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[PMID]:29241324
[Au] Autor:Famurewa AC; Nwankwo OE; Folawiyo AM; Igwe EC; Epete MA; Ufebe OG
[Ad] Endereço:Department of Medical Biochemistry, Federal University Ndufu-Alike Ikwo Abakaliki, Ebonyi State, Nigeria.
[Ti] Título:Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation.
[So] Source:Acta Sci Pol Technol Aliment;16(4):451-460, 2017 Oct-Dec.
[Is] ISSN:1898-9594
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The literature reports that the health benefits of vegetable oil can be deteriorated by repeated heating, which leads to lipid oxidation and the formation of free radicals. Virgin coconut oil (VCO) is emerging as a functional food oil and its health benefits are attributed to its potent polyphenolic compounds. We investigated the beneficial effect of VCO supplementation on lipid profile, liver and kidney markers in rats fed repeatedly heated palm kernel oil (HPO). METHODS: Rats were divided into four groups (n = 5). The control group rats were fed with   a normal diet; group 2 rats were fed a 10% VCO supplemented diet; group 3 administered 10 ml HPO/kg b.w. orally; group 4 were fed 10% VCO + 10 ml HPO/kg for 28 days. Subsequently, serum markers of liver damage (ALT, AST, ALP and albumin), kidney damage (urea, creatinine and uric acid), lipid profile and lipid ratios as cardiovascular risk indices were evaluated. RESULTS: HPO induced a significant increase in serum markers of liver and kidney damage as well as con- comitant lipid abnormalities and a marked reduction in serum HDL-C. The lipid ratios evaluated for atherogenic and coronary risk indices in rats administered HPO only were remarkably higher than control. It was observed that VCO supplementation attenuated the biochemical alterations, including the indices of cardiovascular risks. CONCLUSIONS: VCO supplementation demonstrates beneficial health effects against HPO-induced biochemical alterations in rats. VCO may serve to modulate the adverse effects associated with consumption of repeatedly heated palm kernel oil.
[Mh] Termos MeSH primário: Aterosclerose/tratamento farmacológico
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Óleo de Coco/administração & dosagem
Hiperlipidemias/tratamento farmacológico
Nefropatias/tratamento farmacológico
Óleos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Aterosclerose/induzido quimicamente
Temperatura Alta
Hiperlipidemias/induzido quimicamente
Nefropatias/induzido quimicamente
Óleos Vegetais/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 0 (palm kernel oil); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.17306/J.AFS.0513


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[PMID]:28704429
[Au] Autor:Newell-Fugate AE; Lenz K; Skenandore C; Nowak RA; White BA; Braundmeier-Fleming A
[Ad] Endereço:Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, United States of America.
[Ti] Título:Effects of coconut oil on glycemia, inflammation, and urogenital microbial parameters in female Ossabaw mini-pigs.
[So] Source:PLoS One;12(7):e0179542, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Forty percent of American women are obese and at risk for type II diabetes, impaired immune function, and altered microbiome diversity, thus impacting overall health. We investigated whether obesity induced by an excess calorie, high fat diet containing hydrogenated fats, fructose, and coconut oil (HFD) altered glucose homeostasis, peripheral immunity, and urogenital microbial dynamics. We hypothesized that HFD would cause hyperglycemia, increase peripheral inflammation, and alter urogenital microbiota to favor bacterial taxonomy associated with inflammation. We utilized female Ossabaw mini-pigs to model a 'thrifty' metabolic phenotype associated with increased white adipose tissue mass. Pigs were fed HFD (~4570 kcal/pig/day) or lean (~2000 kcal/pig/day) diet for a total of 9 estrous cycles (~6 months). To determine the effect of cycle stage on cytokines and the microbiome, animals had samples collected during cycles 7 and 9 on certain days of the cycle: D1, 4, 8, 12, 16, 18. Vaginal swabs or cervical flushes assessed urogenital microbiota. Systemic fatty acids, insulin, glucose, and cytokines were analyzed. Pig weights and morphometric measurements were taken weekly. Obese pigs had increased body weight, length, heart and belly girth but similar glucose concentrations. Obese pigs had decreased cytokine levels (IL-1ß, TNF-α, IL-4, IL-10), arachidonic acid and plasma insulin, but increased levels of vaccenic acid. Obese pigs had greater urogenital bacterial diversity, including several taxa known for anti-inflammatory properties. Overall, induction of obesity did not induce inflammation but shifted the microbial communities within the urogenital tract to an anti-inflammatory phenotype. We postulate that the coconut oil in the HFD oil may have supported normal glucose homeostasis and modulated the immune response, possibly through regulation of microbial community dynamics and fatty acid metabolism. This animal model holds promise for the study of how different types of obesity and high fat diets may affect metabolism, immune phenotype, and microbial dynamics.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Citocinas/metabolismo
Inflamação/imunologia
Obesidade/complicações
Óleos Vegetais/administração & dosagem
Sistema Urogenital/microbiologia
[Mh] Termos MeSH secundário: Animais
Óleo de Coco
Dieta Hiperlipídica
Modelos Animais de Doenças
Feminino
Seres Humanos
Microbiota
Obesidade/induzido quimicamente
Obesidade/imunologia
Óleos Vegetais/efeitos adversos
Suínos
Porco Miniatura
Sistema Urogenital/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Cytokines); 0 (Plant Oils); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179542


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[PMID]:28617858
[Au] Autor:Prasadani WC; Senanayake CM; Jayathilaka N; Ekanayake S; Seneviratne KN
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.
[Ti] Título:Effect of three edible oils on the intestinal absorption of caffeic acid: An in vivo and in vitro study.
[So] Source:PLoS One;12(6):e0179292, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Polyphenolic antioxidants are mainly absorbed through passive paracellular permeation regulated by tight junctions. Some fatty acids are known to modulate tight junctions. Fatty acids resulting from the digestion of edible oils may improve the absorption of polyphenolic antioxidants. Therefore, we explored the effect of three edible oils on the intestinal absorption of caffeic acid. Rats were fed with soybean oil and caffeic acid dissolved in distilled water. Caffeic acid contents in the plasma collected up to 1 hr were quantified. The experiment was repeated with coconut oil and olive oil. Component fatty acids of the oils were individually tested in vitro for their effect on permeability of caffeic acid using Caco-2 cell monolayers. Highest absorption of caffeic acid was observed in animals fed with coconut oil. In vitro transport percentages of caffeic acid in 2.5 mmol/L solutions of fatty acids were 22.01±0.12 (lauric), 15.30 ± 0.25 (myristic acid), 13.59 ± 0.35 (linoleic acid), 3.70 ± 0.09 (oleic acid) and 0.10-2.0 (all other fatty acids). Lauric acid and myristic acid are the two major fatty acids present in coconut oil. Therefore, these fatty acids may contribute to the higher absorption of caffeic acid in the presence of coconut oil.
[Mh] Termos MeSH primário: Ácidos Cafeicos
Absorção Intestinal/efeitos dos fármacos
Óleos Vegetais/farmacologia
Óleo de Soja/farmacologia
[Mh] Termos MeSH secundário: Animais
Transporte Biológico Ativo/efeitos dos fármacos
Células CACO-2
Ácidos Cafeicos/farmacocinética
Ácidos Cafeicos/farmacologia
Óleo de Coco
Ácidos Graxos/farmacocinética
Ácidos Graxos/farmacologia
Seres Humanos
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Fatty Acids); 0 (Plant Oils); 8001-22-7 (Soybean Oil); Q9L0O73W7L (Coconut Oil); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179292


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[PMID]:28564614
[Au] Autor:Kim S; Jang JE; Kim J; Lee YI; Lee DW; Song SY; Lee JH
[Ad] Endereço:Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
[Ti] Título:Enhanced barrier functions and anti-inflammatory effect of cultured coconut extract on human skin.
[So] Source:Food Chem Toxicol;106(Pt A):367-375, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin. To evaluate the anti-inflammatory properties of CCE, the expression of inflammatory markers was analyzed after ultraviolet B (UVB) irradiation. The CCE-treated group showed increased expression of cornified cell envelope components, which contribute to protective barrier functions of the stratum corneum. Further, the expression of inflammatory markers was lower in the CCE-treated group after exposure to UVB radiation. These results suggest an anti-inflammatory effect of CCE against UVB irradiation-induced inflammation. Additionally, the CCE-treated group showed increased collagen and hyaluronan synthase-3 expression. In our study, CCE showed a barrier-enhancing effect and anti-inflammatory properties against ex vivo UVB irradiation-induced inflammation. The promising effect of CCE may be attributed to its high levels of polyphenols and fatty acid components.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Cocos/química
Extratos Vegetais/farmacologia
Óleos Vegetais/farmacologia
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Anti-Inflamatórios/análise
Óleo de Coco
Colágeno/metabolismo
Seres Humanos
Meia-Idade
Extratos Vegetais/análise
Óleos Vegetais/análise
Polifenóis/análise
Polifenóis/farmacologia
Pele/metabolismo
Pele/efeitos da radiação
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Plant Oils); 0 (Polyphenols); 9007-34-5 (Collagen); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


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[PMID]:28405165
[Au] Autor:Musa SH; Basri M; Fard Masoumi HR; Shamsudin N; Salim N
[Ad] Endereço:Department of Chemistry, Faculty of Science.
[Ti] Título:Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action.
[So] Source:Int J Nanomedicine;12:2427-2441, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Psoriasis is a chronic autoimmune disease that cannot be cured. It can however be controlled by various forms of treatment, including topical, systemic agents, and phototherapy. Topical treatment is the first-line treatment and favored by most physicians, as this form of therapy has more patient compliance. Introducing a nanoemulsion for transporting cyclosporine as an anti-inflammatory drug to an itchy site of skin disease would enhance the effectiveness of topical treatment for psoriasis. The addition of nutmeg and virgin coconut-oil mixture, with their unique properties, could improve cyclosporine loading and solubility. A high-shear homogenizer was used in formulating a cyclosporine-loaded nanoemulsion. A D-optimal mixture experimental design was used in the optimization of nanoemulsion compositions, in order to understand the relationships behind the effect of independent variables (oil, surfactant, xanthan gum, and water content) on physicochemical response (particle size and polydispersity index) and rheological response (viscosity and -value). Investigation of these variables suggests two optimized formulations with specific oil (15% and 20%), surfactant (15%), xanthan gum (0.75%), and water content (67.55% and 62.55%), which possessed intended responses and good stability against separation over 3 months' storage at different temperatures. Optimized nanoemulsions of pH 4.5 were further studied with all types of stability analysis: physical stability, coalescence-rate analysis, Ostwald ripening, and freeze-thaw cycles. In vitro release proved the efficacy of nanosize emulsions in carrying cyclosporine across rat skin and a synthetic membrane that best fit the Korsmeyer-Peppas kinetic model. In vivo skin analysis towards healthy volunteers showed a significant improvement in the stratum corneum in skin hydration.
[Mh] Termos MeSH primário: Ciclosporina/administração & dosagem
Fármacos Dermatológicos/administração & dosagem
Emulsões/química
Nanoestruturas/química
Psoríase/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Animais
Óleo de Coco
Ciclosporina/farmacologia
Fármacos Dermatológicos/farmacologia
Difusão
Avaliação Pré-Clínica de Medicamentos/métodos
Emulsões/farmacologia
Feminino
Seres Humanos
Myristica fragrans
Nanoestruturas/administração & dosagem
Tamanho da Partícula
Óleos Vegetais/administração & dosagem
Óleos Vegetais/química
Polissacarídeos Bacterianos/química
Ratos
Pele/metabolismo
Solubilidade
Tensoativos/química
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dermatologic Agents); 0 (Emulsions); 0 (Plant Oils); 0 (Polysaccharides, Bacterial); 0 (Surface-Active Agents); 83HN0GTJ6D (Cyclosporine); Q9L0O73W7L (Coconut Oil); TTV12P4NEE (xanthan gum)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S125302


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[PMID]:28277823
[Au] Autor:Harris M; Hutchins A; Fryda L
[Ad] Endereço:Department of Health Sciences, University of Colorado Colorado Springs , Colorado Springs, Colorado, USA .
[Ti] Título:The Impact of Virgin Coconut Oil and High-Oleic Safflower Oil on Body Composition, Lipids, and Inflammatory Markers in Postmenopausal Women.
[So] Source:J Med Food;20(4):345-351, 2017 Apr.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This randomized crossover study compared the impact of virgin coconut oil (VCO) to safflower oil (SO) on body composition and cardiovascular risk factors. Twelve postmenopausal women (58.8 ± 3.7 year) consumed 30 mL VCO or SO for 28 days, with a 28-day washout. Anthropometrics included body weight and hip and waist circumference. Fat percent for total body, android and gynoid, fat mass, and lean mass were measured using dual-energy X-ray absorptiometry. Women maintained their typical diet recording 28 days of food records during the study. Results were analyzed with SPSS v24 with significance at P ≤ .05. Comparisons are reported as paired t-test since no intervention sequence effect was observed. VCO significantly raised total cholesterol, TC (+18.2 ± 22.8 mg/dL), low-density lipoprotein (+13.5 ± 16.0 mg/dL), and high-density lipoprotein, HDL (+6.6 ± 7.5 mg/dL). SO did not significantly change lipid values. TC and HDL were significantly different between test oils. The TC/HDL ratio change showed a neutral effect of both VCO and SO. One person had adverse reactions to VCO and increased inflammation. VCO decreased IL-1ß for each person who had a detected sample. The impact of VCO and SO on other cytokines varied on an individual basis. This was the first study evaluating the impact of VCO on body composition in Caucasian postmenopausal women living in the United States. Results are suggestive that individuals wishing to use coconut oil in their diets can do so safely, but more studies need to be conducted with larger sample sizes, diverse populations, and more specific clinical markers such as particle size.
[Mh] Termos MeSH primário: Composição Corporal
Inflamação/tratamento farmacológico
Lipídeos/sangue
Óleos Vegetais/administração & dosagem
Pós-Menopausa
Óleo de Açafrão/administração & dosagem
[Mh] Termos MeSH secundário: Peso Corporal
Colesterol/sangue
Óleo de Coco
Estudos Cross-Over
Dieta
Gorduras na Dieta/metabolismo
Feminino
Seres Humanos
Lipoproteínas HDL/sangue
Lipoproteínas LDL/sangue
Meia-Idade
Triglicerídeos/sangue
Circunferência da Cintura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Lipids); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL); 0 (Plant Oils); 0 (Triglycerides); 8001-23-8 (Safflower Oil); 97C5T2UQ7J (Cholesterol); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0114


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[PMID]:28130913
[Au] Autor:Jonnada M; El Rassi GD; El Rassi Z
[Ad] Endereço:Department of Chemistry, Oklahoma State University, Stillwater, OK, USA.
[Ti] Título:Selective precolumn derivatization of fatty acids with the fluorescent tag 6-aminoquinoline and their determination in some food samples by reversed-phase chromatography.
[So] Source:Electrophoresis;38(12):1592-1601, 2017 06.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Fatty acids (FAs) have been selectively derivatized with a fluorescent tag, 6-aminoquinoline (6AQ), which yielded fluorescent FA-6AQ derivatives that have excitation (λ = 270 nm) and emission (λ = 495 nm) wavelengths that are farther apart. This precolumn derivatization is characterized by its simplicity occurring at room temperature between the carboxylic acid group of the FA and the amino group of 6AQ in the presence of a nonaqueous soluble carbodiimide coupling agent such as the N,N´-dicyclohexylcarbodiimide. The FAs extracts are readily derivatized in chloroform and can be analyzed without any further sample cleanup that minimizes sample loss. The FA-6AQ derivatives derived from standard FAs as well as from extracted FAs from food samples were separated by reversed phase chromatography on a homemade naphthyl methacrylate monolithic (NMM) column and C4 silica-based column. While the NMM column provided excellent separation for saturated FA-6AQ derivatives, the C4 silica column was able to separate simultaneously saturated and unsaturated FA-6AQ derivatives. The MNN column permitted the analysis and quantitation of the saturated FA-6AQ derivatives extracted from coconut oil. The C4 column provided the selectivity needed to analyze and quantify saturated and unsaturated derivatized with 6AQ and extracted from meat. The limits of detection and quantitation were 5 and 20 nM, respectively, with a linear dynamic range extending from 20 nM to 40 µM. The 40 µM upper limit was due to the limited solubility of the FA-6AQ derivatives in the diluting mobile phase, which is the initial mobile phase used in gradient runs.
[Mh] Termos MeSH primário: Aminoquinolinas/química
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia de Fase Reversa/métodos
Ácidos Graxos/química
Corantes Fluorescentes/química
Análise de Alimentos/métodos
[Mh] Termos MeSH secundário: Óleo de Coco
Ácido Mirístico/química
Ácido Oleico/química
Ácido Palmítico/química
Óleos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoquinolines); 0 (Fatty Acids); 0 (Fluorescent Dyes); 0 (Plant Oils); 0I3V7S25AW (Myristic Acid); 2UMI9U37CP (Oleic Acid); 2V16EO95H1 (Palmitic Acid); 580-15-4 (6-aminoquinoline); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600544


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[PMID]:28129764
[Au] Autor:Gunasekaran R; Shaker MR; Mohd-Zin SW; Abdullah A; Ahmad-Annuar A; Abdul-Aziz NM
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Maternal intake of dietary virgin coconut oil modifies essential fatty acids and causes low body weight and spiky fur in mice.
[So] Source:BMC Complement Altern Med;17(1):79, 2017 Jan 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coconut oil is commonly used as herbal medicine worldwide. There is limited information regarding its effects on the developing embryo and infant growth. METHODS: We investigated the effect of virgin coconut oil post-natally and until 6 weeks old in mice (age of maturity). Females were fed with either standard, virgin olive oil or virgin coconut oil diets 1 month prior to copulation, during gestation and continued until weaning of pups. Subsequently, groups of pups borne of the respective diets were continuously fed the same diet as its mother from weaning until 6 weeks old. Profiles of the standard and coconut oil diets were analysed by gas chromatography flame ionization detector (GCFID). RESULTS: Analysis of the mean of the total weight gained/ loss over 6 weeks revealed that in the first 3 weeks, pups whose mothers were fed virgin coconut oil and virgin olive oil have a significantly lower body weight than that of standard diet pups. At 6 weeks of age, only virgin coconut oil fed pups exhibited significantly lower body weight. We report that virgin coconut oil modifies the fatty acid profiles of the standard diet by inducing high levels of medium chain fatty acids with low levels of essential fatty acids. Furthermore, pups borne by females fed with virgin coconut oil developed spiky fur. CONCLUSION: Our study has demonstrated that virgin coconut oil could affect infant growth and appearance via maternal intake; we suggest the use of virgin coconut oil as herbal medicine to be treated with caution.
[Mh] Termos MeSH primário: Cocos/química
Dieta
Ácidos Graxos Essenciais/sangue
Cabelo/efeitos dos fármacos
Fenômenos Fisiológicos da Nutrição Materna
Óleos Vegetais/efeitos adversos
Ganho de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Óleo de Coco
Gorduras Insaturadas na Dieta/efeitos adversos
Gorduras Insaturadas na Dieta/sangue
Ácidos Graxos/análise
Comportamento Alimentar
Feminino
Camundongos Endogâmicos
Nozes/química
Óleos Vegetais/química
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats, Unsaturated); 0 (Fatty Acids); 0 (Fatty Acids, Essential); 0 (Plant Oils); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1600-z


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[PMID]:28126345
[Au] Autor:Clifford AM; Bury NR; Schultz AG; Ede JD; Goss BL; Goss GG
[Ad] Endereço:Bamfield Marine Sciences Centre, Bamfield, BC, Canada; Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
[Ti] Título:Regulation of plasma glucose and sulfate excretion in Pacific hagfish, Eptatretus stoutii is not mediated by 11-deoxycortisol.
[So] Source:Gen Comp Endocrinol;247:107-115, 2017 Jun 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The goal of this study was to identify whether Pacific hagfish (Eptatretus stoutii) possess glucocorticoid and mineralocorticoid responses and to examine the potential role(s) of four key steroids in these responses. Pacific hagfish were injected with varying amounts of cortisol, corticosterone or 11-deoxycorticosterone (DOC) using coconut oil implants and plasma glucose and gill total-ATPase activity were monitored as indices of glucocorticoid and mineralocorticoid responses. Furthermore, we also monitored plasma glucose and 11-deoxycortisol (11-DOC) levels following exhaustive stress (30 min of agitation) or following repeated infusion with SO . There were no changes in gill total-ATPase following implantation with any steroid, with only very small statistical increases in plasma glucose noted in hagfish implanted with either DOC (at 20 and 200mgkg at 7 and 4days post-injection, respectively) or corticosterone (at 100mgkg at 7days post-injection). Following exhaustive stress, hagfish displayed a large and sustained increase in plasma glucose. Repeated infusion of SO into hagfish caused increases in both plasma glucose levels and SO excretion rate suggesting a regulated glucocorticoid and mineralocorticoid response. However, animals under either condition did not show any significant increases in plasma 11-DOC concentrations. Our results suggest that while there are active glucocorticoid and mineralocorticoid responses in hagfish, 11-DOC does not appear to be involved and the identity and primary function of the steroid in hagfish remains to be elucidated.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Cortodoxona/metabolismo
Feiticeiras (Peixe)/fisiologia
Sulfatos/metabolismo
[Mh] Termos MeSH secundário: Animais
Vias Biossintéticas
Óleo de Coco
Corticosterona/biossíntese
Óleos Vegetais/farmacologia
Estresse Fisiológico
Sulfatos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Plant Oils); 0 (Sulfates); Q9L0O73W7L (Coconut Oil); W980KJ009P (Corticosterone); WDT5SLP0HQ (Cortodoxone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


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[PMID]:28118770
[Au] Autor:Rahim NS; Lim SM; Mani V; Abdul Majeed AB; Ramasamy K
[Ad] Endereço:a Collaborative Drug Discovery Research (CDDR) Group , Pharmaceutical and Life Sciences Community of Research, Universiti Teknologi MARA (UiTM) , Shah Alam , Selangor Darul Ehsan , Malaysia.
[Ti] Título:Enhanced memory in Wistar rats by virgin coconut oil is associated with increased antioxidative, cholinergic activities and reduced oxidative stress.
[So] Source:Pharm Biol;55(1):825-832, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE: Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS: Thirty male Wistar rats (7-8 weeks old) were randomly assigned to five groups (n = six per group). Treatment groups were administered with 1, 5 and 10 g/kg VCO for 31 days by oral gavages. The cognitive function of treated-rats were assessed using the Morris Water Maze Test. Brains were removed, homogenized and subjected to biochemical analyses of acetylcholine (ACh) and acetylcholinesterase (AChE), antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx) and glutathione reductase (GRx)], lipid peroxidase [malondialdehyde (MDA)] as well as nitric oxide (NO). α-Tocopherol (αT; 150 mg/kg) was also included for comparison purposes. RESULTS: VCO-fed Wistar rats exhibited significant (p < 0.05) improvement of cognitive functions [reduced escape latency (≥ 1.8 s), reduced escape distance (≥ 0.3 m) and increased total time spent on platform (≥ 1 s)]. The findings were accompanied by elevation of ACh (15%), SOD (8%), CAT (≥ 54%), GSH (≥ 20%) and GPx (≥ 12%) and reduction of AChE (≥17%), MDA (> 33%) and NO (≥ 34%). Overall, memory improvement by VCO was comparable to αT. DISCUSSION AND CONCLUSION: VCO has the potential to be used as a memory enhancer, the effect of which was mediated, at least in part, through enhanced cholinergic activity, increased antioxidants level and reduced oxidative stress.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Colinérgicos/farmacologia
Memória/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolina/análise
Animais
Óleo de Coco
Cognição/efeitos dos fármacos
Masculino
Atividade Motora/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholinergic Agents); 0 (Plant Oils); N9YNS0M02X (Acetylcholine); Q9L0O73W7L (Coconut Oil)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1280688



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