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[PMID]:29178654
[Au] Autor:Creary S; Adan I; Stanek J; O'Brien SH; Chisolm DJ; Jeffries T; Zajo K; Varga E
[Ad] Endereço:Nationwide Children's Hospital, Columbus, Ohio.
[Ti] Título:Sickle cell trait knowledge and health literacy in caregivers who receive in-person sickle cell trait education.
[So] Source:Mol Genet Genomic Med;5(6):692-699, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite universal screening that detects sickle cell trait (SCT) in infancy, only 16% of Americans with SCT know their status. To increase SCT status awareness, effective education for patients and their families is needed. The objective of this study was to assess caregivers' SCT knowledge before and after an in-person SCT education session. METHODS: A trained educator provides in-person SCT education to caregivers of referred infants with SCT at Nationwide Children's Hospital. From August 2015 to July 2016, primarily English-speaking caregivers of infants with hemoglobin S-trait were recruited and completed a health literacy assessment and a SCT knowledge assessment (SCTKA) before and after receiving education. Caregivers repeated the SCTKA again after ≥6 months, if they could be contacted. RESULTS: Thirty-eight (38.1%) percent of 113 caregivers had high SCTKA scores (≥75%) before education but 90.3% achieved high scores after education. Caregivers with low SCTKA scores after education had significantly lower health literacy (P = 0.029) and baseline SCTKA scores (P = 0.003) compared to those with higher scores after education. At ≥6 months, caregivers' scores were significantly higher (P = 0.014) than baseline, but only 73.3% scored ≥75%. CONCLUSION: Our results suggest that caregivers' baseline SCT knowledge is low, improves with in-person education but may decline with time. Caregivers who do not achieve high SCT knowledge after education had lower health literacy and baseline knowledge. Future studies should determine if adapting in-person education to caregivers' health literacy and knowledge levels results in high and sustained SCT knowledge among all caregivers and more individuals who know their SCT status.
[Mh] Termos MeSH primário: Cuidadores/psicologia
Conhecimentos, Atitudes e Prática em Saúde
Traço Falciforme/enfermagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Conscientização
Estudos Transversais
Feminino
Seguimentos
Educação em Saúde
Alfabetização em Saúde
Hemoglobina Falciforme/genética
Seres Humanos
Lactente
Masculino
Meia-Idade
Satisfação Pessoal
Estudos Prospectivos
Traço Falciforme/diagnóstico
Traço Falciforme/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.327


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[PMID]:28887325
[Au] Autor:Fitzhugh CD; Cordes S; Taylor T; Coles W; Roskom K; Link M; Hsieh MM; Tisdale JF
[Ad] Endereço:Sickle Cell Branch, National Heart, Lung, and Blood Institute (NHLBI).
[Ti] Título:At least 20% donor myeloid chimerism is necessary to reverse the sickle phenotype after allogeneic HSCT.
[So] Source:Blood;130(17):1946-1948, 2017 Oct 26.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Novel curative therapies using genetic transfer of normal globin-producing genes into autologous hematopoietic stem cells (HSCs) are in clinical trials for patients with sickle cell disease (SCD). The percentage of transferred globin necessary to cure SCD is currently not known. In the setting of allogeneic nonmyeloablative HSC transplants (HSCTs), stable mixed chimerism is sufficient to reverse the disease. We regularly monitored 67 patients after HSCT. After initially robust engraftment, 3 of these patients experienced declining donor myeloid chimerism (DMC) levels with eventual return of disease. From this we discovered that 20% DMC is necessary to reverse the sickle phenotype. We subsequently developed a mathematical model to test the hypothesis that the percentage of DMC necessary is determined solely by differences between donor and recipient red blood cell (RBC) survival times. In our model, the required 20% DMC can be entirely explained by the large differences between donor and recipient RBC survival times. Our model predicts that the requisite DMC and therefore necessary level of transferred globin is lowest in patients with the highest reticulocyte counts and concomitantly shortened RBC lifespans.
[Mh] Termos MeSH primário: Anemia Falciforme/patologia
Anemia Falciforme/terapia
Transplante de Células-Tronco Hematopoéticas
Células Mieloides/patologia
Doadores de Tecidos
Quimeras de Transplante/metabolismo
[Mh] Termos MeSH secundário: Adulto
Hemoglobina Falciforme/metabolismo
Homozigoto
Seres Humanos
Fenótipo
Transplante Homólogo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2017-03-772392


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[PMID]:28736939
[Au] Autor:Habara AH; Shaikho EM; Steinberg MH
[Ad] Endereço:Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, 02118.
[Ti] Título:Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents.
[So] Source:Am J Hematol;92(11):1233-1242, 2017 Nov.
[Is] ISSN:1096-8652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fetal hemoglobin (HbF) has well-known tempering effects on the symptoms of sickle cell disease and its levels vary among patients with different haplotypes of the sickle hemoglobin gene. Compared with sickle cell anemia haplotypes found in patients of African descent, HbF levels in Saudi and Indian patients with the Arab-Indian (AI) haplotype exceed that in any other haplotype by nearly twofold. Genetic association studies have identified some loci associated with high HbF in the AI haplotype but these observations require functional confirmation. Saudi patients with the Benin haplotype have HbF levels almost twice as high as African patients with this haplotype but this difference is unexplained. Hydroxyurea is still the only FDA approved drug for HbF induction in sickle cell disease. While most patients treated with hydroxyurea have an increase in HbF and some clinical improvement, 10 to 20% of adults show little response to this agent. We review the genetic basis of HbF regulation focusing on sickle cell anemia in Saudi Arabia and discuss new drugs that can induce increased levels of HbF.
[Mh] Termos MeSH primário: Anemia Falciforme/sangue
Anemia Falciforme/genética
Hemoglobina Fetal/genética
[Mh] Termos MeSH secundário: Anemia Falciforme/tratamento farmacológico
Anemia Falciforme/metabolismo
Animais
Sítios de Ligação
Hemoglobina Fetal/metabolismo
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Haplótipos
Hemoglobina Falciforme/genética
Seres Humanos
MicroRNAs/genética
MicroRNAs/metabolismo
Terapia de Alvo Molecular
Família Multigênica
Motivos de Nucleotídeos
Fenótipo
Ligação Proteica
Sequências Reguladoras de Ácido Nucleico
Fatores de Transcrição/metabolismo
Globinas beta/genética
gama-Globinas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hemoglobin, Sickle); 0 (MicroRNAs); 0 (Transcription Factors); 0 (beta-Globins); 0 (gamma-Globins); 9034-63-3 (Fetal Hemoglobin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE
[do] DOI:10.1002/ajh.24872


  4 / 2859 MEDLINE  
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[PMID]:28700924
[Au] Autor:Lu L; Li H; Bian X; Li X; Karniadakis GE
[Ad] Endereço:Division of Applied Mathematics, Brown University, Providence, Rhode Island.
[Ti] Título:Mesoscopic Adaptive Resolution Scheme toward Understanding of Interactions between Sickle Cell Fibers.
[So] Source:Biophys J;113(1):48-59, 2017 Jul 11.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding of intracellular polymerization of sickle hemoglobin (HbS) and subsequent interaction with the membrane of a red blood cell (RBC) is important to predict the altered morphologies and mechanical properties of sickle RBCs in sickle cell anemia. However, modeling the integrated processes of HbS nucleation, polymerization, HbS fiber interaction, and subsequent distortion of RBCs is challenging as they occur at multispatial scales, ranging from nanometers to micrometers. To make progress toward simulating the integrated processes, we propose a hybrid HbS fiber model, which couples fine-grained and coarse-grained HbS fiber models through a mesoscopic adaptive resolution scheme (MARS). To this end, we apply a microscopic model to capture the dynamic process of polymerization of HbS fibers, while maintaining the mechanical properties of polymerized HbS fibers by the mesoscopic model, thus providing a means of bridging the subcellular and cellular phenomena in sickle cell disease. At the subcellular level, this model can simulate HbS polymerization with preexisting HbS nuclei. At the cellular level, if combined with RBC models, the generated HbS fibers could be applied to study the morphologies and membrane stiffening of sickle RBCs. One important feature of the MARS is that it can be easily employed in other particle-based multiscale simulations where a dynamic coarse-graining and force-blending method is required. As demonstrations, we first apply the hybrid HbS fiber model to simulate the interactions of two growing fibers and find that their final configurations depend on the orientation and interaction distance between two fibers, in good agreement with experimental observations. We also model the formation of fiber bundles and domains so that we explore the mechanism that causes fiber branching.
[Mh] Termos MeSH primário: Hemoglobina Falciforme/metabolismo
Modelos Moleculares
[Mh] Termos MeSH secundário: Anemia Falciforme/sangue
Anemia Falciforme/metabolismo
Anemia Falciforme/patologia
Simulação por Computador
Eritrócitos/metabolismo
Eritrócitos/patologia
Hemoglobina Falciforme/química
Seres Humanos
Polimerização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28666277
[Au] Autor:Bottin C; Racine J; Robert MP; Cohen SY; Merle BMJ; Jung C; Miere A; Caillaux V; Souied EH; Zambrowski O
[Ad] Endereço:Department of Ophthalmology, Centre Hospitalier Intercommunal, Créteil, France.
[Ti] Título:Electroretinogram Findings in Early-Stage Sickle Cell Retinopathy According to Hemoglobin Type.
[So] Source:Invest Ophthalmol Vis Sci;58(7):3262-3267, 2017 Jun 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Although extensive clinical research has been performed on structural analysis of sickle cell (SC) retinopathy, functional aspects have been poorly investigated. Our purpose was to report full-field electroretinogram (ffERG) findings in patients with early SC retinopathy according to the following hemoglobin types: HbSS or HbSC (homozygous or heterozygous mutations, respectively). Methods: In this monocentric retrospective observational study, patients affected by nonproliferative SC retinopathy were included from November 2014 to April 2016. Patients were separated into one of the following three groups: HbSS, HbSC, and control. All groups underwent full ophthalmologic examination (fundus examination) and ffERG. For SC patients, additional imaging testing was also performed (fluorescein angiography and spectral domain optical coherence tomography). Results: A total of 24 eyes from 12 patients (6 HbSS and 6 HbSC) and 12 eyes from 6 controls were included. The HbSS group exhibited a dramatic decrease of the b-wave amplitudes for all dark-adapted (DA) ffERG responses when compared with the control group (P = 0.02, P = 0.003, P = 0.005, respectively, after DA 0.01, DA 3.0, and DA 10.0 cd.s.m-2 stimulations) and decreased a-wave amplitudes for light-adapted responses (P = 0.03 after light-adapted 3.0 cd.s.m-2 stimulations). The a-Wave amplitudes were significantly reduced for all dark-adapted and light-adapted responses in HbSC group compared to the control group (P = 0.03, P = 0.01, P = 0.03, respectively, after DA 3.0, DA 10.0, and light-adapted 3.0 cd.s.m-2 stimulations). The HbSS+HbSC groups presented decreased a-wave amplitudes for DA and light-adapted responses and decreased b-wave amplitude after DA 0.01 and 10.0 cd.s.m-2 stimulations when compared to the control group. Conclusions: These results could suggest an early involvement of the inner retinal cells in the disease process in HbSS patients and of the outer retinal cells in HbSC patients. This could provide new insights on the pathophysiology of the retinal affection in HbSS/HbSC SC disease.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Doenças Retinianas/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anemia Falciforme/sangue
Estudos de Casos e Controles
Eletrorretinografia
Feminino
Angiofluoresceinografia
Hemoglobina Falciforme/análise
Seres Humanos
Masculino
Meia-Idade
Doenças Retinianas/etiologia
Estudos Retrospectivos
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20719


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[PMID]:28586884
[Au] Autor:Lacy ME; Wellenius GA; Wu WC
[Ad] Endereço:Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island.
[Ti] Título:Measurement of Hemoglobin A1c in Patients With Sickle Cell Trait-Reply.
[So] Source:JAMA;317(21):2237-2238, 2017 06 06.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hemoglobina A Glicada
Traço Falciforme
[Mh] Termos MeSH secundário: Anemia Falciforme
Testes Hematológicos
Hemoglobina Falciforme
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.4646


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[PMID]:28586882
[Au] Autor:Rohlfing C; Hanson S; Little RR
[Ad] Endereço:Department of Pathology and Anatomical Sciences, University of Missouri, Columbia.
[Ti] Título:Measurement of Hemoglobin A1c in Patients With Sickle Cell Trait.
[So] Source:JAMA;317(21):2237, 2017 06 06.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hemoglobina A Glicada
Traço Falciforme
[Mh] Termos MeSH secundário: Anemia Falciforme
Testes Hematológicos
Hemoglobina Falciforme
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.4643


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[PMID]:28544309
[Au] Autor:Woods D; Hayashi RJ; Binkley MM; Sparks GW; Hulbert ML
[Ad] Endereço:Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
[Ti] Título:Increased complications of chronic erythrocytapheresis compared with manual exchange transfusions in children and adolescents with sickle cell disease.
[So] Source:Pediatr Blood Cancer;64(11), 2017 Nov.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Children and adolescents with sickle cell disease (SCD) are at high risk of strokes and are frequently treated with red blood cell (RBC) transfusions. The goal is to suppress hemoglobin (Hb) S while minimizing transfusion-induced iron overload. RBCs may be given via simple transfusion, manual exchange transfusion (MET), or erythrocytapheresis (aRBCX). Chronic transfusion practices vary among institutions. METHODS: This single-institution, retrospective cohort study compares Hb S control and therapy complication rates between MET and aRBCX in a cohort of children and adolescents with SCD and stroke during a 5-year period from 2008 through 2012. Duration and mode of transfusion therapy, achievement of Hb S suppression goal, iron burden by ferritin levels, and catheter complications were evaluated. RESULTS: Thirty-seven children were included in analysis. The prevalence of catheter complications was 75% in aRBCX recipients compared with 0% in MET recipients (P < 0.001). There was no significant difference between modalities in achieving Hb S suppression or ferritin goals, but those receiving aRBCX had a greater likelihood of discontinuing chelation therapy. Among aRBCX recipients, adherence to >90% of transfusion appointments was associated with achieving Hb S suppression goals. CONCLUSION: aRBCX may have increased complication risks compared with MET for chronic transfusion therapy in SCD. Risks and benefits of aRBCX and MET should be considered when selecting a chronic transfusion modality. Transfusion therapy modalities should be compared in prospective studies for stroke prevention in children with SCD.
[Mh] Termos MeSH primário: Anemia Falciforme/complicações
Transfusão de Eritrócitos/efeitos adversos
Transfusão Total/efeitos adversos
Sobrecarga de Ferro/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anemia Falciforme/terapia
Criança
Pré-Escolar
Feminino
Seguimentos
Hemoglobina Falciforme/metabolismo
Seres Humanos
Masculino
Prognóstico
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26635


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[PMID]:28541483
[Au] Autor:Sepúlveda N; Manjurano A; Campino SG; Lemnge M; Lusingu J; Olomi R; Rockett KA; Hubbart C; Jeffreys A; Rowlands K; Clark TG; Riley EM; Drakeley CJ; MalariaGEN Consortium
[Ad] Endereço:London School of Hygiene and Tropical Medicine.
[Ti] Título:Malaria Host Candidate Genes Validated by Association With Current, Recent, and Historical Measures of Transmission Intensity.
[So] Source:J Infect Dis;216(1):45-54, 2017 Jul 01.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Human malaria susceptibility is determined by multiple genetic factors. It is unclear, however, which genetic variants remain important over time. Methods: Genetic associations of 175 high-quality polymorphisms within several malaria candidate genes were examined in a sample of 8096 individuals from northeast Tanzania using altitude, seroconversion rates, and parasite rates as proxies of historical, recent, and current malaria transmission intensity. A principal component analysis was used to derive 2 alternative measures of overall malaria propensity of a location across different time scales. Results: Common red blood cell polymorphisms (ie, hemoglobin S, glucose-6-phosphate dehydrogenase, and α-thalassemia) were the only ones to be associated with all 3 measures of transmission intensity and the first principal component. Moderate associations were found between some immune response genes (ie, IL3 and IL13) and parasite rates, but these could not be reproduced using the alternative measures of malaria propensity. Conclusions: We have demonstrated the potential of using altitude and seroconversion rate as measures of malaria transmission capturing medium- to long-term time scales to detect genetic associations that are likely to persist over time. These measures also have the advantage of minimizing the deleterious effects of random factors affecting parasite rates on the respective association signals.
[Mh] Termos MeSH primário: Estudos de Associação Genética
Interações Hospedeiro-Parasita/genética
Malária Falciparum/genética
Malária Falciparum/transmissão
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Estudos Transversais
Eritrócitos
Feminino
Glucosefosfato Desidrogenase/genética
Hemoglobina Falciforme/genética
Seres Humanos
Lactente
Interleucina-3/genética
Modelos Lineares
Masculino
Meia-Idade
Análise Multivariada
Plasmodium falciparum
Polimorfismo de Nucleotídeo Único
Prevalência
Análise de Componente Principal
Reprodutibilidade dos Testes
Tanzânia
Adulto Jovem
Talassemia alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobin, Sickle); 0 (IL3 protein, human); 0 (Interleukin-3); EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix250


  10 / 2859 MEDLINE  
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[PMID]:28520780
[Au] Autor:Bond M; Hunt B; Flynn B; Huhtinen P; Ware R; Richards-Kortum R
[Ad] Endereço:Department of Bioengineering, Rice University, Houston, TX, United States of America.
[Ti] Título:Towards a point-of-care strip test to diagnose sickle cell anemia.
[So] Source:PLoS One;12(5):e0177732, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A rapid test to identify patients with sickle cell disease could have important benefits in low-resource settings. Sickle cell anemia (SCA) affects about 300,000 newborns each year, the majority of whom are born in sub-Saharan Africa. Low-cost therapies are available to treat SCA, but most countries in sub-Saharan Africa lack robust neonatal screening programs needed to identify patients in need of treatment. To address this need, we developed and evaluated a competitive lateral flow assay that identifies patients with SCA (genotype HbSS) in 15 minutes using undiluted whole blood. A small volume of blood (0.5 µL- 3 µL) is mixed with antibody-coated blue latex beads in a tube and applied to the strip. Strips are then placed in a well of running buffer and allowed to run for 10 minutes. Laboratory evaluation with samples containing different proportions of hemoglobin A (HbA) and hemoglobin S (HbS) indicated that the test should enable identification of SCA patients but not persons with sickle cell trait (SCT). We evaluated the test using 41 samples from individuals with SCA, SCT, and normal blood. With visual inspection or quantitative analysis, we found a 98% accuracy when differentiating SCA from normal and SCT samples as a group (90% sensitivity and 100% specificity for identifying SCA). This work demonstrates important steps towards making a lateral flow test for hemoglobinopathies more appropriate for point-of-care use; further work is needed before the test is appropriate for clinical use.
[Mh] Termos MeSH primário: Anemia Falciforme/sangue
Testes Imediatos/economia
Testes Sorológicos/métodos
[Mh] Termos MeSH secundário: África ao Sul do Saara
Anticorpos Imobilizados/imunologia
Hemoglobina Falciforme/imunologia
Seres Humanos
Recém-Nascido
Microesferas
Testes Imediatos/normas
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Testes Sorológicos/economia
Testes Sorológicos/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Antibodies, Immobilized); 0 (Hemoglobin, Sickle)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177732



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde