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Suzuki, Akemi
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[PMID]:27773703
[Au] Autor:Hirano M; Totani K; Fukuda T; Gu J; Suzuki A
[Ad] Endereço:Institute of Glycoscience, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan; Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1 Kichijoji-kita, Musashino, Tokyo 180-8633, Japan. Electronic address: mhirano@st.seikei.ac.jp.
[Ti] Título:N-Glycoform-dependent interactions of megalin with its ligands.
[So] Source:Biochim Biophys Acta;1861(1 Pt A):3106-3118, 2017 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Megalin is a 600-kDa single-spanning transmembrane glycoprotein and functions as an endocytic receptor, distributed not only in the kidney but also in other tissues. Structurally and functionally distinct ligands for megalin have been identified. Megalin has 30 potential N-glycosylation sites in its extracellular domain. We found that megalin interacts with its ligands in a glycoform-dependent manner. METHODS: Distribution of megalin and glycans was histochemically analyzed in mouse kidneys. Kidney absorption of Cy5-labeled ligands was examined in vivo. Megalin-ligand interactions were analyzed using ligand blotting and ELISA. RESULTS: Megalins expressed on renal proximal convoluted tubules (PCTs) and proximal straight tubules (PSTs) have different N-glycans. PCT megalin stained with Lens culinaris agglutinin (LCA), which recognizes core-fucosyl N-glycans catalyzed by α1,6-fucosyltransferase (Fut8). In contrast, PST megalin stained with wheat germ agglutinin (WGA), which recognizes hybrid-type N-glycans. Retinol-binding protein-Cy5 (RBP-Cy5) was endocytosed by megalin on PCTs but minimally endocytosed by PSTs. BSA-Cy5 was endocytosed nearly equally by both tubules. The purified LCA-positive glycoform megalin had higher binding activity for RBP and vitamin D-binding protein than did WGA-positive glycoform megalin. Both glycoforms had nearly the same BSA- and kanamycin-binding activities. RBP-binding analysis of megalin lacking core fucose, in Fut8 mouse kidneys, had significantly decreased binding activity. CONCLUSIONS: N-Glycosylation of megalin can modulate its ligand-binding activity. Core fucosylation, in particular, is a modification crucial for megalin-RBP interactions. GENERAL SIGNIFICANCE: Cell type-specific glycoforms of megalin exist in the proximal tubular cells and modulate ligand absorption capacity.
[Mh] Termos MeSH primário: Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo
Polissacarídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Carbocianinas/metabolismo
Cromatografia de Afinidade
Feminino
Fucosiltransferases/deficiência
Fucosiltransferases/metabolismo
Glicosilação
Rim/metabolismo
Túbulos Renais Proximais/citologia
Túbulos Renais Proximais/metabolismo
Ligantes
Camundongos Endogâmicos C57BL
Camundongos Knockout
Especificidade de Órgãos
Lectinas de Plantas/metabolismo
Ligação Proteica
Proteínas de Ligação ao Retinol/metabolismo
Aglutininas do Germe de Trigo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbocyanines); 0 (Ligands); 0 (Low Density Lipoprotein Receptor-Related Protein-2); 0 (Plant Lectins); 0 (Polysaccharides); 0 (Retinol-Binding Proteins); 0 (Wheat Germ Agglutinins); 0 (cyanine dye 5); 0 (lentil lectin); EC 2.4.1.- (Fucosyltransferases); EC 2.4.1.68 (Glycoprotein 6-alpha-L-fucosyltransferase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:29189196
[Au] Autor:Diana A; Haszard JJ; Purnamasari DM; Nurulazmi I; Luftimas DE; Rahmania S; Nugraha GI; Erhardt J; Gibson RS; Houghton L
[Ad] Endereço:1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia.
[Ti] Título:Iron, zinc, vitamin A and selenium status in a cohort of Indonesian infants after adjusting for inflammation using several different approaches.
