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[PMID]:28454732
[Au] Autor:Yang Z; Su Z; DeWitt JP; Xie L; Chen Y; Li X; Han L; Li D; Xia J; Zhang Y; Yang Y; Jin C; Zhang J; Li S; Li K; Zhang Z; Qu X; He Z; Chen Y; Shen Y; Ren M; Yuan Z
[Ad] Endereço:Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China. Electronic address: yangzuozhang@163.com.
[Ti] Título:Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy.
[So] Source:EBioMedicine;19:49-59, 2017 May.
[Is] ISSN:2352-3964
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bone is one of the most preferred sites of metastasis in lung cancer. Currently, bisphosphonates and denosumab are major agents for controlling tumor-associated skeletal-related events (SREs). However, both bisphosphonates and denosumab significantly increase the risk for jaw osteonecrosis. Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and the most frequently prescribed cholesterol-lowering agents, have been reported to inhibit tumor progression and induce autophagy in cancer cells. However, the effects of statin and role of autophagy by statin on bone metastasis are unknown. In this study, we report that fluvastatin effectively prevented lung adenocarcinoma bone metastasis in a nude mouse model. We further reveal that fluvastatin-induced anti-bone metastatic property was largely dependent on its ability to induce autophagy in lung adenocarcinoma cells. Atg5 or Atg7 deletion, or 3-methyadenine (3-MA) or Bafilomycin A1 (Baf A1) treatment prevented the fluvastatin-induced suppression of bone metastasis. Furthermore, we reveal that fluvastatin stimulation increased the nuclear p53 expression, and fluvastatin-induced autophagy and anti-bone metastatic activity were mostly dependent on p53.
[Mh] Termos MeSH primário: Adenocarcinoma/tratamento farmacológico
Antineoplásicos/uso terapêutico
Neoplasias Ósseas/prevenção & controle
Ácidos Graxos Monoinsaturados/uso terapêutico
Indóis/uso terapêutico
Neoplasias Pulmonares/tratamento farmacológico
[Mh] Termos MeSH secundário: Adenocarcinoma/metabolismo
Adenocarcinoma/patologia
Animais
Antineoplásicos/farmacologia
Autofagia/efeitos dos fármacos
Neoplasias Ósseas/metabolismo
Neoplasias Ósseas/secundário
Linhagem Celular Tumoral
Ácidos Graxos Monoinsaturados/farmacologia
Feminino
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia
Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico
Indóis/farmacologia
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/patologia
Camundongos Endogâmicos BALB C
Camundongos Nus
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Fatty Acids, Monounsaturated); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Indoles); 0 (Tumor Suppressor Protein p53); 4L066368AS (fluvastatin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:29416037
[Au] Autor:Zabara A; Chong JTY; Martiel I; Stark L; Cromer BA; Speziale C; Drummond CJ; Mezzenga R
[Ad] Endereço:Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9 LFO E23, 8092, Zürich, Switzerland.
[Ti] Título:Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains.
[So] Source:Nat Commun;9(1):544, 2018 02 07.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In meso crystallization of membrane proteins from lipidic mesophases is central to protein structural biology but limited to membrane proteins with small extracellular domains (ECDs), comparable to the water channels (3-5 nm) of the mesophase. Here we present a strategy expanding the scope of in meso crystallization to membrane proteins with very large ECDs. We combine monoacylglycerols and phospholipids to design thermodynamically stable ultra-swollen bicontinuous cubic phases of double-gyroid (Ia3d), double-diamond (Pn3m), and double-primitive (Im3m) space groups, with water channels five times larger than traditional lipidic mesophases, and showing re-entrant behavior upon increasing hydration, of sequences Ia3d→Pn3m→Ia3d and Pn3m→Im3m→Pn3m, unknown in lipid self-assembly. We use these mesophases to crystallize membrane proteins with ECDs inaccessible to conventional in meso crystallization, demonstrating the methodology on the Gloeobacter ligand-gated ion channel (GLIC) protein, and show substantial modulation of packing, molecular contacts and activation state of the ensued proteins crystals, illuminating a general strategy in protein structural biology.
[Mh] Termos MeSH primário: Membrana Celular
Proteínas de Membrana/química
Fosfatidilgliceróis/química
[Mh] Termos MeSH secundário: Cristalização/métodos
Ácidos Graxos Monoinsaturados/química
Canais Iônicos
Transição de Fase
Domínios Proteicos
Termodinâmica
Água
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids, Monounsaturated); 0 (Ion Channels); 0 (Membrane Proteins); 0 (Phosphatidylglycerols); 059QF0KO0R (Water); 4271ZA8WXO (distearoyl phosphatidylglycerol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-018-02996-5


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[PMID]:29247927
[Au] Autor:Tu X; Sun F; Wu S; Liu W; Gao Z; Huang S; Chen W
[Ad] Endereço:College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou, China; MOE Engineering Research Center of Bee Products Processing and Application, Fujian Agriculture and Forestry University, Fuzhou, China.
[Ti] Título:Comparison of salting-out and sugaring-out liquid-liquid extraction methods for the partition of 10-hydroxy-2-decenoic acid in royal jelly and their co-extracted protein content.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1073:90-95, 2018 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Homogeneous liquid-liquid extraction (h-LLE) has been receiving considerable attention as a sample preparation method due to its simple and fast partition of compounds with a wide range of polarities. To better understand the differences between the two h-LLE extraction approaches, salting-out assisted liquid-liquid extraction (SALLE) and sugaring-out assisted liquid-liquid extraction (SULLE), have been compared for the partition of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly, and for the co-extraction of proteins. Effects of the amount of phase partition agents and the concentration of acetonitrile (ACN) on the h-LLE were discussed. Results showed that partition efficiency of 10-HDA depends on the phase ratio in both SALLE and SULLE. Though the partition triggered by NaCl and glucose is less efficient than MgSO in the 50% (v/v) ACN-water mixture, their extraction yields can be improved to be similar with that in MgSO SALLE by increasing the initial concentration of ACN in the ACN-water mixture. The content of co-extracted protein was correlated with water concentration in the obtained upper phase. MgSO showed the largest protein co-extraction at the low concentration of salt. Glucose exhibited a large protein co-extraction in the high phase ratio condition. Furthermore, NaCl with high initial ACN concentration is recommended because it produced high extraction yield for 10-HDA and the lowest amount of co-extracted protein. These observations would be valuable for the sample preparation of royal jelly.
[Mh] Termos MeSH primário: Ácidos Graxos Monoinsaturados/isolamento & purificação
Ácidos Graxos/química
Glucose/química
Extração Líquido-Líquido/métodos
Proteínas/isolamento & purificação
Cloreto de Sódio/química
[Mh] Termos MeSH secundário: Acetonitrilos
Ácidos Graxos Monoinsaturados/análise
Proteínas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Proteins); 451W47IQ8X (Sodium Chloride); 765-01-5 (10-hydroxy-2-decenoic acid); IY9XDZ35W2 (Glucose); L497I37F0C (royal jelly); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29327928
[Au] Autor:Zhu ZJ; Chen HM; Chen JJ; Yang R; Yan XJ
[Ad] Endereço:Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University , Ningbo, Zhejiang 315211, China.
[Ti] Título:One-Step Bioconversion of Fatty Acids into C8-C9 Volatile Aroma Compounds by a Multifunctional Lipoxygenase Cloned from Pyropia haitanensis.
[So] Source:J Agric Food Chem;66(5):1233-1241, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The multifunctional lipoxygenase PhLOX cloned from Pyropia haitanensis was expressed in Escherichia coli with 24.4 mg·L yield. PhLOX could catalyze the one-step bioconversion of C18-C22 fatty acids into C8-C9 volatile organic compounds (VOCs), displaying higher catalytic efficiency for eicosenoic and docosenoic acids than for octadecenoic acids. C20:5 was the most suitable substrate among the tested fatty acids. The C8-C9 VOCs were generated in good yields from fatty acids, e.g., 2E-nonenal from C20:4, and 2E,6Z-nonadienal from C20:5. Hydrolyzed oils were also tested as substrates. The reactions mainly generated 2E,4E-pentadienal, 2E-octenal, and 2E,4E-octadienal from hydrolyzed sunflower seed oil, corn oil, and fish oil, respectively. PhLOX showed good stability after storage at 4 °C for 2 weeks and broad tolerance to pH and temperature. These desirable properties of PhLOX make it a promising novel biocatalyst for the industrial production of volatile aroma compounds.
[Mh] Termos MeSH primário: Ácidos Graxos/metabolismo
Lipoxigenase/genética
Lipoxigenase/metabolismo
Proteínas Recombinantes/metabolismo
Rodófitas/enzimologia
Compostos Orgânicos Voláteis/metabolismo
[Mh] Termos MeSH secundário: Clonagem Molecular
Óleo de Milho/metabolismo
Estabilidade Enzimática
Ácidos Erúcicos/metabolismo
Escherichia coli/genética
Ácidos Graxos Monoinsaturados/metabolismo
Óleos de Peixe/metabolismo
Expressão Gênica
Concentração de Íons de Hidrogênio
Rodófitas/genética
Especificidade por Substrato
Óleo de Girassol/metabolismo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Erucic Acids); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Fish Oils); 0 (Recombinant Proteins); 0 (Sunflower Oil); 0 (Volatile Organic Compounds); 8001-30-7 (Corn Oil); EC 1.13.11.12 (Lipoxygenase); UDX6WPL94T (eicosenoic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05341


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[PMID]:28740028
[Au] Autor:Watadani R; Kotoh J; Sasaki D; Someya A; Matsumoto K; Maeda A
[Ad] Endereço:Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan.
[Ti] Título:10-Hydroxy-2-decenoic acid, a natural product, improves hyperglycemia and insulin resistance in obese/diabetic KK-Ay mice, but does not prevent obesity.
[So] Source:J Vet Med Sci;79(9):1596-1602, 2017 Sep 29.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:10-Hydroxy-2-decenoic acid (10H2DA) is a fatty acid found in royal jelly (RJ). In healthy mice, it activates 5'-AMP-activated protein kinase (AMPK) and increases glucose transporter 4 (GLUT4) translocation. Therefore, we examined whether 10H2DA has a potential therapeutic effect against type 2 diabetes in obese/diabetic KK-Ay mice. 10H2DA (3 mg/kg body weight) was administered to female KK-Ay mice for 4 weeks by oral gavage. Phenotypes for body weight, plasma glucose by oral glucose tolerance test and insulin levels were measured. mRNA and protein levels were determined using qRT-PCR and Western blot analyses, respectively. Long-term administration of 10H2DA significantly improved hyperglycemia and insulin resistance in KK-Ay mice, but did not prevent obesity. 10H2DA increased the expression of phosphorylated AMPK (pAMPK) protein in skeletal muscles; however, this expression did not correlate with increased GLUT4 translocation. Furthermore, 10H2DA neither enhanced the expression of adiponectin receptor mRNA nor activated the insulin signaling cascade, such as GSK-3ß phosphorylation, in the liver. We found that 10H2DA-treated mice had a significant increase in the expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (Pgc-1α) mRNA in skeletal muscles compared with non-treated group (P=0.0024). These findings suggest that 10H2DA is involved in the improvement of type 2 diabetes, at least in part via activation of Pgc-1α expression, but does not prevent obesity.
[Mh] Termos MeSH primário: Ácidos Graxos Monoinsaturados/farmacologia
Hiperglicemia/tratamento farmacológico
Resistência à Insulina
Fígado/enzimologia
Obesidade/tratamento farmacológico
[Mh] Termos MeSH secundário: Adiponectina/classificação
Adiponectina/genética
Adiponectina/metabolismo
Tecido Adiposo/metabolismo
Animais
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Teste de Tolerância a Glucose
Homeostase
Fígado/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Fatty Acids, Monounsaturated); 0 (RNA, Messenger); 765-01-5 (10-hydroxy-2-decenoic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.17-0348


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[PMID]:28448961
[Au] Autor:Divya KP; Dharuman V
[Ad] Endereço:Molecular Electronics Laboratory, Department of Bioelectronics and Biosensors, Science Campus, Alagappa University, Karaikudi 630003, India.
[Ti] Título:Supported binary liposome vesicle-gold nanoparticle for enhanced label free DNA and protein sensing.
[So] Source:Biosens Bioelectron;95:168-173, 2017 Sep 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Supported binary liposome mixture of cationic liposome N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium propane (DOTAP) and the zwitterionic liposome 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) were tethered on thiol monolayers in the absence and presence of gold nanoparticle to enhance sensor stability and sensitivity for label free DNA and protein sensing for the first time. Cysteamine hydrochloride (Cyst), 3-Mercaptopropionic acid (MPA), 11-Mercaptoundecanoic acid (MUDA) and 11-amino-1-undecane thiol (AUT) monolayers were used as tethers on gold surfaces. Electrochemical studies in the presence of [Fe(CN) ] indicate that the presence of both DOPE and AuNP decreases the electrostatic interaction between DOTAP and MPA layer during the formation of DOPE-DOTAP-AuNP (DDA) whereas they enhance the repulsive force on the Cyst and AUT monolayers. In the thiol monolayer supported DDA, the gelation of neutral lipid DOPE by the AuNP is disfavored which inturn promotes stability of vesicle structure. The membrane protein melittin's interaction with the DDA indicates the presence of intact vesicle by showing decreased charge transfer for the MUDA and AUT in the presence of [Fe(CN) ] . On the contrary, the presence of the bilayer and semi circled DDA on the MPA and cysteamine layers were confirmed by the increased redox reaction. Atomic Force Microscopic (AFM) and Transmission Electron Microscopic (TEM) images support the presence of an array like semi circled DDA on the MPA and well separated DDA vesicles on the MUDA with variable sizes. Dynamic Light Scattering (DLS) and Fourier Transform Infrared spectroscopy (FTIR) suggest effective coordination between DOPE, DOTAP and AuNP. Label free DNA hybridization sensing in presence of the negatively charged [Fe(CN) ] indicates the lowest DNA detection limit of 1×10 M with linearity range 1×10 to 1×10 M. Similarly, streptavidin sensing shows the lowest detection of 1ngml with a linear range 100ng to 1µg due to the increased reactive sites and distance.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Ácidos Nucleicos Livres/isolamento & purificação
Lipossomos/química
Proteínas/isolamento & purificação
[Mh] Termos MeSH secundário: Ácido 3-Mercaptopropiônico
Ácidos Nucleicos Livres/química
Cisteamina/química
Ácidos Graxos Monoinsaturados/química
Ouro/química
Limite de Detecção
Lipídeos/química
Nanopartículas Metálicas/química
Microscopia de Força Atômica
Microscopia Eletrônica de Transmissão
Hibridização de Ácido Nucleico
Fosfatidiletanolaminas/química
Compostos de Amônio Quaternário/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell-Free Nucleic Acids); 0 (Fatty Acids, Monounsaturated); 0 (Lipids); 0 (Liposomes); 0 (Phosphatidylethanolamines); 0 (Proteins); 0 (Quaternary Ammonium Compounds); 2462-63-7 (dioleoyl phosphatidylethanolamine); 5UX2SD1KE2 (Cysteamine); 7440-57-5 (Gold); B03TJ3QU9M (3-Mercaptopropionic Acid); MR86K0XRQP (1,2-dioleoyloxy-3-(trimethylammonium)propane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:29337671
[Au] Autor:Stolarczyk M; Apola A; Maslanka A; Kwiecien A; Opoka W
[Ad] Endereço:1Department of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, Poland.
[Ti] Título:Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures.
[So] Source:Acta Pharm;67(4):463-478, 2017 Dec 20.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32.48 mg mL-1 for valsartan, 8.16-28.56 mg mL-1 f or fluvastatin, 14.40-39.90 mg mL-1 for atorvastatin and 9.60-48.00 mg mL-1 for pravastatin. Determination coefficients were in the range of 0.989-0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100 ± 5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.
[Mh] Termos MeSH primário: Inibidores de Hidroximetilglutaril-CoA Redutases/análise
Espectrofotometria/métodos
Valsartana/análise
[Mh] Termos MeSH secundário: Atorvastatina Cálcica/análise
Ácidos Graxos Monoinsaturados/análise
Indóis/análise
Pravastatina/análise
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Monounsaturated); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Indoles); 48A5M73Z4Q (Atorvastatin Calcium); 4L066368AS (fluvastatin); 80M03YXJ7I (Valsartan); KXO2KT9N0G (Pravastatin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


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[PMID]:29245334
[Au] Autor:Chua CS; Huang SY; Cheng CW; Bai CH; Hsu CY; Chiu HW; Hsu JL
[Ad] Endereço:aGraduate Institute of Biomedical Informatics, Taipei Medical UniversitybDivision of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwancWestern Medicine Division, Hospital Lam Wah Ee, Penang, MalaysiadSchool of Nutrition and Health Sciences, Taipei Medical UniversityeDepartment of Transportation and Logistics Management, National Chiao Tung UniversityfDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical UniversitygSchool of Public Health, College of Public Health and Nutrition, Taipei Medical UniversityhDepartment of Information Management, National Taipei University of Nursing and Health SciencesiMaster Program in Global Health and Development, College of Public Health and Nutrition, Taipei Medical UniversityjDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, TaoyuankGraduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Fatty acid components in Asian female patients with irritable bowel syndrome.
[So] Source:Medicine (Baltimore);96(49):e9094, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS.The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS. However, because patterns in the oral intake of EFAs differ between cultures, the authors narrowed this study to examine the nutritional status of Asian female patients with IBSThe authors investigated Asian female patients with IBS and compared them with a group of healthy controls. Thirty patients with IBS and 39 healthy individuals were included in this study. The participants' age, height, weight, and waist size were recorded. The 24-item Hamilton Depression Rating Scale was documented. Both erythrocyte and plasma fatty acid content were analyzed through gas-liquid chromatography.The authors found that patients with IBS exhibited significantly higher scores for depression, higher proportions of plasma saturated fatty acids and monounsaturated fatty acids, and lower proportions of docosahexaenoic acid and total omega-3 polyunsaturated fatty acids in plasma are associated with IBS in Asian female patients. Further study is indicated to confirm the causality of this association.
[Mh] Termos MeSH primário: Depressão/epidemiologia
Ácidos Graxos/sangue
Síndrome do Intestino Irritável/sangue
Síndrome do Intestino Irritável/epidemiologia
[Mh] Termos MeSH secundário: Dor Abdominal/sangue
Adulto
Grupo com Ancestrais do Continente Asiático
Pesos e Medidas Corporais
Eritrócitos/metabolismo
Ácidos Graxos Essenciais
Ácidos Graxos Monoinsaturados/sangue
Ácidos Graxos Ômega-3/sangue
Ácidos Graxos Insaturados/sangue
Feminino
Seres Humanos
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Essential); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Omega-3); 0 (Fatty Acids, Unsaturated)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009094


  9 / 5942 MEDLINE  
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[PMID]:29189192
[Au] Autor:Houghton SC; Manson JE; Whitcomb BW; Hankinson SE; Troy LM; Bigelow C; Bertone-Johnson ER
[Ad] Endereço:1Department of Biostatistics and Epidemiology,University of Massachusetts,Amherst,MA 01003,USA.
[Ti] Título:Intake of dietary fat and fat subtypes and risk of premenstrual syndrome in the Nurses' Health Study II.
[So] Source:Br J Nutr;118(10):849-857, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Approximately 8-20 % of reproductive-aged women experience premenstrual syndrome (PMS), substantially impacting quality of life. Women with PMS are encouraged to reduce fat intake to alleviate symptoms; however, its role in PMS development is unclear. We evaluated the association between dietary fat intake and PMS development among a subset of the prospective Nurses' Health Study II cohort. We compared 1257 women reporting clinician-diagnosed PMS, confirmed by premenstrual symptom questionnaire and 2463 matched controls with no or minimal premenstrual symptoms. Intakes of total fat, subtypes and fatty acids were assessed via FFQ. After adjustment for age, BMI, smoking, Ca and other factors, intakes of total fat, MUFA, PUFA and trans-fat measured 2-4 years before were not associated with PMS. High SFA intake was associated with lower PMS risk (relative risk (RR) quintile 5 (median=28·1 g/d) v. quintile 1 (median=15·1 g/d)=0·75; 95 % CI 0·58, 0·98; P trend=0·07). This association was largely attributable to stearic acid intake, with women in the highest quintile (median=7·4 g/d) having a RR of 0·75 v. those with the lowest intake (median=3·7 g/d) (95 % CI 0·57, 0·97; P trend=0·03). Individual PUFA and MUFA, including n-3 fatty acids, were not associated with risk. Overall, fat intake was not associated with higher PMS risk. High intake of stearic acid may be associated with a lower risk of developing PMS. Additional prospective research is needed to confirm this finding.
[Mh] Termos MeSH primário: Dieta
Gorduras na Dieta/farmacologia
Ácidos Graxos/farmacologia
Comportamento Alimentar
Síndrome Pré-Menstrual
[Mh] Termos MeSH secundário: Adulto
Gorduras na Dieta/efeitos adversos
Ácidos Graxos/efeitos adversos
Ácidos Graxos Monoinsaturados/efeitos adversos
Ácidos Graxos Insaturados/efeitos adversos
Feminino
Seres Humanos
Síndrome Pré-Menstrual/etiologia
Síndrome Pré-Menstrual/prevenção & controle
Estudos Prospectivos
Risco
Ácidos Esteáricos/efeitos adversos
Ácidos Esteáricos/farmacologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Unsaturated); 0 (Stearic Acids); 4ELV7Z65AP (stearic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002690


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[PMID]:28466134
[Au] Autor:Czaplicki S; Ogrodowska D; Zadernowski R; Konopka I
[Ad] Endereço:Chair of Plant Food Chemistry and Processing, Faculty of Food Sciences, University of Warmia and Mazury, Plac Cieszynski 1, 10-726, Olsztyn, Poland. selek@go2.pl.
[Ti] Título:Effect of Sea-Buckthorn (Hippophaë rhamnoides L.) Pulp Oil Consumption on Fatty Acids and Vitamin A and E Accumulation in Adipose Tissue and Liver of Rats.
[So] Source:Plant Foods Hum Nutr;72(2):198-204, 2017 Jun.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An in vivo experiment was conducted to determine the effect of sea-buckthorn pulp oil feeding on the fatty acid composition of liver and adipose tissue of Wistar rats and the liver accumulation of retinol, its esters and α-tocopherol. For a period of 28 days, rats were given a modified casein diet (AIN-93) in which sea-buckthorn pulp oil, soybean oil and pork lard were used as sources of fat. Compared to the other fat sources, sea-buckthorn pulp oil was the most abundant in C16 fatty acids, carotenoids (mainly ß-carotene) and tocopherols (mainly α-tocopherol). Its consumption was reflected in an increased share of palmitoleic acid in adipose tissue and the liver and an increased level of retinol in liver tissues (this was not observed for its esters). Although the type of fat did not have a significant effect on the average content of α-tocopherol in the liver, the variation of saturation of this tissue with α-tocopherol was the lowest when rats were fed a diet containing sea-buckthorn oil. This experiment indicates the possibility of affecting adipose tissue and liver by a diet.
[Mh] Termos MeSH primário: Ácidos Graxos/metabolismo
Hippophae/química
Óleos Vegetais/metabolismo
Vitamina A/metabolismo
Vitamina E/metabolismo
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Carotenoides/metabolismo
Gorduras na Dieta/metabolismo
Ácidos Graxos Monoinsaturados/metabolismo
Fígado/metabolismo
Masculino
Óleos Vegetais/química
Ratos
Ratos Wistar
Óleo de Soja/metabolismo
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Fatty Acids); 0 (Fatty Acids, Monounsaturated); 0 (Plant Oils); 11103-57-4 (Vitamin A); 1406-18-4 (Vitamin E); 209B6YPZ4I (palmitoleic acid); 36-88-4 (Carotenoids); 8001-22-7 (Soybean Oil); SI6O3IW77Z (lard)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-017-0610-9



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