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  1 / 1358 MEDLINE  
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[PMID]:26493031
[Au] Autor:Maier P; Heinzelmann S; Böhringer D; Reinhard T
[Ad] Endereço:Eye Centre, University Hospital Freibur, Germany.
[Ti] Título:Prolonged organ culture reduces the incidence of endothelial immune reactions.
[So] Source:Eye (Lond);30(1):127-32, 2016 Jan.
[Is] ISSN:1476-5454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE The number of antigen-presenting cells decreases during organ culture of corneoscleral discs. This might result in a decrease of immune reactions with increasing duration of organ culture. To investigate this hypothesis, we performed a retrospective analysis of all penetrating keratoplasties that were consecutively performed over the last 5 years.PATIENTS AND METHODS All cases of penetrating keratoplasties (n=1006) were divided into two groups, with the division made at the median of the storage time (21 days). These two groups were compared by a Cox proportional hazards survival model regarding the incidence of endothelial immune reactions, clear graft survival, and chronic endothelial cell loss following penetrating keratoplasty considering patient's age, donor's age, and risk situation as co-variates.RESULTS We observed statistically significantly fewer endothelial immune reactions (20.1% (95% confidence interval 15.5-24.5%) after 2 years) in the group with a storage time of more than 21 days compared with the group with a storage time of <21 days (26.5% (95% confidence interval 21.6-31.2%) after 2 years). However, the duration of organ culture did not have a statistically significant effect on clear graft survival or chronic endothelial cell loss.CONCLUSION Our results demonstrate that an increased duration of organ culture leads to a lower incidence of endothelial immune reactions following penetrating keratoplasty. However, we do not recommend increased storage times in general as overall graft survival did not improve. The reason for this apparent paradox may be that the endothelial cell count decreases during storage time.
[Mh] Termos MeSH primário: Células Apresentadoras de Antígenos/imunologia
Epitélio Posterior/imunologia
Ceratoplastia Penetrante
[Mh] Termos MeSH secundário: Adulto
Idoso
Perda de Células Endoteliais da Córnea/patologia
Criopreservação/métodos
Sobrevivência de Enxerto/fisiologia
Seres Humanos
Incidência
Meia-Idade
Técnicas de Cultura de Órgãos
Preservação de Órgãos/métodos
Precipitinas/sangue
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Fatores de Tempo
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Precipitins)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170101
[Lr] Data última revisão:
170101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151024
[St] Status:MEDLINE
[do] DOI:10.1038/eye.2015.207


  2 / 1358 MEDLINE  
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[PMID]:25474508
[Au] Autor:Pajaro A; Nikoloutsopoulos T; Roberts-Thomson P
[Ad] Endereço:1Department of Allergy and Clinical Immunology, Flinders Medical Centre 2SA Pathology, Flinders Medical Centre, Adelaide, SA, Australia.
[Ti] Título:Diagnostic utility of unidentified precipitin lines (UPLs) in immune precipitation assays.
[So] Source:Pathology;47(1):62-7, 2015 Jan.
[Is] ISSN:1465-3931
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Unidentified precipitin lines (UPLs) are lines in immune precipitin assays which do not characterise with known extractable nuclear antigen (ENA) antibodies. Currently, the clinical significance of UPLs is uncertain.The aim of this study was to determine the clinical and laboratory correlates of UPLs detected over a 3 year period in a regional immunopathology laboratory.A total of 144 patients with UPLs on ENA testing were retrospectively analysed.ENA by counterimmunoelectrophoresis (CIE) was performed on 11,869 patient samples with further characterisation being performed for 1437 positive results. Ten percent of the positive ENAs demonstrated UPLs. The majority of patients with UPLs were female (71%) with an average age of 60 years. Precipitin lines for both continuously growing myeloid cell line K562 and rabbit thymus extract (RTE) were more frequent (47%), compared to K562 only (41%) or RTE only (12%). The most common antinuclear antibody (ANA) patterns associated with UPLs were speckled (29%), homogenous (16%), mixed patterns (14%), with 30% negative ANA and 5% showing cytoplasmic patterns (Golgi, GWB, mitochondrial). Both ANA positive and ANA negative patients with UPLs were generally associated with connective tissue and autoimmune disease with the majority demonstrating a positive association of UPLs with Ro52 and/or Ro60/SSA detected by Euroimmun line immunoassay. UPLs frequently seen with a negative ANA were also identified in renal disease, pulmonary fibrosis/bronchiectasis and malignancy/lymphoma.UPLs have uncertain diagnostic utility at this stage and further work needs to be done to clarify this question. UPLs were found in systemic and organ specific autoimmune disease, renal, pulmonary and neoplastic disorders. UPLs can occur in both ANA positive and ANA negative sera. The nature of the precipitating antigen in UPLs is still obscure.
[Mh] Termos MeSH primário: Anticorpos Antinucleares/análise
Antígenos Nucleares/imunologia
Doenças do Tecido Conjuntivo/diagnóstico
Imunoprecipitação
Precipitinas
[Mh] Termos MeSH secundário: Doenças Autoimunes/diagnóstico
Doenças do Tecido Conjuntivo/imunologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Antigens, Nuclear); 0 (Precipitins)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141205
[St] Status:MEDLINE
[do] DOI:10.1097/PAT.0000000000000189


  3 / 1358 MEDLINE  
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[PMID]:24488131
[Au] Autor:Hos D; Heindl LM; Bucher F; Cursiefen C
[Ad] Endereço:Department of Ophthalmology, University of Cologne, Cologne, Germany.
[Ti] Título:Evidence of donor corneal endothelial cell migration from immune reactions occurring after descemet membrane endothelial keratoplasty.
[So] Source:Cornea;33(4):331-4, 2014 Apr.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The migratory capacity of donor corneal endothelial cells after Descemet membrane endothelial keratoplasty (DMEK) is not fully understood. We report 2 patients who developed immune reactions after DMEK with endothelial precipitates detectable not only on the grafts but also on host corneal areas stripped off the host Descemet membrane during surgery and initially not covered by the donor Descemet membrane and endothelium ("naked stroma"), strongly suggesting that migration of donor-derived endothelial cells had occurred. METHODS: Observational case series of 2 patients. RESULTS: A 71-year-old man (case 1) and an 84-year-old man (case 2) with Fuchs endothelial dystrophy underwent successful DMEK surgery. Postoperatively, the peripheral corneal stroma showed a denuded area that was not covered by the DMEK graft or by the patients' residual Descemet membrane (because of large descemetorhexis and slight graft decentration). After 18 (case 1) and 6 (case 2) months, a diffuse endothelial immune reaction with precipitates on the graft and, surprisingly, also on peripheral corneal areas that were initially denuded of the host Descemet membrane and not covered by the donor Descemet membrane was observed. The outermost corneal parts covered by the patients' own residual Descemet membrane showed no precipitates. Under treatment with topical corticosteroids, the precipitates rapidly disappeared. Visual acuity, central corneal thickness, and endothelial cell counts were not significantly affected. CONCLUSIONS: The immune reaction episodes in our patients with endothelial precipitates detectable on adjacent host areas initially stripped off and not covered by donor Descemet membrane provide direct in vivo evidence of donor corneal endothelial cell migration after DMEK, filling areas of "naked stroma."
[Mh] Termos MeSH primário: Movimento Celular/fisiologia
Ceratoplastia Endotelial com Remoção da Lâmina Limitante Posterior
Epitélio Posterior/fisiologia
Distrofia Endotelial de Fuchs/cirurgia
Precipitinas
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Contagem de Células
Glucocorticoides/uso terapêutico
Seres Humanos
Implante de Lente Intraocular
Masculino
Facoemulsificação
Prednisolona/análogos & derivados
Prednisolona/uso terapêutico
Doadores de Tecidos
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Precipitins); 8B2807733D (prednisolone acetate); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140204
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000000054


  4 / 1358 MEDLINE  
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[PMID]:22547734
[Au] Autor:Godet C; Meurice JC; Roblot F; Kauffmann-Lacroix C; Verdaguer M; Frat JP; Cadranel J
[Ti] Título:Efficacy of nebulised liposomal amphotericin B in the attack and maintenance treatment of ABPA.
[So] Source:Eur Respir J;39(5):1261-3, 2012 May.
[Is] ISSN:1399-3003
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Anfotericina B/administração & dosagem
Antifúngicos/administração & dosagem
Aspergilose Broncopulmonar Alérgica/tratamento farmacológico
Nebulizadores e Vaporizadores
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Idoso
Aspergilose Broncopulmonar Alérgica/diagnóstico
Aspergilose Broncopulmonar Alérgica/diagnóstico por imagem
Aspergilose Broncopulmonar Alérgica/imunologia
Eosinófilos/efeitos dos fármacos
Feminino
Seres Humanos
Imunoglobulina E/sangue
Itraconazol/uso terapêutico
Lipossomos
Precipitinas/sangue
Radiografia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Antifungal Agents); 0 (Liposomes); 0 (Precipitins); 304NUG5GF4 (Itraconazole); 37341-29-0 (Immunoglobulin E); 7XU7A7DROE (Amphotericin B)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120502
[St] Status:MEDLINE
[do] DOI:10.1183/09031936.00162311


  5 / 1358 MEDLINE  
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[PMID]:22329454
[Au] Autor:Ampere A; Delhaes L; Soots J; Bart F; Wallaert B
[Ad] Endereço:Service de Pneumologie, Centre Hospitalier Béthune, Lille, France.
[Ti] Título:Hypersensitivity pneumonitis induced by Shiitake mushroom spores.
[So] Source:Med Mycol;50(6):654-7, 2012 Aug.
[Is] ISSN:1460-2709
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hypersensitivity pneumonitis (HP) is a pulmonary granulomatosis involving an immunoallergic mechanism caused by chronic inhalation of antigens, most frequently organic substances, as well as chemicals. We report the first European case of hypersensitivity pneumonitis due to the inhalation of Shiitake mushroom spores. A 37-year-old French Caucasian man with a one-month history of persistent dry cough, shortness of breath and loss of weight was admitted to our hospital on December 2010. Anamnesis showed he was involved in mushroom production beginning in the summer of 2010. His temperature on admission was 36.6°C and he had a normal blood pressure (135/90 mmHg). Bilateral fine crackles were audible in the base of both lungs. Pulmonary function tests showed a mild restrictive pattern with decreased DLco and a PaO(2) of 65 mmHg, Chest CT scan revealed reticulo-nodular shadows, slight ground glass opacities, liner atelectasis, and subpleural opacities in both lung fields. Bronchoscopy was normal but cytological examination of BAL revealed a predominant lymphocytosis (55%). Serum precipitins to the Shiitake mushroom spores were positive (3 precipitins arcs with high intensity) and as a result we advised the patient to cease his mushroom production activities. The diagnosis of hypersensitivity pneumonitis due to inhalation of Shiitake mushroom spores was established as a result of the improvement of all of his clinical symptoms, i.e., cough, weight loss, bilateral fine crackles, mild restrictive pattern of pulmonary function, and reticulo-nodular shadows on chest CT, once exposure was eliminated. Recent interest in exotic mushrooms varieties, e.g., Shiitake, in developed countries because of their possible medicinal properties might increase the potential risk of HP among mushrooms workers. Therefore, healthcare professionals have to take this new potential respiratory disease into account.
[Mh] Termos MeSH primário: Alveolite Alérgica Extrínseca/microbiologia
Exposição por Inalação/efeitos adversos
Cogumelos Shiitake/imunologia
Esporos Fúngicos/imunologia
[Mh] Termos MeSH secundário: Adulto
Alveolite Alérgica Extrínseca/imunologia
Antígenos de Fungos/efeitos adversos
Antígenos de Fungos/imunologia
Líquido da Lavagem Broncoalveolar/imunologia
Broncoscopia
Seres Humanos
Pulmão/microbiologia
Pulmão/patologia
Linfocitose/imunologia
Linfocitose/microbiologia
Masculino
Doenças Profissionais/imunologia
Doenças Profissionais/microbiologia
Testes de Precipitina
Precipitinas/sangue
Testes de Função Respiratória
Tórax/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Fungal); 0 (Precipitins)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120215
[St] Status:MEDLINE
[do] DOI:10.3109/13693786.2012.658091


  6 / 1358 MEDLINE  
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[PMID]:21676373
[Au] Autor:Chee SP; Jap A
[Ad] Endereço:Singapore National Eye Centre, Singapore; National University Health System, Singapore; Singapore Eye Research Institute, Singapore. Electronic address: chee.soon.phaik@snec.com.sg.
[Ti] Título:Immune ring formation associated with cytomegalovirus endotheliitis.
[So] Source:Am J Ophthalmol;152(3):449-453.e1, 2011 Sep.
[Is] ISSN:1879-1891
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe immune ring (IR) formation as a manifestation of cytomegalovirus (CMV) endotheliitis. DESIGN: Retrospective observational case series. METHODS: Review of all consecutive CMV anterior uveitis and endotheliitis patients seen at the Singapore National Eye Centre for the occurrence of an IR. CMV infection was diagnosed by polymerase chain reaction analysis of the aqueous. RESULTS: None of the 72 eyes with CMV anterior uveitis had an IR formation. Four episodes of IR formation were seen in 3 eyes (14.3%) of 21 cases of CMV-positive endotheliitis. All were unilateral and all 3 patients were human immunodeficiency virus negative middle-aged Chinese males. The IR developed 2 to 7 months after occurrence of the endotheliitis and the aqueous was positive for CMV during 2 of the episodes of IR formation. In 2 eyes, the IR occurred at the completion of a course of systemic ganciclovir when the aqueous was negative for CMV. The immune rings resolved with combination therapy of topical prednisolone acetate 0.12% and ganciclovir. Patient 1 had a recurrence of the IR 4 months after stopping treatment but again resolved following treatment with ganciclovir and topical corticosteroids. CONCLUSION: Corneal immune rings can occur as a result of CMV infection. Hence CMV infection may have to be considered in such cases.
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/diagnóstico
Epitélio Posterior/imunologia
Infecções Oculares Virais/diagnóstico
Uveíte Anterior/diagnóstico
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Antivirais/administração & dosagem
Antivirais/uso terapêutico
Humor Aquoso/virologia
Citomegalovirus/genética
Citomegalovirus/isolamento & purificação
Infecções por Citomegalovirus/tratamento farmacológico
Infecções por Citomegalovirus/imunologia
DNA Viral/análise
Quimioterapia Combinada
Infecções Oculares Virais/tratamento farmacológico
Infecções Oculares Virais/imunologia
Feminino
Ganciclovir/administração & dosagem
Ganciclovir/uso terapêutico
Glucocorticoides/administração & dosagem
Glucocorticoides/uso terapêutico
Soronegatividade para HIV
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Precipitinas/imunologia
Prednisolona/administração & dosagem
Prednisolona/análogos & derivados
Prednisolona/uso terapêutico
Estudos Retrospectivos
Resultado do Tratamento
Uveíte Anterior/tratamento farmacológico
Uveíte Anterior/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (DNA, Viral); 0 (Glucocorticoids); 0 (Precipitins); 8B2807733D (prednisolone acetate); 9PHQ9Y1OLM (Prednisolone); P9G3CKZ4P5 (Ganciclovir)
[Em] Mês de entrada:1110
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:110617
[St] Status:MEDLINE


  7 / 1358 MEDLINE  
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[PMID]:20693254
[Au] Autor:Tillie-Leblond I; Grenouillet F; Reboux G; Roussel S; Chouraki B; Lorthois C; Dalphin JC; Wallaert B; Millon L
[Ad] Endereço:Dept of Pneumology, University of Lille, Lille, France. I-Tillie@chru-lille.fr
[Ti] Título:Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria.
[So] Source:Eur Respir J;37(3):640-7, 2011 Mar.
[Is] ISSN:1399-3003
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Metalworking fluids (MWF) are responsible for hypersensitivity pneumonitis (HP). The aim of the present study was to identify the antigen (Ag) responsible for MWF-associated HP, and to optimise serological diagnosis by definition of a threshold allowing discrimination between HP patients and asymptomatic exposed workers. 13 patients, who were workers at a car engine manufacturing plant, were suspected of MWF-associated HP. Microbial analysis of 83 used MWFs was carried out. Sera from 13 MWF-associated HP patients, 12 asymptomatic exposed workers and 18 healthy unexposed controls were tested to determine their immunological responses to three Ags, including Mycobacterium immunogenum. M. immunogenum was identified in 40% of used fluids by culture and confirmed by DNA sequencing. The threshold for differentiating MWF-associated HP patients from asymptomatic exposed workers was five arcs of precipitation (sensitivity 77% and specificity 92%), as determined by electrosyneresis (ES). Using ELISA methods with protein extract from M. immunogenum, a threshold leading to 92% sensitivity and 100% specificity was established. The detection of specific antibodies against M. immunogenum Ag at high levels in case sera suggests that M. immunogenum-contaminated MWF is responsible for MWF-associated HP. To discriminate MWF-associated HP patients from asymptomatic exposed workers, we suggest a five-arc threshold for ES and a 1.6-AU threshold for ELISA methods.
[Mh] Termos MeSH primário: Alveolite Alérgica Extrínseca/microbiologia
Óleos Industriais/microbiologia
Mycobacterium/metabolismo
Doenças Profissionais/microbiologia
[Mh] Termos MeSH secundário: Adulto
Alveolite Alérgica Extrínseca/patologia
Celulose/análogos & derivados
Celulose/química
Ensaio de Imunoadsorção Enzimática/métodos
Seres Humanos
Hipersensibilidade
Masculino
Metalurgia
Meia-Idade
Doenças Profissionais/diagnóstico
Exposição Ocupacional
Precipitinas/química
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Precipitins); 3J2P07GVB6 (acetylcellulose); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100810
[St] Status:MEDLINE
[do] DOI:10.1183/09031936.00195009


  8 / 1358 MEDLINE  
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[PMID]:20805703
[Au] Autor:Bang HI; Yoo JY; Kim KH; Park R; Shin JW; Choi TY; Lee SC; Park HS; Won JH
[Ad] Endereço:Department of Laboratory Medicine, Soonchunhyang University Hospital, Seoul, Korea.
[Ti] Título:[A case of central nervous system myelomatosis with complex chromosome aberrations].
[So] Source:Korean J Lab Med;30(4):334-8, 2010 Aug.
[Is] ISSN:1598-6535
[Cp] País de publicação:Korea (South)
[La] Idioma:kor
[Ab] Resumo:Involvement of the central nervous system is very uncommon in multiple myeloma, observed in approximately 1% of the multiple myeloma patients. We report a case of central nervous system myelomatosis with complex chromosome aberrations in a 62-yr-old female patient, who had previously been diagnosed as multiple myeloma. Fluorescent in situ hybridization revealed 13q deletion, p53 gene deletion and IGH/FGFR3 rearrangement and chromosomal study showed complex chromosome aberrations. After four cycles of chemotherapy, the patient was admitted to the hematology department with severe headache. Plasma cells were found in the cerebrospinal fluid (CSF), and CSF immunoelectrophoresis revealed abnormal precipitin arcs against anti-IgG and anti-lambda antisera. She was given systemic chemotherapy and eight courses of intrathecal chemotherapy, which cleared plasma cells in the CSF. Two months later, she was given autologous stem cell transplantation. Three months after stem cell transplantation, central nervous system myelomatosis progressed to plasma cell leukemia and two months later, the patient expired.
[Mh] Termos MeSH primário: Neoplasias do Sistema Nervoso Central/diagnóstico
Deleção Cromossômica
Mieloma Múltiplo/diagnóstico
Translocação Genética
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Neoplasias do Sistema Nervoso Central/tratamento farmacológico
Neoplasias do Sistema Nervoso Central/genética
Líquido Cefalorraquidiano/citologia
Terapia Combinada
Progressão da Doença
Feminino
Deleção de Genes
Seres Humanos
Imunoeletroforese
Hibridização in Situ Fluorescente
Leucemia Plasmocitária/diagnóstico
Meia-Idade
Mieloma Múltiplo/tratamento farmacológico
Mieloma Múltiplo/genética
Plasmócitos/patologia
Precipitinas/metabolismo
Receptor Tipo 3 de Fator de Crescimento de Fibroblastos/genética
Transplante de Células-Tronco
Transplante Autólogo
Proteína Supressora de Tumor p53/genética
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Precipitins); 0 (Tumor Suppressor Protein p53); EC 2.7.10.1 (FGFR3 protein, human); EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 3)
[Em] Mês de entrada:1011
[Cu] Atualização por classe:140530
[Lr] Data última revisão:
140530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100901
[St] Status:MEDLINE
[do] DOI:10.3343/kjlm.2010.30.4.334


  9 / 1358 MEDLINE  
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[PMID]:20631331
[Au] Autor:Fricker-Hidalgo H; Coltey B; Llerena C; Renversez JC; Grillot R; Pin I; Pelloux H; Pinel C
[Ad] Endereço:Parasitologie-Mycologie, Pôle Biologie, Centre Hospitalier Universitaire, Grenoble Cedex 9, France. Hfricker-hidalgo@chu-grenoble.fr
[Ti] Título:Recombinant allergens combined with biological markers in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients.
[So] Source:Clin Vaccine Immunol;17(9):1330-6, 2010 Sep.
[Is] ISSN:1556-679X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Allergic bronchopulmonary aspergillosis (ABPA) is a frequent complication in cystic fibrosis patients. The diagnosis remains difficult and requires a combination of clinical, radiological, biological, and mycological criteria. The aim of this study was to analyze the added value of two recombinant antigens, rAspf4 and rAspf6, associated with the detection of specific IgG; precipitins; total IgE; and Aspergillus fumigatus in sputum for the diagnosis of ABPA. In a retrospective study, we determined the specific IgE responses to these recombinants in 133 sera of 65 cystic fibrosis patients. We selected an average of five serum samples from each of the 17 patients with ABPA (13 proven and 4 probable ABPA) and from 3 patients with Aspergillus bronchitis and rhinosinusitis. One serum sample for the 45 patients without ABPA was tested. The sensitivity of specific IgE detection against rAspf4 calculated per patient (92.3%) was significantly higher (P < 0.05) than that of rAspf6 (53.8%). When rAspf4 IgE detection was associated with anti-Aspergillus IgG enzyme-linked immunosorbent assay (ELISA) and precipitin detection, the sensitivity rose to 100%. The specificities of rAspf4 and rAspf6 IgE detection were 93.7% and 91.6%, respectively. Other diagnostic criteria had slightly lower specificities (87.5% for anti-Aspergillus IgG ELISA, 89.6% for precipitins, 84.4% for total IgE, and 85.0% for positive A. fumigatus culture in sputum). In conclusion, this retrospective study showed the relevance of rAspf4 IgE detection, in combination with other biological markers (Aspergillus IgG ELISA, precipitins, and total IgE), for improving the biological diagnosis of ABPA.
[Mh] Termos MeSH primário: Alérgenos
Aspergilose Broncopulmonar Alérgica/diagnóstico
Biomarcadores
Fibrose Cística/complicações
Micologia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticorpos Antifúngicos/sangue
Aspergillus fumigatus/isolamento & purificação
Criança
Pré-Escolar
Ensaio de Imunoadsorção Enzimática/métodos
Feminino
Seres Humanos
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Lactente
Masculino
Meia-Idade
Precipitinas/sangue
Proteínas Recombinantes
Estudos Retrospectivos
Sensibilidade e Especificidade
Escarro/microbiologia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antibodies, Fungal); 0 (Biomarkers); 0 (Immunoglobulin G); 0 (Precipitins); 0 (Recombinant Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100716
[St] Status:MEDLINE
[do] DOI:10.1128/CVI.00200-10


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[PMID]:20100013
[Au] Autor:Madani Y; Barlow A; Taher F
[Ad] Endereço:Department of Respiratory Medicine, Watford General Hospital, Watford, Hertfordshire, WD18 0HB, United Kingdom. yasser.madani@doctors.org.uk
[Ti] Título:Severe asthma with fungal sensitization: a case report and review of literature.
[So] Source:J Asthma;47(1):2-6, 2010 Feb.
[Is] ISSN:1532-4303
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is a substantial body of evidence supporting an association between asthma severity and fungal exposure and sensitization. Fungal allergens are a recognized risk factor for severe asthma. We describe the case of a 44-year-old asthmatic whose asthma control deteriorated after moving to a new flat with walls covered in mould. Allergic bronchopulmonary aspergillosis was excluded. Although sensitization to Candida was demonstrated by a positive Candida-specific radioallergosorbent test, the patient did not entirely satisfy the criteria for a diagnosis of allergic bronchopulmonary candidiasis. The patient's asthma control improved after engaging in a monthly washing regimen of the walls. This case further demonstrates the association between fungal sensitization and asthma severity. The term severe asthma with fungal sensitization has been recently coined to describe this phenomenon.
[Mh] Termos MeSH primário: Asma/imunologia
Asma/fisiopatologia
Fungos/imunologia
[Mh] Termos MeSH secundário: Adulto
Poluição do Ar em Ambientes Fechados/efeitos adversos
Asma/diagnóstico por imagem
Asma/terapia
Candida albicans/imunologia
Feminino
Seres Humanos
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Precipitinas/sangue
Precipitinas/imunologia
Radiografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Precipitins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1002
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100127
[St] Status:MEDLINE
[do] DOI:10.3109/02770900903362684



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