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  1 / 16497 MEDLINE  
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[PMID]:29236788
[Au] Autor:Smith JW; Kroker-Lobos MF; Lazo M; Rivera-Andrade A; Egner PA; Wedemeyer H; Torres O; Freedman ND; McGlynn KA; Guallar E; Groopman JD; Ramirez-Zea M
[Ad] Endereço:Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
[Ti] Título:Aflatoxin and viral hepatitis exposures in Guatemala: Molecular biomarkers reveal a unique profile of risk factors in a region of high liver cancer incidence.
[So] Source:PLoS One;12(12):e0189255, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Liver cancer is an emerging global health issue, with rising incidence in both the United States and the economically developing world. Although Guatemala experiences the highest rates of this disease in the Western hemisphere and a unique 1:1 distribution in men and women, few studies have focused on this population. Thus, we determined the prevalence and correlates of aflatoxin B1 (AFB1) exposure and hepatitis virus infection in Guatemalan adults. Healthy men and women aged ≥40 years (n = 461), residing in five departments of Guatemala, were enrolled in a cross-sectional study from May-October of 2016. Serum AFB1-albumin adducts were quantified using isotope dilution mass spectrometry. Multivariate linear regression was used to assess relationships between AFB1-albumin adduct levels and demographic factors. Biomarkers of hepatitis B virus and hepatitis C virus infection were assessed by immunoassay and analyzed by Fisher's exact test. AFB1-albumin adducts were detected in 100% of participants, with a median of 8.4 pg/mg albumin (range, 0.2-814.8). Exposure was significantly higher (p<0.05) in male, rural, low-income, and less-educated participants than in female, urban, and higher socioeconomic status participants. Hepatitis B and C seropositivity was low (0.9% and 0.5%, respectively). Substantial AFB1 exposure exists in Guatemalan adults, concurrent with low prevalence of hepatitis virus seropositivity. Quantitatively, AFB1 exposures are similar to those previously found to increase risk for liver cancer in Asia and Africa. Mitigation of AFB1 exposure may reduce liver cancer incidence and mortality in Guatemala, warranting further investigation.
[Mh] Termos MeSH primário: Aflatoxina B1/toxicidade
Exposição Ambiental
Hepatite B/epidemiologia
Hepatite C/epidemiologia
Neoplasias Hepáticas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Aflatoxina B1/sangue
Aflatoxinas/sangue
Idoso
Idoso de 80 Anos ou mais
Albuminas
Estudos Transversais
Feminino
Guatemala/epidemiologia
Hepatite B/complicações
Hepatite C/complicações
Seres Humanos
Incidência
Neoplasias Hepáticas/complicações
Masculino
Meia-Idade
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Albumins); 0 (aflatoxin-albumin adduct); 9N2N2Y55MH (Aflatoxin B1)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189255


  2 / 16497 MEDLINE  
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[PMID]:29384875
[Au] Autor:Jia Z; Liu H; Li W; Xie D; Cheng K; Pi X
[Ad] Endereço:Key Laboratory of Biorheology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing.
[Ti] Título:Electret filter collects more exhaled albumin than glass condenser: A method comparison based on human study.
[So] Source:Medicine (Baltimore);97(5):e9789, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years, noninvasive diagnosis based on biomarkers in exhaled breath has been extensively studied. The procedure of biomarker collection is a key step. However, the traditional condenser method has low efficacy in collecting nonvolatile compounds especially the protein biomarkers in breath. To solve this deficiency, here we propose an electret filter method.Exhaled breath of 6 volunteers was collected with a glass condenser and an electret filter. The amount of albumin was analyzed. Furthermore, the difference of exhaled albumin between smokers and nonsmokers was evaluated.The electret filter method collected more albumin than the glass condenser method at the same breath volume level (P < .01). Smokers exhaling more albumin than nonsmokers were also observed (P < .01).The electret filter is capable of collecting proteins more effectively than the condenser method. In addition, smokers tend to exhale more albumin than nonsmokers.
[Mh] Termos MeSH primário: Albuminas/análise
Testes Respiratórios/instrumentação
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/análise
Testes Respiratórios/métodos
Seres Humanos
Masculino
Meia-Idade
Fumar/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Albumins); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009789


  3 / 16497 MEDLINE  
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[PMID]:28450240
[Au] Autor:O'Shannessy DJ; Bendas K; Schweizer C; Wang W; Albone E; Somers EB; Weil S; Meredith RK; Wustner J; Grasso L; Landers M; Nicolaides NC
[Ad] Endereço:Morphotek, Inc., 210 Welsh Pool Rd, Exton, PA, USA.
[Ti] Título:Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer.
[So] Source:Genomics;109(3-4):251-257, 2017 07.
[Is] ISSN:1089-8646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Farletuzumab (FAR) is a humanized monoclonal antibody (mAb) that binds to folate receptor alpha. A Ph3 trial in ovarian cancer patients treated with carboplatin/taxane plus FAR or placebo did not meet the primary statistical endpoint. Subgroup analysis demonstrated that subjects with high FAR exposure levels (Cmin>57.6µg/mL) showed statistically significant improvements in PFS and OS. The neonatal Fc receptor (fcgrt) plays a central role in albumin/IgG stasis and mAb pharmacokinetics (PK). Here we evaluated fcgrt sequence and association of its promoter variable number tandem repeats (VNTR) and coding single nucleotide variants (SNV) with albumin/IgG levels and FAR PK in the Ph3 patients. A statistical correlation existed between high FAR Cmin and AUC in patients with the highest quartile of albumin and lowest quartile of IgG1. Analysis of fcgrt identified 5 different VNTRs in the promoter region and 9 SNVs within the coding region, 4 which are novel.
[Mh] Termos MeSH primário: Albuminas/farmacocinética
Anticorpos Monoclonais Humanizados/farmacocinética
Antígenos de Histocompatibilidade Classe I/genética
Imunoglobulina G/metabolismo
Neoplasias Ovarianas/tratamento farmacológico
Receptores Fc/genética
[Mh] Termos MeSH secundário: Albuminas/análise
Anticorpos Monoclonais Humanizados/farmacologia
Anticorpos Monoclonais Humanizados/uso terapêutico
Ensaios Clínicos Fase III como Assunto
Feminino
Seres Humanos
Imunoglobulina G/sangue
Repetições Minissatélites
Recidiva Local de Neoplasia
Neoplasias Ovarianas/metabolismo
Neoplasias Ovarianas/patologia
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Antibodies, Monoclonal, Humanized); 0 (Fc receptor, neonatal); 0 (Histocompatibility Antigens Class I); 0 (Immunoglobulin G); 0 (Receptors, Fc); 2O09BG0OWA (farletuzumab)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180218
[Lr] Data última revisão:
180218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  4 / 16497 MEDLINE  
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[PMID]:29221445
[Au] Autor:Kawamoto Y; Komatsu Y; Yuki S; Sawada K; Muranaka T; Harada K; Nakatsumi H; Fukushima H; Ishiguro A; Dazai M; Hatanaka K; Nakamura M; Iwanaga I; Uebayashi M; Sogabe S; Kobayashi Y; Miyagishima T; Ono K; Sakamoto N; Sakata Y
[Ad] Endereço:Department of Cancer Center, Hokkaido University Hospital, Sapporo, Japan.
[Ti] Título:Study protocol of HGCSG1404 SNOW study: a phase I/II trial of combined chemotherapy of S-1, nab-paclitaxel and oxaliplatin administered biweekly to patients with advanced gastric cancer.
[So] Source:BMC Cancer;17(1):837, 2017 12 08.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Japan, S-1 plus cisplatin (SP) regimen has become a standard therapy for patients with advanced gastric cancer. Moreover, the S-1 plus oxaliplatin regimen is now a standard treatment. Nab-paclitaxel was developed for chemotherapy of gastric cancer in Japanese clinical practice. Nab-paclitaxel, created with albumin-bound paclitaxel particles, has high transferability to tumour tissues and does not cause hypersensitivity reactions because of a different chemical composition compared with docetaxel and paclitaxel. A combination of S-1, nab-paclitaxel and oxaliplatin (which we named 'SNOW regimen') can be a promising triplet therapy for advanced gastric cancer. Although we have to pay attention to chemotherapy-induced neuropathy, we aim to investigate the recommended dose of this regimen in a phase I study. Furthermore, we will investigate its efficacy and toxicity in a phase II study. METHODS: The phase I study is a dose-escalation study using a standard 3 plus 3 design, followed by expansion cohorts. The SNOW regimen involves 28-day cycles with escalated doses of nab-paclitaxel (100-175 mg/m on days 1 and 15) and fixed doses of oxaliplatin (65 mg/ m on days 1 and 15) and S-1 (80 mg/m /day on day 1 to 14). The primary endpoints are assessment of dose limiting toxicities and determination of maximum tolerated dose to investigate the recommended dose in the subsequent phase II study. In the phase II study, the primary endpoint is objective response rate. Secondary endpoints are assessment of safety, progression-free survival, disease control rate, overall survival and time to treatment failure. Adverse events were monitored and graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. DISCUSSION: Triplet therapies for advanced gastric cancer patients have been evaluated in clinical trials. The SNOW regimen can be a promising new triplet therapy. TRIAL REGISTRATION: This study is performed at institutes that participate in Hokkaido Gastrointestinal Cancer Study Group (HGCSG) and registered as UMIN000016788 . Registrated 16 March 2015.
[Mh] Termos MeSH primário: Albuminas
Protocolos de Quimioterapia Combinada Antineoplásica
Compostos Organoplatínicos
Ácido Oxônico
Paclitaxel
Neoplasias Gástricas/tratamento farmacológico
Tegafur
[Mh] Termos MeSH secundário: Adulto
Albuminas/administração & dosagem
Albuminas/uso terapêutico
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Combinação de Medicamentos
Seres Humanos
Compostos Organoplatínicos/administração & dosagem
Compostos Organoplatínicos/uso terapêutico
Ácido Oxônico/administração & dosagem
Ácido Oxônico/uso terapêutico
Paclitaxel/administração & dosagem
Paclitaxel/uso terapêutico
Neoplasias Gástricas/mortalidade
Tegafur/administração & dosagem
Tegafur/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (130-nm albumin-bound paclitaxel); 0 (Albumins); 0 (Drug Combinations); 0 (Organoplatinum Compounds); 04ZR38536J (oxaliplatin); 150863-82-4 (S 1 (combination)); 1548R74NSZ (Tegafur); 5VT6420TIG (Oxonic Acid); P88XT4IS4D (Paclitaxel)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE
[do] DOI:10.1186/s12885-017-3850-z


  5 / 16497 MEDLINE  
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[PMID]:29300750
[Au] Autor:Guo HW; Yuan TZ; Chen JX; Zheng Y
[Ad] Endereço:Department of General Surgery, The Fourth Affiliated Hospital of Nan Chang University, Nanchang, Jiangxi, China.
[Ti] Título:Prognostic value of pretreatment albumin/globulin ratio in digestive system cancers: A meta-analysis.
[So] Source:PLoS One;13(1):e0189839, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The albumin/globulin ratio (AGR) has been widely reported to be a potential predictor of prognosis in digestive system cancers (DSCs), but convincing conclusions have not been made. Therefore, herein, we performed a meta-analysis of relevant studies regarding this topic to evaluate the prognostic value of AGR in patients with DSCs. Three databases, including PubMed, EMBase, and Web of science, were searched comprehensively for eligible studies through September 8, 2017. The outcomes of interest included overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). In our meta-analysis, pooled analysis of 13 studies with 9269 patients showed that a low AGR was significantly correlated with poor OS (HR = 1.94; 95% CI: 1.57-2.38; P <0.001). Five studies with 6538 participants involved DFS, and our pooled analysis of these studies also demonstrated that there was a significant association of a low AGR with worse DFS (HR = 1.49; 95% CI: 1.10 to 2.00; P < 0.001). In addition, only 2 studies referred to CSS, and we also detected a significant relationship between a low AGR and worse CSS from the results of our meta-analysis. In summary, a low pretreatment AGR was related to unfavorable survival in human digestive system cancers. A low pretreatment AGR may be a useful predictive prognostic biomarker in human digestive system cancers.
[Mh] Termos MeSH primário: Albuminas/metabolismo
Biomarcadores Tumorais/sangue
Neoplasias do Sistema Digestório/patologia
Globulinas/metabolismo
[Mh] Termos MeSH secundário: Neoplasias do Sistema Digestório/sangue
Seres Humanos
Prognóstico
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Albumins); 0 (Biomarkers, Tumor); 0 (Globulins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189839


  6 / 16497 MEDLINE  
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[PMID]:29374731
[Au] Autor:Saito N; Shirai Y; Horiuchi T; Sugano H; Shiba H; Sakamoto T; Uwagawa T; Yanaga K
[Ad] Endereço:Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan h24dr-saito@jikei.ac.jp.
[Ti] Título:Preoperative Platelet to Albumin Ratio Predicts Outcome of Patients with Cholangiocarcinoma.
[So] Source:Anticancer Res;38(2):987-992, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study was to evaluate the prognostic index of the preoperative platelet to albumin ratio (PAR) in patients who underwent primary resection for cholangiocarcinoma. PATIENTS AND METHODS: A total of 59 patients were divided into two groups: those with PAR ≥72.6×10 or <72.6×10 according to the area under the receiver operating characteristics curve. RESULTS: PAR was significantly inversely associated with overall (OS) and disease-free (DFS) survival on univariate analysis. PAR showed significance on multivariate analysis for OS (hazard ratio=6.232, 95% confidence interval=1.283-30.279, p=0.023), along with tumor differentiation (p=0.009), nodal involvement (p=0.001), intraoperative blood loss (p=0.001), and serum carcinoembryonic antigen (CEA) (p=0.012). High PAR was also significantly associated poor DFS on multivariate analysis (hazard ratio(HR)=4.422, 95% confidence interval(CI)=1.168-16.732, p=0.029), along with tumor differentiation (p=0.009). CONCLUSION: PAR is a useful prognostic index for OS and DFS in patients with cholangiocarcinoma after primary resection. By accumulating cases prospectively, this new index may be a reference for use before neoadjuvant chemotherapy.
[Mh] Termos MeSH primário: Albuminas/metabolismo
Neoplasias dos Ductos Biliares/patologia
Ductos Biliares Intra-Hepáticos/patologia
Plaquetas/patologia
Colangiocarcinoma/patologia
Hepatectomia/mortalidade
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias dos Ductos Biliares/metabolismo
Neoplasias dos Ductos Biliares/cirurgia
Ductos Biliares Intra-Hepáticos/metabolismo
Ductos Biliares Intra-Hepáticos/cirurgia
Biomarcadores Tumorais/análise
Colangiocarcinoma/metabolismo
Colangiocarcinoma/cirurgia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cuidados Pré-Operatórios
Prognóstico
Estudos Retrospectivos
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Biomarkers, Tumor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


  7 / 16497 MEDLINE  
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[PMID]:29173768
[Au] Autor:Yamauchi Y; Safi S; Muley T; Warth A; Herth FJF; Dienemann H; Hoffmann H; Eichhorn ME
[Ad] Endereço:Department of Thoracic Surgery, Thoraxklinik, Heidelberg University, Heidelberg, Germany; Translational Lung Research Center (TLRC), Heidelberg, Member of German Center for Lung Research (DZL), Germany.
[Ti] Título:C-reactive protein-albumin ratio is an independent prognostic predictor of tumor recurrence in stage IIIA-N2 lung adenocarcinoma patients.
[So] Source:Lung Cancer;114:62-67, 2017 Dec.
[Is] ISSN:1872-8332
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To systematically evaluate the prognostic value of nutrition/inflammation-based markers for recurrence-free survival (RFS) in pN2-stage IIIA lung adenocarcinoma patients. MATERIALS AND METHODS: Data from 156 patients who had pathologically confirmed pN2-stage IIIA primary lung adenocarcinoma and received complete surgical resection from 2010 to 2014 were retrospectively analyzed. The data for Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS, C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and prognostic nutritional index were analyzed. Univariate and multivariate Cox proportional-hazards regression analyses were used to identify the prognostic factors associated with RFS. RESULTS: The optimal cutoff value for the CAR was set at 0.6. A significant correlation was found between the CAR and RFS (P=0.001) by univariate analysis. Multivariate analysis between RFS and the factors selected from univariate analysis showed that ECOG performance status, pneumonectomy, multi-level N2, and high CAR were independent predictors of RFS. CONCLUSION: The CAR was the best prognostic marker to predict tumor recurrence in pN2-stage IIIA lung adenocarcinoma patients among the 7 nutrition/inflammation-based markers. The preoperative CAR may identify patients with a high risk of postoperative tumor recurrence.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Albuminas/análise
Proteína C-Reativa/análise
Inflamação/sangue
Neoplasias Pulmonares/patologia
Recidiva Local de Neoplasia/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/mortalidade
Adenocarcinoma/cirurgia
Adenocarcinoma/terapia
Idoso
Biomarcadores/sangue
Plaquetas/patologia
Quimiorradioterapia Adjuvante/métodos
Quimioterapia Adjuvante/métodos
Feminino
Seres Humanos
Inflamação/patologia
Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/cirurgia
Neoplasias Pulmonares/terapia
Linfócitos/patologia
Masculino
Meia-Idade
Recidiva Local de Neoplasia/sangue
Estadiamento de Neoplasias
Neutrófilos/patologia
Avaliação Nutricional
Valor Preditivo dos Testes
Prognóstico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Biomarkers); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  8 / 16497 MEDLINE  
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[PMID]:28465067
[Au] Autor:Mahdhaoui K; Fournier B; Derbanne MA
[Ad] Endereço:Unité de Recherche en Biomatériaux Innovants et Interfaces (URB2I)-EA4462, Faculté de Chirurgie Dentaire, Université Paris Descartes, Sorbonne Paris Cité, 1 rue Maurice Arnoux, 92120 Montrouge, France.
[Ti] Título:Unbound monomers do diffuse through the dentin barrier.
[So] Source:Dent Mater;33(6):743-751, 2017 06.
[Is] ISSN:1879-0097
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Assessing the role of dentinal fluid proteins in trans-dentinal diffusion of free monomers in vitro. METHODS: An artificial pulp chamber (APC) topped human dentin disks was used. A simplified two-step etch-and-rinse adhesive was formulated with 2-hydroethyl-methacrylate (HEMA), Bisphenol-A-diglycidyl-methacrylate (BisGMA), using Camphorquinone/tertiary amine as initiators. Two extraction media were used: buffered saline (Control), buffered saline with 1% bovine serum albumin (BSA). Samples were acid-etched, rinsed, air dried. Simplified primer was used, adhesive applied then light cured with a LED curing. Monomer diffusion was assessed by reverse phase HPLC. RESULTS: Quantifiable amounts of HEMA were detected in both extraction media while BisGMA was present in quantifiable amounts in BSA medium only. Diffused monomers concentrations were significantly higher for both monomers in BSA extraction medium. SIGNIFICANCE: Albumin is sometimes referred to as taxi protein for its ability to bind and transport hydrophobic ligands. From our results, we hypothesized that albumin can also transport unbound monomers released from dental adhesive through the dentin barrier. However, dentinal fluid proteins like albumin could have significant effect on monomer diffusion through dentin to the dental pulp transporting highly hydrophobic molecules like BisGMA and enhancing diffusion of more hydrophilic ones like HEMA. These results demonstrate a new possible mechanism for cytotoxicity of resin monomers.
[Mh] Termos MeSH primário: Albuminas/fisiologia
Bis-Fenol A-Glicidil Metacrilato
Cimentos Dentários
Adesivos Dentinários/farmacocinética
Dentina/metabolismo
Cimentos de Resina/farmacocinética
[Mh] Termos MeSH secundário: Ataque Ácido Dentário
Colagem Dentária
Seres Humanos
Metacrilatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Dental Cements); 0 (Dentin-Bonding Agents); 0 (Methacrylates); 0 (Resin Cements); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  9 / 16497 MEDLINE  
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[PMID]:29172757
[Au] Autor:Steins A; Ebbing EA; Pistorius MCM; Waasdorp C; Krishnadath KK; Medema JP; Wilmink JW; Mathôt RAA; Bijlsma MF; van Laarhoven HWM
[Ad] Endereço:a Cancer Center Amsterdam, Laboratory for Experimental Oncology and Radiobiology , Center for Experimental and Molecular Medicine, Academic Medical Center , Amsterdam , The Netherlands.
[Ti] Título:Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel.
[So] Source:Drug Deliv;24(1):1801-1810, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Angiogenesis is critical to the growth of tumors. Vascularization-targeting agents, with or without cytotoxic drugs, are widely used for the treatment of several solid tumors including esophagogastric adenocarcinoma. However, little is known about the systemic effects of anti-angiogenic therapies and how this affects the pharmacokinetics and intratumoral delivery of cytotoxic agents. In this study, patient-derived xenograft mouse models of esophageal adenocarcinoma were used to identify the effects of DC101, a murine vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, on the pharmacokinetics and the intratumoral uptake of nab-paclitaxel (NPTX). We showed that DC101 had large systemic effects resulting in decreased vasculature of intraperitoneally located organs. As a consequence, after intraperitoneal administration of NPTX, plasma uptake (5.029 ± 4.35 vs. 25.85 ± 2.27 µM) and intratumoral delivery (5.48 ± 5.32 vs. 38.49 ± 2.805 pmol/mg) of NPTX were greatly impaired in DC101-treated animals compared to control animals. Additionally, routes of NPTX elimination were altered upon angiogenesis inhibition; unchanged renal clearance and intraperitoneal accumulation of NPTX were observed, but NPTX levels were significantly lower in the liver. Histological examination of the intestine revealed a reduced thickness of the intestinal wall following DC101 therapy and suggested seepage of intraperitoneally injected NTPX through the intestinal wall to explain its reduced uptake in liver, plasma, and tumor tissue. These data explain several adverse effects observed in the clinic when using anti-angiogenic therapies and also imply that the combined use of anti-angiogenesis and cytotoxic agents in both preclinical and clinical setting is still suboptimal.
[Mh] Termos MeSH primário: Albuminas/farmacologia
Albuminas/farmacocinética
Inibidores da Angiogênese/farmacologia
Inibidores da Angiogênese/farmacocinética
Antineoplásicos/farmacologia
Neovascularização Patológica/tratamento farmacológico
Paclitaxel/farmacologia
Paclitaxel/farmacocinética
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/metabolismo
Antineoplásicos/farmacocinética
Feminino
Seres Humanos
Camundongos
Camundongos Nus
Neoplasias/tratamento farmacológico
Neoplasias/metabolismo
Neovascularização Patológica/metabolismo
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
Ensaios Antitumorais Modelo de Xenoenxerto/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (130-nm albumin-bound paclitaxel); 0 (Albumins); 0 (Angiogenesis Inhibitors); 0 (Antibodies, Monoclonal); 0 (Antineoplastic Agents); 0 (DC101 monoclonal antibody); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); P88XT4IS4D (Paclitaxel)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2017.1406559


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[PMID]:29244915
[Au] Autor:Ivanov YD; Malsagova KA; Tatur VY; Vesnin SG; Ivanova ND; Ziborov VS
[Ti] Título:SHF radiation from albumin solution upon external excitation.
[So] Source:Patol Fiziol Eksp Ter;60(3):101-4, 2016 Jul-Sep.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose of the research consisted in the measurement of nonequilibrium radiation in superhigh frequency (SHF) range from aqueous solution of albumin upon its mechanical stimulation. Methods: the monitoring of change in the ratio between brightness temperatures TSHF and TIR values after the mechanical stimulation of aqueous solution of albumin in the measuring cell at 35-39°Ð¡. The measurements of brightness temperatures were carried out with use of radiothermometer. SHF frequency range corresponded to 3.4-4.2 GHz, SHF frequency range corresponded to 8-13 mm. Results: It was found that mechanical stimulation of aqueous solution of albumin at the temperature ~39°Ð¡, the change in the ratio between TSHF and TIR occurs. This corresponds to emergence of nonequilibrium SHF radiation from the solution near the phase transition with ~39°Ð¡ temperature. Conclusion: The effect of emergence of nonequilibrium SHF radiation from protein solution near its temperature 39°Ð¡ was found. This temperature corresponds to the temperature of human organism upon a number of pathological states connected with inflammatory processes. The discovered effect can be used in the development of novel non-invasive methods of disease diagnostics.
[Mh] Termos MeSH primário: Albuminas/química
Ondas de Rádio
[Mh] Termos MeSH secundário: Temperatura Alta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE



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