Base de dados : MEDLINE
Pesquisa : D10.570.877 [Categoria DeCS]
Referências encontradas : 3538 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 354 ir para página                         

  1 / 3538 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28462811
[Au] Autor:Iqbal J; Walsh MT; Hammad SM; Hussain MM
[Ad] Endereço:Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, NY 11203, USA; King Abdullah International Medical Research Center, MNGHA, Al Ahsa 31982, Saudi Arabia.
[Ti] Título:Sphingolipids and Lipoproteins in Health and Metabolic Disorders.
[So] Source:Trends Endocrinol Metab;28(7):506-518, 2017 07.
[Is] ISSN:1879-3061
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders.
[Mh] Termos MeSH primário: Saúde
Lipoproteínas/fisiologia
Doenças Metabólicas/etiologia
Esfingolipídeos/metabolismo
Esfingolipídeos/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Resistência à Insulina/fisiologia
Lipoproteínas/sangue
Lipoproteínas/metabolismo
Doenças Metabólicas/sangue
Doenças Metabólicas/metabolismo
Esfingolipídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Lipoproteins); 0 (Sphingolipids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  2 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29327584
[Au] Autor:Si X; Shang W; Zhou Z; Shui G; Lam SM; Blanchard C; Strappe P
[Ad] Endereço:Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology , Tianjin 300457, China.
[Ti] Título:Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids.
[So] Source:J Agric Food Chem;66(4):881-890, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. ERB-containing diet stimulated butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp., and associated synthesizing enzymes. This altered short-chain fatty acid (SCFA) distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by downregulating orexigenic factors. Together with the enhanced fatty acid ß-oxidation highlighted by Prkaa2, Ppara, and Scd1 expression via AMPK signaling pathway and nonalcoholic fatty liver disease pathway, energy expenditure was positively modulated. Serum lipid compositions showed ERB supplement exhibited a more efficient effect on lowering serum sphingolipids, which was closely associated with the status of insulin resistance. Consistently, genes of Ppp2r3b and Prkcg, involved in the function of ceramides in blocking insulin action, were also downregulated following ERB intervention. Enriched GABA and phenolic acids were supposed to be responsible for the health-beneficial effects.
[Mh] Termos MeSH primário: Metabolismo Energético/efeitos dos fármacos
Alimentos Fortificados
Microbioma Gastrointestinal/efeitos dos fármacos
Resistência à Insulina
Oryza
Ácido gama-Aminobutírico/administração & dosagem
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Ceramidas/fisiologia
DNA/análise
Dieta
Dieta Hiperlipídica
Ácidos Graxos Voláteis/sangue
Microbioma Gastrointestinal/fisiologia
Peptídeo 1 Semelhante ao Glucagon/sangue
Leptina/sangue
Fígado/metabolismo
Masculino
Síndrome Metabólica/etiologia
Síndrome Metabólica/prevenção & controle
Obesidade/terapia
Ratos
Ratos Sprague-Dawley
Sementes
Esfingolipídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ceramides); 0 (Fatty Acids, Volatile); 0 (Leptin); 0 (Sphingolipids); 56-12-2 (gamma-Aminobutyric Acid); 89750-14-1 (Glucagon-Like Peptide 1); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04994


  3 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28461680
[Au] Autor:Kohlwein SD
[Ad] Endereço:Institute of Molecular Biosciences, University of Graz, BioTechMed Graz, 8010 Graz, Austria sepp.kohlwein@uni-graz.at.
[Ti] Título:Analyzing and Understanding Lipids of Yeast: A Challenging Endeavor.
[So] Source:Cold Spring Harb Protoc;2017(5):pdb.top078956, 2017 May 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lipids are essential biomolecules with diverse biological functions, ranging from building blocks for all biological membranes to energy substrates, signaling molecules, and protein modifiers. Despite advances in lipid analytics by mass spectrometry, the extraction and quantitative analysis of the diverse classes of lipids are still an experimental challenge. Yeast is a model organism that provides several advantages for studying lipid metabolism, because most biosynthetic pathways are well described and a great deal of information is available on the regulatory mechanisms that control lipid homeostasis. In addition, the composition of yeast lipids is much less complex than that of mammalian lipids, making yeast an excellent reference system for studying lipid-associated cell functions.
[Mh] Termos MeSH primário: Lipídeos/análise
Leveduras/química
[Mh] Termos MeSH secundário: Ácidos Graxos/análise
Glicerofosfolipídeos/análise
Homeostase
Metabolismo dos Lipídeos
Lipídeos/química
Lipídeos/fisiologia
Saccharomyces cerevisiae/química
Especificidade da Espécie
Esfingolipídeos/análise
Esteróis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Glycerophospholipids); 0 (Lipids); 0 (Sphingolipids); 0 (Sterols)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.top078956


  4 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29242345
[Au] Autor:Lenarcic T; Albert I; Böhm H; Hodnik V; Pirc K; Zavec AB; Podobnik M; Pahovnik D; Zagar E; Pruitt R; Greimel P; Yamaji-Hasegawa A; Kobayashi T; Zienkiewicz A; Gömann J; Mortimer JC; Fang L; Mamode-Cassim A; Deleu M; Lins L; Oecking C; Feussner I; Mongrand S; Anderluh G; Nürnberger T
[Ad] Endereço:Department for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
[Ti] Título:Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins.
[So] Source:Science;358(6369):1431-1434, 2017 12 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Necrosis and ethylene-inducing peptide 1-like (NLP) proteins constitute a superfamily of proteins produced by plant pathogenic bacteria, fungi, and oomycetes. Many NLPs are cytotoxins that facilitate microbial infection of eudicot, but not of monocot plants. Here, we report glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors. Plant mutants with altered GIPC composition were more resistant to NLP toxins. Binding studies and x-ray crystallography showed that NLPs form complexes with terminal monomeric hexose moieties of GIPCs that result in conformational changes within the toxin. Insensitivity to NLP cytolysins of monocot plants may be explained by the length of the GIPC head group and the architecture of the NLP sugar-binding site. We unveil early steps in NLP cytolysin action that determine plant clade-specific toxin selectivity.
[Mh] Termos MeSH primário: Arabidopsis/parasitologia
Citotoxinas/metabolismo
Especificidade de Hospedeiro
Phytophthora/metabolismo
Doenças das Plantas/parasitologia
Pythium/metabolismo
Esfingolipídeos/metabolismo
Toxinas Biológicas/metabolismo
[Mh] Termos MeSH secundário: Sítios de Ligação
Cristalografia por Raios X
Citotoxinas/química
Etilenos/metabolismo
Esfingolipídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Ethylenes); 0 (Sphingolipids); 0 (Toxins, Biological); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aan6874


  5 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743537
[Au] Autor:Deevska GM; Nikolova-Karakashian MN
[Ad] Endereço:University of Pikeville, Kentucky College of Osteopathic Medicine, Pikeville, KY 41501, United States.
[Ti] Título:The expanding role of sphingolipids in lipid droplet biogenesis.
[So] Source:Biochim Biophys Acta;1862(10 Pt B):1155-1165, 2017 10.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sphingolipids are a diverse class of lipids that have regulatory, structural, and metabolic functions. Although chemically distinct from the neutral lipids and the glycerophospholipids, which are the main lipid components of the lipid droplets, sphingolipids have nonetheless been shown to influence lipid droplet formation. The goal of this article is to review the available information and provide a cohesive picture of the role sphingolipids play in lipid droplet biogenesis. The following topics are discussed: (i) the abundance of sphingolipids in lipid droplets and their functional significance; (ii) cross-talk between the synthetic pathways of sphingolipids, glycerophospholipids, and neutral lipids; (iii) the impact of bioactive sphingolipids on TAG synthesis and degradation; (iv) interactions between sphingolipids and other lipid droplet components, like cholesterol esters and proteins; (v) inhibition/genetic deletion of specific sphingolipid metabolic enzymes and the resulting effects on lipid droplet formation in mouse models. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.
[Mh] Termos MeSH primário: Gotículas Lipídicas/metabolismo
Esfingolipídeos/metabolismo
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Camundongos
Esfingolipídeos/genética
Triglicerídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Sphingolipids); 0 (Triglycerides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180106
[Lr] Data última revisão:
180106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  6 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27771292
[Au] Autor:Coant N; Sakamoto W; Mao C; Hannun YA
[Ad] Endereço:Health Science Center, Stony Brook University, 100 Nicolls Road, T15, 023, 11794, Stony Brook, NY, USA. Electronic address: Nicolas.Coant@stonybrookmedicine.edu.
