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[PMID]:29383769
[Au] Autor:Oldenburger IB; Wolters VM; Kardol-Hoefnagel T; Houwen RHJ; Otten HG
[Ad] Endereço:Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.
[Ti] Título:Serum intestinal fatty acid-binding protein in the noninvasive diagnosis of celiac disease.
[So] Source:APMIS;126(3):186-190, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Current diagnostic guidelines for celiac disease (CD) in pediatric patients require a duodenal biopsy if the IgA anti-tissue transglutaminase (tTG) is below 10x the upper limit of normal (ULN). Additional markers may enable a noninvasive diagnosis in this group. Serum intestinal-fatty acid-binding protein (I-FABP), a marker for intestinal epithelial damage, could be useful in this respect. A total of 95 children with a clinical suspicion of CD and tTG 1-10x ULN were investigated. All had a duodenal biopsy and analysis of serum I-FABP. A control group of 161 children with familial short stature and normal tTG was included. I-FABP levels in the 71 patients with tTG 1-10x ULN and biopsy-proven CD (median 725 pg/mL) were not significantly different (p = 0.13) from the levels in the 24 patients with a tTG 1-10x ULN but a normal biopsy (median 497 pg/mL). However, when combining tTG and I-FABP levels, 11/24 patients could have been diagnosed noninvasively if tTG is ≥ 50 U/mL and I-FABP ≥880 pg/mL or in 12/19 patients if tTG is ≥ 60 U/mL and I-FABP ≥ 620 pg/mL. Therefore, addition of I-FABP to the diagnostic procedure of CD may provide a noninvasive diagnosis in patients with a tTG ≥ 50 U/mL.
[Mh] Termos MeSH primário: Doença Celíaca/diagnóstico
Doença Celíaca/patologia
Proteínas de Ligação a Ácido Graxo/sangue
Proteínas de Ligação ao GTP/imunologia
Imunoglobulina A/sangue
Transglutaminases/imunologia
[Mh] Termos MeSH secundário: Adolescente
Doença Celíaca/sangue
Criança
Pré-Escolar
Duodeno/patologia
Proteínas de Ligação a Ácido Graxo/metabolismo
Feminino
Antígenos HLA-DQ/sangue
Seres Humanos
Imunoglobulina A/imunologia
Lactente
Mucosa Intestinal/patologia
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FABP2 protein, human); 0 (Fatty Acid-Binding Proteins); 0 (HLA-DQ Antigens); 0 (HLA-DQ2 antigen); 0 (HLA-DQ8 antigen); 0 (Immunoglobulin A); EC 2.3.2.- (transglutaminase 2); EC 2.3.2.13 (Transglutaminases); EC 2.3.2.13 (transglutaminase 1); EC 3.6.1.- (GTP-Binding Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12800


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[PMID]:27779102
[Au] Autor:Al Fayi MS; Gou X; Forootan SS; Al-Jameel W; Bao Z; Rudland PR; Cornford PA; Hussain SA; Ke Y
[Ad] Endereço:Molecular Pathology Laboratory, Department of Molecular and Clinical Cancer Medicine, Liverpool University, the Cancer Research Centre Building, Liverpool, United Kingdom.
[Ti] Título:The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance.
