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[PMID]:28450653
[Au] Autor:Soewondo P; Suyono S; Sastrosuwignyo MK; Harahap AR; Sutrisna B; Makmun LH
[Ad] Endereço:Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. soewondops@yahoo.com.
[Ti] Título:Prediction of Wound Healing in Diabetic Foot Ulcers: an Observational Study in Tertiary Hospital in Indonesia.
[So] Source:Acta Med Indones;49(1):41-51, 2017 Jan.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:AIM: to evaluate the role of clinical characteristics, functional markers of vasodilation, inflammatory response, and atherosclerosis in predicting wound healing in diabetic foot ulcer. METHODS: a cohort study (February - October 2010) was conducted from 40 subjects with acute diabetic foot ulcer at clinical ward of Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Each subject underwent at least two variable measurements, i.e. during inflammatory phase and proliferation phase. The studied variables were clinical characteristics, complete peripheral blood count (CBC) and differential count, levels of HbA1c, ureum, creatinine, lipid profile, fasting blood glucose (FBG), marker of endothelial dysfunction (asymmetric dimethylarginine/ADMA, endothelin-1/ET-1, and flow-mediated dilation/FMD of brachial artery), and marker of vascular calcification (osteoprotegerin/OPG). RESULTS: median of time achieving 50% granulation tissue in our study was 21 days. There were nine factors that contribute in the development of 50% granulation tissue, i.e. family history of diabetes mellitus (DM), previous history of wound, wound area, duration of existing wound, captopril and simvastatin medications, levels of ADMA, ET-1, and OPG. There were three out of the nine factors that significantly correlated with wound healing, i.e. wound area, OPG levels, and simvastatin medications. CONCLUSION: in acute diabetic foot ulcers, wound area and OPG levels had positive correlation with wound healing, whereas simvastatin medications had negative correlation with wound healing.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/complicações
Pé Diabético/sangue
Osteoprotegerina/sangue
Calcificação Vascular/sangue
Cicatrização
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Estudos de Coortes
Endotelina-1/sangue
Feminino
Seres Humanos
Indonésia
Estimativa de Kaplan-Meier
Modelos Lineares
Masculino
Meia-Idade
Análise Multivariada
Centros de Atenção Terciária
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Endothelin-1); 0 (Osteoprotegerin); 0 (TNFRSF11B protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  2 / 11640 MEDLINE  
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[PMID]:29390406
[Au] Autor:Zhang CL; Xie S; Qiao X; An YM; Zhang Y; Li L; Guo XB; Zhang FC; Wu LL
[Ad] Endereço:Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Ministry of Education.
[Ti] Título:Plasma endothelin-1-related peptides as the prognostic biomarkers for heart failure: A PRISMA-compliant meta-analysis.
[So] Source:Medicine (Baltimore);96(50):e9342, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Most studies reported that high plasma endothelin-1 (ET-1), big ET-1, and C-terminal proET-1 (CT-proET-1) were correlated with poor prognosis of heart failure (HF). However, available evidence remains controversial. To help solve the debate, we collected all the available studies and performed a meta-analysis. METHODS: We searched the databases covering Embase, PubMed, Ovid, and Web of Science on June 28, 2017. The hazard ratio (HR) or risk ratio (RR) and its 95% confidence intervals (CIs) were collected and calculated by use of a random-effect model. Heterogeneity was assessed by Cochran's Q test, and publication bias was assessed by funnel plots with Egger's and Begg's linear regression test. RESULTS: Thirty-two studies with 18,497 patients were included in the analysis. Results showed that circulating ET-1, big ET-1, and CT-proET-1 were positively correlated with high risk of adverse outcomes, with pooled RRs (95% CIs) of 2.22 (1.82-2.71, P < .001), 2.47 (1.93-3.17, P < .001), and 2.27 (1.57-3.29, P < .001), respectively. In the subgroup of death as primary outcome, the pooled RRs (95% CIs) were 2.13 (1.68-2.70, P < .001), 2.55 (1.82-3.57, P < .001), and 2.02 (1.39-2.92, P < .001) for ET-1, big ET-1, and CT-proET-1, respectively. No significant publication bias was observed in this study. CONCLUSION: Our meta-analysis provided evidence that increased plasma levels of ET-1, big ET-1, and CT-proET-1 were associated with poor prognosis or mortality for HF populations.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Endotelina-1/sangue
Insuficiência Cardíaca/sangue
[Mh] Termos MeSH secundário: Seres Humanos
Fragmentos de Peptídeos/sangue
Prognóstico
Precursores de Proteínas/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Biomarkers); 0 (Endothelin-1); 0 (Peptide Fragments); 0 (Protein Precursors); 0 (proendothelin 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009342


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[PMID]:29441924
[Au] Autor:Zhou C; Guo X; Cui Q; Liu X; Su G; Zhang J
[Ti] Título:Sildenafil improves the function of endothelial cells in patients suffering from congenital heart disease with pulmonary hypertension.
[So] Source:Pharmazie;71(10):570-574, 2016 Oct 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aim of this study was to investigate the potential effects of sildenafil on the function of endothelial cells from patients with congenital heart disease with pulmonary hypertension (CHDPH). Patients who are diagnosed as CHD with PH (n=30) or without PH (n=30), and 30 healthy persons (control) were enrolled in this study. The 30 CHDPH cases were separated into two groups, one was given aspirin while the other received aspirin and sildenafil. An ELISA assay was used to detect the biological indexes for endothelial cells. Furthermore, 24 male New Zealand white rabbits were used to construct the CHDPH model. The signal pathway-related protein expression was analyzed using RT-PCR and western blotting. Compared to that in healthy people, levels for flowmediated dilatation (FDM), NO, and adiponectin (APN) were significantly decreased while endothelin (ET-1) was significantly increased in CHD patients, while their levels were drastically changed in CHDPH patients (P<0.01). Besides, no significant differences for expression levels including FDM, APN, NO, and ET-1 was observed in CHDPH patients receiving aspirin. But the levels for FDM, APN, NO, and ET-1 were significantly changed in CHDPH patients after treatment with sildenafil for 3 months (P<0.01). The mRNA and protein levels for JNK1/2, MAPK, and NF-κB were significantly increased in CHDPH rabbits compared to the control (P<0.01), but their levels were significantly suppressed by the sildenafil application compared to the CHDPH group (P<0.01). Taken together, our study suggested that sildenafil may play a protective role on endothelial function via suppressing the JNK and NF-κB signal pathways in CHDPH patients.
[Mh] Termos MeSH primário: Células Endoteliais/efeitos dos fármacos
Cardiopatias Congênitas/tratamento farmacológico
Hipertensão Pulmonar/tratamento farmacológico
Citrato de Sildenafila/uso terapêutico
Vasodilatadores/uso terapêutico
[Mh] Termos MeSH secundário: Adiponectina/metabolismo
Animais
Aspirina/uso terapêutico
Endotelina-1/metabolismo
Ensaio de Imunoadsorção Enzimática
Voluntários Saudáveis
Cardiopatias Congênitas/fisiopatologia
Seres Humanos
Hipertensão Pulmonar/fisiopatologia
Masculino
NF-kappa B/efeitos dos fármacos
NF-kappa B/metabolismo
Óxido Nítrico/metabolismo
Inibidores da Agregação de Plaquetas/uso terapêutico
Coelhos
Transdução de Sinais/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (Adiponectin); 0 (Endothelin-1); 0 (NF-kappa B); 0 (Platelet Aggregation Inhibitors); 0 (Vasodilator Agents); 31C4KY9ESH (Nitric Oxide); BW9B0ZE037 (Sildenafil Citrate); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6510


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[PMID]:29351334
[Au] Autor:Chang W; Lajko M; Fawzi AA
[Ad] Endereço:Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States of America.
[Ti] Título:Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes.
[So] Source:PLoS One;13(1):e0191285, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes. METHODS: Membranes were obtained from eyes undergoing pars plana vitrectomy for complicated proliferative diabetic retinopathy or idiopathic epiretinal membrane. Through standard immunohistochemical techniques, we labeled membranes to explore the distribution of endothelin-1 and endothelin receptor B, comparing proliferative diabetic retinopathy and idiopathic epiretinal membranes. In addition, membranes were also labeled with markers for fibroblasts, endothelial, and glial cells and studied with confocal laser scanning microscopy. The intensity of endothelin-1 labeling was quantified using standard image analysis software. RESULTS: Fourteen membranes were included in the analysis, nine from eyes with proliferative diabetic retinopathy and five idiopathic membranes. Flatmount diabetic membranes showed co-localization of endothelin-1 with S100A4 and CD31. Immunohistochemistry and quantitative analysis of cross-sectional membranes showed significantly higher endothelin-1 labeling in proliferative diabetic retinopathy membranes compared to idiopathic membranes (p<0.05). Diabetic membranes showed more elements staining positive for S100A4 compared to idiopathic membranes. CONCLUSION: Epiretinal membrane formation in proliferative diabetic retinopathy involves higher tissue levels of endothelin-1 and fibroblastic activity. Furthermore, endothelin-1, endothelial and fibroblastic staining appear to be correlated, suggestive of endothelial-to-mesenchymal transition in proliferative diabetic retinopathy.
[Mh] Termos MeSH primário: Retinopatia Diabética/metabolismo
Retinopatia Diabética/patologia
Endotelina-1/metabolismo
[Mh] Termos MeSH secundário: Adulto
Proliferação Celular
Feminino
Fibrose
Proteína Glial Fibrilar Ácida/metabolismo
Seres Humanos
Masculino
Membranas/patologia
Meia-Idade
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Retina/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endothelin-1); 0 (Glial Fibrillary Acidic Protein); 0 (Platelet Endothelial Cell Adhesion Molecule-1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191285


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[PMID]:29185789
[Au] Autor:Mou Y; Zhang Y; Guo C; Zhao J; Zhang Z; Zhou X; Dong J; Liao L
[Ad] Endereço:1 Division of Cardiology, Department of Internal Medicine, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
[Ti] Título:Integrated Treatment of Prostaglandin E1 and Angiotensin-Converting Enzyme Inhibitor in Diabetic Kidney Disease Rats: Possible Role of Antiapoptosis in Renal Tubular Epithelial Cells.
[So] Source:DNA Cell Biol;37(2):133-141, 2018 Feb.
[Is] ISSN:1557-7430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate the therapeutic mechanisms underlying prostaglandin E1 (PGE1) and angiotensin-converting enzyme inhibitor (ACEI) on reducing urinary protein in diabetic kidney disease (DKD). DKD rats were established and randomly divided into four groups: PGE1 (10 µg/kg/day) (P group), ACEI (10 mg/kg/day) (A group), combination of PGE1 with ACEI treatment (P + A group), and saline treatment group (DKD group). Untreated rats were used as normal control (N group). Urinary albumin, endothelin-1 (ET-1), angiotensin II (AngII), TUNEL assay, Masson's trichrome staining, and immunohistochemistry staining for CD68 were evaluated in all groups. Ten days after treatment, urinary albumin was significantly decreased in the P and P + A groups (p < 0.01 vs. the DKD group). At the end of 8 weeks, the albumin was still significantly reduced in the P + A group (p < 0.05 vs. the A group). ET-1 and AngII were also significantly decreased in three treatment groups (p < 0.01 vs. the DKD group), especially in the P + A group. Few cells underwent apoptosis in glomerular regions in DKD rats, while amounts of apoptotic cells were seen in tubules regions. Further, apoptosis and the areas of fibrosis in tubulointerstitial were both decreased most in the P + A group compared with the DKD group. Apoptosis of renal tubular epithelial cells may participate in the development and progression of DKD in rats. Combination of PGE1 with AGEI remarkably protects renal function compared with PGE1 or ACEI monotherapy. The potential therapeutic mechanisms of PGE1 and AGEI might be via multiple targets and, at least in part, through inhibiting the apoptosis of renal tubular epithelial cells.
[Mh] Termos MeSH primário: Alprostadil/farmacologia
Inibidores da Enzima Conversora de Angiotensina/farmacologia
Diabetes Mellitus Experimental/complicações
Nefropatias Diabéticas/tratamento farmacológico
Nefrite Intersticial/tratamento farmacológico
[Mh] Termos MeSH secundário: Angiotensina II/sangue
Animais
Apoptose/efeitos dos fármacos
Diabetes Mellitus Experimental/sangue
Nefropatias Diabéticas/sangue
Nefropatias Diabéticas/etiologia
Avaliação Pré-Clínica de Medicamentos
Endotelina-1/sangue
Células Epiteliais/efeitos dos fármacos
Túbulos Renais/efeitos dos fármacos
Túbulos Renais/patologia
Macrófagos/imunologia
Masculino
Nefrite Intersticial/sangue
Nefrite Intersticial/etiologia
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Endothelin-1); 11128-99-7 (Angiotensin II); F5TD010360 (Alprostadil)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1089/dna.2017.3690


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[PMID]:28466542
[Au] Autor:Möckesch B; Connes P; Charlot K; Skinner S; Hardy-Dessources MD; Romana M; Jumet S; Petras M; Divialle-Doumdo L; Martin C; Tressières B; Tarer V; Hue O; Etienne-Julan M; Antoine S; Pialoux V
[Ad] Endereço:Laboratory ACTES (EA 3596), French West Indies University, Pointe-à-Pitre, Guadeloupe, France.
[Ti] Título:Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease.
[So] Source:Br J Haematol;178(3):468-475, 2017 08.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oxidative stress and haemolysis-associated nitric oxide (NO) depletion plays a crucial role in the development of vasculopathy in sickle cell anaemia (SS). However it remains unknown whether oxidative stress and haemolysis levels influence vascular function in patients with sickle haemoglobin C disease (SC). Microvascular response to heat (using Laser Doppler flowmetry on finger), oxidative stress biomarkers, NO metabolites, endothelin-1 and haematological parameters were compared between patients with SS and SC. Vascular function, oxidative and nitrosative markers were also measured in healthy (AA) children. SS and SC had increased plasma advanced oxidation protein products (AOPP), malondialdehyde, plasma antioxidant activities and NO end products, compared to AA. SC had lower catalase activity compared to AA and SS. Haemolytic rate, glutathione peroxidase and nitrotyrosine concentrations were significantly increased in children with SS compared to SC and AA. SS and SC had impaired microvascular reactivity compared to AA. In SS, the plateau phase of the response to local thermal heating was negatively associated with nitrotyrosine and AOPP. No association between vascular function parameters and oxidative stress markers was observed in SC. Mild haemolysis in SC, compared to SS, may limit oxidative and nitrosative stress and could explain the better preserved microvascular function in this group.
[Mh] Termos MeSH primário: Anemia Falciforme/fisiopatologia
Estresse Oxidativo/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Produtos da Oxidação Avançada de Proteínas/sangue
Antioxidantes/metabolismo
Viscosidade Sanguínea/fisiologia
Estudos de Casos e Controles
Criança
Endotelina-1/sangue
Feminino
Dedos/irrigação sanguínea
Doença da Hemoglobina SC/fisiopatologia
Hemólise/fisiologia
Seres Humanos
Fluxometria por Laser-Doppler/métodos
Masculino
Malondialdeído/sangue
Microcirculação/fisiologia
Óxido Nítrico/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Advanced Oxidation Protein Products); 0 (Antioxidants); 0 (Endothelin-1); 31C4KY9ESH (Nitric Oxide); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14693


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[PMID]:28468962
[Au] Autor:Gohar EY; Kasztan M; Becker BK; Speed JS; Pollock DM
[Ad] Endereço:Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
[Ti] Título:Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.
[So] Source:Am J Physiol Renal Physiol;313(2):F361-F369, 2017 Aug 01.
[Is] ISSN:1522-1466
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We recently reported that natriuresis produced by renal medullary salt loading is dependent on endothelin (ET)-1 and purinergic (P2) receptors in male rats. Because sex differences in ET-1 and P2 signaling have been reported, we decided to test whether ovarian sex hormones regulate renal medullary ET-1 and P2-dependent natriuresis. The effect of medullary NaCl loading on Na excretion was determined in intact and ovariectomized (OVX) female Sprague-Dawley rats with and without ET-1 or P2 receptor antagonism. Isosmotic saline (284 mosmol/kgH O) was infused in the renal medullary interstitium of anesthetized rats during a baseline urine collection period, followed by isosmotic or hyperosmotic saline (1,800 mosmol/kgH O) infusion. Medullary NaCl loading significantly enhanced Na excretion in intact and OVX female rats. ET or P2 receptor blockade did not attenuate the natriuretic effect of medullary NaCl loading in intact females, whereas ET or P2 receptor blockade attenuated the natriuretic response to NaCl loading in OVX rats. Activation of medullary P2Y and P2Y receptors by UTP infusion had no significant effect in intact females but enhanced Na excretion in OVX rats. Combined ET receptor blockade significantly inhibited the natriuretic response to UTP observed in OVX rats. These data demonstrate that medullary NaCl loading induces ET-1 and P2-independent natriuresis in intact females. In OVX, activation of medullary P2 receptors promotes ET-dependent natriuresis, suggesting that ovarian hormones may regulate the interplay between the renal ET-1 and P2 signaling systems to facilitate Na excretion.
[Mh] Termos MeSH primário: Endotelina-1/metabolismo
Medula Renal/metabolismo
Natriurese
Ovariectomia
Receptores Purinérgicos P2Y2/metabolismo
Receptores Purinérgicos P2/metabolismo
Eliminação Renal
Sódio/urina
[Mh] Termos MeSH secundário: Animais
Antagonistas dos Receptores de Endotelina/farmacologia
Endotelina-1/genética
Feminino
Medula Renal/efeitos dos fármacos
Natriurese/efeitos dos fármacos
Agonistas do Receptor Purinérgico P2/farmacologia
Antagonistas do Receptor Purinérgico P2/farmacologia
Ratos Sprague-Dawley
Receptores Purinérgicos P2/efeitos dos fármacos
Receptores Purinérgicos P2Y2/efeitos dos fármacos
Eliminação Renal/efeitos dos fármacos
Transdução de Sinais
Cloreto de Sódio/administração & dosagem
Cloreto de Sódio/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endothelin Receptor Antagonists); 0 (Endothelin-1); 0 (P2ry2 protein, rat); 0 (Purinergic P2 Receptor Agonists); 0 (Purinergic P2 Receptor Antagonists); 0 (Receptors, Purinergic P2); 0 (Receptors, Purinergic P2Y2); 0 (purinoceptor P2Y4); 451W47IQ8X (Sodium Chloride); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1152/ajprenal.00098.2017


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[PMID]:27777505
[Au] Autor:Kosior-Jarecka E; Wróbel-Dudzinska D; Lukasik U; Aung T; Khor CC; Kocki J; Zarnowski T
[Ad] Endereço:Department of Diagnostics and Microsurgery of Glaucoma, Medical University, Lublin, Poland.
[Ti] Título:Plasma endothelin-1 and single nucleotide polymorphisms of as risk factors for normal tension glaucoma.
[So] Source:Mol Vis;22:1256-1266, 2016.
[Is] ISSN:1090-0535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to determine whether four single nucleotide polymorphisms (SNPs) of can constitute a risk factor for normal tension glaucoma (NTG) and high tension glaucoma (HTG). METHODS: The study included 160 patients with NTG, 124 patients with HTG, and 165 healthy controls. To analyze the frequency of polymorphic variants of the (K198N) and the (C1222T, C70G, G231A), DNA was isolated from peripheral blood, and SNP genotyping was performed using the real-time PCR (RT-PCR) method. Plasma endothelin (ET) concentrations were detected using an enzyme immunoassay. Endothelin levels were compared with genotype and allele distributions, patients' clinical status, and various risk factors for NTG. RESULTS: There was a significant difference between the patients with NTG and HTG and the controls (p = 0.035, p = 0.008) regarding the genotype of the C1222T and C70G polymorphism. Plasma concentrations of ET did not differ between the NTG and HTG groups, and no significant correlation with intraocular pressure (IOP), best-corrected visual acuity (BCVA), and the cup to disc ratio (c/d ratio) was seen in patients with NTG. Plasma endothelin levels showed a noticeably positive correlation with age in the NTG group (R = 0.249, p = 0.042). Higher endothelin levels corresponded to more advanced visual field damage. No statistical difference was observed between variant genotypes of K198N and the ET-1 plasma concentration in patients with NTG, whereas a slightly higher ET level was observed in the patients with HTG with the GT genotype in comparison to those with the GG genotype (p = 0.001). The C1222T polymorphism significantly affected the plasma ET level in patients with NTG. The TT genotype carriers had the highest ET level, and the CC genotype carriers the lowest (p = 0.034). The AA variant genotype of the G231A polymorphism exhibited the highest ET level, while the GG variant genotype represented the lowest level (p = 0.033). No significant differences were observed regarding the endothelin levels and the frequency of notches, peripapillary atrophy, low blood pressure, cold extremities, or migraine in the two groups studied. Slightly lower endothelin plasma levels were observed in patients with optic disc hemorrhages in the NTG group (p = 0.05). CONCLUSIONS: Polymorphic variants of (K198N) and (C1222T, C70G, G231A) affected ET plasma concentrations. There was no association between the plasma endothelin levels and the risk factors for NTG. According to these results, plasma endothelin concentrations do not appear to be a marker for NTG.
[Mh] Termos MeSH primário: Endotelina-1/sangue
Endotelina-1/genética
Glaucoma de Baixa Tensão/genética
Polimorfismo de Nucleotídeo Único
Receptor de Endotelina A/genética
[Mh] Termos MeSH secundário: Idoso
Ensaio de Imunoadsorção Enzimática
Feminino
Técnicas de Genotipagem
Seres Humanos
Pressão Intraocular
Glaucoma de Baixa Tensão/sangue
Masculino
Reação em Cadeia da Polimerase em Tempo Real
Fatores de Risco
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endothelin-1); 0 (Receptor, Endothelin A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29203627
[Au] Autor:Schinzari F; Tesauro M; Veneziani A; Mores N; Di Daniele N; Cardillo C
[Ad] Endereço:From the Policlinico A. Gemelli, Rome, Italy (F.S., A.V., N.M., C.C.); Department of Internal Medicine, University of Tor Vergata, Rome, Italy (M.T., N.D.D.); and Departments of Surgery (A.V.), Pharmacology (N.M.), and Internal Medicine (C.C.), Catholic University, Rome, Italy.
[Ti] Título:Favorable Vascular Actions of Angiotensin-(1-7) in Human Obesity.
[So] Source:Hypertension;71(1):185-191, 2018 01.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obese patients have vascular dysfunction related to impaired insulin-stimulated vasodilation and increased endothelin-1-mediated vasoconstriction. In contrast to the harmful vascular actions of angiotensin (Ang) II, the angiotensin-converting enzyme 2 product Ang-(1-7) has shown to exert cardiovascular and metabolic benefits in experimental models through stimulation of the Mas receptor. We, therefore, examined the effects of exogenous Ang-(1-7) on vasodilator tone and endothelin-1-dependent vasoconstriction in obese patients. Intra-arterial infusion of Ang-(1-7) (10 nmol/min) resulted in significant increase in unstimulated forearm flow ( =0.03), an effect that was not affected by the Mas receptor antagonist A779 (10 nmol/min; >0.05). In the absence of hyperinsulinemia, however, forearm flow responses to graded doses of acetylcholine and sodium nitroprusside were not different during Ang-(1-7) administration compared with saline (both >0.05). During infusion of regular insulin (0.15 mU/kg per minute), by contrast, endothelium-dependent vasodilator response to acetylcholine was significantly enhanced by Ang-(1-7) ( =0.04 versus saline), whereas endothelium-independent response to sodium nitroprusside was not modified ( =0.91). Finally, Ang-(1-7) decreased the vasodilator response to endothelin A receptor blockade (BQ-123; 10 nmol/min) compared with saline (6±1% versus 93±17%; <0.001); nitric oxide inhibition by l- -monomethylarginine (4 µmol/min) during concurrent endothelin A antagonism resulted in similar vasoconstriction in the absence or presence of Ang-(1-7 Ang-(1-7) ( =0.69). Our findings indicate that in obese patients Ang-(1-7) has favorable effects not only to improve insulin-stimulated endothelium-dependent vasodilation but also to blunt endothelin-1-dependent vasoconstrictor tone. These findings provide support for targeting Ang-(1-7) to counteract the hemodynamic abnormalities of human obesity.
[Mh] Termos MeSH primário: Angiotensina I/metabolismo
Endotelina-1/metabolismo
Insulina
Obesidade
Fragmentos de Peptídeos/metabolismo
Fluxo Sanguíneo Regional/efeitos dos fármacos
Vasoconstrição
Vasodilatação
[Mh] Termos MeSH secundário: Adulto
Feminino
Antebraço/irrigação sanguínea
Seres Humanos
Insulina/metabolismo
Insulina/farmacocinética
Masculino
Meia-Idade
Obesidade/metabolismo
Obesidade/fisiopatologia
Receptor de Endotelina A/metabolismo
Fluxo Sanguíneo Regional/fisiologia
Estatística como Assunto
Vasoconstrição/efeitos dos fármacos
Vasoconstrição/fisiologia
Vasoconstritores/farmacologia
Vasodilatação/efeitos dos fármacos
Vasodilatação/fisiologia
Vasodilatadores/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Endothelin-1); 0 (Insulin); 0 (Peptide Fragments); 0 (Receptor, Endothelin A); 0 (Vasoconstrictor Agents); 0 (Vasodilator Agents); 9041-90-1 (Angiotensin I); IJ3FUK8MOF (angiotensin I (1-7))
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180113
[Lr] Data última revisão:
180113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.10280


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[PMID]:27770564
[Au] Autor:Liu D; Zhou JL; Hong F; Zhang YQ
[Ad] Endereço:Department of Applied Biology, School of Basic Medical and Biological Sciences, Soochow University, RM702-2303, Renai Road No. 199, Dushuhu Higher Edu. Town, Suzhou, 215123, People's Republic of China.
[Ti] Título:Lung inflammation caused by long-term exposure to titanium dioxide in mice involving in NF-κB signaling pathway.
[So] Source:J Biomed Mater Res A;105(3):720-727, 2017 03.
[Is] ISSN:1552-4965
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Titanium dioxide nanoparticles (TiO NPs) are used in many fields, such as paints, medicine additives, food additives, sunscreens, and agriculture. The aim of this study was to investigate the mechanism behind the formation of inflammation induced by TiO NPs. ICR mice were exposed to TiO NPs through intragastric administration at 2.5, 5, and 10 mg/kg body weight every day for 90 consecutive days. The experiment suggested that long-term exposure to TiO NPs resulted in an obvious inflammatory response in mice lung tissues, which led to a thickened alveoli septum, lung hyperemia, and titanium accumulation. Furthermore, our results show that TiO NPs exposure remarkably altered the expression of inflammation-related cytokines, with increases in proinflammatory cytokines-such as nucleic factor-κB, interferon-α, interferon-ß, interleukin-1ß, interleukin-6, cyclo-oxygen-ase, interleukin-8, interferon-inducible protein-10, and platelet-derived growth factor AB-and decreases in anti-inflammatory cytokines-such as inhibitor of NF-κB suppressor of cytokine signaling 1, endothelin 1, peroxisome proliferators-activated receptors-γ, and peroxisome proliferators-activated receptors coactivator-1α. This finding indicated that TiO NPs cause lung inflammation in mice after intragastric administration, primarily through the NF-κB signaling pathways. Therefore, more attention should be placed on the application of TiO NPs and their potential long-term effects, especially in human beings. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 720-727, 2017.
[Mh] Termos MeSH primário: NF-kappa B/toxicidade
Pneumonia
Transdução de Sinais/efeitos dos fármacos
Titânio/toxicidade
[Mh] Termos MeSH secundário: Animais
Citocinas/metabolismo
Endotelina-1/metabolismo
Feminino
Camundongos
Camundongos Endogâmicos ICR
PPAR gama/metabolismo
Pneumonia/induzido quimicamente
Pneumonia/metabolismo
Pneumonia/patologia
Proteína 1 Supressora da Sinalização de Citocina/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Endothelin-1); 0 (NF-kappa B); 0 (PPAR gamma); 0 (Socs1 protein, mouse); 0 (Suppressor of Cytokine Signaling 1 Protein); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1002/jbm.a.35945



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