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[PMID]:28902942
[Au] Autor:Chen Y; Zeng Y; Zhang Y
[Ad] Endereço:Master of Medicine, Department of Pulmonary Medicine, The Second Affiliated Hospital, Fujian Medical University, China. Acquisition and analysis of data, conception of the study, manuscript writing, final approved.
[Ti] Título:A study on reducing the absorption of lidocaine from the airway in cats.
[So] Source:Acta Cir Bras;32(8):662-672, 2017 Aug.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Purpose: : To determine if the combination of lidocaine with epinephrine or gamma globulin would decrease the rate or reduce the amount of local absorption of lidocaine through the airway. Methods:: Twenty adult male cats were randomly and evenly distributed into four groups: 1) Group LG: lidocaine administered with gamma globulin; 2) Group LS: lidocaine administered with physiological saline); 3) Group LE: lidocaine administered with epinephrine; 4) Group C: control group. Invasive blood pressure, heart rate, and concentration of lidocaine were recorded before and after administration. Results: : The peak of plasma concentrations appeared difference (Group LG: 1.39 ± 0.23 mg/L; Group LS: 1.47 ± 0.29 mg/L and Group LE: 0.99 ± 0.08 mg/L). Compared to Group C, there were significant differences in the average heart rate of Groups LG, LS, and LE (P < 0.05). The average systolic blood pressures were significantly different when each group was compared to Group C (P < 0.05). The biological half-life, AUC0-120, peak time, and half-life of absorption among the three groups have not presented statistically significant differences (P > 0.05). Conclusion:: Administering lidocaine in combination with gamma globulin through airway causes significant decrease the rate and reduce the amount of local absorption of lidocaine in cats.
[Mh] Termos MeSH primário: Agonistas Adrenérgicos beta/farmacocinética
Anestésicos Locais/farmacocinética
Epinefrina/farmacocinética
Lidocaína/farmacocinética
Absorção pelo Trato Respiratório/efeitos dos fármacos
gama-Globulinas/farmacocinética
[Mh] Termos MeSH secundário: Agonistas Adrenérgicos beta/administração & dosagem
Anestésicos Locais/administração & dosagem
Anestésicos Locais/sangue
Animais
Pressão Sanguínea/efeitos dos fármacos
Broncoscopia/métodos
Gatos
Combinação de Medicamentos
Epinefrina/administração & dosagem
Frequência Cardíaca/efeitos dos fármacos
Lidocaína/administração & dosagem
Lidocaína/sangue
Masculino
Distribuição Aleatória
Valores de Referência
Reprodutibilidade dos Testes
Fatores de Tempo
Traqueia/efeitos dos fármacos
gama-Globulinas/administração & dosagem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-Agonists); 0 (Anesthetics, Local); 0 (Drug Combinations); 0 (gamma-Globulins); 98PI200987 (Lidocaine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE


  2 / 15154 MEDLINE  
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[PMID]:28351295
[Au] Autor:Nagyová V; Arfuso F; Rizzo M; Nagy O; Piccione G
[Ad] Endereço:Clinic for Ruminants, University of Veterinary Medicine and Pharmacy in Kosice, Slovak Republic (Nagyová, Nagy).
[Ti] Título:Stability of ovine serum protein fractions under different storage conditions.
[So] Source:J Vet Diagn Invest;29(3):312-315, 2017 May.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We evaluated the effect of different storage conditions on the concentration of serum total proteins and their electrophoretic fractions in sheep. Blood samples were collected from 12 female Comisana sheep, and each serum obtained was divided into 4 aliquots. The first aliquot was analyzed immediately after separation (T0); the second was refrigerated at 4°C and analyzed after 24 h (T1), 48 h (T2), and 72 h (T3); the third was stored at -20°C immediately after centrifugation and analyzed after 2 days (T4); and the last aliquot was stored at -20°C after 24-h refrigeration and analyzed after 1 wk (T5). The concentrations of serum total proteins and their electrophoretic fractions (albumin, α-, ß1-, ß2-, and γ-globulins) was determined. A statistically significant ( p < 0.05) effect of storage conditions on all serum electrophoretic protein fractions and on the albumin-to-globulin (A/G) ratio was found. The values of albumin, α-globulins, and A/G ratio increased at T4 with respect to T0. The levels of α-globulins were higher at T1 than T0; the ß1-globulins levels changed at T3, whereas the ß2- and γ-globulins values as well as the A/G ratio changed at T2 and T3. At T4, we found an increase in the serum concentrations of albumin, α -globulins, and on the A/G ratio, and a decrease of γ fraction. At T5, the concentration of α-globulins was higher than at T0. Hence, we recommend electrophoretic analysis of fresh ovine serum samples or of samples refrigerated for no more than 24 h to obtain accurate data.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/análise
Albumina Sérica/análise
Soroglobulinas/análise
Ovinos/sangue
gama-Globulinas/análise
[Mh] Termos MeSH secundário: Animais
Análise Química do Sangue/veterinária
Estabilidade de Medicamentos
Eletroforese em Gel de Ágar/veterinária
Feminino
Albumina Sérica Humana
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Serum Albumin); 0 (Serum Globulins); 0 (gamma-Globulins); 6D53G0FD0Z (plasma protein fraction); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1177/1040638717700220


  3 / 15154 MEDLINE  
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[PMID]:27838204
[Au] Autor:Liu P; Chen D; Wang Y; Tang X; Li H; Shi J; Tong B; Dong Y
[Ad] Endereço:School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, PR China.
[Ti] Título:A highly sensitive "turn-on" fluorescent probe with an aggregation-induced emission characteristic for quantitative detection of γ-globulin.
[So] Source:Biosens Bioelectron;92:536-541, 2017 Jun 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As a novel "turn on" fluorescent probe, 4-((1Z,3Z)-1,4-bis(4-(methoxycarbonyl)phenyl)-4-(pyridin-4-yl)buta-1,3-dien-1-yl)-1-methylpyridin-1-ium hexafluorophosphate (TABD-Py-PF ) with an aggregation-induced emission characteristic was synthesized for in-situ quantitation of γ-globulins in the blood serum. It was shown that the TABD-Py-PF probe was highly specific for γ-globulins and that other components in the blood serum, including serum albumins, fibrinogen, glucose, urea, and cholesterol, barely interfered with the molecular interactions between TABD-Py-PF and γ-globulins. The high specificity of this probe enabled in-situ quantitative detection of γ-globulins without isolation of γ-globulins from the blood serum. The fluorescence intensity of TABD-Py-PF was linearly correlated with the concentration of γ-globulins in the ranges of 7.89-300µg/mL. The detection limit of γ-globulins was determined to be 7.89µg/mL. The fluorescence response time of TABD-Py-PF for detecting γ-globulins was very short (below 5s), allowing for real-time detection. The mechanism of the fluorescent turn-on behavior of the TABD-Py-PF probe was investigated and electrostatic interactions between TABD-Py-PF and γ-globulins were identified.
[Mh] Termos MeSH primário: Corantes Fluorescentes/química
Compostos de Piridínio/química
Espectrometria de Fluorescência/métodos
gama-Globulinas/análise
[Mh] Termos MeSH secundário: Técnicas Biossensoriais/métodos
Seres Humanos
Limite de Detecção
Modelos Moleculares
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); 0 (Pyridinium Compounds); 0 (gamma-Globulins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161114
[St] Status:MEDLINE


  4 / 15154 MEDLINE  
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[PMID]:27981316
[Au] Autor:Pagnini C; Menasci F; Desideri F; Sanna A; Corleto VD; Delle Fave G
[Ad] Endereço:Digestive and Liver Disease Department, Sant' Andrea Hospital, Sapienza University of Rome, Italy. cristiano.pagnini@uniroma1.it.
[Ti] Título:Searching for biomarkers in clinical practice: the prevalence and clinical significance of hypergammaglobulinemia in inflammatory bowel disease patients.
[So] Source:J Gastrointestin Liver Dis;25(4):565-566, 2016 Dec.
[Is] ISSN:1842-1121
[Cp] País de publicação:Romania
[La] Idioma:eng
[Mh] Termos MeSH primário: Colite Ulcerativa/epidemiologia
Doença de Crohn/epidemiologia
Hipergamaglobulinemia/sangue
Hipergamaglobulinemia/epidemiologia
gama-Globulinas/análise
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Colite Ulcerativa/diagnóstico
Doença de Crohn/diagnóstico
Estudos Transversais
Seres Humanos
Hipergamaglobulinemia/diagnóstico
Prevalência
Estudos Retrospectivos
Fatores de Risco
Cidade de Roma/epidemiologia
Estudos Soroepidemiológicos
Testes Sorológicos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Biomarkers); 0 (gamma-Globulins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.15403/jgld.2014.1121.254.gni


  5 / 15154 MEDLINE  
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[PMID]:27974124
[Au] Autor:Ma XY; Li Z; Wang XJ; Ye JJ; Ma YP; Li Y
[Ad] Endereço:Department of Pediatric Neurology, Women's and Children's Hospital of Qinghai, Xining 810000, China. mxyhzu@126.com.
[Ti] Título:[Clinical efficacy of different doses of gamma globulin combined with glucocorticoid in treatment of moderate/severe acute Guillain-Barré syndrome in children: a comparative analysis].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;18(12):1286-1290, 2016 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the clinical efficacy and safety of intravenous injection of low-dose versus high-dose gamma globulin combined with glucocorticoid pulse therapy in the treatment of children with moderate/severe acute Guillain-Barré syndrome (GBS). METHODS: A total of 100 children with moderate/severe acute GBS were randomly assigned to low-dose group (n=48) and high-dose group (n=52). The children in the low-dose and high-dose groups were treated with 0.2 g/(kg · d) and 0.4 g/(kg · d) gamma globulin respectively combined with methylprednisolone. The two groups were compared in terms of the time to improvements of symptoms after treatment, serum levels of inflammatory factors, proportion of children undergoing invasive ventilation, treatment response rate, and adverse events. RESULTS: After 5 days of treatment, the low- and high-dose groups had significant reductions in serum levels of tumor necrosis factor-α, interleukin-6, and C-reactive protein, and there were no significant differences in the reductions of these markers between the two groups. There were no significant differences between the two groups in the time to recovery of respiratory muscle paralysis, time to an improvement in muscle strength of one grade, time to recovery of sensory disturbance, and length of hospital stay. There was no significant difference in the treatment response rate between the low- and high-dose groups (90% vs 92%). There were also no significant differences in the incidence rates of pyrexia, headache, nausea, and palpitation between the two groups. CONCLUSIONS: Low-dose versus high-dose gamma globulin combined with methylprednisolone pulse therapy have comparable clinical efficacy and safety in the treatment of children with moderate/severe acute GBS.
[Mh] Termos MeSH primário: Síndrome de Guillain-Barré/tratamento farmacológico
Metilprednisolona/administração & dosagem
gama-Globulinas/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Proteína C-Reativa/análise
Criança
Pré-Escolar
Feminino
Seres Humanos
Tempo de Internação
Masculino
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha); 0 (gamma-Globulins); 9007-41-4 (C-Reactive Protein); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE


  6 / 15154 MEDLINE  
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[PMID]:27889733
[Au] Autor:Sato T; Somura J; Maruo Y
[Ad] Endereço:Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan. Correspondence to: Dr Tomomi Sato, Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan. ttflutedr@yahoo.co.jp.
[Ti] Título:Steroid Pulse Therapy for Kawasaki Disease Complicated with Myocarditis.
[So] Source:Indian Pediatr;53(11):1015-1016, 2016 Nov 15.
[Is] ISSN:0974-7559
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The clinical management of intravenous immunoglobulin-resistant Kawasaki disease shock syndrome (KDSS) is obscure. CASE CHARACTERISTICS: Three children presented with intravenous immunoglobulin-resistant KDSS complicated with myocarditis. OUTCOME: All cases were successfully managed with steroid pulse therapy. MESSAGE: Steroid pulse therapy is effective in immunoglobulin-resistant KDSS.
[Mh] Termos MeSH primário: Síndrome de Linfonodos Mucocutâneos
Miocardite
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Pré-Escolar
Seres Humanos
Masculino
Pulsoterapia
gama-Globulinas
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (gamma-Globulins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


  7 / 15154 MEDLINE  
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[PMID]:27751217
[Au] Autor:Xia LP; Chen X; Jiang Y
[Ad] Endereço:Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China. jiangyiwd@163.com.
[Ti] Título:[Clinical effect of gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura in children].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;18(10):988-990, 2016 Oct.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the clinical effect of high-dose gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura (HSP). METHODS: Thirty-three children with abdominal HSP were randomly assigned to dexamethasone group (15 children) and gamma globulin group (18 children). The children in the dexamethasone group were treated with dexamethasone and conventional treatment, and those in the gamma globulin group were treated with high-dose gamma globulin pulse therapy in addition to the conventional treatment. Clinical outcome and recurrence rate were observed in both groups. RESULTS: Compared with the dexamethasone group, the gamma globulin group had a significantly shorter onset time of rash, a significantly shorter time to complete regression of rash, a significantly shorter time to abdominal pain remission, and a significantly shorter time to disappearance of bloody stool, as well as comparable time to vomiting remission and length of hospital stay. The gamma globulin group had a significantly higher response rate than the dexamethasone group (95% vs 65%; P<0.05) and a significantly lower recurrence rate within 6 months than the dexamethasone group (5.6% vs 33.3%; P<0.05). CONCLUSIONS: High-dose gamma globulin pulse therapy has a marked clinical effect in the treatment of abdominal HSP. It is safe and reliable and has a low recurrence rate, and therefore, it holds promise for clinical application.
[Mh] Termos MeSH primário: Púrpura de Schoenlein-Henoch/tratamento farmacológico
gama-Globulinas/administração & dosagem
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Dexametasona/efeitos adversos
Dexametasona/uso terapêutico
Feminino
Seres Humanos
Masculino
Recidiva
gama-Globulinas/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (gamma-Globulins); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


  8 / 15154 MEDLINE  
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[PMID]:27651276
[Au] Autor:Sekar G; Florance I; Sivakumar A; Mukherjee A; Chandrasekaran N
[Ad] Endereço:Centre for Nanobiotechnology, VIT University, Vellore 632014, Tamil Nadu, India.
[Ti] Título:Role of PAMAM-OH dendrimers against the fibrillation pathway of biomolecules.
[So] Source:Int J Biol Macromol;93(Pt A):1007-1018, 2016 Dec.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The binding behavior of nanoparticle with proteins determines its biocompatibility. This study reports the interaction of ten different biomolecules (proteins-BSA, HSA, haemoglobin, gamma globulin, transferrin and enzymes-hog and bacillus amylase, lysozyme from chicken and human and laccases from Tramates versicolor) with a surface group hydroxylated Poly AMido AMide dendrimer (PAMAM) of generation 5. The study has utilized various spectroscopic methods like UV-vis spectroscopy, Fluorescence emission, Synchronous, 3-D spectroscopy and Circular Dichroism to detect the binding induced structural changes in biomolecules that occur upon interaction with mounting concentration of the dendrimers. Aggregation of proteins results in the formation of amyloid fibrils causing several human diseases. In this study, fibrillar samples of all ten biomolecules formed in the absence and the presence of dendrimers were investigated with Congo Red absorbance and ThT Assay to detect fibril formation, Trp Emission and 3-D scan to evaluate the effect of fibrillation on aromatic environment of biomolecules, and CD spectroscopy to measure the conformational changes in a quantitative manner. These assays have generated useful information on the role of dendrimers in amyloid fibril formation of biomolecules. The outcomes of the study remain valuable in evaluating the biological safety of PAMAM-OH dendrimers for their biomedical application in vivo.
[Mh] Termos MeSH primário: Amiloide/química
Dendrímeros/química
[Mh] Termos MeSH secundário: Animais
Proteínas Aviárias/química
Bacillus subtilis/enzimologia
Proteínas de Bactérias/química
Basidiomycota/enzimologia
Bovinos
Galinhas
Etanol/química
Proteínas Fúngicas/química
Seres Humanos
Lacase/química
Muramidase/química
Agregados Proteicos
Ligação Proteica
Albumina Sérica/química
Suínos
Transferrina/química
alfa-Amilases/química
gama-Globulinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid); 0 (Avian Proteins); 0 (Bacterial Proteins); 0 (Dendrimers); 0 (Fungal Proteins); 0 (PAMAM Starburst); 0 (Protein Aggregates); 0 (Serum Albumin); 0 (Transferrin); 0 (gamma-Globulins); 3K9958V90M (Ethanol); EC 1.10.3.2 (Laccase); EC 3.2.1.1 (alpha-Amylases); EC 3.2.1.17 (Muramidase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160922
[St] Status:MEDLINE


  9 / 15154 MEDLINE  
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[PMID]:27499487
[Au] Autor:Lantos J
[Ti] Título:Henry K. Beecher and the Oversight of Research in Children.
[So] Source:Perspect Biol Med;59(1):95-106, 2016.
[Is] ISSN:1529-8795
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Henry K. Beecher was a pioneer of research ethics and a prominent whistleblower with regard to ethically problematic studies. Most of his work focused on research in adults, not children, but he did speculate about the implications of his ethical concerns for research in minors. This paper reviews Beecher's response to Krugman's studies of hepatitis at the Willowbrook State School and the debate that Beecher's article stimulated between Ramsey and McCormick. That debate shaped the terms that were used in current federal regulations for research in children. The paper then speculates about whether Beecher would have approved of our current regulatory system.
[Mh] Termos MeSH primário: Pesquisa Biomédica/ética
Ensaios Clínicos como Assunto/ética
Pediatria/ética
[Mh] Termos MeSH secundário: Pesquisa Biomédica/legislação & jurisprudência
Criança
Ensaios Clínicos como Assunto/legislação & jurisprudência
Crianças com Deficiência
Hepatite/prevenção & controle
Experimentação Humana/ética
Seres Humanos
Consentimento Livre e Esclarecido/ética
Pediatria/legislação & jurisprudência
Pesquisadores/ética
Vacinas contra Hepatite Viral/administração & dosagem
Vacinas contra Hepatite Viral/efeitos adversos
gama-Globulinas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Hepatitis Vaccines); 0 (gamma-Globulins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE
[do] DOI:10.1353/pbm.2016.0017


  10 / 15154 MEDLINE  
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[PMID]:27401913
[Au] Autor:Yang L; Wu EY; Tarrant TK
[Ad] Endereço:Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.
[Ti] Título:Immune Gamma Globulin Therapeutic Indications in Immune Deficiency and Autoimmunity.
[So] Source:Curr Allergy Asthma Rep;16(8):55, 2016 Jul.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Immune gamma globulin (IgG) has a long history in the treatment of both primary immune deficiency and autoimmune disorders. Disease indications continue to expand and new-generation products increase the versatility of delivery. This review encompasses a historical perspective as well as current and future implications of human immune globulin for the treatment of immune-mediated illness.
[Mh] Termos MeSH primário: Autoimunidade/imunologia
Síndromes de Imunodeficiência/tratamento farmacológico
gama-Globulinas/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Síndromes de Imunodeficiência/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (gamma-Globulins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-016-0632-7



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