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[PMID]:28456646
[Au] Autor:Ng WY; Migotto A; Ferreira TS; Lopes LB
[Ad] Endereço:Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Albany, NY, USA.
[Ti] Título:Monoolein-alginate beads as a platform to promote adenosine cutaneous localization and wound healing.
[So] Source:Int J Biol Macromol;102:1104-1111, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Alginate beads containing the polar lipid monoolein were developed as a strategy to manage wet wounds by providing improved uptake of excess exudate while releasing adenosine locally for promotion of healing. To obtain monoolein-containing beads, the lipid was mixed with almond oil (2:1w/w), and emulsified within the alginate aqueous dispersion, followed by ionotropic gelation in CaCl solution. Compared to alginate-only, monoolein-alginate systems were 1.44-fold larger, their swelling ability was 1.40-fold higher and adenosine cumulative release was approximately 1.30-fold lower (at 24h). Monoolein-alginate beads were considered safe for topical application as demonstrated by the absence of changes on the viability of reconstructed skin equivalents compared to PBS. Smaller amounts of adenosine were delivered by the beads into and across damaged porcine skin (created by an incisional wound) compared to the drug aqueous solution, and cutaneous localization was favored. More specifically, the beads increased the viable skin layer/receptor phase delivery ratio by approximately 4-fold at 12h post-application. Considering the wide range of adenosine physiological effects and the importance of skin localization for its use in wound healing, these results demonstrate the potential of monoolein-containing beads for localized drug delivery and management of wet wounds.
[Mh] Termos MeSH primário: Adenosina/metabolismo
Alginatos/química
Portadores de Fármacos/química
Glicerídeos/química
Microesferas
Pele/metabolismo
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adenosina/química
Adenosina/farmacologia
Animais
Liberação Controlada de Fármacos
Ácido Glucurônico/química
Ácidos Hexurônicos/química
Permeabilidade
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Drug Carriers); 0 (Glycerides); 0 (Hexuronic Acids); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); C4YAD5F5G6 (monoolein); K72T3FS567 (Adenosine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29260544
[Au] Autor:Tiong SH; Saparin N; Teh HF; Ng TLM; Md Zain MZB; Neoh BK; Md Noor A; Tan CP; Lai OM; Appleton DR
[Ad] Endereço:Sime Darby Technology Centre Sdn. Bhd. , 1st Floor, Block B, UPM-MTDC Technology Centre III, Lebuh Silikon, 43400 Serdang, Selangor, Malaysia.
[Ti] Título:Natural Organochlorines as Precursors of 3-Monochloropropanediol Esters in Vegetable Oils.
[So] Source:J Agric Food Chem;66(4):999-1007, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During high-temperature refining of vegetable oils, 3-monochloropropanediol (3-MCPD) esters, possible carcinogens, are formed from acylglycerol in the presence of a chlorine source. To investigate organochlorine compounds in vegetable oils as possible precursors for 3-MCPD esters, we tested crude palm, soybean, rapeseed, sunflower, corn, coconut, and olive oils for the presence of organochlorine compounds. Having found them in all vegetable oils tested, we focused subsequent study on oil palm products. Analysis of the chlorine isotope mass pattern exhibited in high-resolution mass spectrometry enabled organochlorine compound identification in crude palm oils as constituents of wax esters, fatty acid, diacylglycerols, and sphingolipids, which are produced endogenously in oil palm mesocarp throughout ripening. Analysis of thermal decomposition and changes during refining suggested that these naturally present organochlorine compounds in palm oils and perhaps in other vegetable oils are precursors of 3-MCPD esters. Enrichment and dose-response showed a linear relationship to 3-MCPD ester formation and indicated that the sphingolipid-based organochlorine compounds are the most active precursors of 3-MCPD esters.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados/química
Óleos Vegetais/química
alfa-Cloridrina/química
[Mh] Termos MeSH secundário: Carcinógenos
Cloro/química
Ésteres/química
Contaminação de Alimentos
Manipulação de Alimentos
Glicerídeos/química
Óleo de Palmeira/química
alfa-Cloridrina/análise
alfa-Cloridrina/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Esters); 0 (Glycerides); 0 (Hydrocarbons, Chlorinated); 0 (Plant Oils); 4R7X1O2820 (Chlorine); 5QUO05548Z (Palm Oil); 96-24-2 (alpha-Chlorohydrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04995


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[PMID]:29179781
[Au] Autor:Pei R; DiMarco DM; Putt KK; Martin DA; Gu Q; Chitchumroonchokchai C; White HM; Scarlett CO; Bruno RS; Bolling BW
[Ad] Endereço:1Department of Nutritional Sciences,University of Connecticut,3624 Horsebarn Road Extension,Unit 4017,Storrs,CT 06269,USA.
[Ti] Título:Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial.
[So] Source:Br J Nutr;118(12):1043-1051, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The anti-inflammatory mechanisms of low-fat dairy product consumption are largely unknown. The objective of this study was to determine whether low-fat yogurt reduces biomarkers of chronic inflammation and endotoxin exposure in women. Premenopausal women (BMI 18·5-27 and 30-40 kg/m2) were randomised to consume 339 g of low-fat yogurt (yogurt non-obese (YN); yogurt obese (YO)) or 324 g of soya pudding (control non-obese; control obese (CO)) daily for 9 weeks (n 30/group). Fasting blood samples were analysed for IL-6, TNF-α/soluble TNF II (sTNF-RII), high-sensitivity C-reactive protein, 2-arachidonoyl glycerol, anandamide, monocyte gene expression, soluble CD14 (sCD14), lipopolysaccharide (LPS), LPS binding protein (LBP), IgM endotoxin-core antibody (IgM EndoCAb), and zonulin. BMI, waist circumference and blood pressure were also determined. After 9-week yogurt consumption, YO and YN had decreased TNF-α/sTNFR-RII. Yogurt consumption increased plasma IgM EndoCAb regardless of obesity status. sCD14 was not affected by diet, but LBP/sCD14 was lowered by yogurt consumption in both YN and YO. Yogurt intervention increased plasma 2-arachidonoylglycerol in YO but not YN. YO peripheral blood mononuclear cells expression of NF-κB inhibitor α and transforming growth factor ß1 increased relative to CO at 9 weeks. Other biomarkers were unchanged by diet. CO and YO gained approximately 0·9 kg in body weight. YO had 3·6 % lower diastolic blood pressure at week 3. Low-fat yogurt for 9 weeks reduced biomarkers of chronic inflammation and endotoxin exposure in premenopausal women compared with a non-dairy control food. This trial was registered as NCT01686204.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Dieta
Endotoxinas/toxicidade
Inflamação/sangue
Inflamação/dietoterapia
Iogurte/análise
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda
Adulto
Antropometria
Ácidos Araquidônicos/sangue
Proteína C-Reativa/metabolismo
Proteínas de Transporte/sangue
Doença Crônica
Citocinas/sangue
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/análise
Endocanabinoides/sangue
Endotoxemia/sangue
Endotoxemia/dietoterapia
Feminino
Glicerídeos/sangue
Seres Humanos
Imunoglobulina M/sangue
Leucócitos Mononucleares/metabolismo
Glicoproteínas de Membrana/sangue
Meia-Idade
NF-kappa B/metabolismo
Obesidade/metabolismo
Alcamidas Poli-Insaturadas/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Arachidonic Acids); 0 (Biomarkers); 0 (Carrier Proteins); 0 (Cytokines); 0 (Dietary Fats); 0 (Endocannabinoids); 0 (Endotoxins); 0 (Glycerides); 0 (Immunoglobulin M); 0 (Membrane Glycoproteins); 0 (NF-kappa B); 0 (Polyunsaturated Alkamides); 0 (lipopolysaccharide-binding protein); 8D239QDW64 (glyceryl 2-arachidonate); 9007-41-4 (C-Reactive Protein); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003038


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[PMID]:29262505
[Au] Autor:Wu WJ; Wang Q; Zhang W; Li L
[Ad] Endereço:Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guangxi Medical University, and Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Ministry of Education, Nanning 530021, China (Currently Address: Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guangzho
[Ti] Título:[Discrimination and clinical value of plasma metabolomic profiles in multidrug resistant epithelial ovarian cancer].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(12):896-902, 2017 Dec 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the alteration of plasma metabolomic profiles, screen the new serum markers of multidrug resistant epithelial ovarian cancer (EOC), and investigate the mechanism. The serum of 132 cases with cisplatin-resistant EOC, cisplatin-sensitive EOC, benign ovarian cyst and healthy donors were collected. Differentially plasma metabolic profiles were identified by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). The significantly different metabolites of each group were screened by using principal component analysis. Then compounds that played a key role in cisplatin resistance were identified by using nuclear magnetic resonance (NMR). The relationships between these compounds and clinical characteristics and prognosis were analyzed. LC-MS/MS identified 25 800 metabolic compounds. According to the descending dimension algorithm by principal component analysis, six compounds which were the biggest contributor to grouping were identified. The identified results of NMR showed that the serum level of C16 Sphinganine was lower while Dodemorph was higher in the EOC than those of the normal control. Compared to the cisplatin sensitive group, cisplatin resistant group exhibited a specific metabolic trait characterized by upregulation of 1-Monopalmitin, Ricinoleic acid methyl ester, Polyoxyethylene (600) mono-ricinoleate/Glycidyl stearate and downregulation of Calycanthidine. The four components were all associated with fatty acid metabolism, and the combinational diagnostic sensitivity of these biomarkers for cisplatin-resistance was 86.50% and the specificity was 81.80%, the area of receiver operating characteristic (ROC) curve was 0.93. The metabolic signatures of normal control, benign ovarian cyst, cisplatin sensitivity and cisplatin resistance can be clearly separated from each other by LC-MS/MS technology.The combinational four biomarkers including Calycanthidine, 1-Monopalmitin, Ricinoleic acid methl ester and Polyoxyethylene (600) mono-ricinoleate/Glycidyl stearate are more sensitive and specific for the diagnosis of cisplatin resistant EOC, and may provide the potentially predict markers of chemotherapeutic response in metabolic level. The fatty acid metabolism may participate in the cisplatin resistant progression of EOC.
[Mh] Termos MeSH primário: Resistência a Múltiplos Medicamentos
Resistência a Medicamentos Antineoplásicos
Metaboloma
Neoplasias Epiteliais e Glandulares/sangue
Neoplasias Epiteliais e Glandulares/tratamento farmacológico
Neoplasias Ovarianas/sangue
Neoplasias Ovarianas/tratamento farmacológico
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Biomarcadores Tumorais/sangue
Cromatografia Líquida
Cisplatino/farmacologia
Feminino
Glicerídeos/metabolismo
Seres Humanos
Espectroscopia de Ressonância Magnética
Metabolômica
Prognóstico
Curva ROC
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers, Tumor); 0 (Glycerides); Q20Q21Q62J (Cisplatin); U9H9OM3S75 (palmitoyl glycerol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.12.004


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[PMID]:29337670
[Au] Autor:Hanif M; Khan HU; Afzal S; Mahmood A; Maheen S; Afzal K; Iqbal N; Andleeb M; Abbas N
[Ad] Endereço:1Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
[Ti] Título:Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology.
[So] Source:Acta Pharm;67(4):441-461, 2017 Dec 20.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug release (Y3). SLMs having a 10-40 µm size range, with good rheological behavior and spherical smooth surfaces, were produced. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry pointed to compatibility between formulation components and the zeta-potential study confirmed better stability due to the presence of negative charge (-20 to -40 mV). The obtained outcomes for Y1 (29-86 %), Y2 (45-83 %) and Y3 (49-86 %) were analyzed by polynomial equations and the suggested quadratic model were validated. Nebivolol release from SLMs at pH 1.2 and 6.8 was significantly (p < 0.05) affected by lipid concentration. The release mechanism followed Higuchi and zero order models, while n > 0.85 value (Korsmeyer- Peppas) suggested slow erosion along with diffusion. The optimized SLMs have the potential to improve nebivolol oral bioavailability.
[Mh] Termos MeSH primário: Preparações de Ação Retardada/química
Composição de Medicamentos/métodos
Glicerídeos/química
Ceras/química
[Mh] Termos MeSH secundário: Calorimetria/métodos
Portadores de Fármacos/química
Nebivolol/farmacocinética
Tamanho da Partícula
Espectroscopia de Infravermelho com Transformada de Fourier
Propriedades de Superfície
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Drug Carriers); 0 (Glycerides); 0 (Waxes); 030Y90569U (Nebivolol); 230OU9XXE4 (glyceryl monostearate); R12CBM0EIZ (carnauba wax)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


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[PMID]:28946274
[Au] Autor:Morales-Medina R; Munio M; Guadix A; Guadix EM; Camacho F
[Ad] Endereço:Department of Chemical Engineering, University of Granada, 18071 Granada, Spain. Electronic address: rocio_morales@ugr.es.
[Ti] Título:A lumped model of the lipase catalyzed hydrolysis of sardine oil to maximize polyunsaturated fatty acids content in acylglycerols.
[So] Source:Food Chem;240:286-294, 2018 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to produce diacylglycerols (DAG) and monoacylglycerols (MAG) with a high content of polyunsaturated fatty acids (PUFA). Rhizomucor miehei lipase mediated-hydrolysis of sardine oil was conducted at several water activities. The system was mechanistically modeled to predict the time evolution of the concentration of triacylglycerols, DAG, MAG and free fatty acids (FFA) and the concentration of saturated, mono- and polyunsaturated fatty acids. The release of the first fatty acid from the triacylglycerol was independent on the unsaturation degree. Contrary, the hydrolysis of the second one was highly affected by the degree of unsaturation, PUFA being the fatty acids that showed the highest resistance to hydrolysis. MAG percentage was maximum (7mol%) at lower water activities, while DAG content was favored at higher water activities (35mol%), achieving a 2-fold concentration of DHA.
[Mh] Termos MeSH primário: Óleos de Peixe/metabolismo
Lipase/metabolismo
[Mh] Termos MeSH secundário: Animais
Ácidos Graxos
Ácidos Graxos Insaturados
Peixes
Glicerídeos
Hidrólise
Rhizomucor
Triglicerídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Unsaturated); 0 (Fish Oils); 0 (Glycerides); 0 (Triglycerides); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE


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[PMID]:28965424
[Au] Autor:Rinaldi F; Hanieh PN; Longhi C; Carradori S; Secci D; Zengin G; Ammendolia MG; Mattia E; Del Favero E; Marianecci C; Carafa M
[Ad] Endereço:a Fondazione Istituto Italiano di Tecnologia , Center for Life Nano Science@Sapienza , Rome , Italy.
[Ti] Título:Neem oil nanoemulsions: characterisation and antioxidant activity.
[So] Source:J Enzyme Inhib Med Chem;32(1):1265-1273, 2017 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 to 100 nm was obtained by modulating the oil/surfactant ratio. Physicochemical characterisation was carried out evaluating size, ζ-potential, microviscosity, polarity and turbidity of the external shell and morphology, along with stability in simulated cerebrospinal fluid (CSF), activity of Neem oil alone and in NEs, HEp-2 cell interaction and cytotoxicity studies. This study confirms the formation of NEs by Tween 20 and Neem oil at different weight ratios with small and homogenous dimensions. The antioxidant activity of Neem oil alone and in NEs was comparable, whereas its cytotoxicity was strongly reduced when loaded in NEs after interaction with HEp-2 cells.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Glicerídeos/farmacologia
Nanopartículas/química
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/síntese química
Antioxidantes/química
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Emulsões/síntese química
Emulsões/química
Emulsões/farmacologia
Glicerídeos/síntese química
Glicerídeos/química
Seres Humanos
Tamanho da Partícula
Relação Estrutura-Atividade
Terpenos/síntese química
Terpenos/química
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Emulsions); 0 (Glycerides); 0 (Terpenes); 4DKJ9B3K2T (neem oil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1378190


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[PMID]:28938452
[Au] Autor:Forner-Piquer I; Maradonna F; Gioacchini G; Santangeli S; Allarà M; Piscitelli F; Habibi HR; Di Marzo V; Carnevali O
[Ad] Endereço:Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, 60131 Ancona, Italy.
[Ti] Título:Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish.
[So] Source:Endocrinology;158(10):3462-3476, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phthalates, used as plasticizers, have become a ubiquitous contaminant and have been reported for their potential to induce toxicity in living organisms. Among them, di-isononyl phthalate (DiNP) has been recently used to replace di(2-ethylhexyl) phthalate (DEHP). Nowadays, there is evidence that DiNP is an endocrine-disrupting chemical; however, little is known about its effects on the endocannabinoid system (ECS) and lipid metabolism. Hence, the aim of our study was to investigate the effects of DiNP on the ECS in zebrafish liver and brain and on hepatic lipid storage. To do so, adult female zebrafish were exposed to three concentrations (0.42 µg/L, 4.2 µg/L, and 42 µg/L) of DiNP via water for 3 weeks. Afterwards, we investigated transcript levels for genes involved in the ECS of the brain and liver as well as liver histology and image analysis, Fourier-transform infrared spectroscopy imaging, and measurement of endocannabinoid levels. Our results demonstrate that DiNP upregulates orexigenic signals and causes hepatosteatosis together with deregulation of the peripheral ECS and lipid metabolism. A decrease in the levels of ECS components at the central level was observed after exposure to the highest DiNP concentration tested. These findings suggest that replacement of DEHP with DiNP should be considered with caution because of observed adverse DiNP effects on aquatic organisms.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Endocanabinoides/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Ácidos Ftálicos/farmacologia
Plastificantes/farmacologia
[Mh] Termos MeSH secundário: Animais
Ácidos Araquidônicos/metabolismo
Encéfalo/metabolismo
Relação Dose-Resposta a Droga
Disruptores Endócrinos/farmacologia
Fígado Gorduroso/metabolismo
Feminino
Expressão Gênica/efeitos dos fármacos
Glicerídeos/metabolismo
Lipase Lipoproteica/efeitos dos fármacos
Lipase Lipoproteica/genética
Lipase Lipoproteica/metabolismo
Fosfolipase D/efeitos dos fármacos
Fosfolipase D/genética
Fosfolipase D/metabolismo
Alcamidas Poli-Insaturadas/metabolismo
Receptor CB1 de Canabinoide/efeitos dos fármacos
Receptor CB1 de Canabinoide/genética
Receptor CB1 de Canabinoide/metabolismo
Receptor CB2 de Canabinoide/efeitos dos fármacos
Receptor CB2 de Canabinoide/genética
Receptor CB2 de Canabinoide/metabolismo
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arachidonic Acids); 0 (Endocannabinoids); 0 (Endocrine Disruptors); 0 (Glycerides); 0 (Phthalic Acids); 0 (Plasticizers); 0 (Polyunsaturated Alkamides); 0 (Receptor, Cannabinoid, CB1); 0 (Receptor, Cannabinoid, CB2); 4010KIX4CK (diisononyl phthalate); 8D239QDW64 (glyceryl 2-arachidonate); EC 3.1.1.34 (Lipoprotein Lipase); EC 3.1.4.4 (N-acylphosphatidylethanolamine phospholipase D, mouse); EC 3.1.4.4 (Phospholipase D); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00458


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[PMID]:28888939
[Au] Autor:Takahashi H; Jojiki K
[Ad] Endereço:Biophysics Laboratory, Division of Pure and Applied Science, Graduate School of Science and Technology, Gunma University, 4-2 Aramaki, Maebashi, Gunma 371-8510, Japan. Electronic address: hirotakahashi@gunma-u.ac.jp.
[Ti] Título:Water isotope effect on the lipidic cubic phase: Heavy water-Induced interfacial area reduction of monoolein-Water system.
[So] Source:Chem Phys Lipids;208:52-57, 2017 Nov.
[Is] ISSN:1873-2941
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Heavy water (D O) affects various functions of cells and living things. In order to gain fundamental insight into the molecular mechanism on biological effects of heavy water, D O-effects on fully hydrated monoolein (MO) systems were investigated from the structural viewpoints. At room temperature, the MO fully hydrated by pure light water (H O) forms a bicontinuous cubic (Pn3m) phase, and then, the Pn3m cubic phase transforms into an inverted hexagonal (H ) phase at about 90°C. Temperature-scan X-ray diffraction measurements showed that substitution of D O for H O lowers the Pn3m-to-H phase transition temperature and reduces the lattice constants of both phases. The structural analysis of the Pn3m phase using the diffraction intensity data indicated that D O reduces the surface occupied area of MO at the interface by 12% in comparison with H O. This change is probably due to the difference of the strength of hydrogen bond.
[Mh] Termos MeSH primário: Óxido de Deutério/química
Glicerídeos/química
[Mh] Termos MeSH secundário: Propriedades de Superfície
Temperatura de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerides); C4YAD5F5G6 (monoolein); J65BV539M3 (Deuterium Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


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[PMID]:28853554
[Au] Autor:Martin GG; Huang H; McIntosh AL; Kier AB; Schroeder F
[Ad] Endereço:Department of Physiology and Pharmacology, Texas A&M University , College Station, Texas 77843-4466, United States.
[Ti] Título:Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant.
[So] Source:Biochemistry;56(38):5147-5159, 2017 Sep 26.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using recombinant human wild-type fatty acid binding protein 1 (WT FABP1 T94T) and a variant (FABP1 T94A) protein, fluorescence binding assays, and circular dichroism, it was shown for the first time that WT FABP1 and the T94A variant each have a single, relatively hydrophobic site for binding fluorescent NBD-labeled analogues of N-arachidonoylethanolamide and 2-arachidonoylglycerol with high affinity. Most native N-acylethanolamides (NAEs) but only one 2-monoacylglycerol [i.e., 2-arachidonoylglycerol (2-AG)] displaced WT FABP1-bound fluorescently labeled endocannabinoids (ECs). While the T94A variant did not differ in affinity for AEA and most other NAEs, it exhibited a modestly higher affinity for OEA, as well as a higher affinity for 2-AG. Binding of AEA and 2-AG altered WT FABP1's secondary structure more extensively than any other previously examined ligand did. The T94A variant without a ligand was more susceptible to temperature-induced unfolding. While the T94A variant was much less sensitive to ligand (i.e., AEA or 2-AG)-induced conformational change, nevertheless binding of AEA and 2-AG significantly stabilized the T94A structure to thermal unfolding. These data provide the first evidence that ECs not only bind to but also alter the secondary structure of the human FABP1, with the latter markedly impacted by the T94A substitution, a variant strongly associated with hepatic accumulation of lipids and non-alcoholic fatty liver disease (NAFLD). Importantly, NAFLD has been associated with elevated hepatic levels of ECs and FABP1.
[Mh] Termos MeSH primário: Endocanabinoides/metabolismo
Proteínas de Ligação a Ácido Graxo/química
Proteínas de Ligação a Ácido Graxo/metabolismo
[Mh] Termos MeSH secundário: Animais
Ácidos Araquidônicos/metabolismo
Sítios de Ligação
Dicroísmo Circular
Endocanabinoides/química
Proteínas de Ligação a Ácido Graxo/genética
Fluorescência
Glicerídeos/metabolismo
Seres Humanos
Alcamidas Poli-Insaturadas/metabolismo
Estrutura Secundária de Proteína
Ratos
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arachidonic Acids); 0 (Endocannabinoids); 0 (FABP1 protein, human); 0 (Fabp1 protein, rat); 0 (Fatty Acid-Binding Proteins); 0 (Glycerides); 0 (Polyunsaturated Alkamides); 8D239QDW64 (glyceryl 2-arachidonate); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00647



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