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  1 / 1144 MEDLINE  
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[PMID]:29195142
[Au] Autor:Tavazzi I; Fontannaz P; Lee LY; Giuffrida F
[Ad] Endereço:Nestlé Research Centre, Lausanne, Switzerland. Electronic address: isabelle.tavazzi@rdls.nestle.com.
[Ti] Título:Quantification of glycerophospholipids and sphingomyelin in human milk and infant formula by high performance liquid chromatography coupled with mass spectrometer detector.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1072:235-243, 2018 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phospholipids and sphingomyelin have a central role in infant nutrition, phospholipid acting as a nutrient carrier of long chain polyunsaturated fatty acids and sphingomyelin having an important role in cognitive function. However, analytical methods to precisely characterize and quantify these compounds in maternal milk are needed. Phospholipids and sphingomyelin were extracted using chloroform and methanol and separated on Polaris 3 Si column 250×2.0mm from Varian and analyzed by high performance liquid chromatography (HPLC) coupled with mass spectrometer detector (MS). The analytical method was validated and repeatability, intermediate reproducibility, and recovery values were calculated. The relative standard deviation of repeatability (CV(r)) and intermediate reproducibility (CV(iR)) values ranged between 2.3 and 7.2% and 9.5 and 17.8%, respectively and the recovery values between 96 and 109%. Finally, the validated method was tested on human milk samples and on infant formula which were analysed also by HPLC coupled with evaporative light scattering detector (ELSD). In human milk, sphingomyelin (9.28mg100mL ) was the most abundant compound, followed by phosphatidylcholine (5.39mg100mL ), phosphatidylethanolamine (2.85mg100mL ) and phosphatidylinositol (1.82mg100mL ).
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Glicerofosfolipídeos/análise
Fórmulas Infantis/química
Espectrometria de Massas/métodos
Leite Humano/química
Esfingomielinas/análise
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); 0 (Sphingomyelins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  2 / 1144 MEDLINE  
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[PMID]:29355496
[Au] Autor:Lee S; Cheung-See-Kit M; Williams TA; Yamout N; Zufferey R
[Ad] Endereço:Department of Biological Sciences, St John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA.
[Ti] Título:The glycosomal alkyl-dihydroxyacetonephosphate synthase TbADS is essential for the synthesis of ether glycerophospholipids in procyclic trypanosomes.
[So] Source:Exp Parasitol;185:71-78, 2018 Feb.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glycerophospholipids are the main constituents of the biological membranes in Trypanosoma brucei, which causes sleeping sickness in humans. The present work reports the characterization of the alkyl-dihydroxyacetonephosphate synthase TbADS that catalyzes the committed step in ether glycerophospholipid biosynthesis. TbADS localizes to the glycosomal lumen. TbADS complemented a null mutant of Leishmania major lacking alkyl-dihydroxyacetonephosphate synthase activity and restored the formation of normal form of the ether lipid based virulence factor lipophosphoglycan. Despite lacking alkyl-dihydroxyacetonephosphate synthase activity, a null mutant of TbADS in procyclic trypanosomes remained viable and exhibited normal growth. Comprehensive analysis of cellular glycerophospholipids showed that TbADS was involved in the biosynthesis of all ether glycerophospholipid species, primarily found in the PE and PC classes.
[Mh] Termos MeSH primário: Alquil e Aril Transferases/metabolismo
Glicerofosfolipídeos/biossíntese
Leishmania major/enzimologia
Microcorpos/enzimologia
Trypanosoma brucei brucei/enzimologia
[Mh] Termos MeSH secundário: Leishmania major/genética
Leishmania major/metabolismo
Mutação com Perda de Função
Plasmídeos/química
Plasmídeos/genética
Plasmídeos/metabolismo
Espectrometria de Massas em Tandem
Trypanosoma brucei brucei/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.26 (alkylglycerone-phosphate synthase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


  3 / 1144 MEDLINE  
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[PMID]:28461680
[Au] Autor:Kohlwein SD
[Ad] Endereço:Institute of Molecular Biosciences, University of Graz, BioTechMed Graz, 8010 Graz, Austria sepp.kohlwein@uni-graz.at.
[Ti] Título:Analyzing and Understanding Lipids of Yeast: A Challenging Endeavor.
[So] Source:Cold Spring Harb Protoc;2017(5):pdb.top078956, 2017 May 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lipids are essential biomolecules with diverse biological functions, ranging from building blocks for all biological membranes to energy substrates, signaling molecules, and protein modifiers. Despite advances in lipid analytics by mass spectrometry, the extraction and quantitative analysis of the diverse classes of lipids are still an experimental challenge. Yeast is a model organism that provides several advantages for studying lipid metabolism, because most biosynthetic pathways are well described and a great deal of information is available on the regulatory mechanisms that control lipid homeostasis. In addition, the composition of yeast lipids is much less complex than that of mammalian lipids, making yeast an excellent reference system for studying lipid-associated cell functions.
[Mh] Termos MeSH primário: Lipídeos/análise
Leveduras/química
[Mh] Termos MeSH secundário: Ácidos Graxos/análise
Glicerofosfolipídeos/análise
Homeostase
Metabolismo dos Lipídeos
Lipídeos/química
Lipídeos/fisiologia
Saccharomyces cerevisiae/química
Especificidade da Espécie
Esfingolipídeos/análise
Esteróis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Glycerophospholipids); 0 (Lipids); 0 (Sphingolipids); 0 (Sterols)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.top078956


  4 / 1144 MEDLINE  
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[PMID]:28461654
[Au] Autor:Knittelfelder OL; Kohlwein SD
[Ad] Endereço:Institute of Molecular Biosciences, University of Graz, BioTechMed Graz, 8010 Graz, Austria.
[Ti] Título:Quantitative Analysis of Yeast Phospholipids and Sterols by High-Performance Liquid Chromatography-Evaporative Light-Scattering Detection.
[So] Source:Cold Spring Harb Protoc;2017(5):pdb.prot085472, 2017 May 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Normal-phase high-performance liquid chromatography (HPLC) is a standard method for separating the major lipid classes in an extract. Owing to the absence of a common property like light absorbance in the various lipid classes, evaporative light-scattering detection (ELSD) is the method of choice for qualitative and quantitative lipid detection. In most cases, neutral lipids and polar lipids are separated by different solvent systems, making it necessary to perform multiple analyses. Compared with other techniques like thin-layer chromatography, normal-phase HPLC-ELSD has better reproducibility and allows a higher degree of automation. Here we describe a method for separating and quantifying yeast neutral lipids and glycerophospholipids in one analytical run.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Fosfolipídeos/análise
Esteróis/análise
[Mh] Termos MeSH secundário: Difusão Dinâmica da Luz
Glicerofosfolipídeos/análise
Glicerofosfolipídeos/isolamento & purificação
Indicadores e Reagentes
Luz
Fosfolipídeos/isolamento & purificação
Reprodutibilidade dos Testes
Espalhamento de Radiação
Esteróis/isolamento & purificação
Leveduras
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); 0 (Indicators and Reagents); 0 (Phospholipids); 0 (Sterols)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.prot085472


  5 / 1144 MEDLINE  
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[PMID]:28461651
[Au] Autor:Knittelfelder OL; Kohlwein SD
[Ad] Endereço:Institute of Molecular Biosciences, University of Graz, BioTechMed Graz, 8010 Graz, Austria.
[Ti] Título:Lipid Extraction from Yeast Cells.
[So] Source:Cold Spring Harb Protoc;2017(5):pdb.prot085449, 2017 May 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The diversity of lipid molecules in biological tissues makes their analysis an experimental challenge. Not only do lipids differ greatly in their chemical structures and biophysical properties, but they also occur in greatly varying concentrations in living cells. Accordingly, even for an organism with a relatively simple lipidome such as yeast, multiple extraction and analysis protocols have been developed because none of them allows comprehensive and quantitative determination of all the diverse molecular lipid species. Here we describe an extraction procedure that results in good yields of neutral lipids and glycerophospholipids from yeast. The resulting samples are suitable for analysis by thin-layer chromatography, gas chromatography/mass spectrometry, or high-performance liquid chromatography.
[Mh] Termos MeSH primário: Lipídeos/isolamento & purificação
Leveduras/química
[Mh] Termos MeSH secundário: Centrifugação/métodos
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Cromatografia Gasosa-Espectrometria de Massas
Glicerofosfolipídeos/isolamento & purificação
Indicadores e Reagentes
Saccharomyces cerevisiae/química
Leveduras/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); 0 (Indicators and Reagents); 0 (Lipids)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.prot085449


  6 / 1144 MEDLINE  
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[PMID]:29182668
[Au] Autor:Buratta S; Urbanelli L; Sagini K; Giovagnoli S; Caponi S; Fioretto D; Mitro N; Caruso D; Emiliani C
[Ad] Endereço:Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
[Ti] Título:Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile.
[So] Source:PLoS One;12(11):e0188840, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cells release extracellular vesicles (EVs) in their environment and cellular lipids play an important role in their formation, secretion and uptake. Besides, there is also evidence that EV transferred lipids impact on recipient's cell signaling. Cellular senescence is characterized by a state of permanent proliferation arrest and represents a barrier towards the development of neoplastic lesions. A peculiar feature of senescence is the release of many soluble factors, the so-called Senescence-Associated Secretory Phenotype, which play a key role in triggering paracrine senescence signals. Recently, evidences have suggested that this phenotype includes not only soluble factors, but also EVs. To identify lipid signatures associated with H-Ras-induced senescence in EVs, we expressed active H-Ras (H-RasV12) in human fibroblasts and investigated how it affects EV release and lipid composition. An enrichment of hydroxylated sphingomyelin, lyso- and ether-linked phospholipids and specific H-Ras-induced senescence signatures, e.g. sphingomyelin, lysophosphatidic acid and sulfatides, were found in EVs compared to cells. Furthermore, H-RasV12 expression in fibroblasts was associated with higher levels of tetraspanins involved in vesicle formation.
[Mh] Termos MeSH primário: Senescência Celular/genética
Vesículas Extracelulares/metabolismo
Fibroblastos/metabolismo
Metabolismo dos Lipídeos
Proteínas ras/metabolismo
[Mh] Termos MeSH secundário: Células Cultivadas
Glicerofosfolipídeos/metabolismo
Seres Humanos
Análise de Componente Principal
Esfingolipídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); 0 (Sphingolipids); EC 3.6.5.2 (ras Proteins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188840


  7 / 1144 MEDLINE  
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[PMID]:28833063
[Au] Autor:Hishikawa D; Valentine WJ; Iizuka-Hishikawa Y; Shindou H; Shimizu T
[Ad] Endereço:Department of Lipid Signaling, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
[Ti] Título:Metabolism and functions of docosahexaenoic acid-containing membrane glycerophospholipids.
[So] Source:FEBS Lett;591(18):2730-2744, 2017 Sep.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Omega-3 (ω-3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to have important roles in human health and disease. Besides being utilized as fuel, ω-3 FAs have specific functions based on their structural characteristics. These functions include serving as ligands for several receptors, precursors of lipid mediators, and components of membrane glycerophospholipids (GPLs). Since ω-3 FAs (especially DHA) are highly flexible, the levels of DHA in GPLs may affect membrane biophysical properties such as fluidity, flexibility, and thickness. Here, we summarize some of the cellular mechanisms for incorporating DHA into membrane GPLs and propose biological effects and functions of DHA-containing membranes of several cell and tissue types.
[Mh] Termos MeSH primário: Ácidos Docosa-Hexaenoicos/química
Glicerofosfolipídeos/química
Glicerofosfolipídeos/metabolismo
[Mh] Termos MeSH secundário: Membrana Celular/metabolismo
Ácido Eicosapentaenoico/química
Ácidos Graxos Ômega-3/química
Fluidez de Membrana/fisiologia
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Fatty Acids, Omega-3); 0 (Glycerophospholipids); 25167-62-8 (Docosahexaenoic Acids); AAN7QOV9EA (Eicosapentaenoic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12825


  8 / 1144 MEDLINE  
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[PMID]:28669639
[Au] Autor:Drzymala-Czyz S; Janich S; Klingler M; Demmelmair J; Walkowiak J; Koletzko B
[Ad] Endereço:Department of Pediatric Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poland.
[Ti] Título:Whole blood glycerophospholipids in dried blood spots - a reliable marker for the fatty acid status.
[So] Source:Chem Phys Lipids;207(Pt A):1-9, 2017 Oct.
[Is] ISSN:1873-2941
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Whole blood total fatty acid analysis in capillary blood has recently been proposed for fatty acid status determination, but the accuracy of this method is affected by the fast turnover of triaclyglyceride (TAG) fatty acids, the individual hematocrit and postprandial state. METHOD: An established method for the glycerophospholipid (GPL) analysis in plasma was adapted for the analysis of whole blood GPL and tested in a fat challenge test. Blood samples were collected from nine participants after receiving a standardised breakfast containing 42g of sunflower oil. Whole blood GPL fatty acids were compared against whole blood total lipid, plasma TAG and phospholipid fatty acids. RESULTS: All fatty acid concentrations in dried blood samples showed a coefficient of variation <5.7%. The fat challenge test induced a significant increase of TAG fatty acid concentration (mean Δ=42.3%±35.7) and whole blood total fatty acid concentration (mean Δ=5.2%±3.7) whereas whole blood GPL fatty acids were hardly changed (mean Δ=1.3%±1.6). CONCLUSION: Whole blood GPL fatty acids are a robust biological marker for the fatty acid status of fasted and non-fasted subjects. The influence of very recent dietary intake on whole blood GPL is smaller than on whole blood total lipids.
[Mh] Termos MeSH primário: Teste em Amostras de Sangue Seco
Ácidos Graxos/sangue
Glicerofosfolipídeos/sangue
[Mh] Termos MeSH secundário: Adulto
Ácido Araquidônico/sangue
Cromatografia Gasosa
Ácidos Docosa-Hexaenoicos/sangue
Feminino
Seres Humanos
Lipídeos/sangue
Masculino
Meia-Idade
Óleos Vegetais/administração & dosagem
Óleos Vegetais/química
Óleo de Girassol
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Glycerophospholipids); 0 (Lipids); 0 (Plant Oils); 0 (Sunflower Oil); 0 (Triglycerides); 25167-62-8 (Docosahexaenoic Acids); 27YG812J1I (Arachidonic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


  9 / 1144 MEDLINE  
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[PMID]:28617863
[Au] Autor:Pantophlet AJ; Roelofsen H; de Vries MP; Gerrits WJJ; van den Borne JJGC; Vonk RJ
[Ad] Endereço:Department of Pediatrics; Center for Liver, Digestive and Metabolic Diseases, University Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
[Ti] Título:The use of metabolic profiling to identify insulin resistance in veal calves.
[So] Source:PLoS One;12(6):e0179612, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heavy veal calves (4-6 months old) are at risk of developing insulin resistance and disturbed glucose homeostasis. Prolonged insulin resistance could lead to metabolic disorders and impaired growth performance. Recently, we discovered that heavy Holstein-Friesian calves raised on a high-lactose or high-fat diet did not differ in insulin sensitivity, that insulin sensitivity was low and 50% of the calves could be considered insulin resistant. Understanding the patho-physiological mechanisms underlying insulin resistance and discovering biomarkers for early diagnosis would be useful for developing prevention strategies. Therefore, we explored plasma metabolic profiling techniques to build models and discover potential biomarkers and pathways that can distinguish between insulin resistant and moderately insulin sensitive veal calves. The calves (n = 14) were classified as insulin resistant (IR) or moderately insulin sensitive (MIS) based on results from a euglycemic-hyperinsulinemic clamp, using a cut-off value (M/I-value <4.4) to identify insulin resistance. Metabolic profiles of fasting plasma samples were analyzed using reversed phase (RP) and hydrophilic interaction (HILIC) liquid chromatography-mass spectrometry (LC-MS). Orthogonal partial least square discriminant analysis was performed to compare metabolic profiles. Insulin sensitivity was on average 2.3x higher (P <0.001) in MIS than IR group. For both RP-LC-MS and HILIC-LC-MS satisfactory models were build (R2Y >90% and Q2Y >66%), which allowed discrimination between MIS and IR calves. A total of 7 and 20 metabolic features (for RP-LC-MS and HILIC-LC-MS respectively) were most responsible for group separation. Of these, 7 metabolites could putatively be identified that differed (P <0.05) between groups (potential biomarkers). Pathway analysis indicated disturbances in glycerophospholipid and sphingolipid metabolism, the glycine, serine and threonine metabolism, and primary bile acid biosynthesis. These results demonstrate that plasma metabolic profiling can be used to identify insulin resistance in veal calves and can lead to underlying mechanisms.
[Mh] Termos MeSH primário: Aminoácidos/sangue
Glicerofosfolipídeos/sangue
Resistência à Insulina
Metaboloma
Esfingolipídeos/sangue
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Bovinos
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Biomarkers); 0 (Glycerophospholipids); 0 (Sphingolipids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179612


  10 / 1144 MEDLINE  
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[PMID]:28439041
[Au] Autor:Dalebroux ZD
[Ad] Endereço:Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA zdalebro@ouhsc.edu.
[Ti] Título:Cues from the Membrane: Bacterial Glycerophospholipids.
[So] Source:J Bacteriol;199(13), 2017 Jul 01.
[Is] ISSN:1098-5530
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this issue of the , V. W. Rowlett et al. unveil new circuitry linking membrane glycerophospholipid (GPL) homeostasis to bacterial stress response and adaptation mechanisms (J Bacteriol 199:e00849-16, 2017, https://doi.org/10.1128/JB.00849-16). Glycerophospholipids comprise critical components of the dual-membrane envelope of Gram-negative bacteria and participate in many processes. The new evidence suggests that, in some instances, distinct GPL molecules function for distinct biochemistry and bacteria sense perturbations in membrane GPL concentrations to coordinate survival strategies. Understanding GPL sensing and remodeling mechanisms will be important moving forward, given the breadth of function for these molecules in bacteriology.
[Mh] Termos MeSH primário: Membrana Celular/fisiologia
Escherichia coli/metabolismo
Regulação Bacteriana da Expressão Gênica/fisiologia
Glicerofosfolipídeos/metabolismo
[Mh] Termos MeSH secundário: Escherichia coli/genética
Glicerofosfolipídeos/genética
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE



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