Base de dados : MEDLINE
Pesquisa : D10.251.355.310 [Categoria DeCS]
Referências encontradas : 3872 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 388 ir para página                         

  1 / 3872 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29245334
[Au] Autor:Chua CS; Huang SY; Cheng CW; Bai CH; Hsu CY; Chiu HW; Hsu JL
[Ad] Endereço:aGraduate Institute of Biomedical Informatics, Taipei Medical UniversitybDivision of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwancWestern Medicine Division, Hospital Lam Wah Ee, Penang, MalaysiadSchool of Nutrition and Health Sciences, Taipei Medical UniversityeDepartment of Transportation and Logistics Management, National Chiao Tung UniversityfDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical UniversitygSchool of Public Health, College of Public Health and Nutrition, Taipei Medical UniversityhDepartment of Information Management, National Taipei University of Nursing and Health SciencesiMaster Program in Global Health and Development, College of Public Health and Nutrition, Taipei Medical UniversityjDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, TaoyuankGraduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Fatty acid components in Asian female patients with irritable bowel syndrome.
[So] Source:Medicine (Baltimore);96(49):e9094, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS.The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS. However, because patterns in the oral intake of EFAs differ between cultures, the authors narrowed this study to examine the nutritional status of Asian female patients with IBSThe authors investigated Asian female patients with IBS and compared them with a group of healthy controls. Thirty patients with IBS and 39 healthy individuals were included in this study. The participants' age, height, weight, and waist size were recorded. The 24-item Hamilton Depression Rating Scale was documented. Both erythrocyte and plasma fatty acid content were analyzed through gas-liquid chromatography.The authors found that patients with IBS exhibited significantly higher scores for depression, higher proportions of plasma saturated fatty acids and monounsaturated fatty acids, and lower proportions of docosahexaenoic acid and total omega-3 polyunsaturated fatty acids in plasma are associated with IBS in Asian female patients. Further study is indicated to confirm the causality of this association.
[Mh] Termos MeSH primário: Depressão/epidemiologia
Ácidos Graxos/sangue
Síndrome do Intestino Irritável/sangue
Síndrome do Intestino Irritável/epidemiologia
[Mh] Termos MeSH secundário: Dor Abdominal/sangue
Adulto
Grupo com Ancestrais do Continente Asiático
Pesos e Medidas Corporais
Eritrócitos/metabolismo
Ácidos Graxos Essenciais
Ácidos Graxos Monoinsaturados/sangue
Ácidos Graxos Ômega-3/sangue
Ácidos Graxos Insaturados/sangue
Feminino
Seres Humanos
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Essential); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Omega-3); 0 (Fatty Acids, Unsaturated)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009094


  2 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28724657
[Au] Autor:Mridha MK; Matias SL; Paul RR; Hussain S; Sarker M; Hossain M; Peerson JM; Vosti SA; Dewey KG
[Ad] Endereço:Departments of Nutrition and mkmridha@ucdavis.edu.
[Ti] Título:Prenatal Lipid-Based Nutrient Supplements Do Not Affect Pregnancy or Childbirth Complications or Cesarean Delivery in Bangladesh: A Cluster-Randomized Controlled Effectiveness Trial.
[So] Source:J Nutr;147(9):1776-1784, 2017 Sep.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pregnancy and childbirth complications and cesarean delivery are common in Bangladesh. We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on pregnancy and childbirth complications and cesarean delivery. We conducted the Rang-Din Nutrition Study, a cluster-randomized controlled effectiveness trial within a community health program in rural Bangladesh. We enrolled 4011 pregnant women in early pregnancy. Women in 48 clusters received iron and folic acid (IFA; 60 mg Fe + 400 µg folic acid/d) and women in 16 clusters received LNS-PL (20 g/d, 118 kcal) containing essential fatty acids and 22 vitamins and minerals. Pregnancy and childbirth complications and the cesarean delivery rate were secondary outcomes of the study. Women in the LNS-PL group did not differ significantly from the IFA group with respect to mean systolic blood pressure at 36 wk gestation (113 and 112 mm Hg; = 0.17), diastolic blood pressure at 36 wk gestation (68.9 and 68.7 mmHg; = 0.88), or mean total number of pregnancy and childbirth complications (0.32 and 0.31; = 0.86). They also did not differ significantly with respect to the prevalence of high blood pressure at 36 wk (1.74% and 2.03%; = 0.62), antepartum hemorrhage (0.83% and 1.39%; = 0.21), prolonged labor (8.34% and 8.79%; = 0.68), early rupture of membranes (9.30% and 8.45%; = 0.43), convulsions (1.57% and 1.08%; = 0.24), high blood pressure in labor (1.54% and 1.19%; = 0.46), obstructed labor (2.83% and 2.91%; = 0.90), any complications during pregnancy or childbirth (35.9% and 37.1%; = 0.64), episiotomy (6.31% and 6.44%; = 0.90), or cesarean delivery (15.6% and 14.2%; = 0.48). Compared with IFA, antenatal LNS-PL did not increase or decrease pregnancy and childbirth complications or cesarean delivery among women in rural Bangladesh. This trial was registered at clinicaltrials.gov as NCT01715038.
[Mh] Termos MeSH primário: Cesárea
Suplementos Nutricionais
Ácidos Graxos Essenciais/farmacologia
Micronutrientes/farmacologia
Complicações na Gravidez
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bangladesh
Pressão Sanguínea
Episiotomia
Feminino
Hemorragia
Seres Humanos
Hipertensão Induzida pela Gravidez
Lipídeos/farmacologia
Fenômenos Fisiológicos da Nutrição Materna
Complicações do Trabalho de Parto
Gravidez
Ruptura
Convulsões
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Fatty Acids, Essential); 0 (Lipids); 0 (Micronutrients)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.248880


  3 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28686050
[Au] Autor:Wyer N
[Ad] Endereço:Senior Specialist Dietitian, University Hospitals Coventry and Warwickshire NHS Trust, Coventry.
[Ti] Título:Parenteral nutrition: indications and safe management.
[So] Source:Br J Community Nurs;22(Sup7):S22-S28, 2017 Jul 01.
[Is] ISSN:1462-4753
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this article is to provide an overview of what parenteral nutrition (PN) is and when its use is required. It will describe the process of nutritional assessment, and considerations when choosing venous access. The different approaches to provision of PN solutions in hospital will be discussed. Catheter-related and metabolic complications can occur during delivery of PN; there will be a discussion of the different types of complications and how these can be avoided or minimised. Finally, the pivotal role of the nurse in the assessment and ongoing care of patients who require PN will be highlighted, including skills required to administer PN safely.
[Mh] Termos MeSH primário: Enteropatias/terapia
Nutrição Parenteral/enfermagem
[Mh] Termos MeSH secundário: Infecções Relacionadas a Cateter
Cateteres Venosos Centrais
Ácidos Graxos Essenciais/deficiência
Seres Humanos
Hiperglicemia/etiologia
Hiperlipidemias/etiologia
Papel do Profissional de Enfermagem
Avaliação Nutricional
Nutrição Parenteral/efeitos adversos
Desequilíbrio Hidroeletrolítico/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Essential)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.12968/bjcn.2017.22.Sup7.S22


  4 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28577869
[Au] Autor:Gastón R; María Eugenia P; Das UN; Eynard AR
[Ad] Endereço:Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional Córdoba, Argentina; Cátedra de Histología y Embriología, Universidad Nacional de La Rioja, La Rioja, Argentina; INICSA, CONICET-UNC, Córdoba, Argentina.
[Ti] Título:Polyunsaturated Fatty Acids Differentially Modulate Cell Proliferation and Endocannabinoid System in Two Human Cancer Lines.
[So] Source:Arch Med Res;48(1):46-54, 2017 Jan.
[Is] ISSN:1873-5487
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Evidence suggests that quantity and quality of dietary polyunsaturated fatty acids (PUFAs) play a role in the development of cancer. However, the mechanisms involved in this interaction(s) are not clear. Endocannabinoids are lipid metabolites known to have growth modulatory actions. We studied the effect of supplementation with PUFAs ω-6 and ω-3 (essential fatty acids, EFAs), saturated and monounsaturated fatty acids (non-EFAs) on the growth of tumor cells and modifications in their endocannabinoid content. METHODS: Cell cultures of human glioblastoma (T98G) and breast cancer (MCF7) were supplemented with 50 or 100 mmol EFAs and non-EFAs for 72 h. Cell proliferation was then determined by MTT, anandamide (AEA) levels by HPLC, total fatty acids profiles by GLC, CB1 receptor expression by WB and FAAH activity by spectrophotometric method. RESULTS: Fatty acids profile reflected the incorporation of the lipids supplemented in each assay. Arachidonic acid (EFA ω-6) supplementation increased AEA levels and inhibited the growth of T98G, whereas palmitic acid (non-EFA) enhanced their proliferation. In breast cancer (MCF7) cells, eicosapentaenoic acid (EFA ω-3) reduced and oleic acid (non-EFA) enhanced their proliferation. CB1 expression was higher in T98G and no differences were observed in FAAH activity. CONCLUSIONS: The growth of tumor cells can be differentially modulated by fatty acids and, at least in part, can be attributed to their ability to act on the components of the endocannabinoid system.
[Mh] Termos MeSH primário: Endocanabinoides/metabolismo
Ácidos Graxos Insaturados/farmacologia
[Mh] Termos MeSH secundário: Ácidos Araquidônicos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Ácidos Graxos Essenciais/farmacologia
Seres Humanos
Metabolismo dos Lipídeos
Alcamidas Poli-Insaturadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arachidonic Acids); 0 (Endocannabinoids); 0 (Fatty Acids, Essential); 0 (Fatty Acids, Unsaturated); 0 (Polyunsaturated Alkamides); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


  5 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28500069
[Au] Autor:Kosaraju R; Guesdon W; Crouch MJ; Teague HL; Sullivan EM; Karlsson EA; Schultz-Cherry S; Gowdy K; Bridges LC; Reese LR; Neufer PD; Armstrong M; Reisdorph N; Milner JJ; Beck M; Shaikh SR
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834.
[Ti] Título:B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection.
[So] Source:J Immunol;198(12):4738-4752, 2017 Jun 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function. However, there is limited information about the influence of obesity on B cell function and underlying factors that modulate B cell responses. Therefore, we studied B cell cytokine secretion and/or Ab production across obesity models. In obese humans, B cell IL-6 secretion was lowered and IgM levels were elevated upon ex vivo anti-BCR/TLR9 stimulation. In murine obesity induced by a high fat diet, ex vivo IgM and IgG were elevated with unstimulated B cells. Furthermore, the high fat diet lowered bone marrow B cell frequency accompanied by diminished transcripts of early lymphoid commitment markers. Murine B cell responses were subsequently investigated upon influenza A/Puerto Rico/8/34 infection using a Western diet model in the absence or presence of docosahexaenoic acid (DHA). DHA, an essential fatty acid with immunomodulatory properties, was tested because its plasma levels are lowered in obesity. Relative to controls, mice consuming the Western diet had diminished Ab titers whereas the Western diet plus DHA improved titers. Mechanistically, DHA did not directly target B cells to elevate Ab levels. Instead, DHA increased the concentration of the downstream specialized proresolving lipid mediators (SPMs) 14-hydroxydocosahexaenoic acid, 17-hydroxydocosahexaenoic acid, and protectin DX. All three SPMs were found to be effective in elevating murine Ab levels upon influenza infection. Collectively, the results demonstrate that B cell responses are impaired across human and mouse obesity models and show that essential fatty acid status is a factor influencing humoral immunity, potentially through an SPM-mediated mechanism.
[Mh] Termos MeSH primário: Linfócitos B/imunologia
Ácidos Graxos Essenciais/imunologia
Imunidade Humoral
Interleucina-6/secreção
Obesidade/imunologia
Infecções por Orthomyxoviridae/imunologia
[Mh] Termos MeSH secundário: Animais
Dieta Ocidental
Modelos Animais de Doenças
Ácidos Docosa-Hexaenoicos/administração & dosagem
Ácidos Docosa-Hexaenoicos/sangue
Ácidos Docosa-Hexaenoicos/imunologia
Ácidos Graxos Essenciais/sangue
Seres Humanos
Imunoglobulina M/sangue
Vírus da Influenza A/imunologia
Interleucina-6/imunologia
Ativação Linfocitária
Camundongos
Obesidade/complicações
Infecções por Orthomyxoviridae/complicações
Receptor Toll-Like 9/imunologia
Receptor Toll-Like 9/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid); 0 (Fatty Acids, Essential); 0 (Immunoglobulin M); 0 (Interleukin-6); 0 (TLR9 protein, human); 0 (Toll-Like Receptor 9); 25167-62-8 (Docosahexaenoic Acids); 86360-66-9 (14-hydroxydocosahexaenoic acid); 90780-52-2 (17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601031


  6 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28382892
[Au] Autor:Pulakka A; Cheung YB; Maleta K; Dewey KG; Kumwenda C; Bendabenda J; Ashorn U; Ashorn P
[Ad] Endereço:1Department of Public Health,University of Turku and Turku University Hospital,20014 Turku,Finland.
[Ti] Título:Effect of 12-month intervention with lipid-based nutrient supplement on the physical activity of Malawian toddlers: a randomised, controlled trial.
[So] Source:Br J Nutr;117(4):511-518, 2017 Feb.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Physical activity is beneficial for children's well-being. The effect of dietary supplementation on children's physical activity in food-insecure areas remains little studied. We examined the effects of a lipid-based nutrient supplement (LNS) on children's objectively measured physical activity in a randomised, controlled, outcome-assessor-blinded trial. Mothers of the children received one capsule daily of Fe-folic acid (IFA), one capsule containing eighteen micronutrients (MMN) or one 20 g sachet of LNS (containing twenty-two MMN, protein, carbohydrates, essential fatty acids and 494 kJ (118 kcal)) during pregnancy and for 6 months thereafter. Children in the IFA and MMN groups received no supplementation, and these groups were collapsed into a single control group; children in the LNS group received 20 g LNS from 6 to 18 months. We measured physical activity with accelerometers over 1 week at 18 months. The main outcome was mean vector magnitude counts/15 s. Of the 728 children at the beginning of child intervention at 6 months, 570 (78 %) provided sufficient data for analysis. The mean accelerometer counts for the 190 children in the LNS group and for the 380 children in the control group were 303 (sd 59) and 301 (sd 56), respectively (P for difference=0·65). LNS, given to mothers during pregnancy and 6 months postpartum and to their infants from 6 to 18 months of age, did not increase physical activity among 18-month-old children.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Exercício
Ácidos Graxos Essenciais/farmacologia
Ácido Fólico/farmacologia
Ferro/farmacologia
Fenômenos Fisiológicos da Nutrição Materna
Micronutrientes/farmacologia
[Mh] Termos MeSH secundário: Acelerometria
Adulto
Feminino
Seres Humanos
Lactente
Comportamento do Lactente
Malaui
Masculino
Gravidez
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Fatty Acids, Essential); 0 (Micronutrients); 935E97BOY8 (Folic Acid); E1UOL152H7 (Iron)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000290


  7 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28316198
[Au] Autor:Liu Y; Liang QF
[Ad] Endereço:Beijing Tongren Hospital Capital Medical University, Beijing Tongren Eye center, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100005, China.
[Ti] Título:[Research update of effectiveness and mechanism of essential fatty acids in treating dry eye].
[So] Source:Zhonghua Yan Ke Za Zhi;53(3):225-229, 2017 Mar 11.
[Is] ISSN:0412-4081
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Topical anti-inflammatory therapy has become the significant way of treating dry eye so far. However, as the long-term use of routine anti-inflammatory medications are restricted from their side effects, it is inevitable to explore safer and more effective alternatives. Essential fatty acids have proven to be anti-inflammatory systemically, which makes it possible to treat dry eye. Clinical trials have demonstrated that supplementation with either ω-3 or ω-6 essential fatty acids or both has multifactorial efficacies including improvement of subjective symptoms, alleviation of inflammation of ocular surface and eyelid margin, prolongation of tear break-up time and increase of tear flow secretion. Besides anti-inflammation effects, several basic researches have revealed that other mechanisms of essential fatty acids treating dry eye might lie in the corneal epithelial healing and tear secretion promotion. This review puts emphasis on the effectiveness, feasibility and mechanism of treating dry eye with essential fatty acids. .
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Síndromes do Olho Seco/tratamento farmacológico
Ácidos Graxos Ômega-3/administração & dosagem
Ácidos Graxos Ômega-6/administração & dosagem
[Mh] Termos MeSH secundário: Córnea
Suplementos Nutricionais
Ácidos Graxos Essenciais/administração & dosagem
Estudos de Viabilidade
Seres Humanos
Pesquisa
Lágrimas
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Fatty Acids, Essential); 0 (Fatty Acids, Omega-3); 0 (Fatty Acids, Omega-6)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.03.019


  8 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28171706
[Au] Autor:Saville JT; Thai HN; Lehmann RJ; Derrick-Roberts AL; Fuller M
[Ad] Endereço:Genetics and Molecular Pathology, SA Pathology at Women's and Children's Hospital, North Adelaide, South Australia, Australia.
[Ti] Título:Subregional brain distribution of simple and complex glycosphingolipids in the mucopolysaccharidosis type I (Hurler syndrome) mouse: impact of diet.
[So] Source:J Neurochem;141(2):287-295, 2017 Apr.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gangliosides are the most complex oligosaccharide-containing glycosphingolipids defined by the presence of sialic acid and although present in all tissues, predominate in the brain. Considering their importance in neural development, it is unsurprising that ganglioside metabolism is altered in neurodegenerative diseases. The severe form of mucopolysaccharidosis type I, Hurler syndrome (HS), is characterised by progressive loss of neuronal function through largely undefined mechanisms. Here, we sought to interrogate brain gangliosides in a murine model of HS and further, assessed whether dietary modulation of lipid metabolism effected correction of the metabolic abnormalities. The simple gangliosides, G , G , G and G were elevated in the five subregions examined - brain stem, cerebellum, cortex, hippocampus, subcortex - in HS mice as early as 2 months of age compared with their wild type counterparts. Their elevation persisted at 6 months of age, imparting protracted neurological development as these simple gangliosides have usually subsided by this stage of brain development. Their immediate synthetic precursor, lactosylceramide, was also elevated, suggesting that their increase arises at this metabolic intermediary, as dihydroceramide, ceramide and monohexosylceramide were unaffected. Dietary linoleic acid supplementation significantly reduced G and G , and furthermore, improved exploratory behaviour as assessed by the open field test, highlighting the possibility of further exploring dietary intervention as a therapeutic consideration.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Dieta/métodos
Glicoesfingolipídeos/metabolismo
Ácido Linoleico/administração & dosagem
Mucopolissacaridose I/dietoterapia
Mucopolissacaridose I/metabolismo
[Mh] Termos MeSH secundário: Animais
Encéfalo/efeitos dos fármacos
Ácidos Graxos Essenciais/administração & dosagem
Feminino
Glicoesfingolipídeos/antagonistas & inibidores
Locomoção/efeitos dos fármacos
Locomoção/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Essential); 0 (Glycosphingolipids); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.13976


  9 / 3872 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28159082
[Au] Autor:Criscitelli T
[Ti] Título:Influencing Optimum Health for Nurses.
[So] Source:AORN J;105(2):228-231, 2017 Feb.
[Is] ISSN:1878-0369
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Estilo de Vida Saudável
Enfermeiras e Enfermeiros
Política Nutricional
[Mh] Termos MeSH secundário: Antioxidantes
Glicemia/análise
Água Potável/administração & dosagem
Ácidos Graxos Essenciais/administração & dosagem
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Drinking Water); 0 (Fatty Acids, Essential)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM; N
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


  10 / 3872 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28129764
[Au] Autor:Gunasekaran R; Shaker MR; Mohd-Zin SW; Abdullah A; Ahmad-Annuar A; Abdul-Aziz NM
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Maternal intake of dietary virgin coconut oil modifies essential fatty acids and causes low body weight and spiky fur in mice.
[So] Source:BMC Complement Altern Med;17(1):79, 2017 Jan 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coconut oil is commonly used as herbal medicine worldwide. There is limited information regarding its effects on the developing embryo and infant growth. METHODS: We investigated the effect of virgin coconut oil post-natally and until 6 weeks old in mice (age of maturity). Females were fed with either standard, virgin olive oil or virgin coconut oil diets 1 month prior to copulation, during gestation and continued until weaning of pups. Subsequently, groups of pups borne of the respective diets were continuously fed the same diet as its mother from weaning until 6 weeks old. Profiles of the standard and coconut oil diets were analysed by gas chromatography flame ionization detector (GCFID). RESULTS: Analysis of the mean of the total weight gained/ loss over 6 weeks revealed that in the first 3 weeks, pups whose mothers were fed virgin coconut oil and virgin olive oil have a significantly lower body weight than that of standard diet pups. At 6 weeks of age, only virgin coconut oil fed pups exhibited significantly lower body weight. We report that virgin coconut oil modifies the fatty acid profiles of the standard diet by inducing high levels of medium chain fatty acids with low levels of essential fatty acids. Furthermore, pups borne by females fed with virgin coconut oil developed spiky fur. CONCLUSION: Our study has demonstrated that virgin coconut oil could affect infant growth and appearance via maternal intake; we suggest the use of virgin coconut oil as herbal medicine to be treated with caution.
[Mh] Termos MeSH primário: Cocos/química
Dieta
Ácidos Graxos Essenciais/sangue
Cabelo/efeitos dos fármacos
Fenômenos Fisiológicos da Nutrição Materna
Óleos Vegetais/efeitos adversos
Ganho de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Óleo de Coco
Gorduras Insaturadas na Dieta/efeitos adversos
Gorduras Insaturadas na Dieta/sangue
Ácidos Graxos/análise
Comportamento Alimentar
Feminino
Camundongos Endogâmicos
Nozes/química
Óleos Vegetais/química
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats, Unsaturated); 0 (Fatty Acids); 0 (Fatty Acids, Essential); 0 (Plant Oils); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1600-z



página 1 de 388 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde