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[PMID]: 29262450 [Au] Autor: Lin PL; Liang FY; Han P; Chen RH; Yu ST; Cai Q; Huang XM [Ad] Endereço: Department of Otorhinolaryngology Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510289, China. [Ti] Título: [Gasless endoscopic selective lateral neck dissection via an anterior chest approach for papillary thyroid carcinomas]. [So] Source: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(12):915-920, 2017 Dec 07. [Is] ISSN: 1673-0860 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: To assess the safety and curative effect of gasless endoscopic selective lateral neck dissection (GESLND) via an anterior chest approach for papillary thyroid carcinoma (PTC). Eighteen patients with PTC(T1-2N1bM0, size<3.0 cm), having GESLND via an anterior chest approach, were included from November 2008 to December 2016. GESLND via an anterior chest approach was successfully performed in all 18 PTC patients (seven male and eleven female) with 83.3% of T1 and 16.7% of T2. The mean operative time of selective lateral neck dissection was 73 min (range 51-92 min). The mean of intraoperative bleeding was 61.1 ml (range 30-120 ml). No major complications occurred except one transient hypoparathyroidism. No residual thyroid glands were detected on ultrasonography and thyroglobulin was(0.73±0.16)ng/ml three months postoperatively. The median of follow-up was 54.5 months (range 6-104 months). No recurrence disease was observed in any patient on ultrasonography, computer tomography, thyroglobulin or selective iodine-131 scan during the follow-up period. The cosmetic result and functional preservation was excellent, when the assessments were performed three months postoperatively. GESLND via an anterior chest approach is feasible and safe for selected PTCs, with superior appearance. [Mh] Termos MeSH primário: Carcinoma Papilar/cirurgia Endoscopia/métodos Esvaziamento Cervical/métodos Neoplasias da Glândula Tireoide/cirurgia [Mh] Termos MeSH secundário: Perda Sanguínea Cirúrgica/estatística & dados numéricos Carcinoma Papilar/patologia Endoscopia/efeitos adversos Feminino Seres Humanos Hipoparatireoidismo/etiologia Radioisótopos do Iodo Masculino Duração da Cirurgia Parede Torácica/cirurgia Tireoglobulina/sangue Neoplasias da Glândula Tireoide/patologia Tomografia Computadorizada por Raios X Ultrassonografia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Iodine Radioisotopes); 0 (Iodine-131); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.1673-0860.2017.12.008

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[PMID]: 28454525 [Au] Autor: Zhao H; Wang Y; Wang MJ; Zhang ZH; Wang HR; Zhang B; Guo HQ [Ad] Endereço: Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Nanli Panjiayuan Lane, Chaoyang District, Beijing, 100021, People's Republic of China. [Ti] Título: Influence of presence/absence of thyroid gland on the cutoff value for thyroglobulin in lymph-node aspiration to detect metastatic papillary thyroid carcinoma. [So] Source: BMC Cancer;17(1):296, 2017 04 28. [Is] ISSN: 1471-2407 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Thyroglobulin measurement with fine-needle aspiration (Tg-FNA) is a sensitive method for detecting metastatic papillary thyroid carcinoma (PTC). However, the diagnostic threshold is not well established and the influence of the thyroid gland on the cutoff value is also controversial. In this study, patients were classified into two groups according to the presence or absence of thyroid tissue, to determine an appropriate cutoff value for clinical practice. METHODS: Patients with a history of thyroid nodules or surgery for PTC and with enlarged cervical lymph nodes on an FNA examination were enrolled for Tg-FNA detection. RESULTS: One hundred ninety-six lymph nodes (189 patients) were included: 100 from preoperative patients, 49 from patients treated with partial thyroid ablation, and 47 from patients with total thyroid ablation. In 149 lymph nodes from patient with thyroids, the cutoff value for Tg-FNA was 55.99 ng/mL (sensitivity, 95.1%; specificity, 100%), whereas in 47 lymph nodes from patients without a thyroid, it was 9.71 ng/mL (sensitivity, 96.7%; specificity, 100%). Thus, the cutoff value for Tg-FNA was higher in patients with thyroids than in patients without thyroids. CONCLUSIONS: The cutoff value for Tg-FNA is influenced by residual thyroid tissue, and a higher cutoff value is recommended for patients with thyroids than for patients without thyroids. [Mh] Termos MeSH primário: Carcinoma Papilar/metabolismo Tireoglobulina/metabolismo Glândula Tireoide/metabolismo Neoplasias da Glândula Tireoide/metabolismo [Mh] Termos MeSH secundário: Biomarcadores Tumorais/metabolismo Biópsia por Agulha Fina/métodos Carcinoma Papilar/patologia Carcinoma Papilar/cirurgia Seres Humanos Linfonodos/patologia Metástase Linfática Tireoglobulina/sangue Glândula Tireoide/patologia Glândula Tireoide/cirurgia Neoplasias da Glândula Tireoide/patologia Neoplasias da Glândula Tireoide/cirurgia Tireoidectomia/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Biomarkers, Tumor); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180202 [Lr] Data última revisão: 180202 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170430 [St] Status: MEDLINE [do] DOI: 10.1186/s12885-017-3296-3

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[PMID]: 28743746 [Au] Autor: Citterio CE; Veluswamy B; Morgan SJ; Galton VA; Banga JP; Atkins S; Morishita Y; Neumann S; Latif R; Gershengorn MC; Smith TJ; Arvan P [Ad] Endereço: From the Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105. [Ti] Título: triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone. [So] Source: J Biol Chem;292(37):15434-15444, 2017 09 15. [Is] ISSN: 1083-351X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The thyroid gland secretes primarily tetraiodothyronine (T ), and some triiodothyronine (T ). Under normal physiological circumstances, only one-fifth of circulating T is directly released by the thyroid, but in states of hyperactivation of thyroid-stimulating hormone receptors (TSHRs), patients develop a syndrome of relative T toxicosis. Thyroidal T production results from iodination of thyroglobulin (TG) at residues Tyr and Tyr , whereas thyroidal T production may originate in several different ways. In this study, the data demonstrate that within the carboxyl-terminal portion of mouse TG, T is formed independently of deiodination from T We found that upon iodination , T formation in TG was decreased in mice lacking TSHRs. Conversely, T that can be formed upon iodination of TG secreted from PCCL3 (rat thyrocyte) cells was augmented from cells previously exposed to increased TSH, a TSHR agonist, a cAMP analog, or a TSHR-stimulating antibody. We present data suggesting that TSH-stimulated TG phosphorylation contributes to enhanced T formation. These effects were reversed within a few days after removal of the hyperstimulating conditions. Indeed, direct exposure of PCCL3 cells to human serum from two patients with Graves' disease, but not control sera, led to secretion of TG with an increased intrinsic ability to form T upon iodination. Furthermore, TG secreted from human thyrocyte cultures hyperstimulated with TSH also showed an increased intrinsic ability to form T Our data support the hypothesis that TG processing in the secretory pathway of TSHR-hyperstimulated thyrocytes alters the structure of the iodination substrate in a way that enhances T formation, contributing to the relative T toxicosis of Graves' disease. [Mh] Termos MeSH primário: Processamento de Proteína Pós-Traducional Receptores da Tireotropina/agonistas Transdução de Sinais Tireoglobulina/metabolismo Células Epiteliais da Tireóide/metabolismo Tireotropina/metabolismo Tri-Iodotironina/biossíntese [Mh] Termos MeSH secundário: Animais Proteínas de Ligação ao Cálcio/agonistas Proteínas de Ligação ao Cálcio/genética Proteínas de Ligação ao