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[PMID]: | 29172481 |
[Au] Autor: | Rebello CJ; Greenway FL; Johnson WD; Ribnicky D; Poulev A; Stadler K; Coulter AA |
[Ad] Endereço: | Pennington Biomedical Research Center , 6400 Perkins Road, Baton Rouge, Louisiana 70808, United States. |
[Ti] Título: | Fucoxanthin and Its Metabolite Fucoxanthinol Do Not Induce Browning in Human Adipocytes. |
[So] Source: | J Agric Food Chem;65(50):10915-10924, 2017 Dec 20. | [Is] ISSN: | 1520-5118 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Rodent studies suggest that the antiobesity effects of fucoxanthin relate to activation of brown fat and conversion of white adipocytes to the brown phenotype. To evaluate the browning effect in human adipocytes, we investigated the genes involved in browning and measured the oxygen consumption rate (OCR). Data were analyzed by one way ANOVA. Relative to control, fucoxanthinol (1 µM, 0.1 µM, 0.01 µM, 1 nM, 0.1 nM), the metabolite present in human plasma, stimulated lipolysis acutely (mean ± SEM: 4.2 ± 0.8, 3.1 ± 0.6, 4.1 ± 0.9, 3.8 ± 0.7, 3.8 ± 0.7, respectively, p < 0.01). There was no effect on OCR or the mRNA expression of UCP1, CPT-1ß, and GLUT4, the genes associated with browning of adipose tissue, when human adipocytes were treated with fucoxanthin or fucoxanthinol. -mRNA expression of PGC-1α, PPARα, PPARγ, PDK4, FAS, and the lipolytic enzymes was not significantly altered by fucoxanthinol treatment (p > 0.05). Thus, in human adipocytes, fucoxanthin and its metabolite do not stimulate conversion of white adipocytes to the brown phenotype. |
[Mh] Termos MeSH primário: |
Xantofilas/metabolismo beta Caroteno/análogos & derivados
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[Mh] Termos MeSH secundário: |
Adipócitos/efeitos dos fármacos Adipócitos/metabolismo Tecido Adiposo Marrom/citologia Tecido Adiposo Marrom/efeitos dos fármacos Tecido Adiposo Marrom/metabolismo Transportador de Glucose Tipo 4/genética Transportador de Glucose Tipo 4/metabolismo Seres Humanos Lipólise/efeitos dos fármacos PPAR gama/genética PPAR gama/metabolismo Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo Proteína Desacopladora 1/genética Proteína Desacopladora 1/metabolismo Xantofilas/farmacologia beta Caroteno/metabolismo beta Caroteno/farmacologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Glucose Transporter Type 4); 0 (PPAR gamma); 0 (PPARGC1A protein, human); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (SLC2A4 protein, human); 0 (UCP1 protein, human); 0 (Uncoupling Protein 1); 0 (Xanthophylls); 01YAE03M7J (beta Carotene); 06O0TC0VSM (fucoxanthin); 7176-02-5 (fucoxanthinol) |
[Em] Mês de entrada: | 1801 |
[Cu] Atualização por classe: | 180210 |
[Lr] Data última revisão:
| 180210 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 171128 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1021/acs.jafc.7b03931 |
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