[Ti] Título:Ceramidases, roles in sphingolipid metabolism and in health and disease.
[So] Source:Adv Biol Regul;63:122-131, 2017 Jan.
[Is] ISSN:2212-4934
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over the past three decades, extensive research has been able to determine the biologic functions for the main bioactive sphingolipids, namely ceramide, sphingosine, and sphingosine 1-phosphate (S1P) (Hannun, 1996; Hannun et al., 1986; Okazaki et al., 1989). These studies have managed to define the metabolism, regulation, and function of these bioactive sphingolipids. This emerging body of literature has also implicated bioactive sphingolipids, particularly S1P and ceramide, as key regulators of cellular homeostasis. Ceramidases have the important role of cleaving fatty acid from ceramide and producing sphingosine, thereby controlling the interconversion of these two lipids. Thus far, five human ceramidases encoded by five different genes have been identified: acid ceramidase (AC), neutral ceramidase (NC), alkaline ceramidase 1 (ACER1), alkaline ceramidase 2 (ACER2), and alkaline ceramidase 3 (ACER3). These ceramidases are classified according to their optimal pH for catalytic activity. AC, which is localized to the lysosomal compartment, has been associated with Farber's disease and is involved in the regulation of cell viability. Neutral ceramidase, which is localized to the plasma membrane and primarily expressed in the small intestine and colon, is involved in digestion, and has been implicated in colon carcinogenesis. ACER1 which can be found in the endoplasmic reticulum and is highly expressed in the skin, plays an important role in keratinocyte differentiation. ACER2, localized to the Golgi complex and highly expressed in the placenta, is involved in programed cell death in response to DNA damage. ACER3, also localized to the endoplasmic reticulum and the Golgi complex, is ubiquitously expressed, and is involved in motor coordination-associated Purkinje cell degeneration. This review seeks to consolidate the current knowledge regarding these key cellular players.
[Mh] Termos MeSH primário: Ceramidase Ácida/metabolismo
Ceramidase Alcalina/metabolismo
Ceramidase Neutra/metabolismo
Esfingolipídeos/metabolismo
[Mh] Termos MeSH secundário: Ceramidase Ácida/genética
Ceramidase Alcalina/genética
Animais
Lipogranulomatose de Farber/enzimologia
Lipogranulomatose de Farber/genética
Lipogranulomatose de Farber/patologia
Expressão Gênica
Seres Humanos
Concentração de Íons de Hidrogênio
Inflamação
Cinética
Neoplasias/enzimologia
Neoplasias/genética
Neoplasias/patologia
Doenças Neurodegenerativas/enzimologia
Doenças Neurodegenerativas/genética
Doenças Neurodegenerativas/patologia
Ceramidase Neutra/genética
Transdução de Sinais
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Sphingolipids); EC 3.5.1.23 (ACER1 protein, human); EC 3.5.1.23 (ACER2 protein, human); EC 3.5.1.23 (ACER3 protein, human); EC 3.5.1.23 (Acid Ceramidase); EC 3.5.1.23 (Alkaline Ceramidase); EC 3.5.1.23 (Neutral Ceramidase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  7 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29182668
[Au] Autor:Buratta S; Urbanelli L; Sagini K; Giovagnoli S; Caponi S; Fioretto D; Mitro N; Caruso D; Emiliani C
[Ad] Endereço:Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
[Ti] Título:Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile.
[So] Source:PLoS One;12(11):e0188840, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cells release extracellular vesicles (EVs) in their environment and cellular lipids play an important role in their formation, secretion and uptake. Besides, there is also evidence that EV transferred lipids impact on recipient's cell signaling. Cellular senescence is characterized by a state of permanent proliferation arrest and represents a barrier towards the development of neoplastic lesions. A peculiar feature of senescence is the release of many soluble factors, the so-called Senescence-Associated Secretory Phenotype, which play a key role in triggering paracrine senescence signals. Recently, evidences have suggested that this phenotype includes not only soluble factors, but also EVs. To identify lipid signatures associated with H-Ras-induced senescence in EVs, we expressed active H-Ras (H-RasV12) in human fibroblasts and investigated how it affects EV release and lipid composition. An enrichment of hydroxylated sphingomyelin, lyso- and ether-linked phospholipids and specific H-Ras-induced senescence signatures, e.g. sphingomyelin, lysophosphatidic acid and sulfatides, were found in EVs compared to cells. Furthermore, H-RasV12 expression in fibroblasts was associated with higher levels of tetraspanins involved in vesicle formation.
[Mh] Termos MeSH primário: Senescência Celular/genética
Vesículas Extracelulares/metabolismo
Fibroblastos/metabolismo
Metabolismo dos Lipídeos
Proteínas ras/metabolismo
[Mh] Termos MeSH secundário: Células Cultivadas
Glicerofosfolipídeos/metabolismo
Seres Humanos
Análise de Componente Principal
Esfingolipídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycerophospholipids); 0 (Sphingolipids); EC 3.6.5.2 (ras Proteins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188840


  8 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27773586
[Au] Autor:Nowak A; Mechtler TP; Desnick RJ; Kasper DC
[Ad] Endereço:Department of Internal Medicine, University Hospital Zurich and University of Zurich, Rämistrasse 100, 8091 Zürich, Switzerland. Electronic address: albina.nowak@usz.ch.
[Ti] Título:Plasma LysoGb3: A useful biomarker for the diagnosis and treatment of Fabry disease heterozygotes.
[So] Source:Mol Genet Metab;120(1-2):57-61, 2017 Jan - Feb.
[Is] ISSN:1096-7206
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fabry disease (FD) is a rare X-linked lysosomal storage disorder due to mutations in the α-galactosidase A gene (GLA) that result in absent or markedly reduce α-galactosidase A (α-GalA) enzymatic activity. As a result, the major glycosphingolipid substrates, globotriaosylceramide (Gb3) and globotriaosylsphingosine (LysoGb3) accumulate in plasma, urine and tissue lysosomes. In females, the diagnosis can be complicated by the fact that 40-50% of GLA-mutation confirmed heterozygotes have normal or only slightly decreased leukocyte α-GalA activities. Recently, LysoGb3 has been appreciated as a novel FD biomarker, especially for therapeutic monitoring. METHODS: Among our GLA-mutation proven FD patients, we screened 18 heterozygotes whose leukocyte α-GalA activity was determined at initial diagnosis. For these females, we measured their serum LysoGb3 levels using highly-sensitive electrospray ionization liquid chromatography tandem mass spectrometry. RESULTS: We identified three unrelated females in whom the accumulating LysoGb3 was increased, whereas their leukocyte α-GalA activities were in the normal range. CONCLUSION: LysoGb3 serves as an useful biomarker to improve the diagnosis of FD heterozygotes and for therapeutic evaluation and monitoring.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Doença de Fabry/diagnóstico
Glicolipídeos/sangue
Esfingolipídeos/sangue
alfa-Galactosidase/genética
[Mh] Termos MeSH secundário: Adulto
Criança
Cromatografia Líquida
Doença de Fabry/genética
Doença de Fabry/metabolismo
Feminino
Heterozigoto
Seres Humanos
Meia-Idade
Mutação
Espectrometria de Massas por Ionização por Electrospray
alfa-Galactosidase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glycolipids); 0 (Sphingolipids); 126550-86-5 (globotriaosyl lysosphingolipid); EC 3.2.1.22 (alpha-Galactosidase); EC 3.2.1.22 (alpha-galactosidase A, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  9 / 3538 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28970069
[Au] Autor:Durani LW; Hamezah HS; Ibrahim NF; Yanagisawa D; Makpol S; Damanhuri HA; Tooyama I
[Ad] Endereço:Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu 520-2192, Japan.
[Ti] Título:Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum.
[So] Source:Biochem Biophys Res Commun;493(3):1356-1363, 2017 Nov 25.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have recently shown that age-dependent regional brain atrophy and lateral ventricle expansion may be linked with impaired cognitive and locomotor functions. However, metabolic profile transformation in different brain regions during aging is unknown. This study examined metabolic changes in the hippocampus, medial prefrontal cortex (mPFC) and striatum of middle- and late-aged Sprague-Dawley rats using ultrahigh performance liquid chromatography coupled with high-resolution accurate mass-orbitrap tandem mass spectrometry. Thirty-eight potential metabolites were altered in hippocampus, 29 in mPFC, and 14 in striatum. These alterations indicated that regional metabolic mechanisms in lated-aged rats are related to multiple pathways including glutathione, sphingolipid, tyrosine, and purine metabolism. Thus, our findings might be useful for understanding the complexity of metabolic mechanisms in aging and provide insight for aging and health span.
