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[PMID]:28412826
[Au] Autor:Jalaeikhoo H; Soleymani M; Rajaeinejad M; Keyhani M
[Ad] Endereço:AJA Cancer Research Center (ACRC), AJA University of Medical Sciences, Tehran, Iran.
[Ti] Título:Prevalence of Human T-lymphotropic virus type 1 (HTLV-1) Infection in Patients with Hematologic Disorders and Non-Hematologic Malignancies in a Tertiary Referral Hospital.
[So] Source:Arch Iran Med;20(4):224-228, 2017 Apr.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) was the first retrovirus identified in human. The current evidence is quite scarce regarding the potential role of HTLV-1 in pathogenesis of hematologic disorders and non-hematologic malignancies. OBJECTIVES: The aim of this study is to evaluate the prevalence of HTLV-1 infection in patients with hematologic disorders and non-hematologic malignancies. METHODS: This cross-sectional study was conducted on 505 cases of definite diagnosis of hematologic disorders including malignancies as well as non-malignant disorders such as polycythemia and myelofibrosis and non-hematologic malignancies referred to the hematology and medical oncology ward at Army Hospital 501 from January 2015 to January 2016. A 3-mL blood specimen was collected from each patient and tested for the presence of anti-HTLV-1 antibodies using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using SPSS software package version 19 (IBM, New York, USA). Data are presented as mean ± SD if normally distributed and otherwise as median (range). RESULTS: Totally, 242 (48%) males and 263 (52%) females with a mean ± SD age of 52.09 ± 16.24 were enrolled in this study. In total, there were 9 (1.78%) cases positive for HTLV-1 infection including 4 males and 5 females. Seven out of 287 (2.4%) patients with hematologic disorders were infected by HTLV-1. In non-hematologic malignancies, 2 out of 211 cases were positive (0.9%). There was no HTLV-1 positive case in 7 patients with both hematologic and non-hematologic disorders. The difference in HTLV-1 infection prevalence between patients with hematologic disorders and non-hematologic malignancies was not statistically significant different (P = 0.31). There was no association between sex and transfusion history with HTLV-1 infection in this population (P = 0.9 and 0.7, respectively). CONCLUSIONS: Our study revealed that the prevalence of HTLV-1 in hematologic disorders is higher than the general population. Further larger prospective studies are recommended to corroborate the current evidence.
[Mh] Termos MeSH primário: Anticorpos Anti-HTLV-I/sangue
Infecções por HTLV-I/epidemiologia
Doenças Hematológicas/complicações
Neoplasias/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Doadores de Sangue
Western Blotting
Estudos Transversais
Feminino
Vírus 1 Linfotrópico T Humano
Seres Humanos
Irã (Geográfico)
Masculino
Meia-Idade
Centros de Atenção Terciária
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HTLV-I Antibodies)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:0172004/AIM.007


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[PMID]:28343818
[Au] Autor:Campos KR; Gonçalves MG; Costa NA; Caterino-de-Araujo A
[Ad] Endereço:Secretaria de Estado da Saúde de São Paulo, Instituto Adolfo Lutz, Centro de Imunologia, São Paulo, SP, Brazil.
[Ti] Título:Comparative performances of serologic and molecular assays for detecting human T lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) in patients infected with human immunodeficiency virus type 1 (HIV-1).
[So] Source:Braz J Infect Dis;21(3):297-305, 2017 May - Jun.
[Is] ISSN:1678-4391
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The present study evaluated several techniques currently available (commercial kits and in-house assays) for diagnosing human T lymphotropic viruses types 1 and 2 in two groups of patients enrolled at HIV/AIDS specialized care services in São Paulo: Group 1 (G1), n=1608, 1237 male/371 female, median age 44.3 years old, majority using highly active antiretroviral therapy (HAART); G2, n=1383, 930 male/453 female, median age of 35.6 years old, majority HAART naïve. Enzyme immunoassays [(EIA) Murex and Gold ELISA] were employed for human T lymphotropic viruses types 1 and 2 screening; Western blotting (WB), INNO-LIA (LIA), real-time PCR pol (qPCR), and nested-PCR-RFLP (tax) were used to confirm infection. Samples were considered human T lymphotropic viruses types 1 and 2 positive when there was reactivity using at least one of the four confirmatory assays. By serological screening, 127/2991 samples were positive or borderline, and human T lymphotropic virus infection was confirmed in 108 samples (three EIA-borderline): 56 human T lymphotropic virus type 1 [G1 (27)+G2 (29)]; 45 human T lymphotropic virus type 2 [G1 (21)+G2 (24)]; one human T lymphotropic virus type 1+human T lymphotropic virus type 2 (G2); six human T lymphotropic virus [G1 (2)+G2 (4)]. Although there were differences in group characteristics, human T lymphotropic viruses types 1 and 2 prevalence was similar [3.1% (G1) and 4.2% (G2), p=0.113]. The overall sensitivities of LIA, WB, qPCR, and PCR-RFLP were 97.2%, 82.4%, 68.9%, and 68.4%, respectively, with some differences among groups, likely due to the stage of human T lymphotropic virus infection and/or HAART duration. Indeterminate immunoblotting results were detected in G2, possibly due to the seroconversion period. Negative results in molecular assays could be explained by the use of HAART, the occurrence of defective provirus and/or the low circulating proviral load. In conclusion, when determining the human T lymphotropic virus infection, the findings highlight that there is a need to consider the blood samples with borderline results in screening assays. Of all the tested assays, LIA was the assay of choice for detecting human T lymphotropic virus type 1 and human T lymphotropic virus type 2 in human immunodeficiency virus type 1-infected patients.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Infecções por HTLV-I/diagnóstico
Infecções por HTLV-II/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Western Blotting
DNA Viral/genética
Ensaio de Imunoadsorção Enzimática
Feminino
Anticorpos Anti-HTLV-I/sangue
Infecções por HTLV-I/complicações
Anticorpos Anti-HTLV-II/sangue
Infecções por HTLV-II/complicações
Seres Humanos
Masculino
Reação em Cadeia da Polimerase em Tempo Real
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:26899860
[Au] Autor:Salehi M; Shokouhi Mostafavi SK; Ghasemian A; Gholami M; Kazemi-Vardanjani A; Rahimi MK
[Ad] Endereço:Medical Diagnostic Laboratory of Neyshabour, Center of Medical, Pathological and Genetic Diagnostic Services, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran.
[Ti] Título:Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014.
[So] Source:Iran Biomed J;21(1):57-60, 2017 Jan.
[Is] ISSN:2008-823X
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014. METHODS: A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer's instructions. RESULTS: The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants. CONCLUSION: Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.
[Mh] Termos MeSH primário: Anticorpos Anti-HTLV-I/sangue
Infecções por HTLV-I/epidemiologia
Anticorpos Anti-HTLV-II/sangue
Infecções por HTLV-II/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Feminino
Infecções por HTLV-I/virologia
Infecções por HTLV-II/virologia
Seres Humanos
Lactente
Irã (Geográfico)/epidemiologia
Masculino
Prevalência
Estudos Soroepidemiológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160223
[St] Status:MEDLINE


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[PMID]:28329538
[Au] Autor:Gittler J; Martires K; Terushkin V; Brinster N; Ramsay D
[Ad] Endereço:Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
[Ti] Título:Primary cutaneous smoldering adult T-cell leukemia/ lymphoma.
[So] Source:Dermatol Online J;22(12), 2016 Dec 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HTLV-1 is a virus that is endemic in southwesternJapan and the Caribbean and has been implicatedin the development of ATLL. ATLL, which is anuncommon malignant condition of peripheralT-lymphocytes, is characterized by four clinicalsubtypes, which include acute, lymphomatous,chronic, and smoldering types, that are based onLDH levels, calcium levels, and extent of organinvolvement. We present a 52-year- old woman withpruritic patches with scale on the buttocks and withtender, hyperpigmented macules and papules oftwo-years duration. Histopathologic examinationwas suggestive of mycosis fungoides, laboratoryresults showed HTLV-I and II, and the patient wasdiagnosed with primary cutaneous ATLL. We reviewthe literature on HTLV-1 and ATLL and specifically theprognosis of cutaneous ATLL. The literature suggeststhat a diagnosis of ATLL should be considered amongpatients of Caribbean origin or other endemicareas with skin lesions that suggest a cutaneousT-cell lymphoma, with clinicopathologic features ofmycosis fungoides. Differentiation between ATLLand cutaneous T-cell lymphoma is imperative as theyhave different prognoses and treatment approaches.
[Mh] Termos MeSH primário: Anemia Refratária com Excesso de Blastos/diagnóstico
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Anemia Refratária com Excesso de Blastos/patologia
Anemia Refratária com Excesso de Blastos/virologia
Western Blotting
Ensaio de Imunoadsorção Enzimática
Feminino
Anticorpos Anti-HTLV-I/imunologia
Anticorpos Anti-HTLV-II/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Vírus 2 Linfotrópico T Humano/imunologia
Seres Humanos
Leucemia-Linfoma de Células T do Adulto/patologia
Leucemia-Linfoma de Células T do Adulto/virologia
Meia-Idade
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/virologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:26589659
[Au] Autor:Miller L
[Ad] Endereço:a Clinical Research & Regulatory Affairs , MP Biomedicals , Santa Ana , CA , USA.
[Ti] Título:Profile of the MP Diagnostics HTLV Blot 2.4 test: a supplemental assay for the confirmation and differentiation of antibodies to HTLV-1 and HTLV-2.
[So] Source:Expert Rev Mol Diagn;16(2):135-45, 2016.
[Is] ISSN:1744-8352
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As the first US FDA-approved assay for supplemental HTLV testing, the MP Diagnostics HTLV Blot 2.4 is an effective and efficient method for confirming and differentiating HTLV type infection in repeatedly reactive samples. Novel and patented antigens added increased sensitivity in identifying specimens from infected individuals while differentiating those from uninfected individuals with false reactivity.
[Mh] Termos MeSH primário: Anticorpos Anti-HTLV-I/sangue
Anticorpos Anti-HTLV-II/sangue
Vírus 1 Linfotrópico T Humano/imunologia
Vírus 2 Linfotrópico T Humano/imunologia
Kit de Reagentes para Diagnóstico/normas
Testes Sorológicos/métodos
[Mh] Termos MeSH secundário: Anticorpos Anti-HTLV-I/imunologia
Anticorpos Anti-HTLV-II/imunologia
Seres Humanos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151122
[St] Status:MEDLINE
[do] DOI:10.1586/14737159.2016.1123622


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[PMID]:26867355
[Au] Autor:Sari Y; Haryati S; Raharjo I; Prasetyo AA
[Ti] Título:TOXOPLASMA AND VIRAL ANTIBODIES AMONG HIV PATIENTS AND INMATES IN CENTRAL JAVA, INDONESIA.
[So] Source:Southeast Asian J Trop Med Public Health;46(6):977-85, 2015 Nov.
[Is] ISSN:0125-1562
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:In Indonesia, Toxoplasma and its associations with blood-borne viruses have been poorly studied. In order to study the association between anti-Toxoplasma antibodies and blood-borne viral antibodies, blood samples from 497 participants (375 inmates from four prisons in Central Java, Indonesia and 122 HIV patients at a Voluntary Counseling and Testing Clinic in Surakarta, Indonesia) were tested for serological markers of Toxoplasma, human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV) and human T-lymphotropic virus types I and II (HTLV-1/2). Anti-Toxoplasma IgG and IgM positivity rates were 41.6% and 3.6%, respectively. One point two percent of participants was positive for both anti-Toxoplasma IgG and IgM antibodies. Sixteen point five percent, 11.3%, 2.6% and 2.8% of participants were positive for anti- Toxoplasma IgG combined with anti-HCV antibodies, anti-Toxoplasma IgG combined with anti-HIV antibodies, anti-Toxoplasma IgM combined with anti-HIV antibodes and anti-Toxoplasma IgG combined with both anti-HIV and anti-HCV antibodies, respectively. Anti-Toxoplasma IgM seropositivity was associated with anti-HIV (aOR = 4.3; 95% CI: 1.112-16.204, p = 0.034). Anti-Toxoplasma IgG antibodies were associated with anti-HCV (aOR = 2.8; 95% CI: 1.749-4.538, p < 0.001) and history of injection drug use (aOR = 3.1; 95% CI: 1.905-5.093, p < 0.001). In conclusion, we recommend patients with HIV, HCV infection and injection drug users should be screened for Toxoplasma infection in Indonesia.
[Mh] Termos MeSH primário: Anticorpos Antivirais/imunologia
Infecções por HIV/epidemiologia
Infecções por HTLV-I/epidemiologia
Infecções por HTLV-II/epidemiologia
Hepatite Viral Humana/epidemiologia
Toxoplasmose/epidemiologia
[Mh] Termos MeSH secundário: Anticorpos Antiprotozoários
Coinfecção/epidemiologia
Coinfecção/imunologia
Feminino
Anticorpos Anti-HTLV-I/imunologia
Infecções por HTLV-I/imunologia
Anticorpos Anti-HTLV-II/imunologia
Infecções por HTLV-II/imunologia
Anticorpos Anti-Hepatite/imunologia
Anticorpos Anti-Hepatite B/imunologia
Anticorpos Anti-Hepatite C/imunologia
Vírus Delta da Hepatite/imunologia
Hepatite Viral Humana/imunologia
Seres Humanos
Imunoglobulina G/imunologia
Imunoglobulina M/imunologia
Indonésia/epidemiologia
Masculino
Prisioneiros
Estudos Soroepidemiológicos
Toxoplasma/imunologia
Toxoplasmose/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Antibodies, Viral); 0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies); 0 (Hepatitis Antibodies); 0 (Hepatitis B Antibodies); 0 (Hepatitis C Antibodies); 0 (Immunoglobulin G); 0 (Immunoglobulin M)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160212
[Lr] Data última revisão:
160212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160213
[St] Status:MEDLINE


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[PMID]:26849695
[Au] Autor:Domínguez MC; Salcedo M; García-Vallejo F
[Ad] Endereço:Laboratorio de Biología Molecular y Patogénesis, Departamento de Ciencias Fisiológicas, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali, Colombia.
[Ti] Título:Serological and virological evaluation of human T-lymphotropic virus type 1 infection in family groups from Tumaco, Colombia.
[So] Source:Biomedica;35(3):337-46, 2015 Jul-Sep.
[Is] ISSN:0120-4157
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: To date there has been no statistical evaluation of the profiles of immunoglobulin classes and viral replication as variables in the study of HTLV-1 infection and circulation among families in virus-endemic areas of Colombia. OBJECTIVE: To evaluate the correlation of several immunological and molecular characteristics with the transmission and circulation of HTLV-1 among families in the town of Tumaco. MATERIALS AND METHODS: Plasma levels of HTLV-1 specific immunoglobulin classes IgG, IgM and IgA1, as well as IgG and sIgA in oral fluids, were calculated for 32 members of 10 family groups from Tumaco in which the mother and at least one child were infected with the virus. Levels of the different immunoglobulin classes were correlated with viral RNA circulating in plasma or oral fluids and the proviral burden as detected by RT-PCR. RESULTS: Significant differences were determined between mothers and carrier children for immunoglobulin levels (p=0.037) and proviral burden (p=0.002). The overall estimate of IgG in plasma and sIgA in oral fluids could be correlated with the circulation of free viral RNA in both fluids and high proviral burden, and associated with HAM/TSP mothers. The detection of anti- tax IgG in plasma revealed differences between HAM/TSP mothers and their offspring. CONCLUSION: The study of immunological and molecular variables permitted the analysis of HTLV-1 circulation among families of Tumaco. The strong correlation between levels of IgM specific for the virus and viral RNA circulating in fluids indirectly confirmed the transmission of HTLV-1 among families.
[Mh] Termos MeSH primário: Saúde da Família
Anticorpos Anti-HTLV-I/análise
Infecções por HTLV-I/epidemiologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
RNA Viral/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
Aleitamento Materno/efeitos adversos
Criança
Pré-Escolar
Colômbia/epidemiologia
Estudos Transversais
Doenças Endêmicas
Feminino
Anticorpos Anti-HTLV-I/sangue
Infecções por HTLV-I/imunologia
Infecções por HTLV-I/transmissão
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/genética
Vírus 1 Linfotrópico T Humano/imunologia
Seres Humanos
Transmissão Vertical de Doença Infecciosa
Masculino
Meia-Idade
Mães
Provírus/isolamento & purificação
RNA Viral/sangue
Estudos Soroepidemiológicos
Viremia/epidemiologia
Viremia/imunologia
Viremia/virologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (RNA, Viral)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE


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[PMID]:26691361
[Au] Autor:Niazi SK; Bhatti FA; Salamat N
[Ad] Endereço:Department of Screening, Armed Forces Institute of Transfusion (AFIT), Rawalpindi.
[Ti] Título:Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening.
[So] Source:J Coll Physicians Surg Pak;25(12):874-7, 2015 Dec.
[Is] ISSN:1681-7168
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the seroprevalence of Human T-cell Lymphotropic Virus-1/2 (HTLV-1/2) in blood donors in Northern Pakistan. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Armed Forces Institute of Transfusion, Rawalpindi, from July to August 2013. METHODOLOGY: A total of 2100 blood donors were screened for anti-HTLV-1/2 antibodies during the study period, in a pool of six, on a highly sensitive, Chemiluminiscent Microparticle Immunoassay (CMIA) based system. The screening test-reactive donors were recalled, counseled and interviewed, and a fresh sample was obtained for confirmatory testing. Confirmation was performed using additional immunoassays including Line Immunoassay (LIA); with additional testing for HTLV-1 pvDNAPCR. Frequency and percentages were determined. RESULTS: Four donors (0.19%) were repeatedly screening test-reactive and were subsequently confirmed to be HTLV-1 infected by line immunoassay and HTLV-1 pvDNAPCR. All four donors were male with mean age of 27 ± 6.27 years. Two (50%) of the positive donors gave history of Multiple Sexual Partners (MSP). CONCLUSION: HTLV-1 seroprevalence in Northern Pakistan blood donors was determined to be 0.19%. Large scale studies, including the cost effectiveness of screening blood donations for anti-HTLV-1/2 in Pakistan, are recommended.
[Mh] Termos MeSH primário: Doadores de Sangue/estatística & dados numéricos
Anticorpos Anti-HTLV-I/sangue
Anticorpos Anti-HTLV-II/sangue
Vírus 1 Linfotrópico T Humano/imunologia
Vírus 2 Linfotrópico T Humano/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Transfusão de Sangue
Estudos Transversais
Seleção do Doador
Feminino
Infecções por HTLV-I/sangue
Infecções por HTLV-I/epidemiologia
Infecções por HTLV-II/sangue
Infecções por HTLV-II/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Paquistão/epidemiologia
Reação em Cadeia da Polimerase
Provírus/genética
Estudos Soroepidemiológicos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HTLV-I Antibodies); 0 (HTLV-II Antibodies)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE
[do] DOI:12.2015/JCPSP.874877


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[PMID]:26631889
[Au] Autor:Yamakawa H; Yoshida M; Yabe M; Ishikawa T; Takagi M; Tanoue S; Sano K; Nishiwaki K; Sato S; Shimizu Y; Kuwano K
[Ad] Endereço:Department of Internal Medicine, Division of Respiratory Medicine, Jikei University School of Medicine, Kashiwa Hospital, Japan.
[Ti] Título:Human T-cell Lymphotropic Virus Type-1 (HTLV-1)-associated Bronchioloalveolar Disorder Presenting with Mosaic Perfusion.
[So] Source:Intern Med;54(23):3039-43, 2015.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Human T-cell lymphotropic virus type-1 (HTLV-1)-associated bronchioloalveolar disorder (HABA) is a specific state with chronic and progressive respiratory symptoms caused by bronchiolar or alveolar disorder characterized by smoldering adult T-cell leukemia or the HTLV-I carrier state. We herein report a rare case of HABA with an initial presentation of mosaic perfusion in the lung. The diagnosis was made according to the results of a flow cytometry analysis of the bronchoalveolar lavage fluid and pathological findings. Clinicians must be careful to recognize that mosaic perfusion may be a radiological finding of HABA.
[Mh] Termos MeSH primário: Bronquiolite/imunologia
Anticorpos Anti-HTLV-I/análise
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Leucemia-Linfoma de Células T do Adulto/imunologia
[Mh] Termos MeSH secundário: Adulto
Bronquiolite/complicações
Bronquiolite/patologia
Líquido da Lavagem Broncoalveolar/química
Infecções por HTLV-I/complicações
Infecções por HTLV-I/patologia
Seres Humanos
Leucemia-Linfoma de Células T do Adulto/complicações
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HTLV-I Antibodies)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151203
[Lr] Data última revisão:
151203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.54.4717


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[PMID]:25948358
[Au] Autor:Ando R; Nishikawa N; Tsujii T; Iwaki H; Yabe H; Nagai M; Nomoto M
[Ad] Endereço:Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Japan.
[Ti] Título:Human T-lymphotropic virus type-I (HTLV-I)-associated myelopathy with bulbar palsy-type amyotrophic lateral sclerosis-like symptoms.
[So] Source:Intern Med;54(9):1105-7, 2015.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We herein report a case of Human T-lymphotropic virus type-I (HTLV-I)-associated myelopathy with bulbar palsy-type amyotrophic lateral sclerosis-like symptoms. A 52-year-old woman developed dyslalia at approximately 40 years of age, which slowly progressed. She presented with muscular atrophy and increased tendon reflexes of the extremities as well as bulbar palsy, from which motor neuron disease was suspected. Cerebrospinal fluid (CSF) testing revealed no abnormalities except for an elevated neopterin concentration at 143.17 pmol/mL (normal ≤30 pmol/mL). Her serum and CSF anti-HTLV-I antibody titers were also high. Intravenous infusions of methylprednisolone decreased the CSF neopterin concentration to 50.33 pmol/mL. Subsequent oral prednisolone therapy was effective in alleviating the symptoms.
[Mh] Termos MeSH primário: Esclerose Amiotrófica Lateral/imunologia
Anti-Inflamatórios/administração & dosagem
Paralisia Bulbar Progressiva/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Atrofia Muscular/imunologia
Paraparesia Espástica Tropical/imunologia
Prednisolona/administração & dosagem
[Mh] Termos MeSH secundário: Esclerose Amiotrófica Lateral/complicações
Biomarcadores/sangue
Paralisia Bulbar Progressiva/tratamento farmacológico
Paralisia Bulbar Progressiva/fisiopatologia
Feminino
Anticorpos Anti-HTLV-I/sangue
Vírus 1 Linfotrópico T Humano/efeitos dos fármacos
Seres Humanos
Meia-Idade
Atrofia Muscular/fisiopatologia
Paraparesia Espástica Tropical/tratamento farmacológico
Paraparesia Espástica Tropical/fisiopatologia
Reflexo Anormal
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (HTLV-I Antibodies); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150507
[Lr] Data última revisão:
150507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150508
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.54.3660



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