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[PMID]: 29484750 [Au] Autor: Saraswati S; Alhaider AA; Abdelgadir AM [Ad] Endereço: Camel Biomedical Research Unit, College of Pharmacy and Medicine, King Saud University, Riyadh, Saudi Arabia. [Ti] Título: Costunolide suppresses an inflammatory angiogenic response in a subcutaneous murine sponge model. [So] Source: APMIS;126(3):257-266, 2018 Mar. [Is] ISSN: 1600-0463 [Cp] País de publicação: Denmark [La] Idioma: eng [Ab] Resumo: Costunolide is known to possess anti-inflammatory and antitumor activity, but its role in tumor angiogenesis, the key step involved in tumor growth and metastasis, and the involved molecular mechanism is still unknown. We aimed to investigate the effects of costunolide on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and costunolide (5, 10 and 20 mg/kg/day) was administered for 14 days through installed cannula. The implants collected at day 14 post-implantation were processed for the assessment of hemoglobin (Hb), myeloperoxidase (MPO), N-acetylglucosaminidase (NAG) and collagen, which were used as indices for angiogenesis, neutrophil and macrophage accumulation, and extracellular matrix deposition, respectively. Relevant inflammatory, angiogenic and fibrogenic cytokines were also determined. Costunolide treatment attenuated the main components of the fibrovascular tissue, wet weight, vascularization (Hb content), macrophage recruitment (NAG activity), collagen deposition, and the levels of vascular endothelial growth factor (VEGF), interleukin (IL)-1ß, IL-6, IL-17, tumor necrosis factor (TNF)-α and transforming growth factor (TGF-ß). Regulatory function of costunolide on multiple parameters of the main components of inflammatory angiogenesis has been revealed giving insight into the potential therapeutic benefit underlying the anti-angiogenic actions of costunolide. [Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia Macrófagos/imunologia Neovascularização Patológica/imunologia Neutrófilos/imunologia Poliésteres/efeitos adversos Poliuretanos/efeitos adversos Sesquiterpenos/farmacologia [Mh] Termos MeSH secundário: Acetilglucosaminidase/metabolismo Animais Colágeno/metabolismo Citocinas/metabolismo Modelos Animais de Doenças Hemoglobinas/metabolismo Masculino Camundongos Peroxidase/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Angiogenesis Inhibitors); 0 (Cytokines); 0 (Hemoglobins); 0 (Polyesters); 0 (Polyurethanes); 0 (Sesquiterpenes); 4IK578SA7Z (costunolide); 9007-34-5 (Collagen); EC 1.11.1.7 (Peroxidase); EC 3.2.1.52 (Acetylglucosaminidase) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180228 [St] Status: MEDLINE [do] DOI: 10.1111/apm.12808

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[PMID]: 29385208 [Au] Autor: Mupfumi L; Moyo S; Molebatsi K; Thami PK; Anderson M; Mogashoa T; Iketleng T; Makhema J; Marlink R; Kasvosve I; Essex M; Musonda RM; Gaseitsiwe S [Ad] Endereço: Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana. [Ti] Título: Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana. [So] Source: PLoS One;13(1):e0192030, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: There is a high burden of tuberculosis (TB) in HIV antiretroviral programmes in Africa. However, few studies have looked at predictors of incident TB while on Truvada-based combination antiretroviral therapy (cART) regimens. METHODS: We estimated TB incidence among individuals enrolled into an observational cohort evaluating the efficacy and tolerability of Truvada-based cART in Gaborone, Botswana between 2008 and 2011. We used Cox proportional hazards regressions to determine predictors of incident TB. RESULTS: Of 300 participants enrolled, 45 (15%) had a diagnosis of TB at baseline. During 428 person-years (py) of follow-up, the incidence rate of TB was 3.04/100py (95% CI, 1.69-5.06), with 60% of the cases occurring within 3 months of ART initiation. Incident cases had low baseline CD4+ T cell counts (153cells/mm3 [Q1, Q3: 82, 242]; p = 0.69) and hemoglobin levels (9.2g/dl [Q1, Q3: 8.5,10.1]; p<0.01). In univariate analysis, low BMI (HR = 0.73; 95% CI 0.58-0.91; p = 0.01) and hemoglobin levels <8 g/dl (HR = 10.84; 95%CI: 2.99-40.06; p<0.01) were risk factors for TB. Time to incident TB diagnosis was significantly reduced in patients with poor immunological recovery (p = 0.04). There was no association between baseline viral load and risk of TB (HR = 1.75; 95%CI: 0.70-4.37). CONCLUSION: Low hemoglobin levels prior to initiation of ART are significant predictors of incident tuberculosis. Therefore, there is potential utility of iron biomarkers to identify patients at risk of TB prior to initiation on ART. Furthermore, additional strategies are required for patients with poor immunological recovery to reduce excess risk of TB while on ART. [Mh] Termos MeSH primário: Infecções por HIV/complicações Hemoglobinas/metabolismo Tuberculose/complicações [Mh] Termos MeSH secundário: Adulto Botsuana Contagem de Linfócito CD4 Feminino Infecções por HIV/sangue Infecções por HIV/imunologia Seres Humanos Masculino Estudos Retrospectivos Fatores de Risco Tuberculose/sangue Tuberculose/diagnóstico Tuberculose/imunologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hemoglobins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0192030

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[PMID]: 29205002 [Au] Autor: Ding DX; Ding M [Ad] Endereço: Department of Forensic Serology, Faculty of Forensic Medicine, China Medical University, Shenyang 110001, China. [Ti] Título: [Application of Multiple Displacement Amplification in Samples with Inhibitors]. [So] Source: Fa Yi Xue Za Zhi;32(5):342-345, 2016 Oct. [Is] ISSN: 1004-5619 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: OBJECTIVES: To explore the ability of inhibition resistibility of multiple displacement amplification （MDA） in samples with inhibitors. To explain the application and value of MDA in forensic medicine by comparing with using magnetic beads methods （MBM） to purify sample. METHODS: Different concentrations of hemoglobin and humid acid （HA） mixed with DNA samples and then divided the samples into MDA group, MBM group and control group. locus was amplified and detected by polyacrylamide gel electrophoresis detection system and AmpFâ„“STR® Identifiler™ Plus Kit-capillary electrophoresis detection system. RESULTS: When hemoglobin concentrations exceed 1 ng/µL or HA concentrations exceed 0.1 ng/µL, amplification products could not be obtained by single-locus system in control group. When hemoglobin concentration exceeds 100 ng/µL or HA concentrations exceed 1 ng/µL, the samples could not be amplified by MBM. Inhibitors in different concentrations were amplified successfully in MDA group without any influence from inhibitors. CONCLUSIONS: MDA has the capability to remove the inhibition of hemoglobin and HA, which is better than MBM and has a certain value in forensic practices. [Mh] Termos MeSH primário: DNA/análise Medicina Legal/métodos Técnicas de Amplificação de Ácido Nucleico [Mh] Termos MeSH secundário: Eletroforese em Gel de Poliacrilamida Hemoglobinas Seres Humanos Substâncias Húmicas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hemoglobins); 0 (Humic Substances); 9007-49-2 (DNA) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171206 [St] Status: MEDLINE [do] DOI: 10.3969/j.issn.1004-5619.2016.05.006

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[PMID]: 28470926 [Au] Autor: Lehle K; Lubnow M; Philipp A; Foltan M; Zeman F; Zausig Y; Lunz D; Schmid C; Müller T [Ad] Endereço: Department of Cardiothoracic Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany. [Ti] Título: Prevalence of hemolysis and metabolic acidosis in patients with circulatory failure supported with extracorporeal life support: a marker for survival? [So] Source: Eur J Heart Fail;19 Suppl 2:110-116, 2017 May. [Is] ISSN: 1879-0844 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: AIMS: Elevated levels of plasma free hemoglobin (fHb) indicate red blood cell (RBC) damage. The aim of this study was to analyze the prevalence of hemolysis and metabolic acidosis in patients on extracorporeal life support (ECLS) and to investigate whether it is a marker for outcome. METHODS AND RESULTS: This retrospective analysis included 215 adult patients with cardiac failure treated with ECLS. The cohort was divided into three groups: ECLS (1) during ongoing cardiopulmonary resuscitation (CPR, n = 110); (2) after CPR with return of spontaneous circulation and sustained cardiogenic shock (n = 45); (3) in severe cardiogenic shock without previous CPR (n = 60). Lactate, arterial pH value and fHb were measured daily before (pre-fHb) and during ECLS. CPR caused a pronounced increase in pre-fHb (group1, 318 (138/586) mg/L; group2, 212 (107/439) mg/L; group3, 79 (53/232) mg/L; p < 0.001). Within 24 hours on ECLS, fHb declined significantly. Compared to group 3 without CPR, group1 and 2 had a lower pH value (group1, 7.10 (6.93/7.20); group2, 7.21 (7.16/7.27); group3, 7.28 (7.20/7.35); p < 0.001), and an increased lactate level (group1, 88 (55/129) mg/dL; group2, 76 (36/111) mg/dL; group3, 52 (25/83) mg/dL; p < 0.0001). Multivariante analysis showed that pre-fHb had no prognostic value for survival. Only a low pre-lactate was a surrogate marker for successful weaning (p < 0.0001) and discharge from hospital (p = 0.0028). CONCLUSIONS: CPR was associated with a strongly increased fHb irrespective of ECLS. Implantation of ECLS did not aggravate hemolysis but instead decreased it within 24 hours. In this study low pre-fHb had no predictive value for survival. [Mh] Termos MeSH primário: Acidose/epidemiologia Anemia Hemolítica/epidemiologia Oxigenação por Membrana Extracorpórea/efeitos adversos Insuficiência Cardíaca/terapia Hemólise [Mh] Termos MeSH secundário: Acidose/sangue Acidose/etiologia Idoso Anemia Hemolítica/sangue Anemia Hemolítica/etiologia Feminino Alemanha/epidemiologia Hemoglobinas/metabolismo Seres Humanos Masculino Meia-Idade Prevalência Prognóstico Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hemoglobins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1002/ejhf.854

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[PMID]: 28452395 [Au] Autor: Stangerup I; Kramp NL; Ziegler AK; Dela F; Magnussen K; Helge JW [Ad] Endereço: Centre of Healthy Aging, Xlab, Department of Biomedical Sciences, University of Copenhagen, Copenhagen. [Ti] Título: Temporary impact of blood donation on physical performance and hematologic variables in women. [So] Source: Transfusion;57(8):1905-1911, 2017 08. [Is] ISSN: 1537-2995 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: No former studies have examined how blood donation influences physical performance in women, who due to menstruation may have a slower recovery of performance. Therefore, the aim of this study was to clarify how VO , time trial (TT) performance, and hematologic variables are affected in 18 iron-sufficient (plasma ferritin [P-ferritin] > 30 µg/L) women after a standard 450-mL blood donation. STUDY DESIGN AND METHODS: VO , TT performance, and blood variables were measured at baseline and 3, 7, 14, 21, and 28 days after blood donation in 18 iron-sufficient women. Anthropometrics were measured at baseline and Day 28. RESULTS: VO was reduced by 7.5 ± 1.1% from 2973 ± 87 mL/min at baseline to 2765 ± 73 mL/min 3 days after blood donation and remained below baseline until 28 days. The TT performance was reduced by 5.2 ± 1.0% from baseline (868 ± 31 sec) to Day 3 (915 ± 29 sec), but was not different from baseline 14 days after blood donation. Blood hemoglobin (B-Hb) concentration declined by 7.6 ± 2.1% from 8.4 ± 0.1 to 7.8 ± 0.1 mmol/L at baseline and on Day 3, respectively. P-ferritin at baseline was 58 ± 7 µg/L and it decreased (55 ± 3%) to a nadir of 24 ± 3 µg/L 28 days after blood donation and remained lower at 36 ± 4 µg/L after 90 days. CONCLUSION: VO and B-Hb were only recovered 28 days after a blood donation whereas TT performance was back to baseline 14 days after blood donation. [Mh] Termos MeSH primário: Doadores de Sangue Ferritinas/sangue Hemoglobinas/análise Resistência Física/fisiologia [Mh] Termos MeSH secundário: Adulto Teste de Esforço Feminino Seres Humanos Recuperação de Função Fisiológica Testes de Função Respiratória Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hemoglobins); 9007-73-2 (Ferritins) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1111/trf.14121

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[PMID]: 28450652 [Au] Autor: Wirawan R; Tedja AT; Henrika F; Lydia A [Ad] Endereço: Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. riadiwirawan@yahoo.com. [Ti] Título: Concordance between Reticulocyte Hemoglobin Equivalent and Reticulocyte Hemoglobin Content in CKD Patients Undergoing Hemodialysis. [So] Source: Acta Med Indones;49(1):34-40, 2017 Jan. [Is] ISSN: 0125-9326 [Cp] País de publicação: Indonesia [La] Idioma: eng [Ab] Resumo: AIM: to evaluate the correlation and the concordance between reticulocyte hemoglobin equivalent (RET-He) and reticulocyte hemoglobin content (CHr) as well as to obtain the cut-off value of RET-He as the target of iron supplementation in chronic kidney disease (CKD) patients undergoing hemodialysis. METHODS: a cross-sectional study was performed using K3EDTA-anticoagulated peripheral blood samples collected from 106 CKD patients undergoing routine hemodialysis. The samples were then analyzed using both Sysmex XN-2000 and Siemens ADVIA 2120i for RET-He and CHr analysis. RESULTS: a very strong correlation (r=0.91; p<0.0001) and a good concordance were found between RET-He and CHr with mean bias of 0.5 pg. The diagnostic concordance was 96.23%. The cut-off value of RET-He 29.2 pg was obtained from the receiver operating characteristic (ROC) curve with CHr as the gold standard. At this cut-off point, the sensitivity and specificity to assess the target of iron supplementation in CKD patients undergoing hemodialysis were 95.5% and 94%, respectively. CONCLUSION: the study shows a good correlation and concordance between RET-He and CHr in CKD patients undergoing hemodialysis. [Mh] Termos MeSH primário: Anemia Ferropriva/sangue Hemoglobinas/análise Insuficiência Renal Crônica/sangue Insuficiência Renal Crônica/complicações Reticulócitos/química [Mh] Termos MeSH secundário: Adulto Anemia Ferropriva/etiologia Estudos Transversais Feminino Seres Humanos Indonésia Masculino Meia-Idade Curva ROC Valores de Referência Diálise Renal Insuficiência Renal Crônica/terapia Sensibilidade e Especificidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hemoglobins) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 29206824 [Au] Autor: Sedano-Portillo I; Ochoa-León G; Fuentes-Orozco C; Irusteta-Jiménez L; Michel-Espinoza LR; Salazar-Parra M; Cuesta-Márquez L; González-Ojeda A [Ad] Endereço: Departamento de Urología, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jal., México. [Ti] Título: [Approach to percutaneous nephrolithotomy. Comparison of the procedure in a one-shot versus the sequential with metal dilata]. [Ti] Título: Abordaje para nefrolitotomía percutánea. Comparación del procedimiento en un solo paso contra la secuencial con dilatadores metálicos.. [So] Source: Gac Med Mex;153(6):677-682, 2017 Nov-Dec. [Is] ISSN: 0016-3813 [Cp] País de publicação: Mexico [La] Idioma: spa [Ab] Resumo: INTRODUCTION: Percutaneous nephrolithotomy is an efficient approach for treatment of different types of kidney stones. Various types of access techniques have been described like sequential dilatation and one-shot procedure. OBJECTIVE: To determine the differences in time of exposure to X-rays and hemoglobin levels between techniques. METHODS: Controlled clinical trial. Patients older than 18 years with complex/uncomplicated kidney stones, without urine infection were included. They were assigned randomly to one of the two techniques. Response variables were determined before and 24 h after procedures. RESULTS: 59 patients were included: 30 underwent one-shot procedure (study-group) and 29 sequential dilatation (control-group). Baseline characteristics were similar. Study group had a lower postoperative hemoglobin decline than control group (0.81 vs. 2.03 g/dl, respectively; p < 0.001); X-ray exposure time (69.6 vs. 100.62 s; p < 0.001) and postoperative creatinine serum levels (0.93 ± 0.29 vs. 1.13 ± 0.4 mg/dl; p = 0.039). No significant differences in postoperative morbidity were found. CONCLUSION: One-shot technique demonstrated better results compared to sequential dilatation. [Mh] Termos MeSH primário: Dilatação/métodos Cálculos Renais/cirurgia Nefrolitotomia Percutânea/métodos Complicações Pós-Operatórias/epidemiologia [Mh] Termos MeSH secundário: Adulto Creatinina/sangue Feminino Hemoglobinas/metabolismo Seres Humanos Masculino Metais Meia-Idade Resultado do Tratamento [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Hemoglobins); 0 (Metals); AYI8EX34EU (Creatinine) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171206 [St] Status: MEDLINE [do] DOI: 10.24875/GMM.17002655

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[PMID]: 27773451 [Au] Autor: Gavalas MV; Breskin A; Yuzefpolskaya M; Eisenberger A; Castagna F; Demmer RT; Flannery M; Garan AR; Takeda K; Takayama H; Naka Y; Topkara VK; Colombo PC [Ad] Endereço: Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, New York. [Ti] Título: Discriminatory performance of positive urine hemoglobin for detection of significant hemolysis in patients with continuous-flow left ventricular assist devices. [So] Source: J Heart Lung Transplant;36(1):59-63, 2017 Jan. [Is] ISSN: 1557-3117 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Serum lactate dehydrogenase (LDH) is the standard measure for detection of hemolysis and thus surveillance for device thrombosis in patients on continuous-flow left ventricular assist device (CF-LVAD) support. Significant hemolysis has been defined as LDH ≥600 IU/L. However, LDH testing requires phlebotomy, precluding frequent home monitoring. Simple dipstick urinalysis (UA) for urine hemoglobin (U-Hb) overcomes this limitation. This study correlated U-Hb and LDH levels and evaluated the performance of UA for detection of significant hemolysis in patients with CF-LVADs. METHODS: U-Hb and LDH were measured concurrently 956 times in 221 patients with CF-LVADs. Statistics were computed to determine accuracy of UA in detecting LDH ≥600 IU/L, with a positive result being any detected U-Hb. All analyses were performed with and without excluding for 1) conditions associated with tissue damage, which are known to increase LDH, and 2) suspected or confirmed urinary tract infections or hematuria, which are known to cause hemoglobinuria for reasons other than hemolysis. RESULTS: Mean LDH for absent/mild/severe U-Hb was 360 IU/L/467 IU/L IU/L/777 IU/L without exclusions, 354 IU/L/444 IU/L IU/L/651 IU/L after excluding non-hemolytic LDH elevations, 370 IU/L/513 IU/L IU/L/1,357 IU/L after excluding urinary tract infections and hematuria, and 367 IU/L/470 IU/L IU/L/1,217 IU/L when both exclusions applied (all p < 0.001). Absent U-Hb had a negative predictive value for LDH ≥600 IU/L of >90% for all analyses. CONCLUSIONS: Serum LDH is significantly associated with U-Hb levels. Absence of U-Hb appears to efficiently exclude significant hemolysis in patients with CF-LVADs. Because it can be performed by patients at home, hemoglobinuria monitoring may enable more intense surveillance and earlier diagnosis of device thrombosis. [Mh] Termos MeSH primário: Insuficiência Cardíaca/terapia Coração Auxiliar/efeitos adversos Hemoglobinas/metabolismo Hemólise/fisiologia Trombose/urina [Mh] Termos MeSH secundário: Biomarcadores/sangue Biomarcadores/urina Falha de Equipamento Feminino Insuficiência Cardíaca/mortalidade Insuficiência Cardíaca/urina Seres Humanos Incidência Estimativa de Kaplan-Meier L-Lactato Desidrogenase/sangue Masculino Meia-Idade New York/epidemiologia Reprodutibilidade dos Testes Estudos Retrospectivos Fatores de Risco Taxa de Sobrevida/tendências Trombose/diagnóstico Trombose/etiologia Urinálise Urofolitropina [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Hemoglobins); 0 (Urofollitropin); EC 1.1.1.27 (L-Lactate Dehydrogenase) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 29390387 [Au] Autor: Zhang X; He Y; Xie X; Ji M; Ma X; Yu Z [Ad] Endereço: Public Health College of Zhengzhou University, Zhengzhou. [Ti] Título: Distribution of hemoglobin and prevalence of anemia in 10 ethnic minorities in China: A population-based, cross-sectional study. [So] Source: Medicine (Baltimore);96(50):e9286, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Racial differences have been reported in hemoglobin (Hb). However, distributions of Hb and anemia rate in ethnic minorities were rarely reported.We aimed to observe whether there are ethnic differences in Hb distributions and prevalence of anemia.The data included 480,699 women 20 to 49 years' old from 10 ethnic minorities in China in 2014. Analyses of variance were used to examine the differences of Hb distribution among the 10 ethnic groups, as well as the differences in Hb level between different ages, education levels, occupations, and non- or ethnic enclaves in each ethnic group. χ2-test was adopted to analyze the differences in anemia rate among the 10 ethnic groups and between different ages and nonethnic or ethnic enclaves in each ethnic group.The ethnic differences of the Hb distribution and anemia prevalence were observed in the 10 ethnic groups. The lowest mean Hb concentration was shown in Chuang (126.8 g/L), and the highest mean Hb concentration was in Tibetan (138.5 g/L). According to the World Health Organization criteria to define anemia, the highest prevalence was in Tibetan (46.9%) after the adjustment of Hb concentration for altitude, and the lowest prevalence was in Yi (10.6%). Furthermore, there were differences on mean Hb concentration or anemia rate in participants between ethnic enclaves and non-ethnic enclaves in most ethnic groups.The ethnic differences of the Hb distribution and anemia prevalence were observed in the 10 ethnic groups, which might be associated with geographic conditions, genetic background, and eating habits. [Mh] Termos MeSH primário: Anemia/etnologia Anemia/epidemiologia Hemoglobinas/análise [Mh] Termos MeSH secundário: Adulto China/epidemiologia Estudos Transversais Feminino Seres Humanos Masculino Meia-Idade Prevalência [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hemoglobins) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009286

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[PMID]: 29260810 [Au] Autor: Chang S; Mizuno M; Ishikawa H; Mizutani Y [Ad] Endereço: Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. mztn@chem.sci.osaka-u.ac.jp. [Ti] Título: Tertiary dynamics of human adult hemoglobin fixed in R and T quaternary structures. [So] Source: Phys Chem Chem Phys;20(5):3363-3372, 2018 Jan 31. [Is] ISSN: 1463-9084 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Protein dynamics of human adult hemoglobin and its mutants restricted in R and T quaternary states following ligand photolysis were studied by time-resolved resonance Raman spectroscopy. In the time-resolved spectra, we observed spectral changes of in-plane stretching modes of heme and the iron-histidine stretching mode of the Fe-His bond for all the hemoglobin samples. The ßD99N mutant, which adopts the R state in both the ligand-bound and the deoxy forms, showed similar temporal behaviors in time-resolved resonance Raman spectra as wild-type recombinant hemoglobin until 10 µs, consistent with the fact that the mutant undergoes only the tertiary structural changes in the R state. The ßN102T mutant, which adopts the T state in both the ligand-bound and the deoxy forms, showed much slower tertiary structural changes, suggesting that the EF helical motion is decelerated by the change of the intersubunit interactions. The present data indicate that the allosteric kinetic response between the interhelical hydrogen bonds of the EF helices and the intersubunit hydrogen bonds is bidirectional. The implications of these results for understanding the allosteric pathway of Hb are discussed in detail. [Mh] Termos MeSH primário: Hemoglobinas/química [Mh] Termos MeSH secundário: Adulto Heme/química Heme/metabolismo Hemoglobinas/genética Hemoglobinas/metabolismo Histidina/química Histidina/metabolismo Seres Humanos Ligações de Hidrogênio Mutagênese Sítio-Dirigida Estrutura Quaternária de Proteína Proteínas Recombinantes/biossíntese Proteínas Recombinantes/química Proteínas Recombinantes/isolamento & purificação Análise Espectral Raman [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hemoglobins); 0 (Recombinant Proteins); 42VZT0U6YR (Heme); 4QD397987E (Histidine) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE [do] DOI: 10.1039/c7cp06287g

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