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[PMID]:28801997
[Au] Autor:Nakavachara P; Petchkul J; Jeerawongpanich K; Kiattisakthavee P; Manpayak T; Netsakulnee P; Chaichanwattanakul K; Pooliam J; Srichairatanakool S; Viprakasit V
[Ad] Endereço:Division of Pediatric Endocrinology, Faculty of Medicine Siriraj Hospital, Department of Pediatrics, Mahidol University, Bangkok, Thailand.
[Ti] Título:Prevalence of low bone mass among adolescents with nontransfusion-dependent hemoglobin E/ß-thalassemia and its relationship with anemia severity.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Low bone mass is common among adolescents with transfusion-dependent ß-thalassemia despite adequate transfusion and iron chelation. However, there are few reports regarding bone mineral density (BMD) among adolescents with nontransfusion-dependent thalassemia (NTDT). Indeed, only BMD data in patients with nontransfusion-dependent (NTD) ß-thalassemia intermedia have been reported. No previous study has investigated BMD among adolescents with NTD hemoglobin (Hb) E/ß-thalassemia. OBJECTIVE: To determine the prevalence of low bone mass among adolescents with NTD Hb E/ß-thalassemia and factors relating to low bone mass. METHODS: We investigated BMD of lumbar spine (L2-L4; BMDLS) and total body (BMDTB), as measured by dual-energy X-ray absorptiometry, in 22 adolescents (aged 13.2-20 years) with NTD Hb E/ß-thalassemia. RESULTS: Low bone mass was found to be 18.2% and 22.7% at the lumbar spine (BMDLS Z-score adjusted for bone age and height age) and 13.6% and 9.1% at the total body (BMDTB Z-score adjusted for bone age and height age). Patients with mean Hb level <8 g/dl were more likely to have low bone mass (BMDLS and BMDTB Z-scores adjusted for bone age) compared to those with Hb level ≥ 8 g/dl. Mean Hb level correlated with BMDLS and BMDTB Z-scores adjusted for bone age. CONCLUSION: We demonstrated that a low Hb level was associated with low bone mass among adolescents with NTD Hb E/ß-thalassemia. A significant proportion of low bone mass among these patients highlights the importance of appropriate management, including red cell transfusion, vitamin D and calcium supplementation for improved long-term bone health.
[Mh] Termos MeSH primário: Absorciometria de Fóton
Densidade Óssea
Vértebras Lombares
Talassemia beta
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Hemoglobina E
Seres Humanos
Vértebras Lombares/diagnóstico por imagem
Vértebras Lombares/metabolismo
Vértebras Lombares/fisiopatologia
Masculino
Índice de Gravidade de Doença
Talassemia beta/diagnóstico por imagem
Talassemia beta/metabolismo
Talassemia beta/fisiopatologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
9034-61-1 (Hemoglobin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26744


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[PMID]:28848193
[Au] Autor:Deeruksa L; Sanchaisuriya K
[Ad] Endereço:Public Health Program, Faculty of Science, Udon Thani Rajabhat University, Udon Thani, Thailand.
[Ti] Título:Anemia in the Elderly in Northeastern Thailand: A Community-Based Study Investigating Prevalence, Contributing Factors, and Hematologic Features.
[So] Source:Acta Haematol;138(2):96-102, 2017.
[Is] ISSN:1421-9662
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This community-based study investigated anemia prevalence and certain hematologic features and their possible relationships to thalassemia and iron deficiency (ID) in a population of older people in Northeastern Thailand. Participants included 319 apparently healthy individuals ranging in age from 60 to 98 years, whose current health status was assessed by means of personal interviews. Blood samples were also collected to determine the following parameters: red blood cell indices, serum ferritin, C-reactive protein, hemoglobin profiles, and the α0-thalassemia gene. Based upon established WHO criteria, the overall prevalence of anemia was found to be 47.7%, increasing from 39% within the age group of 60-70 years to 68% in those >80 years. Factors considered to be significant contributors to anemia were classified as ID (3.6%), thalassemia (56.2%), and "unknown" (40.1%). Overall, only 2.4% of participants exhibited any ID. Hematologic changes appear to correlate with age. Our findings provide not only baseline information, potentially useful for implementing appropriate control measures, but also an enhanced awareness and understanding of the factors contributing to anemia among the elderly in the region.
[Mh] Termos MeSH primário: Anemia Ferropriva/epidemiologia
Talassemia/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Proteína C-Reativa/análise
Feminino
Hemoglobina E/análise
Hemoglobinas/análise
Seres Humanos
Imunoensaio
Masculino
Meia-Idade
Prevalência
Tailândia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); 9007-41-4 (C-Reactive Protein); 9034-61-1 (Hemoglobin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1159/000478771


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[PMID]:28531196
[Au] Autor:Deng Z; Yang F; Bai Y; He L; Li Q; Wu Y; Luo L; Li H; Ma L; Yang Z; He Y; Cui L
[Ad] Endereço:Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.
[Ti] Título:Co-inheritance of glucose-6-phosphate dehydrogenase deficiency mutations and hemoglobin E in a Kachin population in a malaria-endemic region of Southeast Asia.
[So] Source:PLoS One;12(5):e0177917, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobin E (HbE, ß26 Glu-Lys) are two common red cell disorders in Southeast Asia. G6PD deficiency produces hemolytic anemia, which can be triggered by certain drugs or infections. HbE is asymptomatic or is manifested as microcytic, minimally hemolytic anemia. The association between G6PD deficiency and HbE is little understood. This study aimed to investigate G6PD deficiency and HbE in a Kachin ethnic group in the China-Myanmar border area. G6PD enzyme activity was measured using a quantitative G6PD assay, G6PD variants genotyped by the SNaPshot assay, and an HbE gene mutation identified by an amplification refractory mutation system and subsequently confirmed by using a reverse dot blot hybridization assay from 100 unrelated individuals in the study area. G6PD enzyme activity ranged from 0.4 to 24.7 U/g Hb, and six males had severe G6PD deficiency (<0.12-1.2 U/g Hb), while six males and 12 females had mild G6PD deficiency (>1.2-4.5 U/g Hb). Among the 24 G6PD-deficient subjects, 22 (92%) had the Mahidol 487G>A mutation (12 male hemizygotes, one female homozygote, and nine female heterozygotes), while the G6PD genotypes in two female subjects were unknown. HbE was identified in 39 subjects (20 males and 19 females), including 15 HbEE (seven males and eight females) and 24 HbAE (13 males and 11 females). Twenty-three subjects co-inherited both G6PD deficiency and HbE (22 with HbAE and one with HbEE). Whereas mean Hb levels were not significantly different between the HbA and HbE groups, G6PD-deficient males had significantly lower Hb levels than G6PD-normal males (P < 0.05, t-test). However, it is noteworthy that two G6PD-deficient hemizygous males with HbAE were severely anemic with Hb levels below 50 g/L. This study revealed high prevalence of co-inheritance of G6PD deficiency with HbAE in the Kachin ethnicity, and a potential interaction of the G6PD Mahidol 487G>A and HbAE in males leading to severe anemia. The presence of 6% males with severe G6PD deficiency raised a major concern in the use of primaquine for radical cure of vivax malaria.
[Mh] Termos MeSH primário: Deficiência de Glucosefosfato Desidrogenase/epidemiologia
Glucosefosfato Desidrogenase/genética
Hemoglobina E/genética
Hemoglobinúria/epidemiologia
Malária/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
China/epidemiologia
China/etnologia
Comorbidade
Doenças Endêmicas
Feminino
Genótipo
Glucosefosfato Desidrogenase/metabolismo
Deficiência de Glucosefosfato Desidrogenase/etnologia
Hemoglobinúria/etnologia
Seres Humanos
Malária/etnologia
Masculino
Meia-Idade
Mutação
Mianmar/epidemiologia
Mianmar/etnologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9034-61-1 (Hemoglobin E); EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177917


  4 / 844 MEDLINE  
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[PMID]:28497611
[Au] Autor:Singha K; Srivorakun H; Fucharoen G; Fucharoen S
[Ad] Endereço:Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
[Ti] Título:Co-inheritance of α -thalassemia elevates Hb A level in homozygous Hb E: Diagnostic implications.
[So] Source:Int J Lab Hematol;39(5):508-512, 2017 Oct.
[Is] ISSN:1751-553X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Differentiation of homozygous hemoglobin (Hb) E with and without α -thalassemia is subtle on routine hematological ground. We examined in a large cohort of homozygous Hb E if the level of Hb A is helpful. METHODS: A total of 592 subjects with homozygous Hb E were recruited from ongoing thalassemia screening program. Additionally, five couples at risk of having fetuses with Hb Bart's hydrops fetalis who were homozygous Hb E were also investigated. Hb analysis was performed using capillary electrophoresis system. Globin genotypes were defined by DNA analysis. RESULTS: Subjects were classified into four groups including pure homozygous Hb E (n=532), homozygous Hb E/α -thalassemia (n=48), Hb Constant Spring EE Bart's disease (n=8), and Hb EE Bart's disease (n=4). The levels of Hb A were found, respectively, to be 4.97±0.69, 6.64±1.02, 4.86±0.87, and 7.60±1.04%. Among five couples at risk, α -thalassemia was identified in three subjects with Hb A >6.0%. CONCLUSIONS: Increased Hb A level is a useful marker for differentiation of homozygous Hb E with and without α -thalassemia. This should lead to a significant reduction in number of referral cases of homozygous Hb E for molecular testing of α -thalassemia in routine practice.
[Mh] Termos MeSH primário: Hemoglobina A2/genética
Hemoglobina E/genética
Homozigoto
Padrões de Herança
Talassemia alfa/diagnóstico
Talassemia alfa/genética
[Mh] Termos MeSH secundário: Adulto
Biomarcadores
Eletroforese Capilar
Índices de Eritrócitos
Feminino
Genótipo
Seres Humanos
Hidropisia Fetal/diagnóstico
Hidropisia Fetal/genética
Masculino
Mutação
Talassemia alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 9034-53-1 (Hemoglobin A2); 9034-61-1 (Hemoglobin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1111/ijlh.12677


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[PMID]:28413893
[Au] Autor:Leckngam P; Limweeraprajak E; Kiewkarnkha T; Tatu T
[Ad] Endereço:a Research Center for Hematology and Health Technology, Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences , Chiang Mai University , Chiang Mai , Thailand.
[Ti] Título:The Hb E (HBB: c.79G>A), Mean Corpuscular Volume, Mean Corpuscular Hemoglobin Cutoff Points in Double Heterozygous Hb E/- - α-Thalassemia-1 Carriers are Dependent on Hemoglobin Levels.
[So] Source:Hemoglobin;41(1):38-43, 2017 Jan.
[Is] ISSN:1532-432X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Identifying double heterozygosities in Hb E (HBB: c.79 G>A)/- - (Southeast Asian) (α-thalassemia-1) (α-thal-1) in patients first diagnosed as carrying Hb E is important in thalassemia control. Low Hb E, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (Hb) (MCH) levels have been observed in this double heterozygosity. However, the cutoff points of these parameters have never been systematically established. Here, we analyzed Hb E and red blood cell (RBC) parameters in 372 Hb E patients grouped by Hb levels, by the status of - - and -α (α-thal-2; rightward) deletions, to establish the cutoff points. Then, the established cutoff points were evaluated in 184 Hb E patients. It was found that the cutoff points of Hb E, MCV, MCH were significantly dependent on the Hb levels. In the group having Hb levels <10.0 g/dL, the cutoff points of Hb E, MCV and MCH were 21.2%, 64.9 fL and 21.0 pg, respectively, and were 25.6%, 72.8 fL and 23.9 pg, respectively, in the group having Hb levels 10.0-11.9 g/dL. Finally, in the group having Hb levels ≥12.0 g/dL, the cutoff points of Hb E, MCV and MCH were 27.1%, 76.7 fL and 25.3 pg, respectively. Thus, to screen for the double heterozygous Hb E/- - anomaly in patients initially diagnosed as carrying Hb E, the Hb levels must be taken into account in choosing the suitable cutoff points of these three parameters.
[Mh] Termos MeSH primário: Índices de Eritrócitos
Hemoglobina E/genética
Heterozigoto
Mutação
Talassemia alfa/sangue
Talassemia alfa/genética
Globinas beta/genética
[Mh] Termos MeSH secundário: Alelos
Códon
Seres Humanos
Curva ROC
Valores de Referência
Sensibilidade e Especificidade
Talassemia alfa/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon); 0 (beta-Globins); 9034-61-1 (Hemoglobin E)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1080/03630269.2017.1295984


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[PMID]:27900452
[Au] Autor:Klaihmon P; Phongpao K; Kheansaard W; Noulsri E; Khuhapinant A; Fucharoen S; Morales NP; Svasti S; Pattanapanyasat K; Chaichompoo P
[Ad] Endereço:Department of Immunology and Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Pran-Nok, Bangkok-Noi, Bangkok, 10170, Thailand.
[Ti] Título:Microparticles from splenectomized ß-thalassemia/HbE patients play roles on procoagulant activities with thrombotic potential.
[So] Source:Ann Hematol;96(2):189-198, 2017 Feb.
[Is] ISSN:1432-0584
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Thromboembolic events including cerebral thrombosis, deep vein thrombosis, and pulmonary embolism are major complications in ß-thalassemia. Damaged red blood cells and chronic platelet activation in splenectomized ß-thalassemia/HbE patients were associated with increased microparticles (MPs) releases into blood circulation. MPs are small membrane vesicles, which play important roles on coagulation. However, the role of MP in thalassemia is poorly understood. In this study, the effects of splenectomized-MPs on platelet activation and aggregation were investigated. The results showed that isolated MPs from fresh platelet-free plasma of patients and normal subjects directly induce platelet activation, platelet aggregation, and platelet-neutrophil aggregation in a dose-dependent manner. Interestingly, MPs obtained from splenectomized patients are more efficient in induction of platelet activation (P-selectin ) when compared to MPs from normal subjects (P < 0.05), tenfold lower than pathophysiological level, at 1:0.1 platelet MP ratio. Co-incubation of splenectomized-MPs with either normal-, non-splenectomized- or splenectomized-platelets at 1:10 platelet MP ratio increased platelet activation up to 5.1 ± 2.2, 5.6 ± 3.7, and 9.5 ± 3.0%, respectively, when normalized with individual baseline. These findings suggest that splenectomized patients were proned to be activated by MPs, and splenectomized-MPs could play an important role on chronic platelet activation and aggregation, leading to thrombus formation in ß-thalassemia/HbE patients.
[Mh] Termos MeSH primário: Coagulação Sanguínea/fisiologia
Micropartículas Derivadas de Células/metabolismo
Hemoglobina E/metabolismo
Esplenectomia
Trombose/sangue
Talassemia beta/sangue
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Agregação Plaquetária/fisiologia
Esplenectomia/tendências
Trombose/cirurgia
Adulto Jovem
Talassemia beta/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9034-61-1 (Hemoglobin E)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170201
[Lr] Data última revisão:
170201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1007/s00277-016-2885-6


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[PMID]:27834070
[Au] Autor:Jahng J; Yoon KH
[Ad] Endereço:Department of Gastroenterology, Wonkwang University Sanbon Hospital, Gunpo, Korea.
[Ti] Título:A Family With a Hemoglobin E Variant Including a Thai Immigrant Woman in Korea.
[So] Source:Ann Lab Med;37(1):71-73, 2017 Jan.
[Is] ISSN:2234-3814
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Mh] Termos MeSH primário: Hemoglobina E/genética
[Mh] Termos MeSH secundário: Sequência de Bases
DNA/metabolismo
Emigração e Imigração
Feminino
Homozigoto
Seres Humanos
Reação em Cadeia da Polimerase
República da Coreia
Análise de Sequência de DNA
Tailândia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
9007-49-2 (DNA); 9034-61-1 (Hemoglobin E)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161112
[St] Status:MEDLINE
[do] DOI:10.3343/alm.2017.37.1.71


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[PMID]:27765567
[Au] Autor:Sornjai W; Lithanatudom P; Erales J; Joly P; Francina A; Hacot S; Fucharoen S; Svasti S; Diaz JJ; Mertani HC; Smith DR
[Ad] Endereço:Institute of Molecular Bioscience, Mahidol University, Thailand.
[Ti] Título:Hypermethylation of 28S ribosomal RNA in ß-thalassemia trait carriers.
[So] Source:Int J Biol Macromol;94(Pt A):728-734, 2017 Jan.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ribosome biogenesis is the process of synthesis of the cellular ribosomes which mediate protein translation. Integral with the ribosomes are four cytoplasmic ribosomal RNAs (rRNAs) which show extensive post-transcriptional modifications including 2'-O-methylation and pseudouridylation. Several hereditary hematologic diseases including Diamond-Blackfan anemia have been shown to be associated with defects in ribosome biogenesis. Thalassemia is the most important hematologic inherited genetic disease worldwide, and this study examined the post-transcriptional ribose methylation status of three specific active sites of the 28S rRNA molecule at positions 1858, 4197 and 4506 of ß-thalassemia trait carriers and normal controls. Samples from whole blood and cultured erythroid cells were examined. Results showed that site 4506 was hypermethylated in ß-thalassemia trait carriers in both cohorts. Expression of fibrillarin, the ribosomal RNA methyltransferase as well as snoRNAs were additionally quantified by RT-qPCR and evidence of dysregulation was seen. Hemoglobin E trait carriers also showed evidence of dysregulation. These results provide the first evidence that ribosome biogenesis is dysregulated in ß-thalassemia trait carriers.
[Mh] Termos MeSH primário: Proteínas Cromossômicas não Histona/metabolismo
Hemoglobina E/metabolismo
Processamento Pós-Transcricional do RNA
RNA Ribossômico 28S/metabolismo
Ribossomos/metabolismo
Talassemia beta/metabolismo
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Proteínas Cromossômicas não Histona/genética
Expressão Gênica
Células-Tronco Hematopoéticas/metabolismo
Células-Tronco Hematopoéticas/patologia
Hemoglobina E/genética
Heterozigoto
Seres Humanos
Leucócitos Mononucleares/metabolismo
Leucócitos Mononucleares/patologia
Metilação
Cultura Primária de Células
Biossíntese de Proteínas
RNA Ribossômico 28S/genética
RNA Nucleolar Pequeno/genética
RNA Nucleolar Pequeno/metabolismo
Ribossomos/genética
Uridina Monofosfato/genética
Uridina Monofosfato/metabolismo
Talassemia beta/genética
Talassemia beta/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromosomal Proteins, Non-Histone); 0 (RNA, Ribosomal, 28S); 0 (RNA, Small Nucleolar); 0 (fibrillarin); 1157-60-4 (pseudouridylic acid); 9034-61-1 (Hemoglobin E); E2OU15WN0N (Uridine Monophosphate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE


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[PMID]:27750457
[Au] Autor:Lo TK
[Ad] Endereço:a Department of Obstetrics and Gynaecology , Queen Mary Hospital, The University of Hong Kong , Hong Kong SAR , China.
[Ti] Título:The pitfall of antenatal thalassaemia screening.
[So] Source:J Obstet Gynaecol;37(1):109-110, 2017 Jan.
[Is] ISSN:1364-6893
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cardiomegalia/diagnóstico
Complicações Hematológicas na Gravidez/diagnóstico
Diagnóstico Pré-Natal/métodos
Talassemia/diagnóstico
[Mh] Termos MeSH secundário: Cardiomegalia/embriologia
Cardiomegalia/genética
Feminino
Morte Fetal/etiologia
Genótipo
Hemoglobina E/análise
Hemoglobina E/genética
Hemoglobinas Anormais/análise
Hemoglobinas Anormais/genética
Seres Humanos
Gravidez
Complicações Hematológicas na Gravidez/genética
Talassemia/embriologia
Talassemia/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins, Abnormal); 9034-61-1 (Hemoglobin E); 9066-22-2 (Hemoglobin Constant Spring)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE
[do] DOI:10.1080/01443615.2016.1234448


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[PMID]:27718483
[Au] Autor:Pienthai N; Pornprasert S
[Ad] Endereço:Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai.
[Ti] Título:Lyophilized hemoglobin E control material for the dichlorophenol-indophenol (DCIP) test.
[So] Source:Clin Chem Lab Med;55(6):e108-e109, 2017 May 01.
[Is] ISSN:1437-4331
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: 2,6-Dicloroindofenol/química
Hemoglobina E/análise
[Mh] Termos MeSH secundário: Precipitação Química
Cromatografia Líquida de Alta Pressão/normas
Eletroforese Capilar/normas
Eritrócitos/citologia
Eritrócitos/metabolismo
Liofilização
Hemoglobina E/genética
Hemoglobina E/normas
Homozigoto
Seres Humanos
Estabilidade Proteica
Controle de Qualidade
Talassemia beta/diagnóstico
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
9034-61-1 (Hemoglobin E); C35QN2Z58B (2,6-Dichloroindophenol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE



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