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Pesquisa : D12.776.034.841.603 [Categoria DeCS]
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[PMID]:29184996
[Au] Autor:Liu J; Liang Y; Shen J; Bai Q
[Ad] Endereço:Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Modern Separation Science Key Laboratory of Shaanxi Province, College of Chemistry & Materials Science, Northwest University, Xi'an, Shaanxi, 710069, China. jwliu@nwu.edu.cn.
[Ti] Título:Polymeric ionic liquid-assembled graphene-immobilized silica composite for selective isolation of human serum albumin from human whole blood.
[So] Source:Anal Bioanal Chem;410(2):573-584, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Polymeric ionic liquids (PILs) with 1-vinyl-3-ethylimidazolium cations and two different anions of Br and PF were assembled onto the surface of graphene (G) nanosheets. The derived two composites, i.e., PIL(Br)-G and PIL(PF )-G, were further efficiently immobilized onto the surface of silica nanoparticles via self-assembly technique. The obtained two PIL-G/SiO nanocomposites exhibited diverse adsorption performances toward proteins through adjusting the anions of PILs. Electrostatic attractions between proteins and the nanocomposites dominated protein adsorption, while the presence of PF anions weakened electrostatic interactions and deteriorated the selective adsorption of target protein, i.e., bovine serum albumin (BSA) in this case. Specifically, PIL(Br)-G/SiO nanocomposite displayed high selectivity toward BSA and a high adsorption efficiency of ca. 98% was achieved for 100 mg L BSA in a Britton-Robinson (B-R) buffer at pH 5. HPLC analysis demonstrated the selectivity of PIL(Br)-G/SiO nanocomposite toward BSA in the presence of abundant hemoglobin and cytochrome c. The practical applicability was verified by performing selective isolation of human serum albumin (HSA) from human whole blood. Graphical abstract Selective isolation of human serum albumin from blood by polymeric ionic liquid assembled graphene immobilized silica nanocomposite with tunable anions.
[Mh] Termos MeSH primário: Grafite/química
Líquidos Iônicos/química
Polímeros/química
Albumina Sérica Humana/isolamento & purificação
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Adsorção
Ânions/química
Seres Humanos
Concentração de Íons de Hidrogênio
Nanocompostos/química
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anions); 0 (Ionic Liquids); 0 (Polymers); 7631-86-9 (Silicon Dioxide); 7782-42-5 (Graphite); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0758-z


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[PMID]:29352308
[Au] Autor:Qian Q; You Z; Ye L; Che J; Wang Y; Wang S; Zhong B
[Ad] Endereço:College of Animal Sciences, Zhejiang University, Hangzhou, P. R. China.
[Ti] Título:High-efficiency production of human serum albumin in the posterior silk glands of transgenic silkworms, Bombyx mori L.
[So] Source:PLoS One;13(1):e0191507, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human serum albumin (HSA) is an important biological preparation with a variety of biological functions in clinical applications. In this study, the mRNA of a fusion transposase derived from the pESNT-PBase plasmid and a pBHSA plasmid containing the HSA gene under the control of a fibroin light chain (FL) promoter were co-injected into fertilized eggs. Fifty-six transgenic silkworm pedigrees expressing theexogenous recombinant HSA (rHSA) in the posterior silk glands (PSGs) with stable inheritance were successfully obtained. The SDS-PAGE and Western blot results confirmed that the rHSA was secreted into the transgenic silkworm cocoon, and the rHSA could be easily extracted with phosphate-buffered saline (PBS). In our research, the isolated highest amount rHSA constituted up to 29.1% of the total soluble protein of the cocoon shell, indicating that the transgenic silkworm produced an average of 17.4 µg/mg of rHSA in the cocoon shell. The production of soluble rHSA in the PSGs by means of generating transgenic silkworms is a novel approach, whereby a large amount of virus-free and functional HSA can be produced through the simple rearing of silkworms.
[Mh] Termos MeSH primário: Bombyx/genética
Bombyx/metabolismo
Albumina Sérica Humana/biossíntese
Albumina Sérica Humana/genética
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Bombyx/crescimento & desenvolvimento
Fibroínas/genética
Expressão Gênica
Genes de Insetos
Seres Humanos
Plasmídeos/genética
Regiões Promotoras Genéticas
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Recombinant Proteins); 9007-76-5 (Fibroins); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191507


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[PMID]:27771990
[Au] Autor:Pawar SK; Punith R; Naik RS; Seetharamappa J
[Ad] Endereço:a Department of Chemistry , Karnatak University , Dharwad 580003 , India.
[Ti] Título:Spectroscopic and molecular modeling approaches to investigate the binding of proton pump inhibitors to human serum albumin.
[So] Source:J Biomol Struct Dyn;35(15):3205-3220, 2017 Nov.
[Is] ISSN:1538-0254
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The interaction between two proton pump inhibitors viz., omeprazole (OME) and esomeprazole (EPZ) with human serum albumin (HSA) was studied by fluorescence, absorption, circular dichroism (CD), Fourier transform infrared spectroscopy (FT-IR), voltammetry, and molecular modeling approaches. The Stern-Volmer quenching constants (K ) for OME-HSA and EPZ-HSA systems obtained at different temperatures revealed that both OME and EPZ quenched the intensity of HSA through dynamic mode of quenching mechanism. The binding constants of OME-HSA and EPZ-HSA increased with temperature, indicating the increased stability of these systems at higher temperatures. Thermodynamic parameters viz., ∆H , ∆S , and ∆G were determined for both systems. These values revealed that both systems were stabilized by hydrophobic forces. The competitive displacement and molecular docking studies suggested that OME/EPZ was bound to Sudlow's site I in subdomain IIA in HSA. The extent of energy transfer from HSA to OME/EPZ and the distance of separation in tryptophan (Trp214) Trp214-OME and Trp214-EPZ was determined based on the theory of fluorescence resonance energy transfer. UV absorption, 3D fluorescence, and CD studies indicated that the binding of OME/EPZ to HSA has induced micro environmental changes around the protein which resulted changes in its secondary structure.
[Mh] Termos MeSH primário: Inibidores da Bomba de Prótons/química
Albumina Sérica Humana/química
[Mh] Termos MeSH secundário: Sítios de Ligação
Dicroísmo Circular
Transferência Ressonante de Energia de Fluorescência
Seres Humanos
Ligações de Hidrogênio
Interações Hidrofóbicas e Hidrofílicas
Simulação de Acoplamento Molecular
Ligação Proteica
Estrutura Secundária de Proteína
Espectroscopia de Infravermelho com Transformada de Fourier
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1080/07391102.2016.1251337


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[PMID]:29219627
[Au] Autor:Ferrer R; Mateu X; Maseda E; Yébenes JC; Aldecoa C; De Haro C; Ruiz-Rodriguez JC; Garnacho-Montero J
[Ad] Endereço:a Intensive Care Department , Vall d'Hebron University Hospital; Shock, Organ Dysfunction and Resuscitation Research Group (SODIR), Vall d'Hebron Institut de Recerca , Barcelona , Spain.
[Ti] Título:Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients.
[So] Source:Expert Rev Clin Pharmacol;11(2):125-137, 2018 Feb.
[Is] ISSN:1751-2441
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Effective resuscitation with human albumin solutions is achieved with less fluid than with crystalloid solutions. However, the role of albumin in today's critical care unit is also linked to its multiple pharmacological effects. Areas covered: The potential clinical benefits of albumin in select populations of critically ill patients like sepsis seem related to immunomodulatory and anti-inflammatory effects, antibiotic transportation and endothelial stabilization. Albumin transports many drugs used in critically ill patients. Such binding to albumin is frequently lessened in critically ill patients with hypoalbuminemia. These changes could result in sub-optimal treatment. Albumin has immunomodulatory capacity by binding several bacterial products. Albumin also influences vascular integrity, contributing to the maintenance of the normal capillary permeability. Moreover, the albumin molecule encompasses several antioxidant properties, thereby significantly reducing re-oxygenation injury, which is especially important in sepsis. In fact, most studies of albumin administration are a combination of a degree of resuscitation with a degree of maintenance or supplementation of albumin. Expert commentary: The potential clinical benefits of the use of albumin in selected critically ill patients such as sepsis seem related to its immunomodulatory and anti-inflammatory effects, antioxidant properties, antibiotic transportation and endothelial stabilization. Additional studies are warranted to further elucidate the underlying physiologic and molecular rationale.
[Mh] Termos MeSH primário: Estado Terminal
Sepse/tratamento farmacológico
Albumina Sérica Humana/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Hipoalbuminemia/tratamento farmacológico
Unidades de Terapia Intensiva
Soluções Isotônicas/administração & dosagem
Soluções Isotônicas/farmacologia
Ressuscitação/métodos
Sepse/fisiopatologia
Albumina Sérica Humana/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Isotonic Solutions); 0 (crystalloid solutions); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1080/17512433.2018.1412827


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[PMID]:29173357
[Au] Autor:Ghosh K; Muddeshwar MG; Ghosh K
[Ad] Endereço:Department of Clinical Biochemistry, (KG, MGM), Indira Gandhi Government Medical College Hospital, Maharashtra, India.
[Ti] Título:Ischemia Modified Albumin Test to Detect Early Diabetic Complications.
[So] Source:Am J Med Sci;354(5):467-470, 2017 11.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The objective of this study was to assess the albumin cobalt binding (ACB) test in a cohort of type 2 diabetes patients. The ACB test is a simple, inexpensive, sensitive and robust test that could have important clinical application in detecting complications of type 2 diabetes mellitus. MATERIALS AND METHODS: We tested patients with type 2 diabetes without any clinically detectable complications or without any other comorbid conditions for serum ACB levels along with an equal number of age- and sex-matched healthy control subjects. ACB levels were compared after the patients with diabetes were investigated for various complications using standard statistical tests of significance. RESULTS: A total of 100 patients with type 2 diabetes were studied with age- and sex-matched healthy control subjects. Of the 100 patients, 78 had different complications on detailed laboratory testing. The patients with complications had significantly higher ACB test results when compared to the patients with diabetes without complications and to that of the control subjects (0.62 ± 0.04, 0.42 ± 0.07, 0.30 ± 0.05absorbance units (ABSU)/mL, respectively. P < 0.001). All values in diabetics were significantly higher than that of controls. CONCLUSIONS: The serum ACB test is a sensitive indicator of complications developed in type 2 diabetes mellitus. Patients may be followed up with ACB results to detect early complications in this disease.
[Mh] Termos MeSH primário: Complicações do Diabetes/diagnóstico
Diabetes Mellitus Tipo 2/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores/metabolismo
Cobalto/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Albumina Sérica Humana/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (ischemia-modified albumin); 3G0H8C9362 (Cobalt); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29348537
[Au] Autor:Kotagiri N; Cooper ML; Rettig M; Egbulefu C; Prior J; Cui G; Karmakar P; Zhou M; Yang X; Sudlow G; Marsala L; Chanswangphuwana C; Lu L; Habimana-Griffin L; Shokeen M; Xu X; Weilbaecher K; Tomasson M; Lanza G; DiPersio JF; Achilefu S
[Ad] Endereço:Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
[Ti] Título:Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer.
[So] Source:Nat Commun;9(1):275, 2018 01 18.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment of disseminated cancer by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and a contact-facilitated nanomicelle technology enabled highly selective delivery and co-localization of titanocene and radiolabelled fluorodeoxyglucose in disseminated multiple myeloma cells. Selective ablation of the cancer cells was achieved without significant off-target toxicity to the resident stem cells. Genomic, proteomic and multimodal imaging analyses revealed that the downregulation of CD49d, one of the dimeric protein targets of the nanomicelles, caused therapy resistance in small clusters of cancer cells. Similar treatment of a highly metastatic breast cancer model using human serum albumin-titanocene formulation significantly inhibited cancer growth. This strategy expands the use of phototherapy for treating previously inaccessible metastatic disease.
[Mh] Termos MeSH primário: Neoplasias Mamárias Experimentais/terapia
Mieloma Múltiplo/terapia
Compostos Organometálicos/administração & dosagem
Fotoquimioterapia
Compostos Radiofarmacêuticos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Resistência a Medicamentos Antineoplásicos
Feminino
Integrina alfa4beta1
Camundongos Endogâmicos C57BL
Camundongos SCID
Micelas
Terapia de Alvo Molecular
Nanopartículas
Ratos
Albumina Sérica Humana
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Integrin alpha4beta1); 0 (Micelles); 0 (Organometallic Compounds); 0 (Radiopharmaceuticals); 1271-29-0 (titanocene); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02758-9


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[PMID]:28465079
[Au] Autor:Naldi M; Baldassarre M; Domenicali M; Bartolini M; Caraceni P
[Ad] Endereço:Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126, Italy; Center for Applied Biomedical Research (C.R.B.A.), S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy.
[Ti] Título:Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis.
[So] Source:J Pharm Biomed Anal;144:138-153, 2017 Sep 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human serum albumin (HSA) is the most abundant circulating plasma protein. Besides a significant contribution to the osmotic pressure, it is also involved in the fine regulation of many other physiological processes, including the balance of the redox state, the inflammatory and/or immunological responses, and the pharmacokinetic and pharmacodynamics of many drugs. Growing evidence suggests that HSA undergoes structural and functional damage in diseases characterized by an enhanced systemic inflammatory response and oxidative stress, as it occurs in chronic liver disease. Based on their clinical relevance, this review provides a summary of the most common post-translational modifications affecting HSA structural integrity and functions and their clinical relevance in the field of liver disease. The review also provides a critical description of the analytical approaches employed for the investigation of conformational alterations and the identification/quantitation of specific post-translational modifications affecting HSA. Finally, the analytical methods available for the assessment of two of the most clinically relevant non-oncotic properties of HSA, namely the binding capacity and the antioxidant activity, are critically reviewed. Among the available techniques particular attention is given to those proposed for the in vitro and in vivo investigation of structurally modified albumin.
[Mh] Termos MeSH primário: Cirrose Hepática
[Mh] Termos MeSH secundário: Seres Humanos
Oxirredução
Estresse Oxidativo
Processamento de Proteína Pós-Traducional
Albumina Sérica Humana
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:27777202
[Au] Autor:Fan CL; Wu J; Bu XM; Wan SJ; Guo PT; Ma YJ; Wang JJ
[Ad] Endereço:Nanjing Clinical College of Southern Medical University, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China. E-mail: 1204631218@qq.com.
[Ti] Título:[Serum non-esterified fatty acids to albumin ratio increased significantly in children with nephrotic syndrome].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1382-1385, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To analyze serum levels of non-esterified fatty acids (NEFA) and albumin (ALB) in children with nephrotic syndrome (NS) and investigate the clinical significance of altered serum NEFA to ALB ratio in children with NS in acute and remission phases. METHODS: Serum levels of NEFA and ALB were measured in 55 NS children in acute phase, in 33 NS children in remission and in 122 healthy control children, and the ratio of NEFA to ALB was calculated. The other lipid/lipoprotein and renal function parameters were also analyzed in these children. RESULTS: Compared with the healthy control children, children with NS had a significantly decreased serum ALB level (t=11.152, P<0.001) and a significantly increased NEFA to ALB ratio (t=4.991, P<0.001). Compared with NS children in remission, those in acute phase showed a significantly decreased ALB (Z=7.822, P<0.001) and an increased NEFA to ALB ratio (t=4.991, P<0.001). In all the NS children, NEFA to ALB ratio was positively correlated with the levels of TC (r=0.564, P<0.001), TG (r=0.444, P<0.001), LDL-C (r=0.625, P<0.001), urea (r=0.437, P<0.001), creatinine (r=0.278, P=0.013), and uric acid (r=0.397, P<0.001), while negatively correlated with the level of total protein (r=-0.461, P<0.001). Multiple linear regression analyses showed that NEFA to ALB ratio was independently associated with serum urea levels (ß=0.703, P=0.001; adjusted R =0.494) after adjustment of other related factors. CONCLUSION: Serum NEFA to ALB ratio is significantly increased in NS children in close association with impaired kidney function, and may function as a novel parameter for assessing the development of NS.
[Mh] Termos MeSH primário: Ácidos Graxos não Esterificados/sangue
Síndrome Nefrótica/sangue
Albumina Sérica Humana/análise
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Criança
Seres Humanos
Análise de Regressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Nonesterified); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28983724
[Au] Autor:Oh IS; Sinn DH; Kang TW; Lee MW; Kang W; Gwak GY; Paik YH; Choi MS; Lee JH; Koh KC; Paik SW
[Ad] Endereço:Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
[Ti] Título:Liver Function Assessment Using Albumin-Bilirubin Grade for Patients with Very Early-Stage Hepatocellular Carcinoma Treated with Radiofrequency Ablation.
[So] Source:Dig Dis Sci;62(11):3235-3242, 2017 Nov.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Assessment of liver function is essential for management of hepatocellular carcinoma (HCC). Recently, albumin-bilirubin (ALBI) grade has been reported as a useful tool for assessing hepatic reserve in patients with HCC. The objective of this study was to determine whether ALBI grade could be used to predict the overall survival of very early-stage HCC patients treated with radiofrequency ablation (RF ablation). METHODS: A cohort of 368 patients with very early-stage HCC treated with RF ablation was retrospectively analyzed. The overall survival and recurrence-free survival were calculated in groups classified by ALBI grade and Child-Pugh score. RESULTS: Overall survival of patients with ALBI grade 1 was better than that of patients with ALBI grade 2 (5-year survival rate 88.5 vs. 73.8%, P < 0.001). In multivariable-adjusted model, ALBI grade was found to be an independent factor associated with overall survival (hazard ratio 2.44; 95% confidence interval 1.43-4.15). ALBI grade was able to stratify patients with distinct overall survival among patients within the same Child-Pugh score (5-year survival rate for Child-Pugh score 5: 88.5 vs. 76.6%, P = 0.002; for Child-Pugh score 6: 88.9 vs. 70.1%, P = 0.064). In contrast, Child-Pugh score was unable to stratify patients with distinct overall survival within the same ALBI grade. CONCLUSIONS: Among patients with very early-stage HCC treated with RF ablation, ALBI grade was a good stratifying biomarker. ALBI grade was better tool for assessing liver function than Child-Pugh score for very early-stage HCC treated with RF ablation.
[Mh] Termos MeSH primário: Bilirrubina/sangue
Biomarcadores Tumorais/sangue
Carcinoma Hepatocelular/cirurgia
Ablação por Cateter
Testes de Função Hepática/métodos
Neoplasias Hepáticas/cirurgia
Albumina Sérica/análise
[Mh] Termos MeSH secundário: Idoso
Carcinoma Hepatocelular/sangue
Carcinoma Hepatocelular/mortalidade
Carcinoma Hepatocelular/patologia
Ablação por Cateter/efeitos adversos
Ablação por Cateter/mortalidade
Intervalo Livre de Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Neoplasias Hepáticas/sangue
Neoplasias Hepáticas/mortalidade
Neoplasias Hepáticas/patologia
Masculino
Meia-Idade
Análise Multivariada
Estadiamento de Neoplasias
Valor Preditivo dos Testes
Modelos de Riscos Proporcionais
Sistema de Registros
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Albumina Sérica Humana
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ALB protein, human); 0 (Biomarkers, Tumor); 0 (Serum Albumin); RFM9X3LJ49 (Bilirubin); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-017-4775-8


  10 / 854 MEDLINE  
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Fotocópia
[PMID]:28982904
[Au] Autor:Ide S; Toiyama Y; Okugawa Y; Oki S; Yasuda H; Fujikawa H; Yoshiyama S; Hiro J; Kobayashi M; Ohi M; Araki T; Kusunoki M
[Ad] Endereço:Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
[Ti] Título:Clinical Significance of C-Reactive Protein-to-Albumin Ratio with Rectal Cancer Patient Undergoing Chemoradiotherapy Followed by Surgery.
[So] Source:Anticancer Res;37(10):5797-5804, 2017 10.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: This study was designed to evaluate the clinical significance of the C-reactive protein-to-albumin ratio (CAR) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery. PATIENTS AND METHODS: This retrospective study evaluated the correlation between CAR and prognosis in 115 patients with locally advanced rectal cancer. We also carried out subgroup analyses limited to patients with low modified Glasgow prognosis score (mGPS) (score 0) or pathological TNM stage I-II [ypN(-)]. RESULTS: CAR exhibited significant relationships with sex, tumor invasion, recurrence, serum carcinoembryonic antigen, and mGPS. Elevated CAR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) among all patients. Elevated CAR also predicted poor OS and DFS in patients with pathological TNM stage I-II [ypN(-)] and low mGPS score. CONCLUSION: CAR is a promising predictor of survival and recurrence in patients with rectal cancer treated by CRT.
[Mh] Termos MeSH primário: Adenocarcinoma/sangue
Adenocarcinoma/terapia
Biomarcadores Tumorais/sangue
Proteína C-Reativa/metabolismo
Quimiorradioterapia Adjuvante
Procedimentos Cirúrgicos do Sistema Digestório
Terapia Neoadjuvante/mortalidade
Neoplasias Retais/sangue
Neoplasias Retais/terapia
Albumina Sérica/metabolismo
[Mh] Termos MeSH secundário: Adenocarcinoma/mortalidade
Adenocarcinoma/secundário
Idoso
Quimiorradioterapia Adjuvante/efeitos adversos
Quimiorradioterapia Adjuvante/mortalidade
Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos
Procedimentos Cirúrgicos do Sistema Digestório/mortalidade
Progressão da Doença
Intervalo Livre de Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Metástase Linfática
Masculino
Meia-Idade
Terapia Neoadjuvante/efeitos adversos
Recidiva Local de Neoplasia
Estadiamento de Neoplasias
Modelos de Riscos Proporcionais
Neoplasias Retais/mortalidade
Neoplasias Retais/patologia
Estudos Retrospectivos
Fatores de Risco
Albumina Sérica Humana
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ALB protein, human); 0 (Biomarkers, Tumor); 0 (Serum Albumin); 9007-41-4 (C-Reactive Protein); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE



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