[So] Source:Oncotarget;7(50):82783-82797, 2016 Dec 13.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the possible involvement of other FABPs are rare. Here we first measured the mRNA levels of 10 FABPs in benign and malignant prostate cell lines and identified the differentially expressed FABP6 and FABP9 mRNAs whose levels in all malignant cell lines were higher than those in the benign cells. Thereafter we assessed the expression status of FABP6 and FABP9 in both prostate cell lines and in human tissues. FABP6 protein was overexpressed only in 1 of the 5 malignant cell lines and its immunostaining intensities were not significantly different between benign and malignant prostate tissues. In contrast, FABP9 protein was highly expressed in highly malignant cell lines PC-3 and PC3-M, but its level in the benign PNT-2 and other malignant cell lines was not detectable. When analysed in an archival set of human prostate tissues, immunohistochemical staining intensity for FABP9 was significantly higher in carcinomas than in benign cases and the increase in FABP9 was significantly correlated with reduced patient survival times. Moreover, the increased level of staining for FABP9 was significantly associated with the increased joint Gleason scores (GS) and androgen receptor index (AR). Suppression of FABP9 expression in highly malignant PC3-M cells inhibited their invasive potential. Our results suggest that FABP9 is a valuable prognostic marker to predict the outcomes of prostate cancer patients, perhaps by playing an important role in prostate cancer cell invasion.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Proteínas de Ligação a Ácido Graxo/metabolismo
Neoplasias da Próstata/metabolismo
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/genética
Linhagem Celular Tumoral
Movimento Celular
Proteínas de Ligação a Ácido Graxo/genética
Hormônios Gastrointestinais/genética
Hormônios Gastrointestinais/metabolismo
Seres Humanos
Imuno-Histoquímica
Estimativa de Kaplan-Meier
Masculino
Gradação de Tumores
Invasividade Neoplásica
Valor Preditivo dos Testes
Neoplasias da Próstata/genética
Neoplasias da Próstata/patologia
Neoplasias da Próstata/terapia
Interferência de RNA
RNA Mensageiro/genética
Receptores Androgênicos/metabolismo
Fatores de Tempo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AR protein, human); 0 (Biomarkers, Tumor); 0 (Fatty Acid-Binding Proteins); 0 (Gastrointestinal Hormones); 0 (RNA, Messenger); 0 (Receptors, Androgen); 117849-44-2 (fatty acid-binding protein 6)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.12635


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[PMID]:29363927
[Au] Autor:Chernyak OO; Sentsova TB; Vorozhko IV; Tutelyan VA; Gapparova KM; Borodina SV
[Ti] Título:[Genomic, proteomic and metabolomic predictors of atherosclerosis in obese patients. Part II].
[So] Source:Vopr Pitan;84(5):39-45, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Currently there is no extensive research of metabolic disorders in obese patients with atherosclerosis, including the study of genomic, biochemical, immune and other markers. Therefore, the aim of the study was to identify the genomic, proteomic and metabolic predictors of atherosclerosis in obese patients. We evaluated condition of the cardiovascular system of the 100 obese patients aged 18 to 66 years, which were divided in two groups of patients: Group 1 consisted of 50 obese patients without vascular pathology, 2nd group consisted of 50 patients with obesity, complicated by atherosclerosis. We carried out a study of the lipid metabolism and analysis of polymorphic alleles ε2, ε3, ε4 of the ApoE gene by PCR. Our data showed that clinically significant predictors of atherosclerosis in obese patients are homozygous genotypes ε2/ε2 of the ApoE gene, increased blood serum level of triglycerides, oxidated LDL, interleukin-6, adhesion molecules SICAM, L-FABP and adiponectin reduction.
[Mh] Termos MeSH primário: Aterosclerose
Metabolômica
Obesidade
Proteômica
[Mh] Termos MeSH secundário: Adiponectina/sangue
Adolescente
Adulto
Idoso
Apolipoproteínas E/sangue
Apolipoproteínas E/genética
Aterosclerose/sangue
Aterosclerose/etiologia
Aterosclerose/genética
Biomarcadores/sangue
Proteínas de Ligação a Ácido Graxo/sangue
Feminino
Seres Humanos
Interleucina-6/sangue
Lipoproteínas LDL/sangue
Masculino
Meia-Idade
Obesidade/sangue
Obesidade/complicações
Obesidade/genética
Polimorfismo Genético
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (Adiponectin); 0 (Apolipoproteins E); 0 (Biomarkers); 0 (Fatty Acid-Binding Proteins); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (Lipoproteins, LDL); 0 (Triglycerides); 0 (oxidized low density lipoprotein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:29281659
[Au] Autor:Mwape I; Bosomprah S; Mwaba J; Mwila-Kazimbaya K; Laban NM; Chisenga CC; Sijumbila G; Simuyandi M; Chilengi R
[Ad] Endereço:Center for Infectious Disease Research in Zambia, Lusaka, Zambia.
[Ti] Título:Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction.
[So] Source:PLoS One;12(12):e0187761, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Deployment of rotavirus vaccines has contributed to significant declines in diarrheal morbidity and mortality globally. Unfortunately, vaccine performance in low-middle income countries (LMICs) is generally lower than in developed countries. The cause for this has been associated with several host and maternal factors including poor water sanitation and hygiene (WASH) status, which are predominant in LMICs. More recently, environmental enteric dysfunction (EED) has specifically been hypothesized to contribute to poor vaccine uptake and response. The aim of this study was to examine the association between serological biomarkers of EED and seroconversion to rotavirus vaccine in Zambian infants. METHODS: This was a retrospective cohort study of 142 infants who had been fully immunized with Rotarix™, and had known seroconversion status. Seroconversion was defined as 4-fold or more increase in rotavirus-specific IgA titres between pre-vaccination and one month post-dose two vaccination. We performed ELISA assays to assess soluble CD14 (sCD14), Endotoxin Core IgG Antibodies (EndoCAb), intestinal fatty acid binding protein (i-FABP) and Zonulin according to the manufacturers protocols. Generalised linear model with family-poisson, link-log and robust standard error was used to estimate the independent effects of biomarkers on seroconversion adjusting for important cofounders. RESULTS: The median concentration of Zonulin, Soluble CD14, EndoCaB, and IFABP were 209.3 (IQR = 39.7, 395.1), 21.5 (IQR = 21.5, 21.5), 0.3 (IQR = 0.3, 0.3), and 107.7 (IQR = 6.4, 1141.4) respectively. In multivariable analyses adjusting for the independent effect of other biomarkers and confounders (i.e. age of child at vaccination, breast-milk anti-rotavirus IgA, infant serum anti-rotavirus IgG, and IgA seropositivity at baseline), there was strong evidence of about 24% increase in seroconversion due to doubling Zonulin concentration (Adjusted risk ratio (aRR) = 1.24; 95% CI = 1.12 to1.37; p<0.0001). Similarly, we found about 7% increase in seroconversion due to doubling IFABP concentration (aRR = 1.07; 95% CI = 1.02 to 1.13; p = 0.006). CONCLUSION: We found that high levels of zonulin and IFABP played a role in seroconversion. It is plausible that increased gut permeability in EED allows greater uptake of the live virus within the vaccine, but later consequences result in deleterious local structural distortions and malabsorption syndromes.
[Mh] Termos MeSH primário: Enteropatias/imunologia
Vacinas contra Rotavirus/imunologia
[Mh] Termos MeSH secundário: Anticorpos Antivirais/biossíntese
Anticorpos Antivirais/imunologia
Biomarcadores/sangue
Ensaio de Imunoadsorção Enzimática
Proteínas de Ligação a Ácido Graxo/imunologia
Feminino
Seres Humanos
Imunoglobulina A/sangue
Imunoglobulina G/sangue
Lactente
Receptores de Lipopolissacarídeos/imunologia
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Biomarkers); 0 (Fatty Acid-Binding Proteins); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Lipopolysaccharide Receptors); 0 (Rotavirus Vaccines)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187761


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[PMID]:29198193
[Au] Autor:Cai Z; Mai K; Ai Q
[Ad] Endereço:Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture) & Key Laboratory of Mariculture (Ministry of Education),Ocean University of China,5 Yushan Road,Qingdao,Shandong 266003,People's Republic of China.
[Ti] Título:Regulation of hepatic lipid deposition by phospholipid in large yellow croaker.
[So] Source:Br J Nutr;118(12):999-1009, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dietary phospholipid (PL) supplementation has been shown to reduce lipid accumulation in the tissues of farmed fish; however, the mechanisms underlying this effect are largely unknown. Thus, the present study was conducted to evaluate the potential impacts of PL on hepatic lipid metabolism both in vivo and in vitro. For in vivo study, four experimental diets - low lipid and low PL diet, as control diet (LL-LP diet, containing 12 % lipid and 1·5 % PL), low-lipid and high-PL diet (containing 12 % lipid and 8 % PL), high-lipid and low-PL diet (HL-LP diet, containing 20 % lipid and 1·5 % PL) and high-lipid and high-PL diet (HL-HP diet, containing 20 % lipid and 8 % PL) - were randomly allocated to four groups of large yellow croaker (Larimichthys crocea) (three cages per group) with similar initial body weight (approximately 8 g). For in vitro study, primary hepatocytes isolated from large yellow croaker were incubated either with graded levels of phosphatidylcholine (PC) (0-250 µm) or small interfering RNA (siRNA) for CTP: choline phosphate cytidylyltranferase α (CCTα) (siRNA-CCTα). Results showed that survival was independent of dietary treatments (P>0·05). Weight gain and feed efficiency in the HL-HP group were significantly higher than in the LL-LP and HL-LP groups (P<0·05). High level of dietary PL could markedly reduce abnormal hepatic lipid accumulation induced by the HL-LP diet (P<0·05). Similarly, compared with the corresponding controls, a significant decrease/increase in lipid content was observed in primary hepatocytes incubated with PC/siRNA-CCTα (P<0·05). High level of dietary PL reversed the HL-LP diet-induced increased levels of mRNA of fatty acid uptake and lipid synthesis related genes (P<0·05). In addition, High level of dietary PL markedly down-regulated the transcript levels of fatty acid oxidation-related genes and enhanced the transcript levels of VLDL assembly-related genes regardless of dietary lipid levels (P<0·05). Compared with corresponding controls, primary hepatocytes treated with PC showed significantly higher mRNA expression of lipid synthesis and VLDL assembly-related genes and lower mRNA expression of fatty acid oxidation-related genes, with hepatocytes treated with siRNA-CCTα exhibiting the opposite trend (P<0·05). In summary, these results demonstrated that high level of dietary PL might reverse the HL-LP diet-induced abnormal lipid accumulation in the liver through inhibiting fatty acid uptake and lipid synthesis, together with promoting the lipid export at the transcriptional level. Lipid export-promoting effect of PC was confirmed by in vitro studies. The present study showed for the first time that PL or PC could influence various metabolic pathways to regulate hepatic lipid deposition in fish at least at the transcriptional level.
[Mh] Termos MeSH primário: Dieta/veterinária
Metabolismo dos Lipídeos
Fígado/metabolismo
Perciformes/metabolismo
Fosfolipídeos/administração & dosagem
[Mh] Termos MeSH secundário: Ração Animal
Animais
Antígenos CD36/genética
Antígenos CD36/metabolismo
Células Cultivadas
Diacilglicerol O-Aciltransferase/genética
Diacilglicerol O-Aciltransferase/metabolismo
Ácido Graxo Sintases/genética
Ácido Graxo Sintases/metabolismo
Proteínas de Transporte de Ácido Graxo/genética
Proteínas de Transporte de Ácido Graxo/metabolismo
Proteínas de Ligação a Ácido Graxo/genética
Proteínas de Ligação a Ácido Graxo/metabolismo
Ácidos Graxos/metabolismo
Proteínas de Peixes/genética
Proteínas de Peixes/metabolismo
Hepatócitos/metabolismo
Lipase/genética
Lipase/metabolismo
Lipase Lipoproteica/genética
Lipase Lipoproteica/metabolismo
Fosfatidilcolinas/administração & dosagem
Proteína de Ligação a Elemento Regulador de Esterol 1/genética
Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD36 Antigens); 0 (Fatty Acid Transport Proteins); 0 (Fatty Acid-Binding Proteins); 0 (Fatty Acids); 0 (Fish Proteins); 0 (Phosphatidylcholines); 0 (Phospholipids); 0 (Sterol Regulatory Element Binding Protein 1); EC 2.3.1.20 (Diacylglycerol O-Acyltransferase); EC 2.3.1.85 (Fatty Acid Synthases); EC 3.1.1.3 (Lipase); EC 3.1.1.34 (Lipoprotein Lipase)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1017/S000711451700294X


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[PMID]:29066304
[Au] Autor:Bahnamiri HZ; Zali A; Ganjkhanlou M; Sadeghi M; Shahrbabak HM
[Ad] Endereço:Department of Animal Science, University of Tehran, P.O. Box # 3158711167-4111, Karaj, Iran. Electronic address: h.zakariapour@ut.ac.ir.
