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[PMID]:29178648
[Au] Autor:Riera M; Wert A; Nieto I; Pomares E
[Ad] Endereço:Departament de Genètica, Institut de Microcirurgia Ocular (IMO), Barcelona, Spain.
[Ti] Título:Panel-based whole exome sequencing identifies novel mutations in microphthalmia and anophthalmia patients showing complex Mendelian inheritance patterns.
[So] Source:Mol Genet Genomic Med;5(6):709-719, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Microphthalmia and anophthalmia (MA) are congenital eye abnormalities that show an extremely high clinical and genetic complexity. In this study, we evaluated the implementation of whole exome sequencing (WES) for the genetic analysis of MA patients. This approach was used to investigate three unrelated families in which previous single-gene analyses failed to identify the molecular cause. METHODS: A total of 47 genes previously associated with nonsyndromic MA were included in our panel. WES was performed in one affected patient from each family using the AmpliSeq Exome technology and the Ion Proton platform. RESULTS: A novel heterozygous OTX2 missense mutation was identified in a patient showing bilateral anophthalmia who inherited the variant from a parent who was a carrier, but showed no sign of the condition. We also describe a new PAX6 missense variant in an autosomal-dominant pedigree affected by mild bilateral microphthalmia showing high intrafamiliar variability, with germline mosaicism determined to be the most plausible molecular cause of the disease. Finally, a heterozygous missense mutation in RBP4 was found to be responsible in an isolated case of bilateral complex microphthalmia. CONCLUSION: This study highlights that panel-based WES is a reliable and effective strategy for the genetic diagnosis of MA. Furthermore, using this technique, the mutational spectrum of these diseases was broadened, with novel variants identified in each of the OTX2, PAX6, and RBP4 genes. Moreover, we report new cases of reduced penetrance, mosaicism, and variable phenotypic expressivity associated with MA, further demonstrating the heterogeneity of such disorders.
[Mh] Termos MeSH primário: Anoftalmia/genética
Microftalmia/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Anoftalmia/diagnóstico
Sequência de Bases
Análise Mutacional de DNA
Heterozigoto
Seres Humanos
Padrões de Herança
Microftalmia/diagnóstico
Mosaicismo
Mutação de Sentido Incorreto
Fatores de Transcrição Otx/genética
Fator de Transcrição PAX6/genética
Linhagem
Polimorfismo de Nucleotídeo Único
Proteínas Plasmáticas de Ligação ao Retinol/genética
Alinhamento de Sequência
Sequenciamento Completo do Exoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (OTX2 protein, human); 0 (Otx Transcription Factors); 0 (PAX6 Transcription Factor); 0 (PAX6 protein, human); 0 (RBP4 protein, human); 0 (Retinol-Binding Proteins, Plasma)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.329


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[PMID]:28964327
[Au] Autor:Nevalainen J; Korpimaki T; Kouru H; Sairanen M; Ryynanen M
[Ad] Endereço:Department of Obstetrics and Gynecology, Oulu University Hospital, Finland. Electronic address: marttjaa@paju.oulu.fi.
[Ti] Título:Performance of first trimester biochemical markers and mean arterial pressure in prediction of early-onset pre-eclampsia.
[So] Source:Metabolism;75:6-15, 2017 Oct.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To develop a predictive risk model for early-onset pre-eclampsia (EO-PE) using maternal characteristics, combined screening markers, previously reported biomarkers for PE and mean arterial pressure (MAP). METHODS: This retrospective study was conducted at Oulu University hospital between 2006 and 2010. Maternal serum from first trimester combined screening was further analyzed for alpha fetoprotein (AFP), placental growth factor (PlGF), soluble tumor necrosis factor receptor-1 (sTNFR1), retinol binding protein-4 (RBP4), a disintegrin and metalloprotease-12 (ADAM12), soluble P-selectin (sP-selectin), follistatin like-3 (FSTL3), adiponectin, angiopoietin-2 (Ang-2) and sex hormone binding globulin (SHBG). First, the training sample set with 29 cases of EO-PE and 652 controls was developed to study whether these biomarkers separately or in combination with prior risk (maternal characteristics, first trimester pregnancy associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotrophin (fß-hCG)) could be used to predict the development of EO-PE. Second, the developed risk models were validated with a test sample set of 42 EO-PE and 141 control subjects. For the test set MAP data was also available. RESULTS: Single marker statistically significant (ANOVA p<0.05) changes between control and EO-PE pregnancies were observed with AFP, RBP4 and sTNFR1 with both training and test sample sets. Based on the test sample set performances, the best detection rate, 47% for a 10% false positive rate, was achieved with PlGF and sTNFR1 added with prior risk and MAP. CONCLUSION: Based on our results, the best first trimester biomarkers to predict the subsequent EO-PE were AFP, PlGF, RBP4 and sTNFR1. The risk models that performed best for the prediction of EO-PE included prior risk, MAP, sTNFR1 and AFP or PlGF or RBP4.
[Mh] Termos MeSH primário: Pressão Arterial/fisiologia
Pré-Eclâmpsia/diagnóstico
Valor Preditivo dos Testes
Primeiro Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Estudos de Casos e Controles
Diagnóstico Precoce
Feminino
Seres Humanos
Proteínas de Membrana/sangue
Pré-Eclâmpsia/sangue
Gravidez
Receptores Tipo I de Fatores de Necrose Tumoral/sangue
Proteínas Plasmáticas de Ligação ao Retinol/análise
Estudos Retrospectivos
alfa-Fetoproteínas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AFP protein, human); 0 (Biomarkers); 0 (Membrane Proteins); 0 (PIGF protein, human); 0 (RBP4 protein, human); 0 (Receptors, Tumor Necrosis Factor, Type I); 0 (Retinol-Binding Proteins, Plasma); 0 (alpha-Fetoproteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


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[PMID]:28813718
[Au] Autor:Du M; Phelps E; Balangue MJ; Dockins A; Moiseyev G; Shin Y; Kane S; Otalora L; Ma JX; Farjo R; Farjo KM
[Ad] Endereço:Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
[Ti] Título:Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4375­4383, 2017 08 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Transgenic mice overexpressing serum retinol-binding protein (RBP4-Tg) develop progressive retinal degeneration, characterized by microglia activation, yet the precise mechanisms underlying retinal degeneration are unclear. Previous studies showed RBP4-Tg mice have normal ocular retinoid levels, suggesting that degeneration is independent of the retinoid visual cycle or light exposure. The present study addresses whether retinal degeneration is light-dependent and RBP4-dependent by testing the effects of dark-rearing and pharmacological lowering of serum RBP4 levels, respectively. Methods: RBP4-Tg mice reared on normal mouse chow in normal cyclic light conditions were directly compared to RBP4-Tg mice exposed to chow supplemented with the RBP4-lowering compound A1120 or dark-rearing conditions. Quantitative retinal histological analysis was conducted to assess retinal degeneration, and electroretinography (ERG) and optokinetic tracking (OKT) tests were performed to assess retinal and visual function. Ocular retinoids and bis-retinoid A2E were quantified. Results: Dark-rearing RBP4-Tg mice effectively reduced ocular bis-retinoid A2E levels, but had no significant effect on retinal degeneration or dysfunction in RBP4-Tg mice, demonstrating that retinal degeneration is light-independent. A1120 treatment lowered serum RBP4 levels similar to wild-type mice, and prevented structural retinal degeneration. However, A1120 treatment did not prevent retinal dysfunction in RBP4-Tg mice. Moreover, RBP4-Tg mice on A1120 diet had significant worsening of OKT response and loss of cone photoreceptors compared to RBP4-Tg mice on normal chow. This may be related to the very significant reduction in retinyl ester levels in the retina of mice on A1120-supplemented diet. Conclusions: Retinal degeneration in RBP4-Tg mice is RBP4-dependent and light-independent.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica/fisiologia
Lesões Experimentais por Radiação/genética
Retina/efeitos da radiação
Degeneração Retiniana/genética
Proteínas Plasmáticas de Ligação ao Retinol/genética
[Mh] Termos MeSH secundário: Animais
Adaptação à Escuridão
Eletrorretinografia
Feminino
Luz
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Piperidinas/farmacologia
Lesões Experimentais por Radiação/metabolismo
Lesões Experimentais por Radiação/patologia
Degeneração Retiniana/metabolismo
Degeneração Retiniana/patologia
Retinoides/metabolismo
Proteínas Plasmáticas de Ligação ao Retinol/antagonistas & inibidores
Proteínas Plasmáticas de Ligação ao Retinol/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (A1120 agent); 0 (Piperidines); 0 (Rbp4 protein, mouse); 0 (Retinoids); 0 (Retinol-Binding Proteins, Plasma)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22107


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[PMID]:28734946
[Au] Autor:Malechka VV; Moiseyev G; Takahashi Y; Shin Y; Ma JX
[Ad] Endereço:Department of Physiology, Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
[Ti] Título:Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy.
[So] Source:Am J Pathol;187(10):2222-2231, 2017 Oct.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diabetic retinopathy is a common complication of diabetes mellitus. Diabetic patients experience functional deficits in dark adaptation, contrast sensitivity, and color perception before microvascular pathologies become apparent. Herein, we evaluated early changes in neural retinal function and in retinoid metabolism in the eye in diabetes. Streptozotocin-induced diabetic rats showed decreased a- and b-wave amplitudes of scotopic and photopic electroretinography responses 4 months after diabetes induction compared to nondiabetic controls. Although Western blot analysis revealed no difference in opsin expression, rhodopsin content was decreased in diabetic retinas, as shown by a difference in absorbance. Consistently, levels of 11-cis-retinal, the chromophore for visual pigments, were significantly lower in diabetic retinas compared to those in controls, suggesting a retinoid deficiency. Among visual cycle proteins, interphotoreceptor retinoid-binding protein and stimulated by retinoic acid 6 protein showed significantly lower levels in diabetic rats than those in nondiabetic controls. Similarly, serum levels of retinol-binding protein 4 and retinoids were significantly lower in diabetic rats. Overall, these results suggest that retinoid metabolism in the eye is impaired in type 1 diabetes, which leads to deficient generation of visual pigments and neural retinal dysfunction in early diabetes.
[Mh] Termos MeSH primário: Retinopatia Diabética/metabolismo
Retinopatia Diabética/patologia
Rodopsina/metabolismo
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/patologia
Retinopatia Diabética/sangue
Retinopatia Diabética/complicações
Modelos Animais de Doenças
Masculino
Células Fotorreceptoras de Vertebrados/metabolismo
Células Fotorreceptoras de Vertebrados/patologia
Ratos Wistar
Retina/patologia
Retina/fisiopatologia
Retinaldeído/metabolismo
Proteínas Plasmáticas de Ligação ao Retinol/metabolismo
Vias Visuais/metabolismo
Vias Visuais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Rbp4 protein, rat); 0 (Retinol-Binding Proteins, Plasma); 9009-81-8 (Rhodopsin); RR725D715M (Retinaldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


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[PMID]:28668878
[Au] Autor:Sobotka R; Capoun O; Kalousová M; Hanus T; Zima T; Kostírová M; Soukup V
[Ad] Endereço:Department of Urology, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
[Ti] Título:Prognostic Importance of Vitamins A, E and Retinol-binding Protein 4 in Renal Cell Carcinoma Patients.
[So] Source:Anticancer Res;37(7):3801-3806, 2017 07.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:AIM: To assess the prognostic importance of serum levels of retinol, retinol-binding protein 4 (RBP4) and vitamin E at the time of diagnosis in patients with renal cell carcinoma (RCC). PATIENTS AND METHODS: In this prospective study, in a cohort of 102 renal cell carcinoma patients, relationships between serum levels of the aforementioned markers and recurrence-free survival (RFS), overall survival (OS), as well as cancer-specific survival (CSS), were evaluated. The vitamin A and vitamin E levels were determined by high-performance liquid chromatography (HPLC), while the RBP4 level by enzyme-linked immunosorbent assay (ELISA). RESULTS: The median follow-up period was 39 months. Renal cell carcinoma recurred in 9 patients; 23 patients died with 12 of them from RCC. The preoperative vitamin E level was associated to RFS (p=0.02). We found a significant relationship between OS and the level of RBP4 (p=0.002), retinol (p=0.037) and vitamin E (p=0.007). The CSS period was significantly associated with the level of RBP4 (p=0.0001) and retinol (p=0.0003). Patients with an RBP4 level less than 21.0 mg/l at the time of diagnosis had a 13.5-times higher risk of death due to RCC progression; this risk was up to 7.7-times higher with vitamin A levels under 0.52 mg/l. CONCLUSION: Low levels of vitamin A, E and RBP4 at the time of RCC diagnosis are associated with a poorer prognosis after surgery.
[Mh] Termos MeSH primário: Carcinoma de Células Renais/sangue
Neoplasias Renais/sangue
Proteínas Plasmáticas de Ligação ao Retinol/análise
Vitamina A/sangue
Vitamina E/sangue
Vitaminas/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma de Células Renais/diagnóstico por imagem
Carcinoma de Células Renais/cirurgia
Feminino
Seres Humanos
Neoplasias Renais/diagnóstico por imagem
Neoplasias Renais/cirurgia
Masculino
Meia-Idade
Nefrectomia
Período Pré-Operatório
Prognóstico
Análise de Sobrevida
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RBP4 protein, human); 0 (Retinol-Binding Proteins, Plasma); 0 (Vitamins); 11103-57-4 (Vitamin A); 1406-18-4 (Vitamin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


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[PMID]:28625041
[Au] Autor:Taslim NA; Virani D; Sumartini NK; Karmila; Bukhari A; Aminuddin; As'ad S; Satriono R; Rasyid H; Djaharuddin I
[Ad] Endereço:Department of Nutrition Faculty of Medicine, Universitas Hasanuddin, Makassar Indonesia. Email: pudji_taslim@yahoo.com.
[Ti] Título:Energy regulation in newly diagnosed TB with chronic energy deficiency: free fatty acids and RBP4.
[So] Source:Asia Pac J Clin Nutr;26(Suppl 1):S73-S78, 2017 Jun.
[Is] ISSN:0964-7058
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Energy metabolism may be dysfunctionally integral between host and infective agent in active tuberculosis, mediated by adipocytokines and free fatty acids (FFA) as the products of triglyceride lipolysis in fat, blood or other tissues. Retinol Binding Protein 4 (RBP4) and asymmetric dimethylarginine (ADMA) are candidate adipocytokines. The possibility of a deleterious metabolic nexus in chronic energy deficiency (CED) (BMI <18.5 kg/m2) is explored. METHODS AND DESIGN: Newly diagnosed patients with tuberculosis (n=63) were selected using consecutive random sampling at a Centre for the Care and Treatment of Lung Diseases in Makassar, Indonesia. Diagnosis of pulmonary TB required microscopy with Ziehl-Neelsen stain. Anthropometric measurements were taken. Venesection allowed glomerular filtration rate, FFA, serum glutamic oxaloacetic transaminase and glutamate-pyruvate transaminase to be assessed. RESULTS: CED was evident in 60.3%. For the well and lesser nourished, medians were, respectively, FFA 0.30 and 0.37 mmol/mL (p=0.960); RBP4 199730 ng/mL and 11721 ng/mL (p=0.009); GFR 106 ml/min and 113 ml/min (p=0.673); and ADMA 0.52 ng/mL and 0.51 ng/mL (p=0.172). BMI and serum RBP4 were correlated (ρ=0.52, p<0.001), with odds ratios (OR) 5.8 (CI 1.68-20.3). RBP4 in CED was lower than in better nourished patients. Serum FFA is not evidently associated with BMI in patients with active TB. CONCLUSIONS: RBP4 is some 6-fold lower when active TB patients have CED than when BMI >25 kg/m2. However, FFA was not associated with CED in these active TB patients which may be a type 2 error or represent an energy impasse where infection and the host's metabolic needs are in competition.
[Mh] Termos MeSH primário: Metabolismo Energético/fisiologia
Ácidos Graxos não Esterificados/metabolismo
Desnutrição/metabolismo
Proteínas Plasmáticas de Ligação ao Retinol/metabolismo
Tuberculose/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Arginina/análogos & derivados
Arginina/metabolismo
Índice de Massa Corporal
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Proteínas Plasmáticas de Ligação ao Retinol/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Nonesterified); 0 (RBP4 protein, human); 0 (Retinol-Binding Proteins, Plasma); 63CV1GEK3Y (N,N-dimethylarginine); 94ZLA3W45F (Arginine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.6133/apjcn.062017.s9


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[PMID]:28621339
[Au] Autor:Meex RCR; Watt MJ
[Ad] Endereço:Monash Biomedicine Discovery Institute, Metabolic Disease and Obesity Program and the Department of Physiology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
[Ti] Título:Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance.
[So] Source:Nat Rev Endocrinol;13(9):509-520, 2017 Sep.
[Is] ISSN:1759-5037
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver disease and is present in up to ∼70% of individuals who are overweight. NAFLD is also associated with hypertriglyceridaemia and low levels of HDL, glucose intolerance, insulin resistance and type 2 diabetes mellitus. Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle. Hepatokines are proteins that are secreted by hepatocytes, and many hepatokines have been linked to the induction of metabolic dysfunction, including fetuin A, fetuin B, retinol-binding protein 4 (RBP4) and selenoprotein P. In this Review, we describe the factors that influence the development of hepatic steatosis, provide evidence of strong links between hepatic steatosis and insulin resistance in non-hepatic tissues, and discuss recent advances in our understanding of how steatosis alters hepatokine secretion to influence metabolic phenotypes through inter-organ communication.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/fisiologia
Resistência à Insulina
Fígado/fisiopatologia
Hepatopatia Gordurosa não Alcoólica/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Tipo 2
Dieta Hiperlipídica
Fetuína-B/fisiologia
Seres Humanos
Hipertrigliceridemia
Metabolismo dos Lipídeos/fisiologia
Obesidade
Sobrepeso
Proteínas Plasmáticas de Ligação ao Retinol/fisiologia
Selenoproteína P/fisiologia
alfa-2-Glicoproteína-HS/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Fetuin-B); 0 (RBP4 protein, human); 0 (Retinol-Binding Proteins, Plasma); 0 (Selenoprotein P); 0 (alpha-2-HS-Glycoprotein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1038/nrendo.2017.56


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[PMID]:28337595
[Au] Autor:Fruscalzo A; Frommer J; Londero AP; Henze A; Schweigert FJ; Nofer JR; Steinhard J; Klockenbusch W; Schmitz R; Raila J
[Ad] Endereço:Obstetrics and Gynecology, St. Franziskus-Hospital of Ahlen, Robert-Koch-Straße 55, 59227, Ahlen, Germany. fruscal@libero.it.
[Ti] Título:First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome.
[So] Source:Arch Gynecol Obstet;295(5):1157-1165, 2017 May.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). METHODS: Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight <10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37). RESULTS: We found decreased RBP4 in SGA patients that delivered fetuses <3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05). CONCLUSIONS: First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.
[Mh] Termos MeSH primário: Recém-Nascido Pequeno para a Idade Gestacional/sangue
Pré-Albumina/análise
Proteínas Plasmáticas de Ligação ao Retinol/análise
Vitamina A/sangue
[Mh] Termos MeSH secundário: Peso ao Nascer
Estudos de Casos e Controles
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Fator de Crescimento Placentário/sangue
Pré-Eclâmpsia/sangue
Gravidez
Primeiro Trimestre da Gravidez/sangue
Receptor 1 de Fatores de Crescimento do Endotélio Vascular/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Prealbumin); 0 (RBP4 protein, human); 0 (Retinol-Binding Proteins, Plasma); 11103-57-4 (Vitamin A); 144589-93-5 (Placenta Growth Factor); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-017-4338-4


  9 / 1233 MEDLINE  
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[PMID]:28329079
[Au] Autor:Li L; Fu J; Yu XT; Li G; Xu L; Yin J; Cheng H; Hou D; Zhao X; Gao S; Li W; Li C; Grant SFA; Li M; Xiao Y; Mi J; Li M
[Ad] Endereço:Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
[Ti] Título:Sleep Duration and Cardiometabolic Risk Among Chinese School-aged Children: Do Adipokines Play a Mediating Role?
[So] Source:Sleep;40(5), 2017 May 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study Objectives: To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children and to explore the possible mediating role of adipokines. Methods: Sleep duration was collected in 3166 children from the Beijing Child and Adolescent Metabolic Syndrome study. Glucose homeostasis and other cardiometabolic risk factors were assessed. Serum adipokines including leptin, total and high-molecular-weight (HMW) adiponectin, resistin, fibroblast growth factor 21 (FGF21), and retinol binding protein 4 (RBP4) were determined. Results: Among the 6- to 12-year-old children, after adjusting for covariates including puberty, short sleep duration was associated with increased body mass index (BMI), waist circumference, fasting glucose, insulin and homeostasis model assessment of insulin resistance (all p < .0001), higher triglyceride and lower high-density lipoprotein cholesterol (p < .05), along with increased leptin (p < .0001), FGF21 (p < .05) and decreased HMW-adiponectin (p ≤ .01); the association with leptin remained significant after further adjustment for BMI. However, these associations, except for glucose (p < .0001), disappeared after further adjusted for leptin. For the 13-18 years old group, short sleep duration was associated with higher BMI, waist circumference, and RBP4 (all p < .05), but the association with RBP4 was attenuated after adjusting for BMI (p = .067). Conclusions: Short sleep duration is strongly associated with obesity and hyperglycemia (in 6-12 years old), along with adverse adipokine secretion patterns among Chinese children. The associations with cardiometabolic risk factors appear to be more pronounced in younger children, and could be explained, at least partially, by leptin levels.
[Mh] Termos MeSH primário: Adipocinas/sangue
Adipocinas/metabolismo
Grupo com Ancestrais do Continente Asiático
Doenças Cardiovasculares/metabolismo
Síndrome Metabólica/metabolismo
Sono/fisiologia
[Mh] Termos MeSH secundário: Adipocinas/secreção
Adiponectina/sangue
Adolescente
Glicemia/análise
Índice de Massa Corporal
Doenças Cardiovasculares/sangue
Criança
China/etnologia
HDL-Colesterol/sangue
Feminino
Fatores de Crescimento de Fibroblastos/sangue
Seres Humanos
Hiperglicemia/sangue
Hiperglicemia/metabolismo
Insulina/sangue
Resistência à Insulina
Leptina/sangue
Masculino
Síndrome Metabólica/sangue
Obesidade/sangue
Obesidade/metabolismo
Resistina/sangue
Proteínas Plasmáticas de Ligação ao Retinol/análise
Proteínas Plasmáticas de Ligação ao Retinol/metabolismo
Fatores de Risco
Fatores de Tempo
Triglicerídeos/sangue
Circunferência da Cintura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Adiponectin); 0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Insulin); 0 (Leptin); 0 (RBP4 protein, human); 0 (RETN protein, human); 0 (Resistin); 0 (Retinol-Binding Proteins, Plasma); 0 (Triglycerides); 0 (fibroblast growth factor 21); 62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx042


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[PMID]:28279965
[Au] Autor:Lounder DT; Khandelwal P; Dandoy CE; Jodele S; Grimley MS; Wallace G; Lane A; Taggart C; Teusink-Cross AC; Lake KE; Davies SM
[Ad] Endereço:Division of Bone Marrow Transplant and Immune Deficiency.
[Ti] Título:Lower levels of vitamin A are associated with increased gastrointestinal graft-versus-host disease in children.
[So] Source:Blood;129(20):2801-2807, 2017 May 18.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin A promotes development of mucosal tolerance and enhances differentiation of regulatory T cells. Vitamin A deficiency impairs epithelial integrity, increasing intestinal permeability. We hypothesized that higher vitamin A levels would reduce the risk of graft-versus-host disease (GVHD) through reduced gastrointestinal (GI) permeability, reduced mucosal injury, and reduced lymphocyte homing to the gut. We tested this hypothesis in a cohort study of 114 consecutive patients undergoing allogeneic stem cell transplant. Free vitamin A levels were measured in plasma at day 30 posttransplant. GI GVHD was increased in patients with vitamin A levels below the median (38% vs 12.4% at 100 days, = .0008), as was treatment-related mortality (17.7% vs 7.4% at 1 year, = .03). Bloodstream infections were increased in patients with vitamin A levels below the median (24% vs 8% at 1 year, = .03), supporting our hypothesis of increased intestinal permeability. The GI mucosal intestinal fatty acid-binding protein was decreased after transplant, confirming mucosal injury, but was not correlated with vitamin A levels, indicating that vitamin A did not protect against mucosal injury. Expression of the gut homing receptor CCR9 on T-effector memory cells 30 days after transplant was increased in children with vitamin A levels below the median ( = -0.34, = .03). Taken together, these data support our hypothesis that low levels of vitamin A actively promote GI GVHD and are not simply a marker of poor nutritional status or a sicker patient. Vitamin A supplementation might improve transplant outcomes.
[Mh] Termos MeSH primário: Gastroenteropatias/sangue
Doença Enxerto-Hospedeiro/sangue
Vitamina A/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Demografia
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Transplante de Células-Tronco Hematopoéticas/mortalidade
Seres Humanos
Incidência
Lactente
Mucosa Intestinal/patologia
Análise Multivariada
Permeabilidade
Receptores CCR/metabolismo
Proteínas Plasmáticas de Ligação ao Retinol/metabolismo
Condicionamento Pré-Transplante
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CC chemokine receptor 9); 0 (RBP4 protein, human); 0 (Receptors, CCR); 0 (Retinol-Binding Proteins, Plasma); 11103-57-4 (Vitamin A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1182/blood-2017-02-765826



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