Cálcio/metabolismo Caseína Quinase I/genética Caseína Quinase I/metabolismo Linhagem Celular Células Cultivadas Proteínas da Matriz Extracelular/agonistas Proteínas da Matriz Extracelular/genética Proteínas da Matriz Extracelular/metabolismo Doença de Graves/sangue Doença de Graves/metabolismo Doença de Graves/patologia Halogenação Seres Humanos Camundongos Endogâmicos C57BL Camundongos Knockout Fosforilação Proteínas Serina-Treonina Quinases/química Proteínas Serina-Treonina Quinases/genética Proteínas Serina-Treonina Quinases/metabolismo Ratos Receptores da Tireotropina/genética Receptores da Tireotropina/metabolismo Tireoglobulina/secreção Células Epiteliais da Tireóide/citologia Células Epiteliais da Tireóide/patologia Células Epiteliais da Tireóide/secreção Tirosina/metabolismo Regulação para Cima [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 0 (Calcium-Binding Proteins); 0 (Extracellular Matrix Proteins); 0 (FAM20C protein, mouse); 0 (Receptors, Thyrotropin); 06LU7C9H1V (Triiodothyronine); 42HK56048U (Tyrosine); 9002-71-5 (Thyrotropin); 9010-34-8 (Thyroglobulin); EC 2.7.11.1 (Casein Kinase I); EC 2.7.11.1 (FAM20C protein, human); EC 2.7.11.1 (Fam20C protein, rat); EC 2.7.11.1 (Protein-Serine-Threonine Kinases) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171230 [Lr] Data última revisão: 171230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170727 [St] Status: MEDLINE [do] DOI: 10.1074/jbc.M117.784447

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[PMID]: 27775867 [Au] Autor: Fischer J; Eberlein B; Hilger C; Eyer F; Eyerich S; Ollert M; Biedermann T [Ad] Endereço: Department of Dermatology, Faculty of Medicine, Eberhard Karls University Tuebingen, Tuebingen, Germany. [Ti] Título: Alpha-gal is a possible target of IgE-mediated reactivity to antivenom. [So] Source: Allergy;72(5):764-771, 2017 May. [Is] ISSN: 1398-9995 [Cp] País de publicação: Denmark [La] Idioma: eng [Ab] Resumo: BACKGROUND: Antivenoms are mammalian immunoglobulins with the ability to neutralize snake venom components and to mitigate the progression of toxic effects. Immediate hypersensitivity to antivenoms often occurs during the first administration of these heterologous antibodies. A comparable clinical situation occurred after introduction of cetuximab, a chimeric mouse-human antibody, for cancer treatment. The carbohydrate epitope galactose-alpha-1,3-galactose, located on the Fab region of cetuximab, was identified as the target responsible for IgE reactivity. OBJECTIVE: To investigate whether serum IgE antibodies directed to the α-gal epitope are associated with hypersensitivity to equine antivenoms. METHODS: Antivenoms were screened for α-gal epitopes via immunoblot and in comparison with cetuximab and pork kidney by IgE reactivity assays. Basophil activation tests were used to investigate reactivity to antivenoms in samples from 20 patients with specific IgE antibodies to α-gal and 10 controls. Additional IgE detection, IgE inhibition, ImmunoCAP inhibition, and skin prick tests were performed using samples from selected patients. RESULTS: Both antivenoms and cetuximab induced positive skin prick test results in patients with sIgE to α-gal. Alpha-gal epitopes were detected by immunoblotting on antivenoms. Measurements of IgE reactivity and ImmunoCAP inhibition indicated that the antivenoms contained lower α-gal contents than cetuximab. Deglycosylation assays and IgE inhibition tests confirmed that IgE-mediated reactivity to antivenom is associated with α-gal. Antivenoms, pork kidney, and cetuximab activated basophils from patients with IgE to α-gal. CONCLUSION: Alpha-gal is a potential target of IgE-mediated reactivity to equine antivenom and a possible cause of the high incidence of hypersensitivity reactions during the first application of equine antivenom. [Mh] Termos MeSH primário: Antivenenos/imunologia Hipersensibilidade Imediata/imunologia Imunoglobulina E/imunologia alfa-Galactosidase/imunologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Animais Basófilos/imunologia Basófilos/metabolismo Biomarcadores Cetuximab/efeitos adversos Relação Dose-Resposta Imunológica Epitopos/imunologia Feminino Cavalos Seres Humanos Hipersensibilidade Imediata/diagnóstico Hipersensibilidade Imediata/metabolismo Masculino Meia-Idade Testes Cutâneos Tetraspanina 30/metabolismo Tireoglobulina/imunologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antivenins); 0 (Biomarkers); 0 (Epitopes); 0 (Tetraspanin 30); 37341-29-0 (Immunoglobulin E); 9010-34-8 (Thyroglobulin); EC 3.2.1.22 (alpha-Galactosidase); PQX0D8J21J (Cetuximab) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171207 [Lr] Data última revisão: 171207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE [do] DOI: 10.1111/all.13073

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[PMID]: 28467308 [Au] Autor: Trimboli P; Zilioli V; Imperiali M; Giovanella L [Ad] Endereço: . [Ti] Título: Thyroglobulin autoantibodies before radioiodine ablation predict differentiated thyroid cancer outcome. [So] Source: Clin Chem Lab Med;55(12):1995-2001, 2017 Oct 26. [Is] ISSN: 1437-4331 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: BACKGROUND: Serum thyroglobulin (Tg) is essential to manage differentiated thyroid carcinoma (DTC). However, Tg determination is affected by circulating Tg antibodies (TgAb), and a role of TgAb as surrogate biomarker has been proposed. Here we evaluated the role of TgAb measured before and after radioiodine ablation (RRA) as potential predictors of prognosis. METHODS: Patients treated since 2006 were screened. Cancers with structural relapse were defined as recurrent. Both Tg and TgAb were measured by immunoassays on the fully automated Kryptor® platform (BRAHMS Gmbh, Henningsdorf, Germany). RESULTS: A series of 215 DTC patients was enrolled, of whom 28.8% had positive preablation TgAb. Overall, 2.8% patients died by DTC and 11% recurred. High-risk class (p=0.004) and cancer relapse (p=0.007) occurred more frequently in positive TgAb, whereas better disease-free survival was observed in negative group (hazard ratio 2.59, p=0.01). Having positive preablation TgAb was significantly associated with risk to develop recurrence (odds ratio 3.57, p=0.004). Among positive TgAb subgroup, higher levels were recorded in recurrent cases (p=0.0001), and the most accurate preablation TgAb threshold was 107.5 IU/mL. When TgAb were measured at first follow-up, recurrence rate was significantly (p<0.0001) higher in persistently TgAb-positive patients (75%) than normalized ones (2.4%). At that time, the highest negative predictive value could be obtained when considering TgAb normalization (<33 IU/mL) or reduction by ≥36.4%. CONCLUSIONS: Positive TgAb before RRA indicates higher risk of poor prognosis, but their significant drop 6-12 months later could be considered a favorable factor. [Mh] Termos MeSH primário: Autoanticorpos/sangue Autoanticorpos/imunologia Imunoensaio Radioisótopos do Iodo/uso terapêutico Tireoglobulina/imunologia Neoplasias da Glândula Tireoide/imunologia Neoplasias da Glândula Tireoide/radioterapia [Mh] Termos MeSH secundário: Automação Seres Humanos Prognóstico Neoplasias da Glândula Tireoide/sangue Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Autoantibodies); 0 (Iodine Radioisotopes); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171129 [Lr] Data última revisão: 171129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE

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[PMID]: 29142052 [Au] Autor: Giovanella L; Imperiali M; Verburg FA; Trimboli P [Ad] Endereço: Department of Nuclear Medicine and Thyroid CentreOncology Institute of Southern Switzerland, Bellinzona, Switzerland luca.giovanella@eoc.ch. [Ti] Título: Early post-treatment risk stratification of differentiated thyroid cancer: comparison of three high-sensitive Tg assays. [So] Source: Eur J Endocrinol;178(1):77-84, 2018 Jan. [Is] ISSN: 1479-683X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To assess the diagnostic performance of three high-sensitive assays in a cohort of TgAb-negative and TgAb-positive differentiated thyroid cancer (DTC) patients. DESIGN: Retrospective study on prospectively selected DTC patients. METHODS: Serum samples from 154 DTC patients were obtained 6-12 months after radioiodine ablation and tested by Beckman, Roche, BRAHMS Tg and TgAb assays, respectively. Receiver operating characteristics curves for Tg were plotted using outcome over time as benchmark and assay-specific Tg thresholds were obtained for TgAb-negative and TgAb-positive patients. RESULTS: The frequency of positive TgAb was 21, 20 and 20% for Beckman, Roche and BRAHMS, respectively. In TgAb-negative patients, clinical sensitivities and specificities of 100% and 85-95%, respectively, were observed across all assays. In TgAb-positive patients, clinical sensitivities and specificities of 80-100% and 92-96%, respectively, were observed using lower thresholds than in patients without TgAb. CONCLUSIONS: Adopting appropriate thresholds, lower than those for TgAb-negative patients, is possible to reliably follow TgAb-positive patients using highly sensitive Tg assays. [Mh] Termos MeSH primário: Autoanticorpos/sangue Tireoglobulina/sangue Neoplasias da Glândula Tireoide/sangue Neoplasias da Glândula Tireoide/terapia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Feminino Seguimentos Seres Humanos Masculino Meia-Idade Estudos Prospectivos Radioimunoensaio/normas Estudos Retrospectivos Medição de Risco Neoplasias da Glândula Tireoide/diagnóstico Fatores de Tempo Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Autoantibodies); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171128 [Lr] Data última revisão: 171128 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171117 [St] Status: MEDLINE [do] DOI: 10.1530/EJE-17-0663

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[PMID]: 29049252 [Au] Autor: Salvatore B; Klain M; Nicolai E; D'Amico D; De Matteis G; Raddi M; Fonti R; Pellegrino T; Storto G; Cuocolo A; Pace L [Ad] Endereço: aIstituto di Biostrutture e Bioimmagini, CNR bDipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli FedericoII cIRCCS - SDN, Napoli dMedicina Nucleare, IRCCS - CROB, Rionero in Vulture eDipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana," Università degli Studi di Salerno, Salerno, Italy. [Ti] Título: Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy. [So] Source: Medicine (Baltimore);96(42):e8344, 2017 Oct. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). METHODS: Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9 ±â€Š5 years after empiric RAI therapy were retrospectively analyzed. RESULTS: FDG-PET/CT was negative in 15 (30.6%) patients and positive in 34 (69.4%), whereas postradioiodine therapy whole body scan (t-WBS) was negative in 16 (32.7%) and positive in 33 (67.3%) patients. FDG-PET/CT and t-WBS were in agreement in 32 patients (7 both negative and 25 both positive); on the contrary, in 17 patients there was disagreement between FDG-PET/CT and t-WBS (P =ns). At short-term follow-up, Tg normalized in 19 (38.8%) patients and was unchanged or increased in 30 (61.2%). Of the 15 patients with negative FDG-PET/CT, 11 (73.3%) showed Tg normalization, whereas of the 34 patients with positive FDG-PET/CT, only 8 (23.5%) had Tg normalization (χ =8.9, P < .005). At multivariate analysis, FDG-PET/CT and Tg normalization at short-term follow-up were independent predictors of disease-free survival (χ =26.3, P < .0001), while Tg normalization was the only variable associated with overall survival χ =7.2, P < .01). CONCLUSION: FDG-PET/CT in association with Tg normalization at short-term follow-up may be useful for long-term prognostic stratification in DTC patients. [Mh] Termos MeSH primário: Radioisótopos do Iodo/uso terapêutico Compostos Radiofarmacêuticos/uso terapêutico Neoplasias da Glândula Tireoide/diagnóstico por imagem Neoplasias da Glândula