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Pesquisa : D12.776.124.790.720.100.500 [Categoria DeCS]
Referências encontradas : 16 [refinar]
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  1 / 16 MEDLINE  
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[PMID]:29281661
[Au] Autor:Kurz S; Thieme R; Amberg R; Groth M; Jahnke HG; Pieroh P; Horn LC; Kolb M; Huse K; Platzer M; Volke D; Dehghani F; Buzdin A; Engel K; Robitzki A; Hoffmann R; Gockel I; Birkenmeier G
[Ad] Endereço:Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany.
[Ti] Título:The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.
[So] Source:PLoS One;12(12):e0189514, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat's cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.
[Mh] Termos MeSH primário: Neoplasias/prevenção & controle
alfa 2-Macroglobulinas Associadas à Gravidez/fisiologia
[Mh] Termos MeSH secundário: Animais
Xenoenxertos
Seres Humanos
Modelos Animais
Ratos-Toupeira
Neoplasias/patologia
PTEN Fosfo-Hidrolase/metabolismo
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteínas Smad/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (Smad Proteins); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.1.3.67 (PTEN Phosphohydrolase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189514


  2 / 16 MEDLINE  
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[PMID]:23600290
[Au] Autor:Promzeleva NV; Zorina VN; Zorin NA
[Ti] Título:[Macroglobulin family proteins in breast cancer].
[So] Source:Vopr Onkol;58(5):688-90, 2012.
[Is] ISSN:0507-3758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Determined serum levels of alpha-2-macroglobulin (a2-MG) and pregnancy-associate alpha-2-glycoprotein (a2-PAG) in 98 breast cancer patients stage I-IV prior to the special antitumor treatment. Statistically significant negative correlative dependence of the a2-PAG in the blood and lifetime of patients is proved. We believe that the definition of pre-treatment level of a serum a2-MG and a2-PAG concentrations for patients with breast cancer, can be used as an additional predictor of life expectancy.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/sangue
Neoplasias da Mama/sangue
alfa 2-Macroglobulinas Associadas à Gravidez/metabolismo
alfa-Macroglobulinas/metabolismo
[Mh] Termos MeSH secundário: Neoplasias da Mama/patologia
Feminino
Seres Humanos
Expectativa de Vida
Meia-Idade
Estadiamento de Neoplasias
Valor Preditivo dos Testes
Prognóstico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (alpha-Macroglobulins)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130423
[St] Status:MEDLINE


  3 / 16 MEDLINE  
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[PMID]:22946221
[Au] Autor:Botvin'eva IA; Renge LV; Zorina RM; Bazhenova LG; zorina VN
[Ti] Título:[The proteins of fast phase of inflammation in prognosis of condition of newborn in case of pregnancy complicated by hydramnion and under the risk of intrauterine infection].
[So] Source:Klin Lab Diagn;(6):22-5, 2012 Jun.
[Is] ISSN:0869-2084
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The content of alpha-macroglobulin associated with pregnancy, alpha2-glycoprotein, alpha1-antitripsin, and lactolerrin in blood serum of pregnant women and umbilical serum under hydramnion and risk of development of intrauterine infection of fetus is investigated. It is demonstrated that in case ofpresence in blood of pregnant woman of G-antibodies to C. trachomatis under low titers (1:20, 1:40) the increase of levels of alpha-macroglobulin, alpha2-glycoprotein, al-antitripsin and especially of lactoferrin in serum of pregnant women testifies the high risk of presence of intrauterine infection of fetus and probability of birth of child with low values on Apgar scale.
[Mh] Termos MeSH primário: alfa 2-Macroglobulinas Associadas à Gravidez/metabolismo
Útero
alfa 1-Antitripsina/sangue
alfa-Macroglobulinas/metabolismo
[Mh] Termos MeSH secundário: Índice de Apgar
Infecções por Chlamydia/metabolismo
Chlamydia trachomatis/imunologia
Chlamydia trachomatis/isolamento & purificação
Feminino
Seres Humanos
Recém-Nascido
Inflamação/metabolismo
Lactoferrina/sangue
Poli-Hidrâmnios/sangue
Gravidez
Complicações Infecciosas na Gravidez/metabolismo
Prognóstico
Útero/metabolismo
Útero/microbiologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (SERPINA1 protein, human); 0 (alpha 1-Antitrypsin); 0 (alpha-Macroglobulins); EC 3.4.21.- (Lactoferrin)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:120905
[Lr] Data última revisão:
120905
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120906
[St] Status:MEDLINE


  4 / 16 MEDLINE  
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[PMID]:21080484
[Au] Autor:Yeng C; Osman E; Mohamed Z; Noordin R
[Ad] Endereço:Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia.
[Ti] Título:Detection of immunogenic parasite and host-specific proteins in the sera of active and chronic individuals infected with Toxoplasma gondii.
[So] Source:Electrophoresis;31(23-24):3843-9, 2010 Dec.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Toxoplasma gondii infection in pregnant women may result in abortion and foetal abnormalities, and may be life-threatening in immunocompromised hosts. To identify the potential infection markers of this disease, 2-DE and Western blot methods were employed to study the parasite circulating antigens and host-specific proteins in the sera of T. gondii-infected individuals. The comparisons were made between serum protein profiles of infected (n=31) and normal (n=10) subjects. Antigenic proteins were identified by immunoblotting using pooled sera and monoclonal anti-human IgM-HRP. Selected protein spots were characterised using mass spectrometry. Prominent differences were observed when serum samples of T. gondii-infected individuals and normal controls were compared. A significant up-regulation of host-specific proteins, α(2)-HS glycoprotein and α(1)-B glycoprotein, was also observed in the silver-stained gels of both active and chronic infections. However, only α(2)-HS glycoprotein and α(1)-B glycoprotein in the active infection showed immunoreactivity in Western blots. In addition, three spots of T. gondii proteins were detected, namely (i) hypothetical protein chrXII: 3984434-3 TGME 49, (ii) dual specificity protein phosphatase, catalytic domain TGME 49 and (iii) NADPH-cytochrome p450 reductase TGME 49. Thus, 2-DE approach followed by Western blotting has enabled the identification of five potential infection markers for the diagnosis of toxoplasmosis: three are parasite-specific proteins and two are host-specific proteins.
[Mh] Termos MeSH primário: Antígenos de Protozoários/sangue
Proteínas Sanguíneas/análise
Interações Hospedeiro-Parasita
Proteínas de Protozoários/sangue
Toxoplasma/isolamento & purificação
Toxoplasmose/sangue
[Mh] Termos MeSH secundário: Western Blotting
Doença Crônica
Bases de Dados de Proteínas
Eletroforese em Gel Bidimensional
Seres Humanos
Espectrometria de Massas
alfa 2-Macroglobulinas Associadas à Gravidez/análise
Toxoplasma/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (Blood Proteins); 0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (Protozoan Proteins)
[Em] Mês de entrada:1103
[Cu] Atualização por classe:101214
[Lr] Data última revisão:
101214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101117
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201000038


  5 / 16 MEDLINE  
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[PMID]:20723675
[Au] Autor:Thompson IM; Cerri RL; Kim IH; Green JA; Santos JE; Thatcher WW
[Ad] Endereço:Department of Animal Sciences, University of Florida, Gainesville 32611, USA.
[Ti] Título:Effects of resynchronization programs on pregnancy per artificial insemination, progesterone, and pregnancy-associated glycoproteins in plasma of lactating dairy cows.
[So] Source:J Dairy Sci;93(9):4006-18, 2010 Sep.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objectives were to develop a timed artificial insemination (TAI) resynchronization program to improve pregnancy per AI and to evaluate responses of circulating progesterone and pregnancy-associated glycoproteins in lactating cows. Cows (n=1,578) were presynchronized with 2 injections of PGF2alpha, given 14 d apart starting on d 45+/-3 postpartum, followed by Ovsynch [2 injections of GnRH 7 d before and 56 h after injection of PGF2alpha, TAI 16 h after second injection (d 0)]. The Resynch-treated cows received an intravaginal progesterone insert from d 18 to 25, GnRH on d 25, and pregnancy diagnosis on d 32, and nonpregnant cows received PGF2alpha., GnRH 56 h later, and TAI 16 h later (d 35). The control cows were diagnosed for pregnancy on d 32 and nonpregnant cows received GnRH, PGF2alpha 39 d after TAI, GnRH 56 h later, and TAI 16 h later (d 42). Pregnancy was reconfirmed on d 60 after AI. Ovarian structures were examined in a subset of cows at the time of GnRH and PGF2alpha injections. Blood samples for analyses of progesterone and pregnancy-associated glycoproteins were collected every 2 d from d 18 to 30 in 100 cows, and collection continued weekly to d 60 for pregnant cows (n=43). Preenrollment pregnancies per AI on d 32 did not differ for cows subsequently treated as Resynch (45.8%, n=814) and control (45.9%, n=764), and pregnancy losses on d 60 were 6.7 and 4.0%, respectively. Resynchronized service pregnancy per AI (36%, n=441; 39.5%, n=412) and pregnancy losses (6.3 and 6.7%) did not differ for Resynch and control treatments, respectively. Days open for pregnant cows after 2 TAI were less for the Resynch treatment than for the control treatment (96.2+/-0.82 vs. 99.5+/-0.83 d). Cows in the Resynch treatment had more large follicles at the time of GnRH. The number of corpora lutea did not differ between treatments at the time of PGF2alpha. Plasma progesterone for pregnant cows was greater for Resynch cows than for control cows (18-60 d; 6.6 vs. 5.3 ng/mL), and plasma concentrations of progesterone on d 18 were greater for pregnant cows than for nonpregnant cows (5.3 vs. 4.3 ng/mL). Plasma pregnancy-associated glycoproteins during pregnancy were lower for cows in the Resynch treatment compared with control cows on d 39 (2.8 vs. 4.1 ng/mL) and 46 (1.3 vs. 3.0 ng/mL). Cows pregnant on d 32 that lost pregnancy by d 60 (n=7) had lower plasma concentrations of pregnancy-associated glycoproteins on d 30 than cows that maintained pregnancy (n=36; 2.9 vs. 5.0 ng/mL). Pregnancy-associated glycoproteins on d 30 (>0.33 ng/mL) were predictive of a positive d 32 pregnancy diagnosis (sensitivity=100%; specificity=90.6%). In conclusion, Resynch and control protocols had comparable pregnancy per AI for first and second TAI services, but pregnancy occurred 3.2 d earlier in the Resynch group because inseminations in the Resynch treatment began 7 d before those in the control treatment. Administration of an intravaginal progesterone insert, or GnRH, or both increased progesterone during pregnancy. Dynamics of pregnancy-associated glycoproteins were indicative of pregnancy status and pregnancy loss.
[Mh] Termos MeSH primário: Sincronização do Estro/sangue
Inseminação Artificial/veterinária
Lactação/sangue
alfa 2-Macroglobulinas Associadas à Gravidez/análise
Progesterona/sangue
[Mh] Termos MeSH secundário: Animais
Bovinos/sangue
Bovinos/fisiologia
Ensaio de Imunoadsorção Enzimática/veterinária
Sincronização do Estro/métodos
Sincronização do Estro/fisiologia
Feminino
Lactação/fisiologia
Ovário/diagnóstico por imagem
Parto/sangue
Parto/fisiologia
Gravidez
Fatores de Tempo
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pregnancy-Associated alpha 2-Macroglobulins); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1011
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100821
[St] Status:MEDLINE
[do] DOI:10.3168/jds.2009-2941


  6 / 16 MEDLINE  
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[PMID]:19946848
[Au] Autor:Gajewski Z; Pertajitis M; Sousa N; Beckers J; Pawlinski B; Janett F
[Ad] Endereço:Department of Clinical Sciences, Faculty of Veterinary Medicine, WULS, Warsaw, Poland. zgajewski@supermidia.pl
[Ti] Título:Pregnancy - associated glycoproteins as a new diagnostic tool in cattle reproduction.
[So] Source:Schweiz Arch Tierheilkd;151(12):577-82, 2009 Dec.
[Is] ISSN:0036-7281
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Pregnancy-associated glycoproteins (PAGs) are powerful pregnancy markers in domestic cattle. These proteins are expressed in mono- and binucleate trophoblast cells from the first days of gestation until calving. Different molecules were identified as being expressed at various stages of pregnancy. However, up to date, their functions and activities during pregnancy were not yet established. Specific RIA tests were developed (classic and alternative RIA) and used to measure the concentration of these glycoproteins in blood during gestation and the postpartum period in cattle. In maternal blood, PAGs rise to detectable levels from days 24 to 28 after fertilization. A recent study indicated that PAGs can also be detected in milk samples. However, concentrations in milk are much lower when compared to those of plasma.
[Mh] Termos MeSH primário: Prenhez/sangue
alfa 2-Macroglobulinas Associadas à Gravidez/análise
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Fertilização
Gravidez
Radioimunoensaio/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pregnancy-Associated alpha 2-Macroglobulins)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:091130
[Lr] Data última revisão:
091130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091201
[St] Status:MEDLINE
[do] DOI:10.1024/0036-7281.151.12.577


  7 / 16 MEDLINE  
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[PMID]:17802803
[Au] Autor:Zorina VN; Predeina EM; Zorina RM; Levchenko VG; Bazhenova LG; Zorin NA
[Ti] Título:[The level of pregnancy-associated alpha2-glycoprotein and the hormonal background during different options of hormonal replacement therapy in the menopausal syndrome].
[So] Source:Klin Lab Diagn;(7):24-7, 2007 Jul.
[Is] ISSN:0869-2084
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The authors studied the concentration of pregnancy-associated alpha2-glycoprotein (PA alpha2GP), a sensitive marker of estrogen-dependent tumors, and the association of its level with the serum content of a number of hormones: follicle-stimulating hormone, luteinizing hormone, estradiol (E-2), dehydroepiandrosterone sulfate (DEAS-S), and testosterone in females receiving the groups of drugs containing: 1) estradiol valerate; 2) 17beta-estradiol, and 3) tibolone. The type of the active ingredient of a drug and the duration of its administration were shown to differently affect both the concentration of hypothalamopituitary hormones and steroid sex hormones and the level of PA alpha2GP). The latter increased significantly in Group 1 and insignificantly in Group 2 and did not differ from the normal values in Group 3, at the same time the concentration of E-2 elevated in Groups 1 and 2, rather than in Group 3; the level of DEAS-S increased in Groups 2 and 3 irrespective of the duration of use. Moreover, there were elevated levels of testosterone in Group 3 and those of DEAS-S in Group 1 only when the drugs were administered for 3-6 months. A number of correlations were found in the levels of PA alpha2GP with those of steroid hormones. The authors consider that individual monitoring of the level of PA alpha2GP in the females who need hormonal therapy in menopause provides a useful guide to choosing a drug, monitoring its use efficiency, and preventing malignant proliferation in proper time.
[Mh] Termos MeSH primário: Terapia de Reposição de Estrogênios
Hormônios/sangue
Menopausa/sangue
Monitorização Fisiológica
Neoplasias/prevenção & controle
alfa 2-Macroglobulinas Associadas à Gravidez/análise
[Mh] Termos MeSH secundário: Terapia de Reposição de Estrogênios/efeitos adversos
Feminino
Seres Humanos
Meia-Idade
Monitorização Fisiológica/métodos
Neoplasias/sangue
Neoplasias/induzido quimicamente
Síndrome
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones); 0 (Pregnancy-Associated alpha 2-Macroglobulins)
[Em] Mês de entrada:0712
[Cu] Atualização por classe:070906
[Lr] Data última revisão:
070906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070907
[St] Status:MEDLINE


  8 / 16 MEDLINE  
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[PMID]:17639717
[Au] Autor:Zorina VN; Zorin NA; Lykova OF; Konysheva TV; Zorina RM
[Ti] Título:[Alpha-2-macroglobulin ligands and their biotransport mechanisms].
[So] Source:Biomed Khim;53(2):164-71, 2007 Mar-Apr.
[Is] ISSN:2310-6972
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Alpha-2-macroglobulin (MG) is a high-molecular weight glycoprotein that possesses a wide range of regulatory functions. Earlier it has been shown that covalent binding of MG with proteinases results in conformational transformation of MG, which enables MG to transport some additional types of cytokines linked by noncovalent interactions. The results of our study have demonstrated that the range of proteins, with the ability for additional binding with transformed MG is variable and comprises IgG, IgA, IgM, albumin, both types of lipoprotein chain, plasmin, some cytokines and even pregnancy associated alpha-2-glycoprotein (structured MG homolog). The major ligands are found to be albumin, IgG, plasmin and, to a lesser degree, lipoproteins. MG interactions with both acidic and low-alkaline proteinases contribute to neutralization of total charge of the formed complex at neutral pH, typical for internal fluids of the organism, and that the addition of low-density lipoprotein receptor-related protein (LRP) increases the amount of electroneutral complexes at pH 7.4. We suppose, that this mechanism enables the transformed MG (or may be its complex with other regulatory proteins) to rapidly precipitate rapidly on cellular surface and then, after binding with LRP and secondary neutralization of the total charge under physiological pH conditions, to pass through cellular membrane and to realize its own regulatory functions.
[Mh] Termos MeSH primário: Gravidez/sangue
alfa-Macroglobulinas/metabolismo
[Mh] Termos MeSH secundário: Transporte Biológico Ativo/fisiologia
Citocinas/análise
Citocinas/sangue
Feminino
Fibrinolisina/análise
Fibrinolisina/metabolismo
Seres Humanos
Imunoglobulinas/análise
Imunoglobulinas/sangue
Ligantes
Lipoproteínas/análise
Lipoproteínas/sangue
Masculino
alfa 2-Macroglobulinas Associadas à Gravidez/análise
alfa 2-Macroglobulinas Associadas à Gravidez/metabolismo
Ligação Proteica/fisiologia
Albumina Sérica/análise
Albumina Sérica/metabolismo
alfa-Macroglobulinas/análise
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Immunoglobulins); 0 (Ligands); 0 (Lipoproteins); 0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (Serum Albumin); 0 (alpha-Macroglobulins); EC 3.4.21.7 (Fibrinolysin)
[Em] Mês de entrada:0709
[Cu] Atualização por classe:140401
[Lr] Data última revisão:
140401
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070721
[St] Status:MEDLINE


  9 / 16 MEDLINE  
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[PMID]:16523653
[Au] Autor:Zorin NA; Zorina VN; Zorina RM
[Ti] Título:[Role of proteins of the macroglobulin family in regulation of tumor growth].
[So] Source:Ontogenez;37(1):12-9, 2006 Jan-Feb.
[Is] ISSN:0475-1450
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Proteins of the macroglobulin family are an ancient and evolutionarily conservative link of the immune system, which is actively involved in both inhibition of tumor growth cells and proliferation of tumor cells. Two basically different binding sites and a great conformational plasticity of all representatives of the macroglobulin family, as well as the presence of two to four representatives of the family in the blood of most species allow them to transport diverse substances and exert various regulatory influences on both the tumor and the entire organism. For example, the capacity of macroglobulins for binding hydrolases makes it possible to inhibit enzyme mediated tumor invasion. At the same time, an excess of macroglobulin/hydrolase complexes can activate apoptosis. The tumor is able of using macroglobulins, especially pregnancy-associated proteins, for its own protection. Specifically, pregnancy-associated alpha2-glycoprotein, which is actively produced by human tumor cells, blocks the histocompatibility complex antigens. On the contrary, the capacity of binding zinc stimulates the thymulin-dependent activation of natural killer cells. Nevertheless, the actively growing tumor expresses many receptors to macroglobulins, which are the main carriers of some cytokines and growth factors essential for proliferation.
[Mh] Termos MeSH primário: Proliferação Celular
Hidrolases/metabolismo
Complexos Multiproteicos/metabolismo
Neoplasias/metabolismo
alfa 2-Macroglobulinas Associadas à Gravidez/metabolismo
Evasão Tumoral
[Mh] Termos MeSH secundário: Animais
Apoptose/imunologia
Transporte Biológico/imunologia
Evolução Molecular
Feminino
Antígenos de Histocompatibilidade/imunologia
Antígenos de Histocompatibilidade/metabolismo
Seres Humanos
Hidrolases/imunologia
Células Matadoras Naturais/imunologia
Células Matadoras Naturais/metabolismo
Complexos Multiproteicos/imunologia
Metástase Neoplásica
Neoplasias/imunologia
Gravidez
alfa 2-Macroglobulinas Associadas à Gravidez/imunologia
Fator Tímico Circulante/imunologia
Fator Tímico Circulante/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Histocompatibility Antigens); 0 (Multiprotein Complexes); 0 (Pregnancy-Associated alpha 2-Macroglobulins); 9H198D04WL (Thymic Factor, Circulating); EC 3.- (Hydrolases)
[Em] Mês de entrada:0604
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060310
[St] Status:MEDLINE


  10 / 16 MEDLINE  
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[PMID]:11369298
[Au] Autor:Spencer F; Chi L; Zhu M
[Ad] Endereço:Health Research Center, Southern University, 70813, Baton Rouge, LA, USA. fitz@grant.phys.subr.edu
[Ti] Título:Temporal relationships among uterine pituitary adenylate cyclase-activating polypeptide, decidual prolactin-related protein and progesterone receptor mRNAs expressions during decidualization and gestation in rats.
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;129(1):25-34, 2001 May.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pituitary adenylate cyclase-activating peptide (PACAP), a novel compound with vasoactive intestinal polypeptide-like activity, was recently shown to be localized in the neuronal endings of the human uterus. The purpose of the present study was to assess the functional presence of PACAP mRNA in the decidual endometrium and its relationship to the expression levels of decidual prolactin-related protein (dPRP) and the progesterone receptor mRNAs during decidualization and pregnancy in Sprague-Dawley rats. PACAP was constitutively and temporally expressed in the decidual endometrium and gravid uterus. The time-dependent correlated expression levels of PACAP, dPRP and the progesterone receptor were induced by the neurogenic reproductive signals, i.e. the vagino-cervical/deciduogenic stimuli of decidualization and by the normal equivalent stimuli of mating/blastocyst implantation of gestation. Correlation among the mRNA expression levels of PACAP, dPRP and the progesterone receptor and the coordinated inhibitory actions of the anti-progesterone (RU-486) suggest that there is also correlated time-dependent steroid regulation of the mRNA levels of PACAP, dPRP and the progesterone receptor in the decidual and pregnant uteri. One possible functional meaning for the time-related localization of endometrial/uterine PACAP could be to facilitate endometrial blood flow and increase the availability of metabolic substrates to the developing deciduoma or embryo. The study demonstrates the potential importance of PACAP expression in the regulation of the maternal feto-placental component and suggests a prominent reproductive role for the neuropeptide in mammalian pregnancy.
[Mh] Termos MeSH primário: Neurotransmissores/genética
alfa 2-Macroglobulinas Associadas à Gravidez
Prolactina/metabolismo
RNA Mensageiro/metabolismo
Receptores de Progesterona/metabolismo
[Mh] Termos MeSH secundário: Animais
Primers do DNA
Decídua/metabolismo
Endométrio/metabolismo
Feminino
Glicoproteínas/metabolismo
Antagonistas de Hormônios/farmacologia
Masculino
Mifepristona/farmacologia
Neurotransmissores/metabolismo
Gravidez
Proteínas da Gravidez/metabolismo
Prolactina/análogos & derivados
Prolactina/genética
Ratos
Ratos Sprague-Dawley
Receptores de Progesterona/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Transdução de Sinais
Útero/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (DNA Primers); 0 (Dtprp protein, rat); 0 (Glycoproteins); 0 (Hormone Antagonists); 0 (Neurotransmitter Agents); 0 (Pregnancy Proteins); 0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (RNA, Messenger); 0 (Receptors, Progesterone); 0 (decidualization-associated protein, rat); 320T6RNW1F (Mifepristone); 9002-62-4 (Prolactin)
[Em] Mês de entrada:0108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010523
[St] Status:MEDLINE



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