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Pesquisa : D10.251.355.255.550.775.450.050 [Categoria DeCS]
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Fotocópia
[PMID]:11243226
[Au] Autor:Xu RM; Zhang SR; Jin BY; Han C; Wu YL
[Ad] Endereço:Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
[Ti] Título:[Antisecretory effect of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) on perfusing rats in vivo].
[So] Source:Yao Xue Xue Bao;32(1):79-80, 1997.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The antisecretion effect of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) was studied in perfusing rats in vivo. The results showed that PG6E at the dose 0.1 mg.kg-1 decreased markedly the acid secretion and antagonized the gastric acid secretion induced by histamine, pilocarpin and pentagastrin in rats. This action of PG6E appeared to be similar to that of cimetidine (40 mg.kg-1).
[Mh] Termos MeSH primário: Arbaprostilo/farmacologia
Ácido Gástrico/secreção
Fármacos Gastrointestinais/farmacologia
[Mh] Termos MeSH secundário: Animais
Arbaprostilo/análogos & derivados
Antagonistas dos Receptores Histamínicos
Masculino
Pentagastrina/antagonistas & inibidores
Pilocarpina/antagonistas & inibidores
Ratos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Agents); 0 (Histamine Antagonists); 01MI4Q9DI3 (Pilocarpine); 36210-00-1 (15-methylprostaglandin E2 methyl ester); EF0NX91490 (Pentagastrin); M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:0105
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970101
[St] Status:MEDLINE


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Fotocópia
[PMID]:9863242
[Au] Autor:Zhang SR; Xu RM; Jin BY; Wu YL; Han C
[Ad] Endereço:Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
[Ti] Título:[Protection of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) on experimental ulcers in rats].
[So] Source:Yao Xue Xue Bao;31(10):746-50, 1996.
[Is] ISSN:0513-4870
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The effects of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E), in experimental ulcers induced by absolute alcohol, HCl, indomethacin, pyloric ligation and chronic acetic acid in rats were studied. PG6E at doses 10-80 micrograms.kg-1 was shown to have significant protective effect. PG6E (30-60 micrograms.kg-1) was also found to reduce markedly the acid secretion, pepsin activity, DNA content of the juice collected from pylorus ligated stomach of rats and increase markedly the content of gastric mucosa hexosamine in mice given PG6E (30-60 micrograms.kg-1 po for 3 d). At doses of 40-80 micrograms.kg-1, PG6E was able to have no significant effect on gastric emptying time in rats and gastrointestinal tract movement in mice. It appears that PG6E was shown to inhibit the aggressive factors and increase the protective factors of gastric mucosa. This may hopefully become a new antiulcer agent.
[Mh] Termos MeSH primário: Antiulcerosos/farmacologia
Arbaprostilo/análogos & derivados
Ácido Gástrico/secreção
Úlcera Gástrica/metabolismo
[Mh] Termos MeSH secundário: Animais
Arbaprostilo/farmacologia
Feminino
Esvaziamento Gástrico/efeitos dos fármacos
Motilidade Gastrointestinal/efeitos dos fármacos
Masculino
Camundongos
Ratos
Ratos Wistar
Úlcera Gástrica/fisiopatologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 36210-00-1 (15-methylprostaglandin E2 methyl ester); M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:9902
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960101
[St] Status:MEDLINE


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Fotocópia
[PMID]:8270177
[Au] Autor:Takanashi H; Yogo K; Itoh-Inaba H; Akima M
[Ad] Endereço:Exploratory Research Laboratories III, Fujigotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
[Ti] Título:Comparative studies with 15(R)-15-methylprostaglandin E2 (arbaprostil) in rat femoral arterial preparations in vivo and in vitro.
[So] Source:Gen Pharmacol;24(5):1177-85, 1993 Sep.
[Is] ISSN:0306-3623
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. The vasodilator responses to 15(R)-15-methylprostaglandin E2 (arbaprostil), prostaglandin (PG) E2 and acetylcholine (ACh) administered into the femoral artery intra-arterial (i.a.) of anesthetized rats were attenuated by i.a. infusion of methylene blue, while that to nicardipine remained unaffected in the same dose-range of methylene blue. 2. The vasocontractor responses to arbaprostil and PGE2 in isolated femoral arterial strips were significantly potentiated by removal of the endothelium and the presence of NG-monomethyl L-arginine, while that to U-46619 remained unaffected under the same condition. 3. The present result indicates that the endothelium-dependent mechanism may play an important role in the vascular response to arbaprostil, like PGE2 and ACh.
[Mh] Termos MeSH primário: Arbaprostilo/farmacologia
Músculo Liso Vascular/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Animais
Arbaprostilo/administração & dosagem
Arbaprostilo/antagonistas & inibidores
Arginina/análogos & derivados
Arginina/farmacologia
Dinoprostona/farmacologia
Endotélio Vascular/fisiologia
Artéria Femoral/efeitos dos fármacos
Hemodinâmica/efeitos dos fármacos
Técnicas In Vitro
Injeções Intra-Arteriais
Masculino
Azul de Metileno/farmacologia
Óxido Nítrico/antagonistas & inibidores
Ratos
Ratos Sprague-Dawley
ômega-N-Metilarginina
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
27JT06E6GR (omega-N-Methylarginine); 31C4KY9ESH (Nitric Oxide); 94ZLA3W45F (Arginine); K7Q1JQR04M (Dinoprostone); M6B59S6MEF (Arbaprostil); N9YNS0M02X (Acetylcholine); T42P99266K (Methylene Blue)
[Em] Mês de entrada:9402
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930901
[St] Status:MEDLINE


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Fotocópia
[PMID]:1459349
[Au] Autor:Uribe A; Alam M; Midtvedt T
[Ad] Endereço:Department of Medicine, Danderyd Hospital, Sweden.
[Ti] Título:E2 prostaglandins modulate cell proliferation in the small intestinal epithelium of the rat.
[So] Source:Digestion;52(3-4):157-64, 1992.
[Is] ISSN:0012-2823
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Groups of Sprague-Dawley rats were administered 1 mg/kg indomethacin subcutaneously, indomethacin subcutaneously plus 200 micrograms/kg oral 15-R-15 methyl-prostaglandin E2 (MePGE2) or oral MePGE2 twice daily for 10 days. The animals were treated with antibiotics to prevent mortality. Two control groups were used: control 1 was given placebo and control 2 was treated with antibiotics. All rats were killed 4 h after injection of a metaphase blocker, and the proliferative activity of the distal small intestine was examined in histological sections by means of the cumulative mitotic index (MI). A reduction in the number of villous cells was observed in the rats given antibiotics (p < 0.05 vs. control 1). The small intestinal villi of the rats treated with indomethacin had fewer cells than those of both control groups (p < 0.05) whereas the crypts contained more cells (p < 0.05) and had a higher MI than those of the controls (p < 0.05 vs. controls 1 and 2). These changes were reverted by the prostaglandin analogue. The number of cells of the small intestinal crypts and the cumulative MI in the rats who received indomethacin and the prostaglandin analogue were similar to controls, and they were significantly lower than the values observed in the animals treated with indomethacin (p < 0.05). The animals treated with the prostaglandin analogue and placebo developed a marked hyperplasia of the small intestinal villi (p < 0.05 vs. both control groups), but the atrophy of the villi induced by indomethacin was not prevented by simultaneous administration of the analogue.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Dinoprostona/fisiologia
Mucosa Intestinal/citologia
Intestino Delgado/citologia
[Mh] Termos MeSH secundário: Animais
Arbaprostilo/farmacologia
Bacitracina/farmacologia
Divisão Celular/efeitos dos fármacos
Divisão Celular/fisiologia
Indometacina/farmacologia
Mucosa Intestinal/efeitos dos fármacos
Masculino
Índice Mitótico
Neomicina/farmacologia
Polimixina B/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1404-04-2 (Neomycin); 1404-26-8 (Polymyxin B); 1405-87-4 (Bacitracin); K7Q1JQR04M (Dinoprostone); M6B59S6MEF (Arbaprostil); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:9301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920101
[St] Status:MEDLINE


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Fotocópia
[PMID]:1434129
[Au] Autor:Takanashi H; Akima M
[Ad] Endereço:Department of Pharmacology, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
[Ti] Título:Protective effects of arbaprostil against indomethacin-induced gastric lesions in rats: significance of maintained gastric blood flow.
[So] Source:Jpn J Pharmacol;59(3):349-55, 1992 Jul.
[Is] ISSN:0021-5198
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The purpose of the present study was to investigate the relationship between the effects of 15(R)-15-methylprostaglandin E2 (arbaprostil) on gastric blood flow (GBF) and its protective effects on gastric lesions in rats. The GBF of anesthetized rats was measured by two different methods: Total blood flow into the stomach (total GBF) was determined by means of an ultrasonic pulsed Doppler flow meter; and gastric mucosal blood flow (mucosal GBF) was measured by nonradioactive microspheres. Systemic blood pressure (SBP), heart rate (HR) and gastric vascular resistance (GVR) were recorded simultaneously. Arbaprostil (10-100 micrograms/kg) given i.v. did not affect resting total or mucosal GBF even though it decreased SBP and GVR. Significant improvement of the total and mucosal GBF decreased by indomethacin pretreatment (10 mg/kg, i.v.) was observed by administration of arbaprostil (10-100 micrograms/kg, i.v.) in a dose-dependent manner. Furthermore, i.v.-administration of this agent, in the same dose-range, prevented the formation of gastric lesions induced by indomethacin. The present result suggests that mitigation for the ischemic state of the gastric mucosa may be one of the important mechanisms for the prophylactic and curative effect of arbaprostil on gastric lesions induced by indomethacin.
[Mh] Termos MeSH primário: Arbaprostilo/farmacologia
Mucosa Gástrica/irrigação sanguínea
Mucosa Gástrica/efeitos dos fármacos
Indometacina/farmacologia
[Mh] Termos MeSH secundário: Animais
Arbaprostilo/administração & dosagem
Pressão Sanguínea/efeitos dos fármacos
Relação Dose-Resposta a Droga
Frequência Cardíaca/efeitos dos fármacos
Injeções Intravenosas
Masculino
Ratos
Fluxo Sanguíneo Regional/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
M6B59S6MEF (Arbaprostil); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:9212
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920701
[St] Status:MEDLINE


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Fotocópia
[PMID]:1346556
[Au] Autor:Uribe A; Kapraali M; Grimelius L; Höög A
[Ad] Endereço:Dept. of Medicine, Danderyd Hospital, Stockholm, Sweden.
[Ti] Título:Trophic doses of E2 prostaglandins do not influence the exocrine and endocrine pancreas in the presence of high levels of plasma somatostatin.
[So] Source:Scand J Gastroenterol;27(1):33-8, 1992.
[Is] ISSN:0036-5521
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present investigation was to study the effect of a long-term and a short-term treatment regimen with 15-R-15-methyl prostaglandin E2 and natural prostaglandin E2 (PGE2) on the endocrine cell populations of the rat pancreas. Graded oral doses of the analogue (5 and 50 micrograms/kg) and PGE2 (5000 micrograms/kg) were given twice daily for 4 weeks. The pancreas was carefully excised and weighed. Sections from randomly taken pancreatic biopsy specimens were processed for immunohistochemistry or hematoxylin and eosin staining before quantitative estimations were made, using stereologic methods. The total pancreatic volumes of insulin-, glucagon-, polypeptide P-, somatostatin-, and chromogranin A-immunoreactive cells were not affected by E2 prostaglandins. Neither the total volume of the islets of Langerhans nor that of the pancreatic cell nuclei was affected. The size of pancreatic cell nuclei was the same in the groups. The plasma levels of the antitrophic peptide somatostatin were significantly increased in rats treated with doses of both the analogue and PGE2 (p less than 0.05). In an additional short-term study rats were given oral placebo or 5000 micrograms/kg PGE2 twice daily for 5 days. The total endocrine pancreatic volume was not affected by PGE2. As in the long-term study, natural PGE2 did not affect the total pancreas volume or the total volume of pancreatic cell nuclei. These findings indicate that E2 prostaglandins produce no changes in the exocrine or endocrine pancreas in a dose range known to induce hyperplasia in the gastrointestinal epithelium.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Arbaprostilo/farmacologia
Dinoprostona/farmacologia
Ilhotas Pancreáticas/efeitos dos fármacos
Pâncreas/efeitos dos fármacos
Somatostatina/sangue
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Contagem de Células/efeitos dos fármacos
Ilhotas Pancreáticas/citologia
Masculino
Pâncreas/citologia
Ratos
Ratos Endogâmicos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
51110-01-1 (Somatostatin); K7Q1JQR04M (Dinoprostone); M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:9203
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920101
[St] Status:MEDLINE


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Fotocópia
[PMID]:1813671
[Au] Autor:Takanashi H; Itoh Z
[Ad] Endereço:Department of Pharmacology, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
[Ti] Título:Gastric antisecretory activity of 15(R)-15-methylprostaglandin E2, arbaprostil, in dogs.
[So] Source:Jpn J Pharmacol;57(3):447-51, 1991 Nov.
[Is] ISSN:0021-5198
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The gastric antisecretory activity of 15(R)-15-methylprostaglandin E2 (arbaprostil) was compared with that of natural prostaglandin (PG) E2 in Pavlov pouch dogs. Arbaprostil significantly inhibited pentagastrin- and food-stimulated gastric secretion when it was administered directly into the pouch at a dose of 10-30 micrograms/pouch and 30-300 micrograms/pouch, respectively. Natural PGE2, however, was inactive up to 1000 micrograms/pouch. The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease.
[Mh] Termos MeSH primário: Arbaprostilo/farmacologia
Mucosa Gástrica/secreção
[Mh] Termos MeSH secundário: Animais
Arbaprostilo/efeitos adversos
Diarreia/induzido quimicamente
Dinoprostona/efeitos adversos
Dinoprostona/farmacologia
Cães
Ingestão de Alimentos/fisiologia
Feminino
Ácido Gástrico/secreção
Mucosa Gástrica/efeitos dos fármacos
Masculino
Pentagastrina/farmacologia
Nervo Vago/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
EF0NX91490 (Pentagastrin); K7Q1JQR04M (Dinoprostone); M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:9206
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:911101
[St] Status:MEDLINE


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Fotocópia
[PMID]:1803067
[Au] Autor:Takanashi H; Kawabe Y; Akima M
[Ad] Endereço:Department of Pharmacology, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
[Ti] Título:Acid-promoted epimerization of arbaprostil, 15(R)-15-methylprostaglandin E2, elicits gastric antisecretory activities in rats.
[So] Source:Jpn J Pharmacol;57(4):559-64, 1991 Dec.
[Is] ISSN:0021-5198
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Gastric acid antisecretory activities of 15(R)-15-methylprostaglandin E2 (arbaprostil) preincubated or not preincubated with 0.9% physiological saline, the pH of which was precisely adjusted to less than 4.30, were examined in pylorus-ligated rats, and compared with those of 15(S)-15-methylprostaglandin E2 (15(S), epimer of arbaprostil). 15(S), unlike arbaprostil without preincubation, when s.c.-administered to rats significantly inhibited gastric acid secretion in a dose-dependent manner (30-300 micrograms/kg). However, arbaprostil preincubated at 37 degrees C for 30 min with 0.9% saline, at pHs of 4.30, 2.75 and 1.20, respectively, showed the following order of pH-dependent antisecretory activities: 1.20 greater than 2.75 greater than 4.30. An increase in 15(S) formation from arbaprostil in a pH-dependent manner was also observed by radioisotopic experiments under the same incubation conditions using [3H]-labeled arbaprostil. The present result suggests that the gastric antisecretory effect of arbaprostil can be mainly explained in terms of the formation of 15(S) after oral administration.
[Mh] Termos MeSH primário: Arbaprostilo/administração & dosagem
Ácido Gástrico/secreção
[Mh] Termos MeSH secundário: Administração Oral
Animais
Arbaprostilo/química
Determinação da Acidez Gástrica
Concentração de Íons de Hidrogênio
Injeções Subcutâneas
Masculino
Distribuição Aleatória
Ratos
Ratos Endogâmicos
Estereoisomerismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:9204
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:911201
[St] Status:MEDLINE


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Fotocópia
[PMID]:2405642
[Au] Autor:Euler AR; Krawiec J; Odes H; Gilat T; Garcia L; Rachmilewitz D; Gabryelewicz A; Gibinski K; Bass D; Barbara L
[Ad] Endereço:Upjohn Company, Kalamazoo, MI 49001.
[Ti] Título:An evaluation of arbaprostil at multiple doses for the treatment of acute duodenal ulcer: a randomized double-blind placebo-controlled international trial.
[So] Source:Am J Gastroenterol;85(2):145-9, 1990 Feb.
[Is] ISSN:0002-9270
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six hundred and thirty patients were enrolled in a randomized double-blind placebo-controlled trial evaluating two arbaprostil dosages (25 micrograms and 50 micrograms) qid for 4 wk for the treatment of acute duodenal ulcers. The healing rates in the placebo, 25-micrograms, and 50-micrograms treatment groups were 39%, 51%, and 60%, respectively. Smoking was found to adversely affect the healing rates in all the treatment groups. Pain severity was less with either arbaprostil treatment. The only side effect found was diarrhea: 10%, 14%, and 32% in the placebo, 25-micrograms, and 50-micrograms treatment groups, respectively. Severe diarrhea occurred in 1% of those patients who received the 50-micrograms dosage regimen, but in none of the other two groups. Arbaprostil at these two dosage levels, when given for 4 wk, appears to be a safe and efficacious agent for the treatment of acute duodenal ulcers.
[Mh] Termos MeSH primário: Arbaprostilo/administração & dosagem
Úlcera Duodenal/tratamento farmacológico
Prostaglandinas E Sintéticas/administração & dosagem
[Mh] Termos MeSH secundário: Doença Aguda
Arbaprostilo/efeitos adversos
Cápsulas
Método Duplo-Cego
Úlcera Duodenal/sangue
Úlcera Duodenal/diagnóstico
Duodenoscopia
Feminino
Seres Humanos
Masculino
Estudos Multicêntricos como Assunto
Placebos
Ensaios Clínicos Controlados Aleatórios como Assunto
Fatores de Tempo
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Capsules); 0 (Placebos); 0 (Prostaglandins E, Synthetic); M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:9003
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900201
[St] Status:MEDLINE


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Fotocópia
[PMID]:2389058
[Au] Autor:Uribe A; Garberg L
[Ad] Endereço:Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
[Ti] Título:Prostaglandin E2-induced hyperplasia of the rat antral epithelium is followed by a secondary inhibition of the mitotic activity.
[So] Source:Prostaglandins;40(1):1-11, 1990 Jul.
[Is] ISSN:0090-6980
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to examine the mitotic activity in the antral and duodenal epithelium of Sprague-Dawley rats given trophic doses of E2 prostaglandins during a prolonged period of time. Natural prostaglandin E2 (dose range: 0.2-5.0 mg.k-1) and 15 (R) 15 methyl prostaglandin E2 (dose range: 0.03-2.0 mg.kg-1) were administered for 11 days, and mitoses were arrested with vincristine for 4 h before estimation of the cumulative mitotic index. A dose-related hyperplasia of the antral glands was observed after treatment with prostaglandin E2 and the synthetic analogue (p less than 0.05). The proliferative zone was enlarged in rats treated with high doses of the analogue but natural prostaglandin E2 did not affect the limits of the proliferative zone. A dose-related reduction of the mitotic index was observed in animals treated with prostaglandin E2 despite the presence of hyperplastic changes. All doses of the analogue induced antral hyperplasia without affecting the mitotic index except in rats given the highest dose who had a significantly lower mitotic index than controls (p less than 0.05). Hyperplasia of both crypts and villi was observed in the duodenum of rats given high doses of E2 prostaglandins (p less than 0.05) whereas the mitotic index and the growth fraction were not affected by treatments. It is concluded that hyperplasia by prostaglandins is developed in absence of changes of the mitotic activity. The observed reduction of the mitotic index is interpreted as a secondary phenomenon, possibly mediated by a regulatory mechanism of cell proliferation which is triggered to reduce further epithelial growth. It is suggested that prostaglandin E2 might influence such regulatory mechanisms.
[Mh] Termos MeSH primário: Arbaprostilo/toxicidade
Dinoprostona/toxicidade
Mitose/efeitos dos fármacos
Prostaglandinas E Sintéticas/toxicidade
Antro Pilórico/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Contagem de Células/efeitos dos fármacos
Duodeno/efeitos dos fármacos
Duodeno/patologia
Mucosa Gástrica/citologia
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/patologia
Hiperplasia/induzido quimicamente
Antro Pilórico/patologia
Ratos
Ratos Endogâmicos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Prostaglandins E, Synthetic); K7Q1JQR04M (Dinoprostone); M6B59S6MEF (Arbaprostil)
[Em] Mês de entrada:9009
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900701
[St] Status:MEDLINE



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