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[PMID]:29189196
[Au] Autor:Diana A; Haszard JJ; Purnamasari DM; Nurulazmi I; Luftimas DE; Rahmania S; Nugraha GI; Erhardt J; Gibson RS; Houghton L
[Ad] Endereço:1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia.
[Ti] Título:Iron, zinc, vitamin A and selenium status in a cohort of Indonesian infants after adjusting for inflammation using several different approaches.
[So] Source:Br J Nutr;118(10):830-839, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inflammation confounds the interpretation of several micronutrient biomarkers resulting in estimates that may not reflect the true burden of deficiency. We aimed to assess and compare the micronutrient status of a cohort of Indonesian infants (n 230) at aged 6, 9 and 12 months by ignoring inflammation (unadjusted) and adjusting four micronutrient biomarkers for inflammation with C-reactive protein (CRP) and α-1-glycoprotein (AGP) using the following methods: (1) arithmetic correction factors with the use of a four-stage inflammation model; and (2) regression modelling. Prevalence of infants with any inflammation (CRP>5 mg/l and/or AGP>1 g/l) was about 25% at each age. Compared with unadjusted values, regression adjustment at 6, 9 and 12 months generated the lowest (P50 % across all ages. In conclusion, without inflammation adjustment, Fe deficiency was grossly under-estimated and vitamin A and Zn deficiency over-estimated, highlighting the importance of correcting for the influence of such, before implementing programmes to alleviate micronutrient malnutrition. However, further work is needed to validate the proposed approaches with a particular focus on assessing the influence of varying degrees of inflammation (i.e. recurrent acute infections and low-grade chronic inflammation) on each affected nutrient biomarker.
[Mh] Termos MeSH primário: Deficiências Nutricionais/sangue
Inflamação/sangue
Ferro/sangue
Estado Nutricional
Selênio/sangue
Vitamina A/sangue
Zinco/sangue
[Mh] Termos MeSH secundário: Anemia Ferropriva/sangue
Anemia Ferropriva/epidemiologia
Biomarcadores/sangue
Proteína C-Reativa/metabolismo
Estudos de Coortes
Estudos Transversais
Deficiências Nutricionais/epidemiologia
Feminino
Ferritinas/sangue
Seres Humanos
Indonésia/epidemiologia
Lactente
Inflamação/complicações
Inflamação/epidemiologia
Ferro/deficiência
Masculino
Micronutrientes/sangue
Orosomucoide/metabolismo
Prevalência
Proteínas de Ligação ao Retinol/metabolismo
Selênio/deficiência
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/epidemiologia
Zinco/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002860


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[PMID]:28782526
[Au] Autor:Erba E; Romano M; Gobbi M; Zucchetti M; Ferrari M; Matteo C; Panini N; Colmegna B; Caratti G; Porcu L; Fruscio R; Perlangeli MV; Mezzanzanica D; Lorusso D; Raspagliesi F; D'Incalci M
[Ad] Endereço:Department of Oncology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy.
[Ti] Título:Ascites interferes with the activity of lurbinectedin and trabectedin: Potential role of their binding to alpha 1-acid glycoprotein.
[So] Source:Biochem Pharmacol;144:52-62, 2017 Nov 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trabectedin and its analogue lurbinectedin are effective drugs used in the treatment of ovarian cancer. Since the presence of ascites is a frequent event in advanced ovarian cancer we asked the question whether ascites could modify the activity of these compounds against ovarian cancer cells. The cytotoxicity induced by trabectedin or lurbinectedin against A2780, OVCAR-5 cell lines or primary culture of human ovarian cancer cells was compared by performing treatment in regular medium or in ascites taken from either nude mice or ovarian cancer patients. Ascites completely abolished the activity of lurbinectedin at up to 10nM (in regular medium corresponds to the IC90), strongly reduced that of trabectedin, inhibited the cellular uptake of lurbinectedin and, to a lesser extent, that of trabectedin. Since α1-acid glycoprotein (AGP) is present in ascites at relatively high concentrations, we tested if the binding of the drugs to this protein could be responsible for the reduction of their activity. Adding AGP to the medium at concentration range of those found in ascites, we reproduced the anticytotoxic effect of ascites. Erythromycin partially restored the activity of the drugs, presumably by displacing them from AGP. Equilibrium dialysis experiments showed that both drugs bind AGP, but the affinity of binding of lurbinectedin was much greater than that of trabectedin. KD values are 8±1.7 and 87±14nM for lurbinectedin and trabectedin, respectively. The studies intimate the possibility that AGP present in ascites might reduce the activity of lurbinectedin and to a lesser extent of trabectedin against ovarian cancer cells present in ascites. AGP plasma levels could influence the distribution of these drugs and thus they should be monitored in patients receiving these compounds.
[Mh] Termos MeSH primário: Ascite/metabolismo
Carbolinas/metabolismo
Dioxóis/metabolismo
Compostos Heterocíclicos de 4 ou mais Anéis/metabolismo
Orosomucoide/metabolismo
Neoplasias Ovarianas/metabolismo
Tetra-Hidroisoquinolinas/metabolismo
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Alquilantes/metabolismo
Antineoplásicos Alquilantes/farmacologia
Antineoplásicos Alquilantes/uso terapêutico
Carbolinas/farmacologia
Carbolinas/uso terapêutico
Linhagem Celular Tumoral
Dioxóis/farmacologia
Dioxóis/uso terapêutico
Relação Dose-Resposta a Droga
Feminino
Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Compostos Heterocíclicos de 4 ou mais Anéis/uso terapêutico
Seres Humanos
Camundongos
Camundongos Nus
Neoplasias Ovarianas/tratamento farmacológico
Neoplasias Ovarianas/cirurgia
Ligação Proteica/fisiologia
Tetra-Hidroisoquinolinas/farmacologia
Tetra-Hidroisoquinolinas/uso terapêutico
Células Tumorais Cultivadas
Ensaios Antitumorais Modelo de Xenoenxerto/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 0 (Carbolines); 0 (Dioxoles); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Orosomucoid); 0 (PM 01183); 0 (Tetrahydroisoquinolines); ID0YZQ2TCP (trabectedin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE


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[PMID]:28759613
[Au] Autor:Muhammad IF; Borné Y; Östling G; Kennbäck C; Gottsäter M; Persson M; Nilsson PM; Engström G
[Ad] Endereço:Department of Clinical Sciences, Lund University, Malmö, Sweden.
[Ti] Título:Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort.
[So] Source:PLoS One;12(7):e0181718, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. METHOD: The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991-1994) and follow-up examinations (2007-2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV. RESULTS: After adjusting for traditional risk factors the participants in the 4th quartile vs 1st quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (p<0.05), C3 (10.35 m/s vs 10.06 m/s) (p<0.05) and CRP (10.37 m/s vs 9.96 m/s) (p<0.001) showed significant association with c-f PWV. Diabetes at follow-up was also associated with high c-f PWV, however, this relationship was independent of low grade inflammation. CONCLUSION: Alpha-1-antitrypsin, C3 and CRP are associated with arterial stiffness. The results indicate that low grade inflammation is associated with arterial stiffness in addition to established cardiovascular risk factors.
[Mh] Termos MeSH primário: Proteínas da Fase Aguda/análise
Artérias/fisiopatologia
Doenças Cardiovasculares/sangue
Rigidez Vascular
[Mh] Termos MeSH secundário: Idoso
Proteína C-Reativa/análise
Doenças Cardiovasculares/epidemiologia
Ceruloplasmina/análise
Estudos de Coortes
Complemento C3/análise
Feminino
Seguimentos
Haptoglobinas/análise
Seres Humanos
Inflamação
Modelos Lineares
Masculino
Meia-Idade
Orosomucoide/análise
Estudos Prospectivos
Análise de Onda de Pulso
Fatores de Risco
alfa 1-Antitripsina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Complement C3); 0 (HP protein, human); 0 (Haptoglobins); 0 (Orosomucoid); 0 (alpha 1-Antitrypsin); 9007-41-4 (C-Reactive Protein); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181718


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[PMID]:28646836
[Au] Autor:Lenártová P; Kopceková J; Gazarová M; Mrázová J; Wyka J
[Ad] Endereço:Slovak University of Agriculture in Nitra, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Nitra, Slovakia
[Ti] Título:Biochemical parameters as monitoring markers of the inflammatory reaction by patients with chronic obstructive pulmonary disease (COPD)
[So] Source:Rocz Panstw Zakl Hig;68(2):185-190, 2017.
[Is] ISSN:0035-7715
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Background: Chronic obstructive pulmonary disease (COPD) is an airway inflammatory disease caused by inhalation of toxic particles, mainly cigarette smoking, and now is accepted as a disease associated with systemic characteristics. Objective: The aim of this work was to investigate and compare selected biochemical parameters in patients with and without COPD. Material and Methods: Observation group consisted of clinically stable patients with COPD (n = 60). The control group was healthy persons from the general population, without COPD, who were divided into two subgroups ­ smokers (n = 30) and non-smokers (n = 30). Laboratory parameters were investigated by automated clinical chemistry analyzer LISA 200th. Results: Albumin in our measurements showed an average value of 39.55 g.l-1 in the patient population; 38.89 g.l-1 in smokers and in non-smokers group 44.65 g.l-1. The average value of pre-albumin in the group of patients was 0.28 ± 0.28 g.l-1 and 0.30 ± 0.04 g.l-1 in smokers group. The average value of the orosomucoid in patients was about 1.11 ± 0.90 mg.ml-1. In the group of smokers, the mean value of orosomucoid was 0.60 ± 0.13 mg.ml-1. The level of C-reactive protein (CRP) in the patient group reached an average value of 15.31 ± 22.04 mg.l-1, in the group of smokers was 5.18 ± 4.58 mg. l-1. Prognostic inflammatory and nutritional index (PINI) in the group of patients showed a mean value of 4.65 ± 10.77 and 0.026 ± 0.025 in smokers. Conclusions: The results of this work show, that the values of index PINI in COPD patients are significantly higher than in smokers (P <0.001). This along with other monitored parameters indicative inflammation as well as a catabolic process that occurs in the organism of patients with COPD.
[Mh] Termos MeSH primário: Proteína C-Reativa/análise
Inflamação
Orosomucoide/análise
Doença Pulmonar Obstrutiva Crônica/sangue
[Mh] Termos MeSH secundário: Biomarcadores
Feminino
Seres Humanos
Masculino
Doença Pulmonar Obstrutiva Crônica/etiologia
Doença Pulmonar Obstrutiva Crônica/imunologia
Fumar/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


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[PMID]:28615263
[Au] Autor:Merrill RD; Burke RM; Northrop-Clewes CA; Rayco-Solon P; Flores-Ayala R; Namaste SM; Serdula MK; Suchdev PS
[Ad] Endereço:Nutrition Branch, CDC, Atlanta, GA; rdaymerrill@cdc.gov psuchde@emory.edu.
[Ti] Título:Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):348S-358S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In many settings, populations experience recurrent exposure to inflammatory agents that catalyze fluctuations in the concentrations of acute-phase proteins and certain micronutrient biomarkers such as C-reactive protein (CRP), α-1-acid glycoprotein (AGP), ferritin, and retinol. Few data are available on the prevalence and predictors of inflammation in diverse settings. We aimed to assess the relation between inflammation (CRP concentration >5 mg/L or AGP concentration >1 g/L) and covariates, such as demographics, reported illness, and anthropometric status, in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y). Cross-sectional data from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project from 29,765 PSC in 16 surveys and 25,731 WRA in 10 surveys were used to model bivariable and multivariable relations. The inflammation prevalence was 6.0-40.2% in PSC and 7.9-29.5% in WRA (elevated CRP) and 21.2-64.3% in PSC and 7.1-26.7% in WRA (elevated AGP). In PSC, inflammation was consistently positively associated with recent fever and malaria but not with other recent illnesses. In multivariable models that were adjusted for age, sex, urban or rural residence, and socioeconomic status, elevated AGP was positively associated with stunting (height-for-age score <-2) in 7 of 10 surveys. In WRA, elevated CRP was positively associated with obesity [body mass index (in kg/m ) ≥30] in 7 of 9 surveys. Other covariates showed inconsistent patterns of association with inflammation. In a pooled analysis of surveys that measured malaria, stunting was associated with elevated AGP but not CRP in PSC, and obesity was associated with both elevated CRP and AGP in WRA. Recent morbidity and abnormal anthropometric status are consistently associated with inflammation across a range of environments, whereas more commonly collected demographic covariates were not. Because of the challenge of defining a general demographic population or environmental profile that is more likely to experience inflammation, inflammatory markers should be measured in surveys to account for their effects.
[Mh] Termos MeSH primário: Anemia/diagnóstico
Biomarcadores/análise
Inflamação/diagnóstico
[Mh] Termos MeSH secundário: Reação de Fase Aguda
Adolescente
Adulto
Anemia Ferropriva/diagnóstico
Proteína C-Reativa/análise
Pré-Escolar
Estudos Transversais
Feminino
Ferritinas/análise
Seres Humanos
Lactente
Inflamação/epidemiologia
Meia-Idade
Estado Nutricional
Obesidade
Orosomucoide/análise
Vitamina A/análise
Deficiência de Vitamina A/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142315


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[PMID]:28615256
[Au] Autor:Rohner F; Namaste SM; Larson LM; Addo OY; Mei Z; Suchdev PS; Williams AM; Sakr Ashour FA; Rawat R; Raiten DJ; Northrop-Clewes CA
[Ad] Endereço:GroundWork, Fläsch, Switzerland; fabian@groundworkhealth.org.
[Ti] Título:Adjusting soluble transferrin receptor concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):372S-382S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Iron deficiency is thought to be one of the most prevalent micronutrient deficiencies globally, but an accurate assessment in populations who are frequently exposed to infections is impeded by the inflammatory response, which causes iron-biomarker alterations. We assessed the relation between soluble transferrin receptor (sTfR) concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and investigated adjustment algorithms to account for these effects. Cross-sectional data from the Biomarkers Reflecting the Inflammation and Nutritional Determinants of Anemia (BRINDA) project from 11,913 PSC in 11 surveys and from 11,173 WRA in 7 surveys were analyzed individually and combined with the use of a meta-analysis. The following 3 adjustment approaches were compared with estimated iron-deficient erythropoiesis (sTfR concentration >8.3 mg/L): ) the exclusion of individuals with C-reactive protein (CRP) concentrations >5 mg/L or α-1-acid glycoprotein (AGP) concentrations >1 g/L, ) the application of arithmetic correction factors, and ) the use of regression approaches. The prevalence of elevated sTfR concentrations incrementally decreased as CRP and AGP deciles decreased for PSC and WRA, but the effect was more pronounced for AGP than for CRP. Depending on the approach used to adjust for inflammation, the estimated prevalence of iron-deficient erythropoiesis decreased by 4.4-14.6 and 0.3-9.5 percentage points in PSC and WRA, respectively, compared with unadjusted values. The correction-factor approach yielded a more modest reduction in the estimated prevalence of iron-deficient erythropoiesis than did the regression approach. Mostly, adjustment for malaria in addition to AGP did not significantly change the estimated prevalence of iron-deficient erythropoiesis. sTfR may be useful to assess iron-deficient erythropoiesis, but inflammation influences its interpretation, and adjustment of sTfR for inflammation and malaria should be considered. More research is warranted to evaluate the proposed approaches in different settings, but this study contributes to the evidence on how and when to adjust sTfR for inflammation and malaria.
[Mh] Termos MeSH primário: Anemia/sangue
Biomarcadores/sangue
Inflamação/sangue
Estado Nutricional
Receptores da Transferrina/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anemia Ferropriva/sangue
Proteína C-Reativa/análise
Pré-Escolar
Estudos Transversais
Eritropoese
Feminino
Seres Humanos
Lactente
Malária/sangue
Meia-Idade
Orosomucoide/análise
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 0 (Receptors, Transferrin); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142232


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[PMID]:28615255
[Au] Autor:Mei Z; Namaste SM; Serdula M; Suchdev PS; Rohner F; Flores-Ayala R; Addo OY; Raiten DJ
[Ad] Endereço:Nutrition Branch, CDC, Atlanta, GA; zam0@cdc.gov.
[Ti] Título:Adjusting total body iron for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):383S-389S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Total body iron (TBI) that is calculated from ferritin and soluble transferrin receptor (sTfR) allows for the evaluation of the full range of iron status from deficiency to excess. However, both ferritin and sTfR are affected by inflammation and malaria, which may require a statistical adjustment. TBI has been used to assess iron status in the United States, but its use worldwide and in settings with inflammation has been limited. We examine whether inflammation-adjusted ferritin and sTfR concentrations affect TBI values and the prevalence of low TBI (<0 mg/kg) in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y). Cross-sectional data for PSC (8 surveys; = 8413) and WRA (4 surveys; = 4258) from the Biomarkers Reflecting the Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and combined. TBI and the prevalence of low TBI were compared following 3 adjustment approaches for ferritin and sTfR: ) the exclusion of individuals with inflammation (C-reactive protein concentration >5 mg/L or α-1-acid glycoprotein concentration >1 g/L), ) the application of arithmetic correction factors, and ) the use of regression correction. Regardless of the method that was used to adjust ferritin and sTfR for inflammation, the adjusted mean TBI decreased in both PSC and WRA compared with unadjusted values. Subsequently, inflammation-adjusted TBI increased the prevalence of low TBI by a median of 4-14 percentage points (pps) in PSC and 1-3 pps in WRA compared with unadjusted TBI. The regression approach resulted in a greater median increase than was achieved with the exclusion or correction-factor approaches, and accounting for malaria in addition to inflammation did not have an added effect on the prevalence estimates. The prevalence of low TBI is underestimated if it is not adjusted by inflammation, particularly in children living in areas with a high prevalence of inflammation.
[Mh] Termos MeSH primário: Anemia
Biomarcadores/análise
Ferro/análise
Ferro/deficiência
Estado Nutricional
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anemia/sangue
Anemia Ferropriva/sangue
Proteína C-Reativa/análise
Pré-Escolar
Estudos Transversais
Reações Falso-Negativas
Feminino
Ferritinas/sangue
Seres Humanos
Lactente
Inflamação
Malária
Meia-Idade
Orosomucoide/análise
Receptores da Transferrina/sangue
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 0 (Receptors, Transferrin); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142307


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[PMID]:28615254
[Au] Autor:Namaste SM; Aaron GJ; Varadhan R; Peerson JM; Suchdev PS; BRINDA Working Group
[Ad] Endereço:Strengthening Partnerships, Results, and Innovations in Nutrition Globally, Arlington, VA; sorrelnamaste@gmail.com.
[Ti] Título:Methodologic approach for the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):333S-347S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project is a multiagency and multicountry collaboration that was formed to improve micronutrient assessment and to better characterize anemia. The aims of the project were to ) identify factors associated with inflammation, ) assess the relations between inflammation, malaria infection, and biomarkers of iron and vitamin A status and compare adjustment approaches, and ) assess risk factors for anemia in preschool children (PSC) and women of reproductive age (WRA). The BRINDA database inclusion criteria included surveys that ) were conducted after 2004, ) had target groups of PSC, WRA, or both, and ) used a similar laboratory methodology for the measurement of ≥1 biomarker of iron [ferritin or soluble transferrin receptor or vitamin A status (retinol-binding protein or retinol)] and ≥1 biomarker of inflammation (α-1-acid glycoprotein or C-reactive protein). Individual data sets were standardized and merged into a BRINDA database comprising 16 nationally and regionally representative surveys from 14 countries. Collectively, the database covered all 6 WHO geographic regions and contained ∼30,000 PSC and 27,000 WRA. Data were analyzed individually and combined with the use of a meta-analysis. The methods that were used to standardize the BRINDA database and the analytic approaches used to address the project's research questions are presented in this article. Three approaches to adjust micronutrient biomarker concentrations in the presence of inflammation and malaria infection are presented, along with an anemia conceptual framework that guided the BRINDA project's anemia analyses. The BRINDA project refines approaches to interpret iron and vitamin A biomarker values in settings of inflammation and malaria infection and suggests the use of a new regression approach as well as proposes an anemia framework to which real-world data can be applied. Findings can inform guidelines and strategies to prevent and control micronutrient deficiencies and anemia globally.
[Mh] Termos MeSH primário: Anemia
Biomarcadores
Inflamação
Micronutrientes/deficiência
Avaliação Nutricional
Estado Nutricional
[Mh] Termos MeSH secundário: Adulto
Anemia/diagnóstico
Anemia Ferropriva/diagnóstico
Biomarcadores/análise
Proteína C-Reativa/análise
Pré-Escolar
Bases de Dados Factuais/normas
Feminino
Ferritinas/análise
Seres Humanos
Inflamação/diagnóstico
Ferro/análise
Malária
Orosomucoide/análise
Proteínas de Ligação ao Retinol/análise
Vitamina A/análise
Deficiência de Vitamina A/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142273


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[PMID]:28615251
[Au] Autor:Larson LM; Namaste SM; Williams AM; Engle-Stone R; Addo OY; Suchdev PS; Wirth JP; Temple V; Serdula M; Northrop-Clewes CA
[Ad] Endereço:Nutrition and Health Sciences Program, Laney Graduate School, and leila.larson@emory.edu.
[Ti] Título:Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):390S-401S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population surveys to measure vitamin A status, but its interpretation is challenging in settings where inflammation is common because RBP concentrations decrease during the acute-phase response. We aimed to assess the relation between RBP concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and to investigate adjustment algorithms to account for these effects. Cross-sectional data from 8 surveys for PSC ( = 8803) and 4 surveys for WRA ( = 4191) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and combined with the use of a meta-analysis. Several approaches were explored to adjust RBP concentrations in PSC in inflammation and malaria settings as follows: ) the exclusion of subjects with C-reactive protein (CRP) concentrations >5 mg/L or α-1-acid glycoprotein (AGP) concentrations >1 g/L, ) the application of arithmetic correction factors, and ) the use of a regression correction approach. The impact of adjustment on the estimated prevalence of VAD (defined as <0.7 µmol/L) was examined in PSC. The relation between estimated VAD and CRP and AGP deciles followed a linear pattern in PSC. In women, the correlations between RBP and CRP and AGP were too weak to justify adjustments for inflammation. Depending on the approach used to adjust for inflammation (CRP+AGP), the estimated prevalence of VAD decreased by a median of 11-18 percentage points in PSC compared with unadjusted values. There was no added effect of adjusting for malaria on the estimated VAD after adjusting for CRP and AGP. The use of regression correction (derived from internal data), which accounts for the severity of inflammation, to estimate the prevalence of VAD in PSC in regions with inflammation and malaria is supported by the analysis of the BRINDA data. These findings contribute to the evidence on adjusting for inflammation when estimating VAD with the use of RBP.
[Mh] Termos MeSH primário: Anemia/sangue
Biomarcadores/sangue
Inflamação/sangue
Estado Nutricional
Proteínas de Ligação ao Retinol/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
Proteína C-Reativa/análise
Pré-Escolar
Estudos Transversais
Reações Falso-Positivas
Feminino
Seres Humanos
Lactente
Malária/sangue
Meia-Idade
Orosomucoide/análise
Valores de Referência
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142166


  10 / 3678 MEDLINE  
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[PMID]:28615252
[Au] Autor:Stoltzfus RJ; Klemm R
[Ad] Endereço:Division of Nutritional Sciences, Cornell University, Ithaca, NY; and rjs62@cornell.edu.
[Ti] Título:Research, policy, and programmatic considerations from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):428S-434S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project sought to inform the interpretation of iron and vitamin A biomarkers (ferritin, serum transferrin receptor, and retinol binding protein) in settings of prevalent inflammation as well as the prevention of and control strategies to address anemia. Our purpose is to comment on the contributions of the BRINDA to advance global knowledge with regard to iron and vitamin A status assessment in women and preschool children and to analyze the findings in terms of their rigor and usefulness for global nutrition research and programs. BRINDA investigators found that the acute-phase response is so prevalent that it must be assessed in surveys of iron and vitamin A status for valid interpretation of micronutrient biomarkers. Furthermore, they found that C-reactive protein and α-1-acid glycoprotein provide important and different information about these responses and that common survey variables cannot replace the information they provide. Developing a method for adjusting micronutrient biomarkers for the independent influence of inflammation is challenging and complex, and BRINDA has brought greater clarity to this challenge through the use of large and diverse data sets. When comparing approaches, the regression methods appear to perform best when sample sizes are sufficient and adequate statistical capacity is available. Further correction for malaria does not appear to materially alter regression-adjusted prevalence estimates. We suggest that researchers present both adjusted and unadjusted values for the micronutrient biomarkers. BRINDA findings confirm that iron deficiency is a common and consistent risk factor for anemia globally and that anemia control must combine iron interventions with control of infection and inflammation. Anemia control strategies must be informed by local data. By applying the knowledge in these studies, researchers, program planners, and evaluators working in populations with prevalent inflammation can use and interpret biomarkers with more confidence, tempered with necessary caution.
[Mh] Termos MeSH primário: Anemia
Biomarcadores/análise
Pesquisa Biomédica
Política de Saúde
Inflamação
Estado Nutricional
[Mh] Termos MeSH secundário: Anemia Ferropriva
Proteína C-Reativa
Pré-Escolar
Feminino
Ferritinas/sangue
Seres Humanos
Lactente
Ferro/deficiência
Micronutrientes/deficiência
Orosomucoide/análise
Receptores da Transferrina/sangue
Proteínas de Ligação ao Retinol/análise
Fatores de Risco
Deficiência de Vitamina A
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Receptors, Transferrin); 0 (Retinol-Binding Proteins); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142372



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