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[PMID]:28551268
[Au] Autor:Li Y; Shao X; Xu J; Wei Y; Xu F; Wang H
[Ad] Endereço:Department of Food Science and Engineering, Ningbo University, Ningbo, China.
[Ti] Título:Tea tree oil exhibits antifungal activity against Botrytis cinerea by affecting mitochondria.
[So] Source:Food Chem;234:62-67, 2017 Nov 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In order to investigate the effects of tea tree oil (TTO) on mitochondrial morphology and function in Botrytis cinerea, mycelia were treated with TTO at different concentrations. TTO at 2ml/l severely damaged mitochondria, resulting in matrix loss and increased mitochondrial irregularity. Mitochondrial membrane permeability was increased by TTO, as evidenced by a decrease in intracellular adenosine triphosphate (ATP) content and an increase in extracellular ATP content. Increasing concentrations of TTO decreased the activities of enzymes related to mitochondrial function and the tricarboxylic acid (TCA) cycle, affecting malic dehydrogenase, succinate dehydrogenase, ATPase, citrate synthetase, isocitrate dehydrogenase and α-ketoglutarate dehydrogenase, while sharply increasing the level of reactive oxygen species (ROS). These results suggest that mitochondrial damage, resulting in the disruption of the TCA cycle and accumulation of ROS, is involved in the mechanism of TTO antifungal activity against B. cinerea.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Botrytis/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Óleo de Melaleuca/farmacologia
[Mh] Termos MeSH secundário: Ciclo do Ácido Cítrico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28379241
[Au] Autor:Zhu Z; Lin Z; Jiang H; Jiang Y; Zhao M; Liu X
[Ad] Endereço:College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China. zmmgxu@gxu.edu.cn 1106133912@qq.com 769375931@qq.com 349360402@qq.com 847702770@qq.com 1083183501@qq.com.
[Ti] Título:Hypolipidemic effect of Youcha in hyperlipidemia rats induced by high-fat diet.
[So] Source:Food Funct;8(4):1680-1687, 2017 Apr 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Youcha is a novel tea drink from the northeast of Guangxi. This study aimed to investigate the hypolipidemic properties of Youcha in high-fat induced hyperlipidemic Sprague-Dawley (SD) rats. After designing the model, rats were randomly divided into six groups (n = 10): normal diet (NMD) group, high-fat diet (HFD) group, Xuezhikang (120 mg kg d ) (HFD+P) group and Youcha (150, 750 or 1500 mg kg d ) (HFD+L, HFD+M or HFD+H) groups. Youcha comprises tea polyphenols (1.51 g per 100 g), caffeine (34.80 mg per 100 g) and other functional compounds. To evaluate the lipid-lowering effects of Youcha, weight of the body, liver and fat, fat index, lipid metabolism, antioxidant properties and liver damage indices were examined. In addition, the activities of some enzymes in serum and liver tissue were examined to preliminarily study their possible mechanism. The results reveal that Youcha tends to reduce body weight, liver weight, fat index, total cholesterol (TC) and triglyceride (TG) contents, low-density lipoprotein cholesterol (LDL-C), atherogenic index (AI), malondialdehyde (MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and increase high-density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) and glutathione peroxidase (GPx) relative to the HFD group. The hypolipidemic effect was partly due to the regulation of fatty acid synthetase (FAS) and lipase (LPS) rather than lipoprotein lipase (LPL) to decrease TG markedly. These findings suggest that Youcha could be potentially used to remedy hyperlipidemia and is hence worthy of promotion as a tea drink.
[Mh] Termos MeSH primário: Alho/química
Gengibre/química
Hiperlipidemias/tratamento farmacológico
Hipolipemiantes/administração & dosagem
Preparações de Plantas/administração & dosagem
Óleo de Melaleuca/química
[Mh] Termos MeSH secundário: Animais
Dieta Hiperlipídica/efeitos adversos
Seres Humanos
Hiperlipidemias/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Chá/química
Óleo de Melaleuca/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypolipidemic Agents); 0 (Plant Preparations); 0 (Tea); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00089h


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[PMID]:28177805
[Au] Autor:Li Y; Shao X; Xu J; Wei Y; Xu F; Wang H
[Ad] Endereço:Department of Food Science and Engineering, Ningbo University, Ningbo, People's Republic of China.
[Ti] Título:Effects and possible mechanism of tea tree oil against Botrytis cinerea and Penicillium expansum in vitro and in vivo test.
[So] Source:Can J Microbiol;63(3):219-227, 2017 Mar.
[Is] ISSN:1480-3275
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the antifungal activities and possible mechanisms of tea tree oil (TTO) against Botrytis cinerea and Penicillium expansum in vitro and in vivo. The results show that TTO exhibits dose-dependent antifungal activity against both pathogens, but P. expansum is less sensitive than B. cinerea to TTO not only in the in vitro test but also in artificially inoculated cherry fruits. TTO vapor treatment reduced the decay caused by these pathogens in inoculated cherry fruits, but the effect on P. expansum was less than that on B. cinerea. While the total lipid and ergosterol contents of the cell membrane are greater in P. expansum than in B. cinerea, TTO treatment lowers the total lipid content in the membranes of both species by well over 50%, and ergosterol content is reduced to a greater extent in B. cinerea than in P. expansum. In both pathogens, TTO alters mycelial morphology and cellular ultrastructure. Oxygen consumption measurements show that TTO inhibits respiratory metabolism via the tricarboxylic acid cycle pathway in both pathogens, though more severely in B. cinerea than in P. expansum. The relatively decreased sensitivity of P. expansum to TTO may be due to the fact that TTO causes less disruption of the cell membrane in this organism, and higher inhibition the respiratory metabolism to the extent observed in B. cinerea.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Botrytis/efeitos dos fármacos
Penicillium/efeitos dos fármacos
Óleo de Melaleuca/farmacologia
[Mh] Termos MeSH secundário: Frutas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1139/cjm-2016-0553


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[PMID]:28124137
[Au] Autor:Hadas E; Derda M; Cholewinski M
[Ad] Endereço:Department of Biology and Medical Parasitology, Poznan University of Medical Sciences, 10 Fredry Street, 61-701, Poznan, Poland.
[Ti] Título:Evaluation of the effectiveness of tea tree oil in treatment of Acanthamoeba infection.
[So] Source:Parasitol Res;116(3):997-1001, 2017 Mar.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Eye diseases caused by amoebae from the genus Acanthamoeba are usually chronic and severe, and their treatment is prolonged and not very effective. The difficulties associated with therapy have led to attempts at finding alternative treatment methods. Particularly popular is searching for cures among drugs made of plants. However, no substances with total efficacy in treating Acanthamoeba keratitis have been identified.Results of our semi in vivo studies of tea tree oil simulating eyeball infection demonstrated 100% effectiveness in the case of both trophozoites and cysts of amoebae from the genus Acanthamoeba. The action of tea tree oil indicates that this is the first substance with a potential ability to quickly and effectively remove the amoebae from the eye. Tea tree oil has the ability to penetrate tissues, which allows it to destroy amoebae in both the shallow and deep layers of the cornea. The present research into the use of tea tree oil in the therapy of Acanthamoeba infection is the first study of this type in parasitology. It offers tremendous potential for effective treatment of Acanthamoeba keratitis and other diseases caused by these protozoa.
[Mh] Termos MeSH primário: Ceratite por Acanthamoeba/tratamento farmacológico
Acanthamoeba/efeitos dos fármacos
Melaleuca/química
Óleo de Melaleuca/farmacologia
[Mh] Termos MeSH secundário: Acanthamoeba/fisiologia
Ceratite por Acanthamoeba/parasitologia
Animais
Córnea/parasitologia
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Óleos Vegetais/farmacologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-017-5377-2


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[PMID]:27988310
[Au] Autor:Baldissera MD; Souza CF; Júnior GB; de Vargas AC; Boligon AA; de Campos MM; Stefani LM; Baldisserotto B
[Ad] Endereço:Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address: matheusd.biomed@yahoo.com.br.
[Ti] Título:Melaleuca alternifolia essential oil enhances the non-specific immune system and prevents oxidative damage in Rhamdia quelen experimentally infected by Aeromonas hydrophila: Effects on cholinergic and purinergic systems in liver tissue.
[So] Source:Fish Shellfish Immunol;61:1-8, 2017 Feb.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the effects of M. alternifolia essential oil used to treat silver catfish (Rhamdia quelen) experimentally infected by Aeromonas hydrophila on oxidative stress variables, and for the first time, on hepatic enzymes of the cholinergic and adenosinergic systems. For that, fish were divided into six groups (A-F), each containing seven animals. Groups A, B and C were composed of uninfected animals, while animals in groups D, E and F were intramuscularly inoculated with A. hydrophila. Groups B and E received a prophylactic bath with M. alternifolia essential oil (50 µL/L, diluted in ethanol) for seven days, while groups C and F were exposed to ethanol. After the prophylactic baths, groups D, E and F were inoculated with 100 µL of A. hydrophila solution (2.1 × 10 colony-forming unit). Two days after inoculation, the animals were euthanized and liver samples were collected. Infected animals (the group D) showed increased TBARS and protein carbonylation levels, while CAT, AChE and ADA activities decreased compared to uninfected animals (the group A). The prophylactic treatment with M. alternifolia essential oil (the group E) prevented the alterations caused by A. hydrophila, but it did not change AChE activity. Thus, the prophylactic treatment prevents damage caused by lipids and proteins, as well as alterations of the adenosinergic system, demonstrating that the anti-inflammatory effect of TTO is mediated by the adenosinergic pathway. In addition, TTO prophylactic treatment might be considered an important approach to prevent the hepatic damage caused by A. hydrophila.
[Mh] Termos MeSH primário: Peixes-Gato
Doenças dos Peixes/genética
Infecções por Bactérias Gram-Negativas/veterinária
Melaleuca/química
Estresse Oxidativo/efeitos dos fármacos
Óleo de Melaleuca/farmacologia
[Mh] Termos MeSH secundário: Aeromonas hydrophila/fisiologia
Animais
Doenças dos Peixes/imunologia
Doenças dos Peixes/microbiologia
Infecções por Bactérias Gram-Negativas/genética
Infecções por Bactérias Gram-Negativas/imunologia
Infecções por Bactérias Gram-Negativas/microbiologia
Imunidade Inata/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE


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[PMID]:27979118
[Au] Autor:Shrestha M; Ho TM; Bhandari BR
[Ad] Endereço:School of Agriculture and Food Sciences, The University of Queensland, QLD 4072, Australia.
[Ti] Título:Encapsulation of tea tree oil by amorphous beta-cyclodextrin powder.
[So] Source:Food Chem;221:1474-1483, 2017 Apr 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An innovative method to encapsulate tea tree oil (TTO) by direct complexation with solid amorphous beta-cyclodextrin (ß-CD) was investigated. A ß-CD to TTO ratio of 90.5:9.5 (104.9mg TTO/g ß-CD) was used in all complexation methods. The encapsulation was performed by direct mixing, and direct mixing was followed by the addition of water (13-17% moisture content, MC) or absolute ethanol (1:1, 1:2, 1:3 and 1:4 TTO:ethanol). The direct mixing method complexed the lowest amount of TTO (60.77mg TTO/g ß-CD). Powder recrystallized using 17% MC included 99.63mg of TTO/g ß-CD. The addition of ethanol at 1:2 and 1:3 TTO:ethanol ratios resulted in the inclusion of 94.3 and 98.45mg of TTO/g ß-CD respectively, which was similar to that of TTO encapsulated in the conventional paste method (95.56mg TTO/g ß-CD), suggesting an effective solid encapsulation method. The XRD and DSC results indicated that the amorphous TTO-ß-CD complex was crystallized by the addition of water and ethanol.
[Mh] Termos MeSH primário: Etanol/química
Óleo de Melaleuca/química
beta-Ciclodextrinas/química
[Mh] Termos MeSH secundário: Pós
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Powders); 0 (beta-Cyclodextrins); 3K9958V90M (Ethanol); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27762176
[Au] Autor:Monteiro DU; Azevedo MI; Weiblen C; DE Avila Botton S; Funk NL; DE Bona DA Silva C; Zanette RA; Schwanz TG; DE LA Rue ML
[Ad] Endereço:Postgraduation Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil.
[Ti] Título:In vitro and ex vivo activity of Melaleuca alternifolia against protoscoleces of Echinococcus ortleppi.
[So] Source:Parasitology;144(2):214-219, 2017 Feb.
[Is] ISSN:1469-8161
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cystic echinococcosis is a zoonotic disease of difficult diagnosis and treatment. The use of protoscolicidal agents in procedures is of utmost importance for treatment success. This study was aimed at analysing the in vitro and ex vivo activity of Melaleuca alternifolia oil (tea tree oil - TTO), its nanoemulsion formulation (NE-TTO) and its major component (terpinen-4-ol) against Echinococcus ortleppi protoscoleces obtained from cattle. Concentrations of 2·5, 5 and 10 mg mL-1 of TTO, 10 mg mL-1 of NE-TTO and 1, 1·5 and 2 mg mL-1 of terpinen-4-ol were evaluated in vitro against protoscoleces at 5, 10, 15 and 30 min. TTO was also injected directly into hydatid cysts (ex vivo analysis, n = 20) and the viability of protoscoleces was evaluated at 5, 15 and 30 min. The results indicated protoscolicidal effect at all tested formulations and concentrations. Terpinen-4-ol (2 mg mL-1) activity was superior when compared with the highest concentration of TTO. NE-TTO reached a gradual protoscolicidal effect. TTO at 20 mg mL-1 showed 90% protoscolicidal action in hydatid cysts at 5 min. The results showed that TTO affects the viability of E. ortleppi protoscoleces, suggesting a new protoscolicidal option to the treatment of cystic equinococcosis.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Echinococcus/efeitos dos fármacos
Melaleuca
Óleo de Melaleuca/farmacologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1017/S0031182016001621


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[PMID]:27707640
[Au] Autor:Cho YS; Choi YH
[Ad] Endereço:Department of Emergency Medicine, College of Medicine, Soonchunhyang University, Republic of Korea.
[Ti] Título:Comparison of three cooling methods for burn patients: A randomized clinical trial.
[So] Source:Burns;43(3):502-508, 2017 May.
[Is] ISSN:1879-1409
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Tap water may not be readily available in numerous places as a first aid for burns and, therefore, tea tree oil products are recommended alternatives. Our aim in this study was to compare the cooling effects of three burn-cooling methodologies, running tap water, Burnshield , and Burn Cool Spray , and suggest indications for each cooling method. This randomized, controlled, study enrolled patients with burns who used the emergency service of Seoul Bestian Hospital from June 2015 to October 2015. The allocation of the cooling methods was randomly generated using a computer. We cooled the burn wounds by applying one of the three methods and measured the skin surface temperature and pain level using a visual analog scale (VAS) scoring. Ninety-six patients were enrolled in this study. The variability in the median(IQR) skin temperatures of the three groups was from 33.5°C (31.5-35.0) to 28.7°C (25.9-30.9), 33.8°C (32.0-35.4) to 33.2°C (30.5-35.0), and 34.0°C (32.0-35.1) to 34.4°C (32.7-35.6) for the tap water, Burn Cool Spray , and Burnshield , respectively. The variability of the mean VAS pain scores was 6.9 to 4.8 (tap water), 5.6 to 4.5 (Burn Cool Spray ), and 5.5 to 3.3 (Burnshield ). The reduction of skin surface temperature by tap water was significantly greater than that by the other two methods. All three methods reduced the VAS pain score after 20min of treatment (p<0.001). The tap water had a similar effect to that of the Burn Cool Spray but significantly better than that of Burnshield . There was a significant difference in the skin surface temperature and VAS pain score reduction (p=0.014 and p=0.007, respectively) between the groups cooled by tap water below and above 24°C. The patients who visited the center within 30min showed a significantly higher skin temperature than those who came after 30min did (p=0.033). Tap water and Burn Cool Spray reduced the skin surface temperature, but the Burnshield slightly increased it. All three cooling methods were effective in relieving pain. The temperature of the tap water used was related to the reduction in skin surface temperature and VAS pain score. The patients who visited the hospital within 30min of their burn accident needed a longer cooling time to attain a comparable skin surface temperature to those who visited after 30min.
[Mh] Termos MeSH primário: Bandagens
Queimaduras/terapia
Primeiros Socorros/métodos
Manejo da Dor
Temperatura Cutânea
Óleo de Melaleuca/uso terapêutico
Tempo para o Tratamento
Água
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
República da Coreia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
059QF0KO0R (Water); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE


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[PMID]:27146784
[Au] Autor:Low WL; Kenward K; Britland ST; Amin MC; Martin C
[Ad] Endereço:School of Pharmacy, University of Wolverhampton, Wolverhampton, UK.
[Ti] Título:Essential oils and metal ions as alternative antimicrobial agents: a focus on tea tree oil and silver.
[So] Source:Int Wound J;14(2):369-384, 2017 Apr.
[Is] ISSN:1742-481X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The increasing occurrence of hospital-acquired infections and the emerging problems posed by antibiotic-resistant microbial strains have both contributed to the escalating cost of treatment. The presence of infection at the wound site can potentially stall the healing process at the inflammatory stage, leading to the development of a chronic wound. Traditional wound treatment regimes can no longer cope with the complications posed by antibiotic-resistant strains; hence, there is a need to explore the use of alternative antimicrobial agents. Pre-antibiotic compounds, including heavy metal ions and essential oils, have been re-investigated for their potential use as effective antimicrobial agents. Essential oils have potent antimicrobial, antifungal, antiviral, anti-inflammatory, antioxidant and other beneficial therapeutic properties. Similarly, heavy metal ions have also been used as disinfecting agents because of their broad spectrum activities. Both of these alternative antimicrobials interact with many different intracellular components, thereby resulting in the disruption of vital cell functions and eventually cell death. This review will discuss the application of essential oils and heavy metal ions, particularly tea tree oil and silver ions, as alternative antimicrobial agents for the treatment of chronic, infected wounds.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Anti-Infecciosos/uso terapêutico
Óleos Voláteis/uso terapêutico
Fitoterapia
Prata/uso terapêutico
Óleo de Melaleuca/uso terapêutico
Infecção dos Ferimentos/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Terapias Complementares
Farmacorresistência Bacteriana/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Oils, Volatile); 3M4G523W1G (Silver); 68647-73-4 (Tea Tree Oil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1111/iwj.12611


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[PMID]:27092733
[Au] Autor:Rajkowska K; Kunicka-Styczynska A; Maroszynska M
[Ad] Endereço:1 Faculty of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Lodz University of Technology , Lodz, Poland .
[Ti] Título:Selected Essential Oils as Antifungal Agents Against Antibiotic-Resistant Candida spp.: In Vitro Study on Clinical and Food-Borne Isolates.
[So] Source:Microb Drug Resist;23(1):18-24, 2017 Jan.
[Is] ISSN:1931-8448
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Candida spp. cause significant health problems, inducing various types of superficial and deep-seated mycoses in humans. As a result of the increasing antibiotic resistance among pathogenic yeasts, the interest in alternative agents of antifungal activity is growing. This study evaluated the antimicrobial activity of selected essential oils (EOs) against Candida clinical and food-borne strains, including antibiotic-resistant isolates, in relation to yeast cell surface hydrophobicity (CSH). Candida strains showed different range of susceptibility to tea tree, thyme, peppermint, and clove oils, and peppermint oil demonstrated the lowest anticandidal activity with minimal inhibitory concentrations (MICs) of 0.03-8.0% v/v. MIC values for thyme and clove oils ranged from 0.03% to 0.25% v/v, and for tea tree oil-from 0.12% to 2.0% v/v. The exception was Candida tropicalis food-borne strain, the growth of which was inhibited after application of EOs at concentration of 8% v/v. Due to diverse yeast susceptibility to EOs, isolates were divided into five clusters in a principal component analysis model, each containing both clinical and food-borne strains. Hydrophobic properties of yeast were also diversified, and 37% of clinical and 50% of food-borne strains exhibited high hydrophobicity. The study indicates high homology of clinical and food-borne Candida isolates in relation to their susceptibility to anticandidal agents and hydrophobic properties. The susceptibility of yeasts to EOs could be partially related to their CSH. High antifungal activity of examined EOs, also against antibiotic-resistant isolates, indicates their usefulness as agents preventing the development of Candida strains of different origin.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida/efeitos dos fármacos
Óleo de Cravo/farmacologia
Óleos Vegetais/farmacologia
Óleo de Melaleuca/farmacologia
Thymus (Planta)/química
[Mh] Termos MeSH secundário: Antifúngicos/química
Candida/química
Candida/crescimento & desenvolvimento
Candida/isolamento & purificação
Candidíase/microbiologia
Membrana Celular/química
Membrana Celular/efeitos dos fármacos
Parede Celular/química
Parede Celular/efeitos dos fármacos
Óleo de Cravo/química
Farmacorresistência Fúngica Múltipla/efeitos dos fármacos
Doenças Transmitidas por Alimentos/microbiologia
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Testes de Sensibilidade Microbiana
Óleos Vegetais/química
Análise de Componente Principal
Propriedades de Superfície
Óleo de Melaleuca/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Clove Oil); 0 (Plant Oils); 68647-73-4 (Tea Tree Oil); AV092KU4JH (peppermint oil)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1089/mdr.2016.0001



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