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[PMID]:28851525
[Au] Autor:Olkowicz M; Debski J; Jablonska P; Dadlez M; Smolenski RT
[Ad] Endereço:Department of Biochemistry, Medical University of Gdansk, 1 Debinki St., 80-211 Gdansk, Poland; Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego St., 60-627 Poznan, Poland. Electronic address: olkowicz@up.poznan.pl.
[Ti] Título:Application of a new procedure for liquid chromatography/mass spectrometry profiling of plasma amino acid-related metabolites and untargeted shotgun proteomics to identify mechanisms and biomarkers of calcific aortic stenosis.
[So] Source:J Chromatogr A;1517:66-78, 2017 Sep 29.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Calcific aortic valve stenosis (CAS) increasingly affects our ageing population, but the mechanisms of the disease and its biomarkers are not well established. Recently, plasma amino acid-related metabolite (AA) profiling has attracted attention in studies on pathology and development of biomarkers of cardiovascular diseases, but has not been studied in CAS. To evaluate the potential relationship between CAS and AA metabolome, a new ion-pairing reversed-phase liquid chromatography-tandem mass spectrometry (IP-RPLC-MS/MS) method has been developed and validated for simultaneous determination of 43 AAs in plasma of stenotic patients and age-matched control subjects. Furthermore, untargeted mass spectrometry-based proteomic analysis and confirmatory ELISA assays were performed. The method developed offered high accuracy (intra-assay imprecision averaged 4.4% for all compounds) and sensitivity (LOQ within 0.01-0.5µM). We found that 22 AAs and three AA ratios significantly changed in the CAS group as compared to control. The most pronounced differences were observed in urea cycle-related AAs and branched-chain AA (BCAA)-related AAs. The contents of asymmetric dimethylarginine (ADMA) and its monomethylated derivative (NMMA) were increased by 30-64% with CAS. The arginine/ADMA and Fischer's ratios as well as arginine, homoarginine, ADMA, symmetric dimethylarginine, hydroxyproline, betaine and 3-methylhistidine correlated with cardiac function-related parameters and concomitant systemic factors in the CAS patients. The results of proteomic analysis were consistent with involvement of inflammation, lipid abnormalities, hemostasis and extracellular matrix remodeling in CAS. In conclusion, changes in plasma AA profile and protein pattern that we identified in CAS provide information relevant to pathomechanisms and may deliver new biomarkers of the disease.
[Mh] Termos MeSH primário: Estenose da Valva Aórtica/sangue
Valva Aórtica/patologia
Biomarcadores/sangue
Análise Química do Sangue/métodos
Calcinose/sangue
Cromatografia Líquida
Proteômica
Espectrometria de Massas em Tandem
[Mh] Termos MeSH secundário: Cromatografia de Fase Reversa
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Masculino
Metilistidinas/sangue
Meia-Idade
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Methylhistidines); 368-16-1 (3-methylhistidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE


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[PMID]:28541155
[Au] Autor:Loftus JP; Center SA; Lucy JM; Stanton JA; McDonough SP; Peters-Kennedy J; Arceneaux KA; Bechtold MA; Bennett CL; Bradbury CA; Cline MG; Hall-Fonte DL; Hammer-Landrum JF; Huntingford JL; Marshall J; Sharpe KS; Redin JL; Selva ST; Lucia TA
[Ti] Título:Characterization of aminoaciduria and hypoaminoacidemia in dogs with hepatocutaneous syndrome.
[So] Source:Am J Vet Res;78(6):735-744, 2017 Jun.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To characterize aminoaciduria and plasma amino acid concentrations in dogs with hepatocutaneous syndrome (HCS). ANIMALS 20 client-owned dogs of various breeds and ages. PROCEDURES HCS was definitively diagnosed on the basis of liver biopsy specimens (n = 12), gross and histologic appearance of skin lesions (4), and examination of skin and liver biopsy specimens (2) and presumptively diagnosed on the basis of cutaneous lesions with compatible clinicopathologic and hepatic ultrasonographic (honeycomb or Swiss cheese pattern) findings (2). Amino acid concentrations in heparinized plasma and urine (samples obtained within 8 hours of each other) were measured by use of ion exchange chromatography. Urine creatinine concentration was used to normalize urine amino acid concentrations. Plasma amino acid values were compared relative to mean reference values; urine-corrected amino acid values were compared relative to maximal reference values. RESULTS All dogs had generalized hypoaminoacidemia, with numerous amino acid concentrations < 50% of mean reference values. The most consistent and severe abnormalities involved glutamine, proline, cysteine, and hydroxyproline, and all dogs had marked lysinuria. Urine amino acids exceeding maximum reference values (value > 1.0) included lysine, 1-methylhistidine, and proline. CONCLUSIONS AND CLINICAL RELEVANCE Hypoaminoacidemia in dogs with HCS prominently involved amino acids associated with the urea cycle and synthesis of glutathione and collagen. Marked lysinuria and prolinuria implicated dysfunction of specific amino acid transporters and wasting of amino acids essential for collagen synthesis. These findings may provide a means for tailoring nutritional support and for facilitating HCS diagnosis.
[Mh] Termos MeSH primário: Aminoácidos/sangue
Aminoácidos/urina
Doenças do Cão/sangue
Doenças do Cão/urina
Hepatopatias/veterinária
Dermatopatias/veterinária
[Mh] Termos MeSH secundário: Animais
Cruzamento
Cães
Feminino
Fígado/patologia
Hepatopatias/sangue
Hepatopatias/urina
Masculino
Metilistidinas
Dermatopatias/sangue
Dermatopatias/urina
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Methylhistidines); 332-80-9 (1-methylhistidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.6.735


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[PMID]:28446262
[Au] Autor:Zheng L; Zuo F; Zhao S; He P; Wei H; Xiang Q; Pang J; Peng J
[Ad] Endereço:1Department of Animal Nutrition and Feed Science,College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070,People's Republic of China.
[Ti] Título:Dietary supplementation of branched-chain amino acids increases muscle net amino acid fluxes through elevating their substrate availability and intramuscular catabolism in young pigs.
[So] Source:Br J Nutr;117(7):911-922, 2017 Apr.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Branched-chain amino acids (BCAA) have been clearly demonstrated to have anabolic effects on muscle protein synthesis. However, little is known about their roles in the regulation of net AA fluxes across skeletal muscle in vivo. This study was aimed to investigate the effect and related mechanisms of dietary supplementation of BCAA on muscle net amino acid (AA) fluxes using the hindlimb flux model. In all fourteen 4-week-old barrows were fed reduced-protein diets with or without supplemental BCAA for 28 d. Pigs were implanted with carotid arterial, femoral arterial and venous catheters, and fed once hourly with intraarterial infusion of p-amino hippurate. Arterial and venous plasma and muscle samples were obtained for the measurement of AA, branched-chain α-keto acids (BCKA) and 3-methylhistidine (3-MH). Metabolomes of venous plasma were determined by HPLC-quadrupole time-of-flight-MS. BCAA-supplemented group showed elevated muscle net fluxes of total essential AA, non-essential AA and AA. As for individual AA, muscle net fluxes of each BCAA and their metabolites (alanine, glutamate and glutamine), along with those of histidine, methionine and several functional non-essential AA (glycine, proline and serine), were increased by BCAA supplementation. The elevated muscle net AA fluxes were associated with the increase in arterial and intramuscular concentrations of BCAA and venous metabolites including BCKA and free fatty acids, and were also related to the decrease in the intramuscular concentration of 3-MH. Correlation analysis indicated that muscle net AA fluxes are highly and positively correlated with arterial BCAA concentrations and muscle net BCKA production. In conclusion, supplementing BCAA to reduced-protein diet increases the arterial concentrations and intramuscular catabolism of BCAA, both of which would contribute to an increase of muscle net AA fluxes in young pigs.
[Mh] Termos MeSH primário: Aminoácidos de Cadeia Ramificada/administração & dosagem
Anabolizantes/administração & dosagem
Dieta com Restrição de Proteínas/veterinária
Desenvolvimento Muscular
Proteínas Musculares/biossíntese
Músculo Esquelético/metabolismo
Regulação para Cima
[Mh] Termos MeSH secundário: Aminoácidos/sangue
Aminoácidos/metabolismo
Aminoácidos de Cadeia Ramificada/sangue
Aminoácidos de Cadeia Ramificada/metabolismo
Anabolizantes/sangue
Anabolizantes/metabolismo
Animais
China
Cruzamentos Genéticos
Dieta com Restrição de Proteínas/efeitos adversos
Ácidos Graxos não Esterificados/sangue
Ácidos Graxos não Esterificados/metabolismo
Membro Posterior
Técnicas de Diluição do Indicador
Cetoácidos/sangue
Cetoácidos/metabolismo
Masculino
Metabolômica/métodos
Metilistidinas/sangue
Metilistidinas/metabolismo
Músculo Esquelético/irrigação sanguínea
Músculo Esquelético/crescimento & desenvolvimento
Orquiectomia/veterinária
Fluxo Sanguíneo Regional
Sus scrofa
Ganho de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amino Acids); 0 (Amino Acids, Branched-Chain); 0 (Anabolic Agents); 0 (Fatty Acids, Nonesterified); 0 (Keto Acids); 0 (Methylhistidines); 0 (Muscle Proteins); 368-16-1 (3-methylhistidine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000757


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[PMID]:28358856
[Au] Autor:Cheng M; Gao T; Xi F; Cao C; Chen Y; Zhao C; Li Q; Yu W
[Ad] Endereço:Medical School of Nanjing University,Nanjing, Jiangsu, P.R China.
[Ti] Título:Dexmedetomidine ameliorates muscle wasting and attenuates the alteration of hypothalamic neuropeptides and inflammation in endotoxemic rats.
[So] Source:PLoS One;12(3):e0174894, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dexmedetomidine is generally used for sedaton in critically ill, it could shorten duration of mechanical ventilation, ICU stay and lower basic metabolism. However, the exact mechanism of these positive effects remains unkown. Here we investigated the hypothesis that dexmedetomidine could ameliorate muscle wasting in endotoxemic rats and whether it was related to hypothalamic neuropeptides alteration and inflammation. Fourty-eight adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) (5 mg/kg) or saline, followed by 50 µg/kg dexmedetomidine or saline administration via the femoral vein catheter (infusion at 5 µg·kg-1·hr-1). Twenty-four hours after injection, hypothalamus tissues and skeletal muscle were obtained. Muscle wasting was measured by the mRNA expression of two E3 ubiquitin ligases, muscle atrophy F-box (MAFbx) and muscle ring finger 1 (MuRF-1) as well as 3-methylhistidine (3-MH) and tyrosine release. Hypothalamic inflammatory markers and neuropeptides expression were also detected in all four groups. Results showed that LPS administration led to significant increase in hypothalamic inflammation together with muscle wasting. Increased hypothalamic neuropeptides, proopiomelanocortin (POMC), cocaine and amphetamine-related transcript (CART) and neuropeptides Y (NPY) and decreased agouti-related protein (AgRP) were also observed. Meanwhile dexmedetomidine administration ameliorated muscle wasting, hypothalamic inflammation and modulated the alteration of neuropeptides, POMC, CART and AgRP, in endotoxemic rats. In conclusion, dexmedetomidine could alleviate muscle wasting in endotoxemic rats, and it could also attenuate the alteration of hypothalamic neuropeptides and reduce hypothalamic inflammation.
[Mh] Termos MeSH primário: Dexmedetomidina/uso terapêutico
Endotoxemia/tratamento farmacológico
Hipotálamo/metabolismo
Inflamação/tratamento farmacológico
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/patologia
Neuropeptídeos/metabolismo
[Mh] Termos MeSH secundário: Proteína Relacionada com Agouti/metabolismo
Animais
Endotoxemia/metabolismo
Hipotálamo/efeitos dos fármacos
Inflamação/metabolismo
Interleucina-1/metabolismo
Masculino
Metilistidinas/metabolismo
Músculo Esquelético/metabolismo
Atrofia Muscular/tratamento farmacológico
Atrofia Muscular/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Neuropeptídeo Y/metabolismo
Pró-Opiomelanocortina/metabolismo
Ratos
Ratos Sprague-Dawley
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agouti-Related Protein); 0 (Interleukin-1); 0 (Methylhistidines); 0 (Nerve Tissue Proteins); 0 (Neuropeptide Y); 0 (Neuropeptides); 0 (Tumor Necrosis Factor-alpha); 0 (cocaine- and amphetamine-regulated transcript protein); 368-16-1 (3-methylhistidine); 66796-54-1 (Pro-Opiomelanocortin); 67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174894


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[PMID]:27975177
[Au] Autor:Mirnaghizadeh SV; Zendehdel M; Babapour V
[Ad] Endereço:Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, PO Box: 14155-6453, Tehran, Iran.
[Ti] Título:Involvement of histaminergic and noradrenergic receptors in the oxytocin-induced food intake in neonatal meat-type chicks.
[So] Source:Vet Res Commun;41(1):57-66, 2017 Mar.
[Is] ISSN:1573-7446
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Oxytocin neurons have a physiological role in food intake and energy balance. Several studies have shown that central histaminergic and adrenergic systems synapse on oxytocin neurons but there is no information for their interaction on food intake regulation in birds. The purpose of this study was to examine the effects of intracerebroventricular (ICV) injection of α-fluoromethylhistidine (α-FMH, histidine decarboxylase inhibitor), chlorpheniramine (histamine H1 receptors antagonist), famotidine (histamine H2 receptors antagonist), thioperamide (histamine H3 receptors antagonist), prazosin (α1 receptor antagonist), yohimbine (α2 receptor antagonist), metoprolol (ß1 adrenergic receptor antagonist), ICI 118,551 (ß2 adrenergic receptor antagonist) and SR59230R (ß3 adrenergic receptor antagonist) on oxytocin-induced hypophagia in 3-h food-deprived (FD ) neonatal broiler chicken. In Experiment 1, 3 h-fasted chicks were given an ICV injection of saline, α-FMH (250 nmol), oxytocin (10 µg) and co-injection of α-FMH + oxytocin. Experiments 2-9 were similar to experiment 1 except birds were injected with chlorpheniramine (300 nmol), famotidine (82 nmol), thioperamide (300 nmol), prazosin (10 nmol), yohimbine (13 nmol), metoprolol (24 nmol), ICI 118,551(5 nmol) and SR59230R (20 nmol) instead of α-FMH, respectively. After injection cumulative food intake was measured until 120 min post injection. According to the results, ICV injection of oxytocin significantly decreased food intake in broiler chickens (P < 0.001). ICV injection of α-FMH significantly attenuated hypophagic effect of oxytocin (P < 0.001). Also, co-injection of chlorpheniramine plus oxytocin significantly decreased the effect of oxytocin on food intake (P < 0.001). Co-administration of thioperamide and oxytocin significantly amplified hypophagic effect of oxytocin in chickens (P < 0.001). In addition, ICI 118,551 attenuated hypophagic effect of oxytocin (P < 0.001); while famotidine, prazosin, yohimbine, metoprolol and SR59230R had no effect on oxytocin- induced food intake in FD3 broiler chickens. These results suggest that the effect of oxytocin on food intake is probably mediated by histaminergic (via H1 and H3 receptors) and noradrenergic (via ß2 receptors) systems in broiler chickens.
[Mh] Termos MeSH primário: Neurônios Adrenérgicos/metabolismo
Galinhas/fisiologia
Ingestão de Alimentos/efeitos dos fármacos
Comportamento Alimentar/fisiologia
Ocitocina/farmacologia
Receptores Histamínicos/metabolismo
[Mh] Termos MeSH secundário: Neurônios Adrenérgicos/efeitos dos fármacos
Animais
Animais Recém-Nascidos
Metilistidinas/farmacologia
Ligação Proteica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylhistidines); 0 (Receptors, Histamine); 50-56-6 (Oxytocin); 70050-43-0 (alpha-fluoromethylhistidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1007/s11259-016-9672-7


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[PMID]:28036059
[Au] Autor:Zhou Z; Vailati-Riboni M; Luchini DN; Loor JJ
[Ad] Endereço:Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA. zzhou32@illinois.edu.
[Ti] Título:Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status.
[So] Source:Nutrients;9(1), 2016 Dec 29.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to profile plasma amino acids (AA) and derivatives of their metabolism during the periparturient period in response to supplemental rumen-protected methionine (MET) or rumen-protected choline (CHOL). Forty cows were fed from -21 through 30 days around parturition in a 2 × 2 factorial design a diet containing MET or CHOL. MET supply led to greater circulating methionine and proportion of methionine in the essential AA pool, total AA, and total sulfur-containing compounds. Lysine in total AA also was greater in these cows, indicating a better overall AA profile. Sulfur-containing compounds (cystathionine, cystine, homocystine, and taurine) were greater in MET-fed cows, indicating an enriched sulfur-containing compound pool due to enhanced transsulfuration activity. Circulating essential AA and total AA concentrations were greater in cows supplied MET due to greater lysine, arginine, tryptophan, threonine, proline, asparagine, alanine, and citrulline. In contrast, CHOL supply had no effect on essential AA or total AA, and only tryptophan and cystine were greater. Plasma 3-methylhistidine concentration was lower in response to CHOL supply, suggesting less tissue protein mobilization in these cows. Overall, the data revealed that enhanced periparturient supply of MET has positive effects on plasma AA profiles and overall antioxidant status.
[Mh] Termos MeSH primário: Aminoácidos/sangue
Fenômenos Fisiológicos da Nutrição Animal
Carbono/metabolismo
Colina/administração & dosagem
Metionina/administração & dosagem
[Mh] Termos MeSH secundário: Aminoácidos Essenciais/sangue
Ração Animal/análise
Animais
Antioxidantes/metabolismo
Bovinos
Colina/sangue
Cistationina/sangue
Cistina/sangue
Dieta/veterinária
Suplementos Nutricionais
Feminino
Homocistina/sangue
Fígado/metabolismo
Metionina/sangue
Metilistidinas/sangue
Parto
Gravidez
Prenhez
Rúmen/metabolismo
Taurina/sangue
Triptofano/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amino Acids); 0 (Amino Acids, Essential); 0 (Antioxidants); 0 (Methylhistidines); 1EQV5MLY3D (Taurine); 368-16-1 (3-methylhistidine); 375YFJ481O (Cystathionine); 462-10-2 (Homocystine); 48TCX9A1VT (Cystine); 7440-44-0 (Carbon); 8DUH1N11BX (Tryptophan); AE28F7PNPL (Methionine); N91BDP6H0X (Choline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27055887
[Au] Autor:Shimamoto S; Ijiri D; Nakashima K; Kawaguchi M; Ishimaru Y; Furukawa A; Ohtsuka A
[Ad] Endereço:a Department of Biochemical Science and Technology , Kagoshima University , Kagoshima , Japan.
[Ti] Título:Clenbuterol changes phosphorylated FOXO1 localization and decreases protein degradation in the sartorius muscle of neonatal chicks.
[So] Source:Biosci Biotechnol Biochem;80(8):1499-504, 2016 Aug.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To investigate the intracellular signaling mechanisms by which clenbuterol reduces muscle protein degradation, we examined the phosphorylation level and intracellular localization of FOXO1 in the sartorius muscle of neonatal chicks. One-day-old chicks were given a single intraperitoneal injection of clenbuterol (0.1 mg/kg body weight). Three hours after injection, AKT protein was phosphorylated in the sartorius muscle by clenbuterol injection. Coincidentally, clenbuterol increased cytosolic level of phosphorylated FOXO1 protein, while it decreased nuclear level of FOXO1 protein in the sartorius muscle. Furthermore, clenbuterol decreased the expression of mRNAs for muscle-specific ubiquitin ligases (atrogin-1/MAFbx and MuRF1) in the sartorius muscle accompanied by decreased plasma 3-methylhistidine concentration, an index of muscle protein degradation, at 3 h after injection. These results suggested that, in the sartorius muscle of the chicks, clenbuterol changed the intracellular localization of phosphorylated FOXO1, and consequently decreased protein degradation via suppressing the expression of genes encoding muscle-specific ubiquitin ligases.
[Mh] Termos MeSH primário: Proteínas Aviárias/genética
Clembuterol/farmacologia
Proteína Forkhead Box O1/genética
Músculo Esquelético/efeitos dos fármacos
Proteínas Ligases SKP Culina F-Box/genética
Simpatomiméticos/farmacologia
Ubiquitina-Proteína Ligases/genética
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Proteínas Aviárias/metabolismo
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Galinhas
Citoplasma/efeitos dos fármacos
Citoplasma/metabolismo
Proteína Forkhead Box O1/metabolismo
Regulação da Expressão Gênica
Injeções Intraperitoneais
Metilistidinas/sangue
Músculo Esquelético/metabolismo
Fosforilação/efeitos dos fármacos
Proteólise/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteínas Ligases SKP Culina F-Box/antagonistas & inibidores
Proteínas Ligases SKP Culina F-Box/metabolismo
Ubiquitina-Proteína Ligases/antagonistas & inibidores
Ubiquitina-Proteína Ligases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Avian Proteins); 0 (Forkhead Box Protein O1); 0 (Methylhistidines); 0 (Sympathomimetics); 368-16-1 (3-methylhistidine); EC 2.3.2.27 (SKP Cullin F-Box Protein Ligases); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); XTZ6AXU7KN (Clenbuterol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160409
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2016.1158629


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[PMID]:26982638
[Au] Autor:Gulsun M; Oznur T; Aydemir E; Ozcelik F; Erdem M; Zincir S; Akgul O; Kurt Y
[Ad] Endereço:a Department of Psychiatry , Gulhane Military Medical Academy , Ankara , Turkey ;
[Ti] Título:Possible relationship between amino acids, aggression and psychopathy.
[So] Source:Int J Psychiatry Clin Pract;20(2):91-100, 2016.
[Is] ISSN:1471-1788
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Aggressive behaviour is associated with reduced serotonin metabolism in the brain, but there is not enough knowledge on potential changes of the serotonin precursor levels among violent offenders. In this study, we aimed to evaluate the relationships among the tendency of psychopathy, anger and the basic amino acids. METHODS: Fifty-two young adult male patients with antisocial personality disorder (APD) and 30 healthy men included the study. Serum amino acid levels were measured by HPLC method. Aggression questionnaire and Hare Psychopathology Scale were used for all participants. RESULTS: Blood levels of phosphoserine, aspartic acid, glutamic acid, aminoadipic acid and 1-methylhistidine in group of patients with APD were significantly higher than the control group. Blood levels of TRP, asparagine, citrulline, cystine, isoleucine, tyrosine, histidine, hydroxylysine, lysine, ethanolamine and arginine in the group of patients were found lower than the control group. A significant positive correlation between anger scores and histidine, methionine and GABA was found. GABA and methionine showed a significant correlation with the indirect aggression score. CONCLUSION: Our study showed a relationship between serum amino acid levels and the scores of aggression and psychopathy. We think that this is a productive research area for understanding the relationship among biochemical factors, aggression and psychopathy.
[Mh] Termos MeSH primário: Agressão
Aminoácidos/sangue
Transtorno da Personalidade Antissocial/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Seres Humanos
Masculino
Metilistidinas/sangue
Fosfosserina/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Methylhistidines); 17885-08-4 (Phosphoserine); 332-80-9 (1-methylhistidine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE
[do] DOI:10.3109/13651501.2016.1144771


  9 / 1185 MEDLINE  
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[PMID]:26924422
[Au] Autor:Zendehdel M; Baghbanzadeh A; Aghelkohan P; Hassanpour S
[Ad] Endereço:a Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine , University of Tehran , 14155-6453 , Tehran , Iran.
[Ti] Título:Central histaminergic system interplay with suppressive effects of immune challenge on food intake in chicken.
[So] Source:Br Poult Sci;57(2):271-9, 2016 Apr.
[Is] ISSN:1466-1799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the current study was to investigate the interaction of the lipopolysaccharide (LPS) and histaminergic systems on appetite regulation in broilers. Effects of intracerebroventricular (ICV) injection of α-fluoromethylhistidine (α-FMH, histidine decarboxylase inhibitor), chlorpheniramine (histamine H1 receptor antagonist), famotidine (histamine H2 receptor antagonist) and thioperamide (histamine H3 receptor antagonist) on LPS-induced hypophagia in broilers were studied. A total of 128 broilers were randomly allocated into 4 experiments (4 groups and 8 replications in each experiment). A cannula was surgically implanted into the lateral ventricle. In Experiment 1, broilers were ICV injected with LPS (20 ng) prior to α-FMH (250 nmol). In Experiment 2, chickens were ICV injected with LPS followed by chlorpheniramine (300 nmol). In Experiment 3, broilers were ICV injected with famotidine (82 nmol) after LPS (20 ng). In Experiment 4, ICV injection of LPS was followed by thioperamide (300 nmol). Then, cumulative food intake was recorded until 4 h post-injection. According to the results, LPS significantly decreased food intake. Chlorpheniramine significantly amplified food intake, and LPS-induced hypophagia was lessened by injection of chlorpheniramine. α-FMH, famotidine and thioperamide had no effect on LPS-induced hypophagia. These results suggest that there is an interaction between central LPS and the histaminergic system where LPS-induced hypophagia is mediated by H1 histamine receptors in 3 h food-deprived broilers.
[Mh] Termos MeSH primário: Regulação do Apetite/efeitos dos fármacos
Galinhas/fisiologia
Comportamento Alimentar/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos/farmacologia
Lipopolissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Clorfeniramina/farmacologia
Famotidina/farmacologia
Privação de Alimentos
Infusões Intraventriculares
Metilistidinas/farmacologia
Piperidinas/farmacologia
Distribuição Aleatória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine Antagonists); 0 (Lipopolysaccharides); 0 (Methylhistidines); 0 (Piperidines); 3U6IO1965U (Chlorpheniramine); 5QZO15J2Z8 (Famotidine); 70050-43-0 (alpha-fluoromethylhistidine); II4319BWUI (thioperamide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160301
[St] Status:MEDLINE
[do] DOI:10.1080/00071668.2016.1141173


  10 / 1185 MEDLINE  
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[PMID]:26916575
[Au] Autor:Castellano I; Migliaccio O; D'Aniello S; Merlino A; Napolitano A; Palumbo A
[Ad] Endereço:Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy.
[Ti] Título:Shedding light on ovothiol biosynthesis in marine metazoans.
[So] Source:Sci Rep;6:21506, 2016 Feb 26.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ovothiol, isolated from marine invertebrate eggs, is considered one of the most powerful antioxidant with potential for drug development. However, its biological functions in marine organisms still represent a matter of debate. In sea urchins, the most accepted view is that ovothiol protects the eggs by the high oxidative burst at fertilization. In this work we address the role of ovothiol during sea urchin development to give new insights on ovothiol biosynthesis in metazoans. The gene involved in ovothiol biosynthesis OvoA was identified in Paracentrotus lividus genome (PlOvoA). PlOvoA embryo expression significantly increased at the pluteus stage and was up-regulated by metals at concentrations mimicking polluted sea-water and by cyclic toxic algal blooms, leading to ovothiol biosynthesis. In silico analyses of the PlOvoA upstream region revealed metal and stress responsive elements. Structural protein models highlighted conserved active site residues likely responsible for ovothiol biosynthesis. Phylogenetic analyses indicated that OvoA evolved in most marine metazoans and was lost in bony vertebrates during the transition from the aquatic to terrestrial environment. These results highlight the crucial role of OvoA in protecting embryos released in seawater from environmental cues, thus allowing the survival under different conditions.
[Mh] Termos MeSH primário: Embrião não Mamífero/enzimologia
Regulação da Expressão Gênica no Desenvolvimento
Metilistidinas/metabolismo
Paracentrotus/enzimologia
Peptídeo Sintases/genética
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Embrião não Mamífero/fisiologia
Metais
Paracentrotus/embriologia
Paracentrotus/fisiologia
Peptídeo Sintases/química
Peptídeo Sintases/metabolismo
Filogenia
Estrutura Terciária de Proteína
Elementos de Resposta
Alinhamento de Sequência
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Metals); 0 (Methylhistidines); 108418-13-9 (ovothiol A); EC 6.3.2.- (Peptide Synthases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160227
[St] Status:MEDLINE
[do] DOI:10.1038/srep21506



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