[Mh] Termos MeSH primário: Corpo Estriado/metabolismo
Hipocampo/metabolismo
Córtex Pré-Frontal/metabolismo
[Mh] Termos MeSH secundário: Envelhecimento/fisiologia
Animais
Cromatografia Líquida de Alta Pressão/métodos
Corpo Estriado/fisiologia
Glutationa/metabolismo
Hipocampo/fisiologia
Masculino
Metaboloma
Córtex Pré-Frontal/fisiologia
Ratos Sprague-Dawley
Esfingolipídeos/metabolismo
Espectrometria de Massas em Tandem/métodos
Tirosina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sphingolipids); 42HK56048U (Tyrosine); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


  10 / 3538 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28895519
[Au] Autor:Kim JM; Lee SA; Cho H; Kim SJ; Joa JH; Kwon SW; Weon HY
[Ad] Endereço:1​Agricultural Microbiology Division, National Institute of Agricultural Sciences (NAS), Rural Development Administration (RDA), Wanju-gun, Jeollabuk-do, 55365, Republic of Korea.
[Ti] Título:Parapedobacter lycopersici sp. nov., isolated from the rhizosphere soil of tomato plants (Solanum lycopersicum L.).
[So] Source:Int J Syst Evol Microbiol;67(10):3728-3732, 2017 Oct.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel Gram-stain-negative bacterial strain, designated T16R-256 , was isolated from the rhizosphere soil of tomato plants grown in a greenhouse in Yecheon-gun, Gyeongsangbuk-do, Republic of Korea and characterized using polyphasic taxonomy. Cells were aerobic, non-flagellated and rod-shaped. Colonies were light yellow, convex and round. The strain grew in the temperature range of 15-37 °C (optimally at 28-30 °C) and pH range of 7.0-9.0 (optimally at 7.0-8.0) and in 4 % NaCl (w/v). A comparison of 16S rRNA gene sequences showed that strain T16R-256 is a member of the genus Parapedobacter, exhibiting high sequence similarity with Parapedobacter pyrenivorans P-4 (94.2 %), Parapedobacter indicus RK1 (93.7 %), Parapedobacter koreensis Jip14 (93.7 %), Parapedobacter luteus 4M29 (93.6 %) and Parapedobacter soli DCY14 (93.4 %). The major polar lipids were phosphatidylethanolamine, sphingolipid, one aminophospholipid, two aminolipids and three unknown lipids. The major fatty acids (>10 % of the total fatty acids) were iso-C15 : 0, iso-C17 : 0 3-OH and iso-C15 : 0 2-OH/C16 : 1ω7c. Strain T16R-256 contained MK-7 as the predominant respiratory quinone and homospermidine as the major polyamine. The genomic DNA G+C content of the type strain was 55.5 mol%. On the basis of phenotypic, chemotaxonomic and phylogenetic data, strain T16R-256 should be designated as representative of a novel species of the genus Parapedobacter, for which the name Parapedobacter lycopersici sp. nov. is proposed. The type strain is T16R-256 (=KACC 18788 =JCM 31602 ).
[Mh] Termos MeSH primário: Bacteroidetes/classificação
Lycopersicon esculentum/microbiologia
Filogenia
Rizosfera
Microbiologia do Solo
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Bacteroidetes/genética
Bacteroidetes/isolamento & purificação
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Fosfatidiletanolaminas/química
Pigmentação
RNA Ribossômico 16S/genética
República da Coreia
Análise de Sequência de DNA
Espermidina/química
Esfingolipídeos/química
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phosphatidylethanolamines); 0 (RNA, Ribosomal, 16S); 0 (Sphingolipids); 11032-49-8 (Vitamin K 2); 39382-08-6 (phosphatidylethanolamine); 8427BML8NY (vitamin MK 7); U87FK77H25 (Spermidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002162



página 1 de 354 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde