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[PMID]:27770636
[Au] Autor:Mez J; Chung J; Jun G; Kriegel J; Bourlas AP; Sherva R; Logue MW; Barnes LL; Bennett DA; Buxbaum JD; Byrd GS; Crane PK; Ertekin-Taner N; Evans D; Fallin MD; Foroud T; Goate A; Graff-Radford NR; Hall KS; Kamboh MI; Kukull WA; Larson EB; Manly JJ; Haines JL; Mayeux R; Pericak-Vance MA; Schellenberg GD; Lunetta KL; Farrer LA; Alzheimer's Disease Genetics Consortium
[Ad] Endereço:Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA. Electronic address: jessemez@bu.edu.
[Ti] Título:Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.
[So] Source:Alzheimers Dement;13(2):119-129, 2017 Feb.
[Is] ISSN:1552-5279
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: African Americans' (AAs) late-onset Alzheimer's disease (LOAD) genetic risk profile is incompletely understood. Including clinical covariates in genetic analyses using informed conditioning might improve study power. METHODS: We conducted a genome-wide association study (GWAS) in AAs employing informed conditioning in 1825 LOAD cases and 3784 cognitively normal controls. We derived a posterior liability conditioned on age, sex, diabetes status, current smoking status, educational attainment, and affection status, with parameters informed by external prevalence information. We assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs. RESULTS: Two SNPs at novel loci, rs112404845 (P = 3.8 × 10 ), upstream of COBL, and rs16961023 (P = 4.6 × 10 ), downstream of SLC10A2, obtained genome-wide significant evidence of association with the posterior liability. DISCUSSION: An informed conditioning approach can detect LOAD genetic associations in AAs not identified by traditional GWAS.
[Mh] Termos MeSH primário: Afroamericanos/genética
Doença de Alzheimer/etnologia
Doença de Alzheimer/genética
Loci Gênicos
Proteínas dos Microfilamentos/genética
Transportadores de Ânions Orgânicos Dependentes de Sódio/genética
Polimorfismo de Nucleotídeo Único
Simportadores/genética
[Mh] Termos MeSH secundário: Transportadores de Cassetes de Ligação de ATP/genética
Idoso
Idoso de 80 Anos ou mais
Apolipoproteínas E/genética
Complicações do Diabetes/etnologia
Complicações do Diabetes/genética
Escolaridade
Feminino
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Seres Humanos
Masculino
Prevalência
Fumar/etnologia
Fumar/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABCA7 protein, human); 0 (ATP-Binding Cassette Transporters); 0 (Apolipoproteins E); 0 (Cobl protein, human); 0 (Microfilament Proteins); 0 (Organic Anion Transporters, Sodium-Dependent); 0 (Symporters); 145420-23-1 (sodium-bile acid cotransporter)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29390290
[Au] Autor:Zhang Y; Liu S; Yue W; Shi Z; Guan Y; Li M; Ji Y; Li X
[Ad] Endereço:Department of Neurology, The Second Hospital of Tianjin Medical University,Tianjin, China.
[Ti] Título:Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients.
[So] Source:Medicine (Baltimore);96(50):e8964, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to study the ability of the genotype to predict impairment and disability in hospitalized ischemic stroke (IS) patients after hospital discharge and 6 months after the onset of stroke symptoms.A total of 786 patients with a first IS were enrolled. Apolipoprotein E (ApoE) polymorphism was examined using polymerase chain reaction. Stroke subtype was classified using the Oxfordshire Community Stroke Project classification scheme and the Trial of Org 10172 in Acute Stroke Treatment criteria. Impairment as assessed using the National Institutes of Health Stroke Scale (NIHSS), and disability as measured using the modified Rankin Scale (mRS), were compared against the ApoE genotype.There was no significant association between the type of ApoE allele present and the stroke subtype. On multivariate regression analysis, the apolipoprotein EE4 allele genotype did not predict poor outcome at discharge and or at 6 months after stroke onset. A higher NIHSS score on admission, older age, and higher fasting glucose levels did predict poor outcome at hospital discharge. Higher glucose levels and higher NIHSS scores on admission were independent risk factors predicting poor neurologic status at 6 months after stroke onset.The presence of the apolipoprotein EE4 and apolipoprotein EE2 genotypes, although related to cholesterol and triglyceride levels, do not affect recovery during rehabilitation. A higher NIHSS score on admission and a higher fasting glucose level predict poor neurologic status, both at hospital discharge and 6 months after onset.