[So] Source:Br J Nutr;118(10):830-839, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inflammation confounds the interpretation of several micronutrient biomarkers resulting in estimates that may not reflect the true burden of deficiency. We aimed to assess and compare the micronutrient status of a cohort of Indonesian infants (n 230) at aged 6, 9 and 12 months by ignoring inflammation (unadjusted) and adjusting four micronutrient biomarkers for inflammation with C-reactive protein (CRP) and α-1-glycoprotein (AGP) using the following methods: (1) arithmetic correction factors with the use of a four-stage inflammation model; and (2) regression modelling. Prevalence of infants with any inflammation (CRP>5 mg/l and/or AGP>1 g/l) was about 25% at each age. Compared with unadjusted values, regression adjustment at 6, 9 and 12 months generated the lowest (P50 % across all ages. In conclusion, without inflammation adjustment, Fe deficiency was grossly under-estimated and vitamin A and Zn deficiency over-estimated, highlighting the importance of correcting for the influence of such, before implementing programmes to alleviate micronutrient malnutrition. However, further work is needed to validate the proposed approaches with a particular focus on assessing the influence of varying degrees of inflammation (i.e. recurrent acute infections and low-grade chronic inflammation) on each affected nutrient biomarker.
[Mh] Termos MeSH primário: Deficiências Nutricionais/sangue
Inflamação/sangue
Ferro/sangue
Estado Nutricional
Selênio/sangue
Vitamina A/sangue
Zinco/sangue
[Mh] Termos MeSH secundário: Anemia Ferropriva/sangue
Anemia Ferropriva/epidemiologia
Biomarcadores/sangue
Proteína C-Reativa/metabolismo
Estudos de Coortes
Estudos Transversais
Deficiências Nutricionais/epidemiologia
Feminino
Ferritinas/sangue
Seres Humanos
Indonésia/epidemiologia
Lactente
Inflamação/complicações
Inflamação/epidemiologia
Ferro/deficiência
Masculino
Micronutrientes/sangue
Orosomucoide/metabolismo
Prevalência
Proteínas de Ligação ao Retinol/metabolismo
Selênio/deficiência
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/epidemiologia
Zinco/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002860


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[PMID]:28954270
[Au] Autor:Wu J; Shao X; Lu K; Zhou J; Ren M; Xie X; Liu J; Xu Y; Ding Y; Shen X; Zhu C
[Ti] Título:Urinary RBP and NGAL Levels are Associated with Nephropathy in Patients with Type 2 Diabetes.
[So] Source:Cell Physiol Biochem;42(2):594-602, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: The diagnosis of type 2 diabetic nephropathy (T2DN) patients is important to prevent the long-term damaging effects of kidney loss in patients with diabetes and is decisive for patient outcomes. The aim of this study was to explore urine retinol binding protein (RBP) and neutrophil gelatinase-associated lipocalin (NGAL) in T2DN patients with and without albuminuria. METHODS: A total of 293 T2DN patients were divided into three groups according to their urine albumin/urine creatinine ratio (UACR): normoalbuminuria group (UACR<30 mg/g, n=100), microalbuminuria group (UACR 30-300 mg/g, n=100) and macroalbuminuria group (UACR>300 mg/g, n=93); 50 non-diabetic subjects were recruited as the control group. The levels of urine RBP, NGAL, TNF-α and IL-18 in T2DN patients and non-diabetic subjects were measured using ELISA assays. RESULTS: We first analyzed the clinical characteristics of the control and T2DN groups and found that urine NGAL, RBP, TNF-α and IL-18 levels were significantly increased and significantly correlated with the degree of albuminuria. In addition, univariate linear regression analysis showed that urine RBP was associated with UACR, BMI, Scr, BUN, TG, disease duration, SBP, NGAL, TNF-α and IL-18 levels, and urine NGAL was positively correlated with UACR, Scr, BUN, RBP, TNF-α and IL-18 levels. CONCLUSION: The results indicate that urine levels of NGAL and RBP may be independently associated with albuminuria in T2DN and may serve as novel biomarkers for the identification of T2DN.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/urina
Nefropatias Diabéticas/complicações
Nefropatias Diabéticas/urina
Lipocalina-2/urina
Proteínas de Ligação ao Retinol/urina
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Albuminúria/complicações
Albuminúria/urina
Biomarcadores/urina
Nefropatias Diabéticas/diagnóstico
Feminino
Seres Humanos
Interleucina-18/urina
Masculino
Meia-Idade
Fator de Necrose Tumoral alfa/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Interleukin-18); 0 (LCN2 protein, human); 0 (Lipocalin-2); 0 (Retinol-Binding Proteins); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1159/000477860


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[PMID]:28837731
[Au] Autor:Li J; Ren J; Yip YWY; Zhang X; Chu KO; Ng TK; Chan SO; Pang CP; Chu WK
[Ad] Endereço:Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
[Ti] Título:Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental Mouse Model.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4193-4200, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To accurately evaluate the autoimmune inflammation, we aim to develop three quantitative measurements to monitor the inflammatory changes in the retina: retinal-choroidal thickness, major retinal vessel diameter, and electroretinography amplitudes. Methods: During a 21-day experimental period, eyes were examined by confocal scanning laser ophthalmoscopy, optical coherence tomography, fundus fluorescein angiography, and electroretinography in living mice, which were then subsequently killed for histologic assessments. Results: On day 21 postimmunization, inflammation was observed both in vivo and in vitro. Fold change of retinal-choroidal thickness and major retinal vessel diameter in experimental autoimmune uveoretinitis mice were significantly greater than controls (P < 0.001). Both scotopic and photopic electroretinography amplitudes were significantly attenuated when compared with control mice (P < 0.01). Our results showed that these three quantifiable indicators provided an objective and accurate evaluation of autoimmune inflammation, which are in good correlations with the reported clinical and histopathologic scoring systems (P < 0.05). Conclusions: These three indicators will be useful to detect the small but significant differences in the severity of experimental autoimmune uveoretinitis for future longitudinally therapeutic studies.
[Mh] Termos MeSH primário: Doenças Autoimunes/diagnóstico
Modelos Animais de Doenças
Retina/fisiopatologia
Vasos Retinianos/patologia
Retinite/diagnóstico
Uveíte/diagnóstico
[Mh] Termos MeSH secundário: Animais
Autoantígenos
Doenças Autoimunes/imunologia
Doenças Autoimunes/fisiopatologia
Permeabilidade Capilar
Dilatação Patológica
Eletrorretinografia
Proteínas do Olho
Feminino
Angiofluoresceinografia
Camundongos
Camundongos Endogâmicos C57BL
Oligopeptídeos
Oftalmoscopia
Retinite/imunologia
Retinite/fisiopatologia
Proteínas de Ligação ao Retinol
Uveíte/imunologia
Uveíte/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantigens); 0 (Eye Proteins); 0 (Oligopeptides); 0 (Retinol-Binding Proteins); 0 (interstitial retinol-binding protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22436


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[PMID]:28780307
[Au] Autor:Wang K; Zhu X; Zhang K; Zhou F; Zhu L
[Ad] Endereço:Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, Jiangsu Province, China. Electronic address: wangke@jsinm.org.
[Ti] Título:Neuroprotective effect of tetramethylpyrazine against all-trans-retinal toxicity in the differentiated Y-79 cells via upregulation of IRBP expression.
[So] Source:Exp Cell Res;359(1):120-128, 2017 Oct 01.
[Is] ISSN:1090-2422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is estimated that abnormal accumulation of all-trans-retinal (atRAL) is a leading cause of photoreceptor degeneration in retinal degenerative diseases. Deficiency of interphotoreceptor retinoid-binding protein (IRBP), a retinoid transporter in the visual cycle, is responsible for the impaired clearance of atRAL and results in atRAL toxicity in retina. Therefore, IRBP has been proposed to be a potent target in preventing atRAL-induced photoreceptor degeneration. In this study, the neuroprotective effect of tetramethylpyrazine (TMP) against atRAL toxicity in the differentiated Y-79 cells, a in vitro model of photoreceptor, was first investigated. Our findings showed that atRAL could induce cytotoxicity, oxidative/nitrosative stresses, apoptosis and leukostasis in the differentiated Y-79 cells; however, the pre-treatment of TMP significantly attenuated such effects in a dose-dependent manner. Furthermore, our results indicated that TMP exerted its neuroprotective effect mainly through upregulating IRBP expression. The present study significantly contributes to better understanding the important role of IRBP in retinal degenerative diseases and forms the basis of the therapeutic development of TMP in such diseases in the future.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Proteínas do Olho/metabolismo
Fármacos Neuroprotetores/farmacologia
Pirazinas/farmacologia
Retinaldeído/toxicidade
Proteínas de Ligação ao Retinol/metabolismo
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Morte Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Seres Humanos
Molécula 1 de Adesão Intercelular/metabolismo
Leucostasia/patologia
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Neurônios/patologia
Neuroproteção/efeitos dos fármacos
Nitrosação
Estresse Oxidativo/efeitos dos fármacos
Molécula 1 de Adesão de Célula Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Eye Proteins); 0 (Neuroprotective Agents); 0 (Pyrazines); 0 (Retinol-Binding Proteins); 0 (Vascular Cell Adhesion Molecule-1); 0 (interstitial retinol-binding protein); 126547-89-5 (Intercellular Adhesion Molecule-1); RR725D715M (Retinaldehyde); V80F4IA5XG (tetramethylpyrazine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28615254
[Au] Autor:Namaste SM; Aaron GJ; Varadhan R; Peerson JM; Suchdev PS; BRINDA Working Group
[Ad] Endereço:Strengthening Partnerships, Results, and Innovations in Nutrition Globally, Arlington, VA; sorrelnamaste@gmail.com.
[Ti] Título:Methodologic approach for the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):333S-347S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project is a multiagency and multicountry collaboration that was formed to improve micronutrient assessment and to better characterize anemia. The aims of the project were to ) identify factors associated with inflammation, ) assess the relations between inflammation, malaria infection, and biomarkers of iron and vitamin A status and compare adjustment approaches, and ) assess risk factors for anemia in preschool children (PSC) and women of reproductive age (WRA). The BRINDA database inclusion criteria included surveys that ) were conducted after 2004, ) had target groups of PSC, WRA, or both, and ) used a similar laboratory methodology for the measurement of ≥1 biomarker of iron [ferritin or soluble transferrin receptor or vitamin A status (retinol-binding protein or retinol)] and ≥1 biomarker of inflammation (α-1-acid glycoprotein or C-reactive protein). Individual data sets were standardized and merged into a BRINDA database comprising 16 nationally and regionally representative surveys from 14 countries. Collectively, the database covered all 6 WHO geographic regions and contained ∼30,000 PSC and 27,000 WRA. Data were analyzed individually and combined with the use of a meta-analysis. The methods that were used to standardize the BRINDA database and the analytic approaches used to address the project's research questions are presented in this article. Three approaches to adjust micronutrient biomarker concentrations in the presence of inflammation and malaria infection are presented, along with an anemia conceptual framework that guided the BRINDA project's anemia analyses. The BRINDA project refines approaches to interpret iron and vitamin A biomarker values in settings of inflammation and malaria infection and suggests the use of a new regression approach as well as proposes an anemia framework to which real-world data can be applied. Findings can inform guidelines and strategies to prevent and control micronutrient deficiencies and anemia globally.
[Mh] Termos MeSH primário: Anemia
Biomarcadores
Inflamação
Micronutrientes/deficiência
Avaliação Nutricional
Estado Nutricional
[Mh] Termos MeSH secundário: Adulto
Anemia/diagnóstico
Anemia Ferropriva/diagnóstico
Biomarcadores/análise
Proteína C-Reativa/análise
Pré-Escolar
Bases de Dados Factuais/normas
Feminino
Ferritinas/análise
Seres Humanos
Inflamação/diagnóstico
Ferro/análise
Malária
Orosomucoide/análise
Proteínas de Ligação ao Retinol/análise
Vitamina A/análise
Deficiência de Vitamina A/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142273


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[PMID]:28615251
[Au] Autor:Larson LM; Namaste SM; Williams AM; Engle-Stone R; Addo OY; Suchdev PS; Wirth JP; Temple V; Serdula M; Northrop-Clewes CA
[Ad] Endereço:Nutrition and Health Sciences Program, Laney Graduate School, and leila.larson@emory.edu.
[Ti] Título:Adjusting retinol-binding protein concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):390S-401S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The accurate estimation of the prevalence of vitamin A deficiency (VAD) is important in planning and implementing interventions. Retinol-binding protein (RBP) is often used in population surveys to measure vitamin A status, but its interpretation is challenging in settings where inflammation is common because RBP concentrations decrease during the acute-phase response. We aimed to assess the relation between RBP concentrations and inflammation and malaria in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y) and to investigate adjustment algorithms to account for these effects. Cross-sectional data from 8 surveys for PSC ( = 8803) and 4 surveys for WRA ( = 4191) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and combined with the use of a meta-analysis. Several approaches were explored to adjust RBP concentrations in PSC in inflammation and malaria settings as follows: ) the exclusion of subjects with C-reactive protein (CRP) concentrations >5 mg/L or α-1-acid glycoprotein (AGP) concentrations >1 g/L, ) the application of arithmetic correction factors, and ) the use of a regression correction approach. The impact of adjustment on the estimated prevalence of VAD (defined as <0.7 µmol/L) was examined in PSC. The relation between estimated VAD and CRP and AGP deciles followed a linear pattern in PSC. In women, the correlations between RBP and CRP and AGP were too weak to justify adjustments for inflammation. Depending on the approach used to adjust for inflammation (CRP+AGP), the estimated prevalence of VAD decreased by a median of 11-18 percentage points in PSC compared with unadjusted values. There was no added effect of adjusting for malaria on the estimated VAD after adjusting for CRP and AGP. The use of regression correction (derived from internal data), which accounts for the severity of inflammation, to estimate the prevalence of VAD in PSC in regions with inflammation and malaria is supported by the analysis of the BRINDA data. These findings contribute to the evidence on adjusting for inflammation when estimating VAD with the use of RBP.
[Mh] Termos MeSH primário: Anemia/sangue
Biomarcadores/sangue
Inflamação/sangue
Estado Nutricional
Proteínas de Ligação ao Retinol/análise
[Mh] Termos MeSH secundário: Adolescente
Adulto
Proteína C-Reativa/análise
Pré-Escolar
Estudos Transversais
Reações Falso-Positivas
Feminino
Seres Humanos
Lactente
Malária/sangue
Meia-Idade
Orosomucoide/análise
Valores de Referência
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142166


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[PMID]:28615252
[Au] Autor:Stoltzfus RJ; Klemm R
[Ad] Endereço:Division of Nutritional Sciences, Cornell University, Ithaca, NY; and rjs62@cornell.edu.
[Ti] Título:Research, policy, and programmatic considerations from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):428S-434S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project sought to inform the interpretation of iron and vitamin A biomarkers (ferritin, serum transferrin receptor, and retinol binding protein) in settings of prevalent inflammation as well as the prevention of and control strategies to address anemia. Our purpose is to comment on the contributions of the BRINDA to advance global knowledge with regard to iron and vitamin A status assessment in women and preschool children and to analyze the findings in terms of their rigor and usefulness for global nutrition research and programs. BRINDA investigators found that the acute-phase response is so prevalent that it must be assessed in surveys of iron and vitamin A status for valid interpretation of micronutrient biomarkers. Furthermore, they found that C-reactive protein and α-1-acid glycoprotein provide important and different information about these responses and that common survey variables cannot replace the information they provide. Developing a method for adjusting micronutrient biomarkers for the independent influence of inflammation is challenging and complex, and BRINDA has brought greater clarity to this challenge through the use of large and diverse data sets. When comparing approaches, the regression methods appear to perform best when sample sizes are sufficient and adequate statistical capacity is available. Further correction for malaria does not appear to materially alter regression-adjusted prevalence estimates. We suggest that researchers present both adjusted and unadjusted values for the micronutrient biomarkers. BRINDA findings confirm that iron deficiency is a common and consistent risk factor for anemia globally and that anemia control must combine iron interventions with control of infection and inflammation. Anemia control strategies must be informed by local data. By applying the knowledge in these studies, researchers, program planners, and evaluators working in populations with prevalent inflammation can use and interpret biomarkers with more confidence, tempered with necessary caution.
[Mh] Termos MeSH primário: Anemia
Biomarcadores/análise
Pesquisa Biomédica
Política de Saúde
Inflamação
Estado Nutricional
[Mh] Termos MeSH secundário: Anemia Ferropriva
Proteína C-Reativa
Pré-Escolar
Feminino
Ferritinas/sangue
Seres Humanos
Lactente
Ferro/deficiência
Micronutrientes/deficiência
Orosomucoide/análise
Receptores da Transferrina/sangue
Proteínas de Ligação ao Retinol/análise
Fatores de Risco
Deficiência de Vitamina A
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Receptors, Transferrin); 0 (Retinol-Binding Proteins); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142372


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[PMID]:28578159
[Au] Autor:Hurwitz JL; Jones BG; Penkert RR; Gansebom S; Sun Y; Tang L; Bramley AM; Jain S; McCullers JA; Arnold SR
[Ad] Endereço:Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN; Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center (UTHSC), Memphis, TN.
[Ti] Título:Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection.
[So] Source:J Pediatr;187:323-327, 2017 Aug.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Retinol binding protein and vitamin D were measured in children aged <5 years hospitalized with lower respiratory tract infection and respiratory syncytial virus and/or human metapneumovirus detections. Low vitamin levels were observed in 50% of the children and were associated with significantly elevated risk of the need for intensive care unit admission and invasive mechanical ventilation.
[Mh] Termos MeSH primário: Infecções por Paramyxoviridae/sangue
Pneumonia Viral/sangue
Infecções por Vírus Respiratório Sincicial/sangue
Proteínas de Ligação ao Retinol/análise
Vitamina D/sangue
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Hospitalização/estatística & dados numéricos
Seres Humanos
Lactente
Unidades de Terapia Intensiva Pediátrica/estatística & dados numéricos
Masculino
Metapneumovirus/isolamento & purificação
Respiração Artificial/estatística & dados numéricos
Vírus Sincicial Respiratório Humano/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Retinol-Binding Proteins); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170909
[Lr] Data última revisão:
170909
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28404834
[Au] Autor:Girard AW; Grant F; Watkinson M; Okuku HS; Wanjala R; Cole D; Levin C; Low J
[Ad] Endereço:Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA; awebb3@emory.edu.
[Ti] Título:Promotion of Orange-Fleshed Sweet Potato Increased Vitamin A Intakes and Reduced the Odds of Low Retinol-Binding Protein among Postpartum Kenyan Women.
[So] Source:J Nutr;147(5):955-963, 2017 May.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orange-fleshed sweet potato (OFSP) improves vitamin A (VA) status of young children; research with pregnant and lactating women is limited. We examined the effectiveness of the Mama SASHA (Sweetpotato Action for Security and Health in Africa) program to improve nutrition knowledge, diets, and nutritional status of pregnant and lactating women (PLW) in Western Kenya. Eight health facilities were allocated to the Mama SASHA intervention or comparison arms. PLW in intervention facilities received enhanced nutrition counseling at health clinics, were linked with community-based maternal support groups, and received vouchers for OFSP vine cuttings. Control PLW received clinic-based nutrition counseling only. A total of 505 women in early and midpregnancy, attending their first antenatal care visit, and with no previous engagement in project activities were enrolled from the 8 facilities. Nutrition and health-seeking knowledge, food security, dietary patterns, and anthropometric measurements were collected at 4 time points at ≤9 mo postpartum. VA intakes were assessed with multipass 24-h recalls in a subsample of 206 mothers at 8-10 mo postpartum. VA status was assessed by using serum retinol-binding protein (RBP). Impacts were estimated with multilevel mixed models adjusted for clustering and differences at enrollment. At enrollment, 22.9% of women had RBP <1.17 µmol/L. By 9 mo postpartum, intervention women had significantly higher intakes of VA [adjusted difference = 297.0 retinol activity equivalent (RAE) units; 95% CI: 82, 513 RAE units; = 0.01; = 206], greater consumption of VA-rich fruit and vegetables in the previous 7 d (difference-in-difference estimate: 0.40 d; 95% CI: 0.23, 0.56 d; < 0.01), and a 45% reduction in the odds of RBP <1.17 µmol/L (OR: 0.55; 95% CI: 0.33, 0.92; = 0.01). Promotion of OFSP to PLW through health services is a feasible strategy to improve women's nutrition knowledge, VA intakes, and maternal RBP.
[Mh] Termos MeSH primário: Promoção da Saúde/normas
Ipomoea batatas/química
Serviços de Saúde Materna
Estado Nutricional
Proteínas de Ligação ao Retinol/metabolismo
Deficiência de Vitamina A/prevenção & controle
Vitamina A
[Mh] Termos MeSH secundário: Adulto
Comportamento Alimentar
Feminino
Instalações de Saúde
Promoção da Saúde/métodos
Seres Humanos
Lactente
Recém-Nascido
Quênia/epidemiologia
Lactação
Masculino
Tubérculos
Período Pós-Parto
Gravidez
Prevalência
Avaliação de Programas e Projetos de Saúde
Proteínas de Ligação ao Retinol/deficiência
Vitamina A/administração & dosagem
Vitamina A/sangue
Vitamina A/farmacologia
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/dietoterapia
Deficiência de Vitamina A/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Retinol-Binding Proteins); 11103-57-4 (Vitamin A)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.3945/jn.116.236406



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