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[PMID]:29278027
[Au] Autor:Madhavadas S; Subramanian S; Kutty BM
[Ad] Endereço:1 Department of Neurochemistry, National Institute of Mental Health and Neurosciences , Bangalore, India.
[Ti] Título:Environmental enrichment improved cognitive deficits more in peri-adolescent than in adult rats after postnatal monosodium glutamate treatment.
[So] Source:Physiol Int;104(4):271-290, 2017 Dec 01.
[Is] ISSN:2498-602X
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Exposure to enriched environment (EE) is known to promote sensory, cognitive, and motor stimulation with intensified levels of novelty and complexity. In this study, we investigated the positive regulatory effect of short-term exposure to EE on establishing functional recovery in monosodium glutamate (MSG)-induced obese rats. Unless treated, MSG rats exhibited peripheral insulin resistance, cognitive deficits, and a reduction in the total hippocampal volume with decreased neuron count in the DG, CA3, and CA1 subfields. These MSG rats were exposed to short-term EE for 15 days for a period of 6 h/day, beginning either at 45 or at 75 days of age. EE exposure has improved insulin sensitivity, yielded a significant increase in total hippocampal volume along with increase in neuron number in the CA1 subfield of the hippocampus in both age groups. However, as assessed by radial arm maze task, which relies upon the positive reinforcement to test spatial memory, and the Barnes maze task, which utilizes an aversive learning strategy, a complete recovery of cognitive function could be achieved in 2-month-old rats only and not among 3-month-old rats, thus highlighting the importance of critical window period for EE interventions in restoring the memory functions. These results suggest the therapeutic potential of EE paradigm in prevention of cognitive disorders.
[Mh] Termos MeSH primário: Transtornos Cognitivos/prevenção & controle
Transtornos Cognitivos/fisiopatologia
Cognição
Meio Ambiente
Hipocampo/fisiopatologia
Estimulação Física/métodos
Glutamato de Sódio
[Mh] Termos MeSH secundário: Animais
Transtornos Cognitivos/induzido quimicamente
Hipocampo/efeitos dos fármacos
Hipocampo/patologia
Masculino
Ratos
Ratos Sprague-Dawley
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1556/2060.104.2017.4.7


  2 / 1696 MEDLINE  
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[PMID]:29241319
[Au] Autor:Chen H; Huang J; Shi X; Li Y; Liu Y
[Ad] Endereço:School of Food and Biological Engineering, Shaanxi University of Science and Technology Xi?an,China.
[Ti] Título:Effects of six substances on the growth and freeze-drying of Lactobacillus delbrueckii subsp. bulgaricus.
[So] Source:Acta Sci Pol Technol Aliment;16(4):403-412, 2017 Oct-Dec.
[Is] ISSN:1898-9594
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The efficacy of Lactobacillus delbrueckii subsp. bulgaricus as starter cultures for the dairy industry depends largely on the number of viable and active cells. Freeze-drying is the most convenient and successful method to preserve the bacterial cells. However, not all strains survived during freeze-drying. METHODS: The effects of six substances including NaCl, sorbitol, mannitol, mannose, sodium glutamate, betaine added to the MRS medium on the growth and freeze-drying survival rate and viable counts of Lb. delbrueckii subsp. bulgaricus were studied through a single-factor test and Plackett-Burman design. Subsequently, the optimum freeze-drying conditions of Lb. delbrueckii subsp. bulgaricus were determined. RESULTS: Lb. delbrueckii subsp. bulgaricus survival rates were up to the maximum of 42.7%, 45.4%, 23.6%, while the concentrations of NaCl, sorbitol, sodium glutamate were 0.6%, 0.15%, 0.09%, respectively. In the optimum concentration, the viable counts in broth is 6.1, 6.9, 5.13 (×108 CFU/mL), respectively; the viable counts in freeze-drying power are 3.09, 5.2, 2.7 (×1010 CFU/g), respectively. CONCLUSIONS: Three antifreeze factors including NaCl, sorbitol, sodium glutamate have a positive effect on the growth and freeze-drying of Lb. delbrueckii subsp. bulgaricus. The results are beneficial for developing Lb. delbrueckii subsp. bulgaricus.
[Mh] Termos MeSH primário: Crioprotetores/farmacologia
Aditivos Alimentares/farmacologia
Liofilização
Lactobacillus delbrueckii
[Mh] Termos MeSH secundário: Betaína/farmacologia
Lactobacillus delbrueckii/efeitos dos fármacos
Lactobacillus delbrueckii/crescimento & desenvolvimento
Manitol/farmacologia
Viabilidade Microbiana
Cloreto de Sódio/farmacologia
Glutamato de Sódio/farmacologia
Sorbitol/farmacologia
Iogurte/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryoprotective Agents); 0 (Food Additives); 3OWL53L36A (Mannitol); 3SCV180C9W (Betaine); 451W47IQ8X (Sodium Chloride); 506T60A25R (Sorbitol); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.17306/J.AFS.0512


  3 / 1696 MEDLINE  
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Boschero, Antonio Carlos
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[PMID]:28866102
[Au] Autor:Soares GM; Cantelli KR; Balbo SL; Ribeiro RA; Alegre-Maller ACP; Barbosa-Sampaio HC; Boschero AC; Araújo ACF; Bonfleur ML
[Ad] Endereço:Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, Brazil.
[Ti] Título:Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway.
[So] Source:Life Sci;188:68-75, 2017 Nov 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Hypothalamic obesity is a severe condition without any effective therapy. Bariatric operations appear as an alternative treatment, but the effects of this procedure are controversial. We, herein, investigated the effects of duodeno-jejunal bypass (DJB) surgery upon the lipid profile and expression of genes and proteins, involved in the regulation of hepatic lipid metabolism, in hypothalamic obese (HyO) rats. METHODS: During the first 5days of life, male newborn Wistar rats received subcutaneous injections of monosodium glutamate [4g/kg body weight, HyO group] or saline (control, CTL group). At 90days of life, HyO rats were randomly submitted to DJB (HyO DJB) or Sham-operations (HyO Sham group). Six months after DJB, adiposity, hepatic steatosis and lipid metabolism were verified. KEY FINDINGS: HyO Sham rats were obese, hyperinsulinemic, insulin resistant and dyslipidemic. These rats had higher liver contents of trygliceride (TG) and presented disorganization of the hepatocyte structures, in association with higher hepatic contents of acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), and stearoyl-CoA desaturase-1 mRNAs and protein. DJB surgery normalized insulinemia, insulin resistance, and dyslipidemia in HyO rats. TG content in the liver and the hepatic microscopic structures were also normalized in HyO DJB rats, while the expressions of ACC and FASN proteins were decreased in the liver of these rodents. SIGNIFICANCE: The DJB-induced amelioration in hepatic steatosis manifested as a late effect in HyO rats, and was partly associated with a downregulation in hepatic de novo lipogenesis processes, indicating that DJB protects against liver steatosis in hypothalamic obesity.
[Mh] Termos MeSH primário: Fígado Gorduroso/metabolismo
Fígado Gorduroso/cirurgia
Derivação Gástrica
Metabolismo dos Lipídeos
Obesidade/metabolismo
Obesidade/cirurgia
[Mh] Termos MeSH secundário: Acetil-CoA Carboxilase/metabolismo
Animais
Ácido Graxo Sintases/metabolismo
Fígado Gorduroso/patologia
Masculino
Obesidade/induzido quimicamente
Obesidade/patologia
Ratos
Glutamato de Sódio
Estearoil-CoA Dessaturase/metabolismo
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triglycerides); EC 1.14.19.1 (Stearoyl-CoA Desaturase); EC 2.3.1.85 (Fatty Acid Synthases); EC 6.4.1.2 (Acetyl-CoA Carboxylase); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


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[PMID]:28847084
[Au] Autor:Yiin CL; Quitain AT; Yusup S; Uemura Y; Sasaki M; Kida T
[Ad] Endereço:Biomass Processing Cluster, Center of Biofuel and Biochemical Research, Chemical Engineering Department, Mission Oriented Research (Green Technology), Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 32610 Tronoh, Perak, Malaysia.
[Ti] Título:Choline chloride (ChCl) and monosodium glutamate (MSG)-based green solvents from optimized cactus malic acid for biomass delignification.
[So] Source:Bioresour Technol;244(Pt 1):941-948, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work aimed to develop an efficient microwave-hydrothermal (MH) extraction of malic acid from abundant natural cactus as hydrogen bond donor (HBD) whereby the concentration was optimized using response surface methodology. The ideal process conditions were found to be at a solvent-to-feed ratio of 0.008, 120°C and 20min with 1.0g of oxidant, H O . Next generation environment-friendly solvents, low transition temperature mixtures (LTTMs) were synthesized from cactus malic acid with choline chloride (ChCl) and monosodium glutamate (MSG) as hydrogen bond acceptors (HBAs). The hydrogen-bonding interactions between the starting materials were determined. The efficiency of the LTTMs in removing lignin from oil palm biomass residues, empty fruit bunch (EFB) was also evaluated. The removal of amorphous hemicellulose and lignin after the pretreatment process resulted in an enhanced digestibility and thermal degradability of biomass.
[Mh] Termos MeSH primário: Cactaceae
Malatos
Glutamato de Sódio
[Mh] Termos MeSH secundário: Biomassa
Colina
Peróxido de Hidrogênio
Hidrólise
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Malates); 0 (Solvents); 817L1N4CKP (malic acid); BBX060AN9V (Hydrogen Peroxide); N91BDP6H0X (Choline); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  5 / 1696 MEDLINE  
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[PMID]:28821180
[Au] Autor:Schwartz C; Chabanet C; Szleper E; Feyen V; Issanchou S; Nicklaus S
[Ad] Endereço:Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Université Bourgogne Franche-Comté, 17 rue Sully, BP 86510, 21065 Dijon cedex, France.
[Ti] Título:Infant Acceptance of Primary Tastes and Fat Emulsion: Developmental Changes and Links with Maternal and Infant Characteristics.
[So] Source:Chem Senses;42(7):593-603, 2017 Sep 01.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies on taste acceptance have been conducted taste-by-taste and with a cross-sectional design. The aim of this study was to longitudinally evaluate the acceptance of sweet, salty, bitter, sour and umami solutions, and a fat emulsion comparatively in a birth cohort from 3 to 20 months old. The acceptance of each taste relative to water was defined using proportional variables that are based on ingestion (IR) or liking evaluated by the experimenter (LR). These data were analyzed with mixed models that accounted for age and subject effects (minimum 152 observations/age/taste; maximum 216). For saltiness, acceptance increased sharply between 3 and 12 months old. The trajectories of acceptance were parallel for sweetness, sourness, and the umami tastes between 3 and 20 months old, with sweetness being preferred. Between 12 and 20 months old, the acceptance of all tastes, except bitterness, decreased, and at 20 months old, only sweetness was not rejected. The acceptance of bitterness remained stable. For the fat emulsion, acceptance evolved from indifference to rejection. The acceptance of saltiness and umami tastes were lower in girls than boys at 20 months old. The acceptance of the fat emulsion was higher in infants who were born heavier and taller. At 20 months old, the fat emulsion acceptance was higher in infants who were born from mothers with a higher prepregnancy body mass index. Finally, the taste differential reactivity (the standard deviation of the IRs) significantly increased from 3 to 20 months old.
[Mh] Termos MeSH primário: Óleos Vegetais/farmacologia
Paladar/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Índice de Massa Corporal
Ácido Cítrico/farmacologia
Estudos Transversais
Feminino
Preferências Alimentares/efeitos dos fármacos
Seres Humanos
Lactente
Lactose/farmacologia
Masculino
Mães
Fatores Sexuais
Cloreto de Sódio/farmacologia
Glutamato de Sódio/farmacologia
Percepção Gustatória
Ureia/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 2968PHW8QP (Citric Acid); 451W47IQ8X (Sodium Chloride); 8W8T17847W (Urea); J2B2A4N98G (Lactose); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1093/chemse/bjx040


  6 / 1696 MEDLINE  
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[PMID]:28821179
[Au] Autor:Zhang L; Shi B; Wang H; Zhao L; Chen Z
[Ad] Endereço:College of Food and Biology Engineering, Zhejiang Gongshang University, Hangzhou 310018, China.
[Ti] Título:Pungency Evaluation of Hydroxyl-Sanshool Compounds After Dissolution in Taste Carriers Per Time-Related Characteristics.
[So] Source:Chem Senses;42(7):575-584, 2017 Sep 01.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was conducted to investigate the sensory characteristics and temporal migration of hydroxyl-sanshool compounds at slight and moderate concentrations after dissolution in ethanol-water, saccharose, NaCl, and MSG via 2-AFC, time intensity (TI) and temporal dominance of sensations (TDS) methods. The pungency detection threshold (DT) was suppressed in saccharose while NaCl and MSG solutions showed no effect on pungency DT. The area under the curve (AUC) of pungency increased in NaCl and MSG solutions and decreased significantly in saccharose solution. Imax (maximal intensity) also increased in NaCl and MSG at low concentrations of hydroxyl-sanshool compounds. The temporally dominant sensations and migration of said sensations across the oral cavity differed among different carriers. Low levels of pungency compounds were characterized by tingling first in the tongue tip and ending in the lips, while moderate levels of the compound produced tingling, astringency, vibrating, and numbing from the tongue tip to the bilateral sides of the tongue, lips, palate, cheek mucosa, and surface of the tongue over time. There were significant differences in the maximum rate, peak time, and duration of any dominant sensation, as well as in the duration of sensation in the lips, tongue tip, and bilateral sides of the tongue. This study provides a dynamic profile of consuming pungent food, which provides a reference not only for the design of new food products with desirable pungency, but also as a scientific basis for the application of pungent compounds within the food and catering industry.
[Mh] Termos MeSH primário: Amidas/farmacologia
Paladar/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Feminino
Seres Humanos
Lábio/fisiologia
Masculino
Mucosa Bucal/fisiologia
Curva ROC
Cloreto de Sódio/farmacologia
Glutamato de Sódio/farmacologia
Sacarose/farmacologia
Limiar Gustativo/efeitos dos fármacos
Fatores de Tempo
Língua/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 451W47IQ8X (Sodium Chloride); 504-97-2 (sanshool); 57-50-1 (Sucrose); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1093/chemse/bjx038


  7 / 1696 MEDLINE  
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[PMID]:28605507
[Au] Autor:Eddy MC; Eschle BK; Delay ER
[Ad] Endereço:Department of Biology and Vermont Chemical Senses Group, University of Vermont,109 Carrigan Drive, Burlington, VT 05405,USA.
[Ti] Título:Comparison of the Tastes of L-Alanine and Monosodium Glutamate in C57BL/6J Wild Type and T1r3 Knockout Mice.
[So] Source:Chem Senses;42(7):563-573, 2017 Sep 01.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous research showed that L-alanine and monosodium L-glutamate elicit similar taste sensations in rats. This study reports the results of behavioral experiments designed to compare the taste capacity of C57BL/6J wild type and T1r3- mice for these 2 amino acids. In conditioned taste aversion (CTA) experiments, wild-type mice exhibited greater sensitivity than knockout mice for both L-amino acids, although knockout mice were clearly able to detect both amino acids at 50 mM and higher concentrations. Generalization of CTA between L-alanine and L-glutamate was bidirectionally equivalent for both mouse genotypes, indicating that both substances elicited similar tastes in both genotypes. This was verified by the discrimination experiments in which both mouse genotypes performed at or near chance levels at 75 and 150 mM. Above 150 mM, discrimination performance improved, suggesting the taste qualities of the 2 L-amino acids are not identical. No differences between knockout and wild-type mice in discrimination ability were detected. These results indicate that while the T1r3 receptor is important for tasting L-alanine and L-glutamate, other receptors are also important for tasting these amino acids.
[Mh] Termos MeSH primário: Alanina/farmacologia
Glutamato de Sódio/farmacologia
Paladar/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Análise Discriminante
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Receptores Acoplados a Proteínas-G/deficiência
Receptores Acoplados a Proteínas-G/genética
Limiar Gustativo/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, G-Protein-Coupled); 0 (taste receptors, type 1); OF5P57N2ZX (Alanine); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1093/chemse/bjx037


  8 / 1696 MEDLINE  
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[PMID]:28528338
[Au] Autor:da Silva Franco CC; Previate C; de Barros Machado KG; Piovan S; Miranda RA; Prates KV; Moreira VM; de Oliveira JC; Barella LF; Gomes RM; Francisco FA; Martins IP; Pavanello A; Ribeiro TA; Tófolo LP; Malta A; de Souza AA; Alves VS; da Silva Silveira S; Marçal Natali MR; Fernando Besson JC; de Morais H; de Souza HM; de Sant Anna JR; Alves de Castro Prado MA; de Freitas Mathias PC
[Ad] Endereço:Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.
[Ti] Título:Chronic Glibenclamide Treatment Attenuates Walker-256 Tumour Growth in Prediabetic Obese Rats.
[So] Source:Cell Physiol Biochem;42(1):81-90, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms underlying this observation remain unclear. The aim of the present work was to evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth. METHODS: Neonatal rats were treated with monosodium L-glutamate (MSG) to induce prediabetes. Control and MSG groups were treated with Gli (2 mg/kg body weight/day) from weaning to 100 days old. After Gli treatment, the control and MSG rats were grafted with Walker-256 tumour cells. After 14 days, grafted rats were euthanized, and tumour weight as well as glucose homeostasis were evaluated. RESULTS: Treatment with Gli normalized tissue insulin sensitivity and glucose tolerance, suppressed fasting hyperinsulinaemia, reduced fat tissue accretion in MSG rats, and attenuated tumour growth by 27% in control and MSG rats. CONCLUSIONS: Gli treatment also resulted in a large reduction in the number of PCNA-positive tumour cells. Although treatment did improve the metabolism of pre-diabetic MSG-rats, tumour growth inhibition may be a more direct effect of glibenclamide.
[Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos
Glibureto/farmacologia
Estado Pré-Diabético/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Caquexia/etiologia
Linhagem Celular Tumoral
Glucose/metabolismo
Glibureto/uso terapêutico
Hiperinsulinismo/prevenção & controle
Hipoglicemiantes/farmacologia
Hipoglicemiantes/uso terapêutico
Imuno-Histoquímica
Masculino
Obesidade/complicações
Obesidade/metabolismo
Obesidade/patologia
Estado Pré-Diabético/etiologia
Antígeno Nuclear de Célula em Proliferação/metabolismo
Ratos
Ratos Wistar
Glutamato de Sódio/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Proliferating Cell Nuclear Antigen); IY9XDZ35W2 (Glucose); SX6K58TVWC (Glyburide); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE
[do] DOI:10.1159/000477117


  9 / 1696 MEDLINE  
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[PMID]:28303588
[Au] Autor:Abolaji AO; Olaiya CO; Oluwadahunsi OJ; Farombi EO
[Ad] Endereço:Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
[Ti] Título:Dietary consumption of monosodium L-glutamate induces adaptive response and reduction in the life span of Drosophila melanogaster.
[So] Source:Cell Biochem Funct;35(3):164-170, 2017 Apr.
[Is] ISSN:1099-0844
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adaptive response is the ability of an organism to better counterattack stress-induced damage in response to a number of different cytotoxic agents. Monosodium L-glutamate (MSG), the sodium salt of amino acid glutamate, is commonly used as a food additive. We investigated the effects of MSG on the life span and antioxidant response in Drosophila melanogaster (D. melanogaster). Both genders (1 to 3 days old) of flies were fed with diet containing MSG (0.1, 0.5, and 2.5-g/kg diet) for 5 days to assess selected antioxidant and oxidative stress markers, while flies for longevity were fed for lifetime. Thereafter, the longevity assay, hydrogen peroxide (H O ), and reactive oxygen and nitrogen species levels were determined. Also, catalase, glutathione S-transferase and acetylcholinesterase activities, and total thiol content were evaluated in the flies. We found that MSG reduced the life span of the flies by up to 23% after continuous exposure. Also, MSG increased reactive oxygen and nitrogen species and H O generations and total thiol content as well as the activities of catalase and glutathione S-transferase in D. melanogaster (P < .05). In conclusion, consumption of MSG for 5 days by D. melanogaster induced adaptive response, but long-term exposure reduced life span of flies. This study may therefore have public health significance in humans, and thus, moderate consumption of MSG is advocated by the authors.
[Mh] Termos MeSH primário: Adaptação Fisiológica/efeitos dos fármacos
Antioxidantes/metabolismo
Dieta
Drosophila melanogaster/crescimento & desenvolvimento
Aromatizantes/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Glutamato de Sódio/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Catalase/metabolismo
Drosophila melanogaster/efeitos dos fármacos
Drosophila melanogaster/metabolismo
Glutationa Transferase/metabolismo
Compostos de Sulfidrila/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavoring Agents); 0 (Sulfhydryl Compounds); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase); EC 3.1.1.7 (Acetylcholinesterase); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1002/cbf.3259


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[PMID]:28298151
[Au] Autor:Taheri S
[Ad] Endereço:Children's Hospital of Western Ontario, Department of Academic Paediatrics, London, Canada.
[Ti] Título:Effect of exclusion of frequently consumed dietary triggers in a cohort of children with chronic primary headache.
[So] Source:Nutr Health;23(1):47-50, 2017 Mar.
[Is] ISSN:0260-1060
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although dietary factors are known to trigger headaches, the relationship between food and headache in children remains unclear. This prospective, observational case series aimed to evaluate the effect of exclusion of frequently-consumed foods in a cohort of children with headache. METHODS: One hundred and fifteen children aged 3-15 (mean 10.5) years with primary headache were followed in a paediatric outpatient clinic. Patients who frequently consumed foods or food additives known to trigger headaches were advised to exclude them for six weeks and to return for follow-up with headache and food diary. RESULTS: One hundred patients attended follow-up. Of these 13 (13%) did not respond to dietary exclusion; 87 (87%) achieved complete resolution of headaches by exclusion of 1-3 of the identified food(s). Caffeine was the most common implicated trigger (28), followed by monosodium glutamate (25), cocoa (22), aspartame (13), cheese (13), citrus (10) and nitrites (six). One patient was sensitive to tomatoes. CONCLUSIONS: This study demonstrates the potential scale and significance of seven frequently consumed foods or food additives as triggers for primary headache in children. Also this is the first study to show that headaches can be triggered by the cumulative effect of a food that is frequently consumed, rather than by single time ingestion.
[Mh] Termos MeSH primário: Dieta/efeitos adversos
Comportamento Alimentar
Cefaleia/dietoterapia
Transtornos de Enxaqueca/dietoterapia
[Mh] Termos MeSH secundário: Adolescente
Aspartame/administração & dosagem
Aspartame/efeitos adversos
Cacau/efeitos adversos
Cafeína/administração & dosagem
Cafeína/efeitos adversos
Queijo/efeitos adversos
Criança
Pré-Escolar
Chocolate/efeitos adversos
Citrus/efeitos adversos
Registros de Dieta
Feminino
Aditivos Alimentares/administração & dosagem
Aditivos Alimentares/efeitos adversos
Cefaleia/etiologia
Transtornos da Cefaleia/dietoterapia
Transtornos da Cefaleia/etiologia
Seres Humanos
Masculino
Transtornos de Enxaqueca/etiologia
Nitritos/administração & dosagem
Nitritos/efeitos adversos
Fatores Desencadeantes
Estudos Prospectivos
Glutamato de Sódio/administração & dosagem
Glutamato de Sódio/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives); 0 (Nitrites); 3G6A5W338E (Caffeine); W81N5U6R6U (Sodium Glutamate); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1177/0260106016688699



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