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  1 / 9 MEDLINE  
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[PMID]:28456765
[Au] Autor:Knapp M; Gorski J
[Ad] Endereço:Department of Cardiology, Medical University of Bialystok, Bialystok, Poland. malgo33@interia.pl.
[Ti] Título:The skeletal and heart muscle triacylglycerol lipolysis revisited.
[So] Source:J Physiol Pharmacol;68(1):3-11, 2017 Feb.
[Is] ISSN:1899-1505
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:For 40 years, the enzyme hormone sensitive lipase was considered to hydrolyze the first ester bond of the triacylglycerol moiety and thus initiate hydrolysis. However, 12 years ago a new lipolytic enzyme, termed adipose triglyceride lipase was discovered. It was further shown that the process of lipolysis of triacylglycerol to diacylglycerol and fatty acid is initiated by adipose triglyceride lipase and not by hormone sensitive lipase, responsible for hydrolysis of diacylglycerol to monoacyglycerol and fatty acid. Adipose triglyceride lipase is present in all types of cells containing neutral fat. The enzyme is activated by a protein called comparative gene identification-58 and inhibited by a protein called G0/G1 switch protein 2. It has also been discovered that perilipins, the main proteins coating lipid droplets in the cells, are involved in the process of triacylglycerol lipolysis. Five perilipins (1-5) were identified, however, up to now their role has been poorly assessed. In skeletal muscles, exercise and training affect the mRNA expression and protein content of adipose triglyceride lipase, comparative gene identification-58, G0/G1 switch protein 2, perilipin 2 and 5. The effect of exercise/training depends on exercise intensity and type of muscle fiber. An interaction between comparative gene identification-58 and adipose triglyceride lipase seems to be responsible for the enzyme activation during contractile activity. Adipose triglyceride lipase is also responsible for the activation of the first step of triacylglycerol lipolysis in the heart. There is substantial evidence that cardiac triacylglycerol metabolism affects the function of the heart. ATGL gene mutations leads to the development of neutral lipid storage diseases.
[Mh] Termos MeSH primário: Músculo Esquelético/metabolismo
Miocárdio/metabolismo
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Seres Humanos
Hidrólise
Lipólise
Perilipinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Perilipins); 0 (Triglycerides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:28454542
[Au] Autor:Itabe H; Yamaguchi T; Nimura S; Sasabe N
[Ad] Endereço:Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan. h-itabe@pharm.showa-u.ac.jp.
[Ti] Título:Perilipins: a diversity of intracellular lipid droplet proteins.
[So] Source:Lipids Health Dis;16(1):83, 2017 Apr 28.
[Is] ISSN:1476-511X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they are active sites of neutral lipid metabolism, and comprise neutral lipid or cholesterol cores surrounded by phospholipid monolayers containing specialized proteins. However, sizes and protein compositions vary between cell and tissue types. Proteins of the perilipin family have been associated with surfaces of LDs and all carry a conserved 11-mer repeat motif. Accumulating evidence indicates that all perilipins are involved in LD formation and that all play roles in LD function under differing conditions. In this brief review, we summarize current knowledge of the roles of perilipins and lipid metabolizing enzymes in a variety of mammalian cell types.
[Mh] Termos MeSH primário: Adipócitos/metabolismo
Hidroxiesteroide Desidrogenases/genética
Gotículas Lipídicas/metabolismo
Metabolismo dos Lipídeos/genética
Perilipinas/genética
[Mh] Termos MeSH secundário: Animais
Colesterol/metabolismo
Retículo Endoplasmático/metabolismo
Regulação da Expressão Gênica
Seres Humanos
Hidroxiesteroide Desidrogenases/metabolismo
Mitocôndrias/metabolismo
Perilipinas/química
Perilipinas/classificação
Perilipinas/metabolismo
Domínios Proteicos
Transdução de Sinais
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Perilipins); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol); EC 1.1.- (Hydroxysteroid Dehydrogenases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s12944-017-0473-y


  3 / 9 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:29236794
[Au] Autor:Arruda EGP; Munhoz AM; Matsumoto W; Ueda T; Coudry RA; Gemperli R
[Ad] Endereço:Assistant Professor, Plastic Surgery Division, Department of Surgery, School of Medicine, Universidade de São Paulo (USP), Brazil. Conception and design of the study, acquisition and interpretation of data.
[Ti] Título:Qualitative analysis of the viability of autogenous fat grafts grafted in different environments of interstitial pressure. Preliminary results and description of a new experimental model in mini-pigs.
[So] Source:Acta Cir Bras;32(11):891-902, 2017 Nov.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. METHODS: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure "under tension". A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP. RESULTS: The mean operative time was 236 min (210 - 272 min). All the AFG and muscular segments were removed successfully. Average interstitial pressure CP and H were 3 and 10.6 mmHg respectively. The AFG were biopsied for histopathological analysis 30 days after graft. Hematoxylin-eosin staining and immunohistochemical analyzes (TNF-alpha, CD31 and Perilipine with monoclonal antibodies) were employed. CONCLUSION: The data show that minipigs model could be used as a recipient site for autologous fat graft techniques and allow the development of studies to explore the AFG intake and pathophysiology response.
[Mh] Termos MeSH primário: Tecido Adiposo/transplante
Modelos Animais de Doenças
Procedimentos Cirúrgicos Reconstrutivos/métodos
Transplante Autólogo/métodos
[Mh] Termos MeSH secundário: Animais
Estudos de Viabilidade
Sobrevivência de Enxerto
Imuno-Histoquímica
Masculino
Perilipinas/análise
Molécula-1 de Adesão Celular Endotelial de Plaquetas/análise
Pressão
Procedimentos Cirúrgicos Reconstrutivos/normas
Suínos
Porco Miniatura
Transplante Autólogo/normas
Fator de Necrose Tumoral alfa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Perilipins); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


  4 / 9 MEDLINE  
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[PMID]:29024632
[Au] Autor:Zheng X; Ning C; Dong Y; Zhao P; Li J; Fan Z; Li J; Yu Y; Mrode R; Liu JF
[Ad] Endereço:National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
[Ti] Título:Quantitative proteome analysis of bovine mammary gland reveals protein dynamic changes involved in peak and late lactation stages.
[So] Source:Biochem Biophys Res Commun;494(1-2):292-297, 2017 Dec 09.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mammary gland is an important organ for milk synthesis and secretion. It undergoes dramatic physiological changes to adapt the shift from peak to late lactation stage. Protein plays a final very vital role in many life functions, and the protein changes during different lactation stages potentially reflect the biology of lactation and the functions of mammary gland in cows. In current study, we adopted tandem mass tags label-based quantitative analysis technique and to investigate proteome changes occurring in bovine mammary gland from peak to late lactation stages. A total of 3753 proteins from mammary tissues taken at two lactation points from four individual cows by biopsy were quantified, out of which 179 proteins were expressed differentially between two stages. We observed five new DEPs (AACS, DHCR7, GSTM3, SFRP1 and SFRP4) and nine functional well-studies known proteins (PLIN2, LPIN1, PLIN3, GSN, CD74, MMP2, SOD1, SOD3 and GPX3) related to milk performance and mammary morphology. Bioinformatics analyses of the DEPs showed a majority of the up-regulated proteins during late lactation stage were related to apoptosis and immune process, while the downregulated proteins were mainly involved in localization, lipid metabolic and transport process. This suggests that the mammary gland can adapt to different molecular functions according to the biological need of the animal. From the integrated analysis of the differentially expressed proteins with known quantitative trait loci and genome-wide association study data, we identified 95 proteins may potentially affect milking performance. We expect findings in this study could be a valuable resource for future studies investigating the bovine proteome and functional studies.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica no Desenvolvimento
Lactação/genética
Glândulas Mamárias Animais/metabolismo
Proteoma/genética
Locos de Características Quantitativas
[Mh] Termos MeSH secundário: Animais
Apoptose
Bovinos
Feminino
Ontologia Genética
Glutationa Transferase/genética
Glutationa Transferase/imunologia
Imunidade Inata
Isoenzimas/genética
Isoenzimas/imunologia
Glândulas Mamárias Animais/crescimento & desenvolvimento
Metaloproteinase 2 da Matriz/genética
Metaloproteinase 2 da Matriz/imunologia
Anotação de Sequência Molecular
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/genética
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/imunologia
Perilipinas/genética
Perilipinas/imunologia
Proteoma/imunologia
Proteômica
Superóxido Dismutase/genética
Superóxido Dismutase/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoenzymes); 0 (Perilipins); 0 (Proteome); EC 1.15.1.1 (Superoxide Dismutase); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.1.21 (7-dehydrocholesterol reductase); EC 2.5.1.18 (Glutathione Transferase); EC 2.5.1.18 (glutathione transferase M3-3); EC 3.4.24.24 (Matrix Metalloproteinase 2)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE


  5 / 9 MEDLINE  
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[PMID]:28551069
[Au] Autor:Dany M; Elston D
[Ad] Endereço:Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina.
[Ti] Título:Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa.
[So] Source:J Am Acad Dermatol;77(2):268-273.e6, 2017 Aug.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hidradenitis suppurativa (HS) is a debilitating skin disease characterized by painful recurrent nodules and abscesses caused by chronic inflammation. Early events in the development of HS are believed to occur in the folliculopilosebaceous unit; however, the signaling pathways behind this mechanism are unknown. Sphingolipids, such as ceramide, are essential components of the skin and appendages and have important structural and signaling roles. OBJECTIVE: We sought to explore whether the gene expression of enzymes involved in sphingolipid metabolic pathways is altered in HS. METHODS: A microarray data set including 30 samples was used to compare the expression of sphingolipid-related enzymes in inflammatory skin lesions from HS patients (n = 17) with the expression in clinically healthy skin tissue (n = 13). Differential expression of sphingolipid metabolism-related genes was analyzed using Gene Expression Omnibus 2R. RESULTS: HS lesional skin samples have significantly decreased expression of enzymes generating ceramide and sphingomyelin, increased expression of enzymes catabolizing ceramide to sphingosine, and increased expression of enzymes converting ceramide to galactosylceramide and gangliosides. LIMITATIONS: Limitations of this study include assessing the expression of sphingolipid-related enzymes without assessing the levels of the related sphingolipids. CONCLUSION: Our study suggests that sphingolipid metabolism is altered in HS lesional skin compared with normal skin.
[Mh] Termos MeSH primário: Expressão Gênica
Hidradenite Supurativa/enzimologia
Hidradenite Supurativa/genética
Perilipinas/genética
Pele/enzimologia
Esfingolipídeos/metabolismo
[Mh] Termos MeSH secundário: Ceramidase Alcalina/genética
Estudos de Casos e Controles
Ceramidas/metabolismo
Proteínas Quinases Dependentes de AMP Cíclico/genética
Glucosilceramidase/genética
Glucosiltransferases/genética
Glicoesfingolipídeos/metabolismo
Hexosaminidases/genética
Seres Humanos
Lisofosfolipídeos/metabolismo
Proteínas de Membrana/genética
Redes e Vias Metabólicas/genética
Fosfotransferases (Aceptor do Grupo Álcool)/genética
Serina C-Palmitoiltransferase/genética
Transdução de Sinais/genética
Esfingolipídeos/biossíntese
Esfingomielina Fosfodiesterase/genética
Esfingomielinas/metabolismo
Esfingosina/análogos & derivados
Esfingosina/metabolismo
Esfingosina N-Aciltransferase/genética
Proteínas Supressoras de Tumor/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ceramides); 0 (Glycosphingolipids); 0 (Lysophospholipids); 0 (Membrane Proteins); 0 (Perilipins); 0 (Sphingolipids); 0 (Sphingomyelins); 0 (Tumor Suppressor Proteins); 26993-30-6 (sphingosine 1-phosphate); EC 2.3.1.24 (CERS2 protein, human); EC 2.3.1.24 (CERS5 protein, human); EC 2.3.1.24 (Sphingosine N-Acyltransferase); EC 2.3.1.50 (Serine C-Palmitoyltransferase); EC 2.4.1.- (Glucosyltransferases); EC 2.4.1.80 (ceramide glucosyltransferase); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.91 (sphingosine kinase 2, human); EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases); EC 3.1.4.12 (Sphingomyelin Phosphodiesterase); EC 3.2.1.- (Hexosaminidases); EC 3.2.1.45 (Glucosylceramidase); EC 3.5.1.23 (Alkaline Ceramidase); NGZ37HRE42 (Sphingosine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


  6 / 9 MEDLINE  
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[PMID]:28476896
[Au] Autor:Goetzl EJ; Schwartz JB; Mustapic M; Lobach IV; Daneman R; Abner EL; Jicha GA
[Ad] Endereço:Department of Medicine, University of California, San Francisco, San Francisco, California, USA; edward.goetzl@ucsf.edu.
[Ti] Título:Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.
[So] Source:FASEB J;31(8):3689-3694, 2017 Aug.
[Is] ISSN:1530-6860
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plasma endothelial cell-derived exosomes (EDEs) and platelet-derived exosomes (PDEs) were precipitated and enriched separately by immunospecific absorption procedures for analyses of cargo proteins relevant to atherosclerosis. EDEs had usual exosome size and marker protein content, and significantly higher levels than PDEs of the endothelial proteins vascular cell adhesion molecule-1 (VCAM-1) and endothelial nitric oxide synthase, whereas PDEs had significantly higher levels of platelet glycoprotein VI. EDE levels of VCAM-1, von Willebrand factor, platelet-derived growth factor (PDGF)-BB, angiopoietin-1, and lysyl oxidase-2 and the cerebrovascular-selective proteins glucose transporter 1, permeability-glycoprotein, and large neutral amino acid transporter 1 were significantly higher for 18 patients with cerebrovascular disease (CeVD) than for 18 age- and gender-matched control subjects. PDE levels of PDGF-AA, platelet glycoprotein VI, integrin-linked kinase-1, high mobility group box-1 protein, chemokine CXCL4, and thrombospondin-1 were significantly higher in patients with CeVD than in control subjects, but differences were less with greater overlaps than for EDE proteins. EDE levels of Yes-associated protein (YAP) were higher and of P(S127)-YAP lower in patients with CeVD than in control subjects, consistent with heightened activity of this mechanical force-sensitive system in atherosclerosis. Elevated EDE and PDE levels of atherosclerosis-promoting proteins in CeVD justify clinical studies of their potential value as biomarkers.-Goetzl, E. J., Schwartz, J. B., Mustapic, M., Lobach, I. V., Daneman, R., Abner, E. L., Jicha, G. A. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.
[Mh] Termos MeSH primário: Aterosclerose/metabolismo
Plaquetas/fisiologia
Proteínas de Transporte/metabolismo
Transtornos Cerebrovasculares/metabolismo
Células Endoteliais/fisiologia
Exossomos/fisiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Regulação da Expressão Gênica/fisiologia
Seres Humanos
Masculino
Perilipinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Perilipins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1096/fj.201700149


  7 / 9 MEDLINE  
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[PMID]:27822589
[Au] Autor:Suzuki M
[Ad] Endereço:Department of Molecular Genetics and Microbiology, Duke University, 272 Jones Building Box 3580, DUMC, Durham, NC, 27710, USA. michitaka.suzuki@duke.edu.
[Ti] Título:Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets.
[So] Source:Anat Sci Int;92(1):50-54, 2017 Jan.
[Is] ISSN:1447-073X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids to regulate cellular lipid homeostasis. Fatty acids are packaged as triglyceride and cholesterol ester into endoplasmic reticulum (ER) membranes to synthesize LDs. Cytosolic LDs move dynamically and interact with organelles, including other LDs. In this process, functional proteins for metabolism are also transferred to LDs. In this review, I focus on interactions between the ER and LDs related to lipid metabolism.
[Mh] Termos MeSH primário: Retículo Endoplasmático/metabolismo
Gotículas Lipídicas/metabolismo
Metabolismo dos Lipídeos
[Mh] Termos MeSH secundário: Retículo Endoplasmático/fisiologia
Seres Humanos
Gotículas Lipídicas/fisiologia
Lipólise
Membranas Mitocondriais/metabolismo
Organelas
Perilipina-1/metabolismo
Perilipina-1/fisiologia
Perilipinas/metabolismo
Perilipinas/fisiologia
Fosfatidilcolinas/biossíntese
Ligação Proteica
Proteólise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (PLIN1 protein, human); 0 (Perilipin-1); 0 (Perilipins); 0 (Phosphatidylcholines)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


  8 / 9 MEDLINE  
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[PMID]:27431369
[Au] Autor:Kimmel AR; Sztalryd C
[Ad] Endereço:Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, Maryland 20892; email: alank@helix.nih.gov.
[Ti] Título:The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis.
[So] Source:Annu Rev Nutr;36:471-509, 2016 Jul 17.
[Is] ISSN:1545-4312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in the understanding of lipolytic regulation. Focus then shifted from the enzymatic activation of lipases to substrate accessibility, mediated by perilipin-dependent protein sequestration and recruitment. Consequently, the lipid droplet became recognized as a unique, metabolically active cellular organelle and its surface as the active site for novel protein-protein interactions. A new area of investigation emerged, centered on lipid droplets' biology and their role in energy homeostasis. The perilipin family is of ancient origin and has expanded to include five mammalian genes and a growing list of evolutionarily conserved members. Universally, the perilipins modulate cellular lipid storage. This review provides a summary that connects the perilipins to both cellular and whole-body homeostasis.
[Mh] Termos MeSH primário: Tecido Adiposo Branco/metabolismo
Metabolismo Energético
Homeostase
Gotículas Lipídicas/metabolismo
Modelos Biológicos
Perilipinas/metabolismo
Processamento de Proteína Pós-Traducional
[Mh] Termos MeSH secundário: Tecido Adiposo Branco/citologia
Tecido Adiposo Branco/imunologia
Tecido Adiposo Branco/patologia
Animais
Diabetes Mellitus Tipo 2/imunologia
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/patologia
Gorduras na Dieta/metabolismo
Regulação da Expressão Gênica
Seres Humanos
Ligantes
Lipólise
Hepatopatia Gordurosa não Alcoólica/imunologia
Hepatopatia Gordurosa não Alcoólica/metabolismo
Hepatopatia Gordurosa não Alcoólica/patologia
Especificidade de Órgãos
Paniculite/imunologia
Paniculite/metabolismo
Paniculite/patologia
Perilipinas/química
Perilipinas/genética
Receptores Ativados por Proliferador de Peroxissomo/metabolismo
Fosforilação
Isoformas de Proteínas/química
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Ligands); 0 (Perilipins); 0 (Peroxisome Proliferator-Activated Receptors); 0 (Protein Isoforms)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-nutr-071813-105410


  9 / 9 MEDLINE  
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[PMID]:27427910
[Au] Autor:Kehrer J; Singer M; Lemgruber L; Silva PA; Frischknecht F; Mair GR
[Ad] Endereço:Integrative Parasitology, Center for Infectious Diseases, University of Heidelberg Medical School, Heidelberg, Germany.
[Ti] Título:A Putative Small Solute Transporter Is Responsible for the Secretion of G377 and TRAP-Containing Secretory Vesicles during Plasmodium Gamete Egress and Sporozoite Motility.
[So] Source:PLoS Pathog;12(7):e1005734, 2016 Jul.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Regulated protein secretion is required for malaria parasite life cycle progression and transmission between the mammalian host and mosquito vector. During transmission from the host to the vector, exocytosis of highly specialised secretory vesicles, such as osmiophilic bodies, is key to the dissolution of the red blood cell and parasitophorous vacuole membranes enabling gamete egress. The positioning of adhesins from the TRAP family, from micronemes to the sporozoite surface, is essential for gliding motility of the parasite and transmission from mosquito to mammalian host. Here we identify a conserved role for the putative pantothenate transporter PAT in Plasmodium berghei in vesicle fusion of two distinct classes of vesicles in gametocytes and sporozoites. PAT is a membrane component of osmiophilic bodies in gametocytes and micronemes in sporozoites. Despite normal formation and trafficking of osmiophilic bodies to the cell surface upon activation, PAT-deficient gametes fail to discharge their contents, remain intraerythrocytic and unavailable for fertilisation and further development in the mosquito. Sporozoites lacking PAT fail to secrete TRAP, are immotile and thus unable to infect the subsequent rodent host. Thus, P. berghei PAT appears to regulate exocytosis in two distinct populations of vesicles in two different life cycle forms rather than acting as pantothenic transporter during parasite transmission.
[Mh] Termos MeSH primário: Anopheles/parasitologia
Malária/transmissão
Perilipinas/metabolismo
Plasmodium berghei/metabolismo
Proteínas de Protozoários/metabolismo
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Exocitose/fisiologia
Imunofluorescência
Técnicas de Silenciamento de Genes
Insetos Vetores/parasitologia
Camundongos
Microscopia Eletrônica
Vesículas Secretórias/metabolismo
Esporozoítos/metabolismo
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Perilipins); 0 (Protozoan Proteins); 120300-02-9 (thrombospondin-related adhesive protein, protozoan)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1005734



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