biselyngbyolide B)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc08004b


  7 / 17774 MEDLINE  
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[PMID]:29287723
[Au] Autor:Yan J; Liang X; Cui Y; Cao X; Gao J
[Ad] Endereço:College of Fisheries, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education/Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China.
[Ti] Título:Elovl4 can effectively elongate C18 polyunsaturated fatty acids in loach Misgurnus anguillicaudatus.
[So] Source:Biochem Biophys Res Commun;495(4):2637-2642, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, full-length cDNA sequences of elovl4a and elovl4b from loach Misgurnus anguillicaudatus were cloned. The full-length cDNAs of loach elovl4a and elovl4b were 2423 and 2054bp, encoding 315 and 300 amino acids, respectively. The deduced amino acid sequences of elovl4a and elovl4b in loach both shared the highest identity with those of Danio rerio, whereas lower identity score between loach elovl4a and elovl4b was present. Temporal expression and tissue expression of loach elovl4a and elovl4b were studied by reverse transcriptase PCR. Results of the tissue expression analyses suggested different functions of loach elovl4a and elovl4b. Functional characterizations of loach elovl4a and elovl4b on synthesis of fatty acids, especially elongating C18 polyunsaturated fatty acids (PUFAs) to longer-chain fatty acids, were studied by heterologous expression in Saccharomyces cerevisiae. Loach elovl4a and elvol4b enzymes were able to elongate all fatty acids tested including 18:2n-6, 18:3n-3, 18:3n-6, 20:4n-6 and 20:5n-3. At last, expression levels of the two elovl4 genes of loach fin cells incubated with 18:2n-6 and 18:3n-3 of different concentrations were measured. Expressions of elovl4a and elovl4b of loach fin cells were significantly up-regulated by 18:2n-6 and 18:3n-3. The results obtained here indicated that loach elovl4 could effectively elongate C18 PUFAs. This was a systematic report of elovl4's elongating functions towards C18 and provided an alternative pathway for C20 biosynthesis in fish species.
[Mh] Termos MeSH primário: Acetiltransferases/química
Acetiltransferases/metabolismo
Cipriniformes/metabolismo
Ácidos Graxos Insaturados/química
Ácidos Graxos Insaturados/metabolismo
Metabolismo dos Lipídeos/fisiologia
[Mh] Termos MeSH secundário: Animais
Peso Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); EC 2.3.1.- (Acetyltransferases); EC 2.3.1.- (fatty acid elongases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  8 / 17774 MEDLINE  
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[PMID]:28744874
[Au] Autor:Broach JS; Ohs CL; Breen NE
[Ad] Endereço:Program of Fisheries and Aquatic Sciences, School of Forest Resources and Conservation, Institute of Food and Agricultural Sciences, University of Florida, 7922 NW 71st St, Gainesville, FL 32653, U.S.A.
[Ti] Título:Protracted volitional spawning of pinfish Lagodon rhomboides and changes in egg quality and fatty-acid composition throughout the spawning season.
[So] Source:J Fish Biol;91(3):806-817, 2017 Sep.
[Is] ISSN:1095-8649
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Spawning performance of pinfish Lagodon rhomboides without use of hormonal aids was monitored over an extended season. Nearly three million eggs were obtained from 75 spawns collected over a 90-day consecutive period from a single population of four brood fish (1M:1F). A mean ± s.d. batch fecundity of 30·27 ± 22·64 eggs g female was estimated with 98·0 ± 0·06% of the batch composed of floating eggs which were 1·04 ± 0·04 mm in diameter and 85·71 ± 27·59% fertile. Floating eggs successfully hatched 54·65 ± 29·13% of the time which yielded larvae that were 2·59 ± 0·24 mm in length. Fatty acids within floating eggs were largely represented by polyunsaturated fatty acids (45·30 ± 2·14% of total fatty acids) of which linoleic acid [(c18:2n-6cis) 3·49 ± 1·69% trifluoroacetic acid (TFA)] and docosahexaenoic acid (DHA) [(c22:6n-3) 28·47 ± 1·48% TFA] represented the majority of fatty acids for n-6 and n-3 polyunsaturated fatty acids, respectively. The strongest correlations between fatty acids and hatching success and larval survival to first feeding were observed for the DHA:EPA (eicosapentaenoic acid; c20:5n-3) ratio and total n-6 polyunsaturated fatty-acids levels, respectively. These data demonstrate potential for producers to rely on natural spawns for extensive egg production and provide a baseline for future development of natural spawning protocols of captive L. rhomboides.
[Mh] Termos MeSH primário: Óvulo/metabolismo
Perciformes/fisiologia
Comportamento Sexual Animal
[Mh] Termos MeSH secundário: Animais
Aquicultura
Ácidos Docosa-Hexaenoicos/metabolismo
Ácido Eicosapentaenoico/metabolismo
Ácidos Graxos Insaturados/metabolismo
Feminino
Óvulo/fisiologia
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); 25167-62-8 (Docosahexaenoic Acids); AAN7QOV9EA (Eicosapentaenoic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1111/jfb.13381


  9 / 17774 MEDLINE  
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[PMID]:29293603
[Au] Autor:Schori C; Agbaga MP; Brush RS; Ayyagari R; Grimm C; Samardzija M
[Ad] Endereço:Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
[Ti] Título:Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse.
[So] Source:PLoS One;13(1):e0190514, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mutations in the elongation of very long chain fatty acid 4 (ELOVL4) gene cause Stargardt macular dystrophy 3 (STGD3), a rare, juvenile-onset, autosomal dominant form of macular degeneration. Although several mouse models have already been generated to investigate the link between the three identified disease-causing mutations in the ELOVL4 gene, none of these models recapitulates the early-onset cone photoreceptor cell death observed in the macula of STGD3 patients. To address this specifically, we investigated the effect of mutant ELOVL4 in a mouse model with an all-cone retina. Hence, we bred mice carrying the heterozygously mutated Elovl4 gene on the R91W;Nrl-/- all-cone background and analyzed the retinal lipid composition, morphology, and function over the course of 1 year. We observed a reduction of total phosphatidylcholine-containing very long chain-polyunsaturated fatty acids (PC-VLC-PUFAs) by 39% in the R91W;Nrl-/-;Elovl4 mice already at 6 weeks of age with a pronounced decline of the longest forms of PC-VLC-PUFAs. Total levels of shorter-chain fatty acids (< C26) remained unaffected. However, this reduction in PC-VLC-PUFA content in the all-cone retina had no impact on morphology or function and did not accelerate retinal degeneration in the R91W;Nrl-/-;Elovl4 mice. Taken together, mutations in the ELOVL4 gene lead to cone degeneration in humans, whereas mouse models expressing the mutant Elovl4 show predominant rod degeneration. The lack of a phenotype in the all-cone retina expressing the mutant form of the protein supports the view that aberrant function of ELOVL4 is especially detrimental for rods in mice and suggests a more subtle role of VLC-PUFAs for cone maintenance and survival.
[Mh] Termos MeSH primário: Proteínas do Olho/genética
Proteínas de Membrana/genética
Células Fotorreceptoras Retinianas Cones/patologia
Deleção de Sequência
[Mh] Termos MeSH secundário: Animais
Eletrorretinografia
Proteínas do Olho/metabolismo
Ácidos Graxos Insaturados/metabolismo
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Knockout
Mutação
Reação em Cadeia da Polimerase em Tempo Real
Células Fotorreceptoras Retinianas Cones/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Elovl4 protein, mouse); 0 (Eye Proteins); 0 (Fatty Acids, Unsaturated); 0 (Membrane Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190514


  10 / 17774 MEDLINE  
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[PMID]:29209933
[Au] Autor:Villar G; Wolfson MD; Hefetz A; Grozinger CM
[Ad] Endereço:Department of Entomology, Center for Pollinator Research, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. gwv5020@psu.edu.
[Ti] Título:Evaluating the Role of Drone-Produced Chemical Signals in Mediating Social Interactions in Honey Bees (Apis mellifera).
[So] Source:J Chem Ecol;44(1):1-8, 2018 Jan.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pheromones play a critical role in shaping societies of social insects, including honey bees, Apis mellifera. While diverse functions have been ascribed to queen- and worker-produced compounds, few studies have explored the identity and function of male-produced (drone) compounds. However, several lines of evidence suggest that drones engage in a variety of social interactions inside and outside of the colony. Here we elucidate the chemical composition of extracts of the drone mandibular gland, and test the hypothesis that compounds produced in these glands, or a synthetic blend consisting of the six main compounds, mediate drone social interactions in and out of the colony. Drone mandibular glands primarily produce a blend of saturated, unsaturated and methyl branched fatty acids ranging in chain length from nonanoic to docosanoic acids, and both gland extracts and synthetic blends of these chemicals serve to attract drones outside of the hive, but do not attract workers inside the hive. These studies shed light on the role drones and drone-produced chemicals have on mediating social interactions with other drones and highlight their potential importance in communicating with other castes.
[Mh] Termos MeSH primário: Abelhas/fisiologia
Feromônios/química
[Mh] Termos MeSH secundário: Animais
Abelhas/química
Comportamento Animal/efeitos dos fármacos
Ácidos Graxos Insaturados/análise
Ácidos Graxos Insaturados/química
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Masculino
Feromônios/análise
Feromônios/farmacologia
Comportamento Social
Glândula Submandibular/química
Glândula Submandibular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); 0 (Pheromones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0912-2



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