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[PMID]: | 27777195 |
[Au] Autor: | Chen S; Ma BL; Cao MQ; Yu HJ; Ma XM |
[Ad] Endereço: | 1School of Basic Medicine, Lanzhou University, Lanzhou 730030, China; 2Second Hospital of Lanzhou University, Lanzhou 730030, China. E-mail: lncsi@126.com. |
[Ti] Título: | [Correlation among serum MBL, MASP-2, HsCRP and C levels in rheumatoid arthritis]. |
[So] Source: | Nan Fang Yi Ke Da Xue Xue Bao;36(10):1340-1344, 2016 Oct 20. | [Is] ISSN: | 1673-4254 |
[Cp] País de publicação: | China |
[La] Idioma: | chi |
[Ab] Resumo: | OBJECTIVE: To investigate the correlation among serum levels of manning-binding lectin (MBL), MBL-associated serine proteases-2 (MASP-2), complement C and high-sensitive C reactive protein (HsCRP) in patients with rheumatoid arthritis (RA). METHODS: Fasting venous blood were collected from 50 RA patients (25 in active stage and 25 in remission) and 40 healthy subjects for detecting serum levels of MBL, MASP-2, complement C and HsCRP using enzyme-linked immunosorbent assay (ELISA) and immune turbidity assay. RESULTS: The serum levels of MBL and MASP-2 were significantly lower and HsCRP level was significantly higher in patients with RA (in both acute stage and remission) than in the healthy control group (P<0.05), but complement C level was similar between the RA patients and control group. Bivariate Pearson correlation analysis showed that in RA patients, MBL was positively correlated with MASP-2 level (r=0.550, P=0.001) and negatively with HsCRP (r=-0.323, P=0.022) but not correlated with C (r=-0.022, P=0.882); MASP-2 was negatively correlated with HsCRP (r=0.453, P=0.453) and was not correlated with C (r=0.049, P=0.738). ROC curve analysis revealed the largest area under curve (AUC) of HsCRP (0.844, P=0.001) and smaller AUCs of MBL (0.025, P=0.001) and MASP-2 (0.266, P=0.001). HsCRP had a much higher sensitivity (84%) than MBL (10%) and MASP-2 (40%) in the diagnosis of RA. CONCLUSION: In RA patients, MBL and MASP-2 are negatively correlated with HsCRP level. Serum MBL and MASP-2 levels decrease with the progression of joint injury in RA patients, suggesting their involvement in the pathological process of RA; but due to their low sensitivity, they are not appropriate indicators for evaluating the disease activity of RA. |
[Mh] Termos MeSH primário: |
Artrite Reumatoide/sangue Proteína C-Reativa/análise Complemento C3/análise Lectina de Ligação a Manose/sangue Serina Proteases Associadas a Proteína de Ligação a Manose/análise
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[Mh] Termos MeSH secundário: |
Estudos de Casos e Controles Ensaio de Imunoadsorção Enzimática Seres Humanos
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (C3 protein, human); 0 (Complement C3); 0 (Mannose-Binding Lectin); 9007-41-4 (C-Reactive Protein); EC 3.4.21.- (MASP2 protein, human); EC 3.4.21.- (Mannose-Binding Protein-Associated Serine Proteases) |
[Em] Mês de entrada: | 1711 |
[Cu] Atualização por classe: | 171128 |
[Lr] Data última revisão:
| 171128 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161026 |
[St] Status: | MEDLINE |
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