Base de dados : MEDLINE
Pesquisa : D12.644.456.345.190 [Categoria DeCS]
Referências encontradas : 889 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 89 ir para página                         

  1 / 889 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28690302
[Au] Autor:Tahara S; Yamamoto S; Yamajima Y; Miyakawa H; Uematsu Y; Monma K
[Ad] Endereço:Tokyo Metropolitan Institute of Public Health.
[Ti] Título:A Rapid Dialysis Method for Analysis of Artificial Sweeteners in Foods (2nd Report).
[So] Source:Shokuhin Eiseigaku Zasshi;58(3):124-131, 2017.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Following the previous report, a rapid dialysis method was developed for the extraction and purification of four artificial sweeteners, namely, sodium saccharide (Sa), acesulfame potassium (AK), aspartame (APM), and dulcin (Du), which are present in various foods. The method was evaluated by the addition of 0.02 g/kg of these sweeteners to a cookie sample, in the same manner as in the previous report. Revisions from the previous method were: reduction of the total dialysis volume from 200 to 100 mL, change of tube length from 55 to 50 cm, change of dialysate from 0.01 mol/L hydrochloric aqueous solution containing 10% sodium chloride to 30% methanol solution, and change of dialysis conditions from ambient temperature with occasional shaking to 50℃ with shaking at 160 rpm. As a result of these revisions, the recovery reached 99.3-103.8% with one hour dialysis. The obtained recovery yields were comparable to the recovery yields in the previous method with four hour dialysis.
[Mh] Termos MeSH primário: Aspartame/análise
Aspartame/isolamento & purificação
Diálise/métodos
Análise de Alimentos/métodos
Compostos de Fenilureia/análise
Compostos de Fenilureia/isolamento & purificação
Sacarina/análise
Sacarina/isolamento & purificação
Edulcorantes/análise
Edulcorantes/isolamento & purificação
Tiazinas/análise
Tiazinas/isolamento & purificação
[Mh] Termos MeSH secundário: Carbonato de Cálcio
Cromatografia Líquida de Alta Pressão
Citratos
Soluções para Diálise
Combinação de Medicamentos
Temperatura Alta
Ácido Clorídrico
Óxido de Magnésio
Metanol
Cloreto de Sódio
Fatores de Tempo
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Citrates); 0 (Dialysis Solutions); 0 (Drug Combinations); 0 (Phenylurea Compounds); 0 (Suby's G solution); 0 (Sweetening Agents); 0 (Thiazines); 059QF0KO0R (Water); 3A3U0GI71G (Magnesium Oxide); 451W47IQ8X (Sodium Chloride); 8U78KF577Z (dulcin); FST467XS7D (Saccharin); H0G9379FGK (Calcium Carbonate); MA3UYZ6K1H (acetosulfame); QTT17582CB (Hydrochloric Acid); Y4S76JWI15 (Methanol); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.58.124


  2 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28686282
[Au] Autor:Aya-Ramos L; Contreras-Vargas C; Rico JL; Dueñas Z
[Ad] Endereço:Universidad Nacional de Colombia, Bogotá, Facultad de Medicina, Departamento de Ciencias fisiológicas, Grupo neurobiología y comportamiento, Bogotá, D.C. 11001, Colombia. zjduenasg@unal.edu.co.
[Ti] Título:Early maternal separation induces preference for sucrose and aspartame associated with increased blood glucose and hyperactivity.
[So] Source:Food Funct;8(7):2592-2600, 2017 Jul 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Early life stress and exposure to sweeteners lead to physiological and behavioral alterations in adulthood. Nevertheless, many genetic and environmental factors as well as the neurobiological mechanisms that contribute to the development of these disorders are not fully understood. Similarly, evidence about the long-term metabolic effects of exposure to sweeteners in early life is limited and inconsistent. This study used an animal model of maternal separation during breastfeeding (MS) to analyze the effects of early life stress on consumption of sweeteners, weight gain, blood glucose and locomotion. Rats were housed under a reversed light/dark cycle (lights off at 7:00 h) with ad libitum access to water and food. In the MS protocol, MS pups were separated from the dam for 6 h per day in two periods of 180 minutes (7:00-10:00 and 13:00-16:00 h) during the dark phase of postnatal day (PND) 1 to PND 21. Non-separated (NS) pups served as controls. On PND 22 rats were grouped by sex and treatment. From PND 26 to PND 50 sucrose and aspartame were provided to rats, and sweetener intake, body weight and blood glucose-related measures were scored. On PND 50, both male and female rats were exposed to the open field test to obtain locomotion and anxiety-related measures. Results showed that both early maternal separation and sweetener intake during adolescence resulted in increased blood glucose and hyperactivity in male rats but not in female rats. Data suggest that the combination of early stress and exposure to sucrose and aspartame could be a risk factor for the development of chronic diseases such as diabetes, as well as for behavioral alterations.
[Mh] Termos MeSH primário: Ansiedade/psicologia
Aspartame/metabolismo
Glicemia/metabolismo
Preferências Alimentares
Privação Materna
Sacarose/metabolismo
[Mh] Termos MeSH secundário: Animais
Ansiedade/metabolismo
Ansiedade/fisiopatologia
Peso Corporal
Modelos Animais de Doenças
Feminino
Seres Humanos
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 57-50-1 (Sucrose); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00408g


  3 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28415925
[Au] Autor:Parker W; Hornik CD; Bilbo S; Holzknecht ZE; Gentry L; Rao R; Lin SS; Herbert MR; Nevison CD
[Ad] Endereço:1 Departments of Surgery, Duke University Medical Center, Durham, NC USA.
[Ti] Título:The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism.
[So] Source:J Int Med Res;45(2):407-438, 2017 Apr.
[Is] ISSN:1473-2300
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The wide range of factors associated with the induction of autism is invariably linked with either inflammation or oxidative stress, and sometimes both. The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development. Thus, one explanation for the increased prevalence of autism is that increased exposure to acetaminophen, exacerbated by inflammation and oxidative stress, is neurotoxic in babies and small children. This view mandates extreme urgency in probing the long-term effects of acetaminophen use in babies and the possibility that many cases of infantile autism may actually be induced by acetaminophen exposure shortly after birth.
[Mh] Termos MeSH primário: Acetaminofen/efeitos adversos
Analgésicos não Entorpecentes/efeitos adversos
Transtorno Autístico/etiologia
Transtorno Autístico/fisiopatologia
Estresse Oxidativo
[Mh] Termos MeSH secundário: Aspartame/administração & dosagem
Aspartame/metabolismo
Aspartame/toxicidade
Transtorno Autístico/diagnóstico
Criança
Pré-Escolar
Feminino
Ácido Fólico/efeitos adversos
Seres Humanos
Hiperbilirrubinemia/complicações
Hiperbilirrubinemia/fisiopatologia
Lactente
Inflamação
Masculino
Metais Pesados/toxicidade
Organofosfatos/toxicidade
Gravidez
Fatores de Risco
Timerosal/toxicidade
Vitamina B 12/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Metals, Heavy); 0 (Organophosphates); 2225PI3MOV (Thimerosal); 362O9ITL9D (Acetaminophen); 935E97BOY8 (Folic Acid); P6YC3EG204 (Vitamin B 12); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1177/0300060517693423


  4 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28334211
[Au] Autor:Zhang X; Chen S; Li Z; Xu Y
[Ad] Endereço:Red Imported Fire Ant Research Center, South China Agricultural University, Guangzhou 510642, China (719855828@qq.com; xuyijuan@scau.edu.cn).
[Ti] Título:Effect of Sweeteners on the Survival of Solenopsis invicta (Hymenoptera: Formicidae).
[So] Source:J Econ Entomol;110(2):593-597, 2017 Apr 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The red imported fire ant, Solenopsis invicta Buren, is a serious agricultural, ecological, and public health pest in its invaded range. Chemical insecticides have been widely used for the prevention and control of this notorious pest. To search for novel, cost-effective, and environmentally friendly materials for fire ant control, we tested various sweeteners for their toxicity to S. invicta. The S. invicta that were fed erythritol, aspartame, and saccharin exhibited significantly higher mortality rates than those fed other sweeteners. After 72 h, the mortality of the workers that were fed 0.1 or 0.2 g/ml erythritol was above 80%. For males, females, and larvae, mortality was close to 100% after 9 d at high concentrations. Dose-dependent effects of erythritol were observed for workers, males, females, and larvae at the concentrations tested. Rapid transfer of toxicity among the fire ant colony was also observed. Our results suggest that erythritol can be developed as an additive ingredient in baits.
[Mh] Termos MeSH primário: Formigas/efeitos dos fármacos
Inseticidas/farmacologia
Edulcorantes/farmacologia
[Mh] Termos MeSH secundário: Animais
Formigas/fisiologia
Aspartame/farmacologia
Relação Dose-Resposta a Droga
Eritritol/farmacologia
Feminino
Controle de Insetos/métodos
Larva/efeitos dos fármacos
Masculino
Sacarina/farmacologia
Taxa de Sobrevida
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Sweetening Agents); FST467XS7D (Saccharin); RA96B954X6 (Erythritol); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox038


  5 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28298151
[Au] Autor:Taheri S
[Ad] Endereço:Children's Hospital of Western Ontario, Department of Academic Paediatrics, London, Canada.
[Ti] Título:Effect of exclusion of frequently consumed dietary triggers in a cohort of children with chronic primary headache.
[So] Source:Nutr Health;23(1):47-50, 2017 Mar.
[Is] ISSN:0260-1060
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although dietary factors are known to trigger headaches, the relationship between food and headache in children remains unclear. This prospective, observational case series aimed to evaluate the effect of exclusion of frequently-consumed foods in a cohort of children with headache. METHODS: One hundred and fifteen children aged 3-15 (mean 10.5) years with primary headache were followed in a paediatric outpatient clinic. Patients who frequently consumed foods or food additives known to trigger headaches were advised to exclude them for six weeks and to return for follow-up with headache and food diary. RESULTS: One hundred patients attended follow-up. Of these 13 (13%) did not respond to dietary exclusion; 87 (87%) achieved complete resolution of headaches by exclusion of 1-3 of the identified food(s). Caffeine was the most common implicated trigger (28), followed by monosodium glutamate (25), cocoa (22), aspartame (13), cheese (13), citrus (10) and nitrites (six). One patient was sensitive to tomatoes. CONCLUSIONS: This study demonstrates the potential scale and significance of seven frequently consumed foods or food additives as triggers for primary headache in children. Also this is the first study to show that headaches can be triggered by the cumulative effect of a food that is frequently consumed, rather than by single time ingestion.
[Mh] Termos MeSH primário: Dieta/efeitos adversos
Comportamento Alimentar
Cefaleia/dietoterapia
Transtornos de Enxaqueca/dietoterapia
[Mh] Termos MeSH secundário: Adolescente
Aspartame/administração & dosagem
Aspartame/efeitos adversos
Cacau/efeitos adversos
Cafeína/administração & dosagem
Cafeína/efeitos adversos
Queijo/efeitos adversos
Criança
Pré-Escolar
Chocolate/efeitos adversos
Citrus/efeitos adversos
Registros de Dieta
Feminino
Aditivos Alimentares/administração & dosagem
Aditivos Alimentares/efeitos adversos
Cefaleia/etiologia
Transtornos da Cefaleia/dietoterapia
Transtornos da Cefaleia/etiologia
Seres Humanos
Masculino
Transtornos de Enxaqueca/etiologia
Nitritos/administração & dosagem
Nitritos/efeitos adversos
Fatores Desencadeantes
Estudos Prospectivos
Glutamato de Sódio/administração & dosagem
Glutamato de Sódio/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives); 0 (Nitrites); 3G6A5W338E (Caffeine); W81N5U6R6U (Sodium Glutamate); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1177/0260106016688699