Tireoide/tratamento farmacológico [Mh] Termos MeSH secundário: Adulto Idoso Intervalo Livre de Doença Feminino Fluordesoxiglucose F18 Seres Humanos Masculino Meia-Idade Tomografia Computadorizada com Tomografia por Emissão de Pósitrons Prognóstico Estudos Retrospectivos Tireoglobulina/biossíntese Neoplasias da Glândula Tireoide/mortalidade Neoplasias da Glândula Tireoide/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Iodine Radioisotopes); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171122 [Lr] Data última revisão: 171122 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171020 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008344

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[PMID]: 28931076 [Au] Autor: Barington M; Brorson MM; Hofman-Bang J; Rasmussen ÅK; Holst B; Feldt-Rasmussen U [Ad] Endereço: Department of Medical Endocrinology, Rigshospitalet, University Hospital Copenhagen, Copenhagen, Denmark. [Ti] Título: Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo. [So] Source: PLoS One;12(9):e0184992, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production. [Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos Grelina/farmacologia Glândula Tireoide/citologia Tireotropina/farmacologia [Mh] Termos MeSH secundário: Células Cultivadas Seres Humanos Receptores de Grelina/metabolismo Receptores da Tireotropina/metabolismo Tireoglobulina/metabolismo Glândula Tireoide/efeitos dos fármacos Glândula Tireoide/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Ghrelin); 0 (Receptors, Ghrelin); 0 (Receptors, Thyrotropin); 9002-71-5 (Thyrotropin); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170921 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0184992

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[PMID]: 28911140 [Au] Autor: Yehuda M; Wang CH; Pak Y; Chiu KC; Gianoukakis AG [Ad] Endereço: Division of Endocrinology and Metabolism, Harbor-University of California Los Angeles Medical Center, Torrance, California 90502. [Ti] Título: Parity and Risk of Thyroid Autoimmunity Based on the NHANES (2001-2002, 2007-2008, 2009-2010, and 2011-2012). [So] Source: J Clin Endocrinol Metab;102(9):3437-3442, 2017 Sep 01. [Is] ISSN: 1945-7197 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Context: Autoimmune thyroid disease is more common in women than in men. Fetal microchimerism has been implicated as a potential explanation for this disparity. Objective: The objective of this study was to evaluate the relationship between parity and thyroid autoimmunity in the US population. Design, Setting, Patients: The National Health and Nutrition Examination Survey was used to identify females with antithyroperoxidase (TPOAb) and antithyroglobulin antibody (TgAb) measurements and parity data. Subjects (n = 4864) were categorized as never pregnant (n = 909) or previously pregnant (n = 3955). The association of parity with thyroid autoantibodies was examined both qualitatively and quantitatively. Thyroid autoimmunity was defined as TPOAb and/or TgAb titers above the reference limits. Results: Previous pregnancy carried an odds ratio (OR) of 1.55 [95% confidence interval (CI): 1.26 to 1.91] for thyroid autoimmunity compared with never pregnant. Number of pregnancies was associated with thyroid autoimmunity: OR = 1.37 (95% CI: 1.02 to 1.84); 1.4 (95% CI: 1.08 to 1.81); 1.52 (95% CI: 1.18 to 1.96); and 1.73 (95% CI: 1.38 to 2.18) for 1, 2, 3, and ≥4 pregnancies, respectively. Because ever-pregnant women differed in several variables-age, race, smoking status, history of thyroid disease, and urinary iodine level-from never-pregnant women (P < 0.001), a multivariate regression analysis was performed, which showed no association of pregnancy with thyroid autoimmunity. The association was further examined utilizing an age-matched analysis, which confirmed the absence of an association between thyroid autoimmunity and parity. Conclusion: Although we initially observed a strong association between parity and thyroid autoimmunity, after controlling for age and other variables, we were unable to identify an association. [Mh] Termos MeSH primário: Autoanticorpos/imunologia Paridade/imunologia Tireoglobulina/imunologia Tireoidite Autoimune/epidemiologia Tireoidite Autoimune/imunologia [Mh] Termos MeSH secundário: Adulto Estudos de Coortes Intervalos de Confiança Bases de Dados Factuais Feminino Seres Humanos Incidência Análise Multivariada Inquéritos Nutricionais Razão de Chances Gravidez Resultado da Gravidez Valores de Referência Estudos Retrospectivos Medição de Risco Tireoglobulina/sangue Doenças da Glândula Tireoide/epidemiologia Doenças da Glândula Tireoide/imunologia Tireoidite Autoimune/fisiopatologia Estados Unidos [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Autoantibodies); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171012 [Lr] Data última revisão: 171012 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170916 [St] Status: MEDLINE [do] DOI: 10.1210/jc.2017-00290

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[PMID]: 28817605 [Au] Autor: Mei D; Lv B; Chen B; Xiao S; Jiang J; Xie Y; Jiang L [Ad] Endereço: Department of Clinical Medicine, School of Medicine, Shandong University, Jinan, China. [Ti] Título: All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis. [So] Source: PLoS One;12(8):e0182835, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Recently, diagnoses of radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) have become more common; prognosis is poor. It has been suggested that cancer stem cells account for radiotherapy resistance. By flow cytometry, different expression percents of CD133 and OCT4 in thyroid cancer cell lines were detected. By real-time quantitative PCR, different mRNA expression of CD133, OCT4, GLUT1, thyroglobulin (TG), thyroperoxidase (TPO) and sodium iodine symporter (NIS) was analyzed; the localization of CD133, OCT4, and NIS expression was examined using immunofluorescence confocal microscopy. Different expression of CD133, OCT4, and NIS in 21 human thyroid cancer and nodule tissues was investigated using immunohistochemistry. CD133-positive cells were isolated by magnetic sorting. Stronger colony formation ability of CD133-positive and weaker ability of CD133-negative cells in vivo were examined by colony formation. The effects of all-trans retinoic acid (ATRA) on CD133-positive cells in vivo were explored with Cell Counting Kit-8, colony formation, apoptosis, cell cycle, and ethynyl deoxyuridine assays. The ARO cell line and RAI-R DTC tissue specimens had more CD133-positive cells. NIS expression was significantly lower in RAI-R DTC tissue compared to radioiodine-sensitive DTC (RAI-DTC) tissue and specimens from patients with thyroid nodule. ATRA inhibited the stem cell characteristics of CD133-positive cells and induced CD133-positive cell differentiation to CD133-negative cells, and promoted CD133-positive cell apoptosis. [Mh] Termos MeSH primário: Antígeno AC133/genética Antineoplásicos/farmacologia Apoptose Células-Tronco Neoplásicas/efeitos dos fármacos Neoplasias da Glândula Tireoide/patologia Tretinoína/farmacologia [Mh] Termos MeSH secundário: Antígeno AC133/metabolismo Linhagem Celular Tumoral Transportador de Glucose Tipo 1/genética Transportador de Glucose Tipo 1/metabolismo Seres Humanos Células-Tronco Neoplásicas/metabolismo Células-Tronco Neoplásicas/patologia Fator 3 de Transcrição de Octâmero/genética Fator 3 de Transcrição de Octâmero/metabolismo Tireoglobulina/genética Tireoglobulina/metabolismo Neoplasias da Glândula Tireoide/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (AC133 Antigen); 0 (Antineoplastic Agents); 0 (Glucose Transporter Type 1); 0 (Octamer Transcription Factor-3); 0 (POU5F1 protein, human); 5688UTC01R (Tretinoin); 9010-34-8 (Thyroglobulin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170818 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0182835

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