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  1 / 6413 MEDLINE  
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[PMID]:29179781
[Au] Autor:Pei R; DiMarco DM; Putt KK; Martin DA; Gu Q; Chitchumroonchokchai C; White HM; Scarlett CO; Bruno RS; Bolling BW
[Ad] Endereço:1Department of Nutritional Sciences,University of Connecticut,3624 Horsebarn Road Extension,Unit 4017,Storrs,CT 06269,USA.
[Ti] Título:Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial.
[So] Source:Br J Nutr;118(12):1043-1051, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The anti-inflammatory mechanisms of low-fat dairy product consumption are largely unknown. The objective of this study was to determine whether low-fat yogurt reduces biomarkers of chronic inflammation and endotoxin exposure in women. Premenopausal women (BMI 18·5-27 and 30-40 kg/m2) were randomised to consume 339 g of low-fat yogurt (yogurt non-obese (YN); yogurt obese (YO)) or 324 g of soya pudding (control non-obese; control obese (CO)) daily for 9 weeks (n 30/group). Fasting blood samples were analysed for IL-6, TNF-α/soluble TNF II (sTNF-RII), high-sensitivity C-reactive protein, 2-arachidonoyl glycerol, anandamide, monocyte gene expression, soluble CD14 (sCD14), lipopolysaccharide (LPS), LPS binding protein (LBP), IgM endotoxin-core antibody (IgM EndoCAb), and zonulin. BMI, waist circumference and blood pressure were also determined. After 9-week yogurt consumption, YO and YN had decreased TNF-α/sTNFR-RII. Yogurt consumption increased plasma IgM EndoCAb regardless of obesity status. sCD14 was not affected by diet, but LBP/sCD14 was lowered by yogurt consumption in both YN and YO. Yogurt intervention increased plasma 2-arachidonoylglycerol in YO but not YN. YO peripheral blood mononuclear cells expression of NF-κB inhibitor α and transforming growth factor ß1 increased relative to CO at 9 weeks. Other biomarkers were unchanged by diet. CO and YO gained approximately 0·9 kg in body weight. YO had 3·6 % lower diastolic blood pressure at week 3. Low-fat yogurt for 9 weeks reduced biomarkers of chronic inflammation and endotoxin exposure in premenopausal women compared with a non-dairy control food. This trial was registered as NCT01686204.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Dieta
Endotoxinas/toxicidade
Inflamação/sangue
Inflamação/dietoterapia
Iogurte/análise
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda
Adulto
Antropometria
Ácidos Araquidônicos/sangue
Proteína C-Reativa/metabolismo
Proteínas de Transporte/sangue
Doença Crônica
Citocinas/sangue
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/análise
Endocanabinoides/sangue
Endotoxemia/sangue
Endotoxemia/dietoterapia
Feminino
Glicerídeos/sangue
Seres Humanos
Imunoglobulina M/sangue
Leucócitos Mononucleares/metabolismo
Glicoproteínas de Membrana/sangue
Meia-Idade
NF-kappa B/metabolismo
Obesidade/metabolismo
Alcamidas Poli-Insaturadas/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Arachidonic Acids); 0 (Biomarkers); 0 (Carrier Proteins); 0 (Cytokines); 0 (Dietary Fats); 0 (Endocannabinoids); 0 (Endotoxins); 0 (Glycerides); 0 (Immunoglobulin M); 0 (Membrane Glycoproteins); 0 (NF-kappa B); 0 (Polyunsaturated Alkamides); 0 (lipopolysaccharide-binding protein); 8D239QDW64 (glyceryl 2-arachidonate); 9007-41-4 (C-Reactive Protein); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003038


  2 / 6413 MEDLINE  
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[PMID]:28464257
[Au] Autor:Pang J; Xu W; Zhang X; Wong GL; Chan AW; Chan HY; Tse CH; Shu SS; Choi PC; Chan HL; Yu J; Wong VW
[Ad] Endereço:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
[Ti] Título:Significant positive association of endotoxemia with histological severity in 237 patients with non-alcoholic fatty liver disease.
[So] Source:Aliment Pharmacol Ther;46(2):175-182, 2017 07.
[Is] ISSN:1365-2036
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients with nonalcoholic steatohepatitis (NASH) have gut dysbiosis and intestinal bacterial overgrowth. AIM: To test the hypothesis that endotoxemia is associated with the histological severity of nonalcoholic fatty liver disease (NAFLD) and determine factors associated with endotoxemia. METHODS: The endotoxemia markers lipopolysaccharide-binding protein (LBP) and endotoxin levels were measured in 237 NAFLD patients 1 day before liver biopsy. Biomarkers of liver injury and transient elastography were performed as additional markers of disease severity. RESULTS: A total of 114/237 (48%) patients had NASH and 80/237 (34%) had F2-4 fibrosis. LBP was correlated with lobular inflammation (P=.001), while both LBP (P=.0004) and endotoxin levels (P=0.008) were correlated with fibrosis. LBP was also correlated with cytokeratin-18 fragments (P=.002) and aspartate aminotransferase-to-alanine aminotransferase ratio (P=.006), and both LBP (P=.019) and endotoxin (P=.006) were correlated with liver stiffness measurement by transient elastography. LBP was increased in patients with NASH (15.3±4.6 vs 13.8±3.3 µg/mL; P=.005) and F2-4 fibrosis (15.4±4.4 vs 14.0±3.7 µg/mL; P=.008). Interestingly, patients harbouring the TM6SF2 rs58542926 T allele that predispose to NAFLD/NASH had higher LBP level. By multivariate analysis, gender, higher body mass index and glycated haemoglobin, and TM6SF2 variants were independent factors associated with increased LBP level. CONCLUSIONS: Endotoxemia is positively associated with NASH and significant fibrosis. The association between TM6SF2 and endotoxemia warrants further investigations. The findings may shed light on the pathogenesis of NASH and inform a novel treatment target.
[Mh] Termos MeSH primário: Endotoxemia/epidemiologia
Hepatopatia Gordurosa não Alcoólica/epidemiologia
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda
Adulto
Idoso
Alelos
Biomarcadores
Biópsia
Índice de Massa Corporal
Proteínas de Transporte/sangue
Feminino
Fibrose
Seres Humanos
Intestinos/microbiologia
Queratina-18/sangue
Fígado/patologia
Masculino
Glicoproteínas de Membrana/sangue
Meia-Idade
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Biomarkers); 0 (Carrier Proteins); 0 (Keratin-18); 0 (Membrane Glycoproteins); 0 (lipopolysaccharide-binding protein)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/apt.14119


  3 / 6413 MEDLINE  
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[PMID]:28981818
[Au] Autor:Shiels MS; Shu XO; Chaturvedi AK; Gao YT; Xiang YB; Cai Q; Hu W; Shelton G; Ji BT; Pinto LA; Kemp TJ; Rothman N; Zheng W; Hildesheim A; Lan Q
[Ad] Endereço:Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
[Ti] Título:A prospective study of immune and inflammation markers and risk of lung cancer among female never smokers in Shanghai.
[So] Source:Carcinogenesis;38(10):1004-1010, 2017 Oct 01.
[Is] ISSN:1460-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is a paucity of data on risk factors for lung cancer among never smokers. Here, we have carried out the first large study of circulating inflammation markers and lung cancer risk among female never smokers in Shanghai. A study of 248 lung cancer cases in female never smokers and 263 controls was nested within the Shanghai Women's Health Study (n = 75221), matched by dates of birth and blood collection (mean follow-up time = 7.5 years). Prediagnostic plasma levels of 65 inflammation markers were measured using a Luminex bead-based assay. Odds ratios (ORs) were estimated with multivariable logistic regression. Nine of 61 evaluable markers were statistically significantly associated with lung cancer risk among never smoking Chinese women (P-trend across categories <0.05). Soluble interleukin-6 receptor [sIL-6R; highest versus lowest category OR = 2.37; 95% confidence interval (CI) 1.40-4.02) and chemokine (C-C motif) ligand 2/monocyte chemotactic protein 1; (OR = 1.62; 95% CI 0.94-2.80) were associated with an increased risk of lung cancer, whereas interleukin (IL)-21 (OR = 0.53; 95%CI 0.31-0.93), chemokine (C-X3-C motif) ligand 1/fractalkine (OR = 0.54; 95% CI 0.30-0.96), soluble vascular endothelial growth factor receptor 2 (sVEGFR2, OR = 0.45; 95% CI 0.26-0.76), sVEGFR3 (OR = 0.53; 95% CI 0.32-0.90), soluble tumor necrosis factor receptor I (OR = 0.49; 95% CI 0.29-0.83), IL-10 (OR = 0.60; 95% CI 0.34-1.05) and C-reactive protein (OR = 0.63; 95% CI 0.37-1.06) were associated with a decreased risk. sIL-6R remained significantly associated with lung cancer risk >7.5 years prior to diagnosis. Markers involved in various aspects of the immune response were associated with subsequent lung cancer risk, implicating inflammation in the etiology of lung cancer among female never smokers.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Inflamação/metabolismo
Neoplasias Pulmonares/etiologia
Fumar/efeitos adversos
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda/análise
Adulto
Idoso
Biomarcadores/metabolismo
Biomarcadores Tumorais/sangue
Biomarcadores Tumorais/metabolismo
Estudos de Casos e Controles
Quimiocina CX3CL1/sangue
Quimiocinas/sangue
China
Citocinas/sangue
Feminino
Seres Humanos
Inflamação/imunologia
Neoplasias Pulmonares/imunologia
Meia-Idade
Estudos Prospectivos
Receptores de Interleucina-6/sangue
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Biomarkers); 0 (Biomarkers, Tumor); 0 (CX3CL1 protein, human); 0 (Chemokine CX3CL1); 0 (Chemokines); 0 (Cytokines); 0 (Receptors, Interleukin-6)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1093/carcin/bgx075


  4 / 6413 MEDLINE  
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[PMID]:28880885
[Au] Autor:Nier A; Engstler AJ; Maier IB; Bergheim I
[Ad] Endereço:Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.
[Ti] Título:Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children.
[So] Source:PLoS One;12(9):e0183282, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without beginning fibrosis frequently show altered fecal microbiota composition and elevated bacterial endotoxin levels. However, if these alterations are signs of a progressing disease or are already found in initial disease stages has not yet been clarified. METHODS: Twenty children with simple steatosis (grade 1) diagnosed by ultrasound and 29 normal weight healthy control children (age <10 years) were included in the study (mean age 7.6 ± 1.1 years). Metabolic parameters, markers of intestinal barrier function and inflammation were determined. RESULTS: Activity of alanine aminotransferase, concentrations of some markers of inflammation and insulin resistance were significantly higher in plasma of NAFLD children than in controls. When compared to controls, plasma bacterial endotoxin and lipopolysaccharide-binding protein (LBP) levels were significantly higher in NAFLD children (+50% and +24%, respectively), while soluble CD14 serum and D-lactate plasma levels as well as the prevalence of small intestinal bacterial overgrowth did not differ between groups. Plasma endotoxin and LBP levels were positive associated with proinflammatory markers like plasminogen activator inhibitor-1, c-reactive protein, interleukin-6 and leptin while no associations with markers of insulin resistance were found. CONCLUSIONS: Taken together, our results indicate that even in juvenile patients with early stages of NAFLD e.g. simple steatosis grade 1, plasma endotoxin concentrations are already elevated further suggesting that intestinal barrier dysfunction might be present already in the initial phases of the disease.
[Mh] Termos MeSH primário: Hepatopatia Gordurosa não Alcoólica/sangue
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda
Adolescente
Alanina Transaminase/sangue
Proteínas de Transporte/sangue
Criança
Endotoxinas/sangue
Fígado Gorduroso/sangue
Fígado Gorduroso/imunologia
Feminino
Seres Humanos
Inflamação/sangue
Inflamação/imunologia
Resistência à Insulina/imunologia
Ácido Láctico/sangue
Receptores de Lipopolissacarídeos/sangue
Masculino
Glicoproteínas de Membrana/sangue
Hepatopatia Gordurosa não Alcoólica/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Carrier Proteins); 0 (Endotoxins); 0 (Lipopolysaccharide Receptors); 0 (Membrane Glycoproteins); 0 (lipopolysaccharide-binding protein); 33X04XA5AT (Lactic Acid); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183282


  5 / 6413 MEDLINE  
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[PMID]:28759613
[Au] Autor:Muhammad IF; Borné Y; Östling G; Kennbäck C; Gottsäter M; Persson M; Nilsson PM; Engström G
[Ad] Endereço:Department of Clinical Sciences, Lund University, Malmö, Sweden.
[Ti] Título:Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort.
[So] Source:PLoS One;12(7):e0181718, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. METHOD: The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991-1994) and follow-up examinations (2007-2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV. RESULTS: After adjusting for traditional risk factors the participants in the 4th quartile vs 1st quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (p<0.05), C3 (10.35 m/s vs 10.06 m/s) (p<0.05) and CRP (10.37 m/s vs 9.96 m/s) (p<0.001) showed significant association with c-f PWV. Diabetes at follow-up was also associated with high c-f PWV, however, this relationship was independent of low grade inflammation. CONCLUSION: Alpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.
[Mh] Termos MeSH primário: Proteínas da Fase Aguda/análise
Artérias/fisiopatologia
Doenças Cardiovasculares/sangue
Rigidez Vascular
[Mh] Termos MeSH secundário: Idoso
Proteína C-Reativa/análise
Doenças Cardiovasculares/epidemiologia
Ceruloplasmina/análise
Estudos de Coortes
Complemento C3/análise
Feminino
Seguimentos
Haptoglobinas/análise
Seres Humanos
Inflamação
Modelos Lineares
Masculino
Meia-Idade
Orosomucoide/análise
Estudos Prospectivos
Análise de Onda de Pulso
Fatores de Risco
alfa 1-Antitripsina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Complement C3); 0 (HP protein, human); 0 (Haptoglobins); 0 (Orosomucoid); 0 (alpha 1-Antitrypsin); 9007-41-4 (C-Reactive Protein); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181718


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[PMID]:28755024
[Au] Autor:Kimura K; Orita T; Kobayashi Y; Matsuyama S; Fujimoto K; Yamauchi K
[Ad] Endereço:Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan. k.kimura@yamaguchi-u.ac.jp.
[Ti] Título:Concentration of acute phase factors in vitreous fluid in diabetic macular edema.
[So] Source:Jpn J Ophthalmol;61(6):479-483, 2017 Nov.
[Is] ISSN:1613-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy. STUDY DESIGN: Retrospective. METHODS: Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane. The concentrations of acute phase factors (α2-macroglobulin, haptoglobin, C-reactive protein, serum amyloid P and A, procalcitonin, ferritin, tissue plasminogen activator, fibrinogen) and vascular endothelial growth factor (VEGF) were measured with multiplex assays. CRT of macular edema was measured by optical coherence tomography (OCT). RESULTS: The levels of serum amyloid P, procalcitonin, ferritin, and fibrinogen in vitreous fluid were increased in DME patients compared with control subjects. The levels of procalcitonin and fibrinogen in DME patients were inversely correlated with visual acuity both before and 3 months after vitrectomy but not 6 months postsurgery. The concentrations of these four factors were not correlated with either CRT or the vitreous levels of VEGF in DME patients. CONCLUSION: Acute phase factors may contribute to local inflammation in DME and may therefore influence disease progression.
[Mh] Termos MeSH primário: Proteínas da Fase Aguda/metabolismo
Retinopatia Diabética/metabolismo
Edema Macular/metabolismo
Corpo Vítreo/metabolismo
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/metabolismo
Retinopatia Diabética/complicações
Retinopatia Diabética/diagnóstico
Feminino
Seres Humanos
Imunoensaio
Edema Macular/diagnóstico
Edema Macular/etiologia
Masculino
Meia-Idade
Retina/patologia
Estudos Retrospectivos
Tomografia de Coerência Óptica/métodos
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Biomarkers)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170730
[St] Status:MEDLINE
[do] DOI:10.1007/s10384-017-0525-x


  7 / 6413 MEDLINE  
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[PMID]:28715154
[Au] Autor:Plotnikov EY; Pavlenko TA; Pevzner IB; Zorova LD; Manskikh VN; Silachev DN; Sukhikh GT; Zorov DB
[Ad] Endereço:A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Russia.
[Ti] Título:The role of oxidative stress in acute renal injury of newborn rats exposed to hypoxia and endotoxin.
[So] Source:FEBS J;284(18):3069-3078, 2017 Sep.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neonatal kidney injury is a frequent pathology, especially among premature infants. The search for effective nephroprotection requires the creation of adequate experimental models of nephropathy in newborns. In this study, we explored the development of acute kidney injury (AKI) in neonatal rats during hypoxia or administration of endotoxin. We found that 2-h hypoxia (8% O ) and the intraperitoneal injection of 4 mg·kg lipopolysaccharide (LPS) causes the appearance of AKI markers, such as kidney injury molecule-1 (КIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the rat urine after 24 and 72 h of exposure. On the other hand, the levels of blood urine nitrogen under the same conditions rise only slightly. The damaging effects of hypoxia and endotoxin were accompanied by histological changes in the renal tissue and a significant decrease in the proliferation marker, (proliferating cell nuclear antigen). It is revealed that 3 h after the introduction of LPS, levels of reactive oxygen species in the kidney were significantly increased, and the injection of the antioxidant N-acetylcysteine afforded protection from AKI, evaluated by urine КIM-1 and NGAL levels. Thus, the simulation of AKI in newborn rat pups can be employed in screening for potential nephroprotective drugs, particularly among antioxidative compounds to be used in neonatology.
[Mh] Termos MeSH primário: Lesão Renal Aguda/genética
Proteínas da Fase Aguda/genética
Moléculas de Adesão Celular/genética
Hipóxia/genética
Lipocalinas/genética
Proteínas Proto-Oncogênicas/genética
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Acetilcisteína/farmacologia
Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/patologia
Lesão Renal Aguda/prevenção & controle
Proteínas da Fase Aguda/urina
Animais
Animais Recém-Nascidos
Antioxidantes/farmacologia
Biomarcadores/urina
Nitrogênio da Ureia Sanguínea
Moléculas de Adesão Celular/urina
Modelos Animais de Doenças
Expressão Gênica
Seres Humanos
Hipóxia/patologia
Lactente
Lipocalinas/urina
Lipopolissacarídeos
Estresse Oxidativo/efeitos dos fármacos
Antígeno Nuclear de Célula em Proliferação/genética
Antígeno Nuclear de Célula em Proliferação/metabolismo
Proteínas Proto-Oncogênicas/urina
Ratos
Espécies Reativas de Oxigênio/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Antioxidants); 0 (Biomarkers); 0 (Cell Adhesion Molecules); 0 (Havcr1protein, rat); 0 (Lipocalins); 0 (Lipopolysaccharides); 0 (Proliferating Cell Nuclear Antigen); 0 (Proto-Oncogene Proteins); 0 (Reactive Oxygen Species); 0 (neutrophil gelatinase-associated lipocalin protein, rat); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1111/febs.14177


  8 / 6413 MEDLINE  
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[PMID]:28662411
[Au] Autor:Zhao Y; Wu X; Qian L; Guo L; Liao J; Wu X
[Ad] Endereço:Department of Respiratory Medicine, Punan hospital of Pudong New District, Shanghai, China.
[Ti] Título:Activating transcription factor 3 protects mice against pseudomonas aeruginosa-induced acute lung injury by interacting with lipopolysaccharide binding protein.
[So] Source:Mol Immunol;90:27-32, 2017 Oct.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Excessive inflammatory response is critical event in the pathogenesis of acute lung injury (ALI). Previous study has shown that activating transcription factor 3 (ATF3) plays a role in downregulate inflammatory responses including ventilation-induced ALI. We hypothesized that ATF3 have a protective effect in ALI induced by pseudomonas aeruginosa. PA was intra-tracheally administrated to ATF3 knock-out (KO) mice to establish ALI model. Inflammatory factors, BALF protein, lung wet to dry ratio, lung injury score and mortality were determined. The activation of NF-κB was detected by western blot and Co-immunoprecipitation (Co-ip) was used to determinate the binding of ATF3 to LBP. Peritoneal macrophages were isolated from ATF3 KO mice and stimulated by PA. PA increased the expression of ATF3 in the lung tissues in ATF3 wild type (WT) mice. ATF3 deficiency significantly increased the concentration of TNFα, IL-6 and IL-1ß in the supernatant of peritoneal macrophages, lung tissue and BALF after PA stimulation and also enhanced the activity of NF-κB. ATF3 deficiency also enhanced the BALF protein concentration and increased the lung wet to dry ratio. The lung injury score and mortality were higher in ATF3 KO mice treated with PA. Moreover, ATF3 was demonstrated to bind to LBP These finding suggest ATF3 protect mice against ALI induced by PA partly due to the binding to LBP.
[Mh] Termos MeSH primário: Fator 3 Ativador da Transcrição/metabolismo
Lesão Pulmonar Aguda/prevenção & controle
Proteínas da Fase Aguda/metabolismo
Proteínas de Transporte/metabolismo
Macrófagos Peritoneais/imunologia
Glicoproteínas de Membrana/metabolismo
Infecções por Pseudomonas/prevenção & controle
[Mh] Termos MeSH secundário: Fator 3 Ativador da Transcrição/genética
Lesão Pulmonar Aguda/microbiologia
Animais
Líquido da Lavagem Broncoalveolar/química
Células Cultivadas
Interleucina-1beta/metabolismo
Interleucina-6/metabolismo
Pulmão/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
NF-kappa B/metabolismo
Infecções por Pseudomonas/microbiologia
Pseudomonas aeruginosa/imunologia
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Activating Transcription Factor 3); 0 (Acute-Phase Proteins); 0 (Atf3 protein, mouse); 0 (Carrier Proteins); 0 (IL1B protein, mouse); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Membrane Glycoproteins); 0 (NF-kappa B); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); 0 (lipopolysaccharide-binding protein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE


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[PMID]:28615259
[Au] Autor:Namaste SM; Rohner F; Huang J; Bhushan NL; Flores-Ayala R; Kupka R; Mei Z; Rawat R; Williams AM; Raiten DJ; Northrop-Clewes CA; Suchdev PS
[Ad] Endereço:Strengthening Partnerships, Results, and Innovations in Nutrition Globally, Arlington, VA; sorrelnamaste@gmail.com.
[Ti] Título:Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):359S-371S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The accurate estimation of iron deficiency is important in planning and implementing interventions. Ferritin is recommended as the primary measure of iron status, but interpretability is challenging in settings with infection and inflammation. We assessed the relation between ferritin concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and investigated adjustment algorithms to account for these effects. Cross-sectional data from 15 surveys for PSC ( = 27,865) and 8 surveys for WRA (24,844), from the Biomarkers Reflecting the Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and combined with the use of a meta-analysis. Several approaches were explored to estimate depleted iron stores (ferritin concentration <12 µg/L in PSC and <15 µg/L in WRA) in inflammation and malaria settings as follows: ) increase ferritin-concentration cutoff to <30 µg/L; ) exclude individuals with C-reactive protein (CRP) concentrations >5 mg/L or α-1-acid glycoprotein (AGP) concentrations >1 g/L; ) apply arithmetic correction factors; and ) use a regression correction approach. Depleted iron-store estimates incrementally increased as CRP and AGP deciles decreased (4% compared with 30%, and 6% compared with 29% from highest compared with lowest CRP deciles for pooled PSC and WRA, respectively, with similar results for AGP). Depending on the approach used to adjust for inflammation (CRP plus AGP), the estimated prevalence of depleted iron stores increased by 7-25 and 2-8 absolute median percentage points for PSC and WRA, respectively, compared with unadjusted values. Adjustment for malaria in addition to CRP and AGP did not substantially change the estimated prevalence of depleted iron stores. Our results lend support for the use of internal regression correction to estimate the prevalence of depleted iron stores in regions with inflammation. This approach appears to mathematically reflect the linear relation of ferritin concentrations with acute-phase proteins. More research is warranted to validate the proposed approaches, but this study contributes to the evidence base to guide decisions about how and when to adjust ferritin for inflammation.
[Mh] Termos MeSH primário: Anemia/sangue
Biomarcadores/sangue
Ferritinas/sangue
Inflamação/sangue
Estado Nutricional
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda/análise
Adolescente
Adulto
Proteína C-Reativa
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Ferro/deficiência
Malária/sangue
Meia-Idade
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Biomarkers); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.141762


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[PMID]:28594948
[Au] Autor:Gutiérrez AM; De La Cruz-Sánchez E; Montes A; Sotillo J; Gutiérrez-Panizo C; Fuentes P; Tornel PL; Cabezas-Herrera J
[Ad] Endereço:Department of Animal Medicine and Surgery, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Espinardo, Murcia, Spain.
[Ti] Título:Easy and non-invasive disease detection in pigs by adenosine deaminase activity determinations in saliva.
[So] Source:PLoS One;12(6):e0179299, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The quantification of adenosine deaminase (ADA) in porcine saliva samples has been analyzed for its use as a marker of disease. First, an analytical validation of the enzymatic assay used for ADA measurements was performed. Afterwards, saliva samples were collected from 50 healthy animals and 64 animals with different symptoms of disease, which were divided into local inflammation, gastrointestinal disorder, respiratory disorder and growth retardation. To optimize ADA measurements, total ADA (tADA), specific ADA (sADA) and ADA isoforms 1 and 2 activities were calculated. Moreover, to preliminarily estimate the diagnostic value of tADA activity measurements for disease detection, receiver operating characteristic (ROC) analyses was performed and compared to the results obtained for salivary acute phase proteins, haptoglobin (Hp) and C-reactive protein (CRP). The salivary levels of tADA activity were significantly elevated in animals with local inflammation, gastrointestinal disorder and respiratory disorder. The calculation of the different ADA activities did not provide additional information to tADA activity quantification for disease detection. The diagnostic value of tADA activity was superior to those observed for Hp and CRP measurements in the present study. It might be concluded that ADA analysis in saliva could be used as a simple, rapid, economic and non-invasive diagnostic tool in porcine production in field conditions.
[Mh] Termos MeSH primário: Adenosina Desaminase/metabolismo
Saliva/enzimologia
Saliva/metabolismo
Doenças dos Suínos/enzimologia
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda/metabolismo
Animais
Proteína C-Reativa/metabolismo
Modelos Lineares
Curva ROC
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Sus scrofa
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 9007-41-4 (C-Reactive Protein); EC 3.5.4.4 (Adenosine Deaminase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179299



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