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[PMID]:29311522
[Au] Autor:Matthäus B; Özcan MM; Juhaimi FA; Adiamo OQ; Alsawmahi ON; Ghafoor K; Babiker EE
[Ad] Endereço:Max Rubner-Institut (MRI) Bundesforschungsinstitut für Ernährung und Lebensmittel Institut für Sicherheit und Qualität bei GetreideSchützenberg.
[Ti] Título:Effect of the Harvest Time on Oil Yield, Fatty Acid, Tocopherol and Sterol Contents of Developing Almond and Walnut Kernels.
[So] Source:J Oleo Sci;67(1):39-45, 2018.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Oil content and bioactive properties of almond and walnut kernels were investigated in developing almond and walnut kernels at 10 days intervals. The oil contents of almond and walnuts after the first harvest (1.H) stage changed between 46.2% and 55.0% to 39.1% and 70.5%, respectively (p<0.05). Oleic acid contents of almond and walnut oils ranged from 71.98% (1.H) to 78.68% (5.H) and 10.51% (1.H) to 16.78% (2.H) depending on harvest (H) times, respectively (p<0.05). In addition, linolenic acid contents of walnut and almond oils were found between 62.35% and 67.78%, and 12.02% and 17.65%, respectively. The almond kernel oil after the first harvest stage contained 1.045, 1.058, 1.018, 0.995 and 0.819 mg/kg É‘-tocopherol, respectively. γ-Tocopherol contents of walnut oil changed between 1.364 (3.H) and 2.954 mg/kg (1.H). The ß-sitosterol contents of both almond and walnut oils were found between 1956.6 (5.H) and 2557.7 (1.H), and 1192.1 (3.H) and 4426.4 mg/kg (1.H). The study exhibited the presence of high percentage of oleic and linoleic for almond and walnut, respectively, and γ-tocopherol and ß-sitosterol.
[Mh] Termos MeSH primário: Produtos Agrícolas/química
Juglans/química
Ácidos Oleicos/análise
Óleos Vegetais/análise
Prunus dulcis/química
Sitosteroides/análise
Ácido alfa-Linolênico/análise
alfa-Tocoferol/análise
gama-Tocoferol/análise
[Mh] Termos MeSH secundário: Cromatografia Gasosa
Cromatografia Líquida de Alta Pressão
Óleos Vegetais/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oleic Acids); 0 (Plant Oils); 0 (Sitosterols); 0RBV727H71 (alpha-Linolenic Acid); 5LI01C78DD (gamma-sitosterol); 66YXD4DKO9 (almond oil); 8EF1Z1238F (gamma-Tocopherol); H4N855PNZ1 (alpha-Tocopherol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17162


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[PMID]:29305859
[Au] Autor:Zhao Y; Liu Y; Jing Z; Peng L; Jin P; Lin Y; Zhou Y; Yang L; Ren J; Xie Q; Jin X
[Ad] Endereço:Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen 361000, PR China.
[Ti] Título:N-oleoylethanolamide suppresses intimal hyperplasia after balloon injury in rats through AMPK/PPARα pathway.
[So] Source:Biochem Biophys Res Commun;496(2):415-421, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events in the pathological course of restenosis after percutaneous coronary intervention (PCI). N-oleoylethanolamide (OEA) is a bioactive lipid amide released upon dietary fat digestion with many reported actions. However, the effect of OEA on restenosis after vascular injury remains unknown. Here, we investigated the effects of OEA on intimal hyperplasia after balloon injury in vivo, its effect on VSMC proliferation and migration induced by platelet-derived growth factor (PDGF) stimulation in vitro, and the underlying mechanism underlying these effects. The results showed that OEA-treated rats displayed a significant reduction in neointima formation after balloon injury. In cultured VSMCs, treatment with OEA decreased cell proliferation and migration induced by PDGF. OEA treatment both in vivo and in vitro led to an increase in adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and peroxisome proliferator-activated receptor alpha (PPARα), and a decrease in proliferating cell nuclear antigen (PCNA) and cyclinD1 expression. Pharmacological inhibition of AMPK and PPARα reversed the suppressive effects of OEA on VSMC proliferation and migration, suggesting that the suppressive effect of OEA on VSMC proliferation and migration is mediated through the activation of AMPK and PPARα. In conclusion, our present study demonstrated that OEA attenuated neointima formation in response to balloon injury by suppressing SMC proliferation and migration through an AMPK and PPARα-dependent mechanism. Our data suggests that OEA may be a potential therapeutic agent for restenosis after PCI.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/genética
Fármacos Cardiovasculares/farmacologia
Lesões das Artérias Carótidas/tratamento farmacológico
Endocanabinoides/farmacologia
Hiperplasia/prevenção & controle
Neointima/prevenção & controle
Ácidos Oleicos/farmacologia
PPAR alfa/genética
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/metabolismo
Animais
Lesões das Artérias Carótidas/genética
Lesões das Artérias Carótidas/metabolismo
Lesões das Artérias Carótidas/patologia
Artéria Carótida Primitiva/efeitos dos fármacos
Artéria Carótida Primitiva/metabolismo
Artéria Carótida Primitiva/patologia
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Ciclina D1/genética
Ciclina D1/metabolismo
Células Endoteliais/efeitos dos fármacos
Células Endoteliais/metabolismo
Células Endoteliais/patologia
Hiperplasia/genética
Hiperplasia/metabolismo
Hiperplasia/patologia
Masculino
Músculo Liso Vascular/efeitos dos fármacos
Músculo Liso Vascular/metabolismo
Músculo Liso Vascular/patologia
Neointima/genética
Neointima/metabolismo
Neointima/patologia
PPAR alfa/metabolismo
Fosforilação
Fator de Crescimento Derivado de Plaquetas/antagonistas & inibidores
Fator de Crescimento Derivado de Plaquetas/farmacologia
Cultura Primária de Células
Antígeno Nuclear de Célula em Proliferação/genética
Antígeno Nuclear de Célula em Proliferação/metabolismo
Ratos
Ratos Sprague-Dawley
Túnica Íntima/efeitos dos fármacos
Túnica Íntima/metabolismo
Túnica Íntima/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cardiovascular Agents); 0 (Ccnd1 protein, rat); 0 (Endocannabinoids); 0 (Oleic Acids); 0 (PPAR alpha); 0 (Platelet-Derived Growth Factor); 0 (Proliferating Cell Nuclear Antigen); 0 (oleoylethanolamide); 136601-57-5 (Cyclin D1); EC 2.7.11.31 (AMP-Activated Protein Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE


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[PMID]:29244816
[Au] Autor:Avila-Martin G; Mata-Roig M; Galán-Arriero I; Taylor JS; Busquets X; Escribá PV
[Ad] Endereço:Hospital Nacional de Parapléjicos, Toledo, Spain.
[Ti] Título:Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation.
[So] Source:PLoS One;12(12):e0189151, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sensorimotor dysfunction following incomplete spinal cord injury (SCI) is often characterized by paralysis, spasticity and pain. Previously, we showed that intrathecal (i.t.) administration of the albumin-oleic acid (A-OA) complex in rats with SCI produced partial improvement of these symptoms and that oral 2-hydroxyoleic acid (HOA, a non-hydrolyzable OA analogue), was efficacious in the modulation and treatment of nociception and pain-related anxiety, respectively. Here we observed that intrathecal treatment with the complex albumin-HOA (A-HOA) every 3 days following T9 spinal contusion injury improved locomotor function assessed with the Rotarod and inhibited TA noxious reflex activity in Wistar rats. To investigate the mechanism of action of A-HOA, microarray analysis was carried out in the spinal cord lesion area. Representative genes involved in pain and neuroregeneration were selected to validate the changes observed in the microarray analysis by quantitative real-time RT-PCR. Comparison of the expression between healthy rats, SCI rats, and SCI treated with A-HOA rats revealed relevant changes in the expression of genes associated with neuronal morphogenesis and growth, neuronal survival, pain and inflammation. Thus, treatment with A-HOA not only induced a significant overexpression of growth and differentiation factor 10 (GDF10), tenascin C (TNC), aspirin (ASPN) and sushi-repeat-containing X-linked 2 (SRPX2), but also a significant reduction in the expression of prostaglandin E synthase (PTGES) and phospholipases A1 and A2 (PLA1/2). Currently, SCI has very important unmet clinical needs. A-HOA downregulated genes involved with inflammation and upregulated genes involved in neuronal growth, and may serve to promote recovery of function after experimental SCI.
[Mh] Termos MeSH primário: Albuminas/farmacologia
Ácidos Oleicos/farmacologia
Dor/prevenção & controle
Paralisia/tratamento farmacológico
Recuperação de Função Fisiológica/efeitos dos fármacos
Traumatismos da Medula Espinal/tratamento farmacológico
[Mh] Termos MeSH secundário: Albuminas/química
Animais
Esquema de Medicação
Proteínas da Matriz Extracelular/agonistas
Proteínas da Matriz Extracelular/genética
Proteínas da Matriz Extracelular/metabolismo
Regulação da Expressão Gênica
Fator 10 de Diferenciação de Crescimento/agonistas
Fator 10 de Diferenciação de Crescimento/genética
Fator 10 de Diferenciação de Crescimento/metabolismo
Injeções Espinhais
Locomoção/efeitos dos fármacos
Locomoção/fisiologia
Masculino
Proteínas do Tecido Nervoso/agonistas
Proteínas do Tecido Nervoso/genética
Proteínas do Tecido Nervoso/metabolismo
Nociceptividade/efeitos dos fármacos
Ácidos Oleicos/química
Dor/genética
Dor/metabolismo
Dor/patologia
Paralisia/genética
Paralisia/metabolismo
Paralisia/patologia
Fosfolipases/antagonistas & inibidores
Fosfolipases/genética
Fosfolipases/metabolismo
Prostaglandina-E Sintases/antagonistas & inibidores
Prostaglandina-E Sintases/genética
Prostaglandina-E Sintases/metabolismo
Ratos
Ratos Wistar
Recuperação de Função Fisiológica/fisiologia
Teste de Desempenho do Rota-Rod
Medula Espinal/efeitos dos fármacos
Medula Espinal/metabolismo
Medula Espinal/patologia
Traumatismos da Medula Espinal/genética
Traumatismos da Medula Espinal/metabolismo
Traumatismos da Medula Espinal/patologia
Tenascina/agonistas
Tenascina/genética
Tenascina/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-hydroxyoleic acid); 0 (Albumins); 0 (Extracellular Matrix Proteins); 0 (Gdf10 protein, rat); 0 (Growth Differentiation Factor 10); 0 (Nerve Tissue Proteins); 0 (Oleic Acids); 0 (Tenascin); 0 (asporin protein, rat); EC 3.1.- (Phospholipases); EC 5.3.99.3 (Prostaglandin-E Synthases); EC 5.3.99.3 (Ptges protein, rat)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189151


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[PMID]:28637686
[Au] Autor:Akter S; Kurotani K; Sato M; Hayashi T; Kuwahara K; Matsushita Y; Nakagawa T; Konishi M; Honda T; Yamamoto S; Hayashi T; Noda M; Mizoue T
[Ad] Endereço:Departments of Epidemiology and Prevention and samimarub@yahoo.com.
[Ti] Título:High Serum Phospholipid Dihomo-γ-Linoleic Acid Concentration and Low Δ5-Desaturase Activity Are Associated with Increased Risk of Type 2 Diabetes among Japanese Adults in the Hitachi Health Study.
[So] Source:J Nutr;147(8):1558-1566, 2017 Aug.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The association between the circulating fatty acid (FA) composition and type 2 diabetes (T2D) has been reported in Western populations, but evidence is scarce among Asian populations, including Japanese, who consume large amounts of fish. The objective of the present study was to prospectively examine the association between circulating concentrations of individual FAs and T2D incidence among Japanese adults. We conducted a nested case-control study in a cohort of 4754 employees, aged 34-69 y, who attended a comprehensive health checkup in 2008-2009 and donated blood samples for the Hitachi Health Study. During 5 y of follow-up, diabetes was identified on the basis of plasma glucose, glycated hemoglobin, and self-report. Two controls matched to each case by sex, age, and date of checkup were randomly chosen by using density sampling, resulting in 336 cases and 678 controls with FA measurements. GC was used to measure the FA composition in serum phospholipids. Cox proportional hazards regression was used to estimate the HRs and 95% CIs after adjusting for potential confounders. We examined the association of T2D risk with 25 different individual and combinations of FAs. T2D risk was positively associated with serum dihomo-γ-linoleic acid concentration (highest compared with the lowest quartile-HR: 1.49; 95% CI: 1.04, 2.11; trend = 0.02) and inversely associated with Δ5-desaturase activity (highest compared with the lowest quartile-HR: 0.72; 95% CI: 0.52, 0.99; trend = 0.02), independent of body mass index (BMI). There were also inverse associations between T2D risk with serum total n-6 (ω-6) polyunsaturated fatty acids (PUFAs), linoleic acid, and -vaccenic acid, but these were attenuated and became nonsignificant after adjustment for BMI. Serum n-3 (ω-3) PUFAs and saturated fatty acids (SFAs) were not associated with T2D risk. T2D risk was associated with circulating concentrations of the n-6 PUFA dihomo-γ-linoleic acid and Δ5-desaturase activity but not with n-3 PUFA or SFA concentrations in Japanese adults.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/sangue
Ácidos Graxos Dessaturases/sangue
Fosfolipídeos/química
Ácido gama-Linolênico/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Estudos de Coortes
Ácidos Graxos/sangue
Ácidos Graxos Ômega-3/sangue
Feminino
Seres Humanos
Incidência
Japão
Masculino
Meia-Idade
Ácidos Oleicos/sangue
Fosfolipídeos/sangue
Modelos de Riscos Proporcionais
Estudos Prospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Omega-3); 0 (Oleic Acids); 0 (Phospholipids); 506-17-2 (cis-vaccenic acid); 78YC2MAX4O (gamma-Linolenic Acid); EC 1.14.19.- (Fatty Acid Desaturases); EC 1.14.99.- (delta-5 fatty acid desaturase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.248997


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[PMID]:28622574
[Au] Autor:Veenstra KA; Wang T; Alnabulsi A; Douglas A; Russell KS; Tubbs L; Arous JB; Secombes CJ
[Ad] Endereço:Scottish Fish Immunology Research Centre, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK. Electronic address: k.veenstra@abdn.ac.uk.
[Ti] Título:Analysis of adipose tissue immune gene expression after vaccination of rainbow trout with adjuvanted bacterins reveals an association with side effects.
[So] Source:Mol Immunol;88:89-98, 2017 Aug.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Most existing fish vaccines are presented in the form of oil-based emulsions delivered by intraperitoneal injection. Whilst very effective they are frequently associated with inflammatory responses that can result in clinically significant side-effects often involving the adipose tissue that is in direct contact with the vaccine. To explore the potential of immune gene expression changes in the adipose tissue of fish to be markers of vaccination efficacy or development of side-effects we have studied the response to a bacterial (Aeromonas salmonicida) vaccine administered with two different adjuvants. The first adjuvant was Montanide™ ISA 763A VG, thought to induce a mostly humoral response, and the second was Montanide™ ISA 761 VG that gives a more balanced humoral and cell mediated response. Following vaccination tissue samples were collected at days 3, 14 and 28 for RTqPCR analysis. Fifty immune genes were studied with a focus on a) pro-inflammatory associated molecules and b) adaptive immune response related molecules linked with possible Th1, Th2, Th17 and T-regulatory pathways, with the expression data analysed for associations with Speilberg post-vaccination side effect scores. The results showed that the adipose tissue is a particularly sensitive and discriminatory tissue for studying adjuvant effects. A clear upregulation of many immune genes occurred in response to both vaccine groups, which persisted over time and overlapped with the appearance of visible adhesions. Our analysis revealed a relationship between adipose tissue immune function and the development of vaccine-induced adhesions giving the potential to use immune gene expression profiling in this tissue to predict the side-effects seen.
[Mh] Termos MeSH primário: Tecido Adiposo/imunologia
Adjuvantes Imunológicos/farmacologia
Oncorhynchus mykiss/imunologia
Vacinação/efeitos adversos
[Mh] Termos MeSH secundário: Aeromonas salmonicida/imunologia
Animais
Vacinas Bacterianas/imunologia
Doenças dos Peixes/imunologia
Doenças dos Peixes/microbiologia
Doenças dos Peixes/prevenção & controle
Furunculose/imunologia
Furunculose/microbiologia
Furunculose/prevenção & controle
Inflamação/imunologia
Manitol/análogos & derivados
Manitol/farmacologia
Ácidos Oleicos/imunologia
Ácidos Oleicos/farmacologia
Linfócitos T Reguladores/imunologia
Células Th1/imunologia
Células Th17/imunologia
Células Th2/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Bacterial Vaccines); 0 (Oleic Acids); 3OWL53L36A (Mannitol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE


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[PMID]:28495596
[Au] Autor:Galán-Arriero I; Serrano-Muñoz D; Gómez-Soriano J; Goicoechea C; Taylor J; Velasco A; Ávila-Martín G
[Ad] Endereço:Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain. Electronic address: igalan@jccm.es.
[Ti] Título:The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma.
[So] Source:Biochim Biophys Acta;1859(9 Pt B):1629-1635, 2017 09.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Omega-3 polyunsaturated fatty acids (PUFAs), such as docosaexaenoic acid (DHA) and eicosapentaenoic acid (EPA), mediate neuroactive effects in experimental models of traumatic peripheral nerve and spinal cord injury. Cellular mechanisms of PUFAs include reduced neuroinflammation and oxidative stress, enhanced neurotrophic support, and activation of cell survival pathways. Bioactive Omega-9 monounsaturated fatty acids, such as oleic acid (OA) and 2-hydroxy oleic acid (2-OHOA), also show therapeutic effects in neurotrauma models. These FAs reduces noxious hyperreflexia and pain-related anxiety behavior following peripheral nerve injury and improves sensorimotor function following spinal cord injury (SCI), including facilitation of descending inhibitory antinociception. The relative safe profile of neuroactive fatty acids (FAs) holds promise for the future clinical development of these molecules as analgesic agents. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá.
[Mh] Termos MeSH primário: Ácidos Graxos Monoinsaturados/uso terapêutico
Ácidos Graxos Ômega-3/uso terapêutico
Neuralgia/tratamento farmacológico
Traumatismos dos Nervos Periféricos/tratamento farmacológico
Traumatismos da Medula Espinal/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
Ácido Oleico/uso terapêutico
Ácidos Oleicos/uso terapêutico
Traumatismos dos Nervos Periféricos/complicações
Traumatismos da Medula Espinal/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (2-hydroxyoleic acid); 0 (Fatty Acids, Monounsaturated); 0 (Fatty Acids, Omega-3); 0 (Oleic Acids); 2UMI9U37CP (Oleic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


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[PMID]:28381775
[Au] Autor:Chaari A; Neji SB; Frikha MH
[Ad] Endereço:Laboratory of Natural Substances, Faculty of Sciences, University of Sfax.
[Ti] Título:Fatty Acid Esterification with Polyols over Acidic Montmorillonite.
[So] Source:J Oleo Sci;66(5):455-461, 2017 May 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The production of fatty acid esters from stearic, oleic, and palmitic acids and polyols (ethylene glycol and glycerol) was investigated in this work. A series of montmorillonite-based clays catalysts (KSF, KSF/0, KP10, and K10), having different physicochemical properties, were used as acidic catalysts. The influence of the specific surface area and the acidity of the catalysts on the esterification rate were explored. The best catalytic activities were obtained with KSF catalyst. The optimization of various factors on the reaction was also studied, including catalyst concentration, reaction temperature and molar ratio (polyol / fatty acid). The yield rate reached 94% under the optimum conditions and the recovery rate maintained more than 96% after 5 batches.
[Mh] Termos MeSH primário: Bentonita/química
Ésteres/síntese química
Etilenoglicol/química
Ácidos Graxos/síntese química
Glicerol/química
Ácidos Oleicos/química
Ácidos Esteáricos/química
[Mh] Termos MeSH secundário: Silicatos de Alumínio/química
Catálise
Fenômenos Químicos
Esterificação
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Esters); 0 (Fatty Acids); 0 (Oleic Acids); 0 (Stearic Acids); 1302-78-9 (Bentonite); 1302-87-0 (clay); FC72KVT52F (Ethylene Glycol); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16216


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[PMID]:28376743
[Au] Autor:van Doorn E; Pleguezuelos O; Liu H; Fernandez A; Bannister R; Stoloff G; Oftung F; Norley S; Huckriede A; Frijlink HW; Hak E
[Ad] Endereço:University of Groningen, Unit of PharmacoTherapy- Epidemiology & -Economics, Antonius Deusinglaan, 9713 AV, Groningen, The Netherlands. e.van.doorn@rug.nl.
[Ti] Título:Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial.
[So] Source:BMC Infect Dis;17(1):241, 2017 Apr 04.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population has to be re-vaccinated annually. It is thus important to develop vaccines which induce protective immunity to a broad spectrum of influenza viruses. This trial is designed to evaluate the immunogenicity and safety of FLU-v, a vaccine composed of four synthetic peptides with conserved epitopes from influenza A and B strains expected to elicit both cell mediated immunity (CMI) and humoral immunity providing protection against a broad spectrum of influenza viruses. METHODS: In a single-center, randomized, double-blind and placebo-controlled phase IIb trial, 222 healthy volunteers aged 18-60 years will be randomized (2:2:1:1) to receive two injections of a suspension of 500 µg FLU-v in saline (arm 1), one dose of emulsified 500 µg FLU-v in Montanide ISA-51 and water for injection (WFI) followed by one saline dose (arm 2), two saline doses (arm 3), or one dose of Montanide ISA-51 and WFI emulsion followed by one saline dose (arm 4). All injections will be given subcutaneously. Primary endpoints are safety and FLU-v induced CMI, evaluated by cytokine production by antigen specific T cell populations (flow-cytometry and ELISA). Secondary outcomes are measurements of antibody responses (ELISA and multiplex), whereas exploratory outcomes include clinical efficacy and additional CMI assays (ELISpot) to show cross-reactivity. DISCUSSION: Broadly protective influenza vaccines able to provide protection against multiple strains of influenza are urgently needed. FLU-v is a promising vaccine which has shown to trigger the cell-mediated immune response. The dosages and formulations tested in this current trial are also estimated to induce antibody response. Therefore, both cellular and humoral immune responses will be evaluated. TRIAL REGISTRATION: EudraCT number 2015-001932-38 ; retrospectively registered clinicaltrials.gov NCT02962908 (November 7th 2016).
[Mh] Termos MeSH primário: Imunogenicidade da Vacina
Vacinas contra Influenza/imunologia
Influenza Humana/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticorpos Antivirais/imunologia
Método Duplo-Cego
ELISPOT
Epitopos
Feminino
Seres Humanos
Imunidade Celular
Imunidade Humoral
Vacinas contra Influenza/administração & dosagem
Masculino
Manitol/análogos & derivados
Meia-Idade
Ácidos Oleicos
Orthomyxoviridae/imunologia
Vacinas Sintéticas/imunologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Epitopes); 0 (Influenza Vaccines); 0 (Oleic Acids); 0 (Vaccines, Synthetic); 0 (montanide ISA 51); 3OWL53L36A (Mannitol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2341-9


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[PMID]:28363790
[Au] Autor:Teder T; Boeglin WE; Schneider C; Brash AR
[Ad] Endereço:Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: tarvi.teder@ttu.ee.
[Ti] Título:A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity.
[So] Source:Biochim Biophys Acta;1862(7):706-715, 2017 07.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The genome of the fungal plant pathogen Fusarium graminearum harbors six catalases, one of which has the sequence characteristics of a fatty acid peroxide-metabolizing catalase. We cloned and expressed this hemoprotein (designated as Fg-cat) along with its immediate neighbor, a 13S-lipoxygenase (cf. Brodhun et al., PloS One, e64919, 2013) that we considered might supply a fatty acid hydroperoxide substrate. Indeed, Fg-cat reacts abruptly with the 13S-hydroperoxide of linoleic acid (13S-HPODE) with an initial rate of 700-1300s . By comparison there was no reaction with 9R- or 9S-HPODEs and extremely weak reaction with 13R-HPODE (~0.5% of the rate with 13S-HPODE). Although we considered Fg-cat as a candidate for the allene oxide synthase of the jasmonate pathway in fungi, the main product formed from 13S-HPODE was identified by UV, MS, and NMR as 9-oxo-10E-12,13-cis-epoxy-octadecenoic acid (with no traces of AOS activity). The corresponding analog is formed from the 13S-hydroperoxide of α-linolenic acid along with novel diepoxy-ketones and two C13 aldehyde derivatives, the reaction mechanisms of which are proposed. In a peroxidase assay monitoring the oxidation of ABTS, Fg-cat exhibited robust activity (kcat 550s ) using the 13S-hydroperoxy-C fatty acids as the oxidizing co-substrate. There was no detectable peroxidase activity using the corresponding 9S-hydroperoxides, nor with t-butyl hydroperoxide, and very weak activity with H O or cumene hydroperoxide at micromolar concentrations of Fg-cat. Fg-cat and the associated lipoxygenase gene are present together in fungal genera Fusarium, Metarhizium and Fonsecaea and appear to constitute a partnership for oxidations in fungal metabolism or defense.
[Mh] Termos MeSH primário: Catalase/metabolismo
Ácidos Graxos/metabolismo
Proteínas Fúngicas/metabolismo
Peróxido de Hidrogênio/metabolismo
Lipoxigenase/metabolismo
Peroxidase/metabolismo
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Ciclopentanos/metabolismo
Oxirredutases Intramoleculares/metabolismo
Ácido Linoleico/metabolismo
Peróxidos Lipídicos/metabolismo
Ácidos Oleicos/metabolismo
Oxirredução
Oxilipinas/metabolismo
Estereoisomerismo
terc-Butil Hidroperóxido/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclopentanes); 0 (Fatty Acids); 0 (Fungal Proteins); 0 (Lipid Peroxides); 0 (Oleic Acids); 0 (Oxylipins); 13126-39-1 (13-octadecenoic acid); 6RI5N05OWW (jasmonic acid); 955VYL842B (tert-Butylhydroperoxide); 9KJL21T0QJ (Linoleic Acid); BBX060AN9V (Hydrogen Peroxide); EC 1.11.1.6 (Catalase); EC 1.11.1.7 (Peroxidase); EC 1.13.11.- (13-lipoxygenase); EC 1.13.11.12 (Lipoxygenase); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.99.6 (hydroperoxide isomerase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


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[PMID]:28346411
[Au] Autor:Lynes MD; Leiria LO; Lundh M; Bartelt A; Shamsi F; Huang TL; Takahashi H; Hirshman MF; Schlein C; Lee A; Baer LA; May FJ; Gao F; Narain NR; Chen EY; Kiebish MA; Cypess AM; Blüher M; Goodyear LJ; Hotamisligil GS; Stanford KI; Tseng YH
[Ad] Endereço:Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.
[So] Source:Nat Med;23(5):631-637, 2017 May.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and hyperlipidemia. Cold exposure can enhance energy expenditure by activating BAT, and it has been shown to improve nutrient metabolism. These therapies, however, are time consuming and uncomfortable, demonstrating the need for pharmacological interventions. Recently, lipids have been identified that are released from tissues and act locally or systemically to promote insulin sensitivity and glucose tolerance; as a class, these lipids are referred to as 'lipokines'. Because BAT is a specialized metabolic tissue that takes up and burns lipids and is linked to systemic metabolic homeostasis, we hypothesized that there might be thermogenic lipokines that activate BAT in response to cold. Here we show that the lipid 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a stimulator of BAT activity, and that its levels are negatively correlated with body-mass index and insulin sensitivity. Using a global lipidomic analysis, we found that 12,13-diHOME was increased in the circulation of humans and mice exposed to cold. Furthermore, we found that the enzymes that produce 12,13-diHOME were uniquely induced in BAT by cold stimulation. The injection of 12,13-diHOME acutely activated BAT fuel uptake and enhanced cold tolerance, which resulted in decreased levels of serum triglycerides. Mechanistically, 12,13-diHOME increased fatty acid (FA) uptake into brown adipocytes by promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. These data suggest that 12,13-diHOME, or a functional analog, could be developed as a treatment for metabolic disorders.
[Mh] Termos MeSH primário: Tecido Adiposo Marrom/metabolismo
Temperatura Baixa
Ácidos Graxos/metabolismo
Resistência à Insulina
Obesidade/metabolismo
Ácidos Oleicos/metabolismo
Termogênese
[Mh] Termos MeSH secundário: Tecido Adiposo Marrom/efeitos dos fármacos
Animais
Transporte Biológico/efeitos dos fármacos
Antígenos CD36/efeitos dos fármacos
Antígenos CD36/metabolismo
Membrana Celular/efeitos dos fármacos
Membrana Celular/metabolismo
Metabolismo Energético/efeitos dos fármacos
Proteínas de Transporte de Ácido Graxo/efeitos dos fármacos
Proteínas de Transporte de Ácido Graxo/metabolismo
Feminino
Fluordesoxiglucose F18
Seres Humanos
Masculino
Camundongos
Ácidos Oleicos/biossíntese
Ácidos Oleicos/farmacologia
Sobrepeso/metabolismo
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
RNA Mensageiro/metabolismo
Compostos Radiofarmacêuticos
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (12,13-dihydroxyoctadecenoic acid); 0 (CD36 Antigens); 0 (Fatty Acid Transport Proteins); 0 (Fatty Acids); 0 (Oleic Acids); 0 (RNA, Messenger); 0 (Radiopharmaceuticals); 0 (Slc27a1 protein, mouse); 0 (Triglycerides); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4297



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