Base de dados : MEDLINE
Pesquisa : D10.570 [Categoria DeCS]
Referências encontradas : 17244 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1725 ir para página                         

  1 / 17244 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460718
[Au] Autor:Libardo MDJ; Wang TY; Pellois JP; Angeles-Boza AM
[Ad] Endereço:Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA.
[Ti] Título:How Does Membrane Oxidation Affect Cell Delivery and Cell Killing?
[So] Source:Trends Biotechnol;35(8):686-690, 2017 08.
[Is] ISSN:1879-3096
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The biophysical properties of cellular membranes intimately influence the delivery of cargoes into cells by cell-penetrating peptides (CPPs) and the bactericidal activity of antimicrobial peptides (AMPs). Here, we discuss how lipid oxidation creates important chemical and biophysical changes in membranes, and hypothesize about the observed synergy between oxidized membranes and membrane-active peptides.
[Mh] Termos MeSH primário: Membrana Celular/química
Peptídeos Penetradores de Células/química
Lipídeos de Membrana/química
[Mh] Termos MeSH secundário: Animais
Membrana Celular/metabolismo
Seres Humanos
Lipídeos de Membrana/metabolismo
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell-Penetrating Peptides); 0 (Membrane Lipids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  2 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29430907
[Au] Autor:Momot TV; Kushnerova NF; Rakhmanin YA
[Ti] Título:[Modification of the pattern of fatty acids of erythrocytes' membranes due to the acetone intoxication].
[So] Source:Gig Sanit;95(8):782-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Results of the study of the impact of acetone intoxication on the fatty acids pattern of the general lipids of erythrocytes' membranes in rats are presented. The inhalation exposure of acetone was carried out in the inoculation chamber with the volume of 100 liters. The chamber was designed for the type of B.A. Kurlyandsky with self-contained system of purification and air regeneration and specified parameters of temperature (20-22С) and air humidity. The flow rate of the air and aerosolized acetone passed through the chamber accounted of 10 liters/min. Concentration of acetone in the chamber was sustained at the level of 206 ± 3,9 mg/m that corresponds to maximum permissible concentration for acetone vapor in the air of a working area. The time of exposure was 6 hours per day for 3 weeks in a monotonous mode, excluding weekend, and was based upon specific parameters of environment simulation in industry. The acetone impact was shown to be accompanied by the gain in the quantity of all kinds of saturated fatty acids and the fall of unsaturated fatty acids in general lipids of erythrocytes ' membranes in rats and in the structure ofphospholipid fractions. In the content of phosphatydilcholine and phosphatydilethanolamine, as a basic structural phospholipids of biological membranes, there was noted the increase in palmitic and stearic acids. In the range offatty acids of the n-6 family the amount of linoleic and arachidonic acids decreased. In the array of fatty acids of the n-3 family the content of linolenic, eicosapentaenoic and docosahexaenoic acids (n-3 family) declined. Redistribution of fatty acids in the erythrocytes membrane towards to such alteration in quantity as the increasing of saturation and decreasing of the unsaturated fatty acids supposes the change of its physical and chemical properties, permeability, lability and complexity of passing erythrocyte via microcircular channels.
[Mh] Termos MeSH primário: Acetona/toxicidade
Membrana Eritrocítica
Ácidos Graxos/metabolismo
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Membrana Eritrocítica/efeitos dos fármacos
Membrana Eritrocítica/metabolismo
Exposição por Inalação/efeitos adversos
Exposição por Inalação/prevenção & controle
Lipídeos de Membrana/metabolismo
Ratos
Solventes/toxicidade
Testes de Toxicidade/métodos
Xenobióticos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Membrane Lipids); 0 (Solvents); 0 (Xenobiotics); 1364PS73AF (Acetone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  3 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29311523
[Au] Autor:Uyama M; Inoue K; Kinoshita K; Miyahara R; Yokoyama H; Nakano M
[Ad] Endereço:Shiseido Global Innovation Center.
[Ti] Título:Effect of Dialkyl Ammonium Cationic Surfactants on the Microfluidity of Membranes Containing Raft Domains.
[So] Source:J Oleo Sci;67(1):67-75, 2018.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:It has been reported that a lot of receptors localize in lipid raft domains and that the microfluidity of these domains regulates the activation of these receptors. In this study, we focused on the lipid raft and in order to evaluate the physicochemical effects of surfactants on microfluidity of lipid membranes, we used liposomes comprising of egg-yolk L-α-phosphatidylcholine, egg-yolk sphingomyelin, and cholesterol as a model of cell membranes containing raft domains. The microfluidity of the domains was characterized by fluorescence spectrometry using 1,6-diphenyl-1,3,5-hexatriene and 2-dimethylamino-6-lauroylnaphthalene. Among several surfactants, dialkylammonium-type cationic surfactants most efficiently increased the microfluidity. It is therefore concluded that (1) the electrostatic interaction between the cationic surfactant and eggPC/eggSM/cholesterol liposome could be important, (2) surfactants with alkyl chains more effectively inserted into membranes than those with acyl chains, and (3) cationic surfactants with lower T values have a greater ability to increase the fluidity.
[Mh] Termos MeSH primário: Compostos de Amônio
Membrana Celular
Fluidez de Membrana
Lipídeos de Membrana
Microdomínios da Membrana
Tensoativos
[Mh] Termos MeSH secundário: Cátions
Fenômenos Químicos
Colesterol
Gema de Ovo
Lipossomos
Fosfatidilcolinas
Espectrometria de Fluorescência
Esfingomielinas
Eletricidade Estática
Tensoativos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Cations); 0 (Liposomes); 0 (Membrane Lipids); 0 (Phosphatidylcholines); 0 (Sphingomyelins); 0 (Surface-Active Agents); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17124


  4 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29235334
[Au] Autor:Khyzhnyak SV; Midyk SV; Sysoliatin SV; Voitsitsky VM
[Ti] Título:Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia.
[So] Source:Ukr Biochem J;88(3):92-8, 2016 May-Jun.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:We studied the influence of hypoxic-hypercapnic environment under the effect of hypothermia (artificial hibernation) on fatty acids spectrum of inner mitochondrial membrane (IMM) lipids of rat cardiomyocytes and hepatocytes. Specific for cellular organelles redistribution of IMM fatty acids was determined. It led to the reduction of total amount of saturated fatty acids (SFAs) and increase of unsaturated fatty acids (UFAs) in cardiomyocytes and to the increase of SFAs and decrease of UFAs in hepatocytes. The decrease in the content of oleic acid and increased content of arachidonic and docosahexaenoic acids in IMM were shown. This may be due to their role in the regulatory systems during hibernation, as well as following exit therefrom. It is assumed that artificial hibernation state is characterized by the stress reaction leading to optimal readjustment of fatty acids composition of membrane lipids, which supports functional activity of mitochondria in hepatocytes and cardiomyocytes.
[Mh] Termos MeSH primário: Ácidos Graxos Insaturados/química
Ácidos Graxos/química
Hepatócitos/metabolismo
Hipercapnia/metabolismo
Hipóxia/metabolismo
Membranas Mitocondriais/metabolismo
Miócitos Cardíacos/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais não Endogâmicos
Ácidos Graxos/classificação
Ácidos Graxos/isolamento & purificação
Ácidos Graxos Insaturados/classificação
Ácidos Graxos Insaturados/isolamento & purificação
Hibernação
Masculino
Lipídeos de Membrana/química
Lipídeos de Membrana/classificação
Lipídeos de Membrana/isolamento & purificação
Mitocôndrias/química
Mitocôndrias/metabolismo
Membranas Mitocondriais/química
Ratos
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Fatty Acids, Unsaturated); 0 (Membrane Lipids)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.03.092


  5 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28455137
[Au] Autor:Ben Mouhoub R; El May A; Cheraief I; Landoulsi A
[Ad] Endereço:Biochemistry and Molecular Biology, Code UR13ES34 Research Unit, Faculty of Sciences of Bizerte, Zarzouna 7021, Carthage University, Tunisia. Electronic address: ramlabenmouhoub@gmail.com.
[Ti] Título:Influence of static magnetic field exposure on fatty acid composition in Salmonella Hadar.
[So] Source:Microb Pathog;108:13-20, 2017 Jul.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have been interested, in this work, to investigate the effect of the exposure to static magnetic field at 200 mT (SMF) on the fatty acid (FA) composition of Salmonella enterica subsp Enterica serovar Hadar isolate 287: effects on the proportion of saturated and unsaturated fatty acids (SFAs, UFAs), cyclopropane fatty acids (CFAs) and hydroxy fatty acids after exposure to the static magnetic field at 200 mT (SMF). Analysis with Gas Chromatography-Mass Spectrometry (GC-MS) of total lipid showed that the proportion of the most fatty acids was clearly affected. The comparison of UFAs/SFAs ratio in exposed bacteria and controls showed a diminution after 3 and 6 h of exposure. This ration reached a balance after 9 h of treatment with SMF. So we can conclude that S. Hadar tries to adapt to magnetic stress by changing the proportions of SFAs and UFAs over time to maintain an equilibrium after 9 h of exposure, thus to maintain the inner membranes fluidity. Also, a decrease in the proportion of hydroxy FAs was observed after 6 h but an increase of this proportion after 9 h of exposure. Concerning CFAs, its proportion raised after 6 h of exposure to the SMF but it decreased after 9 h of exposure. These results are strongly correlated with those of cfa (cyclopropane fatty acid synthase) gene expression which showed a decrease of its expression after 9 h of exposure.
[Mh] Termos MeSH primário: Ácidos Graxos/análise
Campos Magnéticos
Salmonella enterica/metabolismo
Salmonella enterica/efeitos da radiação
[Mh] Termos MeSH secundário: Ciclopropanos/análise
Ciclopropanos/química
Ácidos Graxos/química
Ácidos Graxos/genética
Ácidos Graxos Insaturados/análise
Ácidos Graxos Insaturados/química
Ácidos Graxos Insaturados/genética
Cromatografia Gasosa-Espectrometria de Massas
Regulação Bacteriana da Expressão Gênica/efeitos da radiação
Fluidez de Membrana/efeitos da radiação
Lipídeos de Membrana
Metiltransferases/genética
Metiltransferases/efeitos da radiação
RNA Bacteriano/análise
RNA Ribossômico 16S/genética
Salmonella enterica/genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopropanes); 0 (Fatty Acids); 0 (Fatty Acids, Unsaturated); 0 (Membrane Lipids); 0 (RNA, Bacterial); 0 (RNA, Ribosomal, 16S); 0 (cyclopropane fatty acids); EC 2.1.1.- (Methyltransferases); EC 2.1.1.- (cyclopropane synthetase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  6 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29284244
[Au] Autor:Sagan D; Stepniak J; Gesing A; Lewinski A; Karbownik-Lewinska M
[Ad] Endereço:Department of Oncological Endocrinology, Medical University of Lodz, Lodz, Poland.
[Ti] Título:Melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers - A study in postmenopausal women.
[So] Source:Ann Agric Environ Med;24(4):659-666, 2017 Dec 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION AND OBJECTIVE: Protective antioxidative effects of melatonin have been repeatedly documented in experimental and clinical studies. One of the most spectacular exogenous prooxidative agents is cigarette smoking. The aim of the study was to evaluate the level of oxidative damage to membrane lipids (lipid peroxidation; LPO) in blood serum, and in epidermis exfoliated during microdermabrasion collected from former-smokers who were treated with melatonin. MATERIAL AND METHODS: The study was performed in postmenopausal women. Ninety (90) female volunteers, aged 46-67 years, were enrolled. Two major groups, i.e. never-smokers (n=44) and former-smokers (n=46), were divided into: Control, melatonin topical skin application, Restructurer (containing antioxidants) topical skin application, and melatonin oral treatment. Microdermabrasion was performed at point '0', after 2 weeks, and after 4 weeks of treatment. The following parameters were measured: LPO in blood serum, LPO in epidermis exfoliated during microdermabrasion, and skin biophysical characteristics, such as sebum, moisture, elasticity, and pigmentation. Malondialdehyde+4-hydroxyalkenals level (LPO index) was measured spectrophotometrically. RESULTS: Melatonin oral treatment significantly reversed the increased serum LPO level in former-smokers already after 2 weeks of treatment. In a univariate regression model, LPO blood level constituted the only independent factor negatively associated with melatonin oral treatment. After 4 weeks of treatment, melatonin given orally increased skin sebum, moisture and elasticity levels, and melatonin applied topically increased sebum level. CONCLUSIONS: Exogenous melatonin reverses the enhanced oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.
[Mh] Termos MeSH primário: Fumar Cigarros/efeitos adversos
Melatonina/administração & dosagem
Lipídeos de Membrana/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Pós-Menopausa/metabolismo
Envelhecimento da Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Antioxidantes/metabolismo
Feminino
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Meia-Idade
Pós-Menopausa/efeitos dos fármacos
Pele/efeitos dos fármacos
Pele/metabolismo
Fumantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Membrane Lipids); 4Y8F71G49Q (Malondialdehyde); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE


  7 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29198709
[Au] Autor:Ruan B; Zhang B; Chen A; Yuan L; Liang J; Wang M; Zhang Z; Fan J; Yu X; Zhang X; Niu Z; Zheng Y; Gu S; Liu X; Du H; Wang J; Hu X; Gao L; Chen Z; Huang H; Wang X; Sun Q
[Ad] Endereço:School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510000, PR China; Laboratory of Cell Engineering, Institute of Biotechnology, 20 Dongda Street, Beijing 100071, PR China.
[Ti] Título:Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction.
[So] Source:Biochem Biophys Res Commun;495(1):1440-1446, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell-in-cell structure is prevalent in human cancer, and associated with several specific pathophysiological phenomena. Although cell membrane adhesion molecules were found critical for cell-in-cell formation, the roles of other membrane components, such as lipids, remain to be explored. In this study, we attempted to investigate the effects of cholesterol and phospholipids on the formation of cell-in-cell structures by utilizing liposome as a vector. We found that Lipofectamine-2000, the reagent commonly used for routine transfection, could significantly reduce entotic cell-in-cell formation in a cell-specific manner, which is correlated with suppressed actomyosin contraction as indicated by reduced ß-actin expression and myosin light chain phosphorylation. The influence on cell-in-cell formation was likely dictated by specific liposome components as some liposomes affected cell-in-cell formation while some others didn't. Screening on a limited number of lipids, the major components of liposome, identified phosphatidylethanolamine (PE), stearamide (SA), lysophosphatidic acid (LPA) and cholesterol (CHOL) as the inhibitors of cell-in-cell formation. Importantly, cholesterol treatment significantly inhibited myosin light chain phosphorylation, which resembles the effect of Lipofectamine-2000, suggesting cholesterol might be partially responsible for liposomes' effects on cell-in-cell formation. Together, our findings supporting a role of membrane lipids and cholesterol in cell-in-cell formation probably via regulating actomyosin contraction.
[Mh] Termos MeSH primário: Actomiosina/metabolismo
Membrana Celular/metabolismo
Colesterol/administração & dosagem
Entose/fisiologia
Lipídeos/administração & dosagem
Lipídeos de Membrana/metabolismo
[Mh] Termos MeSH secundário: Actomiosina/efeitos dos fármacos
Entose/efeitos dos fármacos
Seres Humanos
Células MCF-7
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipids); 0 (Lipofectamine); 0 (Membrane Lipids); 9013-26-7 (Actomyosin); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  8 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29262367
[Au] Autor:Baoukina S; Rozmanov D; Tieleman DP
[Ad] Endereço:Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary, Calgary, Alberta, Canada.
[Ti] Título:Composition Fluctuations in Lipid Bilayers.
[So] Source:Biophys J;113(12):2750-2761, 2017 Dec 19.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell membranes contain multiple lipid and protein components having heterogeneous in-plane (lateral) distribution. Nanoscale rafts are believed to play an important functional role, but their phase state-domains of coexisting phases or composition fluctuations-is unknown. As a step toward understanding lateral organization of cell membranes, we investigate the difference between nanoscale domains of coexisting phases and composition fluctuations in lipid bilayers. We simulate model lipid bilayers with the MARTINI coarse-grained force field on length scales of tens of nanometers and timescales of tens of microseconds. We use a binary and a ternary mixture: a saturated and an unsaturated lipid, or a saturated lipid, an unsaturated lipid, and cholesterol, respectively. In these mixtures, the phase behavior can be tuned from a mixed state to a coexistence of a liquid-crystalline and a gel, or a liquid-ordered and a liquid-disordered phase. Transition from a two-phase to a one-phase state is achieved by raising the temperature and adding a hybrid lipid (with a saturated and an unsaturated chain). We analyze the evolution of bilayer properties along this transition: domains of two phases transform to fluctuations with local ordering and compositional demixing. Nanoscale domains and fluctuations differ in several properties, including interleaflet overlap and boundary length. Hybrid lipids show no enrichment at the boundary, but decrease the difference between the coexisting phases by ordering the disordered phase, which could explain their role in cell membranes.
[Mh] Termos MeSH primário: Bicamadas Lipídicas/química
Simulação de Dinâmica Molecular
[Mh] Termos MeSH secundário: Membrana Celular/química
Lipídeos de Membrana/química
Conformação Molecular
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipid Bilayers); 0 (Membrane Lipids)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


  9 / 17244 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29262360
[Au] Autor:Van Eerden FJ; Melo MN; Frederix PWJM; Marrink SJ
[Ad] Endereço:Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Groningen, the Netherlands. Electronic address: floris@vaneerden.eu.
[Ti] Título:Prediction of Thylakoid Lipid Binding Sites on Photosystem II.
[So] Source:Biophys J;113(12):2669-2681, 2017 Dec 19.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The thylakoid membrane has a unique lipid composition, consisting mostly of galactolipids. These thylakoid lipids have important roles in photosynthesis. Here, we investigate to what extent these lipids bind specifically to the Photosystem II complex. To this end, we performed coarse-grain MD simulations of the Photosystem II complex embedded in a thylakoid membrane with realistic composition. Based on >85 µs simulation time, we find that monogalactosyldiacylglycerol and sulfoquinovosyldiacylglycerol lipids are enriched in the annular shell around the protein, and form distinct binding sites. From the analysis of residue contacts, we conclude that electrostatic interactions play an important role in stabilizing these binding sites. Furthermore, we find that chlorophyll a has a prevalent role in the coordination of the lipids. In addition, we observe lipids to diffuse in and out of the plastoquinone exchange cavities, allowing exchange of cocrystallized lipids with the bulk membrane and suggesting a more open nature of the plastoquinone exchange cavity. Together, our data provide a wealth of information on protein-lipid interactions for a key protein in photosynthesis.
[Mh] Termos MeSH primário: Lipídeos de Membrana/metabolismo
Simulação de Dinâmica Molecular
Complexo de Proteína do Fotossistema II/metabolismo
Tilacoides/metabolismo
[Mh] Termos MeSH secundário: Sítios de Ligação
Glicerol/metabolismo
Complexo de Proteína do Fotossistema II/química
Ligação Proteica
Conformação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Lipids); 0 (Photosystem II Protein Complex); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


  10 / 17244 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:29215238
[Au] Autor:Konoplya AI; Shulginova AA
[Ti] Título:[Chronic ischemia of the brain: state structurally functional properties of erythrocytes ].
[So] Source:Patol Fiziol Eksp Ter;60(1):17-22, 2016 Jan-Mar.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:At patients with a chronic ischemia of a brain against an idiopathic hypertensia of the II stage development intra erythrocyte «an oxidative stress¼, depression of sorption ability of erythrocytes, change in a membrane of cells of a ratio of fractions of lipids due to decrease of the maintenance of glitserophospholipid and a sphingomyelin, augmentation of a lizophosphatidilkholin, cholesterol is taped. Change of presentability of the membranous proteins responsible for structurization and stabilization of a membrane of erythrocytes, a shaping, flexibility of a membrane and an intracellular metabolism is established. The important role of erythrocytes at a chronic ischemia of a brain based on the concept of their participation in a chain of the adaptive mechanisms supporting a homeostasis is noted.
[Mh] Termos MeSH primário: Isquemia Encefálica/metabolismo
Membrana Eritrocítica/metabolismo
[Mh] Termos MeSH secundário: Adulto
Isquemia Encefálica/patologia
Doença Crônica
Membrana Eritrocítica/patologia
Feminino
Seres Humanos
Masculino
Lipídeos de Membrana
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Lipids)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE



página 1 de 1725 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde