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  1 / 1093 MEDLINE  
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[PMID]:28720131
[Au] Autor:Alamgeer; Uttra AM; Hasan UH
[Ad] Endereço:Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University Of Sargodha, Sargodha, Pakistan. alam_yuchi@yahoo.com.
[Ti] Título:Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch.
[So] Source:BMC Complement Altern Med;17(1):371, 2017 Jul 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The roots and stem bark of Berberis orthobotrys (Berberidaceae) have long been used traditionally to treat joint pain. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores anti-arthritic activity and phytochemical analysis of aqueous-methanolic extract (30:70) and fractions (ethyl acetate, n-butanol, and aqueous) of Berberis orthobotrys roots. METHODS: Anti-arthritic potential was evaluated in vitro using protein denaturation (bovine serum albumin and egg albumin) and membrane stabilization methods at 12.5-800 µg/ml concentration and in vivo via turpentine oil, formaldehyde and Complete Freund Adjuvant (CFA) models at 50, 100 and 150 mg/kg doses. Also, in vitro antioxidant ability was appraised by reducing power assay. Moreover, total flavonoid content, Fourier transform infrared spectroscopy and High performance liquid chromatography of n-butanol fraction were performed. RESULTS: The results revealed concentration dependent inhibition of albumin denaturation and notable RBC membrane stabilization, with maximum results obtained at 800 µg/ml. Similarly, plant exhibited dose dependent anti-arthritic effect in turpentine oil and formaldehyde models, with maximum activity observed at 150 mg/kg. The results of CFA model depicted better protection against arthritic lesions and body weight alterations. Also, B.orthobotrys remarkably ameliorated altered hematological parameters, rheumatoid factor and positively modified radiographic and histopathological changes. Additionally, plant exhibited remarkable anti-oxidant activity. Moreover, phytochemical analysis revealed polyphenols and flavonoids. CONCLUSION: Taken together, these results support traditional use of B.orthobotrys as potent anti-arthritic agent that may be proposed for rheumatoid arthritis treatment.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Experimental/tratamento farmacológico
Artrite Reumatoide
Berberis/química
Fitoterapia
Extratos Vegetais/uso terapêutico
Polifenóis/uso terapêutico
[Mh] Termos MeSH secundário: Albuminas/metabolismo
Animais
Antioxidantes/análise
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Antirreumáticos/farmacologia
Artrite Reumatoide/sangue
Artrite Reumatoide/tratamento farmacológico
Bovinos
Membrana Celular/efeitos dos fármacos
Eritrócitos
Feminino
Flavonoides/análise
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Formaldeído
Adjuvante de Freund
Masculino
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Estruturas Vegetais
Polifenóis/análise
Polifenóis/farmacologia
Desnaturação Proteica
Ratos Sprague-Dawley
Fator Reumatoide/sangue
Albumina Sérica/metabolismo
Terebintina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Antioxidants); 0 (Antirheumatic Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Serum Albumin); 1HG84L3525 (Formaldehyde); 8006-64-2 (Turpentine); 9007-81-2 (Freund's Adjuvant); 9009-79-4 (Rheumatoid Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1879-9


  2 / 1093 MEDLINE  
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[PMID]:28114804
[Au] Autor:Zhu SJ; Xu SC; Zhao ZD
[Ad] Endereço:a Institute of Chemical Industry of Forest Products , CAF , Nanjing , China.
[Ti] Título:An efficient synthesis method targeted to a novel aziridine derivative of p-menthane from turpentine and its herbicidal activity.
[So] Source:Nat Prod Res;31(13):1536-1543, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel aziridine compound N-acetyl-1,2-azacyclo-p-menthane d was synthesised using turpentine as raw material and characterised by FT-IR, H NMR, C NMR, ESI -MS and HRMS. The pre-emergence herbicidal activities of d and its synthetic intermediates cis- and trans-N,N'-diacetyl-p-menthane-1,8-diamine (b2 and b1) were determined. The result showed that d exhibited much higher herbicidal activities against annual ryegrass, Digitaria sanguinalis and Ixeris denticulate than b2 and b1. The IC of d against the root and shoot growth of these three plants were lower than 1 mmol L . In contrast, the IC of b1 and b2 against the root and shoot growth of these plants were more than 10 mmol L .
[Mh] Termos MeSH primário: Aziridinas/síntese química
Aziridinas/farmacologia
Herbicidas/síntese química
Terebintina/química
[Mh] Termos MeSH secundário: Herbicidas/química
Herbicidas/farmacologia
Mentol/análogos & derivados
Mentol/química
Plantas/efeitos dos fármacos
Espectroscopia de Infravermelho com Transformada de Fourier
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aziridines); 0 (Herbicides); 1490-04-6 (Menthol); 54P5FEX9FH (aziridine); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1280494


  3 / 1093 MEDLINE  
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[PMID]:27213946
[Au] Autor:Garnov IO; Kuchin AV; Loginova TP; Varlamova NG; Boiko ER
[Ad] Endereço:Federal state budgetary institution of science 'Institute of Physiology', Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.
[Ti] Título:[The application of the emulsified turpentine baths for the correction of the functional state of the cross-country skiers].
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;93(2):26-31, 2016 Mar-Apr.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The baths with emulsified turpentine find the wide application in balneotherapy. They produce especially pronounced beneficial prophylactic effects in the patients presenting with microtrombosis and microvascular stasis. Moreover, these baths may be prescribed to improve microcirculation, increase the functional reserves and physical capacity in the athletes. At the same time, the current literature appears to contain no scientific publications on the application of emulsified turpentine baths for the restoration of the physical capacity of the professional ski runners. The lack of relevant information motivated the study reported in the present article. The main objective of the study involving 10 subjects was to evaluate the effectiveness of the modified emulsified turpentine baths as a method by which to restore and enhance the physical capacity of the professional cross-country skiers. The physical capacity of the athletes was evaluated from the results of the bicycle ergometer exercise test with the use of the «Oxycon Pro¼ system. The data obtained suggest that a course of the emulsified turpentine baths increases the activity of the cardiorespiratory system, improves the physical capacity, and enhances the functional reserves of the body in the anaerobic zone.
[Mh] Termos MeSH primário: Banhos/métodos
Esqui
Medicina Esportiva/métodos
Terebintina/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Emulsões
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.17116/kurort2016226-31


  4 / 1093 MEDLINE  
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[PMID]:27150277
[Au] Autor:Mirzaei A; Jalilian AR; Akhlaghi M; Beiki D
[Ti] Título:Production of 68Ga-citrate Based on a SnO2 Generator for Short-Term Turpentine Oil-Induced Inflammation Imaging in Rats.
[So] Source:Curr Radiopharm;9(3):208-214, 2016.
[Is] ISSN:1874-4729
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Gallium-68 citrate has been successfully applied in the PET imaging of infections and inflammation in some centers; however further evaluation of the tracer in inflammation models is of great importance. METHODS: 68Ga-citrate prepared from [68Ga]GaCl3 (eluted form an SnO2 based 68Ge/68Ga generator) and sodium citrate at optimized conditions followed by quality control tests was injected to normal and turpentine-oil induced rats PET/CT imaging studies up to 290 min. RESULTS: 68Ga-citrate was prepared with acceptable radiochemical purity (>99 ITLC, >99% HPLC), specific activity (28-30 GBq/mM), chemical purity (Sn, Fe <0.3 ppm; Zn<0.2 ppm) in 15 min at 50°C. PET/CT imaging of the tracer demonstrated early detection of inflamed site in animal models in 60-80 min. CONCLUSION: This study demonstrated possible early detection of inflammation foci in vivo using 68Ga-citrate prepared using commercially available 68Ge/68Ga generators for PET imaging.
[Mh] Termos MeSH primário: Citratos/síntese química
Radioisótopos de Gálio/química
Germânio/química
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos/síntese química
Compostos de Estanho/química
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Ratos
Ratos Sprague-Dawley
Terebintina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Gallium Radioisotopes); 0 (Radiopharmaceuticals); 0 (Tin Compounds); 00072J7XWS (Germanium); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.2174/1874471009666160506130108


  5 / 1093 MEDLINE  
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[PMID]:26501409
[Au] Autor:Stankovic M; Pantic I; De Luka SR; Puskas N; Zaletel I; Milutinovic-Smiljanic S; Pantic S; Trbovich AM
[Ad] Endereço:Department of Pathophysiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
[Ti] Título:Quantification of structural changes in acute inflammation by fractal dimension, angular second moment and correlation.
[So] Source:J Microsc;261(3):277-84, 2016 Mar.
[Is] ISSN:1365-2818
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to examine alteration and possible application of fractal dimension, angular second moment, and correlation for quantification of structural changes in acutely inflamed tissue. Acute inflammation was induced by injection of turpentine oil into the right and left hind limb muscles of mice, whereas control animals received intramuscular saline injection. After 12 h, animals were anesthetised and treated muscles collected. The tissue was stained by hematoxylin and eosin, digital micrographs produced, enabling determination of fractal dimension of the cells, angular second moment and correlation of studied tissue. Histopathological analysis showed presence of inflammatory infiltrate and tissue damage in inflammatory group, whereas tissue structure in control group was preserved, devoid of inflammatory infiltrate. Fractal dimension of the cells, angular second moment and correlation of treated tissue in inflammatory group decreased in comparison to the control group. In this study, we were first to observe and report that fractal dimension of the cells, angular second moment, and correlation were reduced in acutely inflamed tissue, indicating loss of overall complexity of the cells in the tissue, the tissue uniformity and structure regularity. Fractal dimension, angular second moment and correlation could be useful methods for quantification of structural changes in acute inflammation.
[Mh] Termos MeSH primário: Processamento de Imagem Assistida por Computador/métodos
Inflamação/patologia
Microscopia/métodos
Músculo Esquelético/patologia
Músculo Esquelético/ultraestrutura
[Mh] Termos MeSH secundário: Animais
Fractais
Inflamação/induzido quimicamente
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Distribuição Aleatória
Terebintina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
8006-64-2 (Turpentine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE
[do] DOI:10.1111/jmi.12330


  6 / 1093 MEDLINE  
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[PMID]:26778394
[Au] Autor:Thayabaran M; Yasawardene SG
[Ad] Endereço:Department of Human Biology, Faculty of Health-Care Sciences, Eastern University of Sri Lanka.
[Ti] Título:Neuronal control of localized inflammation through expressed nicotinic acetylcholine receptors: a study carried out in mice.
[So] Source:Ceylon Med J;60(4):143-7, 2015 Dec.
[Is] ISSN:0009-0875
[Cp] País de publicação:Sri Lanka
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Although the local inflammatory reactions are known to be regulated through cholinergic anti-inflammatory pathways, the exact subtypes of nicotinic acetylcholine receptors involved in neuroimmune modulation are not well identified. OBJECTIVES: Immunohistochemical localisation of a1 subunit of nicotinic acetylcholine receptors (a1nAChR) in sites of localised inflammation induced by injecting turpentine to the hind limbs of Balb/C mice. METHODS: Localised inflammation and subsequent development of sterile abscesses was induced by injecting sterile turpentine subcutaneously into thighs of Balb/C mice. Sterile saline was used in the control.. Skin and muscle tissues of inflammatory sites were recovered from the animals after 48 hours and were stained with hematoxylin and eosin. Indirect immunohistochemistry was done using anti-a1nAChR as the primary antibody and biotinylated anti-rat IgG as the secondary antibody. Labeled streptavidin biotin (LSAB) technique was used with diaminobenzedene to detect the immunoreactivity (IR). Intensity of immunostaining was determined based upon a score of 0 - 3+ by qualitative computerised image analysis using FSX 100 Olympus microscope. RESULTS: H and E stained slides showed polymorphonuclear leukocytes (PNL) infiltration at the abscess sites while the saline injected control tissue sections did not show PNL infiltration. A 2+ immunoreactivity (IR) of a1nAChRs was visible at peripheral zones of sterile abscesses where PNL infiltrations were high while the central area with necrotic tissue did not show IR. A subcutaneous lymph node found within the inflammatory region expressed IR of a1nAChR in its capsular sinuses, subcapsular sinuses and trabecular regions. CONCLUSIONS: The findings suggest the possible role of controlling localised inflammatory response by parasympathetic cholinergic nerves through a1nAChRs of inflammation sites.
[Mh] Termos MeSH primário: Inflamação/metabolismo
Receptores Nicotínicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Membro Posterior
Imuno-Histoquímica
Inflamação/induzido quimicamente
Inflamação/imunologia
Injeções Subcutâneas
Irritantes/efeitos adversos
Camundongos
Camundongos Endogâmicos BALB C
Neutrófilos/imunologia
Terebintina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CHRNA1 protein, mouse); 0 (Irritants); 0 (Receptors, Nicotinic); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE
[do] DOI:10.4038/cmj.v60i4.8222


  7 / 1093 MEDLINE  
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[PMID]:26690600
[Au] Autor:Güzel A; Açikgöz M
[Ad] Endereço:Department of Pediatrics, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey. dracikgozm@gmail.com.
[Ti] Título:A lethal danger in the home: turpentine poisoning.
[So] Source:Turk J Pediatr;57(2):177-9, 2015 Mar-Apr.
[Is] ISSN:0041-4301
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Turpentine is an oleoresin obtained from various species of pine. In turpentine poisoning, various signs and symptoms of toxicity may develop, including hematuria, renal failure, loss of vision, chest pain, vomiting, severe coughing, gastroesophageal hemorrhage, hypotension, swelling of the throat and even death. We report a case of turpentine ingestion in a 9-year-old boy. The patient was admitted to our clinic with suspected intoxication after accidentally drinking from a glass that held a turpentine oil preparation used by his father for hair care. The patient displayed no significant signs and symptoms other than bradycardia and hypotension. Laboratory investigations revealed no abnormalities. The patient was hospitalized for close monitoring and observation. During a two-and-a-half-day observation period, hypotension was corrected with administration of dopamine and intravenous fluids. In this report, we wish to draw attention to the dangerous effects of plant-derived drugs.
[Mh] Termos MeSH primário: Bradicardia/induzido quimicamente
Hipotensão/induzido quimicamente
Solventes/envenenamento
Terebintina/envenenamento
[Mh] Termos MeSH secundário: Bradicardia/diagnóstico
Bradicardia/terapia
Criança
Preparações para Cabelo/envenenamento
Seres Humanos
Hipotensão/diagnóstico
Hipotensão/terapia
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hair Preparations); 0 (Solvents); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151222
[Lr] Data última revisão:
151222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE


  8 / 1093 MEDLINE  
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[PMID]:26690402
[Au] Autor:Tamaian R; Mot A; Silaghi-Dumitrescu R; Ionut I; Stana A; Oniga O; Nastasa C; Benedec D; Tiperciuc B
[Ad] Endereço:National Research and Development Institute for Cryogenic and Isotopic Technologies, 4th Uzinei Street, Râmnicu Vâlcea 240050, Romania. radu.tamaian@icsi.ro.
[Ti] Título:Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles.
[So] Source:Molecules;20(12):22188-201, 2015 Dec 11.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Lipophilicity, as one of the most important physicochemical parameters of bioactive molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles. The determination was carried out by reversed-phase thin-layer chromatography, using a binary isopropanol-water mobile phase. Chromatographically obtained lipophilicity parameters were correlated with calculated log P and log D and with some biological parameters, determined in order to evaluate the anti-inflammatory and antioxidant potential of the investigated compounds, by using principal component analysis (PCA). The PCA grouped the compounds based on the nature of their substituents (X, R and Y), indicating that their nature, electronic effects and molar volumes influence the lipophilicity parameters and their anti-inflammatory and antioxidant effects. Also, the results of the PCA analysis applied on all the experimental and computed parameters show that the best anti-inflammatory and antioxidant compounds were correlated with medium values of the lipophilicity parameters. On the other hand, the knowledge of the grouping patterns of the tested variables allows the reduction of the number of parameters, determined in order to establish the biological activity.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Antioxidantes/química
Semicarbazidas/química
Tiazóis/química
Tionas/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Interações Hidrofóbicas e Hidrofílicas
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Inflamação/metabolismo
Leucócitos/efeitos dos fármacos
Leucócitos/metabolismo
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Fagocitose/efeitos dos fármacos
Análise de Componente Principal
Ratos
Semicarbazidas/farmacologia
Relação Estrutura-Atividade
Tiazóis/farmacologia
Tionas/farmacologia
Terebintina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Semicarbazides); 0 (Thiazoles); 0 (Thiones); 31C4KY9ESH (Nitric Oxide); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE
[do] DOI:10.3390/molecules201219841


  9 / 1093 MEDLINE  
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[PMID]:26595963
[Au] Autor:Airapetova NS; Polikanova EB; Kulikova OV; Nitchenko OV; Sizyakova LA; Derevnina NA
[Ad] Endereço:Federal state budgetary institution 'Russian Research Centre for Medical Rehabilitation and Balneotherapy', Russian Ministry of Health, ul. Novy Arbat, 32, Moscow, Russian Federation, 121099.
[Ti] Título:[The combined application of yellow turpentine bathtubs and bronchodilators inhalations for the treatment of the patients presenting with chronic obstructive pulmonary disease].
[So] Source:Vopr Kurortol Fizioter Lech Fiz Kult;92(4):13-17, 2015 Jul-Aug.
[Is] ISSN:0042-8787
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This paper was designed to report the results of comparative clinical and functional studies involving 89 patients who presented with moderately severe chronic obstructive pulmonary disease and were given the combined treatment with yellow turpentine bathtubs and bronchodilators inhalations with the use of a nebulizer. The patients comprising group 1 (n=29) were treated with yellow turpentine bathtubs and bronchodilators inhalations, those making up group 2 (n=30) received monotherapy with yellow turpentine bathtubs alone, and the patients included in group 3 (n=3) served as controls treated with the use of therapeutic physical exercises and symptomatic medications analogous to those given to the patients of the two former groups. The results of the study give evidence of the advantages of the rehabilitative complex including yellow turpentine bathtubs and atrovent inhalations over two alternative therapeutic modalities attributable to its pronounced anti-inflammatory and immune-corrective activity that resulted in the generalized improvement of bronchial patency, reduction of lung hypertension, and enhancement of physical tolerance; taken together, these effects ensured the best clinical results.
[Mh] Termos MeSH primário: Balneologia
Broncodilatadores/uso terapêutico
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
Terebintina/uso terapêutico
[Mh] Termos MeSH secundário: Administração por Inalação
Broncodilatadores/administração & dosagem
Terapia Combinada
Seres Humanos
Doença Pulmonar Obstrutiva Crônica/terapia
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 8006-64-2 (Turpentine)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151125
[St] Status:MEDLINE
[do] DOI:10.17116/kurort2015413-17


  10 / 1093 MEDLINE  
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[PMID]:26220318
[Au] Autor:Marini D; Pippia J; Colditz IG; Hinch G; Petherick JC; Lee C
[Ad] Endereço:CSIRO, FD McMaster Laboratory, New England Highway, Armidale, New South Wales, Australia. danila.marini@csiro.au.
[Ti] Título:Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
[So] Source:Aust Vet J;93(8):265-70, 2015 Aug.
[Is] ISSN:1751-0813
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the efficacy and bioavailability of non-steroidal anti-inflammatory drugs (NSAIDs) when administered orally to sheep. DESIGN: Randomised experimental design with four treatment groups: three NSAID groups and one control group (n = 10/group). The study animals were 40 18-month-old Merino ewes with an average weight of 31.4 ± 0.5 kg. METHODS: Treatment was given orally at 24 h intervals for 6 days at dose rates expected to achieve therapeutic levels in sheep: carprofen (8.0 mg/kg), ketoprofen (8.0 mg/kg) and flunixin (4.0 mg/kg). Oil of turpentine (0.1 mL) was injected into a forelimb of each sheep to induce inflammation and pain; responses (force plate pressure, skin temperature, limb circumference, haematology and plasma cortisol) were measured at 0, 3, 6, 9, 12, 24, 36, 48, 72 and 96 h post-injection. NSAID concentrations were determined by ultra-high-pressure liquid chromatography. RESULTS: The NSAIDs were detectable in ovine plasma 2 h after oral administration, with average concentrations of 4.5-8.4 µg/mL for ketoprofen, 2.6-4.1 µg/mL for flunixin and 30-80 µg/mL for carprofen. NSAID concentrations dropped 24 h after administration. Pain response to an oil of turpentine injection was assessed using the measures applied but no effect of the NSAIDs was observed. Although this pain model has been previously validated, the responses observed in this study differed from those in the previous study. CONCLUSIONS AND CLINICAL RELEVANCE: The three NSAIDs reached inferred therapeutic concentrations in blood at 2 h after oral administration. The oil of turpentine lameness model may need further validation.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Anti-Inflamatórios não Esteroides/farmacocinética
Coxeadura Animal/tratamento farmacológico
Dor/veterinária
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Inflamatórios não Esteroides/sangue
Disponibilidade Biológica
Carbazóis/administração & dosagem
Carbazóis/sangue
Carbazóis/farmacocinética
Clonixino/administração & dosagem
Clonixino/análogos & derivados
Clonixino/sangue
Clonixino/farmacocinética
Estudos de Coortes
Modelos Animais de Doenças
Feminino
Membro Anterior
Hidrocortisona/sangue
Irritantes/efeitos adversos
Cetoprofeno/administração & dosagem
Cetoprofeno/sangue
Cetoprofeno/farmacocinética
Coxeadura Animal/induzido quimicamente
Coxeadura Animal/complicações
Dor/tratamento farmacológico
Ovinos
Terebintina/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Carbazoles); 0 (Irritants); 356IB1O400 (flunixin); 8006-64-2 (Turpentine); 90Y4QC304K (Ketoprofen); FFL0D546HO (carprofen); V7DXN0M42R (Clonixin); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150729
[Lr] Data última revisão:
150729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150730
[St] Status:MEDLINE
[do] DOI:10.1111/avj.12351



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