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Pesquisa : D12.776.124.862.575 [Categoria DeCS]
Referências encontradas : 111 [refinar]
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  1 / 111 MEDLINE  
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[PMID]:21037404
[Au] Autor:Blumenthal S
[Ad] Endereço:Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. sblument@uic.edu
[Ti] Título:From insulin and insulin-like activity to the insulin superfamily of growth-promoting peptides: a 20th-century odyssey.
[So] Source:Perspect Biol Med;53(4):491-508, 2010.
[Is] ISSN:1529-8795
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 1941, Gellhorn reported that administration of human blood to hypophysectomized/adrenodemedullated rats caused a fall in blood sugar. This was among the early demonstrations that human blood possesses glucose-lowering or insulin-like activity (ILA). Gellhorn assumed he had detected only insulin. During the 1960s, however, it became evident that plasma ILA contained at least two components: one, suppressible ILA (SILA), was inactivated by anti-insulin antibody and was therefore considered to be indistinguishable from pancreatic insulin; the other, nonsuppressible ILA (NSILA), was unaffected by anti-insulin antibody. Subsequent work resolved NSILA into insulin-like growth factors I and II (IGF-I and IGF-II), two 7.5 kilodalton peptides with potent mitogenic properties; established their identity with the somatomedins; and investigated both their therapeutic potential and role in the pathogenesis of neoplastic and other human diseases. Insulin and the IGFs exhibit striking homologies in amino acid composition and some degree of overlap in their signaling pathways and actions. Moreover, insulin-like proteins have been identified not only in all vertebrate classes but also in molluscs, insects, and worms. These observations are the basis for the hypothesis that the genes encoding vertebrate insulins and IGFs and invertebrate insulin-like molecules evolved from a common ancestral gene, and for the concept of an insulin superfamily of growth-promoting peptides.
[Mh] Termos MeSH primário: Insulina/sangue
Insulina/fisiologia
Atividade Insulin-Like não Suprimível/fisiologia
Somatomedinas/fisiologia
[Mh] Termos MeSH secundário: Animais
Hormônio do Crescimento/sangue
Hormônio do Crescimento/fisiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Insulin); 0 (Nonsuppressible Insulin-Like Activity); 0 (Somatomedins); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1102
[Cu] Atualização por classe:111117
[Lr] Data última revisão:
111117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101102
[St] Status:MEDLINE
[do] DOI:10.1353/pbm.2010.0001


  2 / 111 MEDLINE  
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[PMID]:8339044
[Au] Autor:Oh Y; Müller HL; Neely EK; Lamson G; Rosenfeld RG
[Ad] Endereço:Department of Pediatrics, Stanford University School of Medicine, CA 94305.
[Ti] Título:New concepts in insulin-like growth factor receptor physiology.
[So] Source:Growth Regul;3(2):113-23, 1993 Jun.
[Is] ISSN:0956-523X
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Mh] Termos MeSH primário: Receptores de Somatomedina/fisiologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Divisão Celular
Seres Humanos
Fator de Crescimento Insulin-Like I/metabolismo
Fator de Crescimento Insulin-Like II/metabolismo
Atividade Insulin-Like não Suprimível/farmacologia
Receptores de Somatomedina/classificação
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.; REVIEW
[Nm] Nome de substância:
0 (Nonsuppressible Insulin-Like Activity); 0 (Receptors, Somatomedin); 67763-96-6 (Insulin-Like Growth Factor I); 67763-97-7 (Insulin-Like Growth Factor II)
[Em] Mês de entrada:9309
[Cu] Atualização por classe:071114
[Lr] Data última revisão:
071114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930601
[St] Status:MEDLINE


  3 / 111 MEDLINE  
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[PMID]:1605542
[Au] Autor:Giudicelli R; Paoli-Doucet M; Garbe L; Vialette B; Bordigoni L; Auge A; Fuentes P
[Ad] Endereço:Service de Chirurgie Thoracique et des Maladies de l'Oesophage, Hôpital Sainte-Marguerite, Marseille.
[Ti] Título:[Extrapancreatic hypoglycemic tumors. Apropos of a case of pleural fibrosarcoma].
[Ti] Título:Tumeurs hypoglycémiantes extra-pancréatiques. Etude à propos d'un cas de fibrosarcome pleural..
[So] Source:Ann Chir;46(2):174-6, 1992.
[Is] ISSN:0003-3944
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The authors report a case of pleural fibrosarcoma associated with severe hypoglycaemia. Chromatography of the patient's serum and tumour fragments revealed a substance with a high molecular weight and an insulin-like activity. Professor Poffengarger's laboratory identified this substance as Non Suppressible Insulin-Like Protein or NSILAp which induces insulin-like effects on various tissues. A review of the literature is presented in the light of this case.
[Mh] Termos MeSH primário: Fibrossarcoma/complicações
Hipoglicemia/etiologia
Neoplasias Pleurais/complicações
[Mh] Termos MeSH secundário: Adulto
Fibrossarcoma/sangue
Fibrossarcoma/cirurgia
Seres Humanos
Masculino
Atividade Insulin-Like não Suprimível/análise
Neoplasias Pleurais/sangue
Neoplasias Pleurais/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Nonsuppressible Insulin-Like Activity)
[Em] Mês de entrada:9207
[Cu] Atualização por classe:091111
[Lr] Data última revisão:
091111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:920101
[St] Status:MEDLINE


  4 / 111 MEDLINE  
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[PMID]:2256491
[Au] Autor:Samaan NA; Schultz PN; Pham FK
[Ad] Endereço:Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030.
[Ti] Título:Insulin-like growth factor II and nonsuppressible insulin-like activity levels in newborns.
[So] Source:Am J Obstet Gynecol;163(6 Pt 1):1836-9, 1990 Dec.
[Is] ISSN:0002-9378
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We measured insulin-like growth factor II and nonsuppressible insulin-like activity levels in the sera of newborn infants with different birth weights and gestational ages to determine the significance of these peptides in fetal growth. Our results obtained by use of one-way analysis of variance showed that the insulin-like growth factor II and nonsuppressible insulin-like activity levels in premature, average-weight-for-gestational-age, large-for-gestational-age, and small-for-gestational-age newborns were significantly different (p less than 0.01). Although levels in the premature neonates were less than the other three groups and large-for-gestational-age neonates had a higher insulin-like growth factor II level than the other three groups, maternal insulin-like growth factor II levels in all groups were similar. These results suggest that insulin-like growth factor II may play a major role in fetal growth.
[Mh] Termos MeSH primário: Recém-Nascido/sangue
Fator de Crescimento Insulin-Like II/metabolismo
Atividade Insulin-Like não Suprimível/metabolismo
[Mh] Termos MeSH secundário: Análise de Variância
Peso ao Nascer
Desenvolvimento Embrionário e Fetal
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido Prematuro/sangue
Fator de Crescimento Insulin-Like II/fisiologia
Atividade Insulin-Like não Suprimível/fisiologia
Gravidez
Radioimunoensaio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nonsuppressible Insulin-Like Activity); 67763-97-7 (Insulin-Like Growth Factor II)
[Em] Mês de entrada:9101
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:901201
[St] Status:MEDLINE


  5 / 111 MEDLINE  
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[PMID]:2537194
[Au] Autor:Daughaday WH
[Ad] Endereço:Washington University School of Medicine, St Louis, Missouri.
[Ti] Título:Hypoglycemia in patients with non-islet cell tumors.
[So] Source:Endocrinol Metab Clin North Am;18(1):91-101, 1989 Mar.
[Is] ISSN:0889-8529
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Persistent hypoglycemia occasionally is associated with tumors of many types. Usually these tumors are of large size and often are of mesenchymal origin. There is evidence of increased glucose uptake from the blood, some of which may occur in the tumor itself. In addition, hepatic glucose production may also be impaired. While increased levels of insulin have never been unequivocally established in the plasma of these patients, a number of insulin-like peptides have been reported. One such peptide may be related to insulin-like growth factor II, but reports from different laboratories are conflicting. Recently, the possible role of oncogenes in stimulating tumor glucose metabolism and tissue necrosis factor and other cytokines in stimulating general glucose uptake have received attention. Treatment of the condition includes surgery, radiation, or chemotherapy directed at the primary tumor and supportive measures with increased glucose administration and corticosteroids.
[Mh] Termos MeSH primário: Hipoglicemia/etiologia
[Mh] Termos MeSH secundário: Adenoma de Células das Ilhotas Pancreáticas
Idoso
Criança
Gluconeogênese
Glucose/metabolismo
Seres Humanos
Hipoglicemia/metabolismo
Insulina/biossíntese
Fígado/metabolismo
Mesenquimoma/complicações
Mesenquimoma/metabolismo
Atividade Insulin-Like não Suprimível/biossíntese
Transtornos Nutricionais/metabolismo
Neoplasias Pancreáticas
Somatomedinas/biossíntese
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Insulin); 0 (Nonsuppressible Insulin-Like Activity); 0 (Somatomedins); 0 (Tumor Necrosis Factor-alpha); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:8903
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:890301
[St] Status:MEDLINE


  6 / 111 MEDLINE  
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PubMed Central Texto completo
[PMID]:3593220
[Au] Autor:Cornell HJ; Enberg G; Herington AC
[Ti] Título:Preferential association of the insulin-like growth factors I and II with metabolically inactive and active carrier-bound complexes in serum.
[So] Source:Biochem J;241(3):745-50, 1987 Feb 01.
[Is] ISSN:0264-6021
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ion-exchange chromatography of serum on DEAE-Sephadex A-50 using a stepwise NaCl gradient showed that complexes enriched with insulin-like growth factors I and II (IGF-I and IGF-II) could be preferentially eluted. A fraction eluted with 0.075 M-NaCl preferentially contained immunoreactive IGF-I with peak levels appearing in fractions of Mr approx. 110,000. The IGF-I-binding protein complex itself had low bioactivity as measured in a non-suppressible insulin-like (NSILA) bioassay. On conversion to free IGF-I by gel-permeation chromatography on Sephadex G-75 in 1% formic acid, however, the IGF-I did express its intrinsic NSILA bioactivity. In contrast, an IGF-II-enriched complex was eluted from the DEAE-Sephadex with 0.15 M-NaCl. Practically all of the recovered NSILA of the original serum was present in this fraction, in the Mr range 70,000-300,000 with a peak of 150,000. Chromatography on Sephadex G-75 in 1% formic acid separated this high-Mr NSILA into low-Mr (less than 15000) IGF-II and high-Mr acid-stable NSILA-P. The high-Mr IGF-II complex bound to concanavalin A-Sepharose, suggesting that it was a glycoprotein. The results confirm previous reports that a large portion of the NSILA of whole serum can be accounted for by a biologically active acid-dissociable complex. These data show for the first time that this active complex consists of an IGF-II-preferring binding protein. In direct contrast, the IGF-I-preferring complex does not express NSILA bioactivity until the IGF-I is liberated through acidification. The presence of a metabolically active IGF-II complex in serum raises questions as to its possible biological role in the adult.
[Mh] Termos MeSH primário: Proteínas de Transporte/sangue
Fator de Crescimento Insulin-Like II/sangue
Fator de Crescimento Insulin-Like I/sangue
Somatomedinas/sangue
[Mh] Termos MeSH secundário: Cromatografia de Afinidade
Cromatografia por Troca Iônica
Seres Humanos
Fator de Crescimento Insulin-Like I/imunologia
Fator de Crescimento Insulin-Like II/imunologia
Substâncias Macromoleculares
Atividade Insulin-Like não Suprimível/imunologia
Atividade Insulin-Like não Suprimível/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Macromolecular Substances); 0 (Nonsuppressible Insulin-Like Activity); 0 (Somatomedins); 67763-96-6 (Insulin-Like Growth Factor I); 67763-97-7 (Insulin-Like Growth Factor II)
[Em] Mês de entrada:8707
[Cu] Atualização por classe:130929
[Lr] Data última revisão:
130929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:870201
[St] Status:MEDLINE


  7 / 111 MEDLINE  
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[PMID]:3425657
[Au] Autor:Samaan NA; Schultz PN; Johnston DA; Creasy RW; Gonik B
[Ad] Endereço:Section of Endocrinology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
[Ti] Título:Growth hormone, somatomedin C, and nonsuppressible insulin-like activity levels compared in premature, small, average birth weight, and large infants.
[So] Source:Am J Obstet Gynecol;157(6):1524-8, 1987 Dec.
[Is] ISSN:0002-9378
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We have investigated the relationship between growth hormone, somatomedin C, nonsuppressible insulin-like activity, weight, gestational age, and 1-minute Apgar score in newborn infants. The 153 infants were categorized as small for gestational age (n = 19), average for gestational age (n = 59), large for gestational age (n = 60), and premature (gestational age at birth, 36 weeks or less (n = 15). Our study showed that (1) growth hormone levels were elevated in premature infants and correlated with Apgar scores and birth weights; (2) somatomedin C and nonsuppressible insulin-like activity levels were significantly lower in premature than in term infants; and (3) the birth weight of all infants studied had a significant overall effect on both somatomedin C and nonsuppressible insulin-like activity levels, suggesting that these factors may be involved in fetal growth. However, because in small for gestational age infants somatomedin C and nonsuppressible insulin-like activity were similar to levels in average for gestational age infants, it is suggested that other factors may inhibit fetal growth.
[Mh] Termos MeSH primário: Hormônio do Crescimento/sangue
Recém-Nascido/sangue
Recém-Nascido Prematuro/sangue
Recém-Nascido Pequeno para a Idade Gestacional/sangue
Fator de Crescimento Insulin-Like I/sangue
Atividade Insulin-Like não Suprimível/análise
Somatomedinas/sangue
[Mh] Termos MeSH secundário: Índice de Apgar
Peso ao Nascer
Sangue Fetal/análise
Seres Humanos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Nonsuppressible Insulin-Like Activity); 0 (Somatomedins); 67763-96-6 (Insulin-Like Growth Factor I); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:8802
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:871201
[St] Status:MEDLINE


  8 / 111 MEDLINE  
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[PMID]:3096625
[Au] Autor:Khokher MA; Taylor AM; Dandona P
[Ti] Título:Similarities between the insulin-like stimulatory effect of human IgG and NSILP.
[So] Source:Diabetes Res;3(7):373-6, 1986 Sep.
[Is] ISSN:0265-5985
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Since the insulin-like stimulatory effect of human IgG on adipocyte lipogenesis, exerted through its Fc moiety, is not neutralized by anti-insulin antisera, IgG may contribute significantly to the non-suppressible insulin-like activity (NSILA) of plasma. 91% of NSILA has been shown previously to be associated with a high mol. wt. protein (NSILP). The purpose of this investigation was to assess whether IgG and NSILP have similar stimulatory effects on adipocyte lipogenesis and whether this effect can be neutralized by preincubation with gamma-chain specific anti-IgG antiserum; whether IgG stimulates 35S-sulphate uptake by porcine cartilage, known to be stimulated by insulin-like growth factors but not NSILP; and whether gamma-chain specific anti-IgG antisera precipitate IgG in a fashion similar to that with IgG preparations. Our investigations show that both IgG and NSILP have similar dose response relationships with respect to the stimulation of adipocyte lipogenesis and that both lose their adipocyte stimulating effect following preincubation with anti-IgG antiserum; neither IgG nor NSILP stimulate 35S-sulphate uptake by porcine cartilage, unlike serum somatomedin and crude NSILA-s preparations; and that gamma-chain specific anti-IgG antisera form precipitin lines with NSILP. Therefore, NSILP and IgG molecules have immunological and biological similarities; there may occur a homology between the Fc fragment of IgG and the NSILP molecule.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Cartilagem/metabolismo
Imunoglobulina G
Insulina
Atividade Insulin-Like não Suprimível/fisiologia
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Animais
Cartilagem/efeitos dos fármacos
Seres Humanos
Soros Imunes
Imunodifusão
Insulina/farmacologia
Lipídeos/biossíntese
Atividade Insulin-Like não Suprimível/farmacologia
Sulfatos/metabolismo
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immune Sera); 0 (Immunoglobulin G); 0 (Insulin); 0 (Lipids); 0 (Nonsuppressible Insulin-Like Activity); 0 (Sulfates)
[Em] Mês de entrada:8701
[Cu] Atualização por classe:111117
[Lr] Data última revisão:
111117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860901
[St] Status:MEDLINE


  9 / 111 MEDLINE  
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[PMID]:4065403
[Au] Autor:Cornell HJ; Bistrin M; Herington AC
[Ti] Título:Differentiation between carrier-bound forms of non-suppressible insulin-like activity (NSILA) in serum.
[So] Source:Int J Biochem;17(9):1003-8, 1985.
[Is] ISSN:0020-711X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gel-permeation chromatography of serum on Sephacryl S-300 at pH 7.4 has shown that NSILA was detected over a range of MW 50,000-400,000 with a peak at about MW 200,000. When fractions from the above chromatography were rechromatographed on Sephadex G-75 at pH 2.4 major amounts of acid-stable NSILA were found in a fraction of MW 200,000-600,000 (77% of the fraction NSILA or 28% of total serum NSILA). Further evidence was obtained for the presence of an active acid-dissociable complex in serum. This was present in both the MW 100,000-200,000 and 35,000-100,000 fractions and corresponded to 37% of total serum NSILA. Con-A Sepharose affinity chromatography of the serum fractions from Sephacryl S-300 chromatography, followed by Sephadex G-75 chromatography under acid conditions, showed that the acid-stable complex was consistently found in weakly bound materials. The active acid-dissociable complex was found in the bound fractions, especially in the Sephacryl S-300 pool of MW 35,000-100,000. Low MW NSILA (less than 15,000) was also released on acid treatment from an otherwise inactive high MW complex(es) of MW 35,000-600,000. This complex was not bound by Con-A Sepharose.
[Mh] Termos MeSH primário: Proteínas de Transporte/isolamento & purificação
Atividade Insulin-Like não Suprimível/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Cromatografia de Afinidade/métodos
Cromatografia em Gel/métodos
Seres Humanos
Peso Molecular
Valores de Referência
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Nonsuppressible Insulin-Like Activity); 0 (nonsuppressible insulin-like carrier protein, human)
[Em] Mês de entrada:8601
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:850101
[St] Status:MEDLINE


  10 / 111 MEDLINE  
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Fotocópia
[PMID]:4050920
[Au] Autor:Samaan NA; Vassilopoulou-Sellin R; Schultz PN; Rivera ME; Held B
[Ti] Título:Nonsuppressible insulin-like activity and somatomedin C levels in normal pregnant women, in pregnant women with gestational diabetes, and in umbilical cord blood of mature and premature infants.
[So] Source:Am J Obstet Gynecol;153(4):457-61, 1985 Oct 15.
[Is] ISSN:0002-9378
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was undertaken to determine the significance of the changes in nonsuppressible insulin-like activity as measured by the fat pad assay and by the levels of immunoreactive somatomedin C, growth hormone, and human placental lactogen in sera of term normal pregnant women, mothers who delivered prematurely, and women with gestational diabetes at term as compared to normal nonpregnant subjects. These hormones were also measured in the umbilical cord blood of these patients at the time of delivery to determine the possible mechanisms of the fetal growth in utero. Our investigations showed that (1) nonsuppressible insulin-like activity is elevated during pregnancy, but its level was lower in mothers with gestational diabetes in spite of significantly higher serum human placental lactogen compared with normal pregnant mothers; (2) nonsuppressible insulin-like activity is significantly lower in premature infants than in term infants; (3) somatomedin C levels were significantly elevated in pregnant mothers in spite of suppression of growth hormone; (4) nonsuppressible insulin-like activity and somatomedin C levels in infants of mothers with gestational diabetes were not significantly elevated in spite of higher birth weight, indicating that nonsuppressible insulin-like activity and somatomedins are not the only factors responsible for the increase of birth weight of children of diabetic mothers; (5) there was marked discordance between the growth hormone level in the neonates and somatomedin C levels.
[Mh] Termos MeSH primário: Sangue Fetal/análise
Fator de Crescimento Insulin-Like I/sangue
Atividade Insulin-Like não Suprimível/análise
Gravidez em Diabéticas/sangue
Gravidez
Somatomedinas/sangue
[Mh] Termos MeSH secundário: Adulto
Feminino
Hormônio do Crescimento/sangue
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Lactogênio Placentário/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Nonsuppressible Insulin-Like Activity); 0 (Somatomedins); 67763-96-6 (Insulin-Like Growth Factor I); 9002-72-6 (Growth Hormone); 9035-54-5 (Placental Lactogen)
[Em] Mês de entrada:8511
[Cu] Atualização por classe:071114
[Lr] Data última revisão:
071114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:851015
[St] Status:MEDLINE



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