[Ti] Título:Regulation of lipid metabolism in adipose depots of fat-tailed and thin-tailed lambs during negative and positive energy balances.
[So] Source:Gene;641:203-211, 2018 Jan 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the effects of negative and positive energy balances on gene expression of regulators and enzymes controlling lipogenesis and lipolysis in muscle and adipose depots of fat-tailed and thin-tailed lambs. Lambs were slaughtered during neutral, negative and positive energy balances for sample collection. Real time q-PCR was conducted to measure the gene expression. Expression of PPARγ was increased in response to positive energy balance regardless of genotype and type of tissue (P<0.04). Expression of SREBF1 was reduced in response to negative and positive energy balances in fat-tailed lambs, whereas in thin-tailed lambs, downregulated SREBF1 was restored during positive energy balance (P<0.01). Enhancement in FABP4 expression in response to negative and positive energy balances was respectively higher in thin-tailed and fat-tailed lambs affected by interaction of genotype and energy balance (P<0.11). In thin-tailed lambs, the enhanced FABP4 expression in response to negative energy balance was considerably higher in mesenteric adipose depot, whereas in fat-tailed lambs, positive energy balance induced enhancement in FABP4 expression was considerably higher in fat-tail adipose depot. The results demonstrate that transcription regulation of lipogenesis and lipolysis during negative and positive energy balances occurs differently in fat-tailed and thin-tailed lambs. Thin-tailed and fat-tailed lambs are respectively more responsive to negative and positive energy balances and mesenteric and fat-tail adipose depots respectively in thin-tailed and fat-tailed lambs are the main adipose depots responsible for higher responsiveness of thin-tailed and fat-tailed lambs to negative and positive energy balances.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Metabolismo Energético/genética
Expressão Gênica/genética
Metabolismo dos Lipídeos/genética
[Mh] Termos MeSH secundário: Animais
Regulação para Baixo/genética
Gorduras/metabolismo
Proteínas de Ligação a Ácido Graxo/genética
Lipogênese/genética
Lipólise/genética
Masculino
Ovinos
Proteína de Ligação a Elemento Regulador de Esterol 1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fats); 0 (Fatty Acid-Binding Proteins); 0 (Sterol Regulatory Element Binding Protein 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE


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[PMID]:29016489
[Au] Autor:Tu WJ; Guo M; Shi XD; Cai Y; Liu Q; Fu CW
[Ad] Endereço:Institute of Radiation Medicine, China Academy of Medical Science & Peking Union Medical College, Tianjin, the Department of Laboratory, China Rehabilitation Research Center, Beijing, the Departments of Endocrinology and Gynaecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, and the Department of Gynaecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China.
[Ti] Título:First-Trimester Serum Fatty Acid-Binding Protein 4 and Subsequent Gestational Diabetes Mellitus.
[So] Source:Obstet Gynecol;130(5):1011-1016, 2017 Nov.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To examine whether plasma fatty acid-binding protein 4 concentrations, measured in the first trimester, are associated with gestational diabetes mellitus (GDM). METHODS: This prospective, multicenter cohort study was conducted at three maternity centers in two cities (Harbin and Beijing) in China from July 2015 to June 2016. Data for fasting plasma glucose and fatty acid-binding protein 4 concentrations in the first trimester and one-step GDM screening with a 75-g oral glucose tolerance test performed between 24 and 28 weeks of gestation were collected and analyzed. RESULTS: Plasma from women in the first trimester was available for 1,150 women, of whom 135 (11.7%) developed GDM. The GDM distribution across the fatty acid-binding protein 4 quartiles ranged from 3.8% (first quartile) to 21.6% (fourth quartile). In multivariate models comparing the second (quartile 2), third, and fourth quartiles against the first quartile of fatty acid-binding protein 4, concentrations of fatty acid-binding protein 4 in quartile 2, quartile 3, and quartile 4 were associated with the development of GDM with respective associated adjusted odds ratios (95% CIs) of 1.76 (1.21-2.58), 2.36 (1.55-4.29), and 3.57 (1.99-6.11). A significant difference in the area under receiver operating characteristic curve between established risk factors alone and the addition of fatty acid-binding protein 4 concentrations was observed (difference 0.042 [95% CI 0.028-0.055]; P=.03). CONCLUSIONS: Higher fatty acid-binding protein 4 concentrations in the first trimester visit were associated with increased risk of GDM and might be useful in identifying women at risk for GDM for early prevention strategies.
[Mh] Termos MeSH primário: Diabetes Gestacional/etiologia
Proteínas de Ligação a Ácido Graxo/sangue
Primeiro Trimestre da Gravidez/sangue
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Glicemia/análise
China
Diabetes Gestacional/diagnóstico
Jejum/sangue
Feminino
Teste de Tolerância a Glucose
Seres Humanos
Análise Multivariada
Razão de Chances
Gravidez
Estudos Prospectivos
Curva ROC
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Blood Glucose); 0 (FABP4 protein, human); 0 (Fatty Acid-Binding Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002310


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[PMID]:28934432
[Au] Autor:Prendergast AJ; Chasekwa B; Rukobo S; Govha M; Mutasa K; Ntozini R; Humphrey JH
[Ad] Endereço:Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
[Ti] Título:Intestinal Damage and Inflammatory Biomarkers in Human Immunodeficiency Virus (HIV)-Exposed and HIV-Infected Zimbabwean Infants.
[So] Source:J Infect Dis;216(6):651-661, 2017 Sep 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Disease progression is rapid in human immunodeficiency virus (HIV)-infected infants. Whether intestinal damage and inflammation underlie mortality is unknown. Methods: We measured plasma intestinal fatty acid binding protein (I-FABP), soluble CD14 (sCD14), interleukin 6 (IL-6), and C-reactive protein (CRP) at 6 weeks and 6 months of age in 272 HIV-infected infants who either died (cases) or survived (controls), and in 194 HIV-exposed uninfected (HEU) and 197 HIV-unexposed infants. We estimated multivariable odds ratios for mortality and postnatal HIV transmission for each biomarker using logistic regression. Results: At 6 weeks, HIV-infected infants had higher sCD14 and IL-6 but lower I-FABP than HIV-exposed and HIV-unexposed infants (P < .001). CRP was higher in HIV-exposed than HIV-unexposed infants (P = .02). At 6 months, HIV-infected infants had highest sCD14, IL-6, and CRP concentrations (P < .001) and marginally higher I-FABP than other groups (P = .07). CRP remained higher in HIV-exposed vs HIV-unexposed infants (P = .04). No biomarker was associated with mortality in HIV-infected infants, or with odds of breast-milk HIV transmission in HIV-exposed infants. Conclusions: HIV-infected infants have elevated inflammatory markers by 6 weeks of age, which increase over time. In contrast to adults and older children, inflammatory biomarkers were not associated with mortality. HEU infants have higher inflammation than HIV-unexposed infants until at least 6 months, which may contribute to poor health outcomes.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Infecções por HIV/sangue
Intestinos/patologia
Intestinos/virologia
[Mh] Termos MeSH secundário: Proteína C-Reativa/metabolismo
Estudos de Casos e Controles
Relação Dose-Resposta a Droga
Proteínas de Ligação a Ácido Graxo/sangue
Feminino
HIV/isolamento & purificação
HIV/metabolismo
Infecções por HIV/diagnóstico
Seres Humanos
Lactente
Inflamação/sangue
Inflamação/virologia
Interleucina-6/sangue
Receptores de Lipopolissacarídeos/sangue
Masculino
Análise Multivariada
Ensaios Clínicos Controlados Aleatórios como Assunto
Tamanho da Amostra
Zimbábue/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (FABP2 protein, human); 0 (Fatty Acid-Binding Proteins); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (Lipopolysaccharide Receptors); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix367


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[PMID]:28911862
[Au] Autor:Jung J; Wang J; Groenendyk J; Lee D; Michalak M; Agellon LB
[Ad] Endereço:Departments of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
[Ti] Título:Fatty acid binding protein (Fabp) 5 interacts with the calnexin cytoplasmic domain at the endoplasmic reticulum.
[So] Source:Biochem Biophys Res Commun;493(1):202-206, 2017 Nov 04.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calnexin is a type 1 integral endoplasmic reticulum membrane molecular chaperone with an endoplasmic reticulum luminal chaperone domain and a highly conserved C-terminal domain oriented to the cytoplasm. Fabp5 is a cytoplasmic protein that binds long-chain fatty acids and other lipophilic ligands. Using a yeast two-hybrid screen, immunoprecipitation, microscale thermophoresis analysis and cellular fractionation, we discovered that Fabp5 interacts with the calnexin cytoplasmic C-tail domain at the endoplasmic reticulum. These observations identify Fabp5 as a previously unrecognized calnexin binding partner.
[Mh] Termos MeSH primário: Calnexina/química
Calnexina/metabolismo
Citoplasma/metabolismo
Retículo Endoplasmático/metabolismo
Proteínas de Ligação a Ácido Graxo/metabolismo
Fibroblastos/metabolismo
Proteínas de Neoplasias/metabolismo
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Células Cultivadas
Citoplasma/química
Retículo Endoplasmático/química
Proteínas de Ligação a Ácido Graxo/química
Fibroblastos/química
Camundongos
Proteínas de Neoplasias/química
Ligação Proteica
Domínios Proteicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fabp5 protein, mouse); 0 (Fatty Acid-Binding Proteins); 0 (Neoplasm Proteins); 139873-08-8 (Calnexin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


  10 / 4629 MEDLINE  
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[PMID]:28853554
[Au] Autor:Martin GG; Huang H; McIntosh AL; Kier AB; Schroeder F
[Ad] Endereço:Department of Physiology and Pharmacology, Texas A&M University , College Station, Texas 77843-4466, United States.
[Ti] Título:Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant.
[So] Source:Biochemistry;56(38):5147-5159, 2017 Sep 26.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using recombinant human wild-type fatty acid binding protein 1 (WT FABP1 T94T) and a variant (FABP1 T94A) protein, fluorescence binding assays, and circular dichroism, it was shown for the first time that WT FABP1 and the T94A variant each have a single, relatively hydrophobic site for binding fluorescent NBD-labeled analogues of N-arachidonoylethanolamide and 2-arachidonoylglycerol with high affinity. Most native N-acylethanolamides (NAEs) but only one 2-monoacylglycerol [i.e., 2-arachidonoylglycerol (2-AG)] displaced WT FABP1-bound fluorescently labeled endocannabinoids (ECs). While the T94A variant did not differ in affinity for AEA and most other NAEs, it exhibited a modestly higher affinity for OEA, as well as a higher affinity for 2-AG. Binding of AEA and 2-AG altered WT FABP1's secondary structure more extensively than any other previously examined ligand did. The T94A variant without a ligand was more susceptible to temperature-induced unfolding. While the T94A variant was much less sensitive to ligand (i.e., AEA or 2-AG)-induced conformational change, nevertheless binding of AEA and 2-AG significantly stabilized the T94A structure to thermal unfolding. These data provide the first evidence that ECs not only bind to but also alter the secondary structure of the human FABP1, with the latter markedly impacted by the T94A substitution, a variant strongly associated with hepatic accumulation of lipids and non-alcoholic fatty liver disease (NAFLD). Importantly, NAFLD has been associated with elevated hepatic levels of ECs and FABP1.
[Mh] Termos MeSH primário: Endocanabinoides/metabolismo
Proteínas de Ligação a Ácido Graxo/química
Proteínas de Ligação a Ácido Graxo/metabolismo
[Mh] Termos MeSH secundário: Animais
Ácidos Araquidônicos/metabolismo
Sítios de Ligação
Dicroísmo Circular
Endocanabinoides/química
Proteínas de Ligação a Ácido Graxo/genética
Fluorescência
Glicerídeos/metabolismo
Seres Humanos
Alcamidas Poli-Insaturadas/metabolismo
Estrutura Secundária de Proteína
Ratos
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arachidonic Acids); 0 (Endocannabinoids); 0 (FABP1 protein, human); 0 (Fabp1 protein, rat); 0 (Fatty Acid-Binding Proteins); 0 (Glycerides); 0 (Polyunsaturated Alkamides); 8D239QDW64 (glyceryl 2-arachidonate); UR5G69TJKH (anandamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00647



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