[Mh] Termos MeSH primário: Apolipoproteínas E/genética
Isquemia Encefálica/genética
Acidente Vascular Cerebral/genética
[Mh] Termos MeSH secundário: Alelos
Isquemia Encefálica/classificação
Feminino
Genótipo
Seres Humanos
Masculino
Reação em Cadeia da Polimerase
Fatores de Risco
Acidente Vascular Cerebral/classificação
Reabilitação do Acidente Vascular Cerebral
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008964


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[PMID]:28747136
[Au] Autor:Kahya M; Vidoni E; Burns JM; Thompson AN; Meyer K; Siengsukon CF
[Ad] Endereço:1 Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS, USA.
[Ti] Título:The Relationship Between Apolipoprotein ε4 Carrier Status and Sleep Characteristics in Cognitively Normal Older Adults.
[So] Source:J Geriatr Psychiatry Neurol;30(5):273-279, 2017 Sep.
[Is] ISSN:0891-9887
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The apolipoprotein (APOE) ε4 allele, a well-described genetic risk factor for late-onset Alzheimer disease (AD), is associated with sleep disturbances even in cognitively normal older adults, although it is not clear whether this association is independent of sleep apnea. We sought to extend previous studies by examining whether cognitively normal older adults without self-reported sleep apnea who carry the APOE ε4 allele have altered sleep characteristics compared to noncarriers. Data from N = 36 (APOE ε4 carriers [n = 9], noncarriers [n = 27]) cognitively normal older adults (Clinical Dementia Rating [CDR] scale = 0) without self-reported sleep apnea were used for these analyses. Participants wore an actigraph for 7 days to determine sleep characteristics. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were used to assess sleep quality and daytime sleepiness, respectively. The APOE ε4 carriers had a higher number of awakenings compared to the noncarriers ( P = .02). There was no significant difference in the PSQI global score and the ESS; however, the PSQI subcomponent of daily disturbances was significantly higher in APOE ε4 carriers ( P = .03), indicating increased daytime dysfunction is related to disrupted sleep. This study provides evidence that individuals who are cognitively normal and genetically at risk of AD may have disrupted sleep. These findings are consistent with prior studies and suggest that sleep disruption may be present in the presymptomatic stages of AD.
[Mh] Termos MeSH primário: Doença de Alzheimer/genética
Apolipoproteínas E/genética
Cognição/fisiologia
Transtornos do Sono-Vigília/genética
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Transtornos do Sono-Vigília/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ApoE protein, human); 0 (Apolipoproteins E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1177/0891988717720301


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[PMID]:29428127
[Au] Autor:Liao J; Liu X; Gao M; Wang M; Wang Y; Wang F; Huang W; Liu G
[Ad] Endereço:Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China; Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center,
[Ti] Título:Dyslipidemia, steatohepatitis and atherogenesis in lipodystrophic apoE deficient mice with Seipin deletion.
[So] Source:Gene;648:82-88, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:SEIPIN is an integral membrane protein located in the endoplasmic reticulum, regulating adipocytes differentiation and lipolysis. Deficiency of Seipin in mice causes severe general lipodystrophy, accompanied by insulin resistance, postprandial hypertriglyceridemia and steatohepatitis. In atherosclerosis-prone Ldlr null (Ldlr ) mice, lipodystrophy caused by Seipin deletion even led to severe hypercholesteremia and accelerated atherogenesis, when challenged with an atherogenic diet. However, whether the phenotypes observed in Seipin Ldlr mice were a common consequence due to lipodystrophy, rather than genetic background restricted or diet dependent, was unknown. Herein we explored the lipodystrophy-related dyslipidemia, steatohepatitis and atherogenesis in another atherosclerosis-prone murine model, apolipoprotein E null (apoE ) mice. Besides, we also compared phenotypes between sexes in apoE mice with Seipin deletion (Seipin apoE ). We found that compared with apoE controls, Seipin apoE mice also developed severe general lipodystrophy with hyperlipidemia, steatohepatitis and increased atherogenesis. Although the severity of adipose loss in female and male Seipin apoE mice were similar, hyperlipidemia, steatohepatitis and atherosclerosis were less severe in females than in males. Therefore, we demonstrated that lipodystrophy-related metabolic disorders, caused by Seipin deletion, were independent of genetic background and experimental diet, as seen in Ldlr and apoE mice. However, gender factor affected the disease progression, with females more resistant to developing lipodystrophy-related metabolic consequences.
[Mh] Termos MeSH primário: Apolipoproteínas E/genética
Aterosclerose/genética
Dislipidemias/genética
Fígado Gorduroso/genética
Proteínas Heterotriméricas de Ligação ao GTP/genética
Lipodistrofia/genética
[Mh] Termos MeSH secundário: Animais
Apolipoproteínas E/deficiência
Aterosclerose/metabolismo
Aterosclerose/patologia
Progressão da Doença
Dislipidemias/metabolismo
Dislipidemias/patologia
Fígado Gorduroso/metabolismo
Fígado Gorduroso/patologia
Feminino
Proteínas Heterotriméricas de Ligação ao GTP/deficiência
Lipodistrofia/metabolismo
Lipodistrofia/patologia
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Receptores de LDL/deficiência
Receptores de LDL/genética
Índice de Gravidade de Doença
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (Bscl2 protein, mouse); 0 (Receptors, LDL); EC 3.6.5.1 (Heterotrimeric GTP-Binding Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


  5 / 16223 MEDLINE  
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[PMID]:29357368
[Au] Autor:Yuasa N; Nagata E; Fujii N; Ito M; Tsukamoto H; Takizawa S
[Ad] Endereço:Division of Neurology, Department of Internal Medicine, Isehara Kyodo Hospital, Isehara, Japan.
[Ti] Título:Serum apolipoprotein E may be a novel biomarker of migraine.
[So] Source:PLoS One;13(1):e0190620, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Migraine attacks alter various molecules that might be related to the pathophysiology of migraine, such as serotonin, calcitonin gene-related peptide, and nitric oxide. The underlying pathophysiology of migraine is as yet unclear. We explored key proteins related to the pathogenesis of migraine here. Serum was collected from two patients with migraine with aura (MA) and seven patients with migraine without aura (MO) during attack-free periods and migraine attacks. Samples were analyzed using 2-dimensional gel electrophoresis. Nineteen protein spots were altered between the attack-free versus migraine attack periods. Mass spectrometric analysis was performed to identify the proteins within each of the 19 altered spots. Thirty-six proteins were significantly altered in samples collected during attack-free periods versus migraine attacks. The protein with the statistically most significant MASCOT/Mowse score (268±112) among lipoproteins was apolipoprotein (ApoE). In the MA and MO groups, ApoE protein levels were significantly higher during migraine attack than during the attack-free period (p<0.05). ApoE protein levels were also significantly increased in the MA group during the attack-free period compared to healthy controls and patients with tension type headaches (p<0.01). Migraine alters ApoE levels, especially in MA. ApoE might play an important role in the pathophysiology of migraine, and may act as a diagnostic biomarker of migraine.
[Mh] Termos MeSH primário: Apolipoproteínas E/sangue
Biomarcadores/sangue
Enxaqueca com Aura/sangue
Enxaqueca sem Aura/sangue
[Mh] Termos MeSH secundário: Adulto
Eletroforese em Gel Bidimensional
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Meia-Idade
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190620


  6 / 16223 MEDLINE  
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[PMID]:29202360
[Au] Autor:Woo N; Kim SK; Sun Y; Kang SH
[Ad] Endereço:Department of Chemistry, Graduate School, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea.
[Ti] Título:Enhanced capillary electrophoretic screening of Alzheimer based on direct apolipoprotein E genotyping and one-step multiplex PCR.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1072:290-299, 2018 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Human apolipoprotein E (ApoE) is associated with high cholesterol levels, coronary artery disease, and especially Alzheimer's disease. In this study, we developed an ApoE genotyping and one-step multiplex polymerase chain reaction (PCR) based-capillary electrophoresis (CE) method for the enhanced diagnosis of Alzheimer's. The primer mixture of ApoE genes enabled the performance of direct one-step multiplex PCR from whole blood without DNA purification. The combination of direct ApoE genotyping and one-step multiplex PCR minimized the risk of DNA loss or contamination due to the process of DNA purification. All amplified PCR products with different DNA lengths (112-, 253-, 308-, 444-, and 514-bp DNA) of the ApoE genes were analyzed within 2min by an extended voltage programming (VP)-based CE under the optimal conditions. The extended VP-based CE method was at least 120-180 times faster than conventional slab gel electrophoresis methods In particular, all amplified DNA fragments were detected in less than 10 PCR cycles using a laser-induced fluorescence detector. The detection limits of the ApoE genes were 6.4-62.0pM, which were approximately 100-100,000 times more sensitive than previous Alzheimer's diagnosis methods In addition, the combined one-step multiplex PCR and extended VP-based CE method was also successfully applied to the analysis of ApoE genotypes in Alzheimer's patients and normal samples and confirmed the distribution probability of allele frequencies. This combination of direct one-step multiplex PCR and an extended VP-based CE method should increase the diagnostic reliability of Alzheimer's with high sensitivity and short analysis time even with direct use of whole blood.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico
Doença de Alzheimer/genética
Apolipoproteínas E/genética
Eletroforese Capilar/métodos
Técnicas de Genotipagem/métodos
Reação em Cadeia da Polimerase Multiplex/métodos
[Mh] Termos MeSH secundário: Doença de Alzheimer/sangue
Genótipo
Seres Humanos
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ApoE protein, human); 0 (Apolipoproteins E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  7 / 16223 MEDLINE  
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[PMID]:28744113
[Au] Autor:Youn YC; Lim YK; Han SH; Giau VV; Lee MK; Park KY; Kim S; Bagyinszky E; An SSA; Kim HR
[Ad] Endereço:Department of Neurology.
[Ti] Título:7 allele in memory complaints: insights through protein structure prediction.
[So] Source:Clin Interv Aging;12:1095-1102, 2017.
[Is] ISSN:1178-1998
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:PURPOSE: gene is a rare mutant form of . The mutation occurs in the lipid-binding domain of APOE. Based on the protein's structure, is expected to function in lipid and ß-amyloid metabolism, similar to . However, unlike that for , the mechanisms responsible for Alzheimer's disease (AD) cases associated with expression have not been elucidated. The present study aims to investigate the association between expression and cognitive impairment. METHODS: was sequenced in DNA samples collected from 344 memory-complaint patients who visited the memory clinic, and from 345 non-memory-complaint individuals from the health promotion center. The protein structures of ApoE3, ApoE4, and ApoE7 were predicted. RESULTS: Three / heterozygote individuals who were all classified under the memory-complaint group were identified. Of these, two subjects were clinically diagnosed with AD with small vessel disease, and the remaining individual was diagnosed with subjective cognitive impairment. This study predicted the protein structures of ApoE3, ApoE4, and ApoE7 and determined the three-dimensional structure of the carboxy terminus of ApoE7, which participates in an electrostatic domain interaction similar to that of . K244 or K245 mutations for were not found in the Korean reference genome database, which contains information (http://152.99.75.168/KRGDB/browser/mainBrowser.jsp) from 622 healthy individuals. CONCLUSION: As verified by the results of structural prediction, could serve as another risk factor for cognitive impairment and is particularly associated with vascular disease. However, additional studies are required to validate the pathogenic nature of .
[Mh] Termos MeSH primário: Apolipoproteínas E/genética
Disfunção Cognitiva/genética
[Mh] Termos MeSH secundário: Idoso
Alelos
Doença de Alzheimer/genética
Apolipoproteína E3/genética
Apolipoproteína E4/genética
Feminino
Seres Humanos
Masculino
Memória
Meia-Idade
Resolução de Problemas
República da Coreia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoprotein E3); 0 (Apolipoprotein E4); 0 (Apolipoproteins E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.2147/CIA.S131172


  8 / 16223 MEDLINE  
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[PMID]:28464894
[Au] Autor:Zhao MJ; Wang SS; Jiang Y; Wang Y; Shen H; Xu P; Xiang H; Xiao H
[Ad] Endereço:Nanjing Medical University, Affiliated Nanjing Brain Hospital, No. 264 Guangzhou Road, Nanjing, Jiangsu, 210029, People's Republic of China.
[Ti] Título:Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism.
[So] Source:Lipids Health Dis;16(1):85, 2017 May 02.
[Is] ISSN:1476-511X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The novel compound XH601 is a synthesized derivative of formononetin. The present study was to investigate the hypolipidemia effect and potential mechanism of XH601. METHODS: Male Golden Syrian hamsters were induced by high-fat diet (HFD) for eight weeks and the hyperlipidemic model was established successfully. After XH601 treatment, serum and hepatic biochemistry parameters of hamsters were detected and the effect of XH601 on adipose tissue was also analyzed. Furthermore, 3 T3-L1 cell differentiation by Oil-Red-O staining was observed and the mRNA and protein expression of peroxisome proliferator-activated receptors (PPARs) were measured by qRT-PCR and Western-blot in mature adipocytes. RESULTS: The in vivo results suggest that XH601 significantly decreased the adipose weight and levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), apolipoprotein B (Apo-B), apolipoprotein E (Apo-E), while increased serum high-density lipoprotein (HDL-C). The in vitro results implied that XH601 up-regulated the mRNA and protein expression of both PPARα and PPARß/δ in a dose-dependent manner. CONCLUSIONS: The study suggests that XH601 exhibited strong ability to improve the dyslipidemia in hamsters fed with high-fat diet. The potential mechanism of XH601 was associated with the up-regulation of PPARα and PPARß/δ mRNA and protein expression.
[Mh] Termos MeSH primário: Hiperlipidemias/tratamento farmacológico
Hipolipemiantes/farmacologia
Isoflavonas/farmacologia
PPAR alfa/agonistas
PPAR delta/agonistas
PPAR beta/agonistas
[Mh] Termos MeSH secundário: Células 3T3-L1
Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Tecido Adiposo/patologia
Animais
Apolipoproteínas B/sangue
Apolipoproteínas E/sangue
Diferenciação Celular
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Cricetinae
Dieta Hiperlipídica/efeitos adversos
Regulação da Expressão Gênica
Hiperlipidemias/etiologia
Hiperlipidemias/metabolismo
Hiperlipidemias/patologia
Masculino
Mesocricetus
Camundongos
PPAR alfa/genética
PPAR alfa/metabolismo
PPAR delta/genética
PPAR delta/metabolismo
PPAR beta/genética
PPAR beta/metabolismo
RNA Mensageiro/agonistas
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins B); 0 (Apolipoproteins E); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Hypolipidemic Agents); 0 (Isoflavones); 0 (PPAR alpha); 0 (PPAR delta); 0 (PPAR-beta); 0 (RNA, Messenger); 0 (Triglycerides); 295DQC67BJ (formononetin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12944-017-0472-z


  9 / 16223 MEDLINE  
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[PMID]:29338009
[Au] Autor:Pont I; Calatayud-Pascual A; López-Castellano A; Albelda EP; García-España E; Martí-Bonmatí L; Frias JC; Albelda MT
[Ad] Endereço:Instituto de Ciencia Molecular, Universidad de Valencia, Valencia, Spain.
[Ti] Título:Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice.
[So] Source:PLoS One;13(1):e0190540, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Aterosclerose/tratamento farmacológico
Cicloexanos/uso terapêutico
Modelos Animais de Doenças
Portadores de Fármacos
Ácidos Graxos Insaturados/uso terapêutico
Lipossomos
Nanopartículas
[Mh] Termos MeSH secundário: Inibidores da Angiogênese/administração & dosagem
Animais
Apolipoproteínas E/genética
Aterosclerose/diagnóstico por imagem
Aterosclerose/patologia
Cicloexanos/administração & dosagem
Ácidos Graxos Insaturados/administração & dosagem
Imagem por Ressonância Magnética
Camundongos
Camundongos Knockout
Sesquiterpenos/administração & dosagem
Sesquiterpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Apolipoproteins E); 0 (Cyclohexanes); 0 (Drug Carriers); 0 (Fatty Acids, Unsaturated); 0 (Liposomes); 0 (Sesquiterpenes); 7OW73204U1 (fumagillin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190540


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[PMID]:29197574
[Au] Autor:Li C; Li S; Zhang F; Wu M; Liang H; Song J; Lee C; Chen H
[Ad] Endereço:Department of Cardiology, Peking University People's Hospital, Beijing, 100044, China; Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital, Beijing, 100044, China; Center for Cardiovascular Translational Research, Peking Uni
[Ti] Título:Endothelial microparticles-mediated transfer of microRNA-19b promotes atherosclerosis via activating perivascular adipose tissue inflammation in apoE mice.
[So] Source:Biochem Biophys Res Commun;495(2):1922-1929, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microparticles(MPs) are the major carriers of circulating microRNAs. Our previous study has shown that microRNA (miR)-19b in endothelial cell-derived microparticles (EMPs) is significantly increased in patients with unstable angina. However, little is known about the relationship between miR-19b in EMPs and the progression of atherosclerosis. The aim of the present study was to define the role and potential mechanism of miR-19b incorporated in EMPs in the development of atherosclerosis. Western-diet-fed apoE mice were injected with phosphate buffered solution(PBS), EMP carrying microRNA control(EMP ) or miR-19b mimic (EMP ) intravenously. Systemic treatment with EMP significantly accelerated carotid artery atherosclerosis progression by increasing lipid, macrophages and smooth muscle cells and decreasing collagen content in atherosclerotic plaque. Fluorescence-labelled EMP injection proved that miR-19b could be transported into perivascular adipose tissue(PVAT) by EMPs. EMP treatment also promoted inflammatory cytokines secretion and macrophages infiltration in PVAT. In further experiment, apoE mice were divided into 3 groups: EMP PVAT(+), EMP PVAT(+) and EMP PVAT(-), based on removing or keeping pericarotid adipose tissue and injected with EMP or EMP . Loss of PVAT attenuated EMP -mediated effects on increasing carotid atherosclerosis formation and inflammatory cytokines level in plaque. EMP inhibited suppressor of cytokine signaling 3 (SOCS3) expression in PVAT. Our findings demonstrate that miR-19b in EMPs exaggerates atherosclerosis progression by augmenting PVAT-specific inflammation proceeded by downregulating SOCS3 expression.
[Mh] Termos MeSH primário: Tecido Adiposo/imunologia
Aterosclerose/imunologia
Micropartículas Derivadas de Células/imunologia
Endotélio Vascular/imunologia
MicroRNAs/imunologia
Paniculite/imunologia
[Mh] Termos MeSH secundário: Animais
Apolipoproteínas E/genética
Masculino
Camundongos
Camundongos Knockout
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (MIRN19 microRNA, mouse); 0 (MicroRNAs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE



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