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[PMID]:28953987
[Au] Autor:Li L; Zou C; Zhou Z; Yu X
[Ad] Endereço:Department of Gastrointestinal Surgery, Tianjin Nankai Hospital, Tianjin, China.
[Ti] Título:Effects of herbal medicine Sijunzi decoction on rabbits after relieving intestinal obstruction.
[So] Source:Braz J Med Biol Res;50(11):e6331, 2017 Sep 21.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Intestinal obstruction leads to blockage of the movement of intestinal contents. After relieving the obstruction, patients might still suffer with compromised immune function and nutritional deficiency. This study aimed to evaluate the effects of Sijunzi decoction on restoring the immune function and nutritional status after relieving the obstruction. Experimental rabbits (2.5±0.2 kg) were randomly divided into normal control group, 2-day intestinal obstruction group, 2-day natural recovery group, 4-day natural recovery group, 2-day treated group, and 4-day treated group. Sijunzi decoction was given twice a day to the treated groups. The concentration of markers was analyzed to evaluate the immune function and nutritional status. The concentration of interleukin-2, immunoglobulins and complement components of the treated groups were significantly higher than the natural recovery group (P<0.05). The levels of CD4+ and CD4+/CD8+ increased then decreased in the treated groups. The levels of tumor necrosis factor-α and CD8+ were significantly lower than the natural recovery group. The level of total protein in the treated groups also increased then decreased after relieving the obstruction. The levels of albumin, prealbumin and insulin-like growth factor-1 were significantly higher in the treated groups than in the natural recovery group (P<0.05). Transferrin level in the treated groups was significantly higher than the obstruction group (P<0.05). Sijunzi decoction can lessen the inflammatory response and improve the nutrition absorption after relieving the obstruction.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Sistema Imunitário/efeitos dos fármacos
Obstrução Intestinal/imunologia
Estado Nutricional/efeitos dos fármacos
Fitoterapia/métodos
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD4-Positivos/citologia
Linfócitos T CD8-Positivos/citologia
Interleucina-2/análise
Obstrução Intestinal/reabilitação
Contagem de Linfócitos
Coelhos
Distribuição Aleatória
Recuperação de Função Fisiológica/efeitos dos fármacos
Reprodutibilidade dos Testes
Albumina Sérica/análise
Transferrinas/sangue
Fator de Necrose Tumoral alfa/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Interleukin-2); 0 (Serum Albumin); 0 (Transferrins); 0 (Tumor Necrosis Factor-alpha); 0 (si-jun-zi-tang)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28421565
[Au] Autor:Chrobak C; Sidler JA; O'Meara A; Schaedelin S; Hug BL
[Ad] Endereço:Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
[Ti] Título:Iron homeostasis in inflammation: a single centre prospective observational study in medical inpatients.
[So] Source:Swiss Med Wkly;147:w14431, 2017 04 19.
[Is] ISSN:1424-3997
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:AIMS OF THE STUDY: We aimed to assess a potential association of iron status with mortality and morbidity of inpatients with systemic inflammation. METHODS: This was a single centre prospective observational study. From April 2014 to October 2014, all consecutive medical inpatients aged >=18 years with a C-reactive protein value >5 mg/l on hospital admission were eligible for the study. We excluded pregnant women and patients with terminal renal insufficiency or past allogeneic stem cell transplantation. For all patients, a complete set of serum iron parameters was obtained on hospital admission. In the final analysis, the in-hospital all-cause mortality and several morbidity measures (length of stay, number of secondary diagnoses and Charlson Comorbidity Index) were compared between four distinct iron status groups: patients having iron deficiency anaemia, iron deficiency without anaemia, anaemia without iron deficiency, and normal iron status. Iron deficiency was quantifies as the serum transferrin receptor / ferritin index, with a cut-off level of 1.5. RESULTS: A total of 438 patients were included in the final analysis. Patients with iron deficiency had a higher in-hospital mortality than patients with iron deficiency anaemia, anaemia without iron deficiency, or normal iron status (6% vs 1%, 5%, and 1%, respectively; p = 0.042). Patients with iron deficiency anaemia had a higher number of secondary diagnoses (mean 8.4; standard deviation 4.2) and a higher Charlson Comorbidity Index (mean 1.8; standard deviation 1.9) than patients with iron deficiency, anaemia without iron deficiency, or normal iron status (p <0.001 and p <0.001, respectively). The median length of stay did not differ significantly between the iron status groups (p = 0.080). CONCLUSIONS: In our study population, iron status was significantly associated with mortality and morbidity. Further studies are required to assess the pathophysiological and clinical effects of an altered iron metabolism and iron substitution therapies in inflammation.
[Mh] Termos MeSH primário: Anemia Ferropriva/sangue
Homeostase
Inflamação/complicações
Ferro/deficiência
[Mh] Termos MeSH secundário: Idoso
Feminino
Ferritinas/sangue
Mortalidade Hospitalar
Seres Humanos
Ferro/sangue
Masculino
Meia-Idade
Estudos Prospectivos
Transferrinas/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Transferrins); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


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[PMID]:28356190
[Au] Autor:Yamagami M; Matsui Y; Hayakawa T; Yamamoto S; Kinoshita M; Suzuki S
[Ad] Endereço:Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, Japan. Electronic address: 1111610111a@kindai.ac.jp.
[Ti] Título:Plug-plug kinetic capillary electrophoresis for in-capillary exoglycosidase digestion as a profiling tool for the analysis of glycoprotein glycans.
[So] Source:J Chromatogr A;1496:157-162, 2017 May 05.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An online exoglycosidase digestion was combined with a plug-plug kinetic mode of capillary electrophoresis (CE) for the analysis of glycoprotein-derived oligosaccharides. An exoglycosidase solution and a solution of glycoprotein glycans derivatized with 8-aminopyrene-1,3,6-trisulfonic acid (APTS) were introduced to a neutrally coated capillary previously filled with electrophoresis buffer solution containing 0.5w/v% hydroxypropylcellulose. After immersion of both ends of the capillary in the buffer solutions, a negative voltage was applied for analysis. An APTS group of an oligosaccharide derivative has triply negative charges, which forced saccharide derivatives to anode with fast mobility and pass through the enzyme plug, which are detected at the anodic end. If the terminal monosaccharides of APTS-labeled oligosaccharides are released by the action of an exoglycosidase, the migration times of the oligosaccharides shift to those of digested oligosaccharides. We examined ß-galactosidase, α-mannosidase, ß-N-acetylhexosaminidase, α-neuraminidase, and α-fucosidase, and found only ß-galactosidase and α-neuraminidase showed good reactivity toward APTS-labeled oligosaccharides; the reaction was completed by injecting a 3.6cm long plug of 200 and 50mU/mL concentration of exoglycosidases. In contrast, other exoglycosidases could not react with APTS labeled oligosaccharides at a concentration up to 5U/mL. The ß-N-acetylhexosaminidase reaction was successively followed by the electrophoretic mobility of APTS oligosaccharides and stopped for 10min when saccharide derivatives were achieved in the enzyme plug. The reaction of α-fucosidase and α-mannosidase was completed by decreasing the electrophoretic voltage to -2kV when the APTS oligosaccharides were passing through an exoglycosidase plug. We established the CE conditions for all of the glycosidic linkage analysis of glycoprotein glycans.
[Mh] Termos MeSH primário: Eletroforese Capilar
Glicosídeo Hidrolases/metabolismo
Oligossacarídeos/análise
Polissacarídeos/metabolismo
[Mh] Termos MeSH secundário: Neuraminidase/metabolismo
Oligossacarídeos/química
Oligossacarídeos/isolamento & purificação
Polissacarídeos/química
Pirenos/química
Especificidade por Substrato
Transferrinas/metabolismo
beta-Galactosidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-aminopyrene-1,3,6-trisulfonic acid); 0 (Oligosaccharides); 0 (Polysaccharides); 0 (Pyrenes); 0 (Transferrins); EC 3.2.1.- (Glycoside Hydrolases); EC 3.2.1.18 (Neuraminidase); EC 3.2.1.23 (beta-Galactosidase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:27621245
[Au] Autor:Helmersson-Karlqvist J; Ridefelt P; Lind L; Larsson A
[Ad] Endereço:Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
[Ti] Título:Reference values for 34 frequently used laboratory tests in 80-year-old men and women.
[So] Source:Maturitas;92:97-101, 2016 Oct.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Reference values are usually based on blood samples from healthy individuals in the age range 20-50 years. Most patients seeking health care are older than this reference population. Many reference intervals are age dependent and there is thus a need to have appropriate reference intervals also for elderly individuals. METHODS: We analyzed a group of frequently used laboratory tests in an 80-year-old population (n=531, 266 females and 265 males). The 2.5th and 97.5th percentiles for these markers were calculated according to the International Federation of Clinical Chemistry guidelines on the statistical treatment of reference values. RESULTS: Reference values are reported for serum alanine transaminase (ALT), albumin, alkaline phosphatase, pancreatic amylase, apolipoprotein A1, apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio, aspartate aminotransferase (AST), AST/ALT ratio, bilirubin, calcium, calprotectin, cholesterol, HDL-cholesterol, creatinine kinase (CK), creatinine, creatinine estimated GFR, C-reactive protein, cystatin C, cystatin C estimated GFR, gamma-glutamyltransferase (GGT), iron, iron saturation, lactate dehydrogenase (LDH), magnesium, phosphate, transferrin, triglycerides, urate, urea, zinc, hemoglobin, platelet count and white blood cell count. The upper reference limit for creatinine and urea was significantly increased while the lower limit for iron and albumin was decreased in this elderly population in comparison with the population in the Nordic Reference Interval Project (NORIP). CONCLUSIONS: Reference values calculated from the whole population and a subpopulation without cardiovascular disease showed strong concordance. Several of the reference interval limits were outside the 90% confidence interval of NORIP.
[Mh] Termos MeSH primário: Apolipoproteínas/sangue
Enzimas/sangue
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Bilirrubina/sangue
Proteína C-Reativa/metabolismo
Cálcio/sangue
HDL-Colesterol/sangue
Creatinina/sangue
Cistatina C/sangue
Feminino
Taxa de Filtração Glomerular
Hemoglobinas/metabolismo
Seres Humanos
Ferro/sangue
Contagem de Leucócitos
Complexo Antígeno L1 Leucocitário/sangue
Magnésio/sangue
Masculino
Fosfatos/sangue
Contagem de Plaquetas
Valores de Referência
Albumina Sérica/metabolismo
Transferrinas/sangue
Triglicerídeos/sangue
Ureia/sangue
Ácido Úrico/sangue
Zinco/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins); 0 (Cholesterol, HDL); 0 (Cystatin C); 0 (Enzymes); 0 (Hemoglobins); 0 (Leukocyte L1 Antigen Complex); 0 (Phosphates); 0 (Serum Albumin); 0 (Transferrins); 0 (Triglycerides); 268B43MJ25 (Uric Acid); 8W8T17847W (Urea); 9007-41-4 (C-Reactive Protein); AYI8EX34EU (Creatinine); E1UOL152H7 (Iron); I38ZP9992A (Magnesium); J41CSQ7QDS (Zinc); RFM9X3LJ49 (Bilirubin); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


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[PMID]:27108892
[Au] Autor:Yu AY; Lin CX; Wang QM; Zheng MQ; Qin XY
[Ad] Endereço:The Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. yaybetter@hotmail.com.
[Ti] Título:Safety of femtosecond laser-assisted cataract surgery: assessment of aqueous humour and lens capsule.
[So] Source:Acta Ophthalmol;94(7):e534-e540, 2016 Nov.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the effect of femtosecond laser-assisted cataract surgery (FLACS) on aqueous humour and lens capsule. METHODS: This prospective randomized comparative study enrolled 19 eyes that underwent FLACS as the trial group and 20 eyes that underwent conventional phacoemulsification as the control group. The femtosecond laser platform (LLS-fs 3D; LensAR, Orlando, FL, USA) was used to generate capsulotomy (laser energy 8 µJ) and lens fragmentation (laser energy 10 µJ). Morphology of the cutting edge and cells of anterior capsule was assessed by light microscopy. The proteins in the aqueous humour were identified by mass spectrometry (Ultraflex III TOF/TOF; Bruker Dalton, Bremen, Germany). Electrolyte in the aqueous humour was detected by a chemistry analyzer (Aeroset Clinical Chemistry Analyzer; Abbott Laboratories, Abbott Park, IL, USA). RESULTS: The cutting edge of anterior capsule was saw-tooth-shaped under magnification of 200× and 400× in the trial group, while it was smooth in the control group. Intact cells were found in the boundary area next to the cutting edge of anterior capsule in both groups. ß-Crystallin B1, γ-crystallin S and transferrin were detected in the aqueous humour in the trial group. The concentrations of K , Na and Cl in the aqueous humour in the trial group differed significantly from those in the control group (p = 0.02, 0.03 and 0.04, respectively). CONCLUSION: Femtosecond laser-assisted cataract surgery (FLACS) causes release of transferrin and crystallin from lens to aqueous humour and results in significant changes in the concentrations of K , Na and Cl in aqueous humour. However, these changes due to FLACS have no clinical significance or toxicity.
[Mh] Termos MeSH primário: Humor Aquoso/metabolismo
Extração de Catarata/efeitos adversos
Cristalinas/metabolismo
Terapia a Laser/efeitos adversos
Cápsula do Cristalino/patologia
Transferrinas/metabolismo
Equilíbrio Hidroeletrolítico/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Extração de Catarata/métodos
Cloretos/metabolismo
Eletroforese em Gel de Poliacrilamida
Feminino
Seres Humanos
Terapia a Laser/métodos
Masculino
Espectrometria de Massas
Meia-Idade
Potássio/metabolismo
Estudos Prospectivos
Sódio/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Chlorides); 0 (Crystallins); 0 (Transferrins); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170125
[Lr] Data última revisão:
170125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13022


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[PMID]:27043030
[Au] Autor:Lukaszyk E; Lukaszyk M; Koc-Zorawska E; Bodzenta-Lukaszyk A; Malyszko J
[Ad] Endereço:2nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Marii Sklodowskiej - Curie 24a, 15-276, Bialystok, Poland.
[Ti] Título:GDF-15, iron, and inflammation in early chronic kidney disease among elderly patients.
[So] Source:Int Urol Nephrol;48(6):839-44, 2016 Jun.
[Is] ISSN:1573-2584
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of the study was to assess GDF-15 and iron status in patients in early stages of chronic kidney disease with a particular emphasis on elderly population in association of classic iron status parameters with novel iron homeostasis biomarkers and inflammatory parameters. METHODS: Serum concentrations of GDF-15, iron (Fe), transferrin saturation, soluble transferrin receptor (sTfR), hepcidin, high-sensitive C-reactive protein (hsCRP), interleukin 6 (IL-6), and hemoglobin were measured in 56 patients ≥65 years of age and in 31 <65 years of age. RESULTS: In patients ≥65 years, serum concentrations of GDF-15 and hsCRP were significantly higher in comparison with younger group. There was no statistically significant difference in hemoglobin, iron, hepcidin, and sTfR concentration between the two studied groups. In both groups GDF-15 was significantly correlated with hemoglobin, eGFR, hsCRP, and IL-6. GDF-15 was significantly higher in patients with anemia in comparison with their non-anemic counterparts. In multivariate analysis, hemoglobin was found to be a predictor of log GDF-15 (beta value = 0.36, P = 0.006, R (2) = 37 %). CONCLUSIONS: An intricate interplay between renal function, anemia, and GDF-15 concentrations awaits further studies, as there are few data regarding pathophysiological role of GDF-15 in diabetes, kidney disease, and other comorbidities. Further understanding regarding the signaling pathways of GDF-15 may help to discover next pieces in the exciting puzzle of GDF-15. Finally, as studies dealing with normal level of GDF-15 in the healthy aged are lacking, it is possible that the higher values of GDF-15 values found in the present study represent values of GDF-15 according to age more than CKD levels.
[Mh] Termos MeSH primário: Fator 15 de Diferenciação de Crescimento/sangue
Ferro/sangue
Insuficiência Renal Crônica/sangue
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Proteína C-Reativa/metabolismo
Estudos de Casos e Controles
Feminino
Hemoglobinas/metabolismo
Hepcidinas/sangue
Seres Humanos
Inflamação
Interleucina-6/sangue
Masculino
Meia-Idade
Receptores da Transferrina/sangue
Transferrinas/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (GDF15 protein, human); 0 (Growth Differentiation Factor 15); 0 (Hemoglobins); 0 (Hepcidins); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (Receptors, Transferrin); 0 (Transferrins); 9007-41-4 (C-Reactive Protein); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1007/s11255-016-1278-z


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[PMID]:26975336
[Au] Autor:Wang X; Hodgkinson CP; Lu K; Payne AJ; Pratt RE; Dzau VJ
[Ad] Endereço:Mandel Center for Hypertension Research and Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
[Ti] Título:Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.
[So] Source:Sci Rep;6:23017, 2016 Mar 15.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have recently shown that a combination of microRNAs, miR combo, can directly reprogram cardiac fibroblasts into functional cardiomyocytes in vitro and in vivo. However, direct reprogramming strategies are inefficient and slow. Moving towards the eventual goal of clinical application it is necessary to develop new methodologies to overcome these limitations. Here, we report the identification of a specific media composition, reprogramming media (RM), which augmented the effect of miR combo by 5-15-fold depending upon the cardiac marker tested. RM alone was sufficient to strongly induce cardiac gene and protein expression in neonatal tail-tip as well as cardiac fibroblasts. Expression of pluripotency markers Nanog, Oct4, Sox2, and Klf4 was significantly enhanced by RM, with miR combo augmenting the effect further. Knockdown of Nanog by siRNA inhibited the effect of RM on cardiac gene expression. Removal of insulin-transferrin-selenium completely inhibited the effect of reprogramming media upon cardiac gene expression and the addition of selenium to standard culture media recapitulated the effects of RM. Moreover, selenium enhanced the reprogramming efficiency of miR combo.
[Mh] Termos MeSH primário: Reprogramação Celular/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
MicroRNAs/genética
Miócitos Cardíacos/efeitos dos fármacos
Proteína Homeobox Nanog/genética
Selênio/farmacologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Antioxidantes/farmacologia
Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/genética
Reprogramação Celular/genética
Meios de Cultura/química
Meios de Cultura/farmacologia
Fibroblastos/citologia
Fibroblastos/metabolismo
Expressão Gênica/efeitos dos fármacos
Insulina/farmacologia
Fatores de Transcrição Kruppel-Like/genética
Fatores de Transcrição Kruppel-Like/metabolismo
Camundongos Endogâmicos C57BL
Miócitos Cardíacos/citologia
Miócitos Cardíacos/metabolismo
Proteína Homeobox Nanog/metabolismo
Fator 3 de Transcrição de Octâmero/genética
Fator 3 de Transcrição de Octâmero/metabolismo
Interferência de RNA
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Fatores de Transcrição SOXB1/genética
Fatores de Transcrição SOXB1/metabolismo
Transferrinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Culture Media); 0 (GKLF protein); 0 (Insulin); 0 (Kruppel-Like Transcription Factors); 0 (MicroRNAs); 0 (Nanog Homeobox Protein); 0 (Octamer Transcription Factor-3); 0 (Pou5f1 protein, mouse); 0 (SOXB1 Transcription Factors); 0 (Sox2 protein, mouse); 0 (Transferrins); H6241UJ22B (Selenium)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE
[do] DOI:10.1038/srep23017


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[PMID]:26804249
[Au] Autor:Guardia Clausi M; Paez PM; Pasquini LA; Pasquini JM
[Ad] Endereço:Department of Biological Chemistry, School of Pharmacy and Biochemistry and IQUIFIB-CONICET, Universidad de Buenos Aires, Argentina; Department of Pharmacology, Physiology and Neuroscience, Rutgers-New Jersey Medical School, Newark, NJ, United States.
[Ti] Título:Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain.
[So] Source:Pharmacol Res;109:81-5, 2016 07.
[Is] ISSN:1096-1186
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hypoxic-ischemic brain damage is a major contributor to chronic neurological dysfunction and acute mortality in infants as well as in adults. In this review, we summarize recent publications demonstrating that the intranasal administration (INA) of apo-transferrin (aTf) and different growth factors provides neuroprotection to the mouse and rat brain after a hypoxic-ischemic event. The intranasal delivery of growth factors such as insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) has been found to improve neurological function and reduce infarct size in adult rats after a hypoxic-ischemic event. On the other hand, INA of aTf and epidermal growth factor (EGF) were effective in reducing white matter damage and inflammation and in promoting the proliferation and survival of oligodendroglial progenitor cells (OPCs) in a model of hypoxic-ischemic encephalopathy. Therefore, data summarized in this review suggest that INA of growth factors and aTf can be used in combination in clinical treatment in order to protect and repair the hypoxic-ischemic brain.
[Mh] Termos MeSH primário: Hipóxia-Isquemia Encefálica/tratamento farmacológico
Peptídeos e Proteínas de Sinalização Intercelular/administração & dosagem
Transferrinas/administração & dosagem
[Mh] Termos MeSH secundário: Administração Intranasal
Animais
Seres Humanos
Peptídeos e Proteínas de Sinalização Intercelular/uso terapêutico
Transferrinas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Intercellular Signaling Peptides and Proteins); 0 (Transferrins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE


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[PMID]:26471846
[Au] Autor:Ennis J; Gillen D; Rubenstein A; Worcester E; Brecher ME; Asplin J; Coe F
[Ad] Endereço:Litholink Corporation®, A LabCorp Company, Chicago, IL, USA. ennisj1@labcorp.com.
[Ti] Título:Clinical decision support improves physician guideline adherence for laboratory monitoring of chronic kidney disease: a matched cohort study.
[So] Source:BMC Nephrol;16:163, 2015 Oct 15.
[Is] ISSN:1471-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Guidelines exist for chronic kidney disease (CKD) but are not well implemented in clinical practice. We evaluated the impact of a guideline-based clinical decision support system (CDSS) on laboratory monitoring and achievement of laboratory targets in stage 3-4 CKD patients. METHODS: We performed a matched cohort study of 12,353 stage 3-4 CKD patients whose physicians opted to receive an automated guideline-based CDSS with CKD-related lab results, and 42,996 matched controls whose physicians did not receive the CDSS. Physicians were from US community-based physician practices utilizing a large, commercial laboratory (LabCorp®). We compared the percentage of laboratory tests obtained within guideline-recommended intervals and the percentage of results within guideline target ranges between CDSS and non-CDSS patients. Laboratory tests analyzed included estimated glomerular filtration rate, plasma parathyroid hormone, serum calcium, phosphorus, 25-hydroxy vitamin D (25-D), total carbon dioxide, transferrin saturation (TSAT), LDL cholesterol (LDL-C), blood hemoglobin, and urine protein measurements. RESULTS: Physicians who used the CDSS ordered all CKD-relevant testing more in accord with guidelines than those who did not use the system. Odds ratios favoring CDSS ranged from 1.29 (TSAT) to 1.88 (serum phosphorus) [CI, 1.20 to 2.01], p < 0.001 for all tests. The CDSS impact was greater for primary care physicians versus nephrologists. CDSS physicians met guideline targets for LDL-C and 25-D more often, but hemoglobin targets less often, than non-CDSS physicians. Use of CDSS did not impact guideline target achievement for the remaining tests. CONCLUSIONS: Use of an automated laboratory-based CDSS may improve physician adherence to guidelines with respect to timely monitoring of CKD.
[Mh] Termos MeSH primário: Sistemas de Apoio a Decisões Clínicas
Fidelidade a Diretrizes/estatística & dados numéricos
Testes de Função Renal/normas
Nefrologia/estatística & dados numéricos
Atenção Primária à Saúde/estatística & dados numéricos
Insuficiência Renal Crônica/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Cálcio/sangue
Dióxido de Carbono/sangue
Estudos de Casos e Controles
LDL-Colesterol/sangue
Feminino
Taxa de Filtração Glomerular
Hemoglobinas/metabolismo
Seres Humanos
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Fósforo/sangue
Guias de Prática Clínica como Assunto
Proteinúria/urina
Sistemas de Alerta
Insuficiência Renal Crônica/sangue
Transferrinas/sangue
Vitamina D/análogos & derivados
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholesterol, LDL); 0 (Hemoglobins); 0 (Parathyroid Hormone); 0 (Transferrins); 1406-16-2 (Vitamin D); 142M471B3J (Carbon Dioxide); 27YLU75U4W (Phosphorus); 64719-49-9 (25-hydroxyvitamin D); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151017
[St] Status:MEDLINE
[do] DOI:10.1186/s12882-015-0159-5


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[PMID]:26241638
[Au] Autor:Roghi A; Poggiali E; Duca L; Mafrici A; Pedrotti P; Paccagnini S; Brenna S; Galli A; Consonni D; Cappellini MD
[Ad] Endereço:CMR Unit, Department of Cardiology and Cardiovascular Surgery, Niguarda Ca'Granda Hospital, Milan, Italy. Electronic address: alberto.roghi@gmail.com.
[Ti] Título:Role of Non-Transferrin-Bound Iron in the pathogenesis of cardiotoxicity in patients with ST-elevation myocardial infarction assessed by Cardiac Magnetic Resonance Imaging.
[So] Source:Int J Cardiol;199:326-32, 2015 Nov 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hereditary hemochromatosis, thalassemia and myelodysplastic syndromes represent disease models with evidence of iron-related heart failure. Non-Transferrin Bound Iron (NTBI) induces cardiac toxicity through the production of reactive oxygen species and lipid peroxidation. In ST-elevation acute myocardial infarction (STEMI) with evidence of microvascular obstruction (MVO) and hemorrhage (HEM), HEM may be a source of iron-related cardiac toxicity through NTBI and pro-inflammatory mediators. AIM OF THE STUDY: The study aims to assess NTBI in patients with STEMI and its possible relationship with MVO and HEM. METHODS AND RESULTS: NTBI, LPO-Malondialdehyde (MDA) and interleukin-6 (IL-6) were assessed in 15 patients with STEMI immediately before primary percutaneous coronary intervention (PPCI) and at 3, 6, 9, 12, and 24h post-PPCI. Cardiac Magnetic Resonance (CMR) was performed at 5days and 6months after STEMI. Myocardial edema and HEM were assessed by T2 and T2* mapping. MVO and necrotic area were assessed by early and late gadolinium enhancement (LGE). NTBI was detected in 13/15 patients with the highest values in 4 patients with evidence of MVO and HEM. NTBI levels were significantly related to CK-MB and troponin T values. NTBI kinetics appeared to be different in patients with MVO and HEM (7/15 patients), with a peak value at 6h after PCI, in comparison with those with no evidence of MVO and HEM, in whom NTBI values were lower and remained indeterminable after the first 24h. CONCLUSIONS: The detection of elevated NTBI values in patients with STEMI, MVO and HEM suggests a possible role of iron cardiotoxicity in myocardial damage.
[Mh] Termos MeSH primário: Ferro/metabolismo
Imagem por Ressonância Magnética/métodos
Infarto do Miocárdio/metabolismo
Transferrinas/metabolismo
[Mh] Termos MeSH secundário: Creatina Quinase Forma MB/metabolismo
Feminino
Hemorragia/metabolismo
Seres Humanos
Interleucina-6/metabolismo
Ferro/sangue
Masculino
Malondialdeído/metabolismo
Microcirculação/fisiologia
Microvasos/patologia
Meia-Idade
Infarto do Miocárdio/sangue
Infarto do Miocárdio/patologia
Infarto do Miocárdio/terapia
Miocardite/metabolismo
Miocardite/patologia
Miocárdio/metabolismo
Miocárdio/patologia
Intervenção Coronária Percutânea
Estudos Prospectivos
Traumatismo por Reperfusão/fisiopatologia
Transferrinas/sangue
Troponina T/sangue
Troponina T/metabolismo
Remodelação Ventricular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL6 protein, human); 0 (Interleukin-6); 0 (Transferrins); 0 (Troponin T); 4Y8F71G49Q (Malondialdehyde); E1UOL152H7 (Iron); EC 2.7.3.2 (Creatine Kinase, MB Form)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150915
[Lr] Data última revisão:
150915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150805
[St] Status:MEDLINE



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