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[PMID]:29351549
[Au] Autor:García-Ruiz E; Loureiro Í; Farinós GP; Gómez P; Gutiérrez E; Sánchez FJ; Escorial MC; Ortego F; Chueca MC; Castañera P
[Ad] Endereço:Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Departamento de Protección Vegetal, Laboratorio de Malherbología, Madrid, Spain.
[Ti] Título:Weeds and ground-dwelling predators' response to two different weed management systems in glyphosate-tolerant cotton: A farm-scale study.
[So] Source:PLoS One;13(1):e0191408, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of glyphosate, as a post-emergence broad-spectrum herbicide in genetically modified glyphosate-tolerant (GT) cotton, supposes a big change in weed management programs with respect to a conventional regime. Thus, alterations in arable flora and arthropod fauna must be considered when evaluating their potential impacts. A 3-year farm-scale study was conducted in a 2-ha GT cotton crop, in southern Spain, to compare the effects of conventional and glyphosate herbicide regimes on weed abundance and diversity and their consequences for ground-dwelling predators. Surveys reveal that weed density was relatively low within all treatments with a few dominant species, with significantly higher weed densities and modifications of the floristic composition in glyphosate-treated plots that led to an increase in the abundance of Portulaca oleracea and to a reduction in plant diversity. The activity-density of the main predatory arthropod taxa (spiders, ground beetles, rove beetles and earwigs) varied among years, but no significant differences were obtained between conventional and glyphosate herbicide regimes. However, significant differences between treatments were obtained for ground beetles species richness and diversity, being higher under the glyphosate herbicide regime, and a positive correlation with weed density could be established for both parameters. The implications of these findings to weed control in GT cotton are discussed.
[Mh] Termos MeSH primário: Glicina/análogos & derivados
Gossypium/efeitos dos fármacos
Herbicidas/farmacologia
Plantas Daninhas/efeitos dos fármacos
Controle de Plantas Daninhas/métodos
[Mh] Termos MeSH secundário: Animais
Artrópodes/efeitos dos fármacos
Biodiversidade
Coleópteros/efeitos dos fármacos
Produtos Agrícolas/efeitos dos fármacos
Produtos Agrícolas/genética
Produtos Agrícolas/crescimento & desenvolvimento
Ecossistema
Cadeia Alimentar
Glicina/farmacologia
Gossypium/genética
Gossypium/crescimento & desenvolvimento
Resistência a Herbicidas/genética
Insetos/efeitos dos fármacos
Plantas Geneticamente Modificadas
Espanha
Aranhas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Herbicides); 4632WW1X5A (glyphosate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191408


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[PMID]:29291444
[Au] Autor:Khodadust F; Ahmadpour S; Aligholikhamseh N; Abedi SM; Hosseinimehr SJ
[Ad] Endereço:Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
[Ti] Título:An improved Tc-HYNIC-(Ser) -LTVSPWY peptide with EDDA/tricine as co-ligands for targeting and imaging of HER2 overexpression tumor.
[So] Source:Eur J Med Chem;144:767-773, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Overexpression of human epidermal receptor 2 (HER2) has given the opportunity for targeting and delivering of imaging radiotracers. The aim of this study was to evaluate the Tc-HYNIC-(EDDA/tricine)-(Ser) -LTVSPWY peptide for tumor targeting and imaging of tumor with overexpression of HER2. The HYNIC-(Ser) -LTVSPWY was labeled with Tc in presence of EDDA/tricine mixture as co-ligands. The in vitro and in vivo studies of this radiolabeled peptide were performed for cellular specific binding and tumor targeting. The high radiochemical purity of Tc-HYNIC (EDDA/tricine)-(Ser) -LTVSPWY was obtained to be 99%. It exhibited high stability in normal saline and human serum. In HER2 binding affinity study, a significant reduction in uptake of radiolabeled peptide (7.7 fold) was observed by blocking SKOV-3 cells receptors with unlabeled peptide. The K and B values for this radiolabeled peptide were determined as 3.3 ±â€¯1.0 nM and 2.9 ±â€¯0.3 × 10 CPM/pMol, respectively. Biodistribution study revealed tumor to blood and tumor to muscle ratios about 6.9 and 4 respectively after 4 h. Tumor imaging by gamma camera demonstrated considerable high contrast tumor uptake. This developed Tc-HYNIC-(Ser) -LTVSPWY peptide selectively targeted on HER2 tumor and exhibited a high target uptake combined with acceptable low background activity for tumor imaging in mice. The results of this study and its comparison with another study showed that Tc-HYNIC-(EDDA/tricine)-(Ser) -LTVSPWY is much better than previously reported radiolabeled peptide as Tc-CSSS-LTVSPWY for HER2 overexpression tumor targeting and imaging.
[Mh] Termos MeSH primário: Glicina/análogos & derivados
Neoplasias/diagnóstico
Oligopeptídeos/farmacocinética
Compostos de Organotecnécio/farmacocinética
Receptor ErbB-2/biossíntese
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Feminino
Glicina/química
Glicina/farmacocinética
Seres Humanos
Ligantes
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Nus
Estrutura Molecular
Neoplasias/metabolismo
Neoplasias Experimentais/diagnóstico
Neoplasias Experimentais/metabolismo
Oligopeptídeos/síntese química
Oligopeptídeos/química
Compostos de Organotecnécio/síntese química
Compostos de Organotecnécio/química
Relação Estrutura-Atividade
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 ((99m)Tc-HYNIC-(Ser)3-LTVSPWY); 0 (Ligands); 0 (Oligopeptides); 0 (Organotechnetium Compounds); EC 2.7.10.1 (ERBB2 protein, human); EC 2.7.10.1 (Receptor, ErbB-2); TE7660XO1C (Glycine); W12LH4V8V3 (tricine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:29247931
[Au] Autor:Behrend JE; Rypstra AL
[Ad] Endereço:Department of Biology, Miami University, Oxford, OH 45056, USA.
[Ti] Título:Contact with a glyphosate-based herbicide has long-term effects on the activity and foraging of an agrobiont wolf spider.
[So] Source:Chemosphere;194:714-721, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Animals that live in conventional agroecosystems must cope with a variety of anthropogenic chemicals. Most of the focus of toxicology is on lethality, deformities, or short-term shifts in behavior. However, for animals that succeed in spite of their exposure, it is important to determine if long-term changes are brought on by their experience. We tested the hypothesis that contact with a commercial formulation of a glyphosate-based herbicide would affect the behavior of subsequent instars in the wolf spider, Pardosa milvina, a species that thrives in the agroecosystems of eastern United States. In one experiment, we housed females carrying egg sacs on a surface treated with the herbicide for 7 h. Then we monitored their activity and foraging of the offspring 4 weeks after emergence. We repeated the same tests on adults that had been housed with herbicide during their penultimate stage. In both studies, exposed spiders displayed higher levels of activity and greater capture success than their unexposed counterparts. Exposure of penultimate instar to herbicide had larger effects on the behavior of adult males than adult females. These results suggest that herbicides have the potential to adjust the behavior of individuals in the predator community. Thus, impact on the food web and their positive or negative potential for biological control may extend beyond their role in controlling weeds.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Glicina/análogos & derivados
Herbicidas/farmacologia
Comportamento Predatório/efeitos dos fármacos
Aranhas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Cadeia Alimentar
Glicina/farmacologia
Masculino
Aranhas/fisiologia
Tempo
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 4632WW1X5A (glyphosate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29177263
[Au] Autor:Cheki M; Gali H
[Ad] Endereço:Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. mohsencheky@gmail.com.
[Ti] Título:Primary radiation dosimetry of a novel PET radiopharmaceutical Ga-NODAGA-glycine in comparison with Tc-DTPA in renal studies.
[So] Source:Hell J Nucl Med;20(3):241-246, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In this study, we tried to estimate human absorbed dose of Ga-NODAGA-glycine as a new potential positron emission tomography (PET) renal agent based on the biodistribution data reported in healthy rats, and compare our estimation with the available absorbed dose data from technetium-99m-diethylenetriaminepentaacetic acid ( Tc-DTPA). SUBJECTS AND METHODS: The medical internal radiation dose (MIRD) formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for various organs in humans. S factor calculated by Monte-Carlo N-particle (MCNP) simulation and also this factor has been taken from the tables presented in MIRD pamphlet No.11. Hence, two radiation absorbed dose were calculated for organs. RESULTS: Our dose prediction shows that an 185MBq injection of gallium-68-1,4,7-triazacyclononane-1-γ-glutamylglycine-4,7-diacetic acid ( Ga-NODAGA-glycine) in humans might result in an estimated absorbed dose of 0.063mGy in the whole body when S factor calculated by MCNP simulation. The highest absorbed doses are observed in kidneys, lungs, spleen, liver, and red marrow with 3.510, 0.453, 0.335, 0.268, and 0.239mGy, respectively. In addition to, the estimated absorbed dose for total body after injection of 185MBq of Ga-NODAGA-glycine is 0.053mGy when S factor has been taken from MIRD pamphlet No.11. The highest absorbed doses are observed in kidneys, lungs, liver, spleen, and red marrow with 3.110, 0.438, 0.209, 0.203, and 0.203mGy, respectively. Comparison between human absorbed dose estimation for Ga-NODAGA-glycine and Tc-DTPA indicated that the absorbed dose of the most organs after injection of Tc-DTPA is higher than the amount after Ga-NODAGA-glycine. CONCLUSION: The results showed that Ga-NODAGA-glycine delivers lower dose to the patients. Also due to its application in PET (which offers higher sensitivity and spatial resolution compared to planar or SPET), Ga-NODAGA-glycine would be a superior choice than Tc-DTPA for renography and impose less radiation doses to patients.
[Mh] Termos MeSH primário: Absorção de Radiação/fisiologia
Complexos de Coordenação/farmacocinética
Glicina/análogos & derivados
Compostos Heterocíclicos com 1 Anel/farmacocinética
Rim/metabolismo
Modelos Biológicos
Tomografia por Emissão de Pósitrons/métodos
Radiometria/métodos
Pentetato de Tecnécio Tc 99m/farmacocinética
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Glicina/farmacocinética
Seres Humanos
Rim/diagnóstico por imagem
Especificidade de Órgãos/fisiologia
Projetos Piloto
Dose de Radiação
Exposição à Radiação/análise
Compostos Radiofarmacêuticos/farmacocinética
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (68Ga-NODAGA-glycine); 0 (Coordination Complexes); 0 (Heterocyclic Compounds, 1-Ring); 0 (Radiopharmaceuticals); TE7660XO1C (Glycine); VW78417PU1 (Technetium Tc 99m Pentetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910609


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[PMID]:29254377
[Au] Autor:Del Vecchio L; Locatelli F
[Ad] Endereço:a Department of Nephrology and Dialysis , A. Manzoni Hospital , Lecco , Italy.
[Ti] Título:Roxadustat in the treatment of anaemia in chronic kidney disease.
[So] Source:Expert Opin Investig Drugs;27(1):125-133, 2018 Jan.
[Is] ISSN:1744-7658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Anaemia is one of the hallmarks of advanced chronic kidney disease (CKD); it correlates with a lower quality of life and increased cardiovascular risk. Currently its management is based on iron and erythropoiesis-stimulating agents (ESAs) therapy. Given safety issues on ESA therapy and excessive iron use, anaemia management is still suboptimal. Areas covered: The inhibitors of the prolyl-hydroxylases domain (PHD) are oral drugs which activate the hypoxia-inducible factors (HIF) and stimulate the production of endogenous erythropoietin. Roxadustat (FG-4592) is a second-generation PHD inhibitor; it is undergoing now phase-III clinical development. Expert opinion: Phase-II clinical trials have shown that roxadustat is effective and save in the short term in either non-dialysis or dialysis CKD patients. Roxadustat is a chemical drug and thus has the potential of being cheaper than traditional ESAs. Given that the peaks of endogenous EPO are much lower than those observed with traditional ESA, it is possible to speculate the roxadustat (and more in general PHD inhibitors) will be safer than ESA on cardiovascular safety end-points. Considering that HIFs are involved in different pathways, with possible promotion of relevant side effects, their safety must be proven in long-term studies.
[Mh] Termos MeSH primário: Anemia/tratamento farmacológico
Glicina/análogos & derivados
Isoquinolinas/uso terapêutico
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Anemia/etiologia
Animais
Doenças Cardiovasculares/etiologia
Doenças Cardiovasculares/prevenção & controle
Eritropoetina/metabolismo
Glicina/efeitos adversos
Glicina/farmacologia
Glicina/uso terapêutico
Hematínicos/efeitos adversos
Hematínicos/uso terapêutico
Seres Humanos
Isoquinolinas/efeitos adversos
Isoquinolinas/farmacologia
Inibidores de Prolil-Hidrolase/efeitos adversos
Inibidores de Prolil-Hidrolase/farmacologia
Inibidores de Prolil-Hidrolase/uso terapêutico
Qualidade de Vida
Diálise Renal
Insuficiência Renal Crônica/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FG-4592); 0 (Hematinics); 0 (Isoquinolines); 0 (Prolyl-Hydroxylase Inhibitors); 11096-26-7 (Erythropoietin); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1080/13543784.2018.1417386


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[PMID]:29262987
[Au] Autor:Shirai J; Tomata Y; Kono M; Ochida A; Fukase Y; Sato A; Masada S; Kawamoto T; Yonemori K; Koyama R; Nakagawa H; Nakayama M; Uga K; Shibata A; Koga K; Okui T; Shirasaki M; Skene R; Sang B; Hoffman I; Lane W; Fujitani Y; Yamasaki M; Yamamoto S
[Ad] Endereço:Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., Shonan Research Center, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: junya.shirai@cardurion.com.
[Ti] Título:Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.
[So] Source:Bioorg Med Chem;26(2):483-500, 2018 01 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered through optimization of a high-throughput screen hit 1. (R)-N-(2-((3,5-Difluoro-4-(trimethylsilyl)phenyl) amino)-1-(4-methoxyphenyl)-2-oxoethyl)-3-hydroxy-N-methylisoxazole-5-carboxamide (22) was identified as one of the best of these compounds. It displayed higher subtype selectivity and specificity over other nuclear receptors and demonstrated in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD (pharmacodynamic) model upon oral administration.
[Mh] Termos MeSH primário: Descoberta de Drogas
Glicina/análogos & derivados
Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/agonistas
[Mh] Termos MeSH secundário: Administração Oral
Animais
Cristalografia por Raios X
Relação Dose-Resposta a Droga
Glicina/administração & dosagem
Glicina/química
Glicina/farmacologia
Seres Humanos
Células Jurkat
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Modelos Animais
Modelos Moleculares
Estrutura Molecular
Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/genética
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nuclear Receptor Subfamily 1, Group F, Member 3); 0 (phenylglycinamide); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29184921
[Au] Autor:Jaworek MW; Schuabb V; Winter R
[Ad] Endereço:Physical Chemistry I - Biophysical Chemistry, Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany. roland.winter@tu-dortmund.de.
[Ti] Título:The effects of glycine, TMAO and osmolyte mixtures on the pressure dependent enzymatic activity of α-chymotrypsin.
[So] Source:Phys Chem Chem Phys;20(3):1347-1354, 2018 Jan 17.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:High pressure is an important feature of certain natural environments, such as the deep sea where pressures up to about 1000 bar are encountered. Further, pressure effects on biosystems are of increasing interest for biotechnological applications, such as baroenzymology. We studied the effect of two different natural osmolyte mixtures, with major components being glycine and trimethylamine-N-oxide (TMAO), on the activity of α-chymotrypsin, using high-pressure stopped-flow methodology in combination with fast UV/Vis detection. We show that pressure is not only able to drastically enhance the catalytic activity and efficiency of the enzyme, but also that glycine has a significant and diverse effect on the enzymatic activity and volumetric properties of the reaction compared to TMAO. The results might not only help to understand the modulation of enzymatic reactions by natural osmolytes, but also elucidate ways to optimize enzymatic processes in biotechnological applications.
[Mh] Termos MeSH primário: Quimotripsina/metabolismo
Glicina/química
Metilaminas/química
[Mh] Termos MeSH secundário: Quimotripsina/química
Glicina/metabolismo
Hidrólise
Cinética
Metilaminas/metabolismo
Concentração Osmolar
Pressão
Especificidade por Substrato
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylamines); EC 3.4.21.1 (Chymotrypsin); EC 3.4.21.1 (alpha-chymotrypsin); FLD0K1SJ1A (trimethyloxamine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp06042d


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[PMID]:29186342
[Au] Autor:Vandenbeek R; Khan NP; Estall JL
[Ad] Endereço:Institut de recherches cliniques de Montreal, Montreal, Quebec, Canada.
[Ti] Título:Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
[So] Source:Endocrinology;159(2):853-865, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) is a highly conserved transcriptional coactivator enriched in metabolically active tissues including liver, adipose, pancreas, and muscle. It plays a role in regulating whole body energy metabolism and its deregulation has been implicated in type 2 diabetes (T2D). A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of ß cell function. This common polymorphism is within a highly conserved region of the bioactive protein and leads to a single amino acid substitution (glycine 482 to serine). Its prevalence and effects on metabolic parameters appear to vary depending on factors including ethnicity and sex, suggesting important interactions between genetics and cultural/environmental factors and associated disease risk. Interestingly, carriers of the serine allele respond better to some T2D interventions, illustrating the importance of understanding functional impacts of genetic variance on PGC-1α when targeting this pathway for personalized medicine. This review summarizes a growing body of literature surrounding possible links between the PGC-1α Gly482Ser single nucleotide polymorphism and diabetes, with focus on key clinical findings, affected metabolic systems, potential molecular mechanisms, and the influence of geographical or ethnic background on associated risk.
[Mh] Termos MeSH primário: Doenças Metabólicas/genética
Mutação de Sentido Incorreto
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Diabetes Mellitus Tipo 2/genética
Ligação Genética
Predisposição Genética para Doença
Glicina/genética
Seres Humanos
Resistência à Insulina/genética
Obesidade/genética
Serina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (PPARGC1A protein, human); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 452VLY9402 (Serine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00872


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[PMID]:29309108
[Au] Autor:Jovic-Stosic J; Putic V; Perkovic-Vukcevic N; Babic G; Dordevic S; Segrt Z
[Ti] Título:Intravenous lipid emulsion in treatment of cardiocirculatory disturbances caused by glyphosate-surfactant herbicide poisoning.
[So] Source:Vojnosanit Pregl;73(4):390-2, 2016 Apr.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Glyphosate is the first widely used herbicide against weed in genetically modified crops. Though glyphosate itself has a low toxicity, commercial products are more dangerous because of increased toxicity due to surfactants addition. There is no specific antidote for the poisoning with glyphosate-surfactant (Gly-SH). In recent times, the efficacy of intravenous lipid emulsion (ILE) administration for the treatment of acute poisoning caused by Gly- SH has been investigated. Case Report: A 50-year-old man was admitted 3 hours after self-poisoning with herbicide containing glyphosate and polyoxyethyleneamine, as a surfactant. On admission, the patient was in a coma, hypotensive (80/50 mmHg) and without spontaneous breathing. Electrocardiogram showed widecomplex tachycardia, and arterial blood gas (ABG) revealed acidosis (pH 7.07). Conventional treatment included mechanical ventilation, intravenous fluids, bicarbonate and dopamine. As there was no improvement, ILE was started. The patient received 100 mL of 20% Intralipid® bolus followed by infusion of 400 mL over 20 minutes. Prior to expiration of infusion, a gradual rise in blood pressure was noted, and within 2 hours sinus rhythm was restored. Conclusion: This case report suggests that the use of ILE may be an additional option for the treatment of cardiocirculatory disturbances caused by commercial products of glyphosate herbicide.
[Mh] Termos MeSH primário: Emulsões Gordurosas Intravenosas/uso terapêutico
Glicina/análogos & derivados
Herbicidas/envenenamento
Polietilenoglicóis/envenenamento
Taquicardia/induzido quimicamente
Taquicardia/tratamento farmacológico
[Mh] Termos MeSH secundário: Acidose/induzido quimicamente
Acidose/tratamento farmacológico
Eletrocardiografia
Glicina/envenenamento
Seres Humanos
Masculino
Meia-Idade
Tentativa de Suicídio
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fat Emulsions, Intravenous); 0 (Herbicides); 0 (polyoxyethyleneamine); 30IQX730WE (Polyethylene Glycols); 4632WW1X5A (glyphosate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141017020J


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[PMID]:29317320
[Au] Autor:Feng Y; Feng J; Zheng H; Wang W; Chen F; Yu Y; Cui J
[Ad] Endereço:Lab of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an 710069, PR China.
[Ti] Título:Molecular cloning, characterization, and expression analysis of the three cysteine and glycine-rich protein genes in the Chinese fire-bellied newt Cynops orientalis.
[So] Source:Gene;647:226-234, 2018 Mar 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The cysteine- and glycine-rich protein (CRP) family members, including the cysteine- and glycine-rich protein 1 (CSRP1), cysteine- and glycine-rich protein 2 (CSRP2), and the cysteine- and glycine-rich protein 3 (CSRP3), have exhibited various cellular functions during cell development and differentiation. However, the sequences of the three CSRP genes and their functions are still poorly understood in newts. In this study, we cloned the complete open reading frame (ORF) sequences of the three CSRP genes from the Chinese fire-bellied newt, Cynops orientalis (C. orientalis). The complete ORF sequences of Co-CSRP1, Co-CSRP2, and Co-CSRP3 were 582, 582, and 576bp, respectively, and encoded 193, 193, and 191 amino acids, respectively. The deduced amino acid sequences of the three CRP members showed high similarities with that of other species, particularly, with amphibians. Co-CSRP1 was highly expressed in the kidney, limb, and stomach, however, the expression was low in the spleen, heart, intestine, liver, and tail (P<0.05). The mRNA expression of Co-CSRP2 was higher in the kidney and heart than that in other organs (P<0.05). It was observed that Co-CSRP3 was only expressed in the heart, limb, and tail. The mRNA expression of Co-CSRP1 and Co-CSRP3 was lower in the digits in comparison to other limb segments. However, there was no significant difference of Co-CSRP2 mRNA expression in the four limb segments. The Co-CSRP1 and Co-CSRP2 mRNA expressions were significantly increased, whereas the expression of Co-CSRP3 was remarkably decreased during the limb regeneration. This study will provide useful information for further elucidating the role of Co-CSRP genes during newt limb regeneration.
[Mh] Termos MeSH primário: Proteínas Nucleares/genética
Salamandridae/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência de Bases
Clonagem Molecular/métodos
Cisteína/genética
Glicina/genética
Alinhamento de Sequência
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nuclear Proteins); K848JZ4886 (Cysteine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE



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