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Spritzer, Poli Mara
Lampe, Elisabeth
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[PMID]:29465575
[Au] Autor:Scalioni LP; Santos BRD; Spritzer PM; Villela-Nogueira CA; Laura Lewis-Ximenez L; Pollo-Flores P; Bordalo Cathalá Esberard E; Brandão-Mello CE; Lampe E; Villar LM
[Ad] Endereço:Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro.
[Ti] Título:Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: Cross sectional study.
[So] Source:Medicine (Baltimore);97(8):e9881, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays. Analyzed single nucleotide polymorphisms (SNPs) were: VDR-rs7975232 (ApaI) C>A, rs731236 A>G (TaqI), rs1544410 C>T (BsmI), rs10735810 T>C (FokI) and carrier globulin/binding protein (GC)-rs4588 and rs7041 and the haplotype bAt [CCA]. Hepatic fibrosis was assessed using Fib-4 and Forns index.Eighty-two (54.40%) patients demonstrated deficiency of vitamin D and this was associated to AST (P = .019 [CI: 1.003-1.034]), total cholesterol (P = .038 [CI: 1.004-1.164]), fibrosis grade (P < .001 [CI: 0.000-0.844]), and FokI (P = .028) allele T presence. Association was found between VDR polymorphism and fibrosis (BsmI andTaqI), triglycerides (TaqI), and HDL (FokI). DBP polymorphism was associated to HCV genotype (GC rs7041), previous HCV treatment, and GGT (GC rs4588).In conclusion, low frequency of vitamin D deficiency was found, but VDR polymorphisms were frequently associated to fibrosis grade suggesting that they could be used as disease evaluation markers to understand the mechanisms underlying the virus-host interaction.
[Mh] Termos MeSH primário: Hepatite C Crônica/sangue
Hepatite C Crônica/genética
Polimorfismo de Nucleotídeo Único
Receptores de Calcitriol/genética
Proteína de Ligação a Vitamina D/genética
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Estudos Transversais
Feminino
Hepatite C Crônica/virologia
Seres Humanos
Masculino
Meia-Idade
Vitamina D/sangue
Vitamina D/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Receptors, Calcitriol); 0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009881


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[PMID]:29088291
[Au] Autor:Jang H; Choi Y; Yoo I; Han J; Hong JS; Kim YY; Ka H
[Ad] Endereço:Department of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
[Ti] Título:Vitamin D-metabolic enzymes and related molecules: Expression at the maternal-conceptus interface and the role of vitamin D in endometrial gene expression in pigs.
[So] Source:PLoS One;12(10):e0187221, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin D is a secosteroid hormone with many varied functions including regulation of blood calcium levels, cell proliferation, immunity, and reproduction in mammals. Vitamin D is activated by 25-hydroxylase (CYP2R1) and 1-alpha-hydroxylase (CYP27B1) and is degraded by 24-hydroxylase (CYP24A1). Vitamin D is transported by vitamin D-binding protein (group-specific component, GC) through the bloodstream and regulates cellular actions by binding to vitamin D receptor (VDR). In this study, we determined the expression and regulation of vitamin D-related molecules and the role of vitamin D at the maternal-conceptus interface in pigs. Vitamin D-metabolizing enzymes CYP2R1, CYP27B1, and CYP24A1, vitamin D binding protein GC, and vitamin D receptor VDR were expressed in the endometrium in a pregnancy stage-specific manner as well as in conceptus and chorioallantoic tissues during pregnancy. VDR protein was localized to endometrial and trophoblastic cells. Concentrations of calcitriol, the active form of vitamin D, in the endometrial tissues were higher during early pregnancy than in mid- to late pregnancy, while plasma concentrations of calcitriol were highest during late pregnancy. Furthermore, calcitriol affected the expression of several genes related to conceptus implantation, vitamin D metabolism, calcium ion regulation, PG metabolism, and calcium-binding proteins in endometrial tissue explants. These results show that CYP2R1, CYP27B1, CYP24A1, GC, and VDR were expressed at the maternal-conceptus interface, endometrial calcitriol levels were regulated during pregnancy, and calcitriol modulated the expression of endometrial genes, suggesting that calcitriol may play an important role in the establishment and maintenance of pregnancy by regulating endometrial function in pigs.
[Mh] Termos MeSH primário: Endométrio/metabolismo
Vitamina D/metabolismo
[Mh] Termos MeSH secundário: 25-Hidroxivitamina D3 1-alfa-Hidroxilase/metabolismo
Animais
Colestanotriol 26-Mono-Oxigenase/metabolismo
Membrana Corioalantoide/metabolismo
Endométrio/fisiologia
Feminino
Regulação da Expressão Gênica/fisiologia
Gravidez
Receptores de Calcitriol/metabolismo
Suínos
Vitamina D/fisiologia
Proteína de Ligação a Vitamina D/metabolismo
Vitamina D3 24-Hidroxilase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Calcitriol); 0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); EC 1.14.13.13 (25-Hydroxyvitamin D3 1-alpha-Hydroxylase); EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187221


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[PMID]:28906406
[Au] Autor:Al-Daghri NM; Yakout S; Bukhari I; Khattak MNK; Al-Saleh Y; Aljohani N; Al-Attas OS; Alokail M
[Ad] Endereço:aBiochemistry Department, College of Science, King Saud University bCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences cObesity, Endocrine and Metabolism Center, King Fahad Medical City, Faculty of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
[Ti] Título:Parathyroid hormone in relation to various vitamin D metabolites in adult females.
[So] Source:Medicine (Baltimore);96(37):e8071, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin D binding protein (DBP) and albumin are the important determinants of circulatory 25(OH)D in adults. Physiological function of vitamin D is particularly regulated by DBPs. Serum parathyroid hormone (PTH) is considered as the biological activity reader of circulating 25(OH)D. We therefore examined the relationships between serum total, free, and bioavailable 25(OH)D versus PTH in apparently healthy Saudi female adults.A total of 350 apparently healthy Saudi female adults ([Mean ±â€Šstandard deviation] age [years] 52.9 ±â€Š9.2; body mass index [kg/m] 32.9 ±â€Š5.4) were included in this observational study. Anthropometrics was measured as well as fasting glucose, lipid profile, calcium and phosphorous using routine methods. Serum 25(OH)D was measured using an electrochemiluminescence immunoassay. Serum DBP was determined by ELISA. Free and bioavailable 25(OH)D were calculated by comparing concentrations of total 25(OH)D, DBP, and albumin.Data revealed that circulating total 25(OH)D had weak but significant inverse association with DBP (R = -0.24; P < .01), and strong inverse associations with free 25(OH)D (R = -0.87; P < .001), albumin-bound 25(OH)D (R = -0.88; P < .001), and bioavailable 25(OH)D (R = -0.89; p < 0.001). None of the vitamin D metabolites, including 25(OH)D, correlated with serum PTH.Various metabolites of 25(OH)D are not correlated with serum PTH in Saudi adult females. Bioavailable, albumin-bound and free 25(OH)D cannot be surrogate measures for vitamin D status, at least in this population.
[Mh] Termos MeSH primário: Hormônio Paratireóideo/sangue
Proteína de Ligação a Vitamina D/sangue
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Antropometria
Estudos Transversais
Técnicas Eletroquímicas
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Imunoensaio
Meia-Idade
Albumina Sérica/metabolismo
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Parathyroid Hormone); 0 (Serum Albumin); 0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008071


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[PMID]:28888576
[Au] Autor:Rahman MM; Hosen MB; Faruk MO; Hasan MM; Kabir Y; Howlader MZH
[Ad] Endereço:Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.
[Ti] Título:Association of vitamin D and vitamin D binding protein (DBP) gene polymorphism with susceptibility of type 2 diabetes mellitus in Bangladesh.
[So] Source:Gene;636:42-47, 2017 Dec 15.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Polymorphism in vitamin D binding protein gene may have an impact on serum vitamin D transport and thus may have relation with type 2 diabetes mellitus. In our study, we investigated the association of serum vitamin D level and vitamin D-binding protein gene polymorphism with the onset of type 2 diabetes mellitus. MATERIALS AND METHODS: Blood samples were collected from 104 type 2 diabetic patients and 107 healthy volunteers. Serum vitamin D was measured by high-performance liquid chromatography. Genetic analysis of vitamin D-binging protein gene was carried out by polymerase chain reaction - restriction fragment length polymorphism method. RESULTS: We found significantly (p<0.001) lower level of vitamin D in type 2 diabetic patients compared to control subjects. A significantly negative correlation (r=-0.25, p<0.05) between vitamin D level and fasting blood glucose level was found among type 2 diabetic subjects. The Glu/Glu at codon 416 (rs7041) (p<0.05) and Lys/Lys at codon 420 (rs4588) (p<0.01) variants of vitamin D binding protein gene was significantly higher in type 2 diabetic subjects than controls. The patients with Glu/Glu and Lys/Lys genotypes respectively at codon 416 (odds ratio=2.87; 95% confidence interval=1.19 to 6.95) and 420 (odds ratio=8.9; 95% confidence interval=1.89 to 41.99) were at high risk of developing type 2 diabetes. CONCLUSIONS: Our present study strongly suggests that there might have an association of vitamin D, and vitamin D-binding protein gene (codon 416 & 420) polymorphisms with the occurrence of type 2 diabetes mellitus.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/genética
Predisposição Genética para Doença
Polimorfismo Genético
Proteína de Ligação a Vitamina D/genética
Vitamina D/sangue
[Mh] Termos MeSH secundário: Adulto
Bangladesh
Diabetes Mellitus Tipo 2/sangue
Feminino
Genótipo
Haplótipos
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


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[PMID]:28882871
[Au] Autor:Qi L; Ma W; Heianza Y; Zheng Y; Wang T; Sun D; Rimm EB; Hu FB; Giovannucci E; Albert CM; Rexrode KM; Manson JE
[Ad] Endereço:From the Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (L.Q., Y.H., T.W., D.S.); Department of Epidemiology (L.Q., W.M., E.B.R., F.B.H., E.G., J.E.M.) and Department of Nutrition (L.Q., Y.Z., E.B.R., F.B.H., E.G.), Harvard T.H. Chan Sch
[Ti] Título:Independent and Synergistic Associations of Biomarkers of Vitamin D Status With Risk of Coronary Heart Disease.
[So] Source:Arterioscler Thromb Vasc Biol;37(11):2204-2212, 2017 Nov.
[Is] ISSN:1524-4636
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To comprehensively evaluate the independent associations and potential interactions of vitamin D-related biomarkers including total and bioavailable 25-hydroxyvitamin D (25OHD), VDBP (vitamin D binding protein), and parathyroid hormone (PTH) with risk of coronary heart disease (CHD). APPROACH AND RESULTS: We prospectively identified incident cases of nonfatal myocardial infarction and fatal CHD among women in the Nurses' Health Study during 20 years of follow-up (1990-2010). Using risk-set sampling, 1 to 2 matched controls were selected for each case. The analysis of 25OHD and PTH included 382 cases and 575 controls; the analysis of VDBP included 396 cases and 398 controls. After multivariate adjustment, plasma levels of total 25OHD, bioavailable 25OHD, and PTH were not significantly associated with CHD risk. VDBP was associated with a lower CHD risk with an extreme-quartile odds ratio of 0.60 (95% confidence interval, 0.39-0.92; trend=0.02). When examining the biomarkers jointly, a significant, inverse association between 25OHD and CHD was observed among participants with higher PTH levels ( for interaction=0.02). The odds ratio (95% confidence interval) comparing the highest quartile of 25OHD to lowest was 0.43 (0.23-0.82; trend=0.003) when PTH levels were above population median (35.3 pg/mL), whereas among the rest of participants the corresponding odds ratio (95% confidence interval) was 1.28 (0.70-2.36; trend=0.43). CONCLUSIONS: Our data suggest that higher 25OHD levels were associated with a lower CHD risk when PTH levels were high, whereas no association was observed for participants with low PTH levels. VDBP but not bioavailable 25OHD was independently associated with lower CHD risk.
[Mh] Termos MeSH primário: Infarto do Miocárdio/epidemiologia
Hormônio Paratireóideo/sangue
Deficiência de Vitamina D/epidemiologia
Proteína de Ligação a Vitamina D/sangue
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Estudos de Casos e Controles
Feminino
Seres Humanos
Incidência
Modelos Lineares
Meia-Idade
Análise Multivariada
Infarto do Miocárdio/diagnóstico
Infarto do Miocárdio/mortalidade
Enfermeiras e Enfermeiros
Razão de Chances
Estudos Prospectivos
Fatores de Proteção
Medição de Risco
Fatores de Risco
Fatores de Tempo
Estados Unidos/epidemiologia
Vitamina D/sangue
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/diagnóstico
Deficiência de Vitamina D/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (PTH protein, human); 0 (Parathyroid Hormone); 0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1161/ATVBAHA.117.309548


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[PMID]:28807113
[Au] Autor:Navarrete-Dechent C; Del Puerto C; Molgó M; González S; Pérez-Mateluna G; Uribe P; Camargo CA; Borzutzky A
[Ad] Endereço:Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Melanoma and Skin Cancer Unit, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
[Ti] Título:Circulating vitamin D-binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma: A case-control study.
[So] Source:J Am Acad Dermatol;77(3):575-577, 2017 09.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Melanoma/sangue
Neoplasias Cutâneas/sangue
Proteína de Ligação a Vitamina D/sangue
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Melanoma/patologia
Meia-Idade
Invasividade Neoplásica
Estudos Prospectivos
Neoplasias Cutâneas/patologia
Vitamina D/sangue
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


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[PMID]:28779988
[Au] Autor:Daffara V; Verdoia M; Rolla R; Nardin M; Marino P; Bellomo G; Carriero A; De Luca G; Novara Atherosclerosis Study Group (NAS)
[Ad] Endereço:Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Università del Piemonte Orientale, Novara, Italy.
[Ti] Título:Impact of polymorphism rs7041 and rs4588 of Vitamin D Binding Protein on the extent of coronary artery disease.
[So] Source:Nutr Metab Cardiovasc Dis;27(9):775-783, 2017 Sep.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: 25-hydroxyvitamin D deficiency represents a widespread social problem but also an emerging risk factor for cardiovascular disease. Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. We investigated whether the single nucleotide polymorphisms, rs7041 and rs4588, of VDBP are associated to the prevalence and extent of coronary artery disease. METHODS AND RESULTS: A consecutive cohort of patients undergoing coronary angiography in a single centre were included. Significant CAD was defined as at least 1 stenosis >50%, severe CAD for as left main and/or three-vessel disease. VDBP genetic status was assessed by polymerase chain reaction and restriction fragment length polymorphism technique. We included 1080 patients, 57% carried the mutated G allele of rs7041, whereas 22% carried the A allele of rs4588. Higher levels of C- reactive protein were observed in the carriers of G allele of rs7041 (p = 0.02), whereas 25-hydroxyvitamin D levels were similar across groups. A higher prevalence of lesions in the left anterior descending artery and a longer lesion length were observed in "A" carriers for rs4588 (p = 0.04 and p = 0.03, respectively). On the contrary, a higher prevalence of bifurcation lesions and chronic occlusions was observed in G carriers (p = 0.002 and p = 0.01 respectively). Both polymorphisms of VDBP did not affect the prevalence of CAD (rs7041: 79.1% TT vs 80.3% TG vs 78.5% GG, p = 0.81; rs4588 = 80.3% CC vs 78.5% AC + AA, p = 0.49) and severe CAD, (rs7041: 31.1% TT % vs 31.3% TG vs 30.6% GG, p = 0.88; rs4588: 32.2% CC vs 29.3% AC + AA, p = 0.31). Results were confirmed at multivariate analysis, for both rs7041 and rs4588. However, when including the levels of 25-hydroxyvitamin D in the multivariate model, we observed that 25(OH)D status and not genetic variants of VDBP were significantly associated with CAD (25-hydroxyvitamin D OR [95% CI] = 0.99 [0.97-1.0], p = 0.05; rs7041 TG: OR [95% CI] = 1.26 [0.73-2.19], p = 0.41; rs7041 GG: OR [95% CI] = 1.25 [0.82-1.91], p = 0.30; rs4588 AC + AA: OR [95% CI] = 0.76 [0.51-1.13], p = 0.18). CONCLUSION: This study showed in a large cohort of patients undergoing coronary angiography, that the polymorphisms rs7041 and rs4588 of VDBP are not associated with the levels of 25-hydroxyvitamin D nor with the prevalence and extent of CAD. In fact, 25-hydroxyvitamin D levels but not VDBP genetic status independently predicted the occurrence of coronary lesions at angiography.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/genética
Estenose Coronária/genética
Polimorfismo de Nucleotídeo Único
Proteína de Ligação a Vitamina D/genética
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Distribuição de Qui-Quadrado
Angiografia Coronária
Doença da Artéria Coronariana/sangue
Doença da Artéria Coronariana/diagnóstico por imagem
Doença da Artéria Coronariana/epidemiologia
Estenose Coronária/sangue
Estenose Coronária/diagnóstico por imagem
Estenose Coronária/epidemiologia
Feminino
Frequência do Gene
Estudos de Associação Genética
Marcadores Genéticos
Predisposição Genética para Doença
Heterozigoto
Homozigoto
Seres Humanos
Itália/epidemiologia
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Mutação
Razão de Chances
Fenótipo
Prevalência
Fatores de Risco
Índice de Gravidade de Doença
Vitamina D/análogos & derivados
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Genetic Markers); 0 (Vitamin D-Binding Protein); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28732681
[Au] Autor:Jones KS; Redmond J; Fulford AJ; Jarjou L; Zhou B; Prentice A; Schoenmakers I
[Ad] Endereço:Medical Research Council Human Nutrition Research, Fulbourn Road, Cambridge CB1 9NL, United Kingdom. Electronic address: kerry.jones@mrc-ewl.cam.ac.uk.
[Ti] Título:Diurnal rhythms of vitamin D binding protein and total and free vitamin D metabolites.
[So] Source:J Steroid Biochem Mol Biol;172:130-135, 2017 Sep.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vitamin D binding protein (DBP) concentration is known to influence the availability and bioactivity of vitamin D metabolites but its diurnal rhythm (DR), its inter-relationships with the DRs of vitamin D metabolites and its influence on free vitamin D metabolite concentrations are not well described. The DRs of plasma total 25(OH)D, total 1,25(OH) D, DBP, albumin and calculated free 25(OH)D and free 1,25(OH) D were measured in men and women aged 60-75 years and resident in the UK (n 30), Gambia (n 31) and China (n 30) with differences in lifestyle, dietary intake and vitamin D status. Blood samples were collected every 4h for 24h and DRs statistically analysed with Fourier regression. Gambians had significantly higher plasma concentrations of vitamin D metabolites and lower albumin concentration compared to the British and Chinese. Significant DRs were observed for all analytes and calculated free vitamin D metabolites (P<0.01). The pattern of DRs was similar between countries. The magnitude of the DRs of free 1,25(OH) D was attenuated compared to that of total 1,25(OH) D whereas it was not different between total and free 25(OH)D. Relationships between the DRs were generally weak. There was no phase shift between 1,25(OH) D and DBP with the strongest cross correlation at 0h time lag (r=0.15, P=<0.001). In comparison, 25(OH)D correlated less well with DBP (1h time lag, r=0.07, P=0.12). These data demonstrate a relationship between the DRs of 1,25(OH) D and DBP, possibly to maintain free 1,25(OH) D concentrations. In contrast, the DRs of total and free 25(OH)D appeared to be less influenced by DBP, suggesting that DBP has comparatively less effect on 25(OH)D concentration and 25(OH)D availability. This work highlights the importance of standardisation in timing of sample collection particularly for the assessment of plasma protein concentrations.
[Mh] Termos MeSH primário: Calcifediol/sangue
Calcitriol/sangue
Ritmo Circadiano
Proteína de Ligação a Vitamina D/sangue
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Africano
Idoso
Grupo com Ancestrais do Continente Asiático
Estudos de Coortes
Grupo com Ancestrais do Continente Europeu
Feminino
Regulação da Expressão Gênica
Seres Humanos
Masculino
Meia-Idade
Estações do Ano
Albumina Sérica/genética
Albumina Sérica/metabolismo
Proteína de Ligação a Vitamina D/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Serum Albumin); 0 (Vitamin D-Binding Protein); FXC9231JVH (Calcitriol); P6YZ13C99Q (Calcifediol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28575224
[Au] Autor:Moon RJ; Harvey NC; Cooper C; D'Angelo S; Curtis EM; Crozier SR; Barton SJ; Robinson SM; Godfrey KM; Graham NJ; Holloway JW; Bishop NJ; Kennedy S; Papageorghiou AT; Schoenmakers I; Fraser R; Gandhi SV; Prentice A; Inskip HM; Javaid MK; Maternal Vitamin D Osteoporosis Study Trial Group
[Ad] Endereço:Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD, United Kingdom.
[Ti] Título:Response to Antenatal Cholecalciferol Supplementation Is Associated With Common Vitamin D-Related Genetic Variants.
[So] Source:J Clin Endocrinol Metab;102(8):2941-2949, 2017 Aug 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Single-nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentration, but these relationships have not been examined following antenatal cholecalciferol supplementation. Objective: To determine whether SNPs in DHCR7, CYP2R1, CYP24A1, and GC are associated with the response to gestational cholecalciferol supplementation. Design: Within-randomization group analysis of the Maternal Vitamin D Osteoporosis Study trial of antenatal cholecalciferol supplementation. Setting: Hospital antenatal clinics. Participants: In total, 682 women of white ethnicity (351 placebo, 331 cholecalciferol) were included. SNPs at rs12785878 (DHCR7), rs10741657 (CYP2R1), rs6013897 (CYP24A1), and rs2282679 (GC) were genotyped. Interventions: 1000 IU/d cholecalciferol from 14 weeks of gestation until delivery. Main Outcome Measure: 25(OH)D at randomization and 34 weeks of gestation were measured in a single batch (Liaison; Diasorin, Dartford, UK). Associations between 25(OH)D and the SNPs were assessed by linear regression using an additive model [ß represents the change in 25(OH)D per additional common allele]. Results: Only rs12785878 (DHCR7) was associated with baseline 25(OH)D [ß = 3.1 nmol/L; 95% confidence interval (CI), 1.0 to 5.2 nmol/L; P < 0.004]. In contrast, rs10741657 (CYP2R1) (ß = -5.2 nmol/L; 95% CI, -8.2 to -2.2 nmol/L; P = 0.001) and rs2282679 (GC) (ß = 4.2 nmol/L; 95% CI, 0.9 to 7.5 nmol/L; P = 0.01) were associated with achieved 25(OH)D status following supplementation, whereas rs12785878 and rs6013897 (CYP24A1) were not. Conclusions: Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity.
[Mh] Termos MeSH primário: Colecalciferol/uso terapêutico
Deficiência de Vitamina D/prevenção & controle
Vitaminas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Alelos
Colestanotriol 26-Mono-Oxigenase/genética
Família 2 do Citocromo P450/genética
Suplementos Nutricionais
Método Duplo-Cego
Feminino
Genótipo
Seres Humanos
Modelos Lineares
Análise Multivariada
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/genética
Polimorfismo de Nucleotídeo Único
Gravidez
Resultado do Tratamento
Vitamina D/análogos & derivados
Vitamina D/sangue
Proteína de Ligação a Vitamina D/genética
Vitamina D3 24-Hidroxilase/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Vitamin D-Binding Protein); 0 (Vitamins); 1406-16-2 (Vitamin D); 1C6V77QF41 (Cholecalciferol); 64719-49-9 (25-hydroxyvitamin D); EC 1.14.14.1 (Cytochrome P450 Family 2); EC 1.14.14.24 (CYP2R1 protein, human); EC 1.14.15.15 (Cholestanetriol 26-Monooxygenase); EC 1.14.15.16 (CYP24A1 protein, human); EC 1.14.15.16 (Vitamin D3 24-Hydroxylase); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.1.21 (7-dehydrocholesterol reductase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2017-00682


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[PMID]:28541149
[Au] Autor:Pihl TH; Jacobsen S; Olsen DT; Højrup P; Grosche A; Freeman DE; Andersen PH; Houen G
[Ti] Título:Characterization of equine vitamin D-binding protein, development of an assay, and assessment of plasma concentrations of the protein in healthy horses and horses with gastrointestinal disease.
[So] Source:Am J Vet Res;78(6):718-728, 2017 Jun.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To purify and characterize equine vitamin D-binding protein (VDBP) from equine serum and to evaluate plasma concentrations of VDBP in healthy horses and horses with gastrointestinal injury or disease. ANIMALS 13 healthy laboratory animals (8 mice and 5 rabbits), 61 healthy horses, 12 horses with experimentally induced intestinal ischemia and reperfusion (IR), and 59 horses with acute gastrointestinal diseases. PROCEDURES VDBP was purified from serum of 2 healthy horses, and recombinant equine VDBP was obtained through a commercial service. Equine VDBP was characterized by mass spectrometry. Monoclonal and polyclonal antibodies were raised against equine VDBP, and a rocket immunoelectrophoresis assay for equine VDBP was established. Plasma samples from 61 healthy horses were used to establish working VDBP reference values for study purposes. Plasma VDBP concentrations were assessed at predetermined time points in horses with IR and in horses with naturally occurring gastrointestinal diseases. RESULTS The working reference range for plasma VDBP concentration in healthy horses was 531 to 1,382 mg/L. Plasma VDBP concentrations were significantly decreased after 1 hour of ischemia in horses with IR, compared with values prior to induction of ischemia, and were significantly lower in horses with naturally occurring gastrointestinal diseases with a colic duration of < 12 hours than in healthy horses. CONCLUSIONS AND CLINICAL RELEVANCE Plasma VDBP concentrations were significantly decreased in horses with acute gastrointestinal injury or disease. Further studies and the development of a clinically relevant assay are needed to establish the reliability of VDBP as a diagnostic and prognostic marker in horses.
[Mh] Termos MeSH primário: Gastroenteropatias/veterinária
Doenças dos Cavalos/sangue
Proteína de Ligação a Vitamina D/sangue
[Mh] Termos MeSH secundário: Animais
Anticorpos
Cólica/veterinária
Feminino
Gastroenteropatias/sangue
Cavalos
Intestinos/irrigação sanguínea
Isquemia/sangue
Isquemia/veterinária
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Coelhos
Valores de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Vitamin D-Binding Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.6.718



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