|
[PMID]: | 28755727 |
[Au] Autor: | Yao K; Zhang L; Zhou H; Tang N; Li D |
[Ad] Endereço: | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. |
[Ti] Título: | Plasma Antiphospholipid Antibodies Effects on Activated Partial Thromboplastin Time Assays. |
[So] Source: | Am J Med Sci;354(1):22-26, 2017 Jul. | [Is] ISSN: | 1538-2990 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: Activated partial thromboplastin time (aPTT) assays can be affected by plasma antiphospholipid antibodies (aPLs), but the degree of the interference is not easy to predict. This study aimed to investigate the effects on aPTT assay results of different types and combinations of aPLs, including anti-ß -glycoprotein I antibodies, anticardiolipin antibodies and lupus anticoagulant. MATERIALS AND METHODS: We retrospectively collected clinical information and laboratory tests from aPL-positive patients. The potential influence of aPLs on aPTT assays was assessed. RESULTS: The survey included 589 aPL-positive patients. No significant differences existed in basic characteristics such as sex, age, prothrombin time, fibrinogen and alanine aminotransferase among different cases with 1, 2 or 3 types of positive-aPL markers (P > 0.05). In 113 patients with abnormal aPTT values, multivariable linear regression analysis showed a significant correlation between an abnormal degree of aPTT values and dilute Russell viper venom time (dRVVT) or silica clotting time (SCT) with a correlation coefficient of 0.437 or 0.497 (P < 0.01), whereas age, anticardiolipin antibodies-immunoglobulin G, anticardiolipin antibodies-immunoglobulin M and anti-ß -glycoprotein I antibodies were of no significance (P > 0.05). Among blood samples with 3 types of aPLs positivity, the rate of abnormal aPTT detection values was 55.3%, which was significantly higher than that observed in patients with negative, single-positive or double-positive aPL markers (P < 0.05). Patients with a moderate to strong dRVVT or SCT had a higher proportion of abnormal aPTT assays than did patients with a low dRVVT or SCT (P < 0.05). CONCLUSIONS: When abnormal aPTT values are obtained, the influence of aPLs should be considered, especially in the presence of a moderate to strong dRVVT or SCT. |
[Mh] Termos MeSH primário: |
Anticorpos Antifosfolipídeos/metabolismo Tempo de Tromboplastina Parcial beta 2-Glicoproteína I/metabolismo
|
[Mh] Termos MeSH secundário: |
Adulto Anticorpos Anticardiolipina/metabolismo Feminino Seres Humanos Inibidor de Coagulação do Lúpus/metabolismo Masculino Meia-Idade Estudos Retrospectivos
|
[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Antibodies, Anticardiolipin); 0 (Antibodies, Antiphospholipid); 0 (Lupus Coagulation Inhibitor); 0 (beta 2-Glycoprotein I) |
[Em] Mês de entrada: | 1708 |
[Cu] Atualização por classe: | 170824 |
[Lr] Data última revisão:
| 170824 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 170731 |
[St] Status: | MEDLINE |
|
|
|