  6 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28277180
[Au] Autor:Lee Y; Do B; Lee G; Lim HS; Yun SS; Kwon H
[Ad] Endereço:a Department of Food and Nutrition , Seoul National University , Seoul , Korea.
[Ti] Título:Simultaneous determination of sodium saccharin, aspartame, acesulfame-K and sucralose in food consumed in Korea using high-performance liquid chromatography and evaporative light-scattering detection.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;34(5):666-677, 2017 May.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four artificial sweeteners, i.e., sodium saccharin, aspartame, acesulfame-K and sucralose, are permitted for use in Korea, and recent regulatory changes have expanded the number of food categories in which they may be used. Four artificial sweeteners were determined simultaneously in more than 900 food items from 30 food categories that are commercially available in Korean markets, including both domestic and imported products, using high-performance liquid chromatography and evaporative light-scattering detection (ELSD). A new procedure using 75% acetone to remove fat was applied for sample preparation. The levels detected in all samples were below the maximum permitted use levels established in Korea. Despite the increased number of categories, the only one in which sodium saccharin was newly found was takju, an alcoholic beverage. Sodium saccharin was not found in other beverages in the food analysis or in the food label survey, even though its use was reported in a previous study, suggesting that consumer preference outweighs regulatory decisions. When the analytical results were combined with food-consumption data obtained from the Korea National Health and Nutrition Examination Survey 2010-14, the estimated daily intakes of all the sweeteners were considered safe.
[Mh] Termos MeSH primário: Aspartame/análise
Difusão Dinâmica da Luz
Análise de Alimentos
Sacarina/análise
Sacarina/química
Sacarose/análogos & derivados
Tiazinas/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Seres Humanos
República da Coreia
Sacarose/análise
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Thiazines); 57-50-1 (Sucrose); 96K6UQ3ZD4 (trichlorosucrose); FST467XS7D (Saccharin); MA3UYZ6K1H (acetosulfame); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2017.1284348


  7 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28216168
[Au] Autor:Le Donne C; Mistura L; Goscinny S; Janvier S; Cuypers K; D'Addezio L; Sette S; Catasta G; Ferrari M; Piccinelli R; Van Loco J; Turrini A
[Ad] Endereço:Council for Agricultural Research and Economics, Research Center on Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy. Electronic address: cinzia.ledonne@crea.gov.it.
[Ti] Título:Assessment of dietary intake of 10 intense sweeteners by the Italian population.
[So] Source:Food Chem Toxicol;102:186-197, 2017 Apr.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to monitor the consumption of foods containing intense sweeteners present on the Italian food market and to investigate whether the Italian general population (aged >3-65+) was at risk for exceeding the Acceptable Daily Intake (ADI) of 10 intense sweeteners. A food label survey was performed in Rome (Italy), using market share data to identify the brands more representative of the market. A sample of 326 foods (table-top sweeteners included), beverages and food supplements containing intense sweeteners was collected and analyzed in order to establish the concentration levels. Intense sweeteners were only found in foods belonging to 8 sugar-free food categories out of 37 regulated. The dietary exposure was estimated using the tiered approach. Food consumption data from the last Italian national survey (INRAN-SCAI 2005-06) were combined with Maximum Levels at Tier 2, and with the actual concentration of sweeteners in the collected food products at Tier 3. The estimated exposure among consumers of sweeteners in Italy was well below the ADIs, in both tiers; non-alcoholic beverages, table-top sweeteners and food supplements were main contributors to exposure.
[Mh] Termos MeSH primário: Bebidas
Suplementos Nutricionais
Rotulagem de Alimentos
Edulcorantes/administração & dosagem
Edulcorantes/análise
[Mh] Termos MeSH secundário: Aspartame/análise
Bebidas/análise
Bebidas/estatística & dados numéricos
Inquéritos sobre Dietas
Suplementos Nutricionais/análise
Suplementos Nutricionais/estatística & dados numéricos
Seres Humanos
Itália
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sweetening Agents); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


  8 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Registro de Ensaios Clínicos
[PMID]:28157063
[Au] Autor:Valeur KS; Hertel SA; Lundstrøm KE; Holst H
[Ad] Endereço:kristine.svinning.valeur.01@regionh.dk.
[Ti] Título:Safe excipient exposure in neonates and small children - protocol for the SEEN project.
[So] Source:Dan Med J;64(2), 2017 Feb.
[Is] ISSN:2245-1919
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners varied by route of administration (more common by enteral than parenteral route), and regional differences were revealed. The survey did not identify if the content of excipients was more pronounced in medications prescribed for specific medical diseases, e.g. more common in cardiovascular conditions than lung diseases. Furthermore, the quantitative amount of e.g. ethanol in the multi-medicated neonate has not been investigated. The aim of the present study was to quantify the total amount of excipients administered to poly-medicated neonatal and paediatric patients during hospitalisation; and to investigate if any particular medical diseases are treated with potentially harmful excipients. METHODS: This is a retrospective cohort study based on chart-audit on multi-medicated patients ≤ 5 years of age treated at the Rigshospitalet, Denmark. Preparations with ethanol, propylene glycol, benzyl alcohol, parabens, acesulfame p, aspartame, glycerol, sorbitol and polysorbate-80 will be recorded and cumulative amounts will be calculated. CONCLUSION: By quantifying the amount of harmful excipients to which paediatric patients are exposed, the study will contribute to a risk/benefit assessment of the medication standards of neonatal and paediatric patients. FUNDING: The Danish Council for Independent Research, grant-id: DFF - 6110-00266. TRIAL REGISTRATION: This study was registered at clinicaltrials.gov (reg. no. NCT02545712).
[Mh] Termos MeSH primário: Excipientes/administração & dosagem
Auditoria Médica
[Mh] Termos MeSH secundário: Aspartame/administração & dosagem
Álcool Benzílico/administração & dosagem
Criança
Pré-Escolar
Etanol/administração & dosagem
Glicerol/administração & dosagem
Seres Humanos
Lactente
Recém-Nascido
Propilenoglicol/administração & dosagem
Projetos de Pesquisa
Estudos Retrospectivos
Tiazinas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Thiazines); 3K9958V90M (Ethanol); 6DC9Q167V3 (Propylene Glycol); LKG8494WBH (Benzyl Alcohol); MA3UYZ6K1H (acetosulfame); PDC6A3C0OX (Glycerol); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


  9 / 889 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28150114
[Au] Autor:Mahnam K; Raisi F
[Ad] Endereço:Biology Department, Faculty of Sciences, Shehrekord University, Shahrekord, Iran. karimmahnam93@gmail.com.
[Ti] Título:A theoretical and experimental study of calcium, iron, zinc, cadmium, and sodium ions absorption by aspartame.
[So] Source:J Biol Phys;43(1):87-103, 2017 Mar.
[Is] ISSN:1573-0689
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Aspartame (L-Aspartyl-L-phenylalanine methyl ester) is a sweet dipeptide used in some foods and beverages. Experimental studies show that aspartame causes osteoporosis and some illnesses, which are similar to those of copper and calcium deficiency. This raises the issue that aspartame in food may interact with cations and excrete them from the body. This study aimed to study aspartame interaction with calcium, zinc, iron, sodium, and cadmium ions via molecular dynamics simulation (MD) and spectroscopy. Following a 480-ns molecular dynamics simulation, it became clear that the aspartame is able to sequester Fe , Ca , Cd , and Zn ions for a long time. Complexation led to increasing UV-Vis absorption spectra and emission spectra of the complexes. This study suggests a potential risk of cationic absorption of aspartame. This study suggests that purification of cadmium-polluted water by aspartame needs a more general risk assessment.
[Mh] Termos MeSH primário: Absorção Fisico-Química
Aspartame/química
Metais/química
Simulação de Dinâmica Molecular
[Mh] Termos MeSH secundário: Cádmio/química
Cálcio/química
Ferro/química
Conformação Molecular
Sódio/química
Espectrometria de Fluorescência
Espectrofotometria Ultravioleta
Análise Espectral
Eletricidade Estática
Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals); 00BH33GNGH (Cadmium); 9NEZ333N27 (Sodium); E1UOL152H7 (Iron); J41CSQ7QDS (Zinc); SY7Q814VUP (Calcium); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1007/s10867-016-9435-2


  10 / 889 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28071796
[Au] Autor:Wardy W; Chonpracha P; Chokumnoyporn N; Sriwattana S; Prinyawiwatkul W; Jirangrat W
[Ad] Endereço:School of Nutrition and Food Sciences, Louisiana State Univ. Agricultural Center, Baton Rouge, LA, 70803-4200, USA.
[Ti] Título:Influence of Package Visual Cues of Sweeteners on the Sensory-Emotional Profiles of Their Products.
[So] Source:J Food Sci;82(2):500-508, 2017 Feb.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Substantial evidence suggests influence of color, physical state, and other extrinsic features on consumer perception and acceptability of food products. In this study, 560 subjects evaluated liking and emotional responses associated with 5 sweeteners (sucralose, stevia, saccharin, aspartame, and sucrose) under 2 eliciting conditions: control (brand name only) and informed (brand name/packet image), to assess impact of the packet color. For a given condition, 5 identical tea samples each labeled with a sweetener type were rated for sweetness and overall liking (9-point) and emotions (5-point). Nonsignificant interactions between eliciting condition and sweetener type were found for liking attributes and emotions (except peaceful), indicating their independent effects. However, overall differences existed among sweetener types and eliciting conditions based on both hedonic and emotional responses (MANOVA, P < 0.05), suggesting modulating effects of packet color on sweetener type in the sensory-emotion space. The sensory-emotion profile for sucrose was separate from that of nonnutritive sweeteners, with statistically significant Mahalanobis distances among sample centroids. Increases in positive emotion intensities contrasted with a decrease in negative emotion intensities were observed for some sweeteners moving from the control to informed condition. Sweetness liking was strongly correlated with the emotion satisfied (sucralose, saccharin) only in the control condition, whereas it was strongly correlated with the emotions pleased and satisfied (stevia), disgusted (aspartame), and satisfied (sucrose) only in the informed condition. Overall, results suggested that sensory liking and emotions during the consumption experience are related not entirely to the type of sweetener, but also the color of the packet.
[Mh] Termos MeSH primário: Comportamento do Consumidor
Sinais (Psicologia)
Embalagem de Alimentos
Edulcorantes/química
Paladar
[Mh] Termos MeSH secundário: Adolescente
Adulto
Aspartame/química
Cor
Diterpenos Caurânicos/química
Emoções
Feminino
Rotulagem de Alimentos
Glucosídeos/química
Seres Humanos
Masculino
Adoçantes não Calóricos
Percepção
Satisfação Pessoal
Sacarina/química
Stevia/química
Sacarose/análogos & derivados
Sacarose/química
Chá
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Kaurane); 0 (Glucosides); 0 (Non-Nutritive Sweeteners); 0 (Sweetening Agents); 0 (Tea); 0YON5MXJ9P (stevioside); 57-50-1 (Sucrose); 96K6UQ3ZD4 (trichlorosucrose); FST467XS7D (Saccharin); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13610



página 1 de 89 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde