Base de dados : MEDLINE
Pesquisa : D10.251.882.800 [Categoria DeCS]
Referências encontradas : 601 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 61 ir para página                         

  1 / 601 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28796777
[Au] Autor:Mouzouvi CRA; Umerska A; Bigot AK; Saulnier P
[Ad] Endereço:'Micro et Nanomédecines biomimétiques-MINT', INSERM U1066 Université d'Angers, CNRS 6021, Université Bretagne Loire, Angers, France.
[Ti] Título:Surface active properties of lipid nanocapsules.
[So] Source:PLoS One;12(8):e0179211, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lipid nanocapsules (LNCs) are biomimetic nanocarriers used for the encapsulation of a broad variety of active ingredients. Similar to surface active compounds, LNCs contain both hydrophilic and hydrophobic parts in their structure. Moreover, the components of LNCs, macrogol 15 hydroxystearate (MHS) and lecithin, are known for their surface active properties. Therefore, the aim of this paper was to investigate the capability of the LNCs to decrease surface tension using two techniques: drop tensiometry and the Wilhelmy plate method. LNCs with diameters ranging from 30 to 100 nm were successfully obtained using a phase inversion technique. The LNCs' properties, such as size and zeta potential, depend on the composition. LNCs exhibit a lower limiting surface tension compared to MHS (34.8-35.0 mN/m and 37.7-38.8 mN/m, respectively), as confirmed by both drop tensiometry and the Wilhelmy plate method. LNCs have exhibited a saturated interfacial concentration (SIC) that was 10-fold higher than the critical micellar concentration (CMC) of MHS or the SIC of binary and ternary mixtures of LNC ingredients. The SIC of the LNC formulations depended on the mass mixing ratio of the MHS/triglycerides but not on the presence of lecithin. The CMC/SIC values measured by the Wilhelmy plate method were higher than those obtained using drop tensiometry because of the longer duration of the tensiometry measurement. In conclusion, the surfactant-like properties of the LNCs offer new possibilities for medical and pharmaceutical applications.
[Mh] Termos MeSH primário: Lipídeos/química
Nanocápsulas/química
[Mh] Termos MeSH secundário: Lecitinas/química
Micelas
Polietilenoglicóis/química
Feijão de Soja/química
Estearatos/química
Propriedades de Superfície
Tensão Superficial
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lecithins); 0 (Lipids); 0 (Micelles); 0 (Nanocapsules); 0 (Stearates); 30IQX730WE (Polyethylene Glycols)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179211


  2 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28415468
[Au] Autor:Al Salloum H; Saunier J; Dazzi A; Vigneron J; Etcheberry A; Marlière C; Aymes-Chodur C; Herry JM; Bernard M; Jubeli E; Yagoubi N
[Ad] Endereço:IFR 141, EA 401, UFR de Pharmacie, Univ. Paris Sud - Université Paris-Saclay, 92290 Chatenay Malabry, France.
[Ti] Título:Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:317-334, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.
[Mh] Termos MeSH primário: Preservação de Sangue/instrumentação
Cloreto de Polivinila/química
[Mh] Termos MeSH secundário: Preservação de Sangue/métodos
Seres Humanos
Lubrificantes/química
Estearatos/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lubricants); 0 (Stearates); 9002-86-2 (Polyvinyl Chloride)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  3 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28242460
[Au] Autor:McDonough K; Itrich N; Casteel K; Menzies J; Williams T; Krivos K; Price J
[Ad] Endereço:The Procter and Gamble Company, Mason Business Center, Mason, OH 45040, USA. Electronic address: mcdonough.k@pg.com.
[Ti] Título:Assessing the biodegradability of microparticles disposed down the drain.
[So] Source:Chemosphere;175:452-458, 2017 May.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Microparticles made from naturally occurring materials or biodegradable plastics such as poly(3-hydroxy butyrate)-co-(3-hydroxy valerate), PHBV, are being evaluated as alternatives to microplastics in personal care product applications but limited data is available on their ultimate biodegradability (mineralization) in down the drain environmental compartments. An OECD 301B Ready Biodegradation Test was used to quantify ultimate biodegradability of microparticles made of PHBV foam, jojoba wax, beeswax, rice bran wax, stearyl stearate, blueberry seeds and walnut shells. PHBV polymer was ready biodegradable reaching 65.4 ± 4.1% evolved CO in 5 d and 90.5 ± 3.1% evolved CO in 80 d. PHBV foam microparticles (125-500 µm) were mineralized extensively with >66% CO evolution in 28 d and >82% CO evolution in 80 d. PHBV foam microparticles were mineralized at a similar rate and extent as microparticles made of jojoba wax, beeswax, rice bran wax, and stearyl stearate which reached 84.8  ± 4.8, 84.9  ± 2.2, 82.7  ± 4.7, and 86.4 ± 3.2% CO evolution respectively in 80 d. Blueberry seeds and walnut shells mineralized more slowly only reaching 39.3  ± 6.9 and 5.1 ± 2.8% CO evolution in 80 d respectively.
[Mh] Termos MeSH primário: Modelos Teóricos
Plásticos/análise
Poliésteres/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Mirtilos Azuis (Planta)/química
Plásticos/química
Poliésteres/química
Sementes/química
Esgotos/microbiologia
Estearatos/química
Águas Residuais/microbiologia
Poluentes Químicos da Água/química
Ceras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plastics); 0 (Polyesters); 0 (Sewage); 0 (Stearates); 0 (Waste Water); 0 (Water Pollutants, Chemical); 0 (Waxes); 0 (poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)); 5WX2EGD0DK (stearyl stearate); 724GKU717M (jojoba wax)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE


  4 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28125209
[Au] Autor:Kascholke C; Loth T; Kohn-Polster C; Möller S; Bellstedt P; Schulz-Siegmund M; Schnabelrauch M; Hacker MC
[Ad] Endereço:Institute of Pharmacy, Pharmaceutical Technology, Leipzig University , Eilenburger Straße 15 a, 04317 Leipzig, Germany.
[Ti] Título:Dual-Functional Hydrazide-Reactive and Anhydride-Containing Oligomeric Hydrogel Building Blocks.
[So] Source:Biomacromolecules;18(3):683-694, 2017 Mar 13.
[Is] ISSN:1526-4602
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biomimetic hydrogels are advanced biomaterials that have been developed following different synthetic routes. Covalent postfabrication functionalization is a promising strategy to achieve efficient matrix modification decoupled of general material properties. To this end, dual-functional macromers were synthesized by free radical polymerization of maleic anhydride with diacetone acrylamide (N-(1,1-dimethyl-3-oxobutyl)acrylamide) and pentaerythritol diacrylate monostearate. Amphiphilic oligomers (M < 7.5 kDa) with anhydride contents of 7-20% offered cross-linking reactivity to yield rigid hydrogels with gelatinous peptides (E = 4-13 kPa) and good cell adhesion properties. Mildly reactive methyl ketones as second functionality remained intact during hydrogel formation and potential of covalent matrix modification was shown using hydrazide and hydrazine model compounds. Successful secondary dihydrazide cross-linking was demonstrated by an increase of hydrogel stiffness (>40%). Efficient hydrazide/hydrazine immobilization depending on solution pH, hydrogel ketone content as well as ligand concentration for bioconjugation was shown and reversibility of hydrazone formation was indicated by physiologically relevant hydrazide release over 7 days. Proof-of-concept experiments with hydrazido-functionalized hyaluronan demonstrated potential for covalent aECM immobilization. The presented dual-functional macromers have perspective as reactive hydrogel building blocks for various biomedical applications.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Hidrogéis/química
Anidridos Maleicos/química
[Mh] Termos MeSH secundário: Acrilamidas/química
Acrilatos/química
Adipatos/química
Adesão Celular
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Gelatina/química
Seres Humanos
Ácido Hialurônico/química
Concentração de Íons de Hidrogênio
Cetonas/química
Polietilenoglicóis/química
Polimerização
Estearatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylamides); 0 (Acrylates); 0 (Adipates); 0 (Biocompatible Materials); 0 (Hydrogels); 0 (Ketones); 0 (Maleic Anhydrides); 0 (N-(1,1-dimethyl-3-oxobutyl)acrylamide); 0 (Stearates); 0 (pentaerythritol diacrylate monostearate); 30IQX730WE (Polyethylene Glycols); 9000-70-8 (Gelatin); 9004-61-9 (Hyaluronic Acid); VK98I9YW5M (adipic dihydrazide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biomac.6b01355


  5 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27914782
[Au] Autor:Ray S; Kalia VC
[Ad] Endereço:Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi 110007, India; Academy of Scientific & Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi 110001, India. Electronic address: subhasreeray141@gmail.com.
[Ti] Título:Co-metabolism of substrates by Bacillus thuringiensis regulates polyhydroxyalkanoate co-polymer composition.
[So] Source:Bioresour Technol;224:743-747, 2017 Jan.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polyhydroxyalkanoate (PHA) production by Bacillus thuringiensis EGU45 was studied by co-metabolism of crude glycerol (CG) (1%, v/v), glucose (0.05-0.5%, w/v) and propionic acid (0.05-0.5%, v/v) under batch (shake flask) culture conditions. Glycerol+PA combination resulted in 15-100mg/L PHA co-polymers with a HV content of 33-81mol%. The addition of NH Cl (0.5%, w/v) to CG+PA enhanced PHA production by 1.55-fold, with a HV content of 58-70mol%. The time period of incubation of PA to the feed: CG+glucose was optimized to be 3h after initiation of fermentation. The PHA contents were found to be stable at 1900-2050mg/L up scaling from 0.4 to 2.0L feed material. Biochemical characterization through GC-MS of PHA co-polymer revealed the presence of 3-hydroxydecanoate (3-HDD), 3-hydroxyoctadecanoate (3HOD), 3-hydroxyhexadecanoate (3HHD).
[Mh] Termos MeSH primário: Bacillus thuringiensis/metabolismo
Poli-Hidroxialcanoatos/biossíntese
Poli-Hidroxialcanoatos/química
[Mh] Termos MeSH secundário: Meios de Cultura/química
Ácidos Decanoicos/análise
Fermentação
Glicerol/metabolismo
Microbiologia Industrial/métodos
Poliésteres/metabolismo
Poli-Hidroxialcanoatos/metabolismo
Estearatos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (Decanoic Acids); 0 (Polyesters); 0 (Polyhydroxyalkanoates); 0 (Stearates); 17773-30-7 (3-hydroxyoctadecanoate); IGH24U4AMF (myrmicacin); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


  6 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27696467
[Au] Autor:Oppolzer D; Barroso M; Passarinha L; Gallardo E
[Ad] Endereço:Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Covilhã, Portugal.
[Ti] Título:Determination of ethyl glucuronide and fatty acid ethyl esters in hair samples.
[So] Source:Biomed Chromatogr;31(4), 2017 Apr.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hair testing for alcohol biomarkers is an important tool for monitoring alcohol consumption. We propose two methods for assessing alcohol exposure through combined analysis of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) species (ethyl myristate, palmitate, stearate and oleate) in hair (30 mg). EtG was analysed by liquid chromatography-tandem mass spectrometry, while FAEEs were analysed by gas chromatography-tandem mass spectrometry using electron impact ionization. Both methods were validated according to internationally accepted guidelines. Linearity was proven between 3 and 500 pg/mg for EtG and 30-5000 pg/mg for FAEEs, and the limits of quantification were 3 pg/mg for EtG and 30 pg/mg for each of the four FAEEs. Precision and accuracy were considered adequate, processed EtG samples were found to be stable for up to 96 h left in the injector and processed FAEEs samples for up to 24 h. Matrix effects were not significant. Both methods were applied to the analysis of 15 authentic samples, using the cut-off values proposed by the Society of Hair Testing for interpretation. The results agreed well with the self-reported alcohol consumption in most cases, and demonstrated the suitability of the methods to be applied in routine analysis of alcohol biomarkers, allowing monitoring consumption using low sample amounts.
[Mh] Termos MeSH primário: Ésteres/análise
Ácidos Graxos/análise
Glucuronatos/análise
Cabelo/química
[Mh] Termos MeSH secundário: Adulto
Consumo de Bebidas Alcoólicas/metabolismo
Biomarcadores/análise
Pré-Escolar
Ácidos Graxos/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Seres Humanos
Limite de Detecção
Miristatos/análise
Ácidos Oleicos/análise
Ácidos Palmíticos/análise
Reprodutibilidade dos Testes
Extração em Fase Sólida
Estearatos/análise
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Esters); 0 (Fatty Acids); 0 (Glucuronates); 0 (Myristates); 0 (Oleic Acids); 0 (Palmitic Acids); 0 (Stearates); 17685-04-0 (ethyl glucuronide); 6995S49749 (ethyl myristate); C64RTC734W (ethyl stearate); IRD3M534ZM (ethyl palmitate); Z2Z439864Y (ethyl oleate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3858


  7 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27507503
[Au] Autor:Sonwai S; Podchong P; Rousseau D
[Ad] Endereço:Department of Food Technology, Faculty of Engineering and Industrial Technology, Silpakorn University, Thailand. Electronic address: ssonwai@gmail.com.
[Ti] Título:Crystallization kinetics of cocoa butter in the presence of sorbitan esters.
[So] Source:Food Chem;214:497-506, 2017 Jan 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cocoa butter crystallization in the presence of sorbitan mono- and triesters or canola oil was investigated. Solid-state surfactant esters accelerated early-stage cocoa butter solidification while suppressing later growth. Sorbitan tristearate showed the strongest effect, followed by sorbitan monostearate and sorbitan monopalmitate. Liquid-state surfactants suppressed cocoa butter crystallization at all time points, with sorbitan trioleate showing a stronger effect than sorbitan monooleate, which behaved in a similar fashion to canola oil. Via DSC, the palmitic and stearic-based surfactants only associated with cocoa butter's high-melting fraction, with the oleic acid-based surfactants and canola oil showing little influence. All sorbitan esters had little effect on polymorphism, whereas canola oil accelerated the form II-to-III-to-IV transition. The palmitic and stearic-based surfactants greatly reduced cocoa butter crystal size whereas the oleic acid-based surfactants and canola showed no notable effect. Overall, sorbitan esters impacted cocoa butter crystallization kinetics, though this depended on surfactant structure and concentration.
[Mh] Termos MeSH primário: Gorduras na Dieta/análise
[Mh] Termos MeSH secundário: Cristalização
Ésteres/química
Hexoses/química
Cinética
Estearatos/química
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Esters); 0 (Hexoses); 0 (Stearates); 0 (Surface-Active Agents); 06XEA2VD56 (sorbitan monooleate); 512OYT1CRR (cocoa butter); 6LUM696811 (sorbitan tristearate); 77K6Z421KU (sorbitan monopalmitate); NVZ4I0H58X (sorbitan monostearate); QE6F49RPJ1 (sorbitan trioleate)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE


  8 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27554171
[Au] Autor:Wang FC; Marangoni AG
[Ad] Endereço:Department of Food Science, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada. Electronic address: fwang03@uoguelph.ca.
[Ti] Título:Advances in the application of food emulsifier α-gel phases: Saturated monoglycerides, polyglycerol fatty acid esters, and their derivatives.
[So] Source:J Colloid Interface Sci;483:394-403, 2016 Dec 01.
[Is] ISSN:1095-7103
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emulsifiers form complex structures in colloidal systems. One of these structures, the α-gel phase, has drawn much research interest. α-gel phases are formed by emulsifiers that are stable in the α-crystalline structure in the presence of water. The α-gel phase has shown superior functionality in a variety of applications because it has a water-rich lamellar structure. Even though studies on emulsifier α-gel phases emerged over half a century ago, there is still a knowledge gap on fundamental properties of α-gel phases formed by a variety of emulsifiers. This article summarizes recent studies on the physical and chemical properties of α-gel phases formed by several food emulsifiers, specifically saturated monoglycerides, polyglycerol monoester and diesters of fatty acid, and sodium stearoyl lactylate. Recent research has advanced the understanding of factors affecting the stability and foamability of the α-gel phases. Current and potential applications of α-gel phases in baked food products and in personal care products are also reviewed here.
[Mh] Termos MeSH primário: Emulsificantes/química
Ácidos Graxos/química
Glicerol/química
Monoglicerídeos/química
Polímeros/química
Estearatos/química
Água/química
[Mh] Termos MeSH secundário: Glicemia/metabolismo
Culinária
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/metabolismo
Ésteres
Ácidos Graxos/metabolismo
Tecnologia de Alimentos
Géis
Glicerol/metabolismo
Seres Humanos
Insulina/sangue
Monoglicerídeos/metabolismo
Transição de Fase
Polímeros/metabolismo
Estearatos/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Dietary Fats); 0 (Emulsifying Agents); 0 (Esters); 0 (Fatty Acids); 0 (Gels); 0 (Insulin); 0 (Monoglycerides); 0 (Polymers); 0 (Stearates); 059QF0KO0R (Water); 25618-55-7 (polyglycerol); 5793-94-2 (stearoyl-2-lactylic acid); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


  9 / 601 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27542728
[Au] Autor:Nie H; Xu W; Ren J; Taylor LS; Marsac PJ; John CT; Byrn SR
[Ad] Endereço:Department of Industrial and Physical Pharmacy, Purdue University , 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
[Ti] Título:Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations.
[So] Source:Mol Pharm;13(10):3541-3552, 2016 Oct 03.
[Is] ISSN:1543-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Excipient-induced salt disproportionation (conversion from salt form to free form) in the solid state during storage or manufacturing is a severe formulation issue that can negatively influence product performance. However, the role of excipient properties on salt disproportionation and mechanisms of proton transfer between salt and excipients are still unclear. Moreover, knowledge about the formation of disproportionation products and the consequent impact of these reactions products on the disproportionation process is still inadequate. In the present study, three commonly used lubricants (sodium stearate, calcium stearate, and magnesium stearate) were mixed with a hydrochloride salt as binary mixtures to examine their different capabilities for inducing salt disproportionation at a stressed storage condition (40 °C/65% RH). The overall objective of this research is to explore factors influencing the kinetics and extent of disproportionation including surface area, alkalinity, hygroscopicity, formation of new species, etc. In addition, we also aim to clarify the reaction mechanism and proton transfer between the model salt and stearates to provide insight into the in situ formed reaction products. We found that the properties of stearates significantly affect the disproportionation process in the initial stage of storage, while properties of the reaction products negatively affect the hygroscopicity of the powder mixture promoting disproportionation during longer-term storage. In addition, lubrication difference among three stearates was evaluated by performing compaction studies. The findings of this study provide an improved understanding of the proton transfer mechanism between the ionized form of an active pharmaceutical ingredient and excipients in solid dosage forms. It also provides pragmatic information for formulation scientists to select appropriate lubricants and other excipients, and to design robust formulations.
[Mh] Termos MeSH primário: Composição de Medicamentos/métodos
Estearatos/química
[Mh] Termos MeSH secundário: Estabilidade de Medicamentos
Excipientes/química
Sais/química
Solubilidade
Ácidos Esteáricos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Salts); 0 (Stearates); 0 (Stearic Acids); 4ELV7Z65AP (stearic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160821
[St] Status:MEDLINE


  10 / 601 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:27312848
[Au] Autor:He L; Weber KJ; Diwan A; Schilling JD
[Ad] Endereço:Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri, USA.
[Ti] Título:Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism.
[So] Source:J Leukoc Biol;100(5):1113-1124, 2016 Nov.
[Is] ISSN:1938-3673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Macrophage dysfunction in obesity and diabetes is associated with persistent inflammation and poor wound healing responses. Relevant to these phenotypes, we have previously shown that macrophage activation in a high-fat environment results in cell death via a mechanism that involves lysosome damage. While searching for signaling pathways that were required for this response, we discovered that mTOR inhibitors, torin and rapamycin, were protective against lipotoxic cell death in primary peritoneal macrophages. The protective effect of mTOR inhibition was also confirmed by using genetic loss-of-function approaches. Given the importance of mTOR in regulation of autophagy we hypothesized that this pathway would be important in protection from cell death. We first demonstrated that autophagy was disrupted in response to palmitate and LPS as a consequence of impaired lysosome function. Conversely, the mTOR inhibitor, torin, increased macrophage autophagy and protected against lysosome damage; however, the beneficial effects of torin persisted in autophagy-deficient cells. Inhibition of mTOR also triggered nuclear localization of TFEB, a transcription factor that regulates lysosome biogenesis and function, but the rescue phenotype did not require the presence of TFEB. Instead, we demonstrated that mTOR inhibition reduces mitochondrial oxidative metabolism and attenuates the negative effects of palmitate on LPS-induced mitochondrial respiration. These results suggest that inhibition of mTOR is protective against lipotoxicity via an autophagy-independent mechanism that involves relieving mitochondrial substrate overload. On the basis of these findings, we suggest that therapies to reduce macrophage mTOR activation may protect against dysfunctional inflammation in states of overnutrition, such as diabetes.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/farmacologia
Macrófagos Peritoneais/efeitos dos fármacos
Palmitatos/toxicidade
Sirolimo/farmacologia
Estearatos/toxicidade
Serina-Treonina Quinases TOR/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Autofagia/efeitos dos fármacos
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/fisiologia
Morte Celular/efeitos dos fármacos
Morte Celular/fisiologia
Núcleo Celular/metabolismo
Avaliação Pré-Clínica de Medicamentos
Lipopolissacarídeos/toxicidade
Lisossomos/efeitos dos fármacos
Macrófagos Peritoneais/citologia
Macrófagos Peritoneais/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Mitocôndrias/metabolismo
Palmitatos/farmacologia
Interferência de RNA
RNA Interferente Pequeno/genética
Organismos Livres de Patógenos Específicos
Estearatos/farmacologia
Serina-Treonina Quinases TOR/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Blood Proteins); 0 (Lipopolysaccharides); 0 (Palmitates); 0 (RNA, Small Interfering); 0 (Stearates); 0 (Tcfeb protein, mouse); 0 (torin); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.1 (mTOR protein, mouse); W36ZG6FT64 (Sirolimus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE



página 1 de 61 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde