Base de dados : MEDLINE
Pesquisa : D12.644.276.374.465.186 [Categoria DeCS]
Referências encontradas : 21406 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2141 ir para página                         

  1 / 21406 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29372577
[Au] Autor:Mansouri F; Heydarzadeh R; Yousefi S
[Ad] Endereço:Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
[Ti] Título:The association of interferon-gamma, interleukin-4 and interleukin-17 single-nucleotide polymorphisms with susceptibility to tuberculosis.
[So] Source:APMIS;126(3):227-233, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Susceptibility to tuberculosis and progression of the disease depend on interactions between the bacterial agent, host immune system, and environmental and genetic factors. In this case-controlled study, we aimed to determine the role of single-nucleotide polymorphisms of interferon-gamma, interleukin-4 and interleukin-17 in susceptibility to tuberculosis. Genomic DNA was extracted from peripheral blood samples of patients and controls. The association of single-nucleotide polymorphisms in interleukin-4 (-590C/T), interleukin-17 (-152A/G) and interferon-gamma (+874T/A) was investigated by polymerase chain reaction (PCR)-restriction fragment length polymorphism and amplification refractory mutation system-PCR. A total of 76 tuberculosis patients and 119 healthy individuals were included in this study. The interferon-gamma (+874T/A) TA genotype was significantly associated with susceptibility to tuberculosis in patients compared to controls (OR = 1.76; 95%CI = 0.84-3.71; p = 0.007), while the interferon-gamma (+874T/A) TT genotype (OR = 0.51; 95%CI = 0.19-1.36; p = 0.007) had protective effects against tuberculosis and was related to a low risk of tuberculosis development. The difference between allelic and genotypic frequencies of interleukin-4 (-590C/T) between patients and controls was not significant (p = 0.46). Multivariate logistic regression analysis revealed that the interleukin-17 (-152A/G) AG genotype (OR = 2.27; 95%CI = 1.19-4.34; p = 0.03) and AA genotype (OR = 1.03; 95%CI = 0.43-2.44; p = 0.03) were significantly different between patients and controls. In conclusion, single-nucleotide mutations in different cytokine genes may have protective effects or increase the risk of tuberculosis.
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Interferon gama/genética
Interleucina-17/genética
Interleucina-4/genética
Tuberculose Pulmonar/genética
[Mh] Termos MeSH secundário: Adulto
Alelos
Estudos de Casos e Controles
DNA/genética
Feminino
Frequência do Gene/genética
Genótipo
Seres Humanos
Masculino
Meia-Idade
Mycobacterium tuberculosis/imunologia
Técnicas de Amplificação de Ácido Nucleico
Polimorfismo de Fragmento de Restrição
Polimorfismo de Nucleotídeo Único/genética
Tuberculose Pulmonar/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL17A protein, human); 0 (IL4 protein, human); 0 (Interleukin-17); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); 9007-49-2 (DNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12810


  2 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29458538
[Au] Autor:Ma J; Yu L; Song B; Yu Y; Zhang S; Wei Y; Wu Z; Yao D; Yu W; Zhu Z; Cui Y
[Ad] Endereço:1​College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, PR China.
[Ti] Título:The double adjuvants LTB and CpG significantly enhanced the immuno-protective effects of recombinant GIT derived from Staphylococcus aureus and Streptococcus in mice.
[So] Source:J Med Microbiol;67(3):432-440, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In this study, we prepared GapC1-150-IsdB126-361-TRAP (GIT) proteins plus heat-labile enterotoxin B (LTB) as an intra-molecular adjuvant, together with CpG to further enhance its immunogenicity. METHODOLOGY: Initially, the target genes were acquired and inserted into pET-32a (+) vectors to express LTB-GIT protein. LTB-GIT expression was confirmed by Western blotting and its immunocompetence was estimated through ELISA. Further, we immunized BALB/c mice with the LTB-GIT plus CpG adjuvant. After the second immunization, the antigen-specific CD4 cell responses for IFN-γ, IL-2, IL-4 and IL-10 were monitored by intracellular cytokine staining (ICS) assay. After the third immunization, the level of IgG antibodies in the serum from immunized groups was assessed by ELISA, and the protective immune response was appraised by Staphylococcus aureus and Streptococcus dysgalactiae challenge. RESULTS: The ELISA results showed that the OD450nm value of the LTB-GIT group was significantly higher than that of the BSA group. The group immunized with LTB-GIT plus CpG exhibited significantly stronger CD4 T cell responses for IFN-γ, IL-2, IL-4 and IL-10 compared to the group immunized with LTB-GIT, GIT alone orLTB-GIT plus CpG. In addition, the group immunized with LTB-GIT plus CpG generated the highest level of IgG antibodies against GIT among all of the groups, and our results also showed that LTB-GIT plus CpG markedly improved the survival percentage of mice compared to other groups. CONCLUSION: We confirmed that the novel double adjuvants, LTB and CpG, are able to significantly improve GIT-induced immune responses. This formula could be a promising strategy for enhancing the immune efficacy of multi-subunit vaccines against Staphylococcus aureus and streptococcal infection.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos
Toxinas Bacterianas/imunologia
Vacinas Bacterianas/imunologia
Enterotoxinas/imunologia
Oligodesoxirribonucleotídeos/imunologia
Staphylococcus aureus/imunologia
Streptococcus/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/imunologia
Proteínas de Bactérias/imunologia
Toxinas Bacterianas/administração & dosagem
Toxinas Bacterianas/genética
Linfócitos T CD4-Positivos
Enterotoxinas/administração & dosagem
Enterotoxinas/genética
Feminino
Interferon gama/imunologia
Interleucina-10/imunologia
Interleucina-2/imunologia
Interleucina-4/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Oligodesoxirribonucleotídeos/genética
Proteínas Recombinantes/genética
Proteínas Recombinantes/imunologia
Infecções Estafilocócicas/imunologia
Staphylococcus aureus/química
Infecções Estreptocócicas/imunologia
Streptococcus/química
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antibodies, Bacterial); 0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (Bacterial Toxins); 0 (Bacterial Vaccines); 0 (CPG-oligonucleotide); 0 (Enterotoxins); 0 (IL10 protein, mouse); 0 (Interleukin-2); 0 (Oligodeoxyribonucleotides); 0 (Recombinant Proteins); 130068-27-8 (Interleukin-10); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000666


  3 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29203739
[Au] Autor:Berezniakova AI; Cheremisina VF
[Ad] Endereço:National Pharmaceutical University, Kharkov, Ukraine.
[Ti] Título:4 and 6 interleukin's action in the pathogenesis of periodontitis, gingivitis and dental alveolitis.
[So] Source:Wiad Lek;70(5):910-912, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The paper presents the results of studying the role of interleukins 4 and 6 in the pathogenesis of periodontal tissue diseases, specifically, in periodontitis, gingivitis and alveolitis. THE AIM: To study the nature of participation of IL-4 and IL-6 in the mechanisms of development of periodontitis, gingivitis and alveolitis. MATERIALS AND METHODS: Studies were carried out on 80 nonlinear male rats with a body weight of 200.0 to 220.0 g divided into four groups of 20 animals each. The serum level of cytokines was determined by an enzyme immunoassay on the Multiscane Biotech analyzer using test systems manufactured by Caltag laboratories (USA). Statistical processing of the obtained digital results was processed with the help of the program "Statistica 8.0". Indicators of the reliability of changes between the control and intact groups also used the Student's test and the Excel program. The confidence level was taken at p <0.05. RESULTS: As a result of our experiments, noticeable changes in the anti-inflammatory cytokine IL-4 were observed in rats with experimental periodontitis. The level of IL-4 cytokine in rats with alveolitis did not differ from control. The level of proinflammatory cytokine IL-6 from all groups of animals with periodontal disease differed from control only in rats with gingivitis, where it decreased by 74% and its level became less with alveolitis and periodontitis, since in these diseases the level of IL-6 was practically the same from the control (p <0,05). We also succeeded in revealing that at a low level of profibrogenic IL-6, there is not enough stimulation of collagen synthesis in the periodontal bone tissue. The increased level of IL-4 in a group of animals with gingivitis, on the contrary, indicates the realization of a pathological reaction of the organism. CONCLUSIONS: The change in the levels of pro- and anti-inflammatory interleukins, especially with gingivitis, indicates a decrease in the body's adaptive reserves and may affect the further dynamics of the inflammatory process in the periodontal tissues.
[Mh] Termos MeSH primário: Processo Alveolar/imunologia
Gengivite/imunologia
Interleucina-4/sangue
Interleucina-6/sangue
Doenças Periodontais/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Técnicas Imunoenzimáticas
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 207137-56-2 (Interleukin-4)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  4 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28458470
[Au] Autor:Dowal L; Parameswaran P; Phat S; Akella S; Majumdar ID; Ranjan J; Shah C; Mogre S; Guntur K; Thapa K; Gesta S; Vishnudas VK; Narain NR; Sarangarajan R
[Ad] Endereço:Berg LLC, Framingham, MA, USA.
[Ti] Título:Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses.
[So] Source:Mediators Inflamm;2017:9067049, 2017.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptional regulation of , , , and and their level of IL-6 secretion. The inflammatory profile of PMA-differentiated U937 and THP-1 macrophages, in resting state and after stimulation with LPS/IFN-gamma and IL-4, was assessed by measuring IL-6 secretion and transcriptional regulation of a panel of inflammatory genes after mono- or indirect coculture with white and brown adipocytes. White adipocyte monocultures show increased IL-6 secretion compared to brown adipocytes. White adipocytes cocultured with U937 and THP-1 macrophages induced a greater increase in IL-6 secretion compared to brown adipocytes cocultured with both macrophages. White adipocytes cocultured with macrophages increased inflammatory gene expression in both types. In contrast, macrophages cocultured with brown adipocytes induced downregulation or no alterations in inflammatory gene expression. The effects of adipocytes on macrophages appear to be independent of stimulation state. Brown adipocytes exhibit an intrinsic ability to dampen inflammatory profile of macrophages, while white adipocytes enhance it. These data suggest that brown adipocytes may be less prone to adipose tissue inflammation that is associated with obesity.
[Mh] Termos MeSH primário: Adipócitos Marrons/metabolismo
Adipócitos Brancos/metabolismo
Inflamação/metabolismo
Macrófagos/metabolismo
[Mh] Termos MeSH secundário: Adipócitos Marrons/efeitos dos fármacos
Adipócitos Marrons/imunologia
Adipócitos Brancos/efeitos dos fármacos
Adipócitos Brancos/imunologia
Adulto
Diferenciação Celular/efeitos dos fármacos
Linhagem Celular
Células Cultivadas
Ensaio de Imunoadsorção Enzimática
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Inflamação/imunologia
Interleucina-4/farmacologia
Interleucina-6/metabolismo
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Lipopolysaccharides); 207137-56-2 (Interleukin-4)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1155/2017/9067049


  5 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28459437
[Au] Autor:Toussaint M; Jackson DJ; Swieboda D; Guedán A; Tsourouktsoglou TD; Ching YM; Radermecker C; Makrinioti H; Aniscenko J; Bartlett NW; Edwards MR; Solari R; Farnir F; Papayannopoulos V; Bureau F; Marichal T; Johnston SL
[Ad] Endereço:Airway Disease Infection Section, National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
[Ti] Título:Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
[So] Source:Nat Med;23(6):681-691, 2017 06.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
[Mh] Termos MeSH primário: Asma/imunologia
Citocinas/imunologia
DNA/imunologia
Armadilhas Extracelulares/imunologia
Infecções por Picornaviridae/imunologia
Hipersensibilidade Respiratória/imunologia
Infecções Respiratórias/imunologia
Células Th2/imunologia
[Mh] Termos MeSH secundário: Adulto
Animais
Estudos de Casos e Controles
Dermatophagoides farinae/imunologia
Modelos Animais de Doenças
Feminino
Seres Humanos
Interferon gama/imunologia
Interleucina-13/imunologia
Interleucina-4/imunologia
Interleucina-5/imunologia
Masculino
Camundongos
Meia-Idade
Rhinovirus
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Interleukin-13); 0 (Interleukin-5); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4332


  6 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29198882
[Au] Autor:Sekiguchi K; Ogawa E; Kurohane K; Konishi H; Mochizuki N; Manabe K; Imai Y
[Ad] Endereço:Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City, Shizuoka 422-8526, Japan.
[Ti] Título:Adjuvant effect of short chain triacylglycerol tributyrin on a mouse contact hypersensitivity model.
[So] Source:Toxicol Lett;284:56-62, 2018 Mar 01.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Little attention has been paid to chemicals that can enhance hypersensitivity caused by other chemicals. We have demonstrated that phthalate esters with short chain alcohols enhance fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) in a mouse model. Furthermore, phthalate esters with such an enhancing effect were found to activate transient receptor potential ankyrin 1 (TRPA1) cation channels, which are expressed on a part of sensory neurons, using a TRPA1-expressing cell line. In this study, we examined these activities of esters comprising glycerol and a short chain fatty acid, i.e. dibutyrin and tributyrin. We carried out chemical synthesis of dibutyrin isomers. Each dibutyrin isomer weakly activated TRPA1 and slightly enhanced skin sensitization to FITC. Unexpectedly, TRPA1 activation and enhancement of FITC-CHS were much more evident in the presence of tributyrin. Mechanistically, tributyrin induced increased dendritic cell trafficking from the skin to draining lymph nodes. Tributyrin enhanced interferon-γ (IFN-γ) production by draining lymph nodes, while its effect on interleukin-4 (IL-4) production was relatively less prominent. These results suggested that tributyrin concomitantly caused TRPA1 activation and an adjuvant effect on FITC-CHS.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/toxicidade
Dermatite de Contato/imunologia
Canal de Cátion TRPA1/metabolismo
Triglicerídeos/toxicidade
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/administração & dosagem
Animais
Células CHO
Movimento Celular/efeitos dos fármacos
Cricetulus
Células Dendríticas/efeitos dos fármacos
Dermatite de Contato/metabolismo
Modelos Animais de Doenças
Feminino
Fluoresceína-5-Isotiocianato/administração & dosagem
Fluoresceína-5-Isotiocianato/toxicidade
Seres Humanos
Interferon gama/metabolismo
Interleucina-4/metabolismo
Linfonodos/efeitos dos fármacos
Linfonodos/imunologia
Camundongos Endogâmicos BALB C
Pele/efeitos dos fármacos
Pele/imunologia
Triglicerídeos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (TRPA1 Cation Channel); 0 (Triglycerides); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); I223NX31W9 (Fluorescein-5-isothiocyanate); S05LZ624MF (tributyrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  7 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29353040
[Au] Autor:Jung Y; Kim JC; Park NJ; Bong SK; Lee S; Jegal H; Jin LT; Kim SM; Kim YK; Kim SN
[Ad] Endereço:Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Gangwon-do 25451, Republic of Korea.
[Ti] Título:Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice.
[So] Source:Biochem Biophys Res Commun;496(2):508-514, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor α (PPARα) in a keratinocyte cell line and acts as an agonist of PPARα. PPARα agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function. In this study, we confirmed that the effects of eupatilin improved AD-like symptoms in an oxazolone-induced AD-like mouse model. Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), IL-1ß, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model. Taken together, our data suggest that eupatilin is a potential candidate for the treatment of AD.
[Mh] Termos MeSH primário: Dermatite Atópica/tratamento farmacológico
Fármacos Dermatológicos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Flavonoides/farmacologia
PPAR alfa/genética
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Citocinas/genética
Citocinas/imunologia
Dermatite Atópica/induzido quimicamente
Dermatite Atópica/imunologia
Dermatite Atópica/patologia
Relação Dose-Resposta a Droga
Feminino
Regulação da Expressão Gênica
Imunoglobulina E/sangue
Imunoglobulina E/genética
Interferon gama/genética
Interferon gama/imunologia
Interleucina-1beta/genética
Interleucina-1beta/imunologia
Interleucina-33/genética
Interleucina-33/imunologia
Interleucina-4/genética
Interleucina-4/imunologia
Interleucinas/genética
Interleucinas/imunologia
Proteínas de Filamentos Intermediários/genética
Proteínas de Filamentos Intermediários/imunologia
Proteínas de Membrana/genética
Proteínas de Membrana/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Oxazolona
PPAR alfa/imunologia
Ratos
Transdução de Sinais
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (D17Wsu104e protein, mouse); 0 (Dermatologic Agents); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (IL1B protein, mouse); 0 (Il33 protein, mouse); 0 (Interleukin-1beta); 0 (Interleukin-33); 0 (Interleukins); 0 (Intermediate Filament Proteins); 0 (Membrane Proteins); 0 (PPAR alpha); 0 (Tumor Necrosis Factor-alpha); 0 (filaggrin); 0 (loricrin); 0 (thymic stromal lymphopoietin); 15646-46-5 (Oxazolone); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); 4D58O05490 (eupatilin); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180122
[St] Status:MEDLINE


  8 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29262348
[Au] Autor:Sander J; Schmidt SV; Cirovic B; McGovern N; Papantonopoulou O; Hardt AL; Aschenbrenner AC; Kreer C; Quast T; Xu AM; Schmidleithner LM; Theis H; Thi Huong LD; Sumatoh HRB; Lauterbach MAR; Schulte-Schrepping J; Günther P; Xue J; Baßler K; Ulas T; Klee K; Katzmarski N; Herresthal S; Krebs W; Martin B; Latz E; Händler K; Kraut M; Kolanus W; Beyer M; Falk CS; Wiegmann B; Burgdorf S; Melosh NA; Newell EW; Ginhoux F; Schlitzer A; Schultze JL
[Ad] Endereço:Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115 Bonn, Germany.
[Ti] Título:Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
[So] Source:Immunity;47(6):1051-1066.e12, 2017 Dec 19.
[Is] ISSN:1097-4180
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, and heterogeneity remains largely unknown, hampering their clinical use. High-dimensional techniques were used to elucidate transcriptional, phenotypic, and functional differences between human in vivo and in vitro generated mononuclear phagocytes to facilitate their full potential in the clinic. We demonstrate that monocytes differentiated by macrophage colony-stimulating factor (M-CSF) or granulocyte macrophage colony-stimulating factor (GM-CSF) resembled in vivo inflammatory macrophages, while moDCs resembled in vivo inflammatory DCs. Moreover, differentiated monocytes presented with profound transcriptomic, phenotypic, and functional differences. Monocytes integrated GM-CSF and IL-4 stimulation combinatorically and temporally, resulting in a mode- and time-dependent differentiation relying on NCOR2. Finally, moDCs are phenotypically heterogeneous and therefore necessitate the use of high-dimensional phenotyping to open new possibilities for better clinical tailoring of these cellular therapies.
[Mh] Termos MeSH primário: Células Dendríticas/imunologia
Interleucina-4/imunologia
Macrófagos/imunologia
Monócitos/imunologia
Correpressor 2 de Receptor Nuclear/imunologia
Transdução de Sinais/imunologia
[Mh] Termos MeSH secundário: Diferenciação Celular
Linhagem da Célula
Células Dendríticas/citologia
Células Dendríticas/efeitos dos fármacos
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Fator Estimulador de Colônias de Granulócitos e Macrófagos/farmacologia
Seres Humanos
Imunofenotipagem
Interleucina-4/genética
Interleucina-4/farmacologia
Ativação de Macrófagos
Fator Estimulador de Colônias de Macrófagos/farmacologia
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Monócitos/citologia
Monócitos/efeitos dos fármacos
Correpressor 2 de Receptor Nuclear/genética
Cultura Primária de Células
Fatores de Tempo
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL4 protein, human); 0 (NCOR2 protein, human); 0 (Nuclear Receptor Co-Repressor 2); 207137-56-2 (Interleukin-4); 81627-83-0 (Macrophage Colony-Stimulating Factor); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


  9 / 21406 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29262451
[Au] Autor:Chen XQ; Ma Q; Zhou LY; Ma HA; Wu JY; Zhao JJ; Yan DN
[Ad] Endereço:Department of Otorhinolaryngology, Affiliated Hospital of Nanjing University of TCM, Nanjing 210029, China.
[Ti] Título:[Experimental study on the effect of Yiqi Wenyang Decoction on nasal mucosa infiltration of NK cells in mice with allergic rhinitis].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(12):921-926, 2017 Dec 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To observe the effect of Yiqi Wenyang Decoction on the infiltration and activation of NK cells in nasal mucosa of mouse model with allergic rhinitis (AR), and to explore the potential mechanism for effective intervention of AR with Yiqi Wenyang Decoction. Fourty-eight mice were randomly divided into blank group, model group, low, medium and high dose of Yiqi Wenyang Decoction group and Cetirizine group, with 8 rats in each group. After modeling of AR, the model group was filled with 0.9% sodium chloride solution. Yiqi Wenyang Decoction groups of each dose were given different concentrations of Yiqi Wenyang Decoction water extract, while the Cetirizine group was given aqueous solution of Cetirizine. The behavior, morphological changes of nasal mucosa and infiltration of NK cells in nasal mucosa were observed. The levels of IL-4 and INF-γ in nasal lavage fluid were measured. Besides, the drug safety was observed by acute toxicity test. In the respect of behavioral scoring, middle and high dose of Yiqi Wenyang Decoction group were superior to the model group (number of sneezing: value was 7.189, 8.748, respectively; number of scratching nose: value was 12.074, 14.560, respectively; all <0.05). In middle and high dose of Yiqi Wenyang Decoction group, the infiltration of NK cells and nasal lavage fluid IL-4 levels were lower than those in model group (IOD: value was 10.073, 12.322, respectively; IOD/Area: value was 10.954, 14.073, respectively; IL-4: value was 4.705, 6.801, respectively; all <0.05). There was no significant difference in nasal lavage fluid of INF-γ among each group ( =1.166, >0.05). In acute toxicity test, no obvious poisoning symptoms and death occurred in mice. Yiqi Wenyang Decoction can control the nasal symptom, reduce the local NK cell infiltration of nasal mucosa and inhibit the expression of the 2-type cytokines released by NK cells, which may be related with the potential mechanism of effective intervention of AR with Yiqi Wenyang Decoction.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Células Matadoras Naturais/efeitos dos fármacos
Rinite Alérgica/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antialérgicos/efeitos adversos
Antialérgicos/uso terapêutico
Cetirizina/efeitos adversos
Cetirizina/uso terapêutico
Modelos Animais de Doenças
Medicamentos de Ervas Chinesas/efeitos adversos
Interferon gama/análise
Interleucina-4/análise
Camundongos
Líquido da Lavagem Nasal/química
Mucosa Nasal/citologia
Mucosa Nasal/imunologia
Distribuição Aleatória
Rinite Alérgica/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Drugs, Chinese Herbal); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); YO7261ME24 (Cetirizine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2017.12.009


  10 / 21406 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:29244929
[Au] Autor:Osikov MV; Ogneva OI
[Ti] Título:Relationship between the change of ethological status and concentration of certain cytokines in blood in experimental desynchronosis under led lighting.
[So] Source:Patol Fiziol Eksp Ter;60(4):93-100, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Changing the natural rhythm of day and night leads to the development of DS, disruption of coordinated muscular activity, adequate behavioral activity, a decrease of attention in the performance of night work by experts in various fields. Changes ethological status may potentiate or weaken the changes in the indices of immune status, contribute to the formation of allostatic load at desynchronosis. The purpose: To investigate the relationship between changes ethological status and concentration of certain cytokines in peripheral blood in experimental desynchronosis under LED lighting. Methods: The study was performed on 158 adult guinea pigs, which were randomly assigned into 2 groups: 1 group- animals in the conditions of standard fixed (12 h light / 12 h dark) LED lighting (SFSDO); 2 group- animals with jet lag in terms of LED lighting (DESSDO). Light desynchronosis created by keeping animals at clock coverage for 30 days. Behavioral activity was studied in the test «open field¼ cognitive function was assessed using aqueous «labyrinth¼ Morris. By ELISA was determined on the apparatus in the peripheral blood concentration of interleukin - 4 (IL-4), interferon-gamma (IFN-g), melatonin, cortisol via specific for guinea pig test systems. Results: It was found that in animals of DS in terms of LED lighting in the dynamics of 10-30 days of observation show signs of anxiety, depression orienting-exploratory behavior, reduce the long-term memory and learning ability, spatial orientation disorders. It found that when a jet lag LED lighting conditions for 10 days, 20 days and 30 days in peripheral blood melatonin concentration decreases, the concentration of cortisol rises. In peripheral blood decreased IL-4 concentrations of 20 and 30 days, reducing the concentration of IFN-g at 30 days. Based on the results of correlation analysis, ethological change status and progress of cognitive function with a decrease in the blood concentration of IL-4 and IFN-g, the concentration of melatonin increase cortisol levels. Conclusion: The results indicate that in experimental conditions in desynchronosis LED lighting changes ethological status are associated with the progression of immune status changes.
[Mh] Termos MeSH primário: Transtornos Cronobiológicos/sangue
Interferon gama/sangue
Interleucina-4/sangue
Iluminação
[Mh] Termos MeSH secundário: Animais
Transtornos Cronobiológicos/fisiopatologia
Cobaias
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE



página 1 